locus-tag class description CGK93_00010 ENOG41084CH 50S ribosomal protein l34 CGK93_00015 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CGK93_00020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CGK93_00025 ENOG4108J5G 6-phosphogluconate dehydrogenase CGK93_00030 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CGK93_00035 ENOG4105K7N UPF0232 protein CGK93_00040 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CGK93_00050 ENOG4108ZED Transmembrane domain of unknown function (DUF3566) CGK93_00075 ENOG4107R8N Glycosyl transferase, family 2 CGK93_00100 ENOG4108R3E Dna-3-methyladenine glycosylase i CGK93_00110 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CGK93_00115 ENOG4105WH9 RNA polymerase CGK93_00125 ENOG4105XBB septation inhibitor protein CGK93_00130 ENOG4108U4N (sortase) family CGK93_00145 ENOG4107TPY serine threonine protein kinase CGK93_00150 ENOG4105CJN penicillin-binding protein CGK93_00165 ENOG4105HZM Fha domain containing protein CGK93_00170 ENOG4105TV9 FHA Domain-Containing protein CGK93_00180 ENOG4105FDP GntR family transcriptional regulator CGK93_00185 ENOG4105DIA mandelate racemase muconate lactonizing CGK93_00190 ENOG4108S01 response regulator CGK93_00195 ENOG4105BZU Histidine kinase CGK93_00265 ENOG4105BZ1 (ABC) transporter CGK93_00275 ENOG4105ETE Transcriptional regulator (LacI family CGK93_00290 ENOG4105E0A ABC, transporter CGK93_00295 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) CGK93_00305 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase CGK93_00320 ENOG41073TP transcriptional regulator CGK93_00325 ENOG4105E7W lamb ycsf family protein CGK93_00335 ENOG4105P4J Allophanate hydrolase, subunit 1 CGK93_00340 ENOG4108JIK carboxylase CGK93_00345 ENOG4105QE3 oxidoreductase CGK93_00350 ENOG4105ETE Transcriptional regulator (LacI family CGK93_00355 ENOG4105C09 Bile acid CGK93_00360 ENOG4105CHH sulfate transporter CGK93_00380 ENOG4105CHF Glutathione S-transferase CGK93_00385 ENOG410667J hydrolase CGK93_00425 ENOG4105BZW Glycerate kinase CGK93_00455 ENOG4105NAE bifunctional deaminase-reductase domain protein CGK93_00510 ENOG41062BK proline dehydrogenase CGK93_00535 ENOG4105J7D transcriptional regulator CGK93_00540 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CGK93_00545 ENOG4108IND Tetr family transcriptional regulator CGK93_00555 ENOG4108Z0Z intracellular protease Pfpi family CGK93_00575 ENOG4105ETE Transcriptional regulator (LacI family CGK93_00580 ENOG4105CS2 ec 3.2.1.21 CGK93_00585 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component CGK93_00610 ENOG4105CJ1 ABC, transporter CGK93_00620 ENOG4105WH1 Two component transcriptional regulator luxr family CGK93_00625 ENOG4105BZU Histidine kinase CGK93_00630 ENOG4105BZU Histidine kinase CGK93_00640 ENOG4105C2W permease CGK93_00645 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) CGK93_00670 ENOG4105DUX Transporter CGK93_00675 ENOG4105DV0 amidase (EC 3.5.1.4 CGK93_00680 ENOG4105EC3 peptidase S51, dipeptidase E CGK93_00685 ENOG4105VFE sira family CGK93_00690 ENOG4105CQC Prephenate dehydratase CGK93_00700 ENOG4107TE5 Lipid kinase CGK93_00705 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CGK93_00725 ENOG4105EEM helicase CGK93_00730 ENOG4105DQF Hydrolase CGK93_00750 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CGK93_00760 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CGK93_00765 ENOG4105DKP glycosyl transferase, family 9 CGK93_00775 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CGK93_00780 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) CGK93_00785 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) CGK93_00790 ENOG4106517 Short-chain dehydrogenase reductase Sdr CGK93_00800 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) CGK93_00870 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CGK93_00885 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CGK93_00890 ENOG4105EUJ GTP cyclohydrolase i CGK93_00905 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CGK93_00930 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CGK93_01010 ENOG4105CRK lysyL-tRNA synthetase CGK93_01020 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CGK93_01030 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein CGK93_01060 ENOG4108RWI nicotinamidase CGK93_01065 ENOG4105CMT Dihydroxyacetone kinase CGK93_01070 ENOG4108UTZ Dihydroxyacetone kinase CGK93_01075 ENOG4105VDH Dihydroxyacetone kinase CGK93_01080 ENOG41067RQ csbd family CGK93_01105 ENOG4105CK2 sodium dicarboxylate symporter CGK93_01115 ENOG4105CEN a g-specific adenine glycosylase CGK93_01125 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) CGK93_01135 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CGK93_01140 ENOG4105EIG urea carboxylase-associated protein 1 CGK93_01170 ENOG410841Q phosphoesterase PA-phosphatase related protein CGK93_01195 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CGK93_01260 ENOG4105ETE Transcriptional regulator (LacI family CGK93_01295 ENOG4108YZ9 Urea amidohydrolase subunit gamma CGK93_01300 ENOG4105KI2 Urea amidohydrolase subunit beta CGK93_01305 ENOG4105CQM Urea amidohydrolase subunit alpha CGK93_01310 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) CGK93_01315 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CGK93_01320 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) CGK93_01325 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CGK93_01330 ENOG4105D9G High-affinity CGK93_01340 ENOG4105K6V RNA polymerase CGK93_01370 ENOG4105CV8 reductase CGK93_01380 ENOG4105CPC Aldo Keto reductase CGK93_01385 ENOG4105CV8 reductase CGK93_01395 ENOG4105WKW Pfam:DUF1458 CGK93_01400 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CGK93_01415 ENOG4106IPI cyclase, family CGK93_01420 ENOG4105EWK phytoene CGK93_01440 ENOG4105ECQ AraC Family Transcriptional Regulator CGK93_01450 ENOG4107EJG GntR family transcriptional regulator CGK93_01455 ENOG4108MUZ hydrolase CGK93_01465 ENOG4105ZXK Dehydrogenase CGK93_01470 ENOG4105C6Z Gluconate CGK93_01525 ENOG4105DY8 decarboxylase CGK93_01530 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) CGK93_01550 ENOG4105CHR reductase CGK93_01560 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) CGK93_01570 ENOG4105XYF acetyltransferase CGK93_01575 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase CGK93_01595 ENOG4105CSH Transporter CGK93_01600 ENOG4105DZR Type I site-specific deoxyribonuclease CGK93_01610 ENOG4105CVR type I restriction-modification system CGK93_01640 ENOG4105DQE DNA ligase CGK93_01645 ENOG4105FDF Could be involved in DNA repair (By similarity) CGK93_01675 ENOG4105IIP Membrane CGK93_01680 ENOG4105W1N transcriptional regulator CGK93_01690 ENOG4105DM4 PTS System CGK93_01700 ENOG4105E98 transcriptional regulator DeoR family CGK93_01720 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) CGK93_01745 ENOG4107UVD Beta-phosphoglucomutase family hydrolase CGK93_01770 ENOG4105E5Q amino acid AbC transporter CGK93_01775 ENOG4105CDA abc transporter atp-binding protein CGK93_01815 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase CGK93_01855 ENOG4105EWK phytoene CGK93_01865 ENOG4105EAH synthase CGK93_01870 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) CGK93_01900 ENOG4105ERH Fumarylacetoacetate hydrolase CGK93_01915 ENOG4105D2S major facilitator superfamily CGK93_01925 ENOG4105F1N DNA alkylation repair CGK93_01935 ENOG4105C01 Dihydroxy-acid dehydratase CGK93_01950 ENOG4105WH1 Two component transcriptional regulator luxr family CGK93_01965 ENOG4107AQZ Membrane CGK93_01985 ENOG4105CSV Glutaminase CGK93_02005 ENOG4105E7W lamb ycsf family protein CGK93_02025 ENOG4106BRA Membrane CGK93_02095 ENOG4105BZ1 (ABC) transporter CGK93_02100 ENOG4105BZ1 (ABC) transporter CGK93_02105 ENOG4105R1U AraC Family Transcriptional Regulator CGK93_02120 ENOG4105DQ5 transport system permease protein CGK93_02130 ENOG4105E0A ABC, transporter CGK93_02135 ENOG4105CR8 Transcriptional regulator CGK93_02150 ENOG4105KVH Transcriptional regulator CGK93_02155 ENOG4105ECR NmrA family CGK93_02160 ENOG4105C85 amino acid CGK93_02175 ENOG4105CGP Urocanate hydratase CGK93_02180 ENOG4105C84 Histidine ammonia-lyase CGK93_02205 ENOG41088SP formiminoglutamate hydrolase CGK93_02210 ENOG4105C7N Xanthine uracil vitamin C permease CGK93_02235 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CGK93_02240 ENOG4105PGM cation diffusion facilitator family transporter CGK93_02250 ENOG4105D7K pfkb domain protein CGK93_02285 ENOG4105VBF alkaline shock protein CGK93_02310 ENOG4105DME alpha-galactosidase CGK93_02330 ENOG4105EPJ extracellular solute-binding protein family 1 CGK93_02335 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component CGK93_02340 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component CGK93_02345 ENOG4105ETE Transcriptional regulator (LacI family CGK93_02365 ENOG4105WH1 Two component transcriptional regulator luxr family CGK93_02370 ENOG4105ENE Histidine kinase CGK93_02385 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CGK93_02395 ENOG4105D6N CoA-transferase, subunit a CGK93_02435 ENOG4105C94 Transporter CGK93_02450 ENOG4105E2A Dehydrogenase CGK93_02460 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CGK93_02465 ENOG410908R Methenyltetrahydrofolate cyclohydrolase CGK93_02480 ENOG4105DRR Transcriptional regulator, GntR family CGK93_02485 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) CGK93_02495 ENOG4107RSM transcriptional regulator CGK93_02520 ENOG4105CVP deoxyribo-dipyrimidine photolyase CGK93_02525 ENOG4105C26 Dehydrogenase CGK93_02530 ENOG4105E39 Enoyl-CoA hydratase CGK93_02595 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CGK93_02600 ENOG4105C1G acyl-Coa dehydrogenase CGK93_02635 ENOG410829K Lysine exporter protein (Lyse ygga) CGK93_02680 ENOG4105C2J ABC transporter CGK93_02685 ENOG4105CNN ABC, transporter CGK93_02690 ENOG4107R5G Periplasmic binding protein LacI transcriptional regulator CGK93_02705 ENOG4108HKT sucrose-6-phosphate hydrolase CGK93_02710 ENOG4105E9Z Nad-dependent epimerase dehydratase CGK93_02720 ENOG4108Z6Z Transcriptional regulator CGK93_02735 ENOG4105C26 Dehydrogenase CGK93_02740 ENOG4108Z86 Glutamine amidotransferase CGK93_02750 ENOG4105CUB amino acid CGK93_02755 ENOG41073TP transcriptional regulator CGK93_02760 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR CGK93_02765 ENOG4105EAB amino acid AbC transporter CGK93_02770 ENOG4105EAD ABC transporter CGK93_02775 ENOG4105CDA abc transporter atp-binding protein CGK93_02780 ENOG4105KME endoribonuclease L-psp CGK93_02785 ENOG4105MWK D-amino acid dehydrogenase, small subunit CGK93_02795 ENOG4105ETE Transcriptional regulator (LacI family CGK93_02810 ENOG4105DEF Extracellular solute-binding protein, family 5 CGK93_02825 ENOG4108JQ6 ABC transporter CGK93_02835 ENOG4105CK5 oxidoreductase CGK93_02840 ENOG4105ETE Transcriptional regulator (LacI family CGK93_02845 ENOG4105D2H Uronic isomerase CGK93_02850 ENOG4105DEI Mannitol dehydrogenase CGK93_02855 ENOG4105CXK mandelate racemase muconate lactonizing CGK93_02860 ENOG4105D17 glycoside hydrolase, family 3 domain protein CGK93_02865 ENOG4105DFW ABC transporter CGK93_02870 ENOG4105C2J ABC transporter CGK93_02875 ENOG4108HWW ABC transporter CGK93_02880 ENOG4105ETE Transcriptional regulator (LacI family CGK93_02885 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CGK93_02930 ENOG4105E0A ABC, transporter CGK93_02935 ENOG4105TVJ transport system, permease CGK93_02940 ENOG4105DQ5 transport system permease protein CGK93_02945 ENOG4108MES Periplasmic binding protein CGK93_02980 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CGK93_03015 ENOG4108IG5 Transcriptional regulator CGK93_03050 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) CGK93_03055 ENOG4105DUM transcriptional regulator, lysR family CGK93_03060 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CGK93_03065 ENOG4105CSH Transporter CGK93_03080 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) CGK93_03100 ENOG4105C26 Dehydrogenase CGK93_03110 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CGK93_03120 ENOG4106PMH Extracellular solute-binding protein family 3 CGK93_03125 ENOG4105EAD ABC transporter CGK93_03130 ENOG4105CDA abc transporter atp-binding protein CGK93_03135 ENOG4105D9R oxidoreductase CGK93_03180 ENOG4105K4P CoA-binding domain protein CGK93_03190 ENOG4105MSB protein, conserved in bacteria CGK93_03205 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CGK93_03230 ENOG4105EFA 4-hydroxyphenylacetate CGK93_03275 ENOG4105BZU Histidine kinase CGK93_03285 ENOG4105BZU Histidine kinase CGK93_03290 ENOG4107QIK phosphoribosylformylglycinamidine synthase CGK93_03295 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CGK93_03315 ENOG4105WEF catalase CGK93_03320 ENOG4105C5I Dehydrogenase CGK93_03350 ENOG4105K56 Transcriptional regulator CGK93_03365 ENOG4105E90 ABC transporter CGK93_03370 ENOG4108IJ8 ABC transporter CGK93_03375 ENOG4105E90 ABC transporter CGK93_03380 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system CGK93_03390 ENOG4107WEA mandelate racemase muconate lactonizing CGK93_03395 ENOG4105C26 Dehydrogenase CGK93_03400 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CGK93_03415 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase CGK93_03425 ENOG41060H3 Protein of unknown function (DUF1049) CGK93_03435 ENOG4107QK4 glycoside hydrolase, family 3 domain protein CGK93_03440 ENOG4107QNK )-transporter CGK93_03450 ENOG4105CFH Aspartokinase CGK93_03470 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CGK93_03485 ENOG4105EGD dinuclear metal center protein, YbgI family CGK93_03500 ENOG4105C26 Dehydrogenase CGK93_03525 ENOG4105E4C Lytic transglycosylase catalytic CGK93_03530 ENOG4108V06 Glutathione peroxidase CGK93_03585 ENOG4105ETE Transcriptional regulator (LacI family CGK93_03590 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CGK93_03600 ENOG4105ETE Transcriptional regulator (LacI family CGK93_03610 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CGK93_03615 ENOG4105DRS transport system, permease CGK93_03630 ENOG4105E2K Glycosyl transferase (Group 1 CGK93_03655 ENOG4108HKT sucrose-6-phosphate hydrolase CGK93_03660 ENOG4105ETE Transcriptional regulator (LacI family CGK93_03690 ENOG4108HKT sucrose-6-phosphate hydrolase CGK93_03695 ENOG4105SHT UspA domain-containing protein CGK93_03715 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CGK93_03720 ENOG4108MRH transcriptional regulatory protein CGK93_03735 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CGK93_03750 ENOG4105KPY Small multidrug resistance protein CGK93_03755 ENOG4107Y2X deaminase CGK93_03760 ENOG4107ZXU DSBA oxidoreductase CGK93_03775 ENOG41090KN UPF0303 protein CGK93_03795 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CGK93_03835 ENOG4108Q5F Tetr family transcriptional regulator CGK93_03845 ENOG4105DWF phosphomethylpyrimidine kinase CGK93_03855 ENOG4105DHQ Histidine kinase CGK93_03860 ENOG4108KXV response regulator CGK93_03865 ENOG4105CSH Transporter CGK93_03870 ENOG4105ECP epimerase CGK93_03885 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CGK93_03925 ENOG4105C1G acyl-Coa dehydrogenase CGK93_03955 ENOG4107W19 lmbE family CGK93_03965 ENOG4107QJZ Glycosyl transferase, family 2 CGK93_03980 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) CGK93_03990 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN CGK93_03995 ENOG4108UVJ appr-1-p processing domain protein CGK93_04000 ENOG4108W1A pseudouridine synthase CGK93_04030 ENOG4108VW9 Membrane CGK93_04045 ENOG4107QZ7 Cellulose synthase catalytic subunit CGK93_04055 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) CGK93_04060 ENOG4107QRT dEAD DEAH box helicase CGK93_04085 ENOG4108UGD Serine Threonine protein kinase CGK93_04160 ENOG4107STW synthase CGK93_04170 ENOG4108Z6B deaminase CGK93_04175 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CGK93_04200 ENOG4105BZU Histidine kinase CGK93_04205 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CGK93_04215 ENOG4105M4E phosphohistidine phosphatase, SixA CGK93_04225 ENOG4105EMY transcriptional regulator CGK93_04230 ENOG4108594 Permease of the drug metabolite transporter CGK93_04245 ENOG4105EFZ amidohydrolase CGK93_04255 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CGK93_04265 ENOG4108JQ5 ABC transporter CGK93_04270 ENOG4105CJP fad dependent oxidoreductase CGK93_04280 ENOG4108IG5 Transcriptional regulator CGK93_04285 ENOG4105ECB domain protein CGK93_04295 ENOG4107QN2 dihydrolipoyl dehydrogenase CGK93_04300 ENOG4105KHC sulfurtransferase CGK93_04305 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) CGK93_04310 ENOG4105DKQ ROK family CGK93_04320 ENOG4108JQ7 (ABC) transporter CGK93_04335 ENOG4105DEF Extracellular solute-binding protein, family 5 CGK93_04355 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) CGK93_04380 ENOG4105C9U ATP-dependent DNA helicase RecQ CGK93_04385 ENOG4105C0R drug resistance transporter emrb qaca subfamily CGK93_04435 ENOG4105D22 carbon starvation protein CGK93_04445 ENOG4108VC7 Protein of unknown function (DUF2587) CGK93_04455 ENOG4105CV8 reductase CGK93_04465 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CGK93_04480 ENOG4105CH2 amidohydrolase CGK93_04505 ENOG4105C6E dna polymerase iii CGK93_04510 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CGK93_04530 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CGK93_04540 ENOG4105BZU Histidine kinase CGK93_04560 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CGK93_04565 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CGK93_04575 ENOG4105C8N cysteinyl-tRNA synthetase CGK93_04610 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) CGK93_04620 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CGK93_04650 ENOG4105ETE Transcriptional regulator (LacI family CGK93_04665 ENOG4105D56 permease protein CGK93_04670 ENOG4105EG2 ABC transporter, permease CGK93_04675 ENOG4107R28 alpha amylase, catalytic region CGK93_04680 ENOG4105CQB FAD linked oxidase domain protein CGK93_04695 ENOG4105DZC cytosine deaminase CGK93_04710 ENOG4105E2D ec 3.2.1.52 CGK93_04715 ENOG4108IJ9 (ABC) transporter CGK93_04740 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CGK93_04750 ENOG4105DEN Luciferase family CGK93_04770 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CGK93_04775 ENOG4105F27 Major Facilitator CGK93_04885 ENOG4107T5V SNARE associated Golgi CGK93_04890 ENOG4105ETE Transcriptional regulator (LacI family CGK93_04895 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CGK93_04900 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CGK93_04915 ENOG4108HKT sucrose-6-phosphate hydrolase CGK93_04925 ENOG4105C9U ATP-dependent DNA helicase RecQ CGK93_04930 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CGK93_04940 ENOG4108JU3 Alkyl hydroperoxide reductase CGK93_04980 ENOG4105CHR reductase CGK93_04990 ENOG4105C1G acyl-Coa dehydrogenase CGK93_05015 ENOG4105D5U fad dependent oxidoreductase CGK93_05055 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CGK93_05070 ENOG4105C3M thioredoxin reductase CGK93_05080 ENOG4105CH2 amidohydrolase CGK93_05090 ENOG4105C57 major facilitator superfamily CGK93_05100 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CGK93_05105 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CGK93_05110 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CGK93_05150 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CGK93_05170 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CGK93_05185 ENOG4105BZU Histidine kinase CGK93_05190 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CGK93_05200 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CGK93_05210 ENOG4107R16 Multicopper oxidase CGK93_05235 ENOG4105VEQ Cold shock protein CGK93_05245 ENOG4107SFI Major Facilitator superfamily CGK93_05250 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CGK93_05260 ENOG4105DR5 peptidase CGK93_05280 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CGK93_05295 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CGK93_05315 ENOG4105CDA abc transporter atp-binding protein CGK93_05340 ENOG4105C5H ABC transporter CGK93_05345 ENOG4105BZ1 (ABC) transporter CGK93_05375 ENOG4105ECY inositol monophosphatase CGK93_05400 ENOG4105CMV Succinyl-CoA synthetase subunit beta CGK93_05415 ENOG4108Z86 Glutamine amidotransferase CGK93_05455 ENOG4108JCI Transcriptional regulator CGK93_05470 ENOG4105C7K acetolactate synthase CGK93_05500 ENOG4106N3A copper homeostasis protein cutc CGK93_05535 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CGK93_05540 ENOG4105I1K ABC transporter CGK93_05545 ENOG4105ETE Transcriptional regulator (LacI family CGK93_05560 ENOG4105ETE Transcriptional regulator (LacI family CGK93_05590 ENOG4105CMR udp-glucose 4-epimerase CGK93_05620 ENOG4105E4C Lytic transglycosylase catalytic CGK93_05630 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 CGK93_05645 ENOG4105BZU Histidine kinase CGK93_05650 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CGK93_05670 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CGK93_05685 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CGK93_05720 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CGK93_05735 ENOG4105CMT Dihydroxyacetone kinase CGK93_05740 ENOG4107YVI ribose 5-phosphate isomerase CGK93_05745 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CGK93_05755 ENOG4105CSP Major Facilitator Superfamily CGK93_05760 ENOG4105CP7 Triose-phosphate isomerase CGK93_05815 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) CGK93_05820 ENOG41086YM Acylphosphatase CGK93_05825 ENOG4105YXB Toxic component of a toxin-antitoxin (TA) module. A CGK93_05835 ENOG4108RVA ribokinase CGK93_05840 ENOG4105C6F GntR Family Transcriptional Regulator CGK93_05850 ENOG4105DU0 nucleoside hydrolase CGK93_05855 ENOG4105NPE arsR family transcriptional regulator CGK93_05870 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CGK93_05885 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CGK93_05920 ENOG4108428 Inherit from COG: -acetyltransferase CGK93_05925 ENOG4107QK4 glycoside hydrolase, family 3 domain protein CGK93_05930 ENOG4105CK5 oxidoreductase CGK93_05945 ENOG4105ETE Transcriptional regulator (LacI family CGK93_05965 ENOG4105M2Z protein tyrosine serine phosphatase CGK93_05985 ENOG41080V3 Major Facilitator superfamily CGK93_06000 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CGK93_06010 ENOG41082JN Transcriptional regulator CGK93_06080 ENOG4108ZT1 Transcriptional regulator CGK93_06085 ENOG4108KTG Membrane protein, drug metabolite transporter CGK93_06125 ENOG4105E6M Sulphatase-modifying factor protein CGK93_06140 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 CGK93_06185 ENOG4105CUB amino acid CGK93_06215 ENOG4105VEQ Cold shock protein CGK93_06230 ENOG4105EV4 Multidrug resistance protein mdtH CGK93_06235 ENOG4105D0M Protease HtpX homolog CGK93_06250 ENOG4105C6Y Udp-glucose 6-dehydrogenase CGK93_06275 ENOG4105KNI merR family transcriptional Regulator CGK93_06285 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CGK93_06320 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CGK93_06330 ENOG4105DC1 bifunctional purine biosynthesis protein purh CGK93_06345 ENOG4105E9K Isocitrate dehydrogenase CGK93_06360 ENOG4105D5T phosphonate abc transporter CGK93_06380 ENOG4108KAZ Involved in phosphonate degradation (By similarity) CGK93_06410 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CGK93_06415 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CGK93_06420 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CGK93_06425 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CGK93_06430 ENOG4105DFW ABC transporter CGK93_06435 ENOG41062B0 ABC transporter, permease CGK93_06440 ENOG4105C2J ABC transporter CGK93_06450 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) CGK93_06460 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CGK93_06465 ENOG4105CUB amino acid CGK93_06475 ENOG4108Z0R Transferase CGK93_06495 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CGK93_06500 ENOG4105CJ1 ABC, transporter CGK93_06535 ENOG4105C31 Tryptophanyl-tRNA synthetase CGK93_06570 ENOG4105E33 succinate dehydrogenase CGK93_06590 ENOG4105CJT Mannose-1-phosphate guanylyltransferase CGK93_06595 ENOG4107RM1 amidohydrolase CGK93_06600 ENOG4105K56 Transcriptional regulator CGK93_06605 ENOG4108ZHJ Organic hydroperoxide resistance protein CGK93_06610 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CGK93_06615 ENOG4105DIH basic membrane CGK93_06620 ENOG4108JQ9 ABC transporter CGK93_06625 ENOG4105UIB (ABC) transporter CGK93_06650 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN CGK93_06655 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) CGK93_06660 ENOG4105DXN mazG family CGK93_06665 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CGK93_06715 ENOG4108IV0 ABC, transporter CGK93_06720 ENOG4105C0Z ABC transporter CGK93_06725 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CGK93_06730 ENOG4105C32 Amino acid ABC transporter (Permease) CGK93_06745 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CGK93_06755 ENOG4107WI4 Aldose-1-epimerase CGK93_06765 ENOG4105C7B Threonine dehydratase CGK93_06775 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CGK93_06785 ENOG4105T1M mycothiol conjugate amidase mca CGK93_06795 ENOG4105C7Z Conserved Protein CGK93_06800 ENOG4108UT2 hemolysin iii CGK93_06805 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CGK93_06810 ENOG4108IAB Phoh family CGK93_06845 ENOG4105C9Q fumarate hydratase class II CGK93_06850 ENOG4108V9Q carbonic anhydrase CGK93_06870 ENOG4105EIP mannose-6-phosphate isomerase CGK93_06900 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CGK93_06905 ENOG4107RGC Glycosyl transferase, family 2 CGK93_06930 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) CGK93_06945 ENOG4105DDN Pentapeptide repeat-containing protein CGK93_07000 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CGK93_07005 ENOG4105F8V Hydrolase, tatD family CGK93_07010 ENOG4106839 domain protein CGK93_07015 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CGK93_07020 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CGK93_07025 ENOG4105C5H ABC transporter CGK93_07035 ENOG41067SE Tetr family transcriptional regulator CGK93_07045 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CGK93_07050 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CGK93_07055 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CGK93_07060 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CGK93_07105 ENOG4105CGD Nad-dependent epimerase dehydratase CGK93_07115 ENOG4107K5X Membrane-bound metal-dependent hydrolase CGK93_07125 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CGK93_07175 ENOG4105NAE bifunctional deaminase-reductase domain protein CGK93_07185 ENOG4105KT5 UmuD protein CGK93_07210 ENOG4105C3M thioredoxin reductase CGK93_07235 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CGK93_07245 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CGK93_07255 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CGK93_07270 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain CGK93_07275 ENOG4108HKT sucrose-6-phosphate hydrolase CGK93_07280 ENOG4105EDQ levansucrase EC 2.4.1.10 CGK93_07305 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CGK93_07310 ENOG4105DQQ Major facilitator superfamily MFS_1 CGK93_07315 ENOG4105CSH Transporter CGK93_07320 ENOG4108JIK carboxylase CGK93_07325 ENOG4107WR6 Maf-like protein CGK93_07330 ENOG4105EYF MMPL domain protein CGK93_07335 ENOG41060BG Tetr family transcriptional regulator CGK93_07340 ENOG41082VC UPF0145 protein CGK93_07345 ENOG4108ETY sodium dicarboxylate symporter CGK93_07395 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CGK93_07420 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CGK93_07440 ENOG4108ZF3 Phosphatase CGK93_07460 ENOG4105EC2 ftsk spoIIIe CGK93_07470 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CGK93_07485 ENOG4105CPU Monooxygenase CGK93_07500 ENOG4108MRH transcriptional regulatory protein CGK93_07510 ENOG4105D4T Citrate transporter CGK93_07515 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CGK93_07520 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CGK93_07525 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CGK93_07535 ENOG4105E6M Sulphatase-modifying factor protein CGK93_07545 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CGK93_07555 ENOG4105ETE Transcriptional regulator (LacI family CGK93_07570 ENOG4105CPQ Dehydrogenase CGK93_07575 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CGK93_07590 ENOG4105CI2 imidazolone-5-propionate hydrolase CGK93_07595 ENOG4105ESP cell wall surface anchor family protein CGK93_07600 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CGK93_07605 ENOG4105DKQ ROK family CGK93_07615 ENOG4105D2N Aldolase CGK93_07640 ENOG4108IQK o-acetylhomoserine CGK93_07645 ENOG4105DWV Homoserine O-trans-acetylase CGK93_07680 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CGK93_07700 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein CGK93_07705 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CGK93_07725 ENOG4108SEA Esterase CGK93_07730 ENOG4105FF5 Membrane CGK93_07740 ENOG4105C2C drug resistance transporter, Bcr CflA CGK93_07750 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CGK93_07770 ENOG4105C1G acyl-Coa dehydrogenase CGK93_07780 ENOG4105CE9 30S ribosomal protein S2 CGK93_07785 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CGK93_07790 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CGK93_07795 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CGK93_07800 ENOG4105KNE Phosphatidate cytidylyltransferase CGK93_07825 ENOG4105DY9 regulatoR CGK93_07830 ENOG4108HRK Histidine kinase CGK93_07840 ENOG4107QN1 sodium solute CGK93_07845 ENOG4105DCG PHP domain protein CGK93_07865 ENOG4108YXU transcriptional regulator AsnC family CGK93_07875 ENOG4105CPP Dehydrogenase, E1 component CGK93_07880 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 CGK93_07885 ENOG4105C1B dTDP-glucose 4-6-dehydratase CGK93_07900 ENOG4107QX3 carboxylase CGK93_07910 ENOG4105C1G acyl-Coa dehydrogenase CGK93_07935 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CGK93_07955 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CGK93_07960 ENOG4105XN3 extracellular solute-binding protein family 1 CGK93_07965 ENOG4105ETE Transcriptional regulator (LacI family CGK93_07975 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CGK93_07980 ENOG4105DZP Membrane-associated zinc metalloprotease CGK93_07990 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CGK93_08005 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CGK93_08015 ENOG4108Q27 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) CGK93_08035 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) CGK93_08050 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CGK93_08055 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CGK93_08060 ENOG4107Y2X deaminase CGK93_08070 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CGK93_08090 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CGK93_08095 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CGK93_08100 ENOG4105C1V Peptidase, M16 CGK93_08120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CGK93_08125 ENOG41065SU Two-component system sensor kinase CGK93_08145 ENOG4108RIR Molybdenum cofactor biosynthesis protein CGK93_08155 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CGK93_08180 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CGK93_08185 ENOG4105CN5 Metallo-Beta-Lactamase CGK93_08190 ENOG4107QZI cell division protein FtsK CGK93_08200 ENOG4105CEV competence damage-inducible protein CGK93_08205 ENOG4105WBV Transcriptional regulator CGK93_08220 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CGK93_08225 ENOG4105KC9 Modulates RecA activity (By similarity) CGK93_08230 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CGK93_08235 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CGK93_08240 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CGK93_08245 ENOG4107Y49 methyltransferase CGK93_08250 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CGK93_08260 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CGK93_08265 ENOG41067Z0 domain protein CGK93_08270 ENOG4105CIH Imidazole acetol-phosphate transaminase CGK93_08275 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CGK93_08280 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CGK93_08285 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CGK93_08305 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CGK93_08310 ENOG41084BS 50S ribosomal protein L35 CGK93_08315 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CGK93_08320 ENOG4108RWN rrna methyltransferase CGK93_08325 ENOG4105F27 Major Facilitator CGK93_08340 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) CGK93_08360 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CGK93_08365 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CGK93_08370 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases CGK93_08430 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CGK93_08440 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CGK93_08445 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CGK93_08450 ENOG4105CAS nag kinase CGK93_08455 ENOG4105C8Y Acetylornithine aminotransferase CGK93_08460 ENOG4105DBV ornithine carbamoyltransferase CGK93_08465 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CGK93_08470 ENOG4105CDH Citrulline--aspartate ligase CGK93_08475 ENOG4105CH7 arginosuccinase CGK93_08490 ENOG4108VX5 3-methyladenine DNA glycosylase CGK93_08500 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CGK93_08525 ENOG4105DSU hydrolase CGK93_08540 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CGK93_08545 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CGK93_08550 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CGK93_08570 ENOG4108TIT dATP pyrophosphohydrolase CGK93_08580 ENOG4105CR4 methylisocitrate lyase CGK93_08605 ENOG4108MRH transcriptional regulatory protein CGK93_08610 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CGK93_08615 ENOG4105CK2 sodium dicarboxylate symporter CGK93_08625 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CGK93_08630 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CGK93_08645 ENOG4105CAT Cytidine monophosphate kinase CGK93_08655 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CGK93_08665 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) CGK93_08670 ENOG4105F27 Major Facilitator CGK93_08685 ENOG4108UW8 fha domain-containing protein CGK93_08710 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CGK93_08720 ENOG4105DKQ ROK family CGK93_08745 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase CGK93_08755 ENOG41068JE domain protein CGK93_08765 ENOG4105EAH synthase CGK93_08775 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CGK93_08785 ENOG4108V6E Cell division protein mraZ CGK93_08790 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CGK93_08800 ENOG4105CJN penicillin-binding protein CGK93_08805 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CGK93_08815 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CGK93_08820 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CGK93_08830 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CGK93_08835 ENOG4105DFU Cell wall formation (By similarity) CGK93_08845 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CGK93_08850 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CGK93_08855 ENOG4105DFA alanine racemase domain protein CGK93_08860 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CGK93_08875 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CGK93_08900 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CGK93_08905 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CGK93_08910 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CGK93_08935 ENOG4105C5F glutamine synthetase CGK93_08940 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) CGK93_08985 ENOG4105D7W serine acetyltransferase CGK93_08990 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CGK93_08995 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) CGK93_09005 ENOG4105ECP epimerase CGK93_09015 ENOG4108Z9K Osmotically inducible protein CGK93_09040 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CGK93_09060 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CGK93_09090 ENOG4105C4M (Ubiquinol oxidase) subunit I CGK93_09095 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CGK93_09100 ENOG4108JJ9 ABC, transporter CGK93_09120 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CGK93_09125 ENOG4105CD5 CoA-binding domain protein CGK93_09140 ENOG4107W53 thymidine kinase CGK93_09160 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CGK93_09185 ENOG4107VEG TrkA-N domain protein CGK93_09190 ENOG4105C0X amino acid CGK93_09195 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CGK93_09230 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CGK93_09235 ENOG4105CHU acetyl-coa acetyltransferase CGK93_09265 ENOG4105E0X reductase CGK93_09280 ENOG4108Z66 YbaK ebsC protein CGK93_09300 ENOG4105DKK Benzoate CGK93_09310 ENOG4105CUB amino acid CGK93_09400 ENOG4106178 UPF0339 protein CGK93_09505 ENOG41088T4 Helicase IV CGK93_09555 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CGK93_09560 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CGK93_09570 ENOG4105DJV ribulose-phosphate 3-epimerase CGK93_09590 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CGK93_09595 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CGK93_09600 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CGK93_09605 ENOG4105M0N phosphoribosyl-ATP pyrophosphatase CGK93_09610 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CGK93_09615 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CGK93_09625 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CGK93_09645 ENOG4105DK0 Indole-3-glycerol phosphate synthase CGK93_09650 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CGK93_09655 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CGK93_09660 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CGK93_09855 ENOG4105Z8H single-stranded DNA-binding protein CGK93_09900 ENOG4106J7G oxidoreductase CGK93_09905 ENOG4108KFM Xylose Isomerase Domain-Containing protein CGK93_09910 ENOG4105CP7 Triose-phosphate isomerase CGK93_09915 ENOG4107YVI ribose 5-phosphate isomerase CGK93_09920 ENOG4105CMT Dihydroxyacetone kinase CGK93_09925 ENOG4105JXH GntR family transcriptional regulator CGK93_09930 ENOG4108NQD CGK93_09935 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CGK93_09970 ENOG4107HP6 Transcriptional regulator CGK93_09985 ENOG4105EBR Carboxylesterase CGK93_09995 ENOG4105EBR Carboxylesterase CGK93_10010 ENOG4105EBR Carboxylesterase CGK93_10020 ENOG4105CS2 ec 3.2.1.21 CGK93_10065 ENOG4105D2S major facilitator superfamily CGK93_10075 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase CGK93_10080 ENOG4107HP6 Transcriptional regulator CGK93_10105 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CGK93_10115 ENOG4105D2S major facilitator superfamily CGK93_10125 ENOG4105CHR reductase CGK93_10155 ENOG4105FB2 class II Aldolase CGK93_10160 ENOG4105G9B Transcriptional regulator CGK93_10210 ENOG4105CHR reductase CGK93_10215 ENOG4105E09 nadh pyrophosphatase CGK93_10245 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) CGK93_10250 ENOG4105KPY Small multidrug resistance protein CGK93_10255 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CGK93_10260 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CGK93_10270 ENOG4108SQ9 flavin reductase domain protein, FMN-binding CGK93_10275 ENOG4105C28 cystathionine CGK93_10300 ENOG4105CUB amino acid CGK93_10310 ENOG4105EW9 transcriptional regulator AsnC family CGK93_10315 ENOG4108IJ0 Aspartate ammonia-lyase CGK93_10330 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) CGK93_10340 ENOG4108TVT permease CGK93_10350 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CGK93_10365 ENOG4106PMH Extracellular solute-binding protein family 3 CGK93_10380 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CGK93_10385 ENOG4105CNT hydrolase family 2 CGK93_10425 ENOG4105ETE Transcriptional regulator (LacI family CGK93_10430 ENOG4108KEZ Dehydrogenase CGK93_10455 ENOG4105DSG hydrolase family 43 CGK93_10480 ENOG4105NN7 muconolactone delta-isomerase CGK93_10485 ENOG4105DTQ mandelate racemase muconate lactonizing CGK93_10490 ENOG4108QMY dioxygenase CGK93_10495 ENOG4105FUY alpha subunit CGK93_10500 ENOG4108UKV benzoate 1,2-dioxygenase CGK93_10520 ENOG4107RSM transcriptional regulator CGK93_10525 ENOG4105D2S major facilitator superfamily CGK93_10575 ENOG4105EUF amidase EC 3.5.1.4 CGK93_10595 ENOG4105CI2 imidazolone-5-propionate hydrolase CGK93_10600 ENOG4105CI2 imidazolone-5-propionate hydrolase CGK93_10640 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CGK93_10650 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) CGK93_10655 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase CGK93_10660 ENOG4105JXH GntR family transcriptional regulator CGK93_10665 ENOG4105CD3 dihydroorotase CGK93_10670 ENOG4105DU0 nucleoside hydrolase CGK93_10680 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CGK93_10695 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CGK93_10710 ENOG4105CHR reductase CGK93_10740 ENOG4105DU0 nucleoside hydrolase CGK93_10750 ENOG41060NJ transcriptional regulator CGK93_10760 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) CGK93_10770 ENOG4105ETE Transcriptional regulator (LacI family CGK93_10785 ENOG4105CHR reductase CGK93_10790 ENOG4105CXK mandelate racemase muconate lactonizing CGK93_10800 ENOG4108I5D sulfate abc transporter CGK93_10820 ENOG4105JSC dimethylmenaquinone methyltransferase CGK93_10855 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CGK93_10860 ENOG4105ETE Transcriptional regulator (LacI family CGK93_10865 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) CGK93_10955 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 CGK93_10975 ENOG4105C0D helicase CGK93_11000 ENOG4107SET aldo keto reductase CGK93_11020 ENOG4108IV0 ABC, transporter CGK93_11025 ENOG4105C0Z ABC transporter CGK93_11030 ENOG410800I Aminomethyltransferase CGK93_11035 ENOG4105QPS Monooxygenase CGK93_11045 ENOG4105CHR reductase CGK93_11050 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CGK93_11065 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase CGK93_11070 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CGK93_11095 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CGK93_11105 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CGK93_11200 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CGK93_11205 ENOG4105EE5 Membrane protein terC CGK93_11285 ENOG4105DSF transport protein CGK93_11330 ENOG4105CPQ Dehydrogenase CGK93_11345 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CGK93_11370 ENOG4105CV8 reductase CGK93_11395 ENOG4105E2A Dehydrogenase CGK93_11400 ENOG4105E2A Dehydrogenase CGK93_11405 ENOG4105BZU Histidine kinase CGK93_11420 ENOG4105CIB oxidoreductase Domain protein CGK93_11430 ENOG4105CNN ABC, transporter CGK93_11435 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CGK93_11440 ENOG4107S8A protein TIM barrel CGK93_11450 ENOG4105C2J ABC transporter CGK93_11485 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CGK93_11490 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) CGK93_11495 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) CGK93_11520 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CGK93_11555 ENOG4108QBV Monogalactosyldiacylglycerol synthase CGK93_11565 ENOG4105CHM Aminotransferase CGK93_11600 ENOG4108IJ0 Aspartate ammonia-lyase CGK93_11615 ENOG4106F1P AAA ATPase, central domain protein CGK93_11620 ENOG4105CKW Inner membrane protein yedI CGK93_11625 ENOG4105ETE Transcriptional regulator (LacI family CGK93_11630 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CGK93_11635 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CGK93_11640 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CGK93_11650 ENOG4108JQ7 (ABC) transporter CGK93_11670 ENOG4105C7F AcnD-accessory protein PrpF CGK93_11690 ENOG4105DEF Extracellular solute-binding protein, family 5 CGK93_11715 ENOG4107RY6 amino acid CGK93_11735 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CGK93_11740 ENOG4107RWR Sodium hydrogen exchanger CGK93_11755 ENOG4105C7K acetolactate synthase CGK93_11775 ENOG4105E0A ABC, transporter CGK93_11780 ENOG4108HUF Transporter CGK93_11785 ENOG4105S6R Iron-hydroxamate transporter permease subunit CGK93_11800 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CGK93_11825 ENOG4105ERH Fumarylacetoacetate hydrolase CGK93_11845 ENOG4105ERH Fumarylacetoacetate hydrolase CGK93_11855 ENOG4108SC4 )-transporter CGK93_11870 ENOG4105NAE bifunctional deaminase-reductase domain protein CGK93_11880 ENOG4105QPS Monooxygenase CGK93_11885 ENOG4105HFS 5'-3' exonuclease CGK93_11920 ENOG4105CQ7 ATP-dependent helicase CGK93_11925 ENOG4105CI2 imidazolone-5-propionate hydrolase CGK93_11965 ENOG4107RTD sua5 ycio yrdc ywlc family protein CGK93_11975 ENOG4105CJ1 ABC, transporter CGK93_12025 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) CGK93_12060 ENOG4105KA0 thioesterase Superfamily protein CGK93_12070 ENOG4105HHS UPF0256 protein CGK93_12080 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CGK93_12085 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CGK93_12090 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CGK93_12095 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CGK93_12105 ENOG4105DXI Major Facilitator superfamily CGK93_12130 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) CGK93_12140 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CGK93_12145 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CGK93_12155 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CGK93_12160 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CGK93_12170 ENOG4105CIE May be required for sporulation (By similarity) CGK93_12180 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CGK93_12185 ENOG4105BZA Phosphoglycerate kinase CGK93_12190 ENOG4105CP7 Triose-phosphate isomerase CGK93_12205 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) CGK93_12220 ENOG4105C89 phosphohexose isomerase CGK93_12225 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CGK93_12235 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CGK93_12260 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CGK93_12265 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) CGK93_12270 ENOG4105KCT ABC transporter CGK93_12275 ENOG4105CJ1 ABC, transporter CGK93_12290 ENOG4105JRK feS assembly protein SufD CGK93_12300 ENOG4105C3K feS assembly ATPase SufC CGK93_12305 ENOG4105VG1 fes assembly suf system protein CGK93_12315 ENOG4105CEY Amp-dependent synthetase and ligase CGK93_12330 ENOG4108JJB ABC transporter CGK93_12335 ENOG4107ZYJ bioY protein CGK93_12340 ENOG4105C5H ABC transporter CGK93_12365 ENOG4105CHR reductase CGK93_12370 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CGK93_12375 ENOG4105C2J ABC transporter CGK93_12385 ENOG4105EAC phosphoserine phosphatase CGK93_12390 ENOG4105DKW ABC transporter CGK93_12405 ENOG4105NRA 50s ribosomal protein l31 type b CGK93_12420 ENOG4107ZR7 Membrane CGK93_12445 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CGK93_12450 ENOG4107QPH glycogen) synthase CGK93_12465 ENOG4105CHU acetyl-coa acetyltransferase CGK93_12470 ENOG4105CHR reductase CGK93_12485 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CGK93_12505 ENOG4105D3Q Sugar transferase CGK93_12520 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CGK93_12530 ENOG4108SHN Glycosyl transferase, family 2 CGK93_12575 ENOG4105C1B dTDP-glucose 4-6-dehydratase CGK93_12580 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CGK93_12585 ENOG4105CPC Aldo Keto reductase CGK93_12590 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CGK93_12595 ENOG4105C8N cysteinyl-tRNA synthetase CGK93_12605 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 CGK93_12620 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) CGK93_12625 ENOG4105E5F proteasome CGK93_12630 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) CGK93_12635 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) CGK93_12640 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) CGK93_12645 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) CGK93_12650 ENOG4108V1T peptidylprolyl cis-trans isomerase CGK93_12675 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CGK93_12680 ENOG4105CQR helicase CGK93_12685 ENOG4105EFZ amidohydrolase CGK93_12690 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) CGK93_12715 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein CGK93_12720 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CGK93_12740 ENOG41065KQ synthase CGK93_12745 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CGK93_12760 ENOG4108X79 transcriptional regulator CGK93_12765 ENOG4105DH8 myo-inositol catabolism CGK93_12770 ENOG4105CK5 oxidoreductase CGK93_12775 ENOG4105CK5 oxidoreductase CGK93_12780 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CGK93_12785 ENOG4105C2J ABC transporter CGK93_12790 ENOG41062B0 ABC transporter, permease CGK93_12800 ENOG4105ETE Transcriptional regulator (LacI family CGK93_12820 ENOG4107QNK )-transporter CGK93_12825 ENOG4105F0H myo-inositol catabolism protein CGK93_12830 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CGK93_12835 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CGK93_12840 ENOG4105C26 Dehydrogenase CGK93_12845 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) CGK93_12855 ENOG4105D7K pfkb domain protein CGK93_12860 ENOG41090U3 tautomerase CGK93_12890 ENOG4108I0Q anthranilate phosphoribosyltransferase CGK93_12895 ENOG4105CCU oxidase (Subunit III) CGK93_12900 ENOG4107UDY cytochrome C CGK93_12905 ENOG4107EUI c reductase, iron-sulfur CGK93_12910 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CGK93_12915 ENOG4105FDP GntR family transcriptional regulator CGK93_12920 ENOG410849S phosphocarrier protein (HPr) CGK93_12925 ENOG4108ZRS Part of cytochrome c oxidase, its function is CGK93_12930 ENOG4105BZ9 Cytochrome C oxidase, subunit I CGK93_12935 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) CGK93_12955 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CGK93_12970 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CGK93_12975 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) CGK93_12980 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CGK93_12985 ENOG4105C9K Endothelin-converting enzyme 1 CGK93_12990 ENOG4108KGH TRANSCRIPTIONal CGK93_12995 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CGK93_13005 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CGK93_13020 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CGK93_13025 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CGK93_13030 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CGK93_13050 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CGK93_13060 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) CGK93_13080 ENOG4105EPR degv family CGK93_13085 ENOG4105C8T Leucyl-tRNA synthetase CGK93_13090 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CGK93_13095 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CGK93_13105 ENOG4105DKT Transcriptional regulator CGK93_13110 ENOG4105CV8 reductase CGK93_13120 ENOG4105E2K Glycosyl transferase (Group 1 CGK93_13130 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CGK93_13140 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) CGK93_13145 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CGK93_13155 ENOG4105SKN orotidine 5''-phosphate decarboxylase CGK93_13160 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CGK93_13165 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CGK93_13175 ENOG4105CD3 dihydroorotase CGK93_13180 ENOG4105CXT aspartate transcarbamylase CGK93_13185 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CGK93_13195 ENOG410803B Involved in the transcription termination process (By similarity) CGK93_13200 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CGK93_13210 ENOG4105D49 3-dehydroquinate synthase CGK93_13215 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CGK93_13220 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CGK93_13225 ENOG4105E2X shikimate dehydrogenase CGK93_13235 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CGK93_13240 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CGK93_13255 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CGK93_13275 ENOG4105C9M aspartyl-trna synthetase CGK93_13280 ENOG4105CUT histidyl-tRNA synthetase CGK93_13290 ENOG4105C99 atpase involved in dna repair CGK93_13300 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CGK93_13305 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CGK93_13310 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CGK93_13320 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CGK93_13325 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CGK93_13330 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) CGK93_13335 ENOG4105CDY transcriptional regulatory protein CGK93_13340 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) CGK93_13360 ENOG4105DGW oligopeptidase A CGK93_13365 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) CGK93_13370 ENOG4108VTU Cdp-alcohol phosphatidyltransferase CGK93_13380 ENOG4105C22 threonyL-tRNA synthetase CGK93_13385 ENOG4105C0B DNA polymerase III (alpha subunit) CGK93_13410 ENOG4108RAV Conserved protein CGK93_13425 ENOG4105C5X domain protein CGK93_13480 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CGK93_13485 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CGK93_13490 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CGK93_13500 ENOG4107NQ8 LysR family Transcriptional regulator CGK93_13535 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CGK93_13555 ENOG4108JE9 extracellular solute-binding protein family 1 CGK93_13560 ENOG4105E2R ROK family CGK93_13565 ENOG4107RNR Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) CGK93_13580 ENOG41064MX Tetr family transcriptional regulator CGK93_13590 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) CGK93_13600 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CGK93_13610 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CGK93_13615 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CGK93_13620 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CGK93_13625 ENOG4105K46 50S ribosomal protein l27 CGK93_13630 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CGK93_13635 ENOG4105DWF phosphomethylpyrimidine kinase CGK93_13640 ENOG4105C03 ribonuclease CGK93_13650 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CGK93_13660 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CGK93_13665 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CGK93_13680 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CGK93_13690 ENOG4105MC2 DSBA oxidoreductase CGK93_13695 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CGK93_13700 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CGK93_13705 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CGK93_13710 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CGK93_13755 ENOG4105D8X mechanosensitive ion channel CGK93_13770 ENOG4105C29 acyl-CoA thioesterase CGK93_13815 ENOG4107JC6 Membrane CGK93_13820 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) CGK93_13830 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CGK93_13860 ENOG4107XFJ UPF0246 protein CGK93_13875 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CGK93_13885 ENOG4105D7W serine acetyltransferase CGK93_13890 ENOG4105E1F short-chain dehydrogenase reductase CGK93_13895 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CGK93_13905 ENOG4105CPQ Dehydrogenase CGK93_13910 ENOG4105CHR reductase CGK93_13920 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase CGK93_14055 ENOG4105CDU Replicative dna helicase CGK93_14060 ENOG4105CDU Replicative dna helicase CGK93_14310 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CGK93_14325 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CGK93_14330 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CGK93_14345 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CGK93_14355 ENOG4105C0P Mg chelatase subunit ChlI CGK93_14360 ENOG41080R2 UPF0102 protein CGK93_14370 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CGK93_14380 ENOG4107QYR Signal peptidase i CGK93_14385 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CGK93_14390 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CGK93_14395 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CGK93_14400 ENOG41082KU UPF0109 protein CGK93_14405 ENOG4105K5M 30s ribosomal protein S16 CGK93_14415 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CGK93_14425 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CGK93_14455 ENOG4105C6X Major Facilitator CGK93_14460 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CGK93_14490 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CGK93_14495 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CGK93_14500 ENOG41062IY 50S ribosomal protein L32 CGK93_14510 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CGK93_14525 ENOG4106H78 methyltransferase CGK93_14550 ENOG4105CPF Cell wall formation (By similarity) CGK93_14555 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CGK93_14565 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CGK93_14570 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CGK93_14575 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CGK93_14580 ENOG41069M3 Transcriptional regulator CGK93_14625 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CGK93_14630 ENOG4105CM2 brancheD-chain amino acid aminotransferase CGK93_14635 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CGK93_14640 ENOG4105BZU Histidine kinase CGK93_14645 ENOG4105WH1 Two component transcriptional regulator luxr family CGK93_14650 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CGK93_14660 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CGK93_14665 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CGK93_14675 ENOG4108JQ1 Dehydrogenase CGK93_14680 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CGK93_14685 ENOG4108ZP8 Acetolactate synthase small subunit CGK93_14695 ENOG4105C01 Dihydroxy-acid dehydratase CGK93_14700 ENOG4105C5Q Transcriptional regulator CGK93_14705 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CGK93_14740 ENOG4108J59 Extracellular solute-binding protein, family 5 CGK93_14745 ENOG4105DWT malate dehydrogenase (quinone) CGK93_14755 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CGK93_14790 ENOG4105ERH Fumarylacetoacetate hydrolase CGK93_14800 ENOG4107QI6 Cysteine desulfurase CGK93_14805 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CGK93_14815 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CGK93_14825 ENOG4108UYU AsnC family transcriptional regulator CGK93_14830 ENOG4105C85 amino acid CGK93_14840 ENOG4105CPP Dehydrogenase, E1 component CGK93_14845 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 CGK93_14865 ENOG4105CSH Transporter CGK93_14870 ENOG4108FUF Transcriptional regulator, IclR family CGK93_14880 ENOG4107R55 ethanolamine transporter CGK93_14895 ENOG4105EYH Exonuclease CGK93_14910 ENOG4105JP4 Inner membrane protein yidG CGK93_14915 ENOG4105VG5 Membrane CGK93_14940 ENOG4105DVE abc transporter atp-binding protein CGK93_14955 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CGK93_14960 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CGK93_14965 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CGK93_14970 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CGK93_14980 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) CGK93_14990 ENOG4108RWI nicotinamidase CGK93_15005 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CGK93_15020 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CGK93_15050 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) CGK93_15055 ENOG4105CE4 GlcNAc 6-P deacetylase CGK93_15065 ENOG4105FF5 Membrane CGK93_15070 ENOG4108SEA Esterase CGK93_15080 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CGK93_15085 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CGK93_15090 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CGK93_15095 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CGK93_15100 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CGK93_15105 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) CGK93_15110 ENOG4106DE0 ATP synthase CGK93_15115 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) CGK93_15135 ENOG4108MKI Glycosyl transferase, family 2 CGK93_15150 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CGK93_15155 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CGK93_15165 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CGK93_15170 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) CGK93_15175 ENOG4105D6E homoserine dehydrogenase CGK93_15180 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CGK93_15185 ENOG4105C75 arginyL-tRNA synthetase CGK93_15200 ENOG4108JA0 Oxidoreductase, FAD NAD(P)-binding domain protein CGK93_15210 ENOG4105D4Y metalloprotease CGK93_15230 ENOG4105CQ7 ATP-dependent helicase CGK93_15235 ENOG4107ZUX Histidine triad (HIT) protein CGK93_15240 ENOG4105DQ4 alcohol dehydrogenase CGK93_15265 ENOG4105CC5 ABC transporter CGK93_15270 ENOG4105DIK (ABC) transporter CGK93_15275 ENOG4105DSE periplasmic solute binding protein CGK93_15285 ENOG4105C37 (CBS) domain CGK93_15290 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CGK93_15320 ENOG4105EMN RNA polymerase sigma factor CGK93_15330 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CGK93_15340 ENOG4107TK4 histidinol-phosphate phosphatase CGK93_15345 ENOG4105C9B Cysteine desulfurase CGK93_15370 ENOG4105C0H protease CGK93_15380 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CGK93_15385 ENOG41061JJ Peptidase family M23 CGK93_15390 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) CGK93_15395 ENOG4105CAK Cell division ATP-binding protein ftsE CGK93_15400 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CGK93_15485 ENOG4105EY8 ABC transporter CGK93_15510 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CGK93_15515 ENOG4105J5G Transferase hexapeptide repeat containing protein CGK93_15540 ENOG4105C7I Dehydrogenase CGK93_15575 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CGK93_15580 ENOG4105T0Z Conserved Protein CGK93_15585 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea CGK93_15595 ENOG4108T3R lipoprotein lpqB CGK93_15600 ENOG4105BZU Histidine kinase CGK93_15620 ENOG4108WQ6 secreted protein CGK93_15625 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CGK93_15655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CGK93_15660 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CGK93_15680 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CGK93_15695 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CGK93_15700 ENOG4105DVC DnaJ domain protein CGK93_15705 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CGK93_15720 ENOG4105C6Z Gluconate CGK93_15725 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CGK93_15730 ENOG4105FJR Lmbe family CGK93_15735 ENOG4105C10 Electron transfer flavoprotein CGK93_15740 ENOG4105BZJ Electron transfer flavoprotein CGK93_15745 ENOG4105C0H protease CGK93_15760 ENOG41087YS Phage shock protein A CGK93_15765 ENOG4105FDP GntR family transcriptional regulator CGK93_15780 ENOG4105DJZ UPF0182 protein CGK93_15805 ENOG4105E09 nadh pyrophosphatase CGK93_15835 ENOG4106TNF Periplasmic binding protein CGK93_15840 ENOG4105EAD ABC transporter CGK93_15845 ENOG4105CDA abc transporter atp-binding protein CGK93_15850 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) CGK93_15855 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CGK93_15865 ENOG4105D52 delta-aminolevulinic acid dehydratase CGK93_15875 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CGK93_15880 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CGK93_15895 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CGK93_15900 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CGK93_15925 ENOG41090A4 Pterin carbinolamine dehydratase CGK93_15930 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CGK93_15940 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CGK93_15945 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CGK93_15955 ENOG4105YB8 TM2 domain containing protein CGK93_15965 ENOG4105C1J atp-dependent rna helicase CGK93_15975 ENOG41081FY multiple antibiotic resistance (MarC)-related CGK93_15995 ENOG4105CJW magnesium transporter CGK93_16010 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) CGK93_16020 ENOG4105DU6 RNA polymerase CGK93_16045 ENOG4108URH decarboxylase CGK93_16050 ENOG4105CDA abc transporter atp-binding protein CGK93_16055 ENOG4107UBR Extracellular solute-binding protein family 3 CGK93_16060 ENOG4105EAD ABC transporter CGK93_16065 ENOG4105DRP amino acid AbC transporter CGK93_16070 ENOG4107R4C succinyl-diaminopimelate desuccinylase CGK93_16075 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) CGK93_16090 ENOG4105W1N transcriptional regulator CGK93_16095 ENOG4105CMR udp-glucose 4-epimerase CGK93_16110 ENOG4108Z4U Ferredoxin CGK93_16125 ENOG4105CI3 gtp-binding protein typa CGK93_16140 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CGK93_16145 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CGK93_16150 ENOG4105DEF Extracellular solute-binding protein, family 5 CGK93_16155 ENOG4105C3G gtp-binding protein CGK93_16165 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CGK93_16175 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CGK93_16180 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CGK93_16185 ENOG4105CSR polyphosphate kinase 2 CGK93_16210 ENOG4108IJ8 ABC transporter CGK93_16215 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CGK93_16230 ENOG4105EUB pirin domain protein CGK93_16235 ENOG4105RD7 BadF BadG BcrA BcrD CGK93_16240 ENOG4105EA8 2-Nitropropane dioxygenase CGK93_16245 ENOG4105C5Q Transcriptional regulator CGK93_16250 ENOG4105D94 Major Facilitator Superfamily CGK93_16280 ENOG4105D7N magnesium and cobalt transport protein CorA CGK93_16290 ENOG4107YEV ferritin CGK93_16295 ENOG41083TI Protein CrcB homolog CGK93_16300 ENOG41085J0 Protein CrcB homolog CGK93_16340 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CGK93_16345 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CGK93_16365 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CGK93_16385 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CGK93_16415 ENOG4105EXC Acyl-transferase CGK93_16425 ENOG4105H3G oxidoreductase CGK93_16440 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CGK93_16445 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CGK93_16460 ENOG4105F9E Shikimate 5-dehydrogenase CGK93_16465 ENOG4108638 50S ribosomal protein L36 CGK93_16475 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) CGK93_16480 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CGK93_16485 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CGK93_16495 ENOG4108097 ATP-binding protein CGK93_16500 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CGK93_16510 ENOG4105F8D glycoside hydrolase family 4 CGK93_16520 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CGK93_16525 ENOG4105CKU formyltetrahydrofolate synthetase CGK93_16535 ENOG4105CPC Aldo Keto reductase CGK93_16560 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CGK93_16565 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CGK93_16580 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CGK93_16585 ENOG4108UJD 30S ribosomal protein S9 CGK93_16590 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CGK93_16640 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CGK93_16645 ENOG4108ZT0 50S ribosomal protein l17 CGK93_16650 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CGK93_16655 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CGK93_16660 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CGK93_16670 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CGK93_16710 ENOG410719E cytochrome p450 CGK93_16715 ENOG4108SHN Glycosyl transferase, family 2 CGK93_16720 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CGK93_16725 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CGK93_16740 ENOG410849U 50S ribosomal protein L30 CGK93_16745 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CGK93_16750 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CGK93_16755 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CGK93_16760 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CGK93_16765 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CGK93_16770 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CGK93_16775 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CGK93_16780 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CGK93_16785 ENOG41082SA 50s ribosomal protein l29 CGK93_16790 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CGK93_16795 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CGK93_16800 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CGK93_16805 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CGK93_16810 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CGK93_16815 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CGK93_16820 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CGK93_16825 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CGK93_16830 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CGK93_16845 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CGK93_16850 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CGK93_16855 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CGK93_16860 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CGK93_16865 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CGK93_16870 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CGK93_16875 ENOG4105CHU acetyl-coa acetyltransferase CGK93_16880 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CGK93_16885 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CGK93_16890 ENOG4108VZM 50s ribosomal protein L10 CGK93_16905 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CGK93_16910 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CGK93_16920 ENOG410683Z Preprotein translocase SecE subunit CGK93_16935 ENOG4105WH1 Two component transcriptional regulator luxr family CGK93_16985 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CGK93_16995 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands CGK93_17005 ENOG4107NHD transcriptional regulator CGK93_17010 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CGK93_17015 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CGK93_17035 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CGK93_17040 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CGK93_17050 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CGK93_17080 ENOG410900P UPF0336 protein CGK93_17110 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component CGK93_17120 ENOG4107QM2 Aldo Keto reductase CGK93_17125 ENOG4105CG3 alpha amylase, catalytic region CGK93_17135 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CGK93_17145 ENOG4105DKQ ROK family CGK93_17170 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein CGK93_17200 ENOG4106032 Glutathionylspermidine synthase CGK93_17205 ENOG4105D5Q Arginine ornithine antiporter CGK93_17210 ENOG4108VJY integral membrane protein CGK93_17225 ENOG4108JP0 extracellular solute-binding protein family 1 CGK93_17260 ENOG4105HSS phospholipase C CGK93_17265 ENOG4108VJY integral membrane protein CGK93_17300 ENOG4105CEY Amp-dependent synthetase and ligase CGK93_17310 ENOG41080RH Thioredoxin CGK93_17315 ENOG4107YB1 Trehalose corynomycolyl transferase CGK93_17320 ENOG4108X07 Tetr family transcriptional regulator CGK93_17325 ENOG4105CIG ABC transporter CGK93_17360 ENOG4108VPT UPF0234 protein CGK93_17365 ENOG4105D0M Protease HtpX homolog CGK93_17385 ENOG4105CH6 catalase CGK93_17395 ENOG4105CUB amino acid CGK93_17410 ENOG4105C26 Dehydrogenase CGK93_17415 ENOG4107RR1 TRANSCRIPTIONal CGK93_17440 ENOG4105C26 Dehydrogenase CGK93_17445 ENOG4105G9B Transcriptional regulator CGK93_17450 ENOG4105DJ2 Major Facilitator Superfamily CGK93_17455 ENOG4105JXH GntR family transcriptional regulator CGK93_17460 ENOG4107TPS domain protein CGK93_17480 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CGK93_17490 ENOG4105CSV Glutaminase CGK93_17505 ENOG4105CXN decarboxylase CGK93_17510 ENOG4108M8W Monooxygenase CGK93_17545 ENOG4105NAE bifunctional deaminase-reductase domain protein CGK93_17560 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CGK93_17565 ENOG4108IY8 ABC, transporter CGK93_17575 ENOG4107QK5 Homocysteine s-methyltransferase CGK93_17595 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CGK93_17605 ENOG4105EN6 Membrane CGK93_17630 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CGK93_17635 ENOG4105E4F Isochorismate synthase CGK93_17640 ENOG4107R0W ABC transporter CGK93_17645 ENOG4105E5Q amino acid AbC transporter CGK93_17660 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CGK93_17670 ENOG4107TCW O-succinylbenzoate synthase CGK93_17685 ENOG4105ETE Transcriptional regulator (LacI family CGK93_17695 ENOG4105DRS transport system, permease CGK93_17700 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CGK93_17755 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CGK93_17765 ENOG41082W1 Cupin 2, conserved barrel domain protein CGK93_17800 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 CGK93_17805 ENOG4105CPP Dehydrogenase, E1 component CGK93_17830 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CGK93_17875 ENOG4105EY8 ABC transporter CGK93_17885 ENOG4105CPK Glycosyl transferase (Group 1 CGK93_17905 ENOG4108KGH TRANSCRIPTIONal CGK93_17930 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CGK93_17940 ENOG4105BZU Histidine kinase CGK93_17970 ENOG4105VMP Transcriptional regulator CGK93_18000 ENOG4105CNG UPF0061 protein CGK93_18010 ENOG4107TE5 Lipid kinase CGK93_18015 ENOG4105CGU Enoyl-CoA hydratase CGK93_18020 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CGK93_18025 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit CGK93_18030 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit CGK93_18035 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit CGK93_18040 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit CGK93_18050 ENOG4108KGH TRANSCRIPTIONal CGK93_18095 ENOG4108IJ6 ABC transporter CGK93_18110 ENOG4107YJ4 chain length determinant protein CGK93_18130 ENOG4105BZU Histidine kinase CGK93_18170 ENOG4105JNK Glycosyl transferase (Group 1 CGK93_18175 ENOG4105CKK Glycosyl transferase, family 2 CGK93_18195 ENOG4105BZU Histidine kinase CGK93_18205 ENOG4105BZU Histidine kinase CGK93_18215 ENOG4108ZJI phenylacetic acid degradation protein CGK93_18220 ENOG4105DZS Phenylacetate-CoA ligase CGK93_18230 ENOG4105DXM phenylacetic acid degradation protein CGK93_18235 ENOG4108RJ9 Glycosyl transferase, family 2 CGK93_18245 ENOG4108VQR secreted hydrolase CGK93_18255 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CGK93_18260 ENOG4105E39 Enoyl-CoA hydratase CGK93_18265 ENOG4105CHU acetyl-coa acetyltransferase CGK93_18285 ENOG4108IQE Amp-dependent synthetase and ligase CGK93_18300 ENOG4105C85 amino acid CGK93_18310 ENOG4108IFG nitrite reductase, (NAD(P)H) CGK93_18340 ENOG4105DIK (ABC) transporter CGK93_18345 ENOG4105DSE periplasmic solute binding protein CGK93_18350 ENOG4108TYN CAAX amino terminal protease family protein CGK93_18360 ENOG4105DRS transport system, permease CGK93_18365 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CGK93_18380 ENOG4107SIQ Naphthoate synthase CGK93_18430 ENOG4105CFG Acts as a chaperone (By similarity) CGK93_18435 ENOG4105CRE cytochrome C CGK93_18440 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) CGK93_18445 ENOG4107QIV Cytochrome c biogenesis protein CGK93_18455 ENOG4108RH7 phosphoglycerate mutase CGK93_18480 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) CGK93_18490 ENOG4108RXW HAD-superfamily subfamily IB hydrolase CGK93_18510 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) CGK93_18515 ENOG4105I82 acetyl xylan esterase CGK93_18525 ENOG4107TDE lipolytic protein G-D-S-L family CGK93_18530 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CGK93_18540 ENOG4105E0S extracellular solute-binding protein family 1 CGK93_18565 ENOG4107Y80 Major Facilitator superfamily CGK93_18575 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CGK93_18580 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CGK93_18600 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CGK93_18605 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CGK93_18615 ENOG4105EPC oxidoreductase CGK93_18630 ENOG4105DIA mandelate racemase muconate lactonizing CGK93_18645 ENOG4105DDC Oxidoreductase domain protein CGK93_18655 ENOG4105G3Z GntR family transcriptional regulator CGK93_18665 ENOG4105D82 Glutamate dehydrogenase CGK93_18670 ENOG41082BM Transcriptional regulator, arsr family CGK93_18675 ENOG4105DGU Histone deacetylase CGK93_18685 ENOG4107ZYR domain protein CGK93_18690 ENOG4105II7 pyrroline-5-carboxylate reductase CGK93_18695 ENOG4105EY0 Xylose isomerase domain protein TIM barrel CGK93_18700 ENOG4107R33 ppx gppa phosphatase CGK93_18710 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CGK93_18735 ENOG4105C72 UPF0176 protein CGK93_18745 ENOG4108I5C dEAD DEAH box helicase CGK93_18785 ENOG4105C2M dna polymerase I CGK93_18850 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CGK93_18855 ENOG4105MVE transcriptional regulator CGK93_18870 ENOG4105ETE Transcriptional regulator (LacI family CGK93_18885 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CGK93_18900 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CGK93_18930 ENOG4105BZ4 penicillin-binding protein CGK93_18935 ENOG4107RGJ metallophosphoesterase CGK93_18940 ENOG4105BZ1 (ABC) transporter CGK93_18945 ENOG4105BZ1 (ABC) transporter CGK93_18965 ENOG4105C8V SAICAR synthetase CGK93_18970 ENOG4105C12 Phosphoribosylglycinamide synthetase CGK93_18985 ENOG4105CK2 sodium dicarboxylate symporter CGK93_18995 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CGK93_19000 ENOG410633P Hydantoin racemase CGK93_19005 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease CGK93_19010 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CGK93_19030 ENOG4105C7W Xanthine dehydrogenase CGK93_19040 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family CGK93_19045 ENOG4105C7N Xanthine uracil vitamin C permease CGK93_19050 ENOG4107Y2X deaminase CGK93_19055 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CGK93_19085 ENOG4105C2W permease CGK93_19095 ENOG41069M3 Transcriptional regulator CGK93_19105 ENOG4107R9S Malate synthase CGK93_19115 ENOG4105S0E allantoin catabolism protein CGK93_19145 ENOG4105BZ4 penicillin-binding protein CGK93_19150 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein CGK93_19165 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CGK93_19170 ENOG4105CSH Transporter CGK93_19175 ENOG4107258 Transcriptional regulator CGK93_19180 ENOG4107RSM transcriptional regulator CGK93_19190 ENOG4105CPQ Dehydrogenase CGK93_19195 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein CGK93_19225 ENOG4105CHH sulfate transporter CGK93_19255 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CGK93_19270 ENOG4105EKC CGK93_19280 ENOG41079KZ Major Facilitator Superfamily CGK93_19290 ENOG4105CD3 dihydroorotase CGK93_19300 ENOG4105CX8 fg-gap repeat protein CGK93_19365 ENOG4105TVB Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CGK93_19370 ENOG4105KVH Transcriptional regulator CGK93_19415 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CGK93_19420 ENOG4105E39 Enoyl-CoA hydratase CGK93_19425 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CGK93_19545 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CGK93_19590 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CGK93_19640 ENOG4105CK5 oxidoreductase CGK93_19655 ENOG4107T3P ABC, transporter CGK93_19660 ENOG4105ETE Transcriptional regulator (LacI family CGK93_19695 ENOG41084S7 Plasmid maintenance system antidote protein CGK93_19720 ENOG4107TFQ Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) CGK93_19725 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CGK93_19730 ENOG41060W2 glyoxylate carboligase CGK93_19735 ENOG4105BZW Glycerate kinase CGK93_19745 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CGK93_19755 ENOG4108PYU two-component system response regulator CGK93_19760 ENOG4107QZ7 Cellulose synthase catalytic subunit CGK93_19765 ENOG4105WN5 stage II sporulation protein CGK93_19805 ENOG410841Q phosphoesterase PA-phosphatase related protein CGK93_19830 ENOG4105CXB phosphoribosylaminoimidazole synthetase CGK93_19855 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CGK93_19900 ENOG410901E Membrane CGK93_19910 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase CGK93_19915 ENOG41090B9 response to stress CGK93_19920 ENOG4105KPY Small multidrug resistance protein CGK93_19925 ENOG4105KPY Small multidrug resistance protein CGK93_19930 ENOG4105CPC Aldo Keto reductase CGK93_19940 ENOG4105C1J atp-dependent rna helicase CGK93_19950 ENOG4108Z4X TRANSCRIPTIONal CGK93_19970 ENOG4105CH2 amidohydrolase CGK93_19975 ENOG4105CSH Transporter CGK93_19980 ENOG4105DJ2 Major Facilitator Superfamily CGK93_19985 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) CGK93_19990 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CGK93_20030 ENOG4105C0D helicase CGK93_20040 ENOG4105FDP GntR family transcriptional regulator CGK93_20060 ENOG41060NJ transcriptional regulator CGK93_20070 ENOG4105C5I Dehydrogenase CGK93_20075 ENOG4105BZ7 extracellular solute-binding protein family 1 CGK93_20080 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CGK93_20085 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CGK93_20105 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CGK93_20110 ENOG4105DWY Agmatine deiminase CGK93_20140 ENOG4105KNI merR family transcriptional Regulator CGK93_20145 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CGK93_20150 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CGK93_20155 ENOG4105CFG Acts as a chaperone (By similarity) CGK93_20160 ENOG4105NX3 Membrane CGK93_20200 ENOG4105C5I Dehydrogenase CGK93_20215 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CGK93_20220 ENOG4105DRS transport system, permease CGK93_20230 ENOG4105DKQ ROK family CGK93_20265 ENOG4105WEM extracellular solute-binding protein CGK93_20280 ENOG4105C5I Dehydrogenase CGK93_20295 ENOG4105DGI Alkaline phosphatase CGK93_20335 ENOG4105W1N transcriptional regulator CGK93_20340 ENOG410829K Lysine exporter protein (Lyse ygga) CGK93_20380 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) CGK93_20385 ENOG4105GRZ Ycii-related protein CGK93_20390 ENOG4105CHP RNA polymerase CGK93_20395 ENOG4105CPC Aldo Keto reductase CGK93_20415 ENOG4105ETE Transcriptional regulator (LacI family CGK93_20420 ENOG4105DU0 nucleoside hydrolase CGK93_20425 ENOG41080V3 Major Facilitator superfamily CGK93_20430 ENOG4108RVA ribokinase CGK93_20445 ENOG4105KJF protein tyrosine phosphatase CGK93_20455 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CGK93_20465 ENOG4108IQI permease CGK93_20470 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CGK93_20480 ENOG4105C84 Histidine ammonia-lyase CGK93_20515 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) CGK93_20520 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CGK93_20555 ENOG4108JJB ABC transporter CGK93_20560 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein CGK93_20575 ENOG4105KJM monovalent cation h antiporter subunit g CGK93_20580 ENOG41080TA Multiple resistance and ph regulation protein f CGK93_20590 ENOG4108JPZ Monovalent cation H antiporter subunit D CGK93_20595 ENOG4105MKQ Monovalent cation H antiporter subunit C CGK93_20600 ENOG4105D65 subunit l CGK93_20615 ENOG4107S91 Sodium hydrogen exchanger CGK93_20625 ENOG4105DHP deoxycytidine triphosphate deaminase CGK93_20655 ENOG4105DCF alanine dehydrogenase CGK93_20665 ENOG4106NZI LysR family Transcriptional regulator CGK93_20685 ENOG4105ETE Transcriptional regulator (LacI family CGK93_20710 ENOG4107S2Z UPF0761 membrane protein CGK93_20735 ENOG4105C93 Xylose Isomerase CGK93_20745 ENOG4105ETE Transcriptional regulator (LacI family CGK93_20750 ENOG4105EF1 ribulokinase CGK93_20760 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) CGK93_20765 ENOG4107WI4 Aldose-1-epimerase CGK93_20775 ENOG4105ETE Transcriptional regulator (LacI family CGK93_20795 ENOG4105DET Rhamnulokinase CGK93_20800 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CGK93_20835 ENOG4105BZP glycoside hydrolase 15-related CGK93_20840 ENOG4105DEN Luciferase family CGK93_20845 ENOG4106PMH Extracellular solute-binding protein family 3 CGK93_20850 ENOG4105C7B Threonine dehydratase CGK93_20870 ENOG4105CPU Monooxygenase CGK93_20880 ENOG4105DEN Luciferase family CGK93_20890 ENOG4105CDA abc transporter atp-binding protein CGK93_20895 ENOG4105E5Q amino acid AbC transporter CGK93_20910 ENOG4105D7A ATP-binding protein CGK93_20925 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein CGK93_20930 ENOG4108426 dNA-binding protein CGK93_20985 ENOG41080FR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CGK93_20990 ENOG4105W0E 50S ribosomal protein L33 CGK93_20995 ENOG4105KDC 50s ribosomal protein l28 CGK93_21030 ENOG4105E0A ABC, transporter CGK93_21035 ENOG4108IHU transport system permease protein CGK93_21040 ENOG4105DQ5 transport system permease protein CGK93_21080 ENOG4105K5B UPF0225 protein CGK93_21095 ENOG4105CPC Aldo Keto reductase CGK93_21135 ENOG4105JXH GntR family transcriptional regulator CGK93_21145 ENOG4108IJ0 Aspartate ammonia-lyase CGK93_21155 ENOG4107YCY Transcriptional regulator CGK93_21170 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) CGK93_21180 ENOG4105DIA mandelate racemase muconate lactonizing CGK93_21190 ENOG4108R85 Short chain dehydrogenase CGK93_21195 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CGK93_21205 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CGK93_21210 ENOG4105EMU Dehydrogenase CGK93_21225 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) CGK93_21250 ENOG4105MHT Transcriptional regulator, ARSR family CGK93_21265 ENOG4105WH1 Two component transcriptional regulator luxr family CGK93_21270 ENOG4108XG2 Histidine kinase CGK93_21280 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CGK93_21305 ENOG4105EJQ L-serine dehydratase CGK93_21320 ENOG4105C6K Malic enzyme CGK93_21325 ENOG4108SGK Tetr family transcriptional regulator CGK93_21365 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) CGK93_21370 ENOG4105C0R drug resistance transporter emrb qaca subfamily CGK93_21375 ENOG4105C84 Histidine ammonia-lyase CGK93_21380 ENOG4105CGP Urocanate hydratase CGK93_21390 ENOG4105E90 ABC transporter CGK93_21400 ENOG4108IJ8 ABC transporter CGK93_21425 ENOG4105DXB Major Facilitator superfamily CGK93_21470 ENOG4108IPW abc transporter atp-binding protein CGK93_21475 ENOG4105CM4 permease protein CGK93_21480 ENOG4105DHS permease protein CGK93_21490 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase CGK93_21495 ENOG4105CTS PTS system mannitol-specific CGK93_21505 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CGK93_21510 ENOG4105KRI phosphocarrier protein (HPr CGK93_21555 ENOG4105DCF alanine dehydrogenase CGK93_21570 ENOG4105D9R oxidoreductase CGK93_21580 ENOG410684T prevent-host-death family CGK93_21605 ENOG4108SGK Tetr family transcriptional regulator CGK93_21640 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CGK93_21655 ENOG4105CUB amino acid CGK93_21670 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 CGK93_21675 ENOG4105CPP Dehydrogenase, E1 component CGK93_21685 ENOG4105CIH Imidazole acetol-phosphate transaminase CGK93_21690 ENOG41082T9 Membrane CGK93_21705 ENOG4107QTF adenylosuccinate lyase CGK93_21720 ENOG4105NAU thioesterase Superfamily protein CGK93_21755 ENOG4105DRR Transcriptional regulator, GntR family CGK93_21760 ENOG4105ERH Fumarylacetoacetate hydrolase CGK93_21780 ENOG4105Y3U Transglycosylase-associated protein CGK93_21790 ENOG41086D8 Transcriptional regulator CGK93_21795 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CGK93_21800 ENOG4108TM9 integral membrane protein CGK93_21815 ENOG4105VBF alkaline shock protein CGK93_21860 ENOG4105ETE Transcriptional regulator (LacI family CGK93_21875 ENOG4105DRS transport system, permease CGK93_21880 ENOG4108JQ1 Dehydrogenase CGK93_21925 ENOG4105ETS cytosine purines uracil thiamine allantoin CGK93_21965 ENOG4105CHR reductase CGK93_21980 ENOG4105JSC dimethylmenaquinone methyltransferase CGK93_21995 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CGK93_22025 ENOG4105ETE Transcriptional regulator (LacI family CGK93_22030 ENOG4108RVA ribokinase CGK93_22035 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CGK93_22040 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CGK93_22065 ENOG4108M21 CGK93_22095 ENOG4105C3M thioredoxin reductase CGK93_22135 ENOG4108UHU Aldolase CGK93_22140 ENOG4105DKQ ROK family CGK93_22145 ENOG4105FDP GntR family transcriptional regulator CGK93_22155 ENOG4108HWW ABC transporter CGK93_22160 ENOG4105DFW ABC transporter CGK93_22165 ENOG4108BAS reductase CGK93_22175 ENOG4107YCY Transcriptional regulator CGK93_22180 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CGK93_22195 ENOG4107VPB domain protein CGK93_22220 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CGK93_22230 ENOG4105ETE Transcriptional regulator (LacI family CGK93_22245 ENOG4105C5I Dehydrogenase CGK93_22295 ENOG4108JCI Transcriptional regulator CGK93_22305 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family CGK93_22315 ENOG4105BZP glycoside hydrolase 15-related CGK93_22325 ENOG4105T2N Domain of unknown function (DUF2382) CGK93_22330 ENOG4105CSH Transporter CGK93_22335 ENOG4108JQ1 Dehydrogenase CGK93_22340 ENOG4105CPQ Dehydrogenase CGK93_22345 ENOG4105CHR reductase CGK93_22350 ENOG4108UHU Aldolase CGK93_22360 ENOG4107HP6 Transcriptional regulator CGK93_22380 ENOG41069M3 Transcriptional regulator CGK93_22385 ENOG4105D2S major facilitator superfamily CGK93_22420 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CGK93_22430 ENOG41061ZR Transcriptional regulator CGK93_22435 ENOG4107QWE )-transporter CGK93_22440 ENOG4105C0R drug resistance transporter emrb qaca subfamily CGK93_22445 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CGK93_22450 ENOG4105Y3U Transglycosylase-associated protein CGK93_22455 ENOG4107TPY serine threonine protein kinase CGK93_22495 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CGK93_22500 ENOG4105EJQ L-serine dehydratase CGK93_22505 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CGK93_22515 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CGK93_22520 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CGK93_22525 ENOG41080FJ Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CGK93_22540 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CGK93_22545 ENOG4105W8H transhydrogenase (subunit alpha CGK93_22550 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) CGK93_22575 ENOG4108JQ1 Dehydrogenase CGK93_22605 ENOG4105D2S major facilitator superfamily CGK93_22630 ENOG4105ERH Fumarylacetoacetate hydrolase CGK93_22635 ENOG4105KME endoribonuclease L-psp CGK93_22645 ENOG4107HP6 Transcriptional regulator CGK93_22650 ENOG4107QNJ CoA-transferase subunit B CGK93_22660 ENOG4105CHU acetyl-coa acetyltransferase CGK93_22665 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase CGK93_22675 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase CGK93_22695 ENOG4107S9B Shikimate dehydrogenase CGK93_22700 ENOG4105J4Q Transcriptional regulator CGK93_22705 ENOG4105CSH Transporter CGK93_22730 ENOG4105BZU Histidine kinase CGK93_22775 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) CGK93_22800 ENOG4105CG3 alpha amylase, catalytic region CGK93_22815 ENOG4105CSR polyphosphate kinase 2 CGK93_22835 ENOG4106KNT transcriptional regulator CGK93_22840 ENOG4105EHZ conserved protein UCP016719 CGK93_22845 ENOG4105D17 glycoside hydrolase, family 3 domain protein CGK93_22885 ENOG4105VPX protein, conserved in bacteria CGK93_22940 ENOG4107QI1 Mate efflux family protein CGK93_22955 ENOG4105NQG DoxX CGK93_22985 ENOG4105ETX regulatoR CGK93_22990 ENOG41062D9 Histidine kinase CGK93_23005 ENOG4105CDU Replicative dna helicase CGK93_23030 ENOG4108UZX fmn reductase CGK93_23050 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CGK93_23055 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CGK93_23095 ENOG4107258 Transcriptional regulator CGK93_23120 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CGK93_23125 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CGK93_23135 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) CGK93_23140 ENOG4105KK4 UPF0060 membrane protein CGK93_23155 ENOG4105C85 amino acid CGK93_23160 ENOG4105DFM M18 family aminopeptidase CGK93_23180 ENOG4106P37 HTH-type transcriptional regulator YjhI CGK93_23195 ENOG4108IQI permease CGK93_23200 ENOG4105EW9 transcriptional regulator AsnC family CGK93_23205 ENOG4105WH1 Two component transcriptional regulator luxr family CGK93_23210 ENOG4105BZU Histidine kinase CGK93_23220 ENOG4105CJ1 ABC, transporter CGK93_23235 ENOG4106UW1 Major Facilitator superfamily CGK93_23240 ENOG4105E98 transcriptional regulator DeoR family CGK93_23255 ENOG4105CJN penicillin-binding protein CGK93_23265 ENOG4105WH1 Two component transcriptional regulator luxr family CGK93_23270 ENOG4108ZGX Histidine kinase CGK93_23280 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CGK93_23285 ENOG4105KVH Transcriptional regulator CGK93_23290 ENOG4108RYK Nad-dependent epimerase dehydratase CGK93_23305 ENOG4108ZM9 phosphoglycerate mutase CGK93_23310 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CGK93_23330 ENOG4105C3M thioredoxin reductase CGK93_23335 ENOG4105K63 Thioredoxin CGK93_23350 ENOG4107QJE Chromosome Partitioning Protein CGK93_23355 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CGK93_23365 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CGK93_23370 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity)