locus-tag	class	description
N2K99_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N2K99_00015	COG0592	DNA-directed DNA polymerase activity
N2K99_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N2K99_00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
N2K99_00030	COG0187	DNA topoisomerase II activity
N2K99_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N2K99_00040	COG3266	domain, Protein
N2K99_00075	COG0705	Rhomboid family
N2K99_00085	COG3764	Sortase (surface protein transpeptidase)
N2K99_00100	COG0515	serine threonine protein kinase
N2K99_00100	COG2815	serine threonine protein kinase
N2K99_00105	COG0515	serine threonine protein kinase
N2K99_00110	COG0768	penicillin binding
N2K99_00125	COG1716	ATPase activity
N2K99_00130	COG1716	ATPase activity
N2K99_00150	COG0346	lactoylglutathione lyase activity
N2K99_00155	COG0025	NhaP-type Na H and K H
N2K99_00165	COG3265	gluconokinase activity
N2K99_00170	COG2186	Transcriptional regulator
N2K99_00175	COG0783	Belongs to the Dps family
N2K99_00185	COG0723	plastoquinol--plastocyanin reductase activity
N2K99_00190	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_00210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
N2K99_00245	COG1376	ErfK ybiS ycfS ynhG family protein
N2K99_00250	COG0702	epimerase
N2K99_00275	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_00280	COG1609	Transcriptional regulator
N2K99_00300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N2K99_00310	COG0561	phosphatase activity
N2K99_00315	COG0671	phosphoesterase, PA-phosphatase related
N2K99_00320	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N2K99_00325	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
N2K99_00335	COG1929	Belongs to the glycerate kinase type-1 family
N2K99_00340	COG2233	PERMEase
N2K99_00350	COG1012	belongs to the aldehyde dehydrogenase family
N2K99_00370	COG3104	oligopeptide transport
N2K99_00375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N2K99_00385	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N2K99_00405	COG1597	lipid kinase activity
N2K99_00410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N2K99_00415	COG0561	phosphatase activity
N2K99_00430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N2K99_00435	COG2027	D-alanyl-D-alanine carboxypeptidase
N2K99_00445	COG0037	tRNA processing
N2K99_00455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N2K99_00460	COG0302	gtp cyclohydrolase
N2K99_00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N2K99_00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N2K99_00500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N2K99_00505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N2K99_00525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N2K99_00530	COG3237	CsbD-like
N2K99_00535	COG2376	Dihydroxyacetone kinase
N2K99_00540	COG1461	Dihydroxyacetone kinase
N2K99_00560	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
N2K99_00575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N2K99_00585	COG0581	inorganic phosphate transmembrane transporter activity
N2K99_00590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N2K99_00595	COG0306	phosphate transporter
N2K99_00645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2K99_00650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N2K99_00680	COG2733	membrane
N2K99_00685	COG3387	PFAM Glycoside hydrolase 15-related
N2K99_00700	COG2814	Major facilitator Superfamily
N2K99_00715	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N2K99_00720	COG0857	belongs to the CobB CobQ family
N2K99_00720	COG0280	phosphate acetyltransferase
N2K99_00725	COG0531	amino acid
N2K99_00735	COG4122	O-methyltransferase activity
N2K99_00755	COG2252	PERMEase
N2K99_00800	COG1302	Protein conserved in bacteria
N2K99_00840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N2K99_00860	COG0357	Ribosomal RNA small subunit methyltransferase G
N2K99_00860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N2K99_00865	COG0191	fructose-bisphosphate aldolase activity
N2K99_00900	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N2K99_00920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N2K99_00935	COG1832	CoA-binding protein
N2K99_00950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N2K99_00955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2K99_00965	COG1116	anion transmembrane transporter activity
N2K99_00975	COG1832	CoA-binding protein
N2K99_00985	COG2315	Protein conserved in bacteria
N2K99_01005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N2K99_01010	COG0047	phosphoribosylformylglycinamidine synthase activity
N2K99_01070	COG4555	ABC transporter
N2K99_01080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N2K99_01095	COG0363	glucosamine-6-phosphate deaminase activity
N2K99_01120	COG3548	integral membrane protein
N2K99_01145	COG2197	response regulator
N2K99_01155	COG0318	PFAM AMP-dependent synthetase and ligase
N2K99_01160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N2K99_01175	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N2K99_01175	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N2K99_01195	COG0477	Major facilitator Superfamily
N2K99_01250	COG0028	Belongs to the TPP enzyme family
N2K99_01320	COG2072	flavoprotein involved in K transport
N2K99_01330	COG0384	phenazine biosynthesis protein PhzF
N2K99_01355	COG0667	Aldo Keto reductase
N2K99_01380	COG3321	synthase
N2K99_01380	COG0604	alcohol dehydrogenase
N2K99_01380	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_01395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N2K99_01405	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
N2K99_01415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N2K99_01420	COG4608	Belongs to the ABC transporter superfamily
N2K99_01425	COG0444	Belongs to the ABC transporter superfamily
N2K99_01430	COG0601	transmembrane transport
N2K99_01435	COG0747	negative chemotaxis
N2K99_01445	COG0363	glucosamine-6-phosphate deaminase activity
N2K99_01450	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N2K99_01460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N2K99_01465	COG0542	response to heat
N2K99_01485	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_01495	COG1309	transcriptional regulator
N2K99_01515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N2K99_01530	COG0386	Belongs to the glutathione peroxidase family
N2K99_01565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N2K99_01595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N2K99_01600	COG2224	Isocitrate lyase
N2K99_01605	COG1396	sequence-specific DNA binding
N2K99_01615	COG1595	DNA-templated transcription, initiation
N2K99_01620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N2K99_01630	COG1216	Glycosyl transferase, family 2
N2K99_01640	COG0351	phosphomethylpyrimidine kinase
N2K99_01645	COG1309	transcriptional regulator
N2K99_01660	COG0343	queuine tRNA-ribosyltransferase activity
N2K99_01700	COG1960	acyl-CoA dehydrogenase activity
N2K99_01715	COG3486	L-lysine 6-monooxygenase (NADPH) activity
N2K99_01720	COG0076	glutamate decarboxylase activity
N2K99_01735	COG0564	pseudouridine synthase activity
N2K99_01740	COG0659	secondary active sulfate transmembrane transporter activity
N2K99_01745	COG0515	serine threonine protein kinase
N2K99_01750	COG1846	Transcriptional regulator
N2K99_01760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2K99_01765	COG1120	ATPase activity
N2K99_01785	COG0583	DNA-binding transcription factor activity
N2K99_01790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N2K99_01795	COG1201	RNA secondary structure unwinding
N2K99_01815	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N2K99_01820	COG1752	Esterase of the alpha-beta hydrolase superfamily
N2K99_01850	COG4589	Belongs to the CDS family
N2K99_01870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N2K99_01880	COG2062	phosphohistidine phosphatase, SixA
N2K99_01885	COG1511	domain protein
N2K99_01930	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
N2K99_01945	COG0514	ATP-dependent DNA helicase (RecQ)
N2K99_01950	COG2267	carboxylic ester hydrolase activity
N2K99_01960	COG1024	Enoyl-CoA hydratase
N2K99_01970	COG0667	Aldo Keto reductase
N2K99_01985	COG1505	serine-type exopeptidase activity
N2K99_02030	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N2K99_02045	COG2072	flavoprotein involved in K transport
N2K99_02060	COG0604	alcohol dehydrogenase
N2K99_02065	COG1966	Carbon starvation protein
N2K99_02085	COG0656	L-ascorbic acid biosynthetic process
N2K99_02115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N2K99_02135	COG1815	bacterial-type flagellum-dependent cell motility
N2K99_02140	COG1558	bacterial-type flagellum-dependent cell motility
N2K99_02145	COG1677	Flagellar hook-basal body complex protein FliE
N2K99_02150	COG1766	The M ring may be actively involved in energy transduction
N2K99_02155	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N2K99_02165	COG1157	protein secretion by the type III secretion system
N2K99_02185	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
N2K99_02200	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N2K99_02205	COG1360	Flagellar Motor Protein
N2K99_02225	COG1338	Plays a role in the flagellum-specific transport system
N2K99_02230	COG1987	bacterial-type flagellum assembly
N2K99_02240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N2K99_02245	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N2K99_02255	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N2K99_02275	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N2K99_02280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N2K99_02285	COG0626	cystathionine gamma-synthase activity
N2K99_02300	COG0588	phosphoglycerate mutase activity
N2K99_02310	COG5002	protein histidine kinase activity
N2K99_02315	COG0745	RESPONSE REGULATOR receiver
N2K99_02330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N2K99_02335	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N2K99_02340	COG0215	cysteine-tRNA ligase activity
N2K99_02345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N2K99_02360	COG0366	Alpha amylase catalytic
N2K99_02370	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N2K99_02420	COG0277	FAD linked oxidase domain protein
N2K99_02425	COG0366	Alpha amylase catalytic
N2K99_02440	COG3842	ATPase activity
N2K99_02485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N2K99_02490	COG0477	Major facilitator Superfamily
N2K99_02495	COG0477	Major facilitator Superfamily
N2K99_02500	COG1957	nucleoside hydrolase
N2K99_02520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2K99_02525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2K99_02555	COG2159	amidohydrolase
N2K99_02600	COG2807	transmembrane transport
N2K99_02610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N2K99_02610	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N2K99_02655	COG0667	Aldo Keto reductase
N2K99_02685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N2K99_02705	COG0459	protein refolding
N2K99_02715	COG2205	protein histidine kinase activity
N2K99_02720	COG0745	RESPONSE REGULATOR receiver
N2K99_02765	COG1278	Cold shock
N2K99_02790	COG0739	heme binding
N2K99_02820	COG0303	'Molybdopterin
N2K99_02825	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N2K99_02830	COG5002	protein histidine kinase activity
N2K99_02835	COG1132	(ABC) transporter
N2K99_02855	COG1940	carbohydrate kinase activity
N2K99_02860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N2K99_02900	COG0483	inositol monophosphate 1-phosphatase activity
N2K99_02910	COG0045	succinate-CoA ligase (ADP-forming) activity
N2K99_02920	COG2814	Major facilitator Superfamily
N2K99_02930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N2K99_02960	COG0318	PFAM AMP-dependent synthetase and ligase
N2K99_02975	COG1396	sequence-specific DNA binding
N2K99_02990	COG0028	Belongs to the TPP enzyme family
N2K99_03100	COG0596	Alpha beta hydrolase
N2K99_03110	COG1404	Belongs to the peptidase S8 family
N2K99_03120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N2K99_03150	COG0640	Transcriptional regulator
N2K99_03160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N2K99_03165	COG1914	H( )-stimulated, divalent metal cation uptake system
N2K99_03170	COG1914	H( )-stimulated, divalent metal cation uptake system
N2K99_03175	COG4336	lyase activity
N2K99_03185	COG4770	biotin carboxylase activity
N2K99_03190	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
N2K99_03195	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N2K99_03220	COG0277	FAD linked oxidase domain protein
N2K99_03255	COG4213	ABC transporter substrate-binding protein
N2K99_03260	COG1129	ABC transporter
N2K99_03265	COG4214	carbohydrate transport
N2K99_03275	COG0673	inositol 2-dehydrogenase activity
N2K99_03280	COG1879	ABC-type sugar transport system periplasmic component
N2K99_03285	COG1129	ABC transporter
N2K99_03290	COG1172	Belongs to the binding-protein-dependent transport system permease family
N2K99_03295	COG1940	carbohydrate kinase activity
N2K99_03300	COG0583	DNA-binding transcription factor activity
N2K99_03320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2K99_03340	COG1397	ADP-ribosylglycohydrolase
N2K99_03360	COG1074	ATP-dependent DNA helicase activity
N2K99_03390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N2K99_03410	COG2235	arginine
N2K99_03435	COG2271	Major facilitator Superfamily
N2K99_03440	COG0154	amidase activity
N2K99_03505	COG1960	acyl-CoA dehydrogenase activity
N2K99_03510	COG0183	Belongs to the thiolase family
N2K99_03540	COG1358	cellular component organization or biogenesis
N2K99_03630	COG1024	Enoyl-CoA hydratase
N2K99_03635	COG1250	3-hydroxyacyl-CoA dehydrogenase
N2K99_03655	COG2115	Belongs to the xylose isomerase family
N2K99_03660	COG1070	Carbohydrate kinase
N2K99_03665	COG2017	converts alpha-aldose to the beta-anomer
N2K99_03680	COG3458	cephalosporin-C deacetylase activity
N2K99_03685	COG1472	Belongs to the glycosyl hydrolase 3 family
N2K99_03700	COG1653	transport
N2K99_03705	COG1609	Transcriptional regulator
N2K99_03730	COG1802	Transcriptional regulator
N2K99_03735	COG1053	succinate dehydrogenase
N2K99_03755	COG2390	Transcriptional regulator
N2K99_03760	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N2K99_03775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N2K99_03790	COG2814	Major facilitator Superfamily
N2K99_03795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N2K99_03805	COG0667	Aldo Keto reductase
N2K99_03815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N2K99_03835	COG0247	lactate metabolic process
N2K99_03840	COG1139	Iron-sulfur cluster binding protein
N2K99_03845	COG1556	Lactate utilization protein
N2K99_03855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N2K99_03865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N2K99_03870	COG1620	l-lactate permease
N2K99_03875	COG3619	membrane
N2K99_03885	COG0039	L-malate dehydrogenase activity
N2K99_03890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N2K99_03900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N2K99_03910	COG2323	membrane
N2K99_03915	COG2304	oxidoreductase activity
N2K99_03920	COG1278	Cold shock
N2K99_03925	COG2066	Belongs to the glutaminase family
N2K99_03925	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
N2K99_03930	COG1278	Cold shock
N2K99_03940	COG0515	serine threonine protein kinase
N2K99_03945	COG3012	SEC-C Motif Domain Protein
N2K99_03950	COG1063	alcohol dehydrogenase
N2K99_03970	COG0829	nickel cation binding
N2K99_03975	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N2K99_03985	COG0804	urea catabolic process
N2K99_03995	COG0831	urea catabolic process
N2K99_04020	COG0753	catalase activity
N2K99_04080	COG0477	Major facilitator Superfamily
N2K99_04095	COG0385	Bile acid
N2K99_04145	COG4214	carbohydrate transport
N2K99_04150	COG1129	ABC transporter
N2K99_04180	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N2K99_04185	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N2K99_04215	COG0708	Exodeoxyribonuclease III
N2K99_04220	COG0180	Tryptophanyl-tRNA synthetase
N2K99_04235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N2K99_04250	COG2009	succinate dehydrogenase
N2K99_04260	COG1473	amidohydrolase
N2K99_04260	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N2K99_04265	COG1744	ABC transporter substrate-binding protein PnrA-like
N2K99_04270	COG3845	ABC transporter
N2K99_04275	COG4603	Belongs to the binding-protein-dependent transport system permease family
N2K99_04280	COG1079	Belongs to the binding-protein-dependent transport system permease family
N2K99_04300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N2K99_04305	COG3956	TIGRFAM MazG family protein
N2K99_04310	COG0148	phosphopyruvate hydratase activity
N2K99_04335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N2K99_04370	COG0559	Belongs to the binding-protein-dependent transport system permease family
N2K99_04385	COG2017	converts alpha-aldose to the beta-anomer
N2K99_04395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N2K99_04400	COG0705	Rhomboid family
N2K99_04405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N2K99_04415	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N2K99_04425	COG1331	Highly conserved protein containing a thioredoxin domain
N2K99_04435	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N2K99_04440	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N2K99_04455	COG0477	Major facilitator Superfamily
N2K99_04465	COG0114	fumarate hydratase activity
N2K99_04480	COG1494	fructose-1,6-bisphosphatase
N2K99_04495	COG0477	Major facilitator Superfamily
N2K99_04505	COG4569	acetaldehyde dehydrogenase (acetylating) activity
N2K99_04510	COG1414	Transcriptional regulator
N2K99_04520	COG1316	TRANSCRIPTIONal
N2K99_04575	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N2K99_04625	COG0714	Associated with various cellular activities
N2K99_04630	COG0084	hydrolase, TatD family'
N2K99_04650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N2K99_04655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N2K99_04660	COG0488	(ABC) transporter
N2K99_04680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N2K99_04685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N2K99_04690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N2K99_04695	COG0193	aminoacyl-tRNA hydrolase activity
N2K99_04730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N2K99_04735	COG0110	maltose O-acetyltransferase activity
N2K99_04765	COG0489	protein tyrosine kinase activity
N2K99_04800	COG0822	iron-sulfur transferase activity
N2K99_04815	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N2K99_04820	COG0297	glycogen (starch) synthase activity
N2K99_04825	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
N2K99_04830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N2K99_04835	COG5002	protein histidine kinase activity
N2K99_04845	COG5002	protein histidine kinase activity
N2K99_04890	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N2K99_04930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N2K99_04960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N2K99_04975	COG0477	Major facilitator Superfamily
N2K99_04980	COG4770	biotin carboxylase activity
N2K99_04990	COG0424	maF-like protein
N2K99_04995	COG1823	symporter activity
N2K99_05010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N2K99_05040	COG0714	Associated with various cellular activities
N2K99_05055	COG0631	protein serine/threonine phosphatase activity
N2K99_05080	COG1674	ftsk spoiiie
N2K99_05130	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N2K99_05135	COG0483	inositol monophosphate 1-phosphatase activity
N2K99_05160	COG0456	acetyltransferase
N2K99_05165	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N2K99_05170	COG0154	amidase activity
N2K99_05175	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N2K99_05200	COG1254	Belongs to the acylphosphatase family
N2K99_05205	COG2986	histidine ammonia-lyase
N2K99_05210	COG1414	Transcriptional regulator
N2K99_05215	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N2K99_05230	COG1228	amidohydrolase
N2K99_05245	COG3250	beta-galactosidase activity
N2K99_05260	COG2873	o-acetylhomoserine
N2K99_05265	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N2K99_05300	COG0423	glycine-tRNA ligase activity
N2K99_05315	COG2031	fatty acid transporter
N2K99_05335	COG0358	DNA primase activity
N2K99_05360	COG0477	Major facilitator Superfamily
N2K99_05380	COG0297	glycogen (starch) synthase activity
N2K99_05390	COG1960	acyl-CoA dehydrogenase activity
N2K99_05400	COG0052	Belongs to the universal ribosomal protein uS2 family
N2K99_05405	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N2K99_05410	COG0528	UMP kinase activity
N2K99_05415	COG0233	cytoplasmic translational termination
N2K99_05420	COG0575	Belongs to the CDS family
N2K99_05430	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N2K99_05445	COG3275	phosphorelay sensor kinase activity
N2K99_05455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N2K99_05470	COG0022	dehydrogenase e1 component
N2K99_05475	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2K99_05485	COG1309	transcriptional regulator
N2K99_05490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N2K99_05500	COG1960	acyl-CoA dehydrogenase activity
N2K99_05530	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N2K99_05535	COG0750	zinc metalloprotease
N2K99_05555	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N2K99_05575	COG0442	prolyl-tRNA aminoacylation
N2K99_05595	COG0779	Required for maturation of 30S ribosomal subunits
N2K99_05610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N2K99_05615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N2K99_05620	COG0436	Aminotransferase
N2K99_05625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N2K99_05650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N2K99_05655	COG1185	polyribonucleotide nucleotidyltransferase activity
N2K99_05660	COG0612	Peptidase, M16
N2K99_05700	COG0521	Mo-molybdopterin cofactor biosynthetic process
N2K99_05710	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N2K99_05725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N2K99_05730	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N2K99_05735	COG1674	ftsk spoiiie
N2K99_05745	COG1058	Belongs to the CinA family
N2K99_05745	COG1546	Belongs to the CinA family
N2K99_05750	COG1396	sequence-specific DNA binding
N2K99_05765	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N2K99_05770	COG2137	regulation of response to DNA damage stimulus
N2K99_05785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N2K99_05790	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N2K99_05795	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N2K99_05800	COG2813	Specifically methylates the guanine in position
N2K99_05805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N2K99_05815	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N2K99_05825	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N2K99_05830	COG0131	Imidazoleglycerol-phosphate dehydratase
N2K99_05835	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N2K99_05845	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N2K99_05865	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N2K99_05870	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N2K99_05875	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N2K99_05880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N2K99_05890	COG2814	Major facilitator Superfamily
N2K99_05895	COG0494	nUDIX hydrolase
N2K99_05910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N2K99_05915	COG0072	phenylalanine-tRNA ligase activity
N2K99_05915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N2K99_05920	COG1011	Hydrolase
N2K99_05930	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N2K99_05935	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N2K99_05940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N2K99_05945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N2K99_05950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N2K99_05955	COG1438	arginine binding
N2K99_05960	COG0137	argininosuccinate synthase activity
N2K99_05965	COG0165	Argininosuccinate lyase
N2K99_05970	COG0259	pyridoxamine-phosphate oxidase activity
N2K99_05985	COG2094	Belongs to the DNA glycosylase MPG family
N2K99_05995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N2K99_06005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N2K99_06030	COG0647	UMP catabolic process
N2K99_06045	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N2K99_06050	COG0497	DNA recombination
N2K99_06055	COG0504	CTP synthase activity
N2K99_06060	COG0494	nUDIX hydrolase
N2K99_06070	COG1051	belongs to the nudix hydrolase family
N2K99_06080	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N2K99_06085	COG2079	MmgE PrpD family protein
N2K99_06100	COG4565	transcriptional regulatory protein
N2K99_06105	COG3290	protein histidine kinase activity
N2K99_06110	COG1301	dicarboxylic acid transport
N2K99_06125	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N2K99_06130	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N2K99_06140	COG0287	Prephenate dehydrogenase
N2K99_06145	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N2K99_06150	COG1160	GTP binding
N2K99_06170	COG2197	response regulator
N2K99_06180	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_06185	COG2133	pyrroloquinoline quinone binding
N2K99_06195	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N2K99_06220	COG1716	ATPase activity
N2K99_06245	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
N2K99_06260	COG1940	carbohydrate kinase activity
N2K99_06280	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
N2K99_06285	COG0515	serine threonine protein kinase
N2K99_06285	COG2815	serine threonine protein kinase
N2K99_06290	COG0741	lytic transglycosylase activity
N2K99_06300	COG0142	geranyltranstransferase activity
N2K99_06310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N2K99_06320	COG2001	Belongs to the MraZ family
N2K99_06325	COG0275	rRNA processing
N2K99_06335	COG0768	penicillin binding
N2K99_06350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N2K99_06355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N2K99_06365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N2K99_06370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N2K99_06380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N2K99_06385	COG1496	oxidoreductase activity
N2K99_06395	COG1799	cell septum assembly
N2K99_06405	COG3599	regulation of cell shape
N2K99_06410	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N2K99_06420	COG0587	DNA-directed DNA polymerase activity
N2K99_06425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N2K99_06430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N2K99_06450	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N2K99_06455	COG0174	glutamine synthetase
N2K99_06460	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N2K99_06465	COG0765	amino acid transport
N2K99_06470	COG1126	abc transporter atp-binding protein
N2K99_06480	COG0657	acetylesterase activity
N2K99_06520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N2K99_06525	COG0321	lipoyl(octanoyl) transferase activity
N2K99_06535	COG0793	Belongs to the peptidase S41A family
N2K99_06535	COG4946	Tricorn protease homolog
N2K99_06540	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N2K99_06545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N2K99_06555	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
N2K99_06560	COG0829	nickel cation binding
N2K99_06565	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N2K99_06570	COG0830	nickel cation binding
N2K99_06575	COG0804	urea catabolic process
N2K99_06580	COG0832	Belongs to the urease beta subunit family
N2K99_06590	COG0831	urea catabolic process
N2K99_06595	COG1764	response to oxidative stress
N2K99_06605	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2K99_06610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N2K99_06615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N2K99_06630	COG1131	(ABC) transporter
N2K99_06645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N2K99_06655	COG0187	DNA topoisomerase II activity
N2K99_06660	COG0501	Belongs to the peptidase M48B family
N2K99_06670	COG1271	oxidase subunit
N2K99_06675	COG1294	oxidase, subunit
N2K99_06680	COG4988	ABC transporter
N2K99_06685	COG0454	-acetyltransferase
N2K99_06685	COG0456	acetyltransferase
N2K99_06695	COG1937	Protein conserved in bacteria
N2K99_06710	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N2K99_06725	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
N2K99_06730	COG1435	thymidine kinase activity
N2K99_06750	COG0756	dUTP diphosphatase activity
N2K99_06775	COG0569	domain protein
N2K99_06780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N2K99_06785	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N2K99_06790	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N2K99_06805	COG0667	Aldo Keto reductase
N2K99_06820	COG1024	Enoyl-CoA hydratase
N2K99_06820	COG1250	3-hydroxyacyl-CoA dehydrogenase
N2K99_06825	COG0183	Belongs to the thiolase family
N2K99_06840	COG0657	acetylesterase activity
N2K99_06885	COG0737	Belongs to the 5'-nucleotidase family
N2K99_06900	COG2318	DinB family
N2K99_06940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N2K99_06955	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N2K99_06960	COG2814	Major facilitator Superfamily
N2K99_06970	COG0183	Belongs to the thiolase family
N2K99_06985	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
N2K99_06995	COG4989	oxidoreductase activity
N2K99_07010	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
N2K99_07030	COG1269	ATP hydrolysis coupled proton transport
N2K99_07055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N2K99_07070	COG2226	methyltransferase
N2K99_07075	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N2K99_07180	COG0242	peptide deformylase activity
N2K99_07185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N2K99_07195	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N2K99_07220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N2K99_07220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N2K99_07225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N2K99_07235	COG4335	DNA alkylation repair
N2K99_07250	COG0477	Major facilitator Superfamily
N2K99_07260	COG0640	Transcriptional regulator
N2K99_07265	COG0798	PFAM Bile acid sodium symporter
N2K99_07270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N2K99_07285	COG2076	Multidrug Resistance protein
N2K99_07295	COG1309	transcriptional regulator
N2K99_07310	COG1476	TRANSCRIPTIONal
N2K99_07355	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_07360	COG1131	(ABC) transporter
N2K99_07370	COG0477	Major facilitator Superfamily
N2K99_07375	COG2272	Belongs to the type-B carboxylesterase lipase family
N2K99_07395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N2K99_07425	COG3655	Transcriptional regulator
N2K99_07440	COG2814	Major facilitator Superfamily
N2K99_07455	COG4941	Belongs to the sigma-70 factor family
N2K99_07460	COG3795	YCII-related domain
N2K99_07480	COG1175	transmembrane transport
N2K99_07485	COG3833	ABC-type maltose transport systems, permease component
N2K99_07500	COG0140	phosphoribosyl-ATP diphosphatase activity
N2K99_07505	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N2K99_07510	COG0107	imidazoleglycerol-phosphate synthase activity
N2K99_07530	COG1064	alcohol dehydrogenase
N2K99_07535	COG2354	Protein conserved in bacteria
N2K99_07550	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N2K99_07570	COG0134	indole-3-glycerol-phosphate synthase activity
N2K99_07575	COG0133	tryptophan synthase activity
N2K99_07580	COG0159	tryptophan synthase activity
N2K99_07585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N2K99_07590	COG0069	glutamate synthase activity
N2K99_07590	COG0070	glutamate synthase
N2K99_07590	COG0067	glutamate synthase
N2K99_07640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N2K99_07645	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N2K99_07655	COG3962	Belongs to the TPP enzyme family
N2K99_07665	COG1082	Xylose isomerase domain protein TIM barrel
N2K99_07670	COG0673	inositol 2-dehydrogenase activity
N2K99_07675	COG1082	Xylose isomerase domain protein TIM barrel
N2K99_07680	COG2814	Major facilitator Superfamily
N2K99_07685	COG3718	enzyme involved in inositol metabolism
N2K99_07695	COG1879	ABC-type sugar transport system periplasmic component
N2K99_07700	COG1172	Belongs to the binding-protein-dependent transport system permease family
N2K99_07710	COG0673	inositol 2-dehydrogenase activity
N2K99_07730	COG1396	sequence-specific DNA binding
N2K99_07745	COG0492	ferredoxin-NADP+ reductase activity
N2K99_07785	COG1595	DNA-templated transcription, initiation
N2K99_07790	COG2197	response regulator
N2K99_07795	COG4585	Histidine kinase
N2K99_07830	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N2K99_07840	COG1329	Transcriptional regulator
N2K99_07845	COG1643	Atp-dependent helicase
N2K99_07870	COG2814	Major facilitator Superfamily
N2K99_07880	COG1960	acyl-CoA dehydrogenase activity
N2K99_07915	COG0488	(ABC) transporter
N2K99_07935	COG1785	Belongs to the alkaline phosphatase family
N2K99_07940	COG0009	L-threonylcarbamoyladenylate synthase
N2K99_07960	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N2K99_07965	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N2K99_07975	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_07995	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
N2K99_08000	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
N2K99_08005	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
N2K99_08020	COG0791	NLP P60 protein
N2K99_08020	COG1388	LysM domain
N2K99_08020	COG3103	Sh3 type 3 domain protein
N2K99_08035	COG1136	(ABC) transporter
N2K99_08045	COG4585	Histidine kinase
N2K99_08055	COG0425	Belongs to the sulfur carrier protein TusA family
N2K99_08060	COG2391	methyltransferase activity
N2K99_08065	COG1215	transferase activity, transferring glycosyl groups
N2K99_08085	COG2272	Belongs to the type-B carboxylesterase lipase family
N2K99_08095	COG0488	(ABC) transporter
N2K99_08100	COG2272	Belongs to the type-B carboxylesterase lipase family
N2K99_08120	COG1607	acyl-coa hydrolase
N2K99_08125	COG0438	transferase activity, transferring glycosyl groups
N2K99_08135	COG1216	Glycosyl transferase, family 2
N2K99_08145	COG1472	Belongs to the glycosyl hydrolase 3 family
N2K99_08150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N2K99_08155	COG0477	Major facilitator Superfamily
N2K99_08160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N2K99_08165	COG3185	4-Hydroxyphenylpyruvate dioxygenase
N2K99_08165	COG1082	Xylose isomerase domain protein TIM barrel
N2K99_08170	COG1414	Transcriptional regulator
N2K99_08180	COG0531	amino acid
N2K99_08185	COG0076	glutamate decarboxylase activity
N2K99_08195	COG2814	Major facilitator Superfamily
N2K99_08210	COG1902	pentaerythritol trinitrate reductase activity
N2K99_08220	COG2050	protein possibly involved in aromatic compounds catabolism
N2K99_08230	COG4552	Acetyltransferase involved in intracellular survival and related
N2K99_08235	COG0539	negative regulation of cytoplasmic translation
N2K99_08255	COG2723	6-phospho-beta-galactosidase activity
N2K99_08265	COG1175	transmembrane transport
N2K99_08275	COG2813	Specifically methylates the guanine in position
N2K99_08280	COG1739	Uncharacterized protein family UPF0029
N2K99_08285	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N2K99_08285	COG0237	dephospho-CoA kinase activity
N2K99_08290	COG0556	nucleotide-excision repair
N2K99_08330	COG4106	trans-aconitate 2-methyltransferase activity
N2K99_08370	COG0322	excinuclease ABC activity
N2K99_08375	COG1660	Displays ATPase and GTPase activities
N2K99_08380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N2K99_08385	COG1481	regulation of sporulation
N2K99_08400	COG0126	phosphoglycerate kinase activity
N2K99_08405	COG0149	triose-phosphate isomerase activity
N2K99_08410	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N2K99_08415	COG0363	glucosamine-6-phosphate deaminase activity
N2K99_08430	COG0166	Belongs to the GPI family
N2K99_08435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N2K99_08445	COG0109	protoheme IX farnesyltransferase activity
N2K99_08450	COG1612	heme a metabolic process
N2K99_08460	COG1131	(ABC) transporter
N2K99_08480	COG0396	ATPase activity
N2K99_08485	COG2151	metal-sulfur cluster biosynthetic enzyme
N2K99_08500	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
N2K99_08515	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N2K99_08520	COG1122	ATPase activity
N2K99_08525	COG1268	BioY protein
N2K99_08530	COG0488	(ABC) transporter
N2K99_08555	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_08560	COG0560	Phosphoserine phosphatase
N2K99_08560	COG3830	Belongs to the UPF0237 family
N2K99_08565	COG1119	ATPase activity
N2K99_08580	COG0254	rRNA binding
N2K99_08605	COG2855	membrane
N2K99_08610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N2K99_08625	COG0297	glycogen (starch) synthase activity
N2K99_08640	COG0183	Belongs to the thiolase family
N2K99_08645	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_08655	COG3844	kynureninase activity
N2K99_08660	COG0589	response to stress
N2K99_08665	COG0531	amino acid
N2K99_08670	COG1253	flavin adenine dinucleotide binding
N2K99_08685	COG0628	permease
N2K99_08695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N2K99_08715	COG1968	undecaprenyl-diphosphatase activity
N2K99_08720	COG0215	cysteine-tRNA ligase activity
N2K99_08730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N2K99_08735	COG1994	Peptidase M50
N2K99_08735	COG0517	IMP dehydrogenase activity
N2K99_08745	COG1222	aaa ATPase
N2K99_08750	COG4122	O-methyltransferase activity
N2K99_08760	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N2K99_08765	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N2K99_08770	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N2K99_08775	COG0545	Peptidyl-prolyl cis-trans isomerase
N2K99_08795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N2K99_08800	COG0805	protein transport
N2K99_08805	COG4581	dead DEAH box helicase
N2K99_08810	COG1574	metal-dependent hydrolase with the TIM-barrel fold
N2K99_08815	COG1216	Glycosyl transferase, family 2
N2K99_08840	COG0823	Involved in the tonB-independent uptake of proteins
N2K99_08840	COG1506	peptidase
N2K99_08840	COG4946	Tricorn protease homolog
N2K99_08845	COG0242	peptide deformylase activity
N2K99_08885	COG4941	Belongs to the sigma-70 factor family
N2K99_08890	COG0366	Alpha amylase catalytic
N2K99_08935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N2K99_08940	COG1845	cytochrome c oxidase, subunit III
N2K99_08945	COG2010	Cytochrome c
N2K99_08950	COG0723	plastoquinol--plastocyanin reductase activity
N2K99_08955	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N2K99_08965	COG2188	Transcriptional regulator
N2K99_08975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N2K99_08980	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N2K99_09000	COG0167	dihydroorotate dehydrogenase activity
N2K99_09010	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N2K99_09015	COG1381	Involved in DNA repair and RecF pathway recombination
N2K99_09020	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N2K99_09025	COG1316	TRANSCRIPTIONal
N2K99_09030	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N2K99_09040	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N2K99_09060	COG0484	heat shock protein binding
N2K99_09065	COG1420	regulation of RNA biosynthetic process
N2K99_09085	COG0481	GTPase activity
N2K99_09095	COG0268	Binds directly to 16S ribosomal RNA
N2K99_09215	COG1307	EDD domain protein, DegV family
N2K99_09220	COG0495	leucyl-tRNA aminoacylation
N2K99_09230	COG1088	dTDP-glucose 4,6-dehydratase activity
N2K99_09235	COG0385	Bile acid
N2K99_09240	COG2072	flavoprotein involved in K transport
N2K99_09245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N2K99_09250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N2K99_09255	COG0656	L-ascorbic acid biosynthetic process
N2K99_09265	COG0438	transferase activity, transferring glycosyl groups
N2K99_09270	COG2130	NADP-dependent
N2K99_09275	COG1846	Transcriptional regulator
N2K99_09290	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N2K99_09310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N2K99_09320	COG1758	RNA polymerase activity
N2K99_09325	COG0194	GDP metabolic process
N2K99_09330	COG0194	GDP metabolic process
N2K99_09335	COG0284	orotidine-5'-phosphate decarboxylase activity
N2K99_09340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N2K99_09345	COG0505	Belongs to the CarA family
N2K99_09355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N2K99_09360	COG0540	Belongs to the ATCase OTCase family
N2K99_09365	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N2K99_09375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N2K99_09380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N2K99_09385	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N2K99_09395	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N2K99_09400	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N2K99_09410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N2K99_09415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N2K99_09430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N2K99_09450	COG0384	phenazine biosynthesis protein PhzF
N2K99_09455	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N2K99_09465	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N2K99_09480	COG2197	response regulator
N2K99_09485	COG0124	histidyl-tRNA synthetase
N2K99_09495	COG1196	nuclear chromosome segregation
N2K99_09505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N2K99_09510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N2K99_09515	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N2K99_09525	COG2255	four-way junction helicase activity
N2K99_09530	COG0632	four-way junction helicase activity
N2K99_09535	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N2K99_09540	COG0217	transcriptional regulatory protein
N2K99_09545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N2K99_09570	COG2226	methyltransferase
N2K99_09585	COG0339	signal peptide processing
N2K99_09590	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N2K99_09600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N2K99_09605	COG0587	DNA-directed DNA polymerase activity
N2K99_09630	COG2365	Tyrosine phosphatase family
N2K99_09660	COG2135	peptidase activity
N2K99_09715	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_09715	COG3347	Dehydrogenase
N2K99_09740	COG3813	Protein conserved in bacteria
N2K99_09760	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
N2K99_09815	COG0667	Aldo Keto reductase
N2K99_09820	COG2135	peptidase activity
N2K99_09835	COG0656	L-ascorbic acid biosynthetic process
N2K99_09885	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_09925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N2K99_09940	COG1131	(ABC) transporter
N2K99_09950	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
N2K99_09955	COG3639	organic phosphonate transmembrane transporter activity
N2K99_09975	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N2K99_09980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N2K99_09985	COG1780	Probably involved in ribonucleotide reductase function
N2K99_10080	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N2K99_10090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N2K99_10095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N2K99_10100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N2K99_10105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N2K99_10110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N2K99_10115	COG1530	ribonuclease E activity
N2K99_10135	COG0105	UTP biosynthetic process
N2K99_10145	COG0285	dihydrofolate synthase activity
N2K99_10150	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N2K99_10170	COG0525	valine-tRNA ligase activity
N2K99_10175	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N2K99_10180	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N2K99_10185	COG0740	serine-type endopeptidase activity
N2K99_10195	COG0544	peptidyl-prolyl cis-trans isomerase activity
N2K99_10215	COG0698	ribose 5-phosphate isomerase
N2K99_10235	COG0668	transmembrane transport
N2K99_10255	COG1946	Acyl-CoA thioesterase
N2K99_10270	COG0629	single-stranded DNA binding
N2K99_10365	COG0242	peptide deformylase activity
N2K99_10385	COG3022	response to hydroperoxide
N2K99_10395	COG1579	Zn-ribbon protein possibly nucleic acid-binding
N2K99_10400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N2K99_10405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N2K99_10415	COG1045	serine acetyltransferase
N2K99_10420	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N2K99_10450	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N2K99_10455	COG1175	transmembrane transport
N2K99_10460	COG0395	ABC-type sugar transport system, permease component
N2K99_10480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N2K99_10485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N2K99_10500	COG4974	Belongs to the 'phage' integrase family
N2K99_10520	COG0792	nuclease activity
N2K99_10525	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_10550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N2K99_10555	COG0681	Belongs to the peptidase S26 family
N2K99_10560	COG0681	Belongs to the peptidase S26 family
N2K99_10565	COG0335	large ribosomal subunit rRNA binding
N2K99_10570	COG0336	Belongs to the RNA methyltransferase TrmD family
N2K99_10575	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N2K99_10580	COG1837	Belongs to the UPF0109 family
N2K99_10585	COG0228	four-way junction DNA binding
N2K99_10590	COG2514	catechol 2,3-dioxygenase activity
N2K99_10630	COG0552	protein localization to endoplasmic reticulum
N2K99_10635	COG0477	Major facilitator Superfamily
N2K99_10645	COG1196	nuclear chromosome segregation
N2K99_10650	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N2K99_10655	COG0318	PFAM AMP-dependent synthetase and ligase
N2K99_10660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N2K99_10680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N2K99_10695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N2K99_10700	COG0571	ribonuclease III activity
N2K99_10705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N2K99_10715	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N2K99_10730	COG0742	ribosomal rna small subunit methyltransferase
N2K99_10740	COG1461	Dihydroxyacetone kinase
N2K99_10745	COG1316	TRANSCRIPTIONal
N2K99_10755	COG1181	Belongs to the D-alanine--D-alanine ligase family
N2K99_10760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N2K99_10770	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N2K99_10775	COG0066	3-isopropylmalate dehydratase activity
N2K99_10780	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N2K99_10785	COG1414	Transcriptional regulator
N2K99_10815	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N2K99_10825	COG0179	Fumarylacetoacetate (FAA) hydrolase
N2K99_10850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N2K99_10855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N2K99_10860	COG0473	3-isopropylmalate dehydrogenase activity
N2K99_10865	COG4585	Histidine kinase
N2K99_10870	COG2197	response regulator
N2K99_10900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N2K99_10905	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N2K99_10910	COG0440	acetolactate synthase activity
N2K99_10920	COG0129	dihydroxy-acid dehydratase activity
N2K99_10955	COG1690	Belongs to the RtcB family
N2K99_10975	COG0747	negative chemotaxis
N2K99_10980	COG0601	transmembrane transport
N2K99_10985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N2K99_11000	COG0747	negative chemotaxis
N2K99_11005	COG0579	oxidoreductase
N2K99_11010	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N2K99_11035	COG2814	Major facilitator Superfamily
N2K99_11040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N2K99_11045	COG1522	sequence-specific DNA binding
N2K99_11050	COG1113	amino acid transport
N2K99_11060	COG0022	dehydrogenase e1 component
N2K99_11065	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2K99_11075	COG0515	serine threonine protein kinase
N2K99_11090	COG0419	ATPase involved in DNA repair
N2K99_11095	COG0420	3'-5' exonuclease activity
N2K99_11100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N2K99_11115	COG0586	Pfam SNARE associated Golgi protein
N2K99_11120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N2K99_11125	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N2K99_11140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N2K99_11150	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N2K99_11160	COG1335	isochorismatase
N2K99_11185	COG1902	pentaerythritol trinitrate reductase activity
N2K99_11210	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
N2K99_11225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N2K99_11235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N2K99_11240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N2K99_11245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N2K99_11250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N2K99_11255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N2K99_11260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N2K99_11265	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N2K99_11270	COG0356	it plays a direct role in the translocation of protons across the membrane
N2K99_11285	COG1086	Polysaccharide biosynthesis protein
N2K99_11305	COG0009	L-threonylcarbamoyladenylate synthase
N2K99_11310	COG2890	protein-(glutamine-N5) methyltransferase activity
N2K99_11315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N2K99_11325	COG0083	homoserine kinase activity
N2K99_11330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N2K99_11335	COG0460	homoserine dehydrogenase
N2K99_11345	COG0018	arginyl-trna synthetase
N2K99_11360	COG1017	nitric oxide dioxygenase activity
N2K99_11360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N2K99_11435	COG1643	Atp-dependent helicase
N2K99_11440	COG0537	adenosine 5'-monophosphoramidase activity
N2K99_11460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N2K99_11465	COG1121	(ABC) transporter
N2K99_11480	COG1253	flavin adenine dinucleotide binding
N2K99_11485	COG0567	Dehydrogenase, E1 component
N2K99_11485	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2K99_11505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N2K99_11510	COG4172	Belongs to the ABC transporter superfamily
N2K99_11520	COG1024	Enoyl-CoA hydratase
N2K99_11540	COG1960	acyl-CoA dehydrogenase activity
N2K99_11550	COG1595	DNA-templated transcription, initiation
N2K99_11560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N2K99_11570	COG0483	inositol monophosphate 1-phosphatase activity
N2K99_11580	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N2K99_11585	COG0366	Alpha amylase catalytic
N2K99_11615	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N2K99_11620	COG0739	heme binding
N2K99_11625	COG2177	Part of the ABC transporter FtsEX involved in
N2K99_11630	COG2884	Cell division ATP-binding protein ftsE
N2K99_11635	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N2K99_11705	COG1086	Polysaccharide biosynthesis protein
N2K99_11710	COG1216	Glycosyl transferase, family 2
N2K99_11745	COG1216	Glycosyl transferase, family 2
N2K99_11755	COG2755	lipolytic protein G-D-S-L family
N2K99_11755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N2K99_11760	COG1674	ftsk spoiiie
N2K99_11780	COG2902	Dehydrogenase
N2K99_11815	COG0653	protein targeting
N2K99_11820	COG3214	Protein conserved in bacteria
N2K99_11825	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N2K99_11835	COG5401	PFAM Sporulation and spore germination
N2K99_11840	COG5002	protein histidine kinase activity
N2K99_11845	COG0745	RESPONSE REGULATOR receiver
N2K99_11865	COG0714	Associated with various cellular activities
N2K99_11890	COG0482	sulfurtransferase activity
N2K99_11900	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N2K99_11905	COG0484	heat shock protein binding
N2K99_11910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N2K99_11915	COG2226	methyltransferase
N2K99_11925	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
N2K99_11935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N2K99_11945	COG1842	Phage shock protein A
N2K99_11960	COG1615	UPF0182 protein
N2K99_11965	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N2K99_12005	COG1131	(ABC) transporter
N2K99_12015	COG0210	DNA helicase
N2K99_12040	COG2011	ABC-type metal ion transport system permease component
N2K99_12050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N2K99_12055	COG0113	porphobilinogen synthase activity
N2K99_12065	COG0181	hydroxymethylbilane synthase activity
N2K99_12070	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N2K99_12075	COG3253	May function as heme-dependent peroxidase
N2K99_12080	COG1231	oxidoreductase activity
N2K99_12085	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N2K99_12090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N2K99_12120	COG0513	Belongs to the DEAD box helicase family
N2K99_12130	COG0613	PHP domain protein
N2K99_12135	COG0006	proline dipeptidase activity
N2K99_12145	COG2239	Acts as a magnesium transporter
N2K99_12160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N2K99_12170	COG1595	DNA-templated transcription, initiation
N2K99_12180	COG0024	Methionine aminopeptidase
N2K99_12185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N2K99_12200	COG0519	Catalyzes the synthesis of GMP from XMP
N2K99_12210	COG1611	Belongs to the LOG family
N2K99_12215	COG1126	abc transporter atp-binding protein
N2K99_12220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N2K99_12225	COG0765	amino acid transport
N2K99_12230	COG0765	amino acid transport
N2K99_12235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N2K99_12240	COG2171	N-acyltransferase activity
N2K99_12250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N2K99_12280	COG1217	gtp-binding protein TYPA
N2K99_12290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N2K99_12295	COG0601	transmembrane transport
N2K99_12350	COG0012	GTP binding
N2K99_12355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N2K99_12365	COG1570	exodeoxyribonuclease VII activity
N2K99_12370	COG1722	exodeoxyribonuclease VII activity
N2K99_12385	COG1174	glycine betaine transport
N2K99_12390	COG1174	glycine betaine transport
N2K99_12400	COG0494	nUDIX hydrolase
N2K99_12405	COG2971	BadF BadG BcrA BcrD
N2K99_12435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N2K99_12440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N2K99_12460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N2K99_12460	COG0519	Catalyzes the synthesis of GMP from XMP
N2K99_12480	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N2K99_12485	COG0516	GMP reductase activity
N2K99_12495	COG0459	protein refolding
N2K99_12500	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N2K99_12510	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2K99_12515	COG4605	iron ion homeostasis
N2K99_12520	COG4604	ABC transporter, ATP-binding protein
N2K99_12550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N2K99_12560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N2K99_12565	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N2K99_12570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N2K99_12575	COG1247	-acetyltransferase
N2K99_12585	COG0802	atpase or kinase
N2K99_12590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N2K99_12600	COG0667	Aldo Keto reductase
N2K99_12625	COG0736	holo-[acyl-carrier-protein] synthase activity
N2K99_12635	COG1072	(Pantothenic acid kinase))
N2K99_12640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N2K99_12645	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N2K99_12650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N2K99_12655	COG0101	tRNA pseudouridine synthase activity
N2K99_12660	COG0203	ribosomal protein L17
N2K99_12665	COG0202	RNA polymerase activity
N2K99_12670	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N2K99_12675	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N2K99_12680	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N2K99_12685	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N2K99_12690	COG0584	glycerophosphoryl diester phosphodiesterase
N2K99_12695	COG0024	Methionine aminopeptidase
N2K99_12700	COG0563	adenylate kinase activity
N2K99_12710	COG0200	Binds to the 23S rRNA
N2K99_12715	COG1841	ribosomal large subunit assembly
N2K99_12720	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N2K99_12730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N2K99_12735	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N2K99_12740	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N2K99_12745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N2K99_12750	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N2K99_12755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N2K99_12765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N2K99_12770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N2K99_12775	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N2K99_12780	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N2K99_12785	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N2K99_12790	COG0089	rRNA binding
N2K99_12795	COG0088	Forms part of the polypeptide exit tunnel
N2K99_12800	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N2K99_12805	COG0051	transcription antitermination factor activity, RNA binding
N2K99_12820	COG0318	PFAM AMP-dependent synthetase and ligase
N2K99_12830	COG0446	pyridine nucleotide-disulphide oxidoreductase
N2K99_12830	COG1902	pentaerythritol trinitrate reductase activity
N2K99_12835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N2K99_12840	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N2K99_12845	COG0049	tRNA binding
N2K99_12850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N2K99_12855	COG1414	Transcriptional regulator
N2K99_12860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N2K99_12870	COG0183	Belongs to the thiolase family
N2K99_12875	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N2K99_12890	COG3485	protocatechuate 3,4-dioxygenase
N2K99_12895	COG3485	protocatechuate 3,4-dioxygenase
N2K99_12915	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N2K99_12920	COG0085	RNA polymerase activity
N2K99_12930	COG0222	ribosome binding
N2K99_12935	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N2K99_12945	COG0081	regulation of translation
N2K99_12950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N2K99_12970	COG0436	Aminotransferase
N2K99_12975	COG2197	response regulator
N2K99_13020	COG3485	protocatechuate 3,4-dioxygenase
N2K99_13030	COG0745	RESPONSE REGULATOR receiver
N2K99_13035	COG0456	acetyltransferase
N2K99_13040	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N2K99_13050	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N2K99_13055	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N2K99_13060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N2K99_13070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N2K99_13080	COG2030	dehydratase
N2K99_13105	COG0693	protein deglycase activity
N2K99_13120	COG0515	serine threonine protein kinase
N2K99_13120	COG2815	serine threonine protein kinase
N2K99_13135	COG5650	phosphatidylinositol metabolic process
N2K99_13140	COG1228	amidohydrolase
N2K99_13175	COG1063	alcohol dehydrogenase
N2K99_13180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N2K99_13200	COG1666	GTP binding
N2K99_13205	COG0406	alpha-ribazole phosphatase activity
N2K99_13210	COG0501	Belongs to the peptidase M48B family
N2K99_13220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N2K99_13260	COG1233	COG1233 Phytoene dehydrogenase and related
N2K99_13270	COG0142	geranyltranstransferase activity
N2K99_13275	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
N2K99_13380	COG0142	geranyltranstransferase activity
N2K99_13390	COG2226	methyltransferase
N2K99_13400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N2K99_13405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N2K99_13410	COG0765	amino acid transport
N2K99_13425	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
N2K99_13430	COG0473	3-isopropylmalate dehydrogenase activity
N2K99_13435	COG0471	metal ion transport
N2K99_13440	COG4948	Mandelate Racemase Muconate Lactonizing
N2K99_13465	COG0022	dehydrogenase e1 component
N2K99_13475	COG1522	sequence-specific DNA binding
N2K99_13490	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N2K99_13495	COG2151	metal-sulfur cluster biosynthetic enzyme
N2K99_13500	COG3396	Phenylacetate-CoA oxygenase
N2K99_13505	COG3460	Phenylacetate-CoA oxygenase
N2K99_13510	COG3396	Phenylacetate-CoA oxygenase
N2K99_13530	COG2723	6-phospho-beta-galactosidase activity
N2K99_13535	COG0395	ABC-type sugar transport system, permease component
N2K99_13550	COG0586	Pfam SNARE associated Golgi protein
N2K99_13590	COG1012	belongs to the aldehyde dehydrogenase family
N2K99_13590	COG2030	dehydratase
N2K99_13605	COG1793	dna ligase
N2K99_13615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N2K99_13630	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N2K99_13655	COG1140	nitrate reductase beta subunit
N2K99_13665	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
N2K99_13690	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N2K99_13700	COG0785	Cytochrome C biogenesis protein
N2K99_13710	COG0406	alpha-ribazole phosphatase activity
N2K99_13730	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
N2K99_13755	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N2K99_13760	COG0640	Transcriptional regulator
N2K99_13765	COG0123	including yeast histone deacetylase and acetoin utilization protein
N2K99_13770	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N2K99_13775	COG0569	domain protein
N2K99_13785	COG1082	Xylose isomerase domain protein TIM barrel
N2K99_13790	COG0248	Ppx GppA phosphatase
N2K99_13795	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N2K99_13795	COG1754	DNA topoisomerase type I activity
N2K99_13800	COG2890	protein-(glutamine-N5) methyltransferase activity
N2K99_13805	COG1053	succinate dehydrogenase
N2K99_13810	COG1054	Belongs to the UPF0176 family
N2K99_13820	COG1111	helicase
N2K99_13820	COG1205	dead DEAH box helicase
N2K99_13860	COG2072	flavoprotein involved in K transport
N2K99_13870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N2K99_13870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N2K99_13880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N2K99_13890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N2K99_13895	COG1764	response to oxidative stress
N2K99_13905	COG0477	Major facilitator Superfamily
N2K99_13910	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N2K99_13945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N2K99_13950	COG1408	metallophosphoesterase
N2K99_13960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N2K99_13965	COG0151	Belongs to the GarS family
N2K99_13990	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N2K99_14005	COG0542	response to heat
N2K99_14015	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N2K99_14020	COG1012	belongs to the aldehyde dehydrogenase family
N2K99_14030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N2K99_14035	COG3304	Inner membrane component domain
N2K99_14050	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N2K99_14080	COG0484	heat shock protein binding
N2K99_14085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N2K99_14090	COG0443	Heat shock 70 kDa protein
N2K99_14105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N2K99_14120	COG4172	Belongs to the ABC transporter superfamily
N2K99_14140	COG2212	antiporter activity
N2K99_14145	COG1863	multisubunit Na H antiporter MnhE subunit
N2K99_14150	COG0651	ATP synthesis coupled electron transport
N2K99_14155	COG1006	Multisubunit Na H antiporter MnhC subunit
N2K99_14160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N2K99_14160	COG2111	Na H antiporter
N2K99_14170	COG0717	Belongs to the dCTP deaminase family
N2K99_14175	COG3483	tryptophan 2,3-dioxygenase activity
N2K99_14200	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
N2K99_14240	COG3336	cytochrome c oxidase
N2K99_14245	COG0776	regulation of translation
N2K99_14250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N2K99_14255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N2K99_14260	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N2K99_14265	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N2K99_14275	COG0477	Major facilitator Superfamily
N2K99_14285	COG1597	lipid kinase activity
N2K99_14290	COG0739	heme binding
N2K99_14290	COG0741	lytic transglycosylase activity
N2K99_14290	COG1196	nuclear chromosome segregation
N2K99_14295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2K99_14300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2K99_14315	COG1120	ATPase activity
N2K99_14320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2K99_14325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2K99_14330	COG0435	Glutathione S-transferase
N2K99_14345	COG1113	amino acid transport
N2K99_14350	COG1295	ribonuclease BN
N2K99_14370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N2K99_14375	COG2146	nitrite reductase [NAD(P)H] activity
N2K99_14400	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_14405	COG1960	acyl-CoA dehydrogenase activity
N2K99_14440	COG1414	Transcriptional regulator
N2K99_14445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N2K99_14455	COG1063	alcohol dehydrogenase
N2K99_14475	COG1174	glycine betaine transport
N2K99_14485	COG1174	glycine betaine transport
N2K99_14490	COG0531	amino acid
N2K99_14505	COG1473	amidohydrolase
N2K99_14510	COG4585	Histidine kinase
N2K99_14520	COG4152	abc transporter atp-binding protein
N2K99_14555	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_14560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N2K99_14565	COG1012	belongs to the aldehyde dehydrogenase family
N2K99_14585	COG0318	PFAM AMP-dependent synthetase and ligase
N2K99_14595	COG4221	oxidoreductase activity
N2K99_14615	COG0028	Belongs to the TPP enzyme family
N2K99_14630	COG1129	ABC transporter
N2K99_14650	COG0596	Alpha beta hydrolase
N2K99_14655	COG5002	protein histidine kinase activity
N2K99_14675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2K99_14685	COG1012	belongs to the aldehyde dehydrogenase family
N2K99_14690	COG2860	membrane
N2K99_14700	COG1063	alcohol dehydrogenase
N2K99_14720	COG3386	PFAM SMP-30 Gluconolaconase
N2K99_14730	COG2610	gluconate transmembrane transporter activity
N2K99_14735	COG0531	amino acid
N2K99_14765	COG0492	ferredoxin-NADP+ reductase activity
N2K99_14835	COG1414	Transcriptional regulator
N2K99_14840	COG2217	Heavy metal translocating P-type atpase
N2K99_14845	COG0598	Magnesium transport protein CorA
N2K99_14855	COG0477	Major facilitator Superfamily
N2K99_14865	COG3546	catalase activity
N2K99_14875	COG0500	methyltransferase
N2K99_14890	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_14900	COG0477	Major facilitator Superfamily
N2K99_14910	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N2K99_14920	COG2301	Belongs to the HpcH HpaI aldolase family
N2K99_14925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N2K99_14935	COG3257	ureidoglycine aminohydrolase activity
N2K99_14945	COG2233	PERMEase
N2K99_14970	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
N2K99_14970	COG3608	succinylglutamate desuccinylase aspartoacylase
N2K99_14980	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N2K99_14990	COG0697	spore germination
N2K99_14995	COG1846	Transcriptional regulator
N2K99_15035	COG5650	phosphatidylinositol metabolic process
N2K99_15045	COG1846	Transcriptional regulator
N2K99_15055	COG0318	PFAM AMP-dependent synthetase and ligase
N2K99_15070	COG0477	Major facilitator Superfamily
N2K99_15080	COG3971	2-oxopent-4-enoate hydratase activity
N2K99_15090	COG1012	belongs to the aldehyde dehydrogenase family
N2K99_15120	COG1902	pentaerythritol trinitrate reductase activity
N2K99_15140	COG1609	Transcriptional regulator
N2K99_15160	COG0366	Alpha amylase catalytic
N2K99_15165	COG2314	TM2 domain
N2K99_15175	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_15215	COG2314	TM2 domain
N2K99_15235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N2K99_15250	COG2076	Multidrug Resistance protein
N2K99_15270	COG2207	Transcriptional regulator
N2K99_15275	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_15300	COG1742	UPF0060 membrane protein
N2K99_15315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N2K99_15350	COG0656	L-ascorbic acid biosynthetic process
N2K99_15375	COG1414	Transcriptional regulator
N2K99_15385	COG0280	phosphate acetyltransferase
N2K99_15390	COG2855	membrane
N2K99_15395	COG0247	lactate metabolic process
N2K99_15395	COG0277	FAD linked oxidase domain protein
N2K99_15455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N2K99_15460	COG1937	Protein conserved in bacteria
N2K99_15480	COG0477	Major facilitator Superfamily
N2K99_15495	COG0596	Alpha beta hydrolase
N2K99_15505	COG1132	(ABC) transporter
N2K99_15525	COG2814	Major facilitator Superfamily
N2K99_15530	COG2409	Drug exporters of the RND superfamily
N2K99_15540	COG0667	Aldo Keto reductase
N2K99_15550	COG0277	FAD linked oxidase domain protein
N2K99_15555	COG1620	l-lactate permease
N2K99_15560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N2K99_15565	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_15575	COG1115	amino acid carrier protein
N2K99_15590	COG0509	glycine decarboxylation via glycine cleavage system
N2K99_15595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N2K99_15600	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N2K99_15600	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N2K99_15605	COG1113	amino acid transport
N2K99_15640	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N2K99_15660	COG0686	Belongs to the AlaDH PNT family
N2K99_15675	COG1309	transcriptional regulator
N2K99_15700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N2K99_15705	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2K99_15710	COG0022	dehydrogenase e1 component
N2K99_15720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N2K99_15725	COG1950	PFAM Membrane protein of
N2K99_15740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N2K99_15745	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N2K99_15755	COG0590	tRNA wobble adenosine to inosine editing
N2K99_15760	COG0789	Transcriptional regulator
N2K99_15775	COG0395	ABC-type sugar transport system, permease component
N2K99_15780	COG1175	transmembrane transport
N2K99_15830	COG2197	response regulator
N2K99_15845	COG2205	protein histidine kinase activity
N2K99_15850	COG0745	RESPONSE REGULATOR receiver
N2K99_15855	COG1329	Transcriptional regulator
N2K99_15880	COG1063	alcohol dehydrogenase
N2K99_15885	COG5002	protein histidine kinase activity
N2K99_15905	COG0246	Mannitol dehydrogenase
N2K99_15935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N2K99_15940	COG1595	DNA-templated transcription, initiation
N2K99_15945	COG0318	PFAM AMP-dependent synthetase and ligase
N2K99_15975	COG1191	sigma factor activity
N2K99_15980	COG1619	proteins homologs of microcin C7 resistance protein MccF
N2K99_15990	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N2K99_16005	COG0438	transferase activity, transferring glycosyl groups
N2K99_16010	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N2K99_16015	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N2K99_16015	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N2K99_16020	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_16025	COG0697	spore germination
N2K99_16030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N2K99_16045	COG3655	Transcriptional regulator
N2K99_16080	COG1940	carbohydrate kinase activity
N2K99_16105	COG0477	Major facilitator Superfamily
N2K99_16115	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_16125	COG1960	acyl-CoA dehydrogenase activity
N2K99_16140	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_16155	COG1309	transcriptional regulator
N2K99_16165	COG1012	belongs to the aldehyde dehydrogenase family
N2K99_16170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N2K99_16170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N2K99_16175	COG1216	Glycosyl transferase, family 2
N2K99_16195	COG2814	Major facilitator Superfamily
N2K99_16210	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N2K99_16215	COG3583	domain protein
N2K99_16220	COG0531	amino acid
N2K99_16230	COG0305	Participates in initiation and elongation during chromosome replication
N2K99_16235	COG0359	binds to the 23S rRNA
N2K99_16240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N2K99_16250	COG0360	Binds together with S18 to 16S ribosomal RNA
N2K99_16255	COG1362	aminopeptidase activity
N2K99_16285	COG0738	Major facilitator superfamily
N2K99_16335	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N2K99_16340	COG0438	transferase activity, transferring glycosyl groups
N2K99_16350	COG0406	alpha-ribazole phosphatase activity
N2K99_16355	COG0617	tRNA 3'-terminal CCA addition
N2K99_16375	COG0492	ferredoxin-NADP+ reductase activity
N2K99_16380	COG3118	belongs to the thioredoxin family
N2K99_16385	COG0860	N-Acetylmuramoyl-L-alanine amidase
N2K99_16385	COG3409	Peptidoglycan-binding domain 1 protein
N2K99_16390	COG2226	methyltransferase
N2K99_16415	COG1192	Involved in chromosome partitioning
N2K99_16420	COG0357	Ribosomal RNA small subunit methyltransferase G
N2K99_16430	COG0706	membrane insertase activity
N2K99_16440	COG0594	ribonuclease P activity
N2K99_16670	COG3177	Filamentation induced by cAMP protein fic
N2K99_16705	COG5479	isomerase activity
N2K99_16705	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N2K99_16750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N2K99_16875	COG0328	RNA-DNA hybrid ribonuclease activity
N2K99_17000	COG1842	Phage shock protein A
N2K99_17035	COG0741	lytic transglycosylase activity
N2K99_17075	COG2755	lipolytic protein G-D-S-L family
N2K99_17075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N2K99_17190	COG1131	(ABC) transporter
N2K99_17195	COG1191	sigma factor activity
N2K99_17215	COG0492	ferredoxin-NADP+ reductase activity
N2K99_17265	COG0588	phosphoglycerate mutase activity
N2K99_17305	COG0756	dUTP diphosphatase activity
N2K99_17580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N2K99_17615	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N2K99_17635	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N2K99_17645	COG0542	response to heat
N2K99_17725	COG2805	Type II/IV secretion system protein
N2K99_17740	COG2304	oxidoreductase activity
N2K99_17760	COG3177	Filamentation induced by cAMP protein fic
N2K99_17840	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N2K99_17915	COG0754	glutathionylspermidine amidase activity
N2K99_17960	COG1690	Belongs to the RtcB family
N2K99_18045	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N2K99_18065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N2K99_18070	COG1780	Probably involved in ribonucleotide reductase function
N2K99_18175	COG2268	Band 7 protein
N2K99_18195	COG0739	heme binding
N2K99_18215	COG1028	Short-chain dehydrogenase reductase Sdr
N2K99_18300	COG2894	cell division
N2K99_18335	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N2K99_18550	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N2K99_18795	COG1793	dna ligase
N2K99_18970	COG1674	ftsk spoiiie