locus-tag	class	description
N2L00_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N2L00_00010	COG0592	DNA-directed DNA polymerase activity
N2L00_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N2L00_00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
N2L00_00025	COG0187	DNA topoisomerase II activity
N2L00_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N2L00_00035	COG3266	domain, Protein
N2L00_00070	COG0705	Rhomboid family
N2L00_00080	COG3764	Sortase (surface protein transpeptidase)
N2L00_00095	COG0515	serine threonine protein kinase
N2L00_00095	COG2815	serine threonine protein kinase
N2L00_00100	COG0515	serine threonine protein kinase
N2L00_00105	COG0768	penicillin binding
N2L00_00120	COG1716	ATPase activity
N2L00_00125	COG1716	ATPase activity
N2L00_00145	COG0346	lactoylglutathione lyase activity
N2L00_00150	COG0025	NhaP-type Na H and K H
N2L00_00160	COG3265	gluconokinase activity
N2L00_00165	COG2186	Transcriptional regulator
N2L00_00170	COG0783	Belongs to the Dps family
N2L00_00180	COG0723	plastoquinol--plastocyanin reductase activity
N2L00_00185	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_00205	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
N2L00_00240	COG1376	ErfK ybiS ycfS ynhG family protein
N2L00_00245	COG0702	epimerase
N2L00_00270	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_00275	COG1609	Transcriptional regulator
N2L00_00295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N2L00_00305	COG0561	phosphatase activity
N2L00_00310	COG0671	phosphoesterase, PA-phosphatase related
N2L00_00315	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N2L00_00320	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
N2L00_00330	COG1929	Belongs to the glycerate kinase type-1 family
N2L00_00335	COG2233	PERMEase
N2L00_00345	COG1012	belongs to the aldehyde dehydrogenase family
N2L00_00365	COG3104	oligopeptide transport
N2L00_00370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N2L00_00380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N2L00_00400	COG1597	lipid kinase activity
N2L00_00405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N2L00_00410	COG0561	phosphatase activity
N2L00_00425	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N2L00_00430	COG2027	D-alanyl-D-alanine carboxypeptidase
N2L00_00440	COG0037	tRNA processing
N2L00_00450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N2L00_00455	COG0302	gtp cyclohydrolase
N2L00_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N2L00_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N2L00_00495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N2L00_00500	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N2L00_00520	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N2L00_00525	COG3237	CsbD-like
N2L00_00530	COG2376	Dihydroxyacetone kinase
N2L00_00535	COG1461	Dihydroxyacetone kinase
N2L00_00555	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
N2L00_00570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N2L00_00580	COG0581	inorganic phosphate transmembrane transporter activity
N2L00_00585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N2L00_00590	COG0306	phosphate transporter
N2L00_00640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N2L00_00640	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2L00_00645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N2L00_00650	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N2L00_00650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2L00_00650	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N2L00_00675	COG2733	membrane
N2L00_00680	COG3387	PFAM Glycoside hydrolase 15-related
N2L00_00695	COG2814	Major facilitator Superfamily
N2L00_00710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N2L00_00715	COG0280	phosphate acetyltransferase
N2L00_00715	COG0857	belongs to the CobB CobQ family
N2L00_00720	COG0531	amino acid
N2L00_00730	COG4122	O-methyltransferase activity
N2L00_00750	COG2252	PERMEase
N2L00_00795	COG1302	Protein conserved in bacteria
N2L00_00835	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N2L00_00850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N2L00_00850	COG0357	Ribosomal RNA small subunit methyltransferase G
N2L00_00855	COG0191	fructose-bisphosphate aldolase activity
N2L00_00885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N2L00_00905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N2L00_00920	COG1832	CoA-binding protein
N2L00_00935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N2L00_00940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2L00_00950	COG1116	anion transmembrane transporter activity
N2L00_00960	COG1832	CoA-binding protein
N2L00_00970	COG2315	Protein conserved in bacteria
N2L00_00985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N2L00_00990	COG0047	phosphoribosylformylglycinamidine synthase activity
N2L00_01040	COG4555	ABC transporter
N2L00_01050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N2L00_01065	COG0363	glucosamine-6-phosphate deaminase activity
N2L00_01090	COG3548	integral membrane protein
N2L00_01115	COG2197	response regulator
N2L00_01135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N2L00_01150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N2L00_01150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N2L00_01230	COG0028	Belongs to the TPP enzyme family
N2L00_01285	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N2L00_01310	COG0492	ferredoxin-NADP+ reductase activity
N2L00_01320	COG0384	phenazine biosynthesis protein PhzF
N2L00_01325	COG0492	ferredoxin-NADP+ reductase activity
N2L00_01345	COG0667	Aldo Keto reductase
N2L00_01370	COG3321	synthase
N2L00_01370	COG0604	alcohol dehydrogenase
N2L00_01370	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_01390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N2L00_01400	COG0542	response to heat
N2L00_01420	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_01430	COG1309	transcriptional regulator
N2L00_01450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N2L00_01460	COG0386	Belongs to the glutathione peroxidase family
N2L00_01495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N2L00_01525	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N2L00_01530	COG2224	Isocitrate lyase
N2L00_01535	COG1396	sequence-specific DNA binding
N2L00_01540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N2L00_01550	COG0351	phosphomethylpyrimidine kinase
N2L00_01555	COG1309	transcriptional regulator
N2L00_01575	COG0343	queuine tRNA-ribosyltransferase activity
N2L00_01630	COG0564	pseudouridine synthase activity
N2L00_01635	COG0659	secondary active sulfate transmembrane transporter activity
N2L00_01640	COG0515	serine threonine protein kinase
N2L00_01645	COG1846	Transcriptional regulator
N2L00_01655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2L00_01660	COG1120	ATPase activity
N2L00_01675	COG0583	DNA-binding transcription factor activity
N2L00_01680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N2L00_01685	COG1201	RNA secondary structure unwinding
N2L00_01705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N2L00_01710	COG1752	Esterase of the alpha-beta hydrolase superfamily
N2L00_01745	COG4589	Belongs to the CDS family
N2L00_01760	COG0590	tRNA wobble adenosine to inosine editing
N2L00_01765	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N2L00_01775	COG2062	phosphohistidine phosphatase, SixA
N2L00_01780	COG1511	domain protein
N2L00_01805	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
N2L00_01820	COG0514	ATP-dependent DNA helicase (RecQ)
N2L00_01835	COG1024	Enoyl-CoA hydratase
N2L00_01845	COG0667	Aldo Keto reductase
N2L00_01860	COG1505	serine-type exopeptidase activity
N2L00_01930	COG2072	flavoprotein involved in K transport
N2L00_01945	COG0604	alcohol dehydrogenase
N2L00_01950	COG1966	Carbon starvation protein
N2L00_01970	COG0656	L-ascorbic acid biosynthetic process
N2L00_01975	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
N2L00_02000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N2L00_02020	COG1815	bacterial-type flagellum-dependent cell motility
N2L00_02025	COG1558	bacterial-type flagellum-dependent cell motility
N2L00_02030	COG1677	Flagellar hook-basal body complex protein FliE
N2L00_02035	COG1766	The M ring may be actively involved in energy transduction
N2L00_02040	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N2L00_02050	COG1157	protein secretion by the type III secretion system
N2L00_02070	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
N2L00_02085	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N2L00_02090	COG1360	Flagellar Motor Protein
N2L00_02110	COG1338	Plays a role in the flagellum-specific transport system
N2L00_02115	COG1987	bacterial-type flagellum assembly
N2L00_02125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N2L00_02130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N2L00_02140	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N2L00_02160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N2L00_02165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N2L00_02170	COG0626	cystathionine gamma-synthase activity
N2L00_02185	COG0588	phosphoglycerate mutase activity
N2L00_02195	COG5002	protein histidine kinase activity
N2L00_02200	COG0745	RESPONSE REGULATOR receiver
N2L00_02215	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N2L00_02220	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N2L00_02225	COG0215	cysteine-tRNA ligase activity
N2L00_02230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N2L00_02245	COG0366	Alpha amylase catalytic
N2L00_02255	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N2L00_02300	COG0277	FAD linked oxidase domain protein
N2L00_02305	COG0366	Alpha amylase catalytic
N2L00_02320	COG3842	ATPase activity
N2L00_02365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N2L00_02375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N2L00_02380	COG0477	Major facilitator Superfamily
N2L00_02385	COG0477	Major facilitator Superfamily
N2L00_02390	COG1957	nucleoside hydrolase
N2L00_02400	COG0604	alcohol dehydrogenase
N2L00_02415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2L00_02420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2L00_02450	COG2159	amidohydrolase
N2L00_02490	COG2807	transmembrane transport
N2L00_02495	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_02505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N2L00_02505	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N2L00_02550	COG0667	Aldo Keto reductase
N2L00_02580	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N2L00_02600	COG0459	protein refolding
N2L00_02610	COG2205	protein histidine kinase activity
N2L00_02615	COG0745	RESPONSE REGULATOR receiver
N2L00_02660	COG1278	Cold shock
N2L00_02675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N2L00_02685	COG0739	heme binding
N2L00_02715	COG0303	'Molybdopterin
N2L00_02720	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N2L00_02725	COG5002	protein histidine kinase activity
N2L00_02730	COG1132	(ABC) transporter
N2L00_02750	COG1175	transmembrane transport
N2L00_02755	COG0395	ABC-type sugar transport system, permease component
N2L00_02785	COG0483	inositol monophosphate 1-phosphatase activity
N2L00_02795	COG0045	succinate-CoA ligase (ADP-forming) activity
N2L00_02805	COG2814	Major facilitator Superfamily
N2L00_02815	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N2L00_02840	COG0318	PFAM AMP-dependent synthetase and ligase
N2L00_02855	COG1396	sequence-specific DNA binding
N2L00_02870	COG0028	Belongs to the TPP enzyme family
N2L00_02890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N2L00_02945	COG3573	Dehydrogenase
N2L00_02975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N2L00_02980	COG0596	Alpha beta hydrolase
N2L00_02995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N2L00_03035	COG0640	Transcriptional regulator
N2L00_03040	COG0277	FAD linked oxidase domain protein
N2L00_03075	COG4213	ABC transporter substrate-binding protein
N2L00_03080	COG1129	ABC transporter
N2L00_03085	COG4214	carbohydrate transport
N2L00_03095	COG0673	inositol 2-dehydrogenase activity
N2L00_03100	COG1879	ABC-type sugar transport system periplasmic component
N2L00_03105	COG1129	ABC transporter
N2L00_03110	COG1172	Belongs to the binding-protein-dependent transport system permease family
N2L00_03115	COG1940	carbohydrate kinase activity
N2L00_03120	COG0583	DNA-binding transcription factor activity
N2L00_03140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2L00_03170	COG1074	ATP-dependent DNA helicase activity
N2L00_03175	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
N2L00_03230	COG2235	arginine
N2L00_03265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N2L00_03270	COG1802	Transcriptional regulator
N2L00_03275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N2L00_03340	COG1960	acyl-CoA dehydrogenase activity
N2L00_03345	COG0183	Belongs to the thiolase family
N2L00_03365	COG1358	cellular component organization or biogenesis
N2L00_03430	COG1595	DNA-templated transcription, initiation
N2L00_03460	COG1024	Enoyl-CoA hydratase
N2L00_03465	COG1250	3-hydroxyacyl-CoA dehydrogenase
N2L00_03485	COG2115	Belongs to the xylose isomerase family
N2L00_03490	COG1070	Carbohydrate kinase
N2L00_03495	COG2017	converts alpha-aldose to the beta-anomer
N2L00_03505	COG3458	cephalosporin-C deacetylase activity
N2L00_03510	COG1472	Belongs to the glycosyl hydrolase 3 family
N2L00_03525	COG1653	transport
N2L00_03530	COG1609	Transcriptional regulator
N2L00_03560	COG2814	Major facilitator Superfamily
N2L00_03565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N2L00_03575	COG0667	Aldo Keto reductase
N2L00_03585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N2L00_03605	COG0247	lactate metabolic process
N2L00_03610	COG1139	Iron-sulfur cluster binding protein
N2L00_03615	COG1556	Lactate utilization protein
N2L00_03625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N2L00_03635	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N2L00_03640	COG1620	l-lactate permease
N2L00_03645	COG3619	membrane
N2L00_03650	COG0405	Gamma-glutamyltransferase
N2L00_03655	COG1802	Transcriptional regulator
N2L00_03660	COG0039	L-malate dehydrogenase activity
N2L00_03665	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N2L00_03680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N2L00_03690	COG2323	membrane
N2L00_03695	COG1278	Cold shock
N2L00_03700	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
N2L00_03700	COG2066	Belongs to the glutaminase family
N2L00_03705	COG1278	Cold shock
N2L00_03715	COG0515	serine threonine protein kinase
N2L00_03715	COG2815	serine threonine protein kinase
N2L00_03720	COG3012	SEC-C Motif Domain Protein
N2L00_03725	COG1063	alcohol dehydrogenase
N2L00_03740	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
N2L00_03745	COG4133	protoheme IX ABC transporter activity
N2L00_03750	COG0829	nickel cation binding
N2L00_03755	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N2L00_03765	COG0804	urea catabolic process
N2L00_03775	COG0831	urea catabolic process
N2L00_03800	COG0753	catalase activity
N2L00_03860	COG0477	Major facilitator Superfamily
N2L00_03865	COG0138	bifunctional purine biosynthesis protein purh
N2L00_03875	COG0385	Bile acid
N2L00_03925	COG1172	Belongs to the binding-protein-dependent transport system permease family
N2L00_03930	COG1129	ABC transporter
N2L00_03960	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N2L00_03965	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N2L00_03970	COG1131	(ABC) transporter
N2L00_03995	COG0708	Exodeoxyribonuclease III
N2L00_04000	COG0180	Tryptophanyl-tRNA synthetase
N2L00_04015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N2L00_04030	COG2009	succinate dehydrogenase
N2L00_04040	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N2L00_04040	COG1473	amidohydrolase
N2L00_04045	COG1744	ABC transporter substrate-binding protein PnrA-like
N2L00_04050	COG3845	ABC transporter
N2L00_04055	COG4603	Belongs to the binding-protein-dependent transport system permease family
N2L00_04060	COG1079	Belongs to the binding-protein-dependent transport system permease family
N2L00_04080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N2L00_04085	COG3956	TIGRFAM MazG family protein
N2L00_04090	COG0148	phosphopyruvate hydratase activity
N2L00_04115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N2L00_04150	COG0559	Belongs to the binding-protein-dependent transport system permease family
N2L00_04165	COG2017	converts alpha-aldose to the beta-anomer
N2L00_04175	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N2L00_04180	COG0705	Rhomboid family
N2L00_04185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N2L00_04195	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N2L00_04205	COG1331	Highly conserved protein containing a thioredoxin domain
N2L00_04215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N2L00_04220	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N2L00_04235	COG0477	Major facilitator Superfamily
N2L00_04245	COG0114	fumarate hydratase activity
N2L00_04260	COG1494	fructose-1,6-bisphosphatase
N2L00_04275	COG0477	Major facilitator Superfamily
N2L00_04285	COG4569	acetaldehyde dehydrogenase (acetylating) activity
N2L00_04290	COG1414	Transcriptional regulator
N2L00_04300	COG1316	TRANSCRIPTIONal
N2L00_04305	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N2L00_04355	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N2L00_04405	COG0714	Associated with various cellular activities
N2L00_04410	COG0084	hydrolase, TatD family'
N2L00_04430	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N2L00_04435	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N2L00_04440	COG0488	(ABC) transporter
N2L00_04450	COG0577	efflux transmembrane transporter activity
N2L00_04450	COG1136	(ABC) transporter
N2L00_04475	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N2L00_04480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N2L00_04485	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N2L00_04490	COG0193	aminoacyl-tRNA hydrolase activity
N2L00_04520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N2L00_04525	COG0110	maltose O-acetyltransferase activity
N2L00_04555	COG0489	protein tyrosine kinase activity
N2L00_04590	COG0822	iron-sulfur transferase activity
N2L00_04595	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N2L00_04600	COG0297	glycogen (starch) synthase activity
N2L00_04605	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
N2L00_04610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N2L00_04615	COG5002	protein histidine kinase activity
N2L00_04625	COG5002	protein histidine kinase activity
N2L00_04670	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N2L00_04705	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N2L00_04735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N2L00_04750	COG0477	Major facilitator Superfamily
N2L00_04755	COG4770	biotin carboxylase activity
N2L00_04765	COG0424	maF-like protein
N2L00_04770	COG1823	symporter activity
N2L00_04785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N2L00_04815	COG0714	Associated with various cellular activities
N2L00_04830	COG0631	protein serine/threonine phosphatase activity
N2L00_04855	COG1674	ftsk spoiiie
N2L00_04905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N2L00_04910	COG0483	inositol monophosphate 1-phosphatase activity
N2L00_04940	COG0456	acetyltransferase
N2L00_04945	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N2L00_04950	COG0154	amidase activity
N2L00_04955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N2L00_04980	COG1254	Belongs to the acylphosphatase family
N2L00_04985	COG2986	histidine ammonia-lyase
N2L00_04990	COG1414	Transcriptional regulator
N2L00_04995	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N2L00_05010	COG1228	amidohydrolase
N2L00_05020	COG3250	beta-galactosidase activity
N2L00_05040	COG2873	o-acetylhomoserine
N2L00_05045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N2L00_05080	COG0423	glycine-tRNA ligase activity
N2L00_05095	COG2031	fatty acid transporter
N2L00_05115	COG0358	DNA primase activity
N2L00_05125	COG0494	nUDIX hydrolase
N2L00_05140	COG0477	Major facilitator Superfamily
N2L00_05160	COG0297	glycogen (starch) synthase activity
N2L00_05170	COG1960	acyl-CoA dehydrogenase activity
N2L00_05175	COG4942	peptidase
N2L00_05175	COG1388	LysM domain
N2L00_05180	COG0052	Belongs to the universal ribosomal protein uS2 family
N2L00_05185	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N2L00_05190	COG0528	UMP kinase activity
N2L00_05195	COG0233	cytoplasmic translational termination
N2L00_05200	COG0575	Belongs to the CDS family
N2L00_05210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N2L00_05225	COG3275	phosphorelay sensor kinase activity
N2L00_05235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N2L00_05250	COG0022	dehydrogenase e1 component
N2L00_05255	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2L00_05265	COG1309	transcriptional regulator
N2L00_05270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N2L00_05280	COG1960	acyl-CoA dehydrogenase activity
N2L00_05310	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N2L00_05315	COG0750	zinc metalloprotease
N2L00_05340	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N2L00_05365	COG0442	prolyl-tRNA aminoacylation
N2L00_05385	COG0779	Required for maturation of 30S ribosomal subunits
N2L00_05400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N2L00_05405	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N2L00_05410	COG0436	Aminotransferase
N2L00_05415	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N2L00_05440	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N2L00_05445	COG1185	polyribonucleotide nucleotidyltransferase activity
N2L00_05450	COG0612	Peptidase, M16
N2L00_05490	COG0521	Mo-molybdopterin cofactor biosynthetic process
N2L00_05500	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N2L00_05515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N2L00_05520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N2L00_05525	COG1674	ftsk spoiiie
N2L00_05535	COG1058	Belongs to the CinA family
N2L00_05535	COG1546	Belongs to the CinA family
N2L00_05540	COG1396	sequence-specific DNA binding
N2L00_05555	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N2L00_05560	COG2137	regulation of response to DNA damage stimulus
N2L00_05575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N2L00_05580	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N2L00_05585	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N2L00_05590	COG2813	Specifically methylates the guanine in position
N2L00_05595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N2L00_05605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N2L00_05615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N2L00_05620	COG0131	Imidazoleglycerol-phosphate dehydratase
N2L00_05625	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N2L00_05635	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N2L00_05655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N2L00_05660	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N2L00_05665	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N2L00_05670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N2L00_05680	COG2814	Major facilitator Superfamily
N2L00_05685	COG0494	nUDIX hydrolase
N2L00_05700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N2L00_05705	COG0072	phenylalanine-tRNA ligase activity
N2L00_05705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N2L00_05710	COG1011	Hydrolase
N2L00_05720	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N2L00_05725	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N2L00_05730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N2L00_05735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N2L00_05740	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N2L00_05745	COG1438	arginine binding
N2L00_05750	COG0137	argininosuccinate synthase activity
N2L00_05755	COG0165	Argininosuccinate lyase
N2L00_05760	COG0259	pyridoxamine-phosphate oxidase activity
N2L00_05770	COG2094	Belongs to the DNA glycosylase MPG family
N2L00_05780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N2L00_05790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N2L00_05815	COG0647	UMP catabolic process
N2L00_05830	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N2L00_05835	COG0497	DNA recombination
N2L00_05840	COG0504	CTP synthase activity
N2L00_05845	COG0494	nUDIX hydrolase
N2L00_05855	COG1051	belongs to the nudix hydrolase family
N2L00_05865	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N2L00_05870	COG2079	MmgE PrpD family protein
N2L00_05885	COG4565	transcriptional regulatory protein
N2L00_05890	COG3290	protein histidine kinase activity
N2L00_05895	COG1301	dicarboxylic acid transport
N2L00_05910	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N2L00_05915	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N2L00_05925	COG0287	Prephenate dehydrogenase
N2L00_05930	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N2L00_05935	COG1160	GTP binding
N2L00_05955	COG2197	response regulator
N2L00_05970	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_05975	COG2133	pyrroloquinoline quinone binding
N2L00_06000	COG1716	ATPase activity
N2L00_06025	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
N2L00_06040	COG1940	carbohydrate kinase activity
N2L00_06060	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
N2L00_06065	COG0515	serine threonine protein kinase
N2L00_06065	COG2815	serine threonine protein kinase
N2L00_06070	COG0741	lytic transglycosylase activity
N2L00_06080	COG0142	geranyltranstransferase activity
N2L00_06090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N2L00_06100	COG2001	Belongs to the MraZ family
N2L00_06105	COG0275	rRNA processing
N2L00_06115	COG0768	penicillin binding
N2L00_06120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N2L00_06130	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N2L00_06135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N2L00_06145	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N2L00_06150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N2L00_06160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N2L00_06165	COG1496	oxidoreductase activity
N2L00_06175	COG1799	cell septum assembly
N2L00_06185	COG3599	regulation of cell shape
N2L00_06190	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N2L00_06200	COG0587	DNA-directed DNA polymerase activity
N2L00_06205	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N2L00_06210	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N2L00_06230	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N2L00_06235	COG0174	glutamine synthetase
N2L00_06240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N2L00_06245	COG0765	amino acid transport
N2L00_06250	COG1126	abc transporter atp-binding protein
N2L00_06260	COG0657	acetylesterase activity
N2L00_06300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N2L00_06305	COG0321	lipoyl(octanoyl) transferase activity
N2L00_06315	COG0793	Belongs to the peptidase S41A family
N2L00_06315	COG4946	Tricorn protease homolog
N2L00_06320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N2L00_06325	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N2L00_06335	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
N2L00_06340	COG0829	nickel cation binding
N2L00_06345	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N2L00_06350	COG0830	nickel cation binding
N2L00_06355	COG0804	urea catabolic process
N2L00_06360	COG0832	Belongs to the urease beta subunit family
N2L00_06370	COG0831	urea catabolic process
N2L00_06375	COG1764	response to oxidative stress
N2L00_06385	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2L00_06390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N2L00_06395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N2L00_06410	COG1131	(ABC) transporter
N2L00_06425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N2L00_06435	COG0187	DNA topoisomerase II activity
N2L00_06440	COG0501	Belongs to the peptidase M48B family
N2L00_06450	COG1271	oxidase subunit
N2L00_06455	COG1294	oxidase, subunit
N2L00_06460	COG4988	ABC transporter
N2L00_06465	COG0454	-acetyltransferase
N2L00_06465	COG0456	acetyltransferase
N2L00_06475	COG1937	Protein conserved in bacteria
N2L00_06490	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N2L00_06505	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
N2L00_06510	COG1435	thymidine kinase activity
N2L00_06530	COG0756	dUTP diphosphatase activity
N2L00_06555	COG0569	domain protein
N2L00_06560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N2L00_06565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N2L00_06570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N2L00_06585	COG0667	Aldo Keto reductase
N2L00_06595	COG1024	Enoyl-CoA hydratase
N2L00_06595	COG1250	3-hydroxyacyl-CoA dehydrogenase
N2L00_06600	COG0183	Belongs to the thiolase family
N2L00_06615	COG0657	acetylesterase activity
N2L00_06655	COG0737	Belongs to the 5'-nucleotidase family
N2L00_06670	COG2318	DinB family
N2L00_06725	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N2L00_06730	COG2814	Major facilitator Superfamily
N2L00_06740	COG0183	Belongs to the thiolase family
N2L00_06755	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
N2L00_06760	COG4989	oxidoreductase activity
N2L00_06770	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
N2L00_06775	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
N2L00_06795	COG1269	ATP hydrolysis coupled proton transport
N2L00_06820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N2L00_06840	COG0500	methyltransferase
N2L00_06845	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N2L00_06895	COG1309	transcriptional regulator
N2L00_06900	COG0477	Major facilitator Superfamily
N2L00_06910	COG0702	epimerase
N2L00_06980	COG0242	peptide deformylase activity
N2L00_06985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N2L00_06995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N2L00_07010	COG4335	DNA alkylation repair
N2L00_07015	COG0477	Major facilitator Superfamily
N2L00_07025	COG0640	Transcriptional regulator
N2L00_07030	COG0798	PFAM Bile acid sodium symporter
N2L00_07035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N2L00_07050	COG2076	Multidrug Resistance protein
N2L00_07055	COG0667	Aldo Keto reductase
N2L00_07065	COG1131	(ABC) transporter
N2L00_07070	COG1476	TRANSCRIPTIONal
N2L00_07080	COG1595	DNA-templated transcription, initiation
N2L00_07095	COG1942	4-Oxalocrotonate Tautomerase
N2L00_07100	COG0456	acetyltransferase
N2L00_07155	COG1064	alcohol dehydrogenase
N2L00_07205	COG3655	Transcriptional regulator
N2L00_07220	COG1609	Transcriptional regulator
N2L00_07225	COG1063	alcohol dehydrogenase
N2L00_07230	COG1129	ABC transporter
N2L00_07235	COG1172	Belongs to the binding-protein-dependent transport system permease family
N2L00_07240	COG1879	ABC-type sugar transport system periplasmic component
N2L00_07245	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_07250	COG4941	Belongs to the sigma-70 factor family
N2L00_07275	COG1175	transmembrane transport
N2L00_07280	COG3833	ABC-type maltose transport systems, permease component
N2L00_07295	COG0140	phosphoribosyl-ATP diphosphatase activity
N2L00_07300	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N2L00_07305	COG0107	imidazoleglycerol-phosphate synthase activity
N2L00_07325	COG1064	alcohol dehydrogenase
N2L00_07330	COG2354	Protein conserved in bacteria
N2L00_07345	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N2L00_07365	COG0134	indole-3-glycerol-phosphate synthase activity
N2L00_07370	COG0133	tryptophan synthase activity
N2L00_07375	COG0159	tryptophan synthase activity
N2L00_07380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N2L00_07385	COG0067	glutamate synthase
N2L00_07385	COG0069	glutamate synthase activity
N2L00_07385	COG0070	glutamate synthase
N2L00_07435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N2L00_07450	COG3962	Belongs to the TPP enzyme family
N2L00_07460	COG1082	Xylose isomerase domain protein TIM barrel
N2L00_07465	COG0673	inositol 2-dehydrogenase activity
N2L00_07470	COG1082	Xylose isomerase domain protein TIM barrel
N2L00_07475	COG2814	Major facilitator Superfamily
N2L00_07480	COG3718	enzyme involved in inositol metabolism
N2L00_07490	COG1879	ABC-type sugar transport system periplasmic component
N2L00_07495	COG1172	Belongs to the binding-protein-dependent transport system permease family
N2L00_07505	COG0673	inositol 2-dehydrogenase activity
N2L00_07575	COG1595	DNA-templated transcription, initiation
N2L00_07600	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N2L00_07605	COG0778	Nitroreductase
N2L00_07610	COG1329	Transcriptional regulator
N2L00_07615	COG1643	Atp-dependent helicase
N2L00_07640	COG2814	Major facilitator Superfamily
N2L00_07650	COG1960	acyl-CoA dehydrogenase activity
N2L00_07685	COG0488	(ABC) transporter
N2L00_07705	COG1785	Belongs to the alkaline phosphatase family
N2L00_07710	COG0009	L-threonylcarbamoyladenylate synthase
N2L00_07725	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N2L00_07730	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N2L00_07740	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_07760	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
N2L00_07765	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
N2L00_07770	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
N2L00_07785	COG3103	Sh3 type 3 domain protein
N2L00_07785	COG1388	LysM domain
N2L00_07785	COG0791	NLP P60 protein
N2L00_07800	COG1136	(ABC) transporter
N2L00_07810	COG4585	Histidine kinase
N2L00_07820	COG0425	Belongs to the sulfur carrier protein TusA family
N2L00_07825	COG2391	methyltransferase activity
N2L00_07830	COG1215	transferase activity, transferring glycosyl groups
N2L00_07850	COG2272	Belongs to the type-B carboxylesterase lipase family
N2L00_07860	COG0488	(ABC) transporter
N2L00_07865	COG2272	Belongs to the type-B carboxylesterase lipase family
N2L00_07885	COG1607	acyl-coa hydrolase
N2L00_07890	COG0438	transferase activity, transferring glycosyl groups
N2L00_07900	COG1216	Glycosyl transferase, family 2
N2L00_07910	COG1472	Belongs to the glycosyl hydrolase 3 family
N2L00_07915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N2L00_07920	COG0477	Major facilitator Superfamily
N2L00_07925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N2L00_07930	COG3185	4-Hydroxyphenylpyruvate dioxygenase
N2L00_07930	COG1082	Xylose isomerase domain protein TIM barrel
N2L00_07935	COG1414	Transcriptional regulator
N2L00_07945	COG0531	amino acid
N2L00_07950	COG0076	glutamate decarboxylase activity
N2L00_07960	COG2814	Major facilitator Superfamily
N2L00_07975	COG1902	pentaerythritol trinitrate reductase activity
N2L00_07985	COG2050	protein possibly involved in aromatic compounds catabolism
N2L00_07995	COG4552	Acetyltransferase involved in intracellular survival and related
N2L00_08000	COG0539	negative regulation of cytoplasmic translation
N2L00_08015	COG2723	6-phospho-beta-galactosidase activity
N2L00_08025	COG1175	transmembrane transport
N2L00_08035	COG2813	Specifically methylates the guanine in position
N2L00_08040	COG1739	Uncharacterized protein family UPF0029
N2L00_08045	COG0237	dephospho-CoA kinase activity
N2L00_08045	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N2L00_08050	COG0556	nucleotide-excision repair
N2L00_08090	COG4106	trans-aconitate 2-methyltransferase activity
N2L00_08130	COG0322	excinuclease ABC activity
N2L00_08135	COG1660	Displays ATPase and GTPase activities
N2L00_08145	COG1481	regulation of sporulation
N2L00_08160	COG0126	phosphoglycerate kinase activity
N2L00_08165	COG0149	triose-phosphate isomerase activity
N2L00_08170	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N2L00_08175	COG0363	glucosamine-6-phosphate deaminase activity
N2L00_08195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N2L00_08205	COG0109	protoheme IX farnesyltransferase activity
N2L00_08210	COG1612	heme a metabolic process
N2L00_08220	COG1131	(ABC) transporter
N2L00_08240	COG0396	ATPase activity
N2L00_08245	COG2151	metal-sulfur cluster biosynthetic enzyme
N2L00_08275	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N2L00_08280	COG1122	ATPase activity
N2L00_08285	COG1268	BioY protein
N2L00_08290	COG0488	(ABC) transporter
N2L00_08315	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_08320	COG0560	Phosphoserine phosphatase
N2L00_08320	COG3830	Belongs to the UPF0237 family
N2L00_08325	COG1119	ATPase activity
N2L00_08340	COG0254	rRNA binding
N2L00_08365	COG2855	membrane
N2L00_08370	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N2L00_08385	COG0297	glycogen (starch) synthase activity
N2L00_08400	COG0183	Belongs to the thiolase family
N2L00_08405	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_08420	COG0589	response to stress
N2L00_08425	COG0531	amino acid
N2L00_08430	COG1253	flavin adenine dinucleotide binding
N2L00_08440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N2L00_08460	COG1968	undecaprenyl-diphosphatase activity
N2L00_08465	COG0215	cysteine-tRNA ligase activity
N2L00_08475	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N2L00_08480	COG0517	IMP dehydrogenase activity
N2L00_08480	COG1994	Peptidase M50
N2L00_08495	COG4122	O-methyltransferase activity
N2L00_08505	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N2L00_08510	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N2L00_08515	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N2L00_08520	COG0545	Peptidyl-prolyl cis-trans isomerase
N2L00_08540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N2L00_08545	COG0805	protein transport
N2L00_08550	COG4581	dead DEAH box helicase
N2L00_08555	COG1574	metal-dependent hydrolase with the TIM-barrel fold
N2L00_08560	COG1216	Glycosyl transferase, family 2
N2L00_08585	COG0823	Involved in the tonB-independent uptake of proteins
N2L00_08585	COG1506	peptidase
N2L00_08585	COG4946	Tricorn protease homolog
N2L00_08590	COG0242	peptide deformylase activity
N2L00_08630	COG4941	Belongs to the sigma-70 factor family
N2L00_08635	COG0366	Alpha amylase catalytic
N2L00_08675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N2L00_08680	COG1845	cytochrome c oxidase, subunit III
N2L00_08685	COG2010	Cytochrome c
N2L00_08690	COG0723	plastoquinol--plastocyanin reductase activity
N2L00_08695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N2L00_08705	COG2188	Transcriptional regulator
N2L00_08715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N2L00_08720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N2L00_08740	COG0167	dihydroorotate dehydrogenase activity
N2L00_08750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N2L00_08755	COG1381	Involved in DNA repair and RecF pathway recombination
N2L00_08760	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N2L00_08765	COG1316	TRANSCRIPTIONal
N2L00_08770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N2L00_08780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N2L00_08800	COG0484	heat shock protein binding
N2L00_08805	COG1420	regulation of RNA biosynthetic process
N2L00_08825	COG0481	GTPase activity
N2L00_08835	COG0268	Binds directly to 16S ribosomal RNA
N2L00_08860	COG1307	EDD domain protein, DegV family
N2L00_08865	COG0495	leucyl-tRNA aminoacylation
N2L00_08875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N2L00_08880	COG0385	Bile acid
N2L00_08885	COG2072	flavoprotein involved in K transport
N2L00_08890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N2L00_08895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N2L00_08900	COG0656	L-ascorbic acid biosynthetic process
N2L00_08910	COG0438	transferase activity, transferring glycosyl groups
N2L00_08915	COG2130	NADP-dependent
N2L00_08920	COG1846	Transcriptional regulator
N2L00_08930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N2L00_08950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N2L00_08960	COG1758	RNA polymerase activity
N2L00_08965	COG0194	GDP metabolic process
N2L00_08970	COG0194	GDP metabolic process
N2L00_08975	COG0284	orotidine-5'-phosphate decarboxylase activity
N2L00_08980	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N2L00_08985	COG0505	Belongs to the CarA family
N2L00_08995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N2L00_09000	COG0540	Belongs to the ATCase OTCase family
N2L00_09005	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N2L00_09015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N2L00_09020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N2L00_09025	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N2L00_09035	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N2L00_09040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N2L00_09050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N2L00_09055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N2L00_09070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N2L00_09090	COG0384	phenazine biosynthesis protein PhzF
N2L00_09095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N2L00_09105	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N2L00_09120	COG2197	response regulator
N2L00_09125	COG0124	histidyl-tRNA synthetase
N2L00_09135	COG1196	nuclear chromosome segregation
N2L00_09145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N2L00_09150	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N2L00_09155	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N2L00_09165	COG2255	four-way junction helicase activity
N2L00_09170	COG0632	four-way junction helicase activity
N2L00_09175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N2L00_09180	COG0217	transcriptional regulatory protein
N2L00_09185	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N2L00_09210	COG0339	signal peptide processing
N2L00_09215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N2L00_09225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N2L00_09230	COG0587	DNA-directed DNA polymerase activity
N2L00_09260	COG2365	Tyrosine phosphatase family
N2L00_09285	COG2135	peptidase activity
N2L00_09325	COG0346	lactoylglutathione lyase activity
N2L00_09370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N2L00_09400	COG0667	Aldo Keto reductase
N2L00_09405	COG2135	peptidase activity
N2L00_09420	COG0656	L-ascorbic acid biosynthetic process
N2L00_09455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N2L00_09470	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_09515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N2L00_09530	COG1131	(ABC) transporter
N2L00_09535	COG2318	DinB family
N2L00_09550	COG0443	Heat shock 70 kDa protein
N2L00_09565	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N2L00_09570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N2L00_09575	COG1780	Probably involved in ribonucleotide reductase function
N2L00_09655	COG0588	phosphoglycerate mutase activity
N2L00_09670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N2L00_09680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N2L00_09685	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N2L00_09690	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N2L00_09695	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N2L00_09700	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N2L00_09705	COG1530	ribonuclease E activity
N2L00_09725	COG0105	UTP biosynthetic process
N2L00_09735	COG0285	dihydrofolate synthase activity
N2L00_09740	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N2L00_09755	COG0525	valine-tRNA ligase activity
N2L00_09760	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N2L00_09765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N2L00_09770	COG0740	serine-type endopeptidase activity
N2L00_09780	COG0544	peptidyl-prolyl cis-trans isomerase activity
N2L00_09800	COG0698	ribose 5-phosphate isomerase
N2L00_09820	COG0668	transmembrane transport
N2L00_09840	COG1946	Acyl-CoA thioesterase
N2L00_09855	COG0629	single-stranded DNA binding
N2L00_09925	COG0242	peptide deformylase activity
N2L00_09945	COG3022	response to hydroperoxide
N2L00_09955	COG1579	Zn-ribbon protein possibly nucleic acid-binding
N2L00_09960	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N2L00_09965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N2L00_09975	COG1045	serine acetyltransferase
N2L00_09980	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N2L00_10010	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N2L00_10030	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N2L00_10035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N2L00_10050	COG4974	Belongs to the 'phage' integrase family
N2L00_10070	COG0792	nuclease activity
N2L00_10075	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_10105	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N2L00_10110	COG0681	Belongs to the peptidase S26 family
N2L00_10115	COG0681	Belongs to the peptidase S26 family
N2L00_10120	COG0335	large ribosomal subunit rRNA binding
N2L00_10125	COG0336	Belongs to the RNA methyltransferase TrmD family
N2L00_10130	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N2L00_10135	COG1837	Belongs to the UPF0109 family
N2L00_10140	COG0228	four-way junction DNA binding
N2L00_10145	COG2514	catechol 2,3-dioxygenase activity
N2L00_10185	COG0552	protein localization to endoplasmic reticulum
N2L00_10190	COG0477	Major facilitator Superfamily
N2L00_10200	COG1196	nuclear chromosome segregation
N2L00_10205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N2L00_10210	COG0318	PFAM AMP-dependent synthetase and ligase
N2L00_10215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N2L00_10235	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N2L00_10250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N2L00_10255	COG0571	ribonuclease III activity
N2L00_10260	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N2L00_10270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N2L00_10285	COG0742	ribosomal rna small subunit methyltransferase
N2L00_10295	COG1461	Dihydroxyacetone kinase
N2L00_10300	COG1316	TRANSCRIPTIONal
N2L00_10310	COG1181	Belongs to the D-alanine--D-alanine ligase family
N2L00_10315	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N2L00_10325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N2L00_10330	COG0066	3-isopropylmalate dehydratase activity
N2L00_10335	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N2L00_10340	COG1414	Transcriptional regulator
N2L00_10370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N2L00_10380	COG0179	Fumarylacetoacetate (FAA) hydrolase
N2L00_10405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N2L00_10410	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N2L00_10415	COG0473	3-isopropylmalate dehydrogenase activity
N2L00_10420	COG4585	Histidine kinase
N2L00_10425	COG2197	response regulator
N2L00_10460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N2L00_10465	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N2L00_10470	COG0440	acetolactate synthase activity
N2L00_10480	COG0129	dihydroxy-acid dehydratase activity
N2L00_10515	COG1690	Belongs to the RtcB family
N2L00_10535	COG0747	negative chemotaxis
N2L00_10540	COG0601	transmembrane transport
N2L00_10545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N2L00_10555	COG4172	Belongs to the ABC transporter superfamily
N2L00_10560	COG0747	negative chemotaxis
N2L00_10565	COG0579	oxidoreductase
N2L00_10570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N2L00_10590	COG2814	Major facilitator Superfamily
N2L00_10595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N2L00_10600	COG1522	sequence-specific DNA binding
N2L00_10605	COG1113	amino acid transport
N2L00_10615	COG0022	dehydrogenase e1 component
N2L00_10620	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2L00_10630	COG0515	serine threonine protein kinase
N2L00_10645	COG0419	ATPase involved in DNA repair
N2L00_10650	COG0420	3'-5' exonuclease activity
N2L00_10655	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N2L00_10670	COG0586	Pfam SNARE associated Golgi protein
N2L00_10675	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N2L00_10680	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N2L00_10695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N2L00_10705	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N2L00_10715	COG1335	isochorismatase
N2L00_10740	COG1902	pentaerythritol trinitrate reductase activity
N2L00_10765	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
N2L00_10780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N2L00_10790	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N2L00_10795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N2L00_10800	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N2L00_10805	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N2L00_10810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N2L00_10815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N2L00_10820	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N2L00_10825	COG0356	it plays a direct role in the translocation of protons across the membrane
N2L00_10845	COG1086	Polysaccharide biosynthesis protein
N2L00_10870	COG2890	protein-(glutamine-N5) methyltransferase activity
N2L00_10875	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N2L00_10885	COG0083	homoserine kinase activity
N2L00_10890	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N2L00_10895	COG0460	homoserine dehydrogenase
N2L00_10905	COG0018	arginyl-trna synthetase
N2L00_10920	COG0543	2 iron, 2 sulfur cluster binding
N2L00_10920	COG0633	Ferredoxin
N2L00_10960	COG0559	Belongs to the binding-protein-dependent transport system permease family
N2L00_10990	COG1643	Atp-dependent helicase
N2L00_10995	COG0537	adenosine 5'-monophosphoramidase activity
N2L00_11005	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N2L00_11020	COG1121	(ABC) transporter
N2L00_11035	COG1253	flavin adenine dinucleotide binding
N2L00_11040	COG0567	Dehydrogenase, E1 component
N2L00_11040	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2L00_11060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N2L00_11065	COG4172	Belongs to the ABC transporter superfamily
N2L00_11075	COG1024	Enoyl-CoA hydratase
N2L00_11085	COG1024	Enoyl-CoA hydratase
N2L00_11095	COG1960	acyl-CoA dehydrogenase activity
N2L00_11105	COG1595	DNA-templated transcription, initiation
N2L00_11115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N2L00_11125	COG0483	inositol monophosphate 1-phosphatase activity
N2L00_11135	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N2L00_11140	COG0366	Alpha amylase catalytic
N2L00_11170	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N2L00_11175	COG0741	lytic transglycosylase activity
N2L00_11175	COG0739	heme binding
N2L00_11175	COG1196	nuclear chromosome segregation
N2L00_11180	COG2177	Part of the ABC transporter FtsEX involved in
N2L00_11185	COG2884	Cell division ATP-binding protein ftsE
N2L00_11190	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N2L00_11265	COG1086	Polysaccharide biosynthesis protein
N2L00_11270	COG1216	Glycosyl transferase, family 2
N2L00_11305	COG1216	Glycosyl transferase, family 2
N2L00_11315	COG2755	lipolytic protein G-D-S-L family
N2L00_11315	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N2L00_11320	COG1674	ftsk spoiiie
N2L00_11340	COG2902	Dehydrogenase
N2L00_11375	COG0653	protein targeting
N2L00_11380	COG3214	Protein conserved in bacteria
N2L00_11385	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N2L00_11395	COG5401	PFAM Sporulation and spore germination
N2L00_11400	COG5002	protein histidine kinase activity
N2L00_11405	COG0745	RESPONSE REGULATOR receiver
N2L00_11425	COG0714	Associated with various cellular activities
N2L00_11450	COG0482	sulfurtransferase activity
N2L00_11465	COG0596	Alpha beta hydrolase
N2L00_11470	COG0484	heat shock protein binding
N2L00_11475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N2L00_11490	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
N2L00_11500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N2L00_11510	COG1842	Phage shock protein A
N2L00_11525	COG1615	UPF0182 protein
N2L00_11530	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N2L00_11570	COG1131	(ABC) transporter
N2L00_11580	COG0210	DNA helicase
N2L00_11605	COG2011	ABC-type metal ion transport system permease component
N2L00_11615	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N2L00_11620	COG0113	porphobilinogen synthase activity
N2L00_11630	COG0181	hydroxymethylbilane synthase activity
N2L00_11635	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N2L00_11640	COG3253	May function as heme-dependent peroxidase
N2L00_11650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N2L00_11655	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N2L00_11700	COG0613	PHP domain protein
N2L00_11705	COG0006	proline dipeptidase activity
N2L00_11715	COG2239	Acts as a magnesium transporter
N2L00_11730	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N2L00_11740	COG1595	DNA-templated transcription, initiation
N2L00_11750	COG0024	Methionine aminopeptidase
N2L00_11755	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N2L00_11770	COG0519	Catalyzes the synthesis of GMP from XMP
N2L00_11780	COG1611	Belongs to the LOG family
N2L00_11785	COG1126	abc transporter atp-binding protein
N2L00_11790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N2L00_11795	COG0765	amino acid transport
N2L00_11800	COG0765	amino acid transport
N2L00_11805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N2L00_11810	COG2171	N-acyltransferase activity
N2L00_11820	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N2L00_11850	COG1217	gtp-binding protein TYPA
N2L00_11860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N2L00_11865	COG0601	transmembrane transport
N2L00_11905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N2L00_11935	COG0012	GTP binding
N2L00_11940	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N2L00_11950	COG1570	exodeoxyribonuclease VII activity
N2L00_11955	COG1722	exodeoxyribonuclease VII activity
N2L00_11975	COG1174	glycine betaine transport
N2L00_11985	COG0494	nUDIX hydrolase
N2L00_11990	COG2971	BadF BadG BcrA BcrD
N2L00_12020	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N2L00_12025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N2L00_12045	COG0519	Catalyzes the synthesis of GMP from XMP
N2L00_12045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N2L00_12065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N2L00_12070	COG0516	GMP reductase activity
N2L00_12080	COG0459	protein refolding
N2L00_12085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N2L00_12095	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2L00_12100	COG4605	iron ion homeostasis
N2L00_12105	COG4604	ABC transporter, ATP-binding protein
N2L00_12125	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N2L00_12135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N2L00_12140	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N2L00_12145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N2L00_12150	COG1247	-acetyltransferase
N2L00_12160	COG0802	atpase or kinase
N2L00_12165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N2L00_12175	COG0667	Aldo Keto reductase
N2L00_12200	COG0736	holo-[acyl-carrier-protein] synthase activity
N2L00_12210	COG1072	(Pantothenic acid kinase))
N2L00_12215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N2L00_12220	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N2L00_12225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N2L00_12230	COG0101	tRNA pseudouridine synthase activity
N2L00_12235	COG0203	ribosomal protein L17
N2L00_12240	COG0202	RNA polymerase activity
N2L00_12245	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N2L00_12250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N2L00_12255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N2L00_12260	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N2L00_12265	COG0584	glycerophosphoryl diester phosphodiesterase
N2L00_12270	COG0024	Methionine aminopeptidase
N2L00_12275	COG0563	adenylate kinase activity
N2L00_12285	COG0200	Binds to the 23S rRNA
N2L00_12290	COG1841	ribosomal large subunit assembly
N2L00_12295	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N2L00_12305	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N2L00_12310	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N2L00_12315	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N2L00_12320	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N2L00_12325	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N2L00_12330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N2L00_12340	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N2L00_12345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N2L00_12350	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N2L00_12355	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N2L00_12360	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N2L00_12365	COG0089	rRNA binding
N2L00_12370	COG0088	Forms part of the polypeptide exit tunnel
N2L00_12375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N2L00_12380	COG0051	transcription antitermination factor activity, RNA binding
N2L00_12395	COG0318	PFAM AMP-dependent synthetase and ligase
N2L00_12405	COG0446	pyridine nucleotide-disulphide oxidoreductase
N2L00_12405	COG1902	pentaerythritol trinitrate reductase activity
N2L00_12410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N2L00_12415	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N2L00_12420	COG0049	tRNA binding
N2L00_12425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N2L00_12430	COG1414	Transcriptional regulator
N2L00_12435	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N2L00_12445	COG0183	Belongs to the thiolase family
N2L00_12450	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N2L00_12465	COG3485	protocatechuate 3,4-dioxygenase
N2L00_12470	COG3485	protocatechuate 3,4-dioxygenase
N2L00_12490	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N2L00_12495	COG0085	RNA polymerase activity
N2L00_12505	COG0222	ribosome binding
N2L00_12510	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N2L00_12520	COG0081	regulation of translation
N2L00_12525	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N2L00_12545	COG0436	Aminotransferase
N2L00_12550	COG2197	response regulator
N2L00_12595	COG3485	protocatechuate 3,4-dioxygenase
N2L00_12605	COG0745	RESPONSE REGULATOR receiver
N2L00_12610	COG0456	acetyltransferase
N2L00_12615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N2L00_12625	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N2L00_12630	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N2L00_12635	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N2L00_12645	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N2L00_12655	COG2030	dehydratase
N2L00_12670	COG0693	protein deglycase activity
N2L00_12685	COG0515	serine threonine protein kinase
N2L00_12685	COG2815	serine threonine protein kinase
N2L00_12700	COG5650	phosphatidylinositol metabolic process
N2L00_12705	COG1228	amidohydrolase
N2L00_12740	COG1063	alcohol dehydrogenase
N2L00_12745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N2L00_12765	COG1666	GTP binding
N2L00_12770	COG0406	alpha-ribazole phosphatase activity
N2L00_12775	COG0501	Belongs to the peptidase M48B family
N2L00_12785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N2L00_12825	COG1233	COG1233 Phytoene dehydrogenase and related
N2L00_12835	COG0142	geranyltranstransferase activity
N2L00_12840	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
N2L00_12845	COG0463	Glycosyl transferase, family 2
N2L00_12920	COG1012	belongs to the aldehyde dehydrogenase family
N2L00_12945	COG0142	geranyltranstransferase activity
N2L00_12955	COG2226	methyltransferase
N2L00_12970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N2L00_12975	COG0765	amino acid transport
N2L00_12985	COG0583	DNA-binding transcription factor activity
N2L00_12990	COG0477	Major facilitator Superfamily
N2L00_13000	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
N2L00_13005	COG0473	3-isopropylmalate dehydrogenase activity
N2L00_13010	COG0471	metal ion transport
N2L00_13015	COG4948	Mandelate Racemase Muconate Lactonizing
N2L00_13040	COG0022	dehydrogenase e1 component
N2L00_13050	COG1522	sequence-specific DNA binding
N2L00_13060	COG1024	Enoyl-CoA hydratase
N2L00_13065	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N2L00_13070	COG2151	metal-sulfur cluster biosynthetic enzyme
N2L00_13075	COG3396	Phenylacetate-CoA oxygenase
N2L00_13080	COG3460	Phenylacetate-CoA oxygenase
N2L00_13085	COG3396	Phenylacetate-CoA oxygenase
N2L00_13105	COG2723	6-phospho-beta-galactosidase activity
N2L00_13110	COG0395	ABC-type sugar transport system, permease component
N2L00_13125	COG0586	Pfam SNARE associated Golgi protein
N2L00_13155	COG1012	belongs to the aldehyde dehydrogenase family
N2L00_13155	COG2030	dehydratase
N2L00_13170	COG1793	dna ligase
N2L00_13180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N2L00_13200	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N2L00_13225	COG1140	nitrate reductase beta subunit
N2L00_13235	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
N2L00_13260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N2L00_13270	COG0785	Cytochrome C biogenesis protein
N2L00_13280	COG0406	alpha-ribazole phosphatase activity
N2L00_13300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
N2L00_13325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N2L00_13330	COG0640	Transcriptional regulator
N2L00_13335	COG0123	including yeast histone deacetylase and acetoin utilization protein
N2L00_13340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N2L00_13345	COG0569	domain protein
N2L00_13355	COG1082	Xylose isomerase domain protein TIM barrel
N2L00_13360	COG0248	Ppx GppA phosphatase
N2L00_13365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N2L00_13365	COG1754	DNA topoisomerase type I activity
N2L00_13370	COG2890	protein-(glutamine-N5) methyltransferase activity
N2L00_13375	COG1053	succinate dehydrogenase
N2L00_13380	COG1054	Belongs to the UPF0176 family
N2L00_13390	COG1111	helicase
N2L00_13390	COG1205	dead DEAH box helicase
N2L00_13520	COG2072	flavoprotein involved in K transport
N2L00_13530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N2L00_13530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N2L00_13540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N2L00_13550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N2L00_13555	COG1764	response to oxidative stress
N2L00_13565	COG0477	Major facilitator Superfamily
N2L00_13570	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N2L00_13600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N2L00_13605	COG1408	metallophosphoesterase
N2L00_13615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N2L00_13620	COG0151	Belongs to the GarS family
N2L00_13645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N2L00_13660	COG0542	response to heat
N2L00_13675	COG3304	Inner membrane component domain
N2L00_13690	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N2L00_13715	COG0789	Transcriptional regulator
N2L00_13720	COG0484	heat shock protein binding
N2L00_13725	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N2L00_13730	COG0443	Heat shock 70 kDa protein
N2L00_13745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N2L00_13760	COG1122	ATPase activity
N2L00_13780	COG2212	antiporter activity
N2L00_13785	COG1863	multisubunit Na H antiporter MnhE subunit
N2L00_13790	COG0651	ATP synthesis coupled electron transport
N2L00_13795	COG1006	Multisubunit Na H antiporter MnhC subunit
N2L00_13800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N2L00_13800	COG2111	Na H antiporter
N2L00_13810	COG0717	Belongs to the dCTP deaminase family
N2L00_13815	COG3483	tryptophan 2,3-dioxygenase activity
N2L00_13840	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
N2L00_13880	COG3336	cytochrome c oxidase
N2L00_13885	COG0776	regulation of translation
N2L00_13890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N2L00_13895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N2L00_13900	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N2L00_13905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N2L00_13915	COG0477	Major facilitator Superfamily
N2L00_13925	COG1597	lipid kinase activity
N2L00_13930	COG1196	nuclear chromosome segregation
N2L00_13930	COG0739	heme binding
N2L00_13930	COG0741	lytic transglycosylase activity
N2L00_13935	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2L00_13940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2L00_13955	COG1120	ATPase activity
N2L00_13960	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2L00_13965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2L00_13970	COG0435	Glutathione S-transferase
N2L00_13985	COG0531	amino acid
N2L00_13990	COG1309	transcriptional regulator
N2L00_14000	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N2L00_14005	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N2L00_14015	COG1295	ribonuclease BN
N2L00_14040	COG2146	nitrite reductase [NAD(P)H] activity
N2L00_14065	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_14070	COG1960	acyl-CoA dehydrogenase activity
N2L00_14105	COG1414	Transcriptional regulator
N2L00_14110	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N2L00_14120	COG1063	alcohol dehydrogenase
N2L00_14140	COG1174	glycine betaine transport
N2L00_14150	COG1174	glycine betaine transport
N2L00_14185	COG1473	amidohydrolase
N2L00_14200	COG4152	abc transporter atp-binding protein
N2L00_14235	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_14240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N2L00_14245	COG1012	belongs to the aldehyde dehydrogenase family
N2L00_14265	COG0318	PFAM AMP-dependent synthetase and ligase
N2L00_14275	COG4221	oxidoreductase activity
N2L00_14310	COG0028	Belongs to the TPP enzyme family
N2L00_14345	COG0596	Alpha beta hydrolase
N2L00_14350	COG5002	protein histidine kinase activity
N2L00_14370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2L00_14380	COG1012	belongs to the aldehyde dehydrogenase family
N2L00_14385	COG2860	membrane
N2L00_14395	COG1063	alcohol dehydrogenase
N2L00_14415	COG3386	PFAM SMP-30 Gluconolaconase
N2L00_14425	COG2610	gluconate transmembrane transporter activity
N2L00_14430	COG0531	amino acid
N2L00_14460	COG0492	ferredoxin-NADP+ reductase activity
N2L00_14530	COG1414	Transcriptional regulator
N2L00_14535	COG2217	Heavy metal translocating P-type atpase
N2L00_14540	COG0598	Magnesium transport protein CorA
N2L00_14550	COG0477	Major facilitator Superfamily
N2L00_14560	COG3546	catalase activity
N2L00_14570	COG0500	methyltransferase
N2L00_14585	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_14595	COG0477	Major facilitator Superfamily
N2L00_14605	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N2L00_14615	COG2301	Belongs to the HpcH HpaI aldolase family
N2L00_14620	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N2L00_14630	COG3257	ureidoglycine aminohydrolase activity
N2L00_14640	COG2233	PERMEase
N2L00_14665	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
N2L00_14665	COG3608	succinylglutamate desuccinylase aspartoacylase
N2L00_14675	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N2L00_14685	COG0697	spore germination
N2L00_14690	COG1846	Transcriptional regulator
N2L00_14715	COG5650	phosphatidylinositol metabolic process
N2L00_14725	COG0179	Fumarylacetoacetate (FAA) hydrolase
N2L00_14735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N2L00_14745	COG0179	Fumarylacetoacetate (FAA) hydrolase
N2L00_14755	COG1172	Belongs to the binding-protein-dependent transport system permease family
N2L00_14760	COG1129	ABC transporter
N2L00_14785	COG1846	Transcriptional regulator
N2L00_14810	COG3971	2-oxopent-4-enoate hydratase activity
N2L00_14820	COG1012	belongs to the aldehyde dehydrogenase family
N2L00_14865	COG1902	pentaerythritol trinitrate reductase activity
N2L00_14885	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N2L00_14900	COG0395	ABC-type sugar transport system, permease component
N2L00_14905	COG1175	transmembrane transport
N2L00_14915	COG0673	inositol 2-dehydrogenase activity
N2L00_14920	COG1349	DNA-binding transcription factor activity
N2L00_14925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N2L00_14950	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_14975	COG2314	TM2 domain
N2L00_15015	COG1126	abc transporter atp-binding protein
N2L00_15020	COG2076	Multidrug Resistance protein
N2L00_15040	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_15050	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_15065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N2L00_15080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N2L00_15115	COG0656	L-ascorbic acid biosynthetic process
N2L00_15155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N2L00_15165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N2L00_15170	COG1937	Protein conserved in bacteria
N2L00_15180	COG0730	response to heat
N2L00_15190	COG0477	Major facilitator Superfamily
N2L00_15215	COG1132	(ABC) transporter
N2L00_15235	COG2814	Major facilitator Superfamily
N2L00_15240	COG2409	Drug exporters of the RND superfamily
N2L00_15250	COG0667	Aldo Keto reductase
N2L00_15260	COG0277	FAD linked oxidase domain protein
N2L00_15265	COG1620	l-lactate permease
N2L00_15270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N2L00_15275	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_15285	COG1115	amino acid carrier protein
N2L00_15300	COG0509	glycine decarboxylation via glycine cleavage system
N2L00_15305	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N2L00_15310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N2L00_15310	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N2L00_15315	COG1113	amino acid transport
N2L00_15350	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N2L00_15370	COG0686	Belongs to the AlaDH PNT family
N2L00_15385	COG1309	transcriptional regulator
N2L00_15410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N2L00_15415	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2L00_15420	COG0022	dehydrogenase e1 component
N2L00_15430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N2L00_15435	COG1950	PFAM Membrane protein of
N2L00_15450	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N2L00_15455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N2L00_15465	COG0590	tRNA wobble adenosine to inosine editing
N2L00_15470	COG0789	Transcriptional regulator
N2L00_15480	COG0395	ABC-type sugar transport system, permease component
N2L00_15485	COG1175	transmembrane transport
N2L00_15505	COG2080	2 iron, 2 sulfur cluster binding
N2L00_15510	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
N2L00_15515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N2L00_15550	COG2205	protein histidine kinase activity
N2L00_15555	COG0745	RESPONSE REGULATOR receiver
N2L00_15565	COG1329	Transcriptional regulator
N2L00_15590	COG1063	alcohol dehydrogenase
N2L00_15595	COG5002	protein histidine kinase activity
N2L00_15610	COG0246	Mannitol dehydrogenase
N2L00_15635	COG3145	DNA-N1-methyladenine dioxygenase activity
N2L00_15640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N2L00_15645	COG1595	DNA-templated transcription, initiation
N2L00_15650	COG0318	PFAM AMP-dependent synthetase and ligase
N2L00_15680	COG1191	sigma factor activity
N2L00_15685	COG1619	proteins homologs of microcin C7 resistance protein MccF
N2L00_15695	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N2L00_15710	COG0438	transferase activity, transferring glycosyl groups
N2L00_15715	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N2L00_15720	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N2L00_15720	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N2L00_15725	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_15730	COG0697	spore germination
N2L00_15735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N2L00_15750	COG3655	Transcriptional regulator
N2L00_15775	COG1940	carbohydrate kinase activity
N2L00_15790	COG0318	PFAM AMP-dependent synthetase and ligase
N2L00_15795	COG0477	Major facilitator Superfamily
N2L00_15805	COG1028	Short-chain dehydrogenase reductase Sdr
N2L00_15815	COG1960	acyl-CoA dehydrogenase activity
N2L00_15830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2L00_15860	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N2L00_15860	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N2L00_15865	COG1216	Glycosyl transferase, family 2
N2L00_15885	COG2814	Major facilitator Superfamily
N2L00_15900	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N2L00_15910	COG0531	amino acid
N2L00_15920	COG0305	Participates in initiation and elongation during chromosome replication
N2L00_15925	COG0359	binds to the 23S rRNA
N2L00_15930	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N2L00_15940	COG0360	Binds together with S18 to 16S ribosomal RNA
N2L00_15945	COG1362	aminopeptidase activity
N2L00_15955	COG1131	(ABC) transporter
N2L00_15975	COG0738	Major facilitator superfamily
N2L00_16015	COG1260	myo-inositol-1-phosphate synthase
N2L00_16020	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N2L00_16025	COG0438	transferase activity, transferring glycosyl groups
N2L00_16035	COG0406	alpha-ribazole phosphatase activity
N2L00_16040	COG0617	tRNA 3'-terminal CCA addition
N2L00_16060	COG0492	ferredoxin-NADP+ reductase activity
N2L00_16065	COG3118	belongs to the thioredoxin family
N2L00_16070	COG0860	N-Acetylmuramoyl-L-alanine amidase
N2L00_16070	COG3409	Peptidoglycan-binding domain 1 protein
N2L00_16100	COG1192	Involved in chromosome partitioning
N2L00_16105	COG0357	Ribosomal RNA small subunit methyltransferase G
N2L00_16115	COG0706	membrane insertase activity
N2L00_16120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N2L00_16125	COG0594	ribonuclease P activity
N2L00_16130	COG0230	Belongs to the bacterial ribosomal protein bL34 family