locus-tag	class	description
N2K98_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N2K98_00010	COG0592	DNA-directed DNA polymerase activity
N2K98_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
N2K98_00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
N2K98_00025	COG0187	DNA topoisomerase II activity
N2K98_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N2K98_00035	COG3266	domain, Protein
N2K98_00070	COG0705	Rhomboid family
N2K98_00080	COG3764	Sortase (surface protein transpeptidase)
N2K98_00090	COG0515	serine threonine protein kinase
N2K98_00090	COG2815	serine threonine protein kinase
N2K98_00095	COG0515	serine threonine protein kinase
N2K98_00100	COG0768	penicillin binding
N2K98_00115	COG1716	ATPase activity
N2K98_00120	COG1716	ATPase activity
N2K98_00140	COG0346	lactoylglutathione lyase activity
N2K98_00145	COG0025	NhaP-type Na H and K H
N2K98_00155	COG3265	gluconokinase activity
N2K98_00160	COG2186	Transcriptional regulator
N2K98_00165	COG0783	Belongs to the Dps family
N2K98_00175	COG0723	plastoquinol--plastocyanin reductase activity
N2K98_00180	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_00205	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
N2K98_00235	COG1376	ErfK ybiS ycfS ynhG family protein
N2K98_00240	COG0702	epimerase
N2K98_00265	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_00270	COG1609	Transcriptional regulator
N2K98_00290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N2K98_00300	COG0561	phosphatase activity
N2K98_00305	COG0671	phosphoesterase, PA-phosphatase related
N2K98_00310	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
N2K98_00315	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
N2K98_00325	COG1929	Belongs to the glycerate kinase type-1 family
N2K98_00330	COG2233	PERMEase
N2K98_00340	COG1012	belongs to the aldehyde dehydrogenase family
N2K98_00345	COG0033	Phosphoglucomutase
N2K98_00360	COG3104	oligopeptide transport
N2K98_00365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N2K98_00375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N2K98_00395	COG1597	lipid kinase activity
N2K98_00400	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N2K98_00405	COG0561	phosphatase activity
N2K98_00420	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N2K98_00425	COG2027	D-alanyl-D-alanine carboxypeptidase
N2K98_00435	COG0037	tRNA processing
N2K98_00445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N2K98_00450	COG0302	gtp cyclohydrolase
N2K98_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N2K98_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N2K98_00490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
N2K98_00495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N2K98_00515	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N2K98_00520	COG3237	CsbD-like
N2K98_00525	COG2376	Dihydroxyacetone kinase
N2K98_00530	COG1461	Dihydroxyacetone kinase
N2K98_00550	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
N2K98_00575	COG0581	inorganic phosphate transmembrane transporter activity
N2K98_00580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N2K98_00585	COG0306	phosphate transporter
N2K98_00635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2K98_00640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N2K98_00645	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N2K98_00645	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
N2K98_00645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N2K98_00670	COG2733	membrane
N2K98_00675	COG3387	PFAM Glycoside hydrolase 15-related
N2K98_00690	COG2814	Major facilitator Superfamily
N2K98_00705	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
N2K98_00710	COG0857	belongs to the CobB CobQ family
N2K98_00710	COG0280	phosphate acetyltransferase
N2K98_00715	COG0531	amino acid
N2K98_00725	COG4122	O-methyltransferase activity
N2K98_00745	COG2252	PERMEase
N2K98_00790	COG1302	Protein conserved in bacteria
N2K98_00830	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N2K98_00845	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N2K98_00845	COG0357	Ribosomal RNA small subunit methyltransferase G
N2K98_00850	COG0191	fructose-bisphosphate aldolase activity
N2K98_00885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N2K98_00890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N2K98_00915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
N2K98_00930	COG1832	CoA-binding protein
N2K98_00945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N2K98_00950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2K98_00960	COG1116	anion transmembrane transporter activity
N2K98_00970	COG1832	CoA-binding protein
N2K98_00980	COG2315	Protein conserved in bacteria
N2K98_01000	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N2K98_01005	COG0047	phosphoribosylformylglycinamidine synthase activity
N2K98_01055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N2K98_01075	COG0363	glucosamine-6-phosphate deaminase activity
N2K98_01100	COG3548	integral membrane protein
N2K98_01125	COG2197	response regulator
N2K98_01135	COG0318	PFAM AMP-dependent synthetase and ligase
N2K98_01140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N2K98_01155	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N2K98_01155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N2K98_01215	COG0028	Belongs to the TPP enzyme family
N2K98_01230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N2K98_01240	COG0589	response to stress
N2K98_01275	COG1695	Transcriptional regulator
N2K98_01335	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N2K98_01345	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_01350	COG2072	flavoprotein involved in K transport
N2K98_01360	COG0384	phenazine biosynthesis protein PhzF
N2K98_01365	COG1609	Transcriptional regulator
N2K98_01370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N2K98_01375	COG0765	amino acid transport
N2K98_01380	COG1126	abc transporter atp-binding protein
N2K98_01385	COG0673	inositol 2-dehydrogenase activity
N2K98_01405	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_01430	COG3321	synthase
N2K98_01430	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_01430	COG0604	alcohol dehydrogenase
N2K98_01445	COG2264	protein methyltransferase activity
N2K98_01455	COG0542	response to heat
N2K98_01475	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_01485	COG1309	transcriptional regulator
N2K98_01505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N2K98_01515	COG0386	Belongs to the glutathione peroxidase family
N2K98_01550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N2K98_01580	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N2K98_01585	COG2224	Isocitrate lyase
N2K98_01595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N2K98_01600	COG1404	Belongs to the peptidase S8 family
N2K98_01605	COG1216	Glycosyl transferase, family 2
N2K98_01615	COG0351	phosphomethylpyrimidine kinase
N2K98_01620	COG1309	transcriptional regulator
N2K98_01640	COG0343	queuine tRNA-ribosyltransferase activity
N2K98_01680	COG1960	acyl-CoA dehydrogenase activity
N2K98_01700	COG0564	pseudouridine synthase activity
N2K98_01705	COG0659	secondary active sulfate transmembrane transporter activity
N2K98_01710	COG0515	serine threonine protein kinase
N2K98_01715	COG1846	Transcriptional regulator
N2K98_01725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2K98_01730	COG1120	ATPase activity
N2K98_01745	COG0583	DNA-binding transcription factor activity
N2K98_01750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N2K98_01755	COG1201	RNA secondary structure unwinding
N2K98_01775	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N2K98_01810	COG3546	catalase activity
N2K98_01835	COG4589	Belongs to the CDS family
N2K98_01850	COG0590	tRNA wobble adenosine to inosine editing
N2K98_01855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N2K98_01865	COG2062	phosphohistidine phosphatase, SixA
N2K98_01870	COG1511	domain protein
N2K98_01895	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
N2K98_01910	COG0514	ATP-dependent DNA helicase (RecQ)
N2K98_01925	COG1024	Enoyl-CoA hydratase
N2K98_01935	COG0667	Aldo Keto reductase
N2K98_01950	COG1505	serine-type exopeptidase activity
N2K98_02010	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N2K98_02025	COG2072	flavoprotein involved in K transport
N2K98_02040	COG0604	alcohol dehydrogenase
N2K98_02045	COG1966	Carbon starvation protein
N2K98_02065	COG0656	L-ascorbic acid biosynthetic process
N2K98_02095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N2K98_02115	COG1815	bacterial-type flagellum-dependent cell motility
N2K98_02120	COG1558	bacterial-type flagellum-dependent cell motility
N2K98_02125	COG1677	Flagellar hook-basal body complex protein FliE
N2K98_02130	COG1766	The M ring may be actively involved in energy transduction
N2K98_02135	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N2K98_02145	COG1157	protein secretion by the type III secretion system
N2K98_02165	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
N2K98_02180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N2K98_02185	COG1360	Flagellar Motor Protein
N2K98_02205	COG1338	Plays a role in the flagellum-specific transport system
N2K98_02210	COG1987	bacterial-type flagellum assembly
N2K98_02220	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N2K98_02225	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N2K98_02235	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N2K98_02255	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N2K98_02260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N2K98_02265	COG0626	cystathionine gamma-synthase activity
N2K98_02280	COG0588	phosphoglycerate mutase activity
N2K98_02290	COG5002	protein histidine kinase activity
N2K98_02295	COG0745	RESPONSE REGULATOR receiver
N2K98_02310	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N2K98_02315	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N2K98_02320	COG0215	cysteine-tRNA ligase activity
N2K98_02325	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N2K98_02340	COG0366	Alpha amylase catalytic
N2K98_02350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N2K98_02395	COG0277	FAD linked oxidase domain protein
N2K98_02400	COG0366	Alpha amylase catalytic
N2K98_02415	COG3842	ATPase activity
N2K98_02460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N2K98_02470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N2K98_02475	COG0477	Major facilitator Superfamily
N2K98_02480	COG0477	Major facilitator Superfamily
N2K98_02485	COG1957	nucleoside hydrolase
N2K98_02495	COG0604	alcohol dehydrogenase
N2K98_02520	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2K98_02525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2K98_02555	COG2828	Protein conserved in bacteria
N2K98_02560	COG2159	amidohydrolase
N2K98_02600	COG2807	transmembrane transport
N2K98_02605	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_02610	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_02615	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N2K98_02615	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N2K98_02620	COG2365	Tyrosine phosphatase family
N2K98_02660	COG0667	Aldo Keto reductase
N2K98_02690	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N2K98_02710	COG0459	protein refolding
N2K98_02720	COG2205	protein histidine kinase activity
N2K98_02725	COG0745	RESPONSE REGULATOR receiver
N2K98_02745	COG1278	Cold shock
N2K98_02770	COG0739	heme binding
N2K98_02790	COG0746	molybdenum cofactor guanylyltransferase activity
N2K98_02800	COG0303	'Molybdopterin
N2K98_02805	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N2K98_02810	COG5002	protein histidine kinase activity
N2K98_02815	COG1132	(ABC) transporter
N2K98_02840	COG0483	inositol monophosphate 1-phosphatase activity
N2K98_02850	COG0045	succinate-CoA ligase (ADP-forming) activity
N2K98_02860	COG2814	Major facilitator Superfamily
N2K98_02885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N2K98_02930	COG0318	PFAM AMP-dependent synthetase and ligase
N2K98_02945	COG1396	sequence-specific DNA binding
N2K98_02960	COG0028	Belongs to the TPP enzyme family
N2K98_02985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
N2K98_02995	COG0514	ATP-dependent DNA helicase (RecQ)
N2K98_03070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N2K98_03085	COG2188	Transcriptional regulator
N2K98_03090	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N2K98_03095	COG3395	kinase activity
N2K98_03115	COG3387	PFAM Glycoside hydrolase 15-related
N2K98_03120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N2K98_03150	COG0640	Transcriptional regulator
N2K98_03155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N2K98_03160	COG1914	H( )-stimulated, divalent metal cation uptake system
N2K98_03165	COG1914	H( )-stimulated, divalent metal cation uptake system
N2K98_03170	COG4336	lyase activity
N2K98_03180	COG4770	biotin carboxylase activity
N2K98_03185	COG1984	allophanate hydrolase subunit 2
N2K98_03190	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N2K98_03195	COG0277	FAD linked oxidase domain protein
N2K98_03230	COG0477	Major facilitator Superfamily
N2K98_03235	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N2K98_03240	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_03245	COG1250	3-hydroxyacyl-CoA dehydrogenase
N2K98_03260	COG0673	inositol 2-dehydrogenase activity
N2K98_03265	COG1879	ABC-type sugar transport system periplasmic component
N2K98_03270	COG1129	ABC transporter
N2K98_03275	COG1172	Belongs to the binding-protein-dependent transport system permease family
N2K98_03280	COG1940	carbohydrate kinase activity
N2K98_03300	COG0800	Aldolase
N2K98_03305	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_03310	COG1063	alcohol dehydrogenase
N2K98_03320	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
N2K98_03330	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N2K98_03355	COG1397	ADP-ribosylglycohydrolase
N2K98_03380	COG1074	ATP-dependent DNA helicase activity
N2K98_03460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N2K98_03470	COG1201	RNA secondary structure unwinding
N2K98_03475	COG0210	DNA helicase
N2K98_03485	COG2235	arginine
N2K98_03515	COG3949	Membrane
N2K98_03575	COG1960	acyl-CoA dehydrogenase activity
N2K98_03580	COG0183	Belongs to the thiolase family
N2K98_03610	COG1358	cellular component organization or biogenesis
N2K98_03685	COG1024	Enoyl-CoA hydratase
N2K98_03690	COG1250	3-hydroxyacyl-CoA dehydrogenase
N2K98_03700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N2K98_03710	COG2115	Belongs to the xylose isomerase family
N2K98_03715	COG1070	Carbohydrate kinase
N2K98_03720	COG2017	converts alpha-aldose to the beta-anomer
N2K98_03735	COG3458	cephalosporin-C deacetylase activity
N2K98_03740	COG1472	Belongs to the glycosyl hydrolase 3 family
N2K98_03750	COG1175	transmembrane transport
N2K98_03755	COG1653	transport
N2K98_03760	COG1609	Transcriptional regulator
N2K98_03780	COG2390	Transcriptional regulator
N2K98_03785	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N2K98_03790	COG0738	Major facilitator superfamily
N2K98_03800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N2K98_03810	COG2814	Major facilitator Superfamily
N2K98_03815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N2K98_03820	COG0693	protein deglycase activity
N2K98_03825	COG0667	Aldo Keto reductase
N2K98_03835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N2K98_03855	COG0247	lactate metabolic process
N2K98_03860	COG1139	Iron-sulfur cluster binding protein
N2K98_03865	COG1556	Lactate utilization protein
N2K98_03875	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N2K98_03885	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N2K98_03890	COG1620	l-lactate permease
N2K98_03895	COG3619	membrane
N2K98_03905	COG0039	L-malate dehydrogenase activity
N2K98_03915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N2K98_03925	COG2323	membrane
N2K98_03930	COG2304	oxidoreductase activity
N2K98_03935	COG1278	Cold shock
N2K98_03940	COG2066	Belongs to the glutaminase family
N2K98_03940	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
N2K98_03945	COG1278	Cold shock
N2K98_03955	COG0515	serine threonine protein kinase
N2K98_03955	COG2815	serine threonine protein kinase
N2K98_03960	COG3012	SEC-C Motif Domain Protein
N2K98_03965	COG1063	alcohol dehydrogenase
N2K98_03980	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
N2K98_03990	COG0829	nickel cation binding
N2K98_03995	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N2K98_04005	COG0804	urea catabolic process
N2K98_04015	COG0831	urea catabolic process
N2K98_04040	COG0753	catalase activity
N2K98_04105	COG0477	Major facilitator Superfamily
N2K98_04115	COG0138	bifunctional purine biosynthesis protein purh
N2K98_04125	COG0385	Bile acid
N2K98_04170	COG1172	Belongs to the binding-protein-dependent transport system permease family
N2K98_04175	COG1129	ABC transporter
N2K98_04205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N2K98_04210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
N2K98_04240	COG0708	Exodeoxyribonuclease III
N2K98_04245	COG0180	Tryptophanyl-tRNA synthetase
N2K98_04260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N2K98_04275	COG2009	succinate dehydrogenase
N2K98_04285	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N2K98_04285	COG1473	amidohydrolase
N2K98_04290	COG1744	ABC transporter substrate-binding protein PnrA-like
N2K98_04295	COG3845	ABC transporter
N2K98_04300	COG4603	Belongs to the binding-protein-dependent transport system permease family
N2K98_04305	COG1079	Belongs to the binding-protein-dependent transport system permease family
N2K98_04325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N2K98_04330	COG3956	TIGRFAM MazG family protein
N2K98_04335	COG0148	phosphopyruvate hydratase activity
N2K98_04395	COG0559	Belongs to the binding-protein-dependent transport system permease family
N2K98_04410	COG2017	converts alpha-aldose to the beta-anomer
N2K98_04420	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N2K98_04425	COG0705	Rhomboid family
N2K98_04430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
N2K98_04440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N2K98_04450	COG1331	Highly conserved protein containing a thioredoxin domain
N2K98_04460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N2K98_04465	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
N2K98_04480	COG0477	Major facilitator Superfamily
N2K98_04490	COG0114	fumarate hydratase activity
N2K98_04505	COG1494	fructose-1,6-bisphosphatase
N2K98_04520	COG1316	TRANSCRIPTIONal
N2K98_04575	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N2K98_04625	COG0714	Associated with various cellular activities
N2K98_04630	COG0084	hydrolase, TatD family'
N2K98_04650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N2K98_04655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
N2K98_04660	COG0488	(ABC) transporter
N2K98_04680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N2K98_04685	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N2K98_04690	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N2K98_04695	COG0193	aminoacyl-tRNA hydrolase activity
N2K98_04765	COG1216	Glycosyl transferase, family 2
N2K98_04805	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
N2K98_04825	COG0489	protein tyrosine kinase activity
N2K98_04850	COG0438	transferase activity, transferring glycosyl groups
N2K98_04875	COG5002	protein histidine kinase activity
N2K98_04885	COG5002	protein histidine kinase activity
N2K98_04930	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N2K98_04965	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N2K98_04990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N2K98_05005	COG0477	Major facilitator Superfamily
N2K98_05010	COG4770	biotin carboxylase activity
N2K98_05020	COG0424	maF-like protein
N2K98_05025	COG1823	symporter activity
N2K98_05040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N2K98_05070	COG0714	Associated with various cellular activities
N2K98_05085	COG0631	protein serine/threonine phosphatase activity
N2K98_05115	COG1674	ftsk spoiiie
N2K98_05185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N2K98_05190	COG0483	inositol monophosphate 1-phosphatase activity
N2K98_05215	COG0456	acetyltransferase
N2K98_05220	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N2K98_05225	COG0154	amidase activity
N2K98_05230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N2K98_05240	COG1653	transport
N2K98_05245	COG1175	transmembrane transport
N2K98_05250	COG0395	ABC-type sugar transport system, permease component
N2K98_05255	COG4948	Mandelate Racemase Muconate Lactonizing
N2K98_05260	COG0800	Aldolase
N2K98_05285	COG1254	Belongs to the acylphosphatase family
N2K98_05290	COG2986	histidine ammonia-lyase
N2K98_05295	COG1414	Transcriptional regulator
N2K98_05300	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
N2K98_05315	COG1228	amidohydrolase
N2K98_05325	COG3250	beta-galactosidase activity
N2K98_05340	COG2873	o-acetylhomoserine
N2K98_05345	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N2K98_05365	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N2K98_05380	COG2822	iron ion transport
N2K98_05385	COG2837	iron assimilation
N2K98_05400	COG0423	glycine-tRNA ligase activity
N2K98_05415	COG2031	fatty acid transporter
N2K98_05435	COG0358	DNA primase activity
N2K98_05455	COG0477	Major facilitator Superfamily
N2K98_05475	COG0297	glycogen (starch) synthase activity
N2K98_05740	COG0419	ATPase involved in DNA repair
N2K98_05785	COG0582	viral genome integration into host DNA
N2K98_05790	COG1960	acyl-CoA dehydrogenase activity
N2K98_05800	COG0052	Belongs to the universal ribosomal protein uS2 family
N2K98_05805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N2K98_05810	COG0528	UMP kinase activity
N2K98_05815	COG0233	cytoplasmic translational termination
N2K98_05820	COG0575	Belongs to the CDS family
N2K98_05830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N2K98_05840	COG3279	Response regulator of the LytR AlgR family
N2K98_05845	COG3275	phosphorelay sensor kinase activity
N2K98_05855	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N2K98_05870	COG0022	dehydrogenase e1 component
N2K98_05875	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2K98_05885	COG1309	transcriptional regulator
N2K98_05890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N2K98_05900	COG1960	acyl-CoA dehydrogenase activity
N2K98_05930	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N2K98_05935	COG0750	zinc metalloprotease
N2K98_05965	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N2K98_05985	COG0442	prolyl-tRNA aminoacylation
N2K98_06005	COG0779	Required for maturation of 30S ribosomal subunits
N2K98_06020	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N2K98_06025	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
N2K98_06030	COG1472	Belongs to the glycosyl hydrolase 3 family
N2K98_06035	COG0436	Aminotransferase
N2K98_06040	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
N2K98_06065	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N2K98_06070	COG1185	polyribonucleotide nucleotidyltransferase activity
N2K98_06075	COG0612	Peptidase, M16
N2K98_06090	COG0725	ABC transporter, periplasmic molybdate-binding protein
N2K98_06115	COG0521	Mo-molybdopterin cofactor biosynthetic process
N2K98_06125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N2K98_06140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N2K98_06145	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N2K98_06150	COG1674	ftsk spoiiie
N2K98_06160	COG1058	Belongs to the CinA family
N2K98_06160	COG1546	Belongs to the CinA family
N2K98_06165	COG1396	sequence-specific DNA binding
N2K98_06180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N2K98_06185	COG2137	regulation of response to DNA damage stimulus
N2K98_06200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N2K98_06205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
N2K98_06210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N2K98_06215	COG2813	Specifically methylates the guanine in position
N2K98_06220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N2K98_06230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
N2K98_06240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N2K98_06245	COG0131	Imidazoleglycerol-phosphate dehydratase
N2K98_06250	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N2K98_06260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N2K98_06280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N2K98_06285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N2K98_06290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N2K98_06295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N2K98_06305	COG2814	Major facilitator Superfamily
N2K98_06310	COG2890	protein-(glutamine-N5) methyltransferase activity
N2K98_06330	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N2K98_06335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N2K98_06335	COG0072	phenylalanine-tRNA ligase activity
N2K98_06355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N2K98_06360	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
N2K98_06365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N2K98_06370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N2K98_06375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N2K98_06380	COG1438	arginine binding
N2K98_06385	COG0137	argininosuccinate synthase activity
N2K98_06390	COG0165	Argininosuccinate lyase
N2K98_06395	COG0259	pyridoxamine-phosphate oxidase activity
N2K98_06410	COG2094	Belongs to the DNA glycosylase MPG family
N2K98_06420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N2K98_06430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N2K98_06480	COG0647	UMP catabolic process
N2K98_06495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N2K98_06500	COG0497	DNA recombination
N2K98_06505	COG0504	CTP synthase activity
N2K98_06510	COG0494	nUDIX hydrolase
N2K98_06520	COG1051	belongs to the nudix hydrolase family
N2K98_06530	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
N2K98_06535	COG2079	MmgE PrpD family protein
N2K98_06545	COG4566	intracellular signal transduction
N2K98_06560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N2K98_06570	COG2376	Dihydroxyacetone kinase
N2K98_06580	COG4565	transcriptional regulatory protein
N2K98_06585	COG3290	protein histidine kinase activity
N2K98_06590	COG1301	dicarboxylic acid transport
N2K98_06605	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
N2K98_06610	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
N2K98_06620	COG0287	Prephenate dehydrogenase
N2K98_06625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N2K98_06630	COG1160	GTP binding
N2K98_06650	COG2197	response regulator
N2K98_06660	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_06665	COG2133	pyrroloquinoline quinone binding
N2K98_06675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N2K98_06725	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
N2K98_06735	COG1022	Amp-dependent synthetase and ligase
N2K98_06740	COG1940	carbohydrate kinase activity
N2K98_06760	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
N2K98_06765	COG0515	serine threonine protein kinase
N2K98_06765	COG2815	serine threonine protein kinase
N2K98_06770	COG0741	lytic transglycosylase activity
N2K98_06780	COG0142	geranyltranstransferase activity
N2K98_06790	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N2K98_06800	COG2001	Belongs to the MraZ family
N2K98_06805	COG0275	rRNA processing
N2K98_06815	COG0768	penicillin binding
N2K98_06830	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N2K98_06835	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N2K98_06845	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
N2K98_06850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N2K98_06860	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N2K98_06865	COG1496	oxidoreductase activity
N2K98_06875	COG1799	cell septum assembly
N2K98_06885	COG3599	regulation of cell shape
N2K98_06890	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N2K98_06900	COG0587	DNA-directed DNA polymerase activity
N2K98_06905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N2K98_06910	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N2K98_06930	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
N2K98_06935	COG0174	glutamine synthetase
N2K98_06940	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N2K98_06945	COG0765	amino acid transport
N2K98_06950	COG1126	abc transporter atp-binding protein
N2K98_06970	COG0657	acetylesterase activity
N2K98_06990	COG1063	alcohol dehydrogenase
N2K98_07015	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
N2K98_07020	COG0321	lipoyl(octanoyl) transferase activity
N2K98_07030	COG0793	Belongs to the peptidase S41A family
N2K98_07030	COG4946	Tricorn protease homolog
N2K98_07035	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N2K98_07040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N2K98_07050	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
N2K98_07055	COG0829	nickel cation binding
N2K98_07060	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
N2K98_07065	COG0830	nickel cation binding
N2K98_07070	COG0804	urea catabolic process
N2K98_07075	COG0832	Belongs to the urease beta subunit family
N2K98_07085	COG0831	urea catabolic process
N2K98_07090	COG1764	response to oxidative stress
N2K98_07100	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2K98_07105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N2K98_07110	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N2K98_07125	COG1131	(ABC) transporter
N2K98_07140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N2K98_07150	COG0187	DNA topoisomerase II activity
N2K98_07165	COG1271	oxidase subunit
N2K98_07170	COG1294	oxidase, subunit
N2K98_07175	COG4988	ABC transporter
N2K98_07180	COG0454	-acetyltransferase
N2K98_07180	COG0456	acetyltransferase
N2K98_07190	COG1937	Protein conserved in bacteria
N2K98_07205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N2K98_07220	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
N2K98_07225	COG1435	thymidine kinase activity
N2K98_07245	COG0756	dUTP diphosphatase activity
N2K98_07270	COG0569	domain protein
N2K98_07275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N2K98_07280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
N2K98_07285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N2K98_07300	COG0667	Aldo Keto reductase
N2K98_07320	COG4221	oxidoreductase activity
N2K98_07325	COG1024	Enoyl-CoA hydratase
N2K98_07325	COG1250	3-hydroxyacyl-CoA dehydrogenase
N2K98_07330	COG0183	Belongs to the thiolase family
N2K98_07345	COG0657	acetylesterase activity
N2K98_07365	COG1216	Glycosyl transferase, family 2
N2K98_07385	COG0737	Belongs to the 5'-nucleotidase family
N2K98_07400	COG2318	DinB family
N2K98_07450	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
N2K98_07465	COG0183	Belongs to the thiolase family
N2K98_07485	COG1653	transport
N2K98_07500	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
N2K98_07505	COG4989	oxidoreductase activity
N2K98_07520	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
N2K98_07540	COG1269	ATP hydrolysis coupled proton transport
N2K98_07565	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N2K98_07580	COG2226	methyltransferase
N2K98_07585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N2K98_07710	COG0242	peptide deformylase activity
N2K98_07715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N2K98_07725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N2K98_07740	COG4335	DNA alkylation repair
N2K98_07750	COG0477	Major facilitator Superfamily
N2K98_07760	COG0640	Transcriptional regulator
N2K98_07765	COG0798	PFAM Bile acid sodium symporter
N2K98_07770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N2K98_07790	COG1309	transcriptional regulator
N2K98_07805	COG0667	Aldo Keto reductase
N2K98_07810	COG1309	transcriptional regulator
N2K98_07820	COG1476	TRANSCRIPTIONal
N2K98_07890	COG1131	(ABC) transporter
N2K98_07900	COG0477	Major facilitator Superfamily
N2K98_07910	COG1064	alcohol dehydrogenase
N2K98_07930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N2K98_07955	COG3655	Transcriptional regulator
N2K98_07980	COG4941	Belongs to the sigma-70 factor family
N2K98_07985	COG3795	YCII-related domain
N2K98_08005	COG4106	trans-aconitate 2-methyltransferase activity
N2K98_08010	COG0140	phosphoribosyl-ATP diphosphatase activity
N2K98_08015	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N2K98_08020	COG0107	imidazoleglycerol-phosphate synthase activity
N2K98_08050	COG1064	alcohol dehydrogenase
N2K98_08055	COG2354	Protein conserved in bacteria
N2K98_08070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N2K98_08090	COG0134	indole-3-glycerol-phosphate synthase activity
N2K98_08095	COG0133	tryptophan synthase activity
N2K98_08100	COG0159	tryptophan synthase activity
N2K98_08105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
N2K98_08110	COG0067	glutamate synthase
N2K98_08110	COG0069	glutamate synthase activity
N2K98_08110	COG0070	glutamate synthase
N2K98_08145	COG0469	pyruvate kinase activity
N2K98_08160	COG1309	transcriptional regulator
N2K98_08170	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_08180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N2K98_08225	COG1876	peptidase activity
N2K98_08245	COG1595	DNA-templated transcription, initiation
N2K98_08270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N2K98_08280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N2K98_08310	COG2124	cytochrome p450
N2K98_08320	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
N2K98_08325	COG1309	transcriptional regulator
N2K98_08330	COG0778	Nitroreductase
N2K98_08335	COG1329	Transcriptional regulator
N2K98_08340	COG1643	Atp-dependent helicase
N2K98_08365	COG2814	Major facilitator Superfamily
N2K98_08390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N2K98_08395	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_08400	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_08405	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_08420	COG0535	radical SAM domain protein
N2K98_08440	COG1960	acyl-CoA dehydrogenase activity
N2K98_08475	COG0488	(ABC) transporter
N2K98_08495	COG1785	Belongs to the alkaline phosphatase family
N2K98_08500	COG0009	L-threonylcarbamoyladenylate synthase
N2K98_08520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N2K98_08525	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N2K98_08540	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_08555	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
N2K98_08560	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
N2K98_08565	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
N2K98_08580	COG3103	Sh3 type 3 domain protein
N2K98_08580	COG0791	NLP P60 protein
N2K98_08580	COG1388	LysM domain
N2K98_08585	COG2814	Major facilitator Superfamily
N2K98_08595	COG0425	Belongs to the sulfur carrier protein TusA family
N2K98_08600	COG2391	methyltransferase activity
N2K98_08605	COG1215	transferase activity, transferring glycosyl groups
N2K98_08620	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_08630	COG2272	Belongs to the type-B carboxylesterase lipase family
N2K98_08640	COG0488	(ABC) transporter
N2K98_08645	COG2272	Belongs to the type-B carboxylesterase lipase family
N2K98_08665	COG1607	acyl-coa hydrolase
N2K98_08680	COG1216	Glycosyl transferase, family 2
N2K98_08690	COG1472	Belongs to the glycosyl hydrolase 3 family
N2K98_08695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N2K98_08700	COG0477	Major facilitator Superfamily
N2K98_08705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N2K98_08710	COG1082	Xylose isomerase domain protein TIM barrel
N2K98_08710	COG3185	4-Hydroxyphenylpyruvate dioxygenase
N2K98_08715	COG1414	Transcriptional regulator
N2K98_08725	COG0531	amino acid
N2K98_08730	COG0076	glutamate decarboxylase activity
N2K98_08740	COG2814	Major facilitator Superfamily
N2K98_08755	COG1902	pentaerythritol trinitrate reductase activity
N2K98_08760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N2K98_08765	COG2050	protein possibly involved in aromatic compounds catabolism
N2K98_08775	COG4552	Acetyltransferase involved in intracellular survival and related
N2K98_08780	COG0539	negative regulation of cytoplasmic translation
N2K98_08800	COG2723	6-phospho-beta-galactosidase activity
N2K98_08810	COG1175	transmembrane transport
N2K98_08820	COG2813	Specifically methylates the guanine in position
N2K98_08825	COG1739	Uncharacterized protein family UPF0029
N2K98_08830	COG0237	dephospho-CoA kinase activity
N2K98_08830	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
N2K98_08835	COG0556	nucleotide-excision repair
N2K98_08865	COG4106	trans-aconitate 2-methyltransferase activity
N2K98_08910	COG0322	excinuclease ABC activity
N2K98_08915	COG1660	Displays ATPase and GTPase activities
N2K98_08920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N2K98_08925	COG1481	regulation of sporulation
N2K98_08940	COG0126	phosphoglycerate kinase activity
N2K98_08945	COG0149	triose-phosphate isomerase activity
N2K98_08950	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N2K98_08955	COG0363	glucosamine-6-phosphate deaminase activity
N2K98_08975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N2K98_08985	COG0109	protoheme IX farnesyltransferase activity
N2K98_08990	COG1612	heme a metabolic process
N2K98_09000	COG1131	(ABC) transporter
N2K98_09020	COG0396	ATPase activity
N2K98_09025	COG2151	metal-sulfur cluster biosynthetic enzyme
N2K98_09050	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N2K98_09055	COG1122	ATPase activity
N2K98_09060	COG1268	BioY protein
N2K98_09065	COG0488	(ABC) transporter
N2K98_09090	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_09095	COG0560	Phosphoserine phosphatase
N2K98_09095	COG3830	Belongs to the UPF0237 family
N2K98_09100	COG1119	ATPase activity
N2K98_09115	COG0254	rRNA binding
N2K98_09140	COG2855	membrane
N2K98_09145	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N2K98_09160	COG0297	glycogen (starch) synthase activity
N2K98_09175	COG0183	Belongs to the thiolase family
N2K98_09180	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_09195	COG0589	response to stress
N2K98_09200	COG0531	amino acid
N2K98_09205	COG1253	flavin adenine dinucleotide binding
N2K98_09215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N2K98_09235	COG1968	undecaprenyl-diphosphatase activity
N2K98_09240	COG0215	cysteine-tRNA ligase activity
N2K98_09250	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N2K98_09255	COG1994	Peptidase M50
N2K98_09255	COG0517	IMP dehydrogenase activity
N2K98_09265	COG1222	aaa ATPase
N2K98_09270	COG4122	O-methyltransferase activity
N2K98_09280	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N2K98_09285	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N2K98_09290	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N2K98_09295	COG0545	Peptidyl-prolyl cis-trans isomerase
N2K98_09315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N2K98_09320	COG0805	protein transport
N2K98_09325	COG4581	dead DEAH box helicase
N2K98_09330	COG1574	metal-dependent hydrolase with the TIM-barrel fold
N2K98_09335	COG1216	Glycosyl transferase, family 2
N2K98_09360	COG0823	Involved in the tonB-independent uptake of proteins
N2K98_09360	COG1506	peptidase
N2K98_09360	COG4946	Tricorn protease homolog
N2K98_09365	COG0242	peptide deformylase activity
N2K98_09395	COG0740	serine-type endopeptidase activity
N2K98_09400	COG0740	serine-type endopeptidase activity
N2K98_09415	COG0366	Alpha amylase catalytic
N2K98_09460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N2K98_09465	COG1845	cytochrome c oxidase, subunit III
N2K98_09470	COG2010	Cytochrome c
N2K98_09475	COG0723	plastoquinol--plastocyanin reductase activity
N2K98_09480	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N2K98_09490	COG2188	Transcriptional regulator
N2K98_09500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N2K98_09505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
N2K98_09525	COG0167	dihydroorotate dehydrogenase activity
N2K98_09535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N2K98_09540	COG1381	Involved in DNA repair and RecF pathway recombination
N2K98_09545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N2K98_09550	COG1316	TRANSCRIPTIONal
N2K98_09555	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N2K98_09565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N2K98_09585	COG0484	heat shock protein binding
N2K98_09590	COG1420	regulation of RNA biosynthetic process
N2K98_09610	COG0481	GTPase activity
N2K98_09620	COG0268	Binds directly to 16S ribosomal RNA
N2K98_09640	COG1349	DNA-binding transcription factor activity
N2K98_09655	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_09655	COG3347	Dehydrogenase
N2K98_09665	COG1129	ABC transporter
N2K98_09670	COG1172	Belongs to the binding-protein-dependent transport system permease family
N2K98_09685	COG2376	Dihydroxyacetone kinase
N2K98_09690	COG0698	ribose 5-phosphate isomerase
N2K98_09695	COG1307	EDD domain protein, DegV family
N2K98_09700	COG0495	leucyl-tRNA aminoacylation
N2K98_09715	COG0385	Bile acid
N2K98_09720	COG2072	flavoprotein involved in K transport
N2K98_09725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N2K98_09730	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N2K98_09735	COG0656	L-ascorbic acid biosynthetic process
N2K98_09740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N2K98_09745	COG0438	transferase activity, transferring glycosyl groups
N2K98_09750	COG2130	NADP-dependent
N2K98_09755	COG1846	Transcriptional regulator
N2K98_09770	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
N2K98_09790	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N2K98_09800	COG1758	RNA polymerase activity
N2K98_09805	COG0194	GDP metabolic process
N2K98_09810	COG0194	GDP metabolic process
N2K98_09815	COG0284	orotidine-5'-phosphate decarboxylase activity
N2K98_09820	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N2K98_09825	COG0505	Belongs to the CarA family
N2K98_09835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N2K98_09840	COG0540	Belongs to the ATCase OTCase family
N2K98_09845	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N2K98_09855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N2K98_09860	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N2K98_09865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N2K98_09875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N2K98_09880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N2K98_09890	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
N2K98_09895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N2K98_09910	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N2K98_09930	COG0384	phenazine biosynthesis protein PhzF
N2K98_09935	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N2K98_09945	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
N2K98_09960	COG2197	response regulator
N2K98_09965	COG0124	histidyl-tRNA synthetase
N2K98_09975	COG1196	nuclear chromosome segregation
N2K98_09985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N2K98_09990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N2K98_09995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N2K98_10005	COG2255	four-way junction helicase activity
N2K98_10010	COG0632	four-way junction helicase activity
N2K98_10015	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N2K98_10020	COG0217	transcriptional regulatory protein
N2K98_10025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N2K98_10060	COG0339	signal peptide processing
N2K98_10065	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N2K98_10075	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N2K98_10080	COG0587	DNA-directed DNA polymerase activity
N2K98_10110	COG2365	Tyrosine phosphatase family
N2K98_10140	COG2135	peptidase activity
N2K98_10230	COG2814	Major facilitator Superfamily
N2K98_10240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N2K98_10275	COG0667	Aldo Keto reductase
N2K98_10280	COG2135	peptidase activity
N2K98_10300	COG0656	L-ascorbic acid biosynthetic process
N2K98_10320	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N2K98_10335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
N2K98_10350	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_10390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N2K98_10405	COG1131	(ABC) transporter
N2K98_10410	COG2318	DinB family
N2K98_10420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N2K98_10425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N2K98_10505	COG0588	phosphoglycerate mutase activity
N2K98_10520	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
N2K98_10530	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N2K98_10535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N2K98_10540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N2K98_10545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N2K98_10550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N2K98_10555	COG1530	ribonuclease E activity
N2K98_10575	COG0105	UTP biosynthetic process
N2K98_10585	COG0285	dihydrofolate synthase activity
N2K98_10590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N2K98_10610	COG0525	valine-tRNA ligase activity
N2K98_10615	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
N2K98_10620	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N2K98_10625	COG0740	serine-type endopeptidase activity
N2K98_10655	COG0698	ribose 5-phosphate isomerase
N2K98_10675	COG0668	transmembrane transport
N2K98_10690	COG0824	Thioesterase
N2K98_10695	COG1946	Acyl-CoA thioesterase
N2K98_10710	COG0629	single-stranded DNA binding
N2K98_10715	COG0657	acetylesterase activity
N2K98_10785	COG0242	peptide deformylase activity
N2K98_10805	COG3022	response to hydroperoxide
N2K98_10815	COG1579	Zn-ribbon protein possibly nucleic acid-binding
N2K98_10820	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N2K98_10825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N2K98_10835	COG1045	serine acetyltransferase
N2K98_10840	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N2K98_10870	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N2K98_10890	COG1175	transmembrane transport
N2K98_10895	COG0395	ABC-type sugar transport system, permease component
N2K98_10915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N2K98_10920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N2K98_10935	COG4974	Belongs to the 'phage' integrase family
N2K98_10955	COG0792	nuclease activity
N2K98_10960	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_10985	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N2K98_10990	COG0681	Belongs to the peptidase S26 family
N2K98_10995	COG0681	Belongs to the peptidase S26 family
N2K98_11000	COG0335	large ribosomal subunit rRNA binding
N2K98_11005	COG0336	Belongs to the RNA methyltransferase TrmD family
N2K98_11010	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N2K98_11015	COG1837	Belongs to the UPF0109 family
N2K98_11020	COG0228	four-way junction DNA binding
N2K98_11025	COG2514	catechol 2,3-dioxygenase activity
N2K98_11060	COG0552	protein localization to endoplasmic reticulum
N2K98_11065	COG0477	Major facilitator Superfamily
N2K98_11080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N2K98_11085	COG0318	PFAM AMP-dependent synthetase and ligase
N2K98_11090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N2K98_11110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
N2K98_11135	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N2K98_11140	COG0571	ribonuclease III activity
N2K98_11145	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N2K98_11155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N2K98_11170	COG0742	ribosomal rna small subunit methyltransferase
N2K98_11180	COG1461	Dihydroxyacetone kinase
N2K98_11185	COG1316	TRANSCRIPTIONal
N2K98_11195	COG1181	Belongs to the D-alanine--D-alanine ligase family
N2K98_11200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
N2K98_11210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N2K98_11215	COG0066	3-isopropylmalate dehydratase activity
N2K98_11220	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N2K98_11225	COG1414	Transcriptional regulator
N2K98_11255	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N2K98_11265	COG0179	Fumarylacetoacetate (FAA) hydrolase
N2K98_11290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N2K98_11295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N2K98_11300	COG0473	3-isopropylmalate dehydrogenase activity
N2K98_11305	COG4585	Histidine kinase
N2K98_11310	COG2197	response regulator
N2K98_11345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N2K98_11350	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N2K98_11355	COG0440	acetolactate synthase activity
N2K98_11365	COG0129	dihydroxy-acid dehydratase activity
N2K98_11375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N2K98_11405	COG1690	Belongs to the RtcB family
N2K98_11425	COG0747	negative chemotaxis
N2K98_11430	COG0601	transmembrane transport
N2K98_11435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N2K98_11450	COG0747	negative chemotaxis
N2K98_11455	COG0579	oxidoreductase
N2K98_11460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N2K98_11480	COG2814	Major facilitator Superfamily
N2K98_11485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N2K98_11490	COG1522	sequence-specific DNA binding
N2K98_11495	COG1113	amino acid transport
N2K98_11505	COG0022	dehydrogenase e1 component
N2K98_11510	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2K98_11520	COG0515	serine threonine protein kinase
N2K98_11535	COG0419	ATPase involved in DNA repair
N2K98_11540	COG0420	3'-5' exonuclease activity
N2K98_11545	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N2K98_11560	COG0586	Pfam SNARE associated Golgi protein
N2K98_11565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N2K98_11570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N2K98_11585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N2K98_11595	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
N2K98_11605	COG1335	isochorismatase
N2K98_11625	COG1131	(ABC) transporter
N2K98_11630	COG1902	pentaerythritol trinitrate reductase activity
N2K98_11655	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
N2K98_11670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N2K98_11680	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N2K98_11685	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N2K98_11690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N2K98_11695	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
N2K98_11700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N2K98_11705	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N2K98_11710	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N2K98_11715	COG0356	it plays a direct role in the translocation of protons across the membrane
N2K98_11730	COG1086	Polysaccharide biosynthesis protein
N2K98_11755	COG2890	protein-(glutamine-N5) methyltransferase activity
N2K98_11760	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N2K98_11770	COG0083	homoserine kinase activity
N2K98_11775	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N2K98_11780	COG0460	homoserine dehydrogenase
N2K98_11790	COG0018	arginyl-trna synthetase
N2K98_11805	COG0633	Ferredoxin
N2K98_11805	COG0543	2 iron, 2 sulfur cluster binding
N2K98_11845	COG0559	Belongs to the binding-protein-dependent transport system permease family
N2K98_11880	COG1643	Atp-dependent helicase
N2K98_11885	COG0537	adenosine 5'-monophosphoramidase activity
N2K98_11910	COG1121	(ABC) transporter
N2K98_11925	COG1253	flavin adenine dinucleotide binding
N2K98_11930	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2K98_11930	COG0567	Dehydrogenase, E1 component
N2K98_11950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N2K98_11955	COG4172	Belongs to the ABC transporter superfamily
N2K98_11965	COG1024	Enoyl-CoA hydratase
N2K98_11985	COG1960	acyl-CoA dehydrogenase activity
N2K98_11995	COG1595	DNA-templated transcription, initiation
N2K98_12005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N2K98_12015	COG0483	inositol monophosphate 1-phosphatase activity
N2K98_12025	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N2K98_12030	COG0366	Alpha amylase catalytic
N2K98_12060	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N2K98_12070	COG2177	Part of the ABC transporter FtsEX involved in
N2K98_12075	COG2884	Cell division ATP-binding protein ftsE
N2K98_12080	COG2755	lipolytic protein G-D-S-L family
N2K98_12080	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N2K98_12085	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N2K98_12095	COG1215	transferase activity, transferring glycosyl groups
N2K98_12160	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
N2K98_12165	COG1088	dTDP-glucose 4,6-dehydratase activity
N2K98_12180	COG1215	transferase activity, transferring glycosyl groups
N2K98_12195	COG0463	Glycosyl transferase, family 2
N2K98_12210	COG1216	Glycosyl transferase, family 2
N2K98_12220	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N2K98_12220	COG2755	lipolytic protein G-D-S-L family
N2K98_12225	COG0433	COG0433 Predicted ATPase
N2K98_12225	COG1674	ftsk spoiiie
N2K98_12245	COG2902	Dehydrogenase
N2K98_12280	COG0653	protein targeting
N2K98_12285	COG3214	Protein conserved in bacteria
N2K98_12290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N2K98_12295	COG1040	competence protein
N2K98_12300	COG5401	PFAM Sporulation and spore germination
N2K98_12305	COG5002	protein histidine kinase activity
N2K98_12310	COG0745	RESPONSE REGULATOR receiver
N2K98_12330	COG0714	Associated with various cellular activities
N2K98_12355	COG0482	sulfurtransferase activity
N2K98_12385	COG0484	heat shock protein binding
N2K98_12390	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N2K98_12395	COG2226	methyltransferase
N2K98_12405	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
N2K98_12415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N2K98_12430	COG1842	Phage shock protein A
N2K98_12445	COG1615	UPF0182 protein
N2K98_12450	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N2K98_12490	COG1131	(ABC) transporter
N2K98_12500	COG0210	DNA helicase
N2K98_12525	COG2011	ABC-type metal ion transport system permease component
N2K98_12535	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N2K98_12540	COG0113	porphobilinogen synthase activity
N2K98_12550	COG0181	hydroxymethylbilane synthase activity
N2K98_12555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N2K98_12560	COG3253	May function as heme-dependent peroxidase
N2K98_12570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N2K98_12575	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N2K98_12610	COG0513	Belongs to the DEAD box helicase family
N2K98_12620	COG0613	PHP domain protein
N2K98_12625	COG0006	proline dipeptidase activity
N2K98_12635	COG2239	Acts as a magnesium transporter
N2K98_12650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N2K98_12660	COG1595	DNA-templated transcription, initiation
N2K98_12670	COG0024	Methionine aminopeptidase
N2K98_12675	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N2K98_12690	COG0519	Catalyzes the synthesis of GMP from XMP
N2K98_12700	COG1611	Belongs to the LOG family
N2K98_12705	COG1126	abc transporter atp-binding protein
N2K98_12710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N2K98_12715	COG0765	amino acid transport
N2K98_12720	COG0765	amino acid transport
N2K98_12725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N2K98_12730	COG2171	N-acyltransferase activity
N2K98_12740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N2K98_12770	COG1217	gtp-binding protein TYPA
N2K98_12780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N2K98_12785	COG0601	transmembrane transport
N2K98_12845	COG0012	GTP binding
N2K98_12850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N2K98_12860	COG1570	exodeoxyribonuclease VII activity
N2K98_12865	COG1722	exodeoxyribonuclease VII activity
N2K98_12895	COG0494	nUDIX hydrolase
N2K98_12900	COG2971	BadF BadG BcrA BcrD
N2K98_12925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N2K98_12930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N2K98_12935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N2K98_12960	COG0519	Catalyzes the synthesis of GMP from XMP
N2K98_12960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N2K98_12980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N2K98_12985	COG0516	GMP reductase activity
N2K98_12995	COG0459	protein refolding
N2K98_13000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N2K98_13010	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2K98_13015	COG4605	iron ion homeostasis
N2K98_13020	COG4604	ABC transporter, ATP-binding protein
N2K98_13055	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
N2K98_13065	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N2K98_13070	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
N2K98_13075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N2K98_13095	COG0802	atpase or kinase
N2K98_13100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N2K98_13110	COG0667	Aldo Keto reductase
N2K98_13120	COG0800	Aldolase
N2K98_13125	COG2721	sulfolactate sulfo-lyase activity
N2K98_13130	COG4948	Mandelate Racemase Muconate Lactonizing
N2K98_13135	COG1904	glucuronate isomerase
N2K98_13150	COG3842	ATPase activity
N2K98_13160	COG4149	molybdate abc transporter
N2K98_13165	COG0246	Mannitol dehydrogenase
N2K98_13190	COG0736	holo-[acyl-carrier-protein] synthase activity
N2K98_13200	COG1072	(Pantothenic acid kinase))
N2K98_13205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N2K98_13210	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N2K98_13215	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N2K98_13220	COG0101	tRNA pseudouridine synthase activity
N2K98_13225	COG0203	ribosomal protein L17
N2K98_13230	COG0202	RNA polymerase activity
N2K98_13235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N2K98_13240	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N2K98_13245	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N2K98_13250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N2K98_13255	COG0024	Methionine aminopeptidase
N2K98_13260	COG0563	adenylate kinase activity
N2K98_13270	COG0200	Binds to the 23S rRNA
N2K98_13275	COG1841	ribosomal large subunit assembly
N2K98_13280	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N2K98_13290	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N2K98_13295	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N2K98_13300	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N2K98_13305	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N2K98_13310	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N2K98_13315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N2K98_13325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N2K98_13330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N2K98_13335	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N2K98_13340	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N2K98_13345	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N2K98_13350	COG0089	rRNA binding
N2K98_13355	COG0088	Forms part of the polypeptide exit tunnel
N2K98_13360	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N2K98_13365	COG0051	transcription antitermination factor activity, RNA binding
N2K98_13385	COG0318	PFAM AMP-dependent synthetase and ligase
N2K98_13395	COG1902	pentaerythritol trinitrate reductase activity
N2K98_13395	COG0446	pyridine nucleotide-disulphide oxidoreductase
N2K98_13400	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N2K98_13405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N2K98_13410	COG0049	tRNA binding
N2K98_13415	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N2K98_13420	COG1414	Transcriptional regulator
N2K98_13425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
N2K98_13435	COG0183	Belongs to the thiolase family
N2K98_13440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N2K98_13455	COG3485	protocatechuate 3,4-dioxygenase
N2K98_13460	COG3485	protocatechuate 3,4-dioxygenase
N2K98_13480	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N2K98_13485	COG0085	RNA polymerase activity
N2K98_13495	COG0222	ribosome binding
N2K98_13500	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N2K98_13510	COG0081	regulation of translation
N2K98_13515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N2K98_13525	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N2K98_13535	COG0436	Aminotransferase
N2K98_13540	COG2197	response regulator
N2K98_13585	COG3485	protocatechuate 3,4-dioxygenase
N2K98_13595	COG0745	RESPONSE REGULATOR receiver
N2K98_13600	COG0456	acetyltransferase
N2K98_13605	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N2K98_13615	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
N2K98_13620	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N2K98_13625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N2K98_13635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N2K98_13645	COG2030	dehydratase
N2K98_13660	COG0693	protein deglycase activity
N2K98_13675	COG0515	serine threonine protein kinase
N2K98_13675	COG2815	serine threonine protein kinase
N2K98_13690	COG5650	phosphatidylinositol metabolic process
N2K98_13695	COG0402	S-adenosylhomocysteine deaminase activity
N2K98_13720	COG0318	PFAM AMP-dependent synthetase and ligase
N2K98_13735	COG1063	alcohol dehydrogenase
N2K98_13740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N2K98_13760	COG1666	GTP binding
N2K98_13765	COG0406	alpha-ribazole phosphatase activity
N2K98_13770	COG0501	Belongs to the peptidase M48B family
N2K98_13780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N2K98_13820	COG1233	COG1233 Phytoene dehydrogenase and related
N2K98_13830	COG0142	geranyltranstransferase activity
N2K98_13835	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
N2K98_13840	COG0463	Glycosyl transferase, family 2
N2K98_13920	COG1012	belongs to the aldehyde dehydrogenase family
N2K98_13940	COG0537	adenosine 5'-monophosphoramidase activity
N2K98_13945	COG0142	geranyltranstransferase activity
N2K98_13955	COG2226	methyltransferase
N2K98_13970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N2K98_13975	COG0765	amino acid transport
N2K98_13990	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
N2K98_13995	COG4948	Mandelate Racemase Muconate Lactonizing
N2K98_14020	COG0022	dehydrogenase e1 component
N2K98_14030	COG1522	sequence-specific DNA binding
N2K98_14040	COG1024	Enoyl-CoA hydratase
N2K98_14045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
N2K98_14050	COG2151	metal-sulfur cluster biosynthetic enzyme
N2K98_14055	COG3396	Phenylacetate-CoA oxygenase
N2K98_14060	COG3460	Phenylacetate-CoA oxygenase
N2K98_14065	COG3396	Phenylacetate-CoA oxygenase
N2K98_14085	COG2723	6-phospho-beta-galactosidase activity
N2K98_14090	COG0395	ABC-type sugar transport system, permease component
N2K98_14110	COG2050	protein possibly involved in aromatic compounds catabolism
N2K98_14140	COG2030	dehydratase
N2K98_14140	COG1012	belongs to the aldehyde dehydrogenase family
N2K98_14155	COG1793	dna ligase
N2K98_14165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N2K98_14190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N2K98_14215	COG1140	nitrate reductase beta subunit
N2K98_14225	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
N2K98_14255	COG1309	transcriptional regulator
N2K98_14260	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N2K98_14270	COG0785	Cytochrome C biogenesis protein
N2K98_14280	COG0406	alpha-ribazole phosphatase activity
N2K98_14285	COG2353	YceI-like domain
N2K98_14300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
N2K98_14325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N2K98_14330	COG0640	Transcriptional regulator
N2K98_14340	COG1309	transcriptional regulator
N2K98_14345	COG0123	including yeast histone deacetylase and acetoin utilization protein
N2K98_14350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N2K98_14355	COG0569	domain protein
N2K98_14365	COG1082	Xylose isomerase domain protein TIM barrel
N2K98_14370	COG0248	Ppx GppA phosphatase
N2K98_14375	COG1754	DNA topoisomerase type I activity
N2K98_14375	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N2K98_14380	COG2890	protein-(glutamine-N5) methyltransferase activity
N2K98_14385	COG1053	succinate dehydrogenase
N2K98_14390	COG1054	Belongs to the UPF0176 family
N2K98_14400	COG1111	helicase
N2K98_14400	COG1205	dead DEAH box helicase
N2K98_14440	COG2072	flavoprotein involved in K transport
N2K98_14450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N2K98_14450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N2K98_14460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N2K98_14470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N2K98_14475	COG1764	response to oxidative stress
N2K98_14485	COG0477	Major facilitator Superfamily
N2K98_14490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N2K98_14525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N2K98_14530	COG1408	metallophosphoesterase
N2K98_14540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N2K98_14545	COG0151	Belongs to the GarS family
N2K98_14570	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N2K98_14585	COG0542	response to heat
N2K98_14600	COG3304	Inner membrane component domain
N2K98_14615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N2K98_14635	COG0789	Transcriptional regulator
N2K98_14640	COG0484	heat shock protein binding
N2K98_14645	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N2K98_14650	COG0443	Heat shock 70 kDa protein
N2K98_14665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N2K98_14680	COG4172	Belongs to the ABC transporter superfamily
N2K98_14685	COG4721	ABC-type cobalt transport system, permease component
N2K98_14700	COG2212	antiporter activity
N2K98_14705	COG1863	multisubunit Na H antiporter MnhE subunit
N2K98_14710	COG0651	ATP synthesis coupled electron transport
N2K98_14715	COG1006	Multisubunit Na H antiporter MnhC subunit
N2K98_14720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N2K98_14720	COG2111	Na H antiporter
N2K98_14730	COG0717	Belongs to the dCTP deaminase family
N2K98_14735	COG3483	tryptophan 2,3-dioxygenase activity
N2K98_14760	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
N2K98_14800	COG3336	cytochrome c oxidase
N2K98_14805	COG0776	regulation of translation
N2K98_14810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N2K98_14815	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N2K98_14820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N2K98_14825	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N2K98_14835	COG0477	Major facilitator Superfamily
N2K98_14845	COG1597	lipid kinase activity
N2K98_14850	COG0739	heme binding
N2K98_14850	COG0741	lytic transglycosylase activity
N2K98_14850	COG1196	nuclear chromosome segregation
N2K98_14855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2K98_14860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2K98_14875	COG1120	ATPase activity
N2K98_14880	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2K98_14885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2K98_14890	COG0435	Glutathione S-transferase
N2K98_14905	COG1113	amino acid transport
N2K98_14910	COG1295	ribonuclease BN
N2K98_14935	COG2146	nitrite reductase [NAD(P)H] activity
N2K98_14960	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_14965	COG1960	acyl-CoA dehydrogenase activity
N2K98_15000	COG1414	Transcriptional regulator
N2K98_15015	COG1063	alcohol dehydrogenase
N2K98_15035	COG1174	glycine betaine transport
N2K98_15045	COG1174	glycine betaine transport
N2K98_15055	COG0531	amino acid
N2K98_15070	COG1960	acyl-CoA dehydrogenase activity
N2K98_15080	COG0183	Belongs to the thiolase family
N2K98_15085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N2K98_15090	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N2K98_15095	COG0179	Fumarylacetoacetate (FAA) hydrolase
N2K98_15105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N2K98_15115	COG1960	acyl-CoA dehydrogenase activity
N2K98_15160	COG1172	Belongs to the binding-protein-dependent transport system permease family
N2K98_15180	COG1473	amidohydrolase
N2K98_15200	COG4585	Histidine kinase
N2K98_15205	COG2197	response regulator
N2K98_15210	COG4152	abc transporter atp-binding protein
N2K98_15245	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_15250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N2K98_15255	COG1012	belongs to the aldehyde dehydrogenase family
N2K98_15275	COG0318	PFAM AMP-dependent synthetase and ligase
N2K98_15300	COG3971	2-oxopent-4-enoate hydratase activity
N2K98_15320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N2K98_15325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2K98_15330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2K98_15335	COG1116	anion transmembrane transporter activity
N2K98_15345	COG1309	transcriptional regulator
N2K98_15350	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_15355	COG1802	Transcriptional regulator
N2K98_15360	COG0179	Fumarylacetoacetate (FAA) hydrolase
N2K98_15365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N2K98_15375	COG4221	oxidoreductase activity
N2K98_15395	COG0028	Belongs to the TPP enzyme family
N2K98_15405	COG0596	Alpha beta hydrolase
N2K98_15430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2K98_15440	COG1012	belongs to the aldehyde dehydrogenase family
N2K98_15445	COG2860	membrane
N2K98_15455	COG1063	alcohol dehydrogenase
N2K98_15475	COG1072	(Pantothenic acid kinase))
N2K98_15480	COG3386	PFAM SMP-30 Gluconolaconase
N2K98_15485	COG0531	amino acid
N2K98_15515	COG0492	ferredoxin-NADP+ reductase activity
N2K98_15585	COG1414	Transcriptional regulator
N2K98_15590	COG2217	Heavy metal translocating P-type atpase
N2K98_15595	COG0598	Magnesium transport protein CorA
N2K98_15605	COG0477	Major facilitator Superfamily
N2K98_15610	COG3546	catalase activity
N2K98_15620	COG0500	methyltransferase
N2K98_15635	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_15645	COG0477	Major facilitator Superfamily
N2K98_15655	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N2K98_15670	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N2K98_15680	COG3257	ureidoglycine aminohydrolase activity
N2K98_15690	COG2233	PERMEase
N2K98_15715	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
N2K98_15715	COG3608	succinylglutamate desuccinylase aspartoacylase
N2K98_15725	COG1529	Aldehyde oxidase and xanthine dehydrogenase
N2K98_15770	COG5650	phosphatidylinositol metabolic process
N2K98_15785	COG0179	Fumarylacetoacetate (FAA) hydrolase
N2K98_15795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N2K98_15805	COG0179	Fumarylacetoacetate (FAA) hydrolase
N2K98_15815	COG1172	Belongs to the binding-protein-dependent transport system permease family
N2K98_15820	COG1129	ABC transporter
N2K98_15840	COG1846	Transcriptional regulator
N2K98_15850	COG0318	PFAM AMP-dependent synthetase and ligase
N2K98_15865	COG0477	Major facilitator Superfamily
N2K98_15875	COG3971	2-oxopent-4-enoate hydratase activity
N2K98_15885	COG1012	belongs to the aldehyde dehydrogenase family
N2K98_15925	COG1902	pentaerythritol trinitrate reductase activity
N2K98_15930	COG0391	Required for morphogenesis under gluconeogenic growth conditions
N2K98_15935	COG1920	GTP binding
N2K98_15940	COG1733	regulation of RNA biosynthetic process
N2K98_15950	COG0778	Nitroreductase
N2K98_15950	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
N2K98_15955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
N2K98_15965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N2K98_15970	COG1120	ATPase activity
N2K98_15980	COG2314	TM2 domain
N2K98_15990	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_16050	COG1309	transcriptional regulator
N2K98_16080	COG1126	abc transporter atp-binding protein
N2K98_16085	COG2076	Multidrug Resistance protein
N2K98_16105	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_16115	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_16130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N2K98_16145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N2K98_16175	COG0656	L-ascorbic acid biosynthetic process
N2K98_16215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N2K98_16235	COG1937	Protein conserved in bacteria
N2K98_16255	COG0477	Major facilitator Superfamily
N2K98_16270	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N2K98_16280	COG1132	(ABC) transporter
N2K98_16300	COG2814	Major facilitator Superfamily
N2K98_16305	COG2409	Drug exporters of the RND superfamily
N2K98_16315	COG0702	epimerase
N2K98_16320	COG0667	Aldo Keto reductase
N2K98_16330	COG0277	FAD linked oxidase domain protein
N2K98_16335	COG1620	l-lactate permease
N2K98_16340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
N2K98_16345	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_16355	COG1115	amino acid carrier protein
N2K98_16370	COG0509	glycine decarboxylation via glycine cleavage system
N2K98_16375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N2K98_16380	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N2K98_16380	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
N2K98_16385	COG1113	amino acid transport
N2K98_16420	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
N2K98_16440	COG0686	Belongs to the AlaDH PNT family
N2K98_16455	COG1309	transcriptional regulator
N2K98_16480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N2K98_16485	COG0508	dehydrogenase complex catalyzes the overall conversion of
N2K98_16490	COG0022	dehydrogenase e1 component
N2K98_16500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N2K98_16505	COG1950	PFAM Membrane protein of
N2K98_16520	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N2K98_16525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N2K98_16535	COG0590	tRNA wobble adenosine to inosine editing
N2K98_16545	COG0395	ABC-type sugar transport system, permease component
N2K98_16550	COG1175	transmembrane transport
N2K98_16575	COG0246	Mannitol dehydrogenase
N2K98_16605	COG2197	response regulator
N2K98_16620	COG2205	protein histidine kinase activity
N2K98_16625	COG0745	RESPONSE REGULATOR receiver
N2K98_16635	COG1329	Transcriptional regulator
N2K98_16660	COG1063	alcohol dehydrogenase
N2K98_16665	COG5002	protein histidine kinase activity
N2K98_16680	COG0246	Mannitol dehydrogenase
N2K98_16710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N2K98_16715	COG1595	DNA-templated transcription, initiation
N2K98_16720	COG0318	PFAM AMP-dependent synthetase and ligase
N2K98_16750	COG1191	sigma factor activity
N2K98_16755	COG1619	proteins homologs of microcin C7 resistance protein MccF
N2K98_16765	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N2K98_16780	COG0297	glycogen (starch) synthase activity
N2K98_16785	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N2K98_16790	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N2K98_16790	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N2K98_16795	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_16800	COG0697	spore germination
N2K98_16805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
N2K98_16810	COG3655	Transcriptional regulator
N2K98_16835	COG1940	carbohydrate kinase activity
N2K98_16860	COG1028	Short-chain dehydrogenase reductase Sdr
N2K98_16870	COG1960	acyl-CoA dehydrogenase activity
N2K98_16890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N2K98_16920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N2K98_16920	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N2K98_16925	COG1216	Glycosyl transferase, family 2
N2K98_16945	COG2814	Major facilitator Superfamily
N2K98_16960	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N2K98_16965	COG3583	domain protein
N2K98_16970	COG0531	amino acid
N2K98_16980	COG0305	Participates in initiation and elongation during chromosome replication
N2K98_16985	COG0359	binds to the 23S rRNA
N2K98_16990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N2K98_17000	COG0360	Binds together with S18 to 16S ribosomal RNA
N2K98_17005	COG1362	aminopeptidase activity
N2K98_17035	COG0738	Major facilitator superfamily
N2K98_17040	COG0488	(ABC) transporter
N2K98_17075	COG1260	myo-inositol-1-phosphate synthase
N2K98_17080	COG2759	Belongs to the formate--tetrahydrofolate ligase family
N2K98_17085	COG0438	transferase activity, transferring glycosyl groups
N2K98_17090	COG0406	alpha-ribazole phosphatase activity
N2K98_17095	COG0617	tRNA 3'-terminal CCA addition
N2K98_17115	COG0492	ferredoxin-NADP+ reductase activity
N2K98_17120	COG3118	belongs to the thioredoxin family
N2K98_17125	COG0860	N-Acetylmuramoyl-L-alanine amidase
N2K98_17125	COG3409	Peptidoglycan-binding domain 1 protein
N2K98_17155	COG1192	Involved in chromosome partitioning
N2K98_17160	COG0357	Ribosomal RNA small subunit methyltransferase G
N2K98_17170	COG0706	membrane insertase activity
N2K98_17180	COG0594	ribonuclease P activity
N2K98_17185	COG0230	Belongs to the bacterial ribosomal protein bL34 family