locus-tag	class	description
G8758_00025	COG0577	efflux transmembrane transporter activity
G8758_00025	COG1136	(ABC) transporter
G8758_00030	COG0577	efflux transmembrane transporter activity
G8758_00045	COG3842	ATPase activity
G8758_00110	COG1475	DNA binding
G8758_00330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8758_00335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8758_00350	COG0789	Transcriptional regulator
G8758_00370	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G8758_00375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G8758_00380	COG0509	glycine decarboxylation via glycine cleavage system
G8758_00390	COG0783	Belongs to the Dps family
G8758_00400	COG2957	Belongs to the agmatine deiminase family
G8758_00405	COG0477	Major facilitator Superfamily
G8758_00420	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G8758_00420	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G8758_00425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G8758_00450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G8758_00465	COG0459	protein refolding
G8758_00470	COG0328	RNA-DNA hybrid ribonuclease activity
G8758_00480	COG2205	protein histidine kinase activity
G8758_00485	COG0745	RESPONSE REGULATOR receiver
G8758_00490	COG1278	Cold shock
G8758_00510	COG0739	heme binding
G8758_00530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G8758_00535	COG1132	(ABC) transporter
G8758_00555	COG0494	nUDIX hydrolase
G8758_00570	COG0483	inositol monophosphate 1-phosphatase activity
G8758_00585	COG1316	TRANSCRIPTIONal
G8758_00595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G8758_00600	COG0489	protein tyrosine kinase activity
G8758_00615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G8758_00620	COG0681	Belongs to the peptidase S26 family
G8758_00625	COG2755	lipolytic protein G-D-S-L family
G8758_00625	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G8758_00670	COG0045	succinate-CoA ligase (ADP-forming) activity
G8758_00680	COG3634	alkyl hydroperoxide reductase activity
G8758_00695	COG0028	Belongs to the TPP enzyme family
G8758_00740	COG1396	sequence-specific DNA binding
G8758_00780	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G8758_00810	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
G8758_00815	COG0477	Major facilitator Superfamily
G8758_00825	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
G8758_00835	COG0138	bifunctional purine biosynthesis protein purh
G8758_00840	COG2838	Isocitrate dehydrogenase
G8758_00850	COG0673	inositol 2-dehydrogenase activity
G8758_00855	COG3639	organic phosphonate transmembrane transporter activity
G8758_00860	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G8758_00885	COG4213	ABC transporter substrate-binding protein
G8758_00895	COG1129	ABC transporter
G8758_00900	COG1940	carbohydrate kinase activity
G8758_00915	COG0531	amino acid
G8758_00935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G8758_00940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G8758_00960	COG4585	Histidine kinase
G8758_00965	COG2197	response regulator
G8758_00980	COG0708	Exodeoxyribonuclease III
G8758_00985	COG0180	Tryptophanyl-tRNA synthetase
G8758_01005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G8758_01020	COG2009	succinate dehydrogenase
G8758_01030	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G8758_01030	COG1473	amidohydrolase
G8758_01035	COG1744	ABC transporter substrate-binding protein PnrA-like
G8758_01040	COG3845	ABC transporter
G8758_01045	COG4603	Belongs to the binding-protein-dependent transport system permease family
G8758_01050	COG1079	Belongs to the binding-protein-dependent transport system permease family
G8758_01065	COG0586	Pfam SNARE associated Golgi protein
G8758_01075	COG2264	protein methyltransferase activity
G8758_01080	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G8758_01090	COG0148	phosphopyruvate hydratase activity
G8758_01110	COG1252	NADH dehydrogenase
G8758_01125	COG0656	L-ascorbic acid biosynthetic process
G8758_01130	COG2814	Major facilitator Superfamily
G8758_01135	COG1846	Transcriptional regulator
G8758_01170	COG2017	converts alpha-aldose to the beta-anomer
G8758_01185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G8758_01195	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G8758_01205	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G8758_01215	COG1846	Transcriptional regulator
G8758_01230	COG1331	Highly conserved protein containing a thioredoxin domain
G8758_01250	COG1027	Aspartate ammonia-lyase
G8758_01260	COG2186	Transcriptional regulator
G8758_01265	COG2223	nitrite transmembrane transporter activity
G8758_01280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G8758_01285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G8758_01290	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G8758_01310	COG0114	fumarate hydratase activity
G8758_01315	COG0288	reversible hydration of carbon dioxide
G8758_01345	COG1316	TRANSCRIPTIONal
G8758_01395	COG2835	tetraacyldisaccharide 4'-kinase activity
G8758_01400	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G8758_01420	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
G8758_01445	COG0714	Associated with various cellular activities
G8758_01450	COG0084	hydrolase, TatD family'
G8758_01455	COG3583	domain protein
G8758_01460	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G8758_01465	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G8758_01470	COG0488	(ABC) transporter
G8758_01485	COG1396	sequence-specific DNA binding
G8758_01505	COG1309	transcriptional regulator
G8758_01510	COG1012	belongs to the aldehyde dehydrogenase family
G8758_01510	COG2030	dehydratase
G8758_01515	COG3396	Phenylacetate-CoA oxygenase
G8758_01525	COG3396	Phenylacetate-CoA oxygenase
G8758_01545	COG1024	Enoyl-CoA hydratase
G8758_01550	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8758_01555	COG2050	protein possibly involved in aromatic compounds catabolism
G8758_01560	COG1024	Enoyl-CoA hydratase
G8758_01570	COG2050	protein possibly involved in aromatic compounds catabolism
G8758_01585	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G8758_01590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G8758_01595	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G8758_01600	COG0193	aminoacyl-tRNA hydrolase activity
G8758_01615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G8758_01675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G8758_01680	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
G8758_01690	COG0822	iron-sulfur transferase activity
G8758_01695	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G8758_01705	COG0488	(ABC) transporter
G8758_01715	COG1652	LysM domain
G8758_01730	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G8758_01735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8758_01760	COG0477	Major facilitator Superfamily
G8758_01770	COG4770	biotin carboxylase activity
G8758_01775	COG0424	maF-like protein
G8758_01780	COG0393	Putative heavy-metal-binding
G8758_01785	COG1823	symporter activity
G8758_01820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G8758_01850	COG0714	Associated with various cellular activities
G8758_01860	COG1305	Transglutaminase-like
G8758_01870	COG0631	protein serine/threonine phosphatase activity
G8758_01895	COG1674	ftsk spoiiie
G8758_01900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G8758_01905	COG0483	inositol monophosphate 1-phosphatase activity
G8758_01920	COG4565	transcriptional regulatory protein
G8758_01925	COG5000	phosphorelay sensor kinase activity
G8758_01930	COG2851	Citrate transporter
G8758_01935	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
G8758_01960	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G8758_01965	COG0154	amidase activity
G8758_01970	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G8758_01995	COG4209	transmembrane transport
G8758_02000	COG0395	ABC-type sugar transport system, permease component
G8758_02010	COG1609	Transcriptional regulator
G8758_02020	COG0583	DNA-binding transcription factor activity
G8758_02025	COG1228	amidohydrolase
G8758_02030	COG1063	alcohol dehydrogenase
G8758_02035	COG0156	8-amino-7-oxononanoate synthase activity
G8758_02040	COG1228	amidohydrolase
G8758_02045	COG0366	Alpha amylase catalytic
G8758_02045	COG1470	cell adhesion involved in biofilm formation
G8758_02050	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G8758_02055	COG1940	carbohydrate kinase activity
G8758_02060	COG1105	Belongs to the carbohydrate kinase PfkB family
G8758_02080	COG3473	Maleate cis-trans isomerase
G8758_02115	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G8758_02140	COG2873	o-acetylhomoserine
G8758_02145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8758_02155	COG2755	lipolytic protein G-D-S-L family
G8758_02175	COG0423	glycine-tRNA ligase activity
G8758_02205	COG1131	(ABC) transporter
G8758_02215	COG4585	Histidine kinase
G8758_02220	COG2197	response regulator
G8758_02225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G8758_02235	COG0358	DNA primase activity
G8758_02250	COG1309	transcriptional regulator
G8758_02275	COG2814	Major facilitator Superfamily
G8758_02295	COG0438	transferase activity, transferring glycosyl groups
G8758_02350	COG1028	Short-chain dehydrogenase reductase Sdr
G8758_02355	COG1846	Transcriptional regulator
G8758_02400	COG0052	Belongs to the universal ribosomal protein uS2 family
G8758_02405	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G8758_02410	COG0528	UMP kinase activity
G8758_02415	COG0233	cytoplasmic translational termination
G8758_02430	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G8758_02445	COG3275	phosphorelay sensor kinase activity
G8758_02455	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G8758_02460	COG2814	Major facilitator Superfamily
G8758_02475	COG0022	dehydrogenase e1 component
G8758_02480	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8758_02490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G8758_02500	COG1960	acyl-CoA dehydrogenase activity
G8758_02510	COG2030	dehydratase
G8758_02520	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G8758_02525	COG0750	zinc metalloprotease
G8758_02535	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G8758_02540	COG0456	acetyltransferase
G8758_02565	COG1131	(ABC) transporter
G8758_02575	COG0442	prolyl-tRNA aminoacylation
G8758_02600	COG0779	Required for maturation of 30S ribosomal subunits
G8758_02615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G8758_02620	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G8758_02630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G8758_02655	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G8758_02660	COG1185	polyribonucleotide nucleotidyltransferase activity
G8758_02665	COG0612	Peptidase, M16
G8758_02680	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G8758_02690	COG0315	cyclic pyranopterin monophosphate synthase activity
G8758_02695	COG0521	Mo-molybdopterin cofactor biosynthetic process
G8758_02705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G8758_02715	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G8758_02720	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G8758_02725	COG1674	ftsk spoiiie
G8758_02735	COG1058	Belongs to the CinA family
G8758_02735	COG1546	Belongs to the CinA family
G8758_02740	COG1396	sequence-specific DNA binding
G8758_02755	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G8758_02760	COG2137	regulation of response to DNA damage stimulus
G8758_02765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G8758_02770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G8758_02775	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G8758_02780	COG2813	Specifically methylates the guanine in position
G8758_02785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G8758_02795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G8758_02800	COG1388	LysM domain
G8758_02805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G8758_02810	COG0131	Imidazoleglycerol-phosphate dehydratase
G8758_02815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G8758_02825	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G8758_02845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G8758_02850	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G8758_02855	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G8758_02860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8758_02870	COG2814	Major facilitator Superfamily
G8758_02875	COG0494	nUDIX hydrolase
G8758_02895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G8758_02900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8758_02900	COG0072	phenylalanine-tRNA ligase activity
G8758_02910	COG2326	polyphosphate kinase activity
G8758_02935	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G8758_02940	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G8758_02945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G8758_02950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G8758_02955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G8758_02960	COG1438	arginine binding
G8758_02965	COG0577	efflux transmembrane transporter activity
G8758_02965	COG1136	(ABC) transporter
G8758_02990	COG0137	argininosuccinate synthase activity
G8758_02995	COG0165	Argininosuccinate lyase
G8758_03005	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G8758_03005	COG2169	Transcriptional regulator
G8758_03015	COG2094	Belongs to the DNA glycosylase MPG family
G8758_03020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G8758_03025	COG3973	AAA domain
G8758_03030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G8758_03060	COG1012	belongs to the aldehyde dehydrogenase family
G8758_03065	COG1960	acyl-CoA dehydrogenase activity
G8758_03080	COG0531	amino acid
G8758_03090	COG0647	UMP catabolic process
G8758_03105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G8758_03110	COG0497	DNA recombination
G8758_03115	COG0504	CTP synthase activity
G8758_03155	COG0019	diaminopimelate decarboxylase activity
G8758_03170	COG0640	Transcriptional regulator
G8758_03180	COG0384	phenazine biosynthesis protein PhzF
G8758_03185	COG1522	sequence-specific DNA binding
G8758_03195	COG1121	(ABC) transporter
G8758_03220	COG2816	NAD+ diphosphatase activity
G8758_03230	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
G8758_03235	COG2079	MmgE PrpD family protein
G8758_03250	COG4565	transcriptional regulatory protein
G8758_03255	COG3290	protein histidine kinase activity
G8758_03260	COG1301	dicarboxylic acid transport
G8758_03275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G8758_03295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G8758_03305	COG1160	GTP binding
G8758_03325	COG1309	transcriptional regulator
G8758_03360	COG1522	sequence-specific DNA binding
G8758_03370	COG0022	dehydrogenase e1 component
G8758_03375	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8758_03380	COG0646	methionine synthase
G8758_03380	COG1410	methionine synthase
G8758_03400	COG1366	Belongs to the anti-sigma-factor antagonist family
G8758_03405	COG1215	transferase activity, transferring glycosyl groups
G8758_03415	COG0583	DNA-binding transcription factor activity
G8758_03420	COG2814	Major facilitator Superfamily
G8758_03450	COG3795	YCII-related domain
G8758_03475	COG1278	Cold shock
G8758_03490	COG2197	response regulator
G8758_03495	COG4585	Histidine kinase
G8758_03525	COG0746	molybdenum cofactor guanylyltransferase activity
G8758_03535	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G8758_03550	COG0243	molybdopterin cofactor binding
G8758_03570	COG0531	amino acid
G8758_03575	COG0402	S-adenosylhomocysteine deaminase activity
G8758_03605	COG1574	metal-dependent hydrolase with the TIM-barrel fold
G8758_03615	COG1802	Transcriptional regulator
G8758_03620	COG0402	S-adenosylhomocysteine deaminase activity
G8758_03630	COG0509	glycine decarboxylation via glycine cleavage system
G8758_03635	COG1716	ATPase activity
G8758_03640	COG0789	Transcriptional regulator
G8758_03655	COG1192	Involved in chromosome partitioning
G8758_03665	COG1022	Amp-dependent synthetase and ligase
G8758_03670	COG1940	carbohydrate kinase activity
G8758_03685	COG0204	Acyl-transferase
G8758_03690	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G8758_03695	COG1132	(ABC) transporter
G8758_03705	COG0515	serine threonine protein kinase
G8758_03705	COG2815	serine threonine protein kinase
G8758_03710	COG1388	LysM domain
G8758_03710	COG1705	Flagellar rod assembly protein muramidase FlgJ
G8758_03720	COG0142	geranyltranstransferase activity
G8758_03730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G8758_03740	COG2001	Belongs to the MraZ family
G8758_03745	COG0275	rRNA processing
G8758_03755	COG0768	penicillin binding
G8758_03770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G8758_03775	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G8758_03785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G8758_03790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G8758_03795	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G8758_03800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G8758_03805	COG1496	oxidoreductase activity
G8758_03810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G8758_03815	COG1799	cell septum assembly
G8758_03830	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G8758_03840	COG0587	DNA-directed DNA polymerase activity
G8758_03845	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G8758_03850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G8758_03870	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G8758_03875	COG0174	glutamine synthetase
G8758_03880	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G8758_03885	COG0765	amino acid transport
G8758_03890	COG1126	abc transporter atp-binding protein
G8758_04035	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G8758_04040	COG0321	lipoyl(octanoyl) transferase activity
G8758_04045	COG0515	serine threonine protein kinase
G8758_04045	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G8758_04050	COG4946	Tricorn protease homolog
G8758_04050	COG0793	Belongs to the peptidase S41A family
G8758_04060	COG1764	response to oxidative stress
G8758_04075	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8758_04080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8758_04085	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G8758_04105	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G8758_04110	COG2365	Tyrosine phosphatase family
G8758_04130	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G8758_04150	COG1780	Probably involved in ribonucleotide reductase function
G8758_04155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G8758_04160	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G8758_04210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G8758_04220	COG0506	proline dehydrogenase activity
G8758_04240	COG0583	DNA-binding transcription factor activity
G8758_04285	COG4552	Acetyltransferase involved in intracellular survival and related
G8758_04295	COG0539	negative regulation of cytoplasmic translation
G8758_04310	COG1404	Belongs to the peptidase S8 family
G8758_04315	COG1739	Uncharacterized protein family UPF0029
G8758_04320	COG0237	dephospho-CoA kinase activity
G8758_04320	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
G8758_04325	COG0556	nucleotide-excision repair
G8758_04350	COG4106	trans-aconitate 2-methyltransferase activity
G8758_04370	COG0546	phosphoglycolate phosphatase activity
G8758_04375	COG0204	Acyl-transferase
G8758_04375	COG0318	PFAM AMP-dependent synthetase and ligase
G8758_04380	COG0322	excinuclease ABC activity
G8758_04385	COG1660	Displays ATPase and GTPase activities
G8758_04390	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G8758_04395	COG1481	regulation of sporulation
G8758_04400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G8758_04405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G8758_04410	COG0126	phosphoglycerate kinase activity
G8758_04415	COG0149	triose-phosphate isomerase activity
G8758_04420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G8758_04425	COG0363	glucosamine-6-phosphate deaminase activity
G8758_04440	COG0166	Belongs to the GPI family
G8758_04445	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G8758_04455	COG0109	protoheme IX farnesyltransferase activity
G8758_04460	COG1612	heme a metabolic process
G8758_04470	COG1131	(ABC) transporter
G8758_04495	COG0396	ATPase activity
G8758_04500	COG2151	metal-sulfur cluster biosynthetic enzyme
G8758_04505	COG0442	prolyl-tRNA aminoacylation
G8758_04510	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G8758_04515	COG0477	Major facilitator Superfamily
G8758_04525	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G8758_04535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G8758_04540	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
G8758_04545	COG1116	anion transmembrane transporter activity
G8758_04550	COG0339	signal peptide processing
G8758_04560	COG0367	asparagine synthase
G8758_04565	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
G8758_04570	COG0217	transcriptional regulatory protein
G8758_04575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G8758_04580	COG0632	four-way junction helicase activity
G8758_04585	COG2255	four-way junction helicase activity
G8758_04595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G8758_04600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G8758_04605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G8758_04615	COG1196	nuclear chromosome segregation
G8758_04625	COG0124	histidyl-tRNA synthetase
G8758_04630	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G8758_04645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G8758_04660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G8758_04665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G8758_04675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G8758_04680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G8758_04685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G8758_04690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G8758_04700	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G8758_04705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G8758_04715	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G8758_04720	COG0540	Belongs to the ATCase OTCase family
G8758_04725	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G8758_04735	COG0505	Belongs to the CarA family
G8758_04740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G8758_04745	COG0284	orotidine-5'-phosphate decarboxylase activity
G8758_04750	COG0194	GDP metabolic process
G8758_04755	COG0194	GDP metabolic process
G8758_04760	COG1758	RNA polymerase activity
G8758_04770	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G8758_04785	COG2267	carboxylic ester hydrolase activity
G8758_04790	COG0656	L-ascorbic acid biosynthetic process
G8758_04800	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G8758_04805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G8758_04810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G8758_04815	COG0495	leucyl-tRNA aminoacylation
G8758_04820	COG1307	EDD domain protein, DegV family
G8758_04825	COG2183	response to ionizing radiation
G8758_04845	COG0268	Binds directly to 16S ribosomal RNA
G8758_04855	COG0481	GTPase activity
G8758_04875	COG1420	regulation of RNA biosynthetic process
G8758_04880	COG0484	heat shock protein binding
G8758_04900	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G8758_04910	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G8758_04920	COG3590	peptidase
G8758_04925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G8758_04930	COG1381	Involved in DNA repair and RecF pathway recombination
G8758_04935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G8758_04950	COG0167	dihydroorotate dehydrogenase activity
G8758_04970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G8758_04975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G8758_04995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G8758_05000	COG0723	plastoquinol--plastocyanin reductase activity
G8758_05005	COG2010	Cytochrome c
G8758_05010	COG1845	cytochrome c oxidase, subunit III
G8758_05015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G8758_05040	COG0768	penicillin binding
G8758_05085	COG0058	SHG alpha-glucan phosphorylase activity
G8758_05160	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G8758_05170	COG2855	membrane
G8758_05185	COG0242	peptide deformylase activity
G8758_05210	COG1216	Glycosyl transferase, family 2
G8758_05215	COG1574	metal-dependent hydrolase with the TIM-barrel fold
G8758_05220	COG4581	dead DEAH box helicase
G8758_05225	COG0805	protein transport
G8758_05230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G8758_05240	COG2378	regulation of single-species biofilm formation
G8758_05250	COG0545	Peptidyl-prolyl cis-trans isomerase
G8758_05255	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
G8758_05260	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
G8758_05265	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
G8758_05275	COG4122	O-methyltransferase activity
G8758_05280	COG1222	aaa ATPase
G8758_05295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G8758_05305	COG0215	cysteine-tRNA ligase activity
G8758_05310	COG1968	undecaprenyl-diphosphatase activity
G8758_05320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8758_05340	COG3973	AAA domain
G8758_05360	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G8758_05370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G8758_05500	COG0469	pyruvate kinase activity
G8758_05510	COG0070	glutamate synthase
G8758_05510	COG0067	glutamate synthase
G8758_05510	COG0069	glutamate synthase activity
G8758_05515	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G8758_05520	COG0159	tryptophan synthase activity
G8758_05525	COG0133	tryptophan synthase activity
G8758_05530	COG0134	indole-3-glycerol-phosphate synthase activity
G8758_05550	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G8758_05560	COG0107	imidazoleglycerol-phosphate synthase activity
G8758_05565	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G8758_05570	COG0140	phosphoribosyl-ATP diphosphatase activity
G8758_05575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G8758_05580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G8758_05580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G8758_05585	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G8758_05585	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G8758_05605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G8758_05615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G8758_05620	COG0242	peptide deformylase activity
G8758_05700	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8758_05725	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
G8758_05730	COG0183	Belongs to the thiolase family
G8758_05735	COG1024	Enoyl-CoA hydratase
G8758_05735	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8758_05740	COG0667	Aldo Keto reductase
G8758_05755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G8758_05760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G8758_05770	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G8758_05775	COG0531	amino acid
G8758_05780	COG0569	domain protein
G8758_05805	COG0756	dUTP diphosphatase activity
G8758_05840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G8758_05855	COG4988	ABC transporter
G8758_05860	COG1294	oxidase, subunit
G8758_05865	COG1271	oxidase subunit
G8758_05895	COG1028	Short-chain dehydrogenase reductase Sdr
G8758_05900	COG0183	Belongs to the thiolase family
G8758_05915	COG0297	glycogen (starch) synthase activity
G8758_05920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G8758_05935	COG3340	Belongs to the peptidase S51 family
G8758_05945	COG0254	rRNA binding
G8758_05965	COG1119	ATPase activity
G8758_05970	COG0560	Phosphoserine phosphatase
G8758_05970	COG3830	Belongs to the UPF0237 family
G8758_05975	COG1028	Short-chain dehydrogenase reductase Sdr
G8758_05980	COG1028	Short-chain dehydrogenase reductase Sdr
G8758_06000	COG0488	(ABC) transporter
G8758_06005	COG1268	BioY protein
G8758_06010	COG1122	ATPase activity
G8758_06015	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G8758_06025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G8758_06030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G8758_06050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G8758_06070	COG0009	L-threonylcarbamoyladenylate synthase
G8758_06085	COG1012	belongs to the aldehyde dehydrogenase family
G8758_06115	COG0673	inositol 2-dehydrogenase activity
G8758_06130	COG1940	carbohydrate kinase activity
G8758_06135	COG0673	inositol 2-dehydrogenase activity
G8758_06145	COG2610	gluconate transmembrane transporter activity
G8758_06150	COG0800	Aldolase
G8758_06155	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G8758_06170	COG1414	Transcriptional regulator
G8758_06190	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
G8758_06195	COG0829	nickel cation binding
G8758_06200	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G8758_06205	COG0830	nickel cation binding
G8758_06210	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
G8758_06215	COG0804	urea catabolic process
G8758_06220	COG0831	urea catabolic process
G8758_06230	COG1263	PTS System
G8758_06230	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8758_06230	COG2190	(PTS) system
G8758_06240	COG3711	transcriptional antiterminator
G8758_06245	COG0561	phosphatase activity
G8758_06260	COG1940	carbohydrate kinase activity
G8758_06270	COG1653	transport
G8758_06280	COG0395	ABC-type sugar transport system, permease component
G8758_06310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8758_06315	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
G8758_06335	COG2205	protein histidine kinase activity
G8758_06340	COG0745	RESPONSE REGULATOR receiver
G8758_06355	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G8758_06360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8758_06380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G8758_06385	COG0318	PFAM AMP-dependent synthetase and ligase
G8758_06400	COG3842	ATPase activity
G8758_06405	COG2205	protein histidine kinase activity
G8758_06415	COG0671	phosphoesterase, PA-phosphatase related
G8758_06425	COG1028	Short-chain dehydrogenase reductase Sdr
G8758_06435	COG0596	Alpha beta hydrolase
G8758_06460	COG1609	Transcriptional regulator
G8758_06490	COG1846	Transcriptional regulator
G8758_06495	COG1764	response to oxidative stress
G8758_06505	COG2130	NADP-dependent
G8758_06515	COG4608	Belongs to the ABC transporter superfamily
G8758_06540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G8758_06550	COG2824	Alkylphosphonate utilization operon protein PhnA
G8758_06555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8758_06560	COG1309	transcriptional regulator
G8758_06565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8758_06570	COG0765	amino acid transport
G8758_06575	COG1126	abc transporter atp-binding protein
G8758_06595	COG1012	belongs to the aldehyde dehydrogenase family
G8758_06610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G8758_06630	COG0799	negative regulation of ribosome biogenesis
G8758_06640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G8758_06650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G8758_06655	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G8758_06660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G8758_06665	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G8758_06670	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G8758_06675	COG0352	thiamine-phosphate diphosphorylase activity
G8758_06675	COG0351	phosphomethylpyrimidine kinase
G8758_06675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G8758_06680	COG1530	ribonuclease E activity
G8758_06700	COG0285	dihydrofolate synthase activity
G8758_06705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G8758_06725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G8758_06730	COG3189	MarR family transcriptional regulator
G8758_06735	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G8758_06740	COG0525	valine-tRNA ligase activity
G8758_06745	COG1162	GTPase activity
G8758_06750	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G8758_06755	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G8758_06760	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G8758_06765	COG0740	serine-type endopeptidase activity
G8758_06770	COG0740	serine-type endopeptidase activity
G8758_06775	COG0544	peptidyl-prolyl cis-trans isomerase activity
G8758_06820	COG0668	transmembrane transport
G8758_06840	COG1946	Acyl-CoA thioesterase
G8758_06855	COG0629	single-stranded DNA binding
G8758_06980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G8758_06990	COG0477	Major facilitator Superfamily
G8758_07040	COG0242	peptide deformylase activity
G8758_07050	COG0583	DNA-binding transcription factor activity
G8758_07080	COG3022	response to hydroperoxide
G8758_07095	COG0640	Transcriptional regulator
G8758_07100	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G8758_07105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8758_07115	COG1045	serine acetyltransferase
G8758_07125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G8758_07135	COG2261	transglycosylase associated protein
G8758_07140	COG2808	Putative FMN-binding domain
G8758_07150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8758_07155	COG4106	trans-aconitate 2-methyltransferase activity
G8758_07160	COG0561	phosphatase activity
G8758_07190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G8758_07200	COG4175	Glycine betaine
G8758_07200	COG0517	IMP dehydrogenase activity
G8758_07205	COG4176	ABC-type proline glycine betaine transport system permease component
G8758_07215	COG1063	alcohol dehydrogenase
G8758_07230	COG1012	belongs to the aldehyde dehydrogenase family
G8758_07260	COG0583	DNA-binding transcription factor activity
G8758_07295	COG0657	acetylesterase activity
G8758_07335	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G8758_07350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G8758_07355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G8758_07360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G8758_07370	COG4974	Belongs to the 'phage' integrase family
G8758_07385	COG0792	nuclease activity
G8758_07400	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G8758_07410	COG0681	Belongs to the peptidase S26 family
G8758_07415	COG0335	large ribosomal subunit rRNA binding
G8758_07420	COG0336	Belongs to the RNA methyltransferase TrmD family
G8758_07425	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G8758_07430	COG1837	Belongs to the UPF0109 family
G8758_07435	COG0228	four-way junction DNA binding
G8758_07440	COG0640	Transcriptional regulator
G8758_07455	COG2514	catechol 2,3-dioxygenase activity
G8758_07480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G8758_07510	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G8758_07515	COG0571	ribonuclease III activity
G8758_07520	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G8758_07530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G8758_07550	COG0742	ribosomal rna small subunit methyltransferase
G8758_07560	COG1461	Dihydroxyacetone kinase
G8758_07565	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G8758_07595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
G8758_07600	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
G8758_07605	COG1216	Glycosyl transferase, family 2
G8758_07610	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G8758_07620	COG1134	teichoic acid transport
G8758_07655	COG1181	Belongs to the D-alanine--D-alanine ligase family
G8758_07660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G8758_07670	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G8758_07675	COG1940	carbohydrate kinase activity
G8758_07685	COG1175	transmembrane transport
G8758_07690	COG0395	ABC-type sugar transport system, permease component
G8758_07695	COG0366	Alpha amylase catalytic
G8758_07700	COG0366	Alpha amylase catalytic
G8758_07705	COG0066	3-isopropylmalate dehydratase activity
G8758_07710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G8758_07715	COG1414	Transcriptional regulator
G8758_07740	COG1011	Hydrolase
G8758_07745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G8758_07750	COG0179	Fumarylacetoacetate (FAA) hydrolase
G8758_07770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G8758_07775	COG0473	3-isopropylmalate dehydrogenase activity
G8758_07780	COG4585	Histidine kinase
G8758_07785	COG2197	response regulator
G8758_07790	COG1136	(ABC) transporter
G8758_07790	COG0577	efflux transmembrane transporter activity
G8758_07795	COG0577	efflux transmembrane transporter activity
G8758_07795	COG1136	(ABC) transporter
G8758_07805	COG0577	efflux transmembrane transporter activity
G8758_07805	COG1136	(ABC) transporter
G8758_07815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G8758_07820	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G8758_07825	COG0440	acetolactate synthase activity
G8758_07835	COG0129	dihydroxy-acid dehydratase activity
G8758_07875	COG0747	negative chemotaxis
G8758_07880	COG0579	oxidoreductase
G8758_07885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G8758_07925	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G8758_07930	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G8758_07975	COG2149	membrane
G8758_07995	COG1131	(ABC) transporter
G8758_08005	COG0586	Pfam SNARE associated Golgi protein
G8758_08010	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G8758_08015	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G8758_08020	COG1234	tRNA 3'-trailer cleavage
G8758_08025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G8758_08035	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G8758_08045	COG1335	isochorismatase
G8758_08060	COG0363	glucosamine-6-phosphate deaminase activity
G8758_08105	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
G8758_08110	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G8758_08120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G8758_08125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G8758_08130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G8758_08135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G8758_08140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G8758_08145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G8758_08150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G8758_08155	COG0356	it plays a direct role in the translocation of protons across the membrane
G8758_08170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G8758_08175	COG1086	Polysaccharide biosynthesis protein
G8758_08200	COG2890	protein-(glutamine-N5) methyltransferase activity
G8758_08205	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G8758_08215	COG0083	homoserine kinase activity
G8758_08220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G8758_08225	COG0460	homoserine dehydrogenase
G8758_08230	COG0019	diaminopimelate decarboxylase activity
G8758_08235	COG0018	arginyl-trna synthetase
G8758_08250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G8758_08250	COG1017	nitric oxide dioxygenase activity
G8758_08260	COG1643	Atp-dependent helicase
G8758_08265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G8758_08270	COG0537	adenosine 5'-monophosphoramidase activity
G8758_08275	COG1064	alcohol dehydrogenase
G8758_08280	COG0583	DNA-binding transcription factor activity
G8758_08285	COG0477	Major facilitator Superfamily
G8758_08290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8758_08295	COG0154	amidase activity
G8758_08315	COG0656	L-ascorbic acid biosynthetic process
G8758_08325	COG0477	Major facilitator Superfamily
G8758_08330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G8758_08335	COG1120	ATPase activity
G8758_08350	COG1253	flavin adenine dinucleotide binding
G8758_08355	COG0567	Dehydrogenase, E1 component
G8758_08355	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8758_08385	COG1595	DNA-templated transcription, initiation
G8758_08395	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G8758_08405	COG0483	inositol monophosphate 1-phosphatase activity
G8758_08410	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G8758_08415	COG2226	methyltransferase
G8758_08425	COG1321	iron dependent repressor
G8758_08445	COG2190	(PTS) system
G8758_08445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8758_08445	COG1263	PTS System
G8758_08450	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G8758_08460	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G8758_08475	COG2884	Cell division ATP-binding protein ftsE
G8758_08480	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G8758_08545	COG1132	(ABC) transporter
G8758_08610	COG1216	Glycosyl transferase, family 2
G8758_08620	COG1674	ftsk spoiiie
G8758_08640	COG2902	Dehydrogenase
G8758_08680	COG0653	protein targeting
G8758_08685	COG3214	Protein conserved in bacteria
G8758_08690	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G8758_08695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G8758_08700	COG5401	PFAM Sporulation and spore germination
G8758_08705	COG5002	protein histidine kinase activity
G8758_08710	COG0745	RESPONSE REGULATOR receiver
G8758_08725	COG0482	sulfurtransferase activity
G8758_08740	COG0484	heat shock protein binding
G8758_08745	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G8758_08755	COG3265	gluconokinase activity
G8758_08765	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G8758_08770	COG2086	electron transfer activity
G8758_08775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8758_08785	COG1842	Phage shock protein A
G8758_08805	COG1615	UPF0182 protein
G8758_08810	COG3480	Lon protease (S16) C-terminal proteolytic domain
G8758_08835	COG2816	NAD+ diphosphatase activity
G8758_08865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8758_08870	COG0765	amino acid transport
G8758_08875	COG1126	abc transporter atp-binding protein
G8758_08880	COG1522	sequence-specific DNA binding
G8758_08885	COG1280	lysine exporter protein (LysE YggA)
G8758_08890	COG1472	Belongs to the glycosyl hydrolase 3 family
G8758_08895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G8758_08910	COG1028	Short-chain dehydrogenase reductase Sdr
G8758_08915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8758_08925	COG0113	porphobilinogen synthase activity
G8758_08935	COG0181	hydroxymethylbilane synthase activity
G8758_08940	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G8758_08945	COG3253	May function as heme-dependent peroxidase
G8758_08955	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G8758_08960	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G8758_08985	COG2022	thiamine diphosphate biosynthetic process
G8758_08995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8758_08995	COG2022	thiamine diphosphate biosynthetic process
G8758_09000	COG0352	thiamine-phosphate diphosphorylase activity
G8758_09020	COG0557	exoribonuclease II activity
G8758_09040	COG1309	transcriptional regulator
G8758_09050	COG2814	Major facilitator Superfamily
G8758_09055	COG0006	proline dipeptidase activity
G8758_09065	COG2239	Acts as a magnesium transporter
G8758_09080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G8758_09085	COG1595	DNA-templated transcription, initiation
G8758_09090	COG4122	O-methyltransferase activity
G8758_09110	COG1611	Belongs to the LOG family
G8758_09115	COG1126	abc transporter atp-binding protein
G8758_09120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8758_09125	COG0765	amino acid transport
G8758_09130	COG0765	amino acid transport
G8758_09135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8758_09140	COG2171	N-acyltransferase activity
G8758_09155	COG3226	Transcriptional regulator
G8758_09160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G8758_09195	COG1217	gtp-binding protein TYPA
G8758_09210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G8758_09215	COG0601	transmembrane transport
G8758_09260	COG0477	Major facilitator Superfamily
G8758_09265	COG0473	3-isopropylmalate dehydrogenase activity
G8758_09265	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G8758_09275	COG1012	belongs to the aldehyde dehydrogenase family
G8758_09285	COG3971	2-oxopent-4-enoate hydratase activity
G8758_09310	COG0300	oxidoreductase activity
G8758_09350	COG1309	transcriptional regulator
G8758_09370	COG0012	GTP binding
G8758_09375	COG1322	Protein conserved in bacteria
G8758_09385	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G8758_09390	COG2409	Drug exporters of the RND superfamily
G8758_09405	COG1570	exodeoxyribonuclease VII activity
G8758_09410	COG1722	exodeoxyribonuclease VII activity
G8758_09415	COG2326	polyphosphate kinase activity
G8758_09450	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
G8758_09455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G8758_09470	COG2971	BadF BadG BcrA BcrD
G8758_09475	COG2070	2-Nitropropane dioxygenase
G8758_09490	COG1522	sequence-specific DNA binding
G8758_09495	COG0598	Magnesium transport protein CorA
G8758_09520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G8758_09525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G8758_09545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G8758_09545	COG0519	Catalyzes the synthesis of GMP from XMP
G8758_09560	COG1132	(ABC) transporter
G8758_09565	COG1132	(ABC) transporter
G8758_09575	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G8758_09590	COG0516	GMP reductase activity
G8758_09625	COG1846	Transcriptional regulator
G8758_09630	COG1120	ATPase activity
G8758_09635	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8758_09640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8758_09655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G8758_09655	COG2755	lipolytic protein G-D-S-L family
G8758_09660	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G8758_09660	COG2755	lipolytic protein G-D-S-L family
G8758_09665	COG0459	protein refolding
G8758_09670	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G8758_09690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G8758_09695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G8758_09705	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G8758_09715	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G8758_09720	COG0456	acetyltransferase
G8758_09730	COG0802	atpase or kinase
G8758_09735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G8758_09740	COG0438	transferase activity, transferring glycosyl groups
G8758_09745	COG0546	phosphoglycolate phosphatase activity
G8758_09760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G8758_09770	COG1802	Transcriptional regulator
G8758_09775	COG2271	Major facilitator Superfamily
G8758_09780	COG1260	myo-inositol-1-phosphate synthase
G8758_09785	COG0667	Aldo Keto reductase
G8758_09805	COG0736	holo-[acyl-carrier-protein] synthase activity
G8758_09810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G8758_09815	COG1072	(Pantothenic acid kinase))
G8758_09825	COG1970	mechanosensitive ion channel activity
G8758_09830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8758_09835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G8758_09840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G8758_09855	COG0101	tRNA pseudouridine synthase activity
G8758_09860	COG0203	ribosomal protein L17
G8758_09865	COG0202	RNA polymerase activity
G8758_09870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G8758_09875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G8758_09880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G8758_09885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G8758_09890	COG3191	aminopeptidase activity
G8758_09895	COG1175	transmembrane transport
G8758_09910	COG0402	S-adenosylhomocysteine deaminase activity
G8758_09915	COG0024	Methionine aminopeptidase
G8758_09920	COG0563	adenylate kinase activity
G8758_09930	COG0200	Binds to the 23S rRNA
G8758_09935	COG1841	ribosomal large subunit assembly
G8758_09940	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G8758_09950	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G8758_09955	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G8758_09960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G8758_09965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G8758_09970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G8758_09975	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G8758_09980	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G8758_09985	COG0255	Belongs to the universal ribosomal protein uL29 family
G8758_09990	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G8758_09995	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G8758_10000	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G8758_10005	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G8758_10010	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G8758_10015	COG0089	rRNA binding
G8758_10020	COG0088	Forms part of the polypeptide exit tunnel
G8758_10025	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G8758_10030	COG0051	transcription antitermination factor activity, RNA binding
G8758_10035	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G8758_10040	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G8758_10045	COG0049	tRNA binding
G8758_10050	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G8758_10055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G8758_10060	COG0085	RNA polymerase activity
G8758_10065	COG0442	prolyl-tRNA aminoacylation
G8758_10070	COG0183	Belongs to the thiolase family
G8758_10075	COG0737	Belongs to the 5'-nucleotidase family
G8758_10080	COG0222	ribosome binding
G8758_10085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G8758_10100	COG0081	regulation of translation
G8758_10105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G8758_10125	COG0436	Aminotransferase
G8758_10140	COG0739	heme binding
G8758_10145	COG1136	(ABC) transporter
G8758_10155	COG2197	response regulator
G8758_10195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G8758_10200	COG3485	protocatechuate 3,4-dioxygenase
G8758_10210	COG0745	RESPONSE REGULATOR receiver
G8758_10215	COG0456	acetyltransferase
G8758_10220	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G8758_10245	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G8758_10280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G8758_10305	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G8758_10315	COG2030	dehydratase
G8758_10330	COG4989	oxidoreductase activity
G8758_10355	COG0601	transmembrane transport
G8758_10425	COG0754	glutathionylspermidine amidase activity
G8758_10440	COG1609	Transcriptional regulator
G8758_10455	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G8758_10470	COG0726	polysaccharide deacetylase
G8758_10480	COG1396	sequence-specific DNA binding
G8758_10485	COG0740	serine-type endopeptidase activity
G8758_10490	COG0740	serine-type endopeptidase activity
G8758_10540	COG0587	DNA-directed DNA polymerase activity
G8758_10580	COG0318	PFAM AMP-dependent synthetase and ligase
G8758_10590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G8758_10600	COG1309	transcriptional regulator
G8758_10605	COG1131	(ABC) transporter
G8758_10620	COG2890	protein-(glutamine-N5) methyltransferase activity
G8758_10640	COG1666	GTP binding
G8758_10655	COG2837	iron assimilation
G8758_10660	COG0501	Belongs to the peptidase M48B family
G8758_10695	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G8758_10700	COG2755	lipolytic protein G-D-S-L family
G8758_10700	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G8758_10715	COG0531	amino acid
G8758_10750	COG2186	Transcriptional regulator
G8758_10760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G8758_10760	COG1648	precorrin-2 dehydrogenase activity
G8758_10770	COG3123	guanosine phosphorylase activity
G8758_10780	COG0583	DNA-binding transcription factor activity
G8758_10790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8758_10820	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8758_10830	COG2860	membrane
G8758_10845	COG0142	geranyltranstransferase activity
G8758_10850	COG0644	oxidoreductase
G8758_10855	COG2226	methyltransferase
G8758_10860	COG1169	isochorismate synthase
G8758_10870	COG0765	amino acid transport
G8758_10875	COG1126	abc transporter atp-binding protein
G8758_10885	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
G8758_10895	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G8758_10905	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
G8758_10940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G8758_10960	COG3668	Plasmid stabilization system
G8758_10965	COG0438	transferase activity, transferring glycosyl groups
G8758_11000	COG1396	sequence-specific DNA binding
G8758_11005	COG3135	benzoate transporter
G8758_11020	COG4948	Mandelate Racemase Muconate Lactonizing
G8758_11025	COG1609	Transcriptional regulator
G8758_11035	COG0395	ABC-type sugar transport system, permease component
G8758_11040	COG1175	transmembrane transport
G8758_11060	COG0154	amidase activity
G8758_11110	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G8758_11135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G8758_11140	COG1333	cytochrome c biogenesis protein
G8758_11145	COG0785	Cytochrome C biogenesis protein
G8758_11155	COG0406	alpha-ribazole phosphatase activity
G8758_11180	COG2188	Transcriptional regulator
G8758_11185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G8758_11190	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
G8758_11215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G8758_11220	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G8758_11230	COG4208	sulfate ABC transporter
G8758_11235	COG3842	ATPase activity
G8758_11240	COG0640	Transcriptional regulator
G8758_11245	COG0123	including yeast histone deacetylase and acetoin utilization protein
G8758_11250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G8758_11255	COG0569	domain protein
G8758_11260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G8758_11275	COG2217	Heavy metal translocating P-type atpase
G8758_11285	COG1082	Xylose isomerase domain protein TIM barrel
G8758_11290	COG0248	Ppx GppA phosphatase
G8758_11295	COG1754	DNA topoisomerase type I activity
G8758_11295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G8758_11305	COG2890	protein-(glutamine-N5) methyltransferase activity
G8758_11330	COG1054	Belongs to the UPF0176 family
G8758_11340	COG1205	dead DEAH box helicase
G8758_11340	COG1111	helicase
G8758_11400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G8758_11405	COG1136	(ABC) transporter
G8758_11405	COG0577	efflux transmembrane transporter activity
G8758_11420	COG1609	Transcriptional regulator
G8758_11435	COG1175	transmembrane transport
G8758_11440	COG0395	ABC-type sugar transport system, permease component
G8758_11445	COG1349	DNA-binding transcription factor activity
G8758_11450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G8758_11485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8758_11490	COG1408	metallophosphoesterase
G8758_11495	COG1132	(ABC) transporter
G8758_11500	COG1132	(ABC) transporter
G8758_11510	COG0076	glutamate decarboxylase activity
G8758_11525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G8758_11530	COG0151	Belongs to the GarS family
G8758_11550	COG2814	Major facilitator Superfamily
G8758_11560	COG2271	Major facilitator Superfamily
G8758_11565	COG1301	dicarboxylic acid transport
G8758_11570	COG1028	Short-chain dehydrogenase reductase Sdr
G8758_11580	COG1953	Uracil, thiamine, allantoin
G8758_11585	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G8758_11595	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G8758_11610	COG2252	PERMEase
G8758_11615	COG0590	tRNA wobble adenosine to inosine editing
G8758_11635	COG2233	PERMEase
G8758_11645	COG1414	Transcriptional regulator
G8758_11655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G8758_11665	COG3257	ureidoglycine aminohydrolase activity
G8758_11705	COG1063	alcohol dehydrogenase
G8758_11715	COG3833	ABC-type maltose transport systems, permease component
G8758_11720	COG0395	ABC-type sugar transport system, permease component
G8758_11725	COG1175	transmembrane transport
G8758_11755	COG0395	ABC-type sugar transport system, permease component
G8758_11760	COG1175	transmembrane transport
G8758_11775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8758_11785	COG0406	alpha-ribazole phosphatase activity
G8758_11800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G8758_11820	COG0454	-acetyltransferase
G8758_11885	COG0405	Gamma-glutamyltransferase
G8758_11905	COG3622	Belongs to the hyi family
G8758_11910	COG2084	Dehydrogenase
G8758_11915	COG3960	tartronate-semialdehyde synthase activity
G8758_11920	COG1929	Belongs to the glycerate kinase type-1 family
G8758_11925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G8758_11930	COG0745	RESPONSE REGULATOR receiver
G8758_11945	COG1012	belongs to the aldehyde dehydrogenase family
G8758_11955	COG1177	transmembrane transport
G8758_11960	COG1176	ABC-type spermidine putrescine transport system, permease component I
G8758_11965	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G8758_11970	COG3842	ATPase activity
G8758_12005	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G8758_12010	COG0477	Major facilitator Superfamily
G8758_12015	COG1414	Transcriptional regulator
G8758_12020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G8758_12025	COG3185	4-Hydroxyphenylpyruvate dioxygenase
G8758_12025	COG1082	Xylose isomerase domain protein TIM barrel
G8758_12045	COG3485	protocatechuate 3,4-dioxygenase
G8758_12050	COG3485	protocatechuate 3,4-dioxygenase
G8758_12065	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G8758_12070	COG0183	Belongs to the thiolase family
G8758_12080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G8758_12085	COG1414	Transcriptional regulator
G8758_12115	COG2205	protein histidine kinase activity
G8758_12120	COG0745	RESPONSE REGULATOR receiver
G8758_12130	COG3304	Inner membrane component domain
G8758_12135	COG0531	amino acid
G8758_12140	COG0135	phosphoribosylanthranilate isomerase activity
G8758_12155	COG0513	Belongs to the DEAD box helicase family
G8758_12175	COG0789	Transcriptional regulator
G8758_12190	COG2807	transmembrane transport
G8758_12200	COG1028	Short-chain dehydrogenase reductase Sdr
G8758_12215	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G8758_12220	COG2818	Glycosylase
G8758_12230	COG1597	lipid kinase activity
G8758_12240	COG2261	transglycosylase associated protein
G8758_12270	COG1595	DNA-templated transcription, initiation
G8758_12280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G8758_12305	COG1595	DNA-templated transcription, initiation
G8758_12320	COG2723	6-phospho-beta-galactosidase activity
G8758_12325	COG0395	ABC-type sugar transport system, permease component
G8758_12345	COG2273	Hydrolase Family 16
G8758_12360	COG3850	Histidine kinase
G8758_12365	COG0577	efflux transmembrane transporter activity
G8758_12365	COG1136	(ABC) transporter
G8758_12370	COG0577	efflux transmembrane transporter activity
G8758_12370	COG1136	(ABC) transporter
G8758_12375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G8758_12380	COG0280	phosphate acetyltransferase
G8758_12380	COG0857	belongs to the CobB CobQ family
G8758_12400	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G8758_12410	COG0702	epimerase
G8758_12415	COG1064	alcohol dehydrogenase
G8758_12420	COG0583	DNA-binding transcription factor activity
G8758_12425	COG0789	Transcriptional regulator
G8758_12430	COG0484	heat shock protein binding
G8758_12435	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G8758_12440	COG0443	Heat shock 70 kDa protein
G8758_12465	COG2259	Doxx family
G8758_12470	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G8758_12525	COG1121	(ABC) transporter
G8758_12535	COG2226	methyltransferase
G8758_12550	COG1280	lysine exporter protein (LysE YggA)
G8758_12555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G8758_12565	COG0129	dihydroxy-acid dehydratase activity
G8758_12575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8758_12600	COG1120	ATPase activity
G8758_12610	COG0604	alcohol dehydrogenase
G8758_12615	COG1132	(ABC) transporter
G8758_12620	COG1132	(ABC) transporter
G8758_12655	COG1505	serine-type exopeptidase activity
G8758_12690	COG1305	Transglutaminase-like
G8758_12720	COG1116	anion transmembrane transporter activity
G8758_12725	COG3290	protein histidine kinase activity
G8758_12730	COG4565	transcriptional regulatory protein
G8758_12735	COG0789	Transcriptional regulator
G8758_12740	COG0667	Aldo Keto reductase
G8758_12760	COG0739	heme binding
G8758_12765	COG0477	Major facilitator Superfamily
G8758_12775	COG1349	DNA-binding transcription factor activity
G8758_12780	COG1070	Carbohydrate kinase
G8758_12785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8758_12790	COG1063	alcohol dehydrogenase
G8758_12795	COG0395	ABC-type sugar transport system, permease component
G8758_12810	COG1349	DNA-binding transcription factor activity
G8758_12820	COG1349	DNA-binding transcription factor activity
G8758_12830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G8758_12835	COG0191	fructose-bisphosphate aldolase activity
G8758_12840	COG1070	Carbohydrate kinase
G8758_12850	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
G8758_12860	COG1072	(Pantothenic acid kinase))
G8758_12875	COG0037	tRNA processing
G8758_12875	COG0590	tRNA wobble adenosine to inosine editing
G8758_12895	COG1643	Atp-dependent helicase
G8758_12905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G8758_12920	COG1122	ATPase activity
G8758_12925	COG4721	ABC-type cobalt transport system, permease component
G8758_12930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G8758_12930	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G8758_12955	COG1309	transcriptional regulator
G8758_12960	COG1320	monovalent cation:proton antiporter activity
G8758_12965	COG2212	antiporter activity
G8758_12975	COG0651	ATP synthesis coupled electron transport
G8758_12985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G8758_12985	COG2111	Na H antiporter
G8758_13005	COG0475	glutathione-regulated potassium exporter activity
G8758_13030	COG1595	DNA-templated transcription, initiation
G8758_13035	COG1028	Short-chain dehydrogenase reductase Sdr
G8758_13050	COG0717	Belongs to the dCTP deaminase family
G8758_13065	COG1876	peptidase activity
G8758_13075	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G8758_13080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G8758_13085	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G8758_13095	COG1846	Transcriptional regulator
G8758_13125	COG1120	ATPase activity
G8758_13130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8758_13135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8758_13155	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G8758_13205	COG2814	Major facilitator Superfamily
G8758_13225	COG0179	Fumarylacetoacetate (FAA) hydrolase
G8758_13245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G8758_13250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G8758_13260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G8758_13300	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G8758_13325	COG1174	glycine betaine transport
G8758_13330	COG0517	IMP dehydrogenase activity
G8758_13330	COG1125	glycine betaine transport
G8758_13345	COG2211	Major facilitator Superfamily
G8758_13355	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G8758_13360	COG2814	Major facilitator Superfamily
G8758_13370	COG1113	amino acid transport
G8758_13375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G8758_13400	COG0686	Belongs to the AlaDH PNT family
G8758_13410	COG0673	inositol 2-dehydrogenase activity
G8758_13450	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8758_13455	COG0022	dehydrogenase e1 component
G8758_13465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G8758_13470	COG1950	PFAM Membrane protein of
G8758_13485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G8758_13505	COG4447	cellulose binding
G8758_13510	COG1937	Protein conserved in bacteria
G8758_13515	COG2217	Heavy metal translocating P-type atpase
G8758_13520	COG0697	spore germination
G8758_13550	COG0305	Participates in initiation and elongation during chromosome replication
G8758_13570	COG0359	binds to the 23S rRNA
G8758_13575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G8758_13585	COG0360	Binds together with S18 to 16S ribosomal RNA
G8758_13605	COG1362	aminopeptidase activity
G8758_13610	COG2197	response regulator
G8758_13615	COG4585	Histidine kinase
G8758_13630	COG0738	Major facilitator superfamily
G8758_13645	COG0406	alpha-ribazole phosphatase activity
G8758_13650	COG0617	tRNA 3'-terminal CCA addition
G8758_13670	COG0492	ferredoxin-NADP+ reductase activity
G8758_13675	COG3118	belongs to the thioredoxin family
G8758_13690	COG1192	Involved in chromosome partitioning
G8758_13695	COG0357	Ribosomal RNA small subunit methyltransferase G
G8758_13705	COG0706	membrane insertase activity
G8758_13710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G8758_13715	COG0594	ribonuclease P activity
G8758_13720	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G8758_13725	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G8758_13730	COG0592	DNA-directed DNA polymerase activity
G8758_13735	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G8758_13740	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G8758_13745	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
G8758_13750	COG0187	DNA topoisomerase II activity
G8758_13755	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G8758_13780	COG1215	transferase activity, transferring glycosyl groups
G8758_13810	COG3764	Sortase (surface protein transpeptidase)
G8758_13830	COG0515	serine threonine protein kinase
G8758_13835	COG0768	penicillin binding
G8758_13850	COG1716	ATPase activity
G8758_13855	COG1716	ATPase activity
G8758_13865	COG3226	Transcriptional regulator
G8758_13895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G8758_13910	COG0833	amino acid
G8758_13915	COG0385	Bile acid
G8758_13945	COG1228	amidohydrolase
G8758_13970	COG0561	phosphatase activity
G8758_13975	COG0584	glycerophosphoryl diester phosphodiesterase
G8758_14015	COG1609	Transcriptional regulator
G8758_14025	COG1175	transmembrane transport
G8758_14060	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G8758_14065	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G8758_14085	COG2233	PERMEase
G8758_14090	COG0778	Nitroreductase
G8758_14130	COG2368	4-hydroxyphenylacetate
G8758_14160	COG3104	oligopeptide transport
G8758_14165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G8758_14170	COG0425	Belongs to the sulfur carrier protein TusA family
G8758_14170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G8758_14175	COG0077	Prephenate dehydratase
G8758_14195	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G8758_14210	COG0561	phosphatase activity
G8758_14235	COG0037	tRNA processing
G8758_14245	COG1621	beta-fructofuranosidase activity
G8758_14250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G8758_14255	COG0302	gtp cyclohydrolase
G8758_14265	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G8758_14270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G8758_14285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G8758_14290	COG2814	Major facilitator Superfamily
G8758_14305	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G8758_14330	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G8758_14335	COG2376	Dihydroxyacetone kinase
G8758_14340	COG1461	Dihydroxyacetone kinase
G8758_14350	COG1194	a g-specific adenine glycosylase
G8758_14360	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
G8758_14370	COG0640	Transcriptional regulator
G8758_14405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G8758_14415	COG2271	Major facilitator Superfamily
G8758_14420	COG0531	amino acid
G8758_14440	COG3290	protein histidine kinase activity
G8758_14445	COG4565	transcriptional regulatory protein
G8758_14495	COG2186	Transcriptional regulator
G8758_14510	COG1435	thymidine kinase activity
G8758_14540	COG1473	amidohydrolase
G8758_14570	COG0587	DNA-directed DNA polymerase activity
G8758_14590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G8758_14625	COG0776	regulation of translation
G8758_14630	COG2226	methyltransferase
G8758_14665	COG3336	cytochrome c oxidase
G8758_14680	COG0433	COG0433 Predicted ATPase
G8758_14685	COG2318	DinB family
G8758_14705	COG0765	amino acid transport
G8758_14710	COG1126	abc transporter atp-binding protein
G8758_14715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8758_14720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8758_14730	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8758_14780	COG2318	DinB family
G8758_14785	COG1126	abc transporter atp-binding protein
G8758_14790	COG0765	amino acid transport
G8758_14795	COG0765	amino acid transport
G8758_14810	COG3938	Belongs to the proline racemase family
G8758_14870	COG1012	belongs to the aldehyde dehydrogenase family
G8758_14875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8758_14895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8758_14900	COG1254	Belongs to the acylphosphatase family
G8758_14905	COG0583	DNA-binding transcription factor activity
G8758_14910	COG0697	spore germination
G8758_14915	COG3291	Pkd domain containing protein
G8758_14915	COG3525	Glycosyl hydrolase, family 20, catalytic domain
G8758_14920	COG0679	Auxin Efflux Carrier
G8758_14935	COG4604	ABC transporter, ATP-binding protein
G8758_14955	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G8758_14965	COG0702	epimerase
G8758_14970	COG0415	Belongs to the DNA photolyase family
G8758_14990	COG0477	Major facilitator Superfamily
G8758_14995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8758_15015	COG0747	negative chemotaxis
G8758_15030	COG4172	Belongs to the ABC transporter superfamily
G8758_15035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8758_15080	COG1742	UPF0060 membrane protein
G8758_15090	COG1473	amidohydrolase
G8758_15095	COG0477	Major facilitator Superfamily
G8758_15105	COG0277	FAD linked oxidase domain protein
G8758_15120	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G8758_15120	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G8758_15120	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G8758_15125	COG1105	Belongs to the carbohydrate kinase PfkB family
G8758_15145	COG2733	membrane
G8758_15225	COG4122	O-methyltransferase activity
G8758_15240	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G8758_15285	COG0601	transmembrane transport
G8758_15340	COG1609	Transcriptional regulator
G8758_15350	COG0477	Major facilitator Superfamily
G8758_15355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G8758_15360	COG1957	nucleoside hydrolase
G8758_15365	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G8758_15375	COG1309	transcriptional regulator
G8758_15385	COG0475	glutathione-regulated potassium exporter activity
G8758_15385	COG0569	domain protein
G8758_15390	COG0010	Belongs to the arginase family
G8758_15405	COG2084	Dehydrogenase
G8758_15420	COG0477	Major facilitator Superfamily
G8758_15425	COG1028	Short-chain dehydrogenase reductase Sdr
G8758_15435	COG1063	alcohol dehydrogenase
G8758_15445	COG2252	PERMEase
G8758_15450	COG2372	response to copper ion
G8758_15505	COG0477	Major facilitator Superfamily
G8758_15530	COG3486	L-lysine 6-monooxygenase (NADPH) activity
G8758_15545	COG2072	flavoprotein involved in K transport
G8758_15550	COG1027	Aspartate ammonia-lyase
G8758_15570	COG0583	DNA-binding transcription factor activity
G8758_15590	COG1012	belongs to the aldehyde dehydrogenase family
G8758_15600	COG0300	oxidoreductase activity
G8758_15605	COG0477	Major facilitator Superfamily
G8758_15640	COG0366	Alpha amylase catalytic
G8758_15665	COG1609	Transcriptional regulator
G8758_15680	COG1902	pentaerythritol trinitrate reductase activity
G8758_15705	COG2197	response regulator
G8758_15710	COG4585	Histidine kinase
G8758_15730	COG1321	iron dependent repressor
G8758_15735	COG1609	Transcriptional regulator
G8758_15750	COG1024	Enoyl-CoA hydratase
G8758_15765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G8758_15775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G8758_15785	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
G8758_15800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8758_15800	COG0357	Ribosomal RNA small subunit methyltransferase G
G8758_15825	COG0318	PFAM AMP-dependent synthetase and ligase
G8758_15850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G8758_15855	COG1832	CoA-binding protein
G8758_15860	COG2315	Protein conserved in bacteria
G8758_15865	COG1653	transport
G8758_15870	COG1175	transmembrane transport
G8758_15875	COG0395	ABC-type sugar transport system, permease component
G8758_15885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G8758_15890	COG0047	phosphoribosylformylglycinamidine synthase activity
G8758_15895	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G8758_15900	COG3012	SEC-C Motif Domain Protein
G8758_15935	COG1846	Transcriptional regulator
G8758_15960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G8758_15990	COG1595	DNA-templated transcription, initiation
G8758_16005	COG1196	nuclear chromosome segregation
G8758_16005	COG0741	lytic transglycosylase activity
G8758_16005	COG0739	heme binding
G8758_16015	COG0386	Belongs to the glutathione peroxidase family
G8758_16035	COG1309	transcriptional regulator
G8758_16045	COG2807	transmembrane transport
G8758_16055	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G8758_16070	COG1113	amino acid transport
G8758_16095	COG0351	phosphomethylpyrimidine kinase
G8758_16155	COG0702	epimerase
G8758_16190	COG0477	Major facilitator Superfamily
G8758_16195	COG0343	queuine tRNA-ribosyltransferase activity
G8758_16220	COG2814	Major facilitator Superfamily
G8758_16230	COG0671	phosphoesterase, PA-phosphatase related
G8758_16280	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G8758_16300	COG0564	pseudouridine synthase activity
G8758_16355	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G8758_16360	COG1201	RNA secondary structure unwinding
G8758_16390	COG0531	amino acid
G8758_16420	COG2847	Copper chaperone PCu(A)C
G8758_16430	COG0228	four-way junction DNA binding
G8758_16475	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G8758_16480	COG2205	protein histidine kinase activity
G8758_16485	COG0745	RESPONSE REGULATOR receiver
G8758_16530	COG1511	domain protein
G8758_16535	COG1129	ABC transporter
G8758_16550	COG0583	DNA-binding transcription factor activity
G8758_16575	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
G8758_16585	COG0697	spore germination
G8758_16590	COG0028	Belongs to the TPP enzyme family
G8758_16610	COG1733	regulation of RNA biosynthetic process
G8758_16635	COG0514	ATP-dependent DNA helicase (RecQ)
G8758_16650	COG1505	serine-type exopeptidase activity
G8758_16680	COG0604	alcohol dehydrogenase
G8758_16685	COG1966	Carbon starvation protein
G8758_16705	COG0656	L-ascorbic acid biosynthetic process
G8758_16725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G8758_16730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G8758_16750	COG0588	phosphoglycerate mutase activity
G8758_16760	COG5002	protein histidine kinase activity
G8758_16790	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G8758_16795	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G8758_16805	COG0215	cysteine-tRNA ligase activity
G8758_16810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8758_16835	COG0366	Alpha amylase catalytic