locus-tag	class	description
APLC1_0041	COG0438	transferase activity, transferring glycosyl groups
APLC1_0044	COG0220	tRNA (guanine-N7-)-methyltransferase activity
APLC1_0050	COG1797	cobyrinic acid a,c-diamide synthase activity
APLC1_0059	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APLC1_0060	COG0237	dephospho-CoA kinase activity
APLC1_0060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APLC1_0061	COG0586	Pfam SNARE associated Golgi protein
APLC1_0063	COG1366	Belongs to the anti-sigma-factor antagonist family
APLC1_0067	COG1619	proteins homologs of microcin C7 resistance protein MccF
APLC1_0073	COG1489	DNA binding
APLC1_0074	COG1489	DNA binding
APLC1_0079	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
APLC1_0083	COG0037	tRNA processing
APLC1_0084	COG0463	Glycosyl transferase, family 2
APLC1_0087	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APLC1_0089	COG0745	RESPONSE REGULATOR receiver
APLC1_0090	COG3411	Ferredoxin
APLC1_0091	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
APLC1_0092	COG0459	protein refolding
APLC1_0095	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
APLC1_0098	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
APLC1_0099	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
APLC1_0102	COG0242	peptide deformylase activity
APLC1_0106	COG0675	Transposase, IS605 OrfB family
APLC1_0108	COG1836	PFAM Integral membrane protein DUF92
APLC1_0117	COG0357	Ribosomal RNA small subunit methyltransferase G
APLC1_0119	COG0616	signal peptide processing
APLC1_0120	COG0697	spore germination
APLC1_0123	COG2003	Belongs to the UPF0758 family
APLC1_0131	COG1741	Belongs to the pirin family
APLC1_0132	COG1007	ATP synthesis coupled electron transport
APLC1_0133	COG1007	ATP synthesis coupled electron transport
APLC1_0134	COG0500	methyltransferase
APLC1_0135	COG2226	methyltransferase
APLC1_0136	COG1280	lysine exporter protein (LysE YggA)
APLC1_0137	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
APLC1_0138	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
APLC1_0141	COG0826	peptidase U32
APLC1_0143	COG4221	oxidoreductase activity
APLC1_0144	COG0156	8-amino-7-oxononanoate synthase activity
APLC1_0146	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APLC1_0148	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APLC1_0150	COG0484	heat shock protein binding
APLC1_0154	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APLC1_0162	COG0529	Catalyzes the synthesis of activated sulfate
APLC1_0165	COG0297	glycogen (starch) synthase activity
APLC1_0168	COG3429	Glucose-6-phosphate dehydrogenase subunit
APLC1_0168	COG3409	Peptidoglycan-binding domain 1 protein
APLC1_0169	COG3409	Peptidoglycan-binding domain 1 protein
APLC1_0169	COG3429	Glucose-6-phosphate dehydrogenase subunit
APLC1_0170	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APLC1_0171	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
APLC1_0172	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
APLC1_0173	COG0675	Transposase, IS605 OrfB family
APLC1_0177	COG1271	oxidase subunit
APLC1_0182	COG0300	oxidoreductase activity
APLC1_0182	COG3000	fatty acid hydroxylase
APLC1_0185	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APLC1_0186	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
APLC1_0188	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APLC1_0195	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
APLC1_0196	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APLC1_0203	COG4251	negative regulation of phosphorylation
APLC1_0204	COG0784	Response regulator, receiver
APLC1_0204	COG2205	protein histidine kinase activity
APLC1_0211	COG0668	transmembrane transport
APLC1_0214	COG2912	Transglutaminase-like superfamily
APLC1_0215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
APLC1_0217	COG1872	DUF167
APLC1_0219	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APLC1_0220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
APLC1_0221	COG1268	BioY protein
APLC1_0222	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
APLC1_0225	COG0581	inorganic phosphate transmembrane transporter activity
APLC1_0226	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APLC1_0228	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
APLC1_0239	COG1487	ribonuclease activity
APLC1_0251	COG2361	Protein of unknown function DUF86
APLC1_0258	COG0784	Response regulator, receiver
APLC1_0258	COG2198	Histidine kinase
APLC1_0258	COG5002	protein histidine kinase activity
APLC1_0259	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APLC1_0261	COG1376	ErfK ybiS ycfS ynhG family protein
APLC1_0263	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
APLC1_0264	COG1472	Belongs to the glycosyl hydrolase 3 family
APLC1_0266	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
APLC1_0271	COG2911	Protein conserved in bacteria
APLC1_0271	COG3266	domain, Protein
APLC1_0271	COG1361	Conserved repeat domain
APLC1_0272	COG0793	Belongs to the peptidase S41A family
APLC1_0274	COG0745	RESPONSE REGULATOR receiver
APLC1_0275	COG0730	response to heat
APLC1_0278	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APLC1_0278	COG3264	Mechanosensitive ion channel
APLC1_0280	COG1943	Transposase
APLC1_0284	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APLC1_0285	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APLC1_0286	COG0017	Asparaginyl-tRNA synthetase
APLC1_0296	COG0515	serine threonine protein kinase
APLC1_0296	COG2815	serine threonine protein kinase
APLC1_0307	COG0105	UTP biosynthetic process
APLC1_0308	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APLC1_0315	COG0784	Response regulator, receiver
APLC1_0315	COG3437	response regulator, receiver
APLC1_0316	COG3852	Histidine kinase
APLC1_0321	COG0297	glycogen (starch) synthase activity
APLC1_0322	COG0297	glycogen (starch) synthase activity
APLC1_0325	COG2198	Histidine kinase
APLC1_0325	COG2205	protein histidine kinase activity
APLC1_0325	COG0784	Response regulator, receiver
APLC1_0326	COG0702	epimerase
APLC1_0327	COG0330	HflC and HflK could
APLC1_0333	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APLC1_0334	COG1032	radical SAM domain protein
APLC1_0335	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
APLC1_0336	COG1381	Involved in DNA repair and RecF pathway recombination
APLC1_0337	COG1381	Involved in DNA repair and RecF pathway recombination
APLC1_0339	COG0270	DNA (cytosine-5-)-methyltransferase activity
APLC1_0344	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
APLC1_0345	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APLC1_0345	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APLC1_0346	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APLC1_0346	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APLC1_0347	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APLC1_0347	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
APLC1_0348	COG3063	Type IV pilus biogenesis stability protein PilW
APLC1_0350	COG0222	ribosome binding
APLC1_0351	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
APLC1_0353	COG0081	regulation of translation
APLC1_0354	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
APLC1_0355	COG0250	Participates in transcription elongation, termination and antitermination
APLC1_0356	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
APLC1_0358	COG0335	large ribosomal subunit rRNA binding
APLC1_0359	COG0752	glycyl-tRNA synthetase alpha subunit
APLC1_0365	COG2205	protein histidine kinase activity
APLC1_0366	COG0494	nUDIX hydrolase
APLC1_0367	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APLC1_0369	COG0601	transmembrane transport
APLC1_0370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APLC1_0374	COG3586	endonuclease activity
APLC1_0375	COG0860	N-Acetylmuramoyl-L-alanine amidase
APLC1_0375	COG1388	LysM domain
APLC1_0398	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
APLC1_0399	COG3932	Exopolysaccharide synthesis, ExoD
APLC1_0403	COG0284	orotidine-5'-phosphate decarboxylase activity
APLC1_0403	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APLC1_0405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
APLC1_0406	COG1882	Formate acetyltransferase
APLC1_0407	COG0537	adenosine 5'-monophosphoramidase activity
APLC1_0411	COG1695	Transcriptional regulator
APLC1_0413	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APLC1_0415	COG2119	membrane
APLC1_0416	COG1640	4-alpha-glucanotransferase
APLC1_0417	COG1426	Protein conserved in bacteria
APLC1_0418	COG1187	pseudouridine synthase activity
APLC1_0420	COG0575	Belongs to the CDS family
APLC1_0422	COG1982	Orn Lys Arg decarboxylase major
APLC1_0423	COG0012	GTP binding
APLC1_0427	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APLC1_0429	COG0306	phosphate transporter
APLC1_0445	COG0464	growth
APLC1_0466	COG2886	Uncharacterised protein family (UPF0175)
APLC1_0473	COG2886	Uncharacterised protein family (UPF0175)
APLC1_0481	COG1598	PFAM Uncharacterised protein family UPF0150
APLC1_0482	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APLC1_0496	COG2327	Polysaccharide pyruvyl transferase
APLC1_0504	COG2027	D-alanyl-D-alanine carboxypeptidase
APLC1_0505	COG2045	Belongs to the ComB family
APLC1_0506	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
APLC1_0508	COG0768	penicillin binding
APLC1_0510	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
APLC1_0516	COG0754	glutathionylspermidine amidase activity
APLC1_0524	COG0598	Magnesium transport protein CorA
APLC1_0525	COG0515	serine threonine protein kinase
APLC1_0525	COG3266	domain, Protein
APLC1_0527	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
APLC1_0528	COG0840	transmembrane signaling receptor activity
APLC1_0530	COG1543	Belongs to the glycosyl hydrolase 57 family
APLC1_0531	COG1543	Belongs to the glycosyl hydrolase 57 family
APLC1_0538	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
APLC1_0551	COG0745	RESPONSE REGULATOR receiver
APLC1_0555	COG0515	serine threonine protein kinase
APLC1_0555	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_0558	COG1181	Belongs to the D-alanine--D-alanine ligase family
APLC1_0560	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
APLC1_0573	COG2886	Uncharacterised protein family (UPF0175)
APLC1_0580	COG4680	protein conserved in bacteria
APLC1_0584	COG2886	Uncharacterised protein family (UPF0175)
APLC1_0602	COG1111	helicase
APLC1_0602	COG1205	dead DEAH box helicase
APLC1_0608	COG0517	IMP dehydrogenase activity
APLC1_0609	COG5002	protein histidine kinase activity
APLC1_0610	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
APLC1_0610	COG0662	Cupin 2, conserved barrel domain protein
APLC1_0611	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
APLC1_0613	COG3937	granule-associated protein
APLC1_0614	COG0489	protein tyrosine kinase activity
APLC1_0616	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
APLC1_0618	COG1404	Belongs to the peptidase S8 family
APLC1_0618	COG4935	Belongs to the peptidase S8 family
APLC1_0619	COG1404	Belongs to the peptidase S8 family
APLC1_0619	COG4935	Belongs to the peptidase S8 family
APLC1_0621	COG0271	Belongs to the BolA IbaG family
APLC1_0622	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
APLC1_0625	COG0745	RESPONSE REGULATOR receiver
APLC1_0626	COG1012	belongs to the aldehyde dehydrogenase family
APLC1_0634	COG0784	Response regulator, receiver
APLC1_0634	COG2198	Histidine kinase
APLC1_0634	COG0643	Histidine kinase
APLC1_0635	COG5002	protein histidine kinase activity
APLC1_0636	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
APLC1_0637	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
APLC1_0643	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APLC1_0644	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APLC1_0647	COG1295	ribonuclease BN
APLC1_0649	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APLC1_0652	COG0277	FAD linked oxidase domain protein
APLC1_0653	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APLC1_0661	COG3659	wide pore channel activity
APLC1_0662	COG3659	wide pore channel activity
APLC1_0663	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APLC1_0668	COG2046	Belongs to the sulfate adenylyltransferase family
APLC1_0671	COG0784	Response regulator, receiver
APLC1_0671	COG2205	protein histidine kinase activity
APLC1_0675	COG3300	MHYT domain
APLC1_0675	COG5001	Diguanylate cyclase
APLC1_0676	COG2203	Gaf domain
APLC1_0676	COG3706	GGDEF domain
APLC1_0676	COG4251	negative regulation of phosphorylation
APLC1_0676	COG5001	Diguanylate cyclase
APLC1_0677	COG5002	protein histidine kinase activity
APLC1_0683	COG0242	peptide deformylase activity
APLC1_0684	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APLC1_0685	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
APLC1_0690	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APLC1_0701	COG0592	DNA-directed DNA polymerase activity
APLC1_0702	COG0592	DNA-directed DNA polymerase activity
APLC1_0706	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APLC1_0707	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APLC1_0708	COG1385	rRNA (uridine-N3-)-methyltransferase activity
APLC1_0709	COG2084	Dehydrogenase
APLC1_0714	COG3335	DDE superfamily endonuclease
APLC1_0719	COG0316	Belongs to the HesB IscA family
APLC1_0722	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
APLC1_0723	COG1215	transferase activity, transferring glycosyl groups
APLC1_0724	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APLC1_0726	COG1136	(ABC) transporter
APLC1_0729	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
APLC1_0731	COG1104	cysteine desulfurase activity
APLC1_0734	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
APLC1_0736	COG5002	protein histidine kinase activity
APLC1_0737	COG0745	RESPONSE REGULATOR receiver
APLC1_0744	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APLC1_0748	COG2226	methyltransferase
APLC1_0749	COG2226	methyltransferase
APLC1_0753	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
APLC1_0765	COG0772	Belongs to the SEDS family
APLC1_0768	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
APLC1_0770	COG0793	Belongs to the peptidase S41A family
APLC1_0771	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
APLC1_0778	COG1446	asparaginase
APLC1_0779	COG0745	RESPONSE REGULATOR receiver
APLC1_0780	COG0643	Histidine kinase
APLC1_0780	COG2198	Histidine kinase
APLC1_0781	COG0835	chemotaxis
APLC1_0782	COG0840	transmembrane signaling receptor activity
APLC1_0784	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
APLC1_0785	COG2201	protein-glutamate methylesterase activity
APLC1_0787	COG0863	Belongs to the N(4) N(6)-methyltransferase family
APLC1_0791	COG1333	cytochrome c biogenesis protein
APLC1_0793	COG5002	protein histidine kinase activity
APLC1_0794	COG2208	phosphoserine phosphatase activity
APLC1_0794	COG2770	Histidine kinase
APLC1_0796	COG0768	penicillin binding
APLC1_0800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APLC1_0810	COG4447	cellulose binding
APLC1_0811	COG1773	rubredoxin
APLC1_0813	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APLC1_0814	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APLC1_0815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APLC1_0817	COG0612	Peptidase, M16
APLC1_0818	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APLC1_0819	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APLC1_0820	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APLC1_0821	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
APLC1_0822	COG0815	Transfers the fatty acyl group on membrane lipoproteins
APLC1_0824	COG4251	negative regulation of phosphorylation
APLC1_0827	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
APLC1_0828	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APLC1_0829	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APLC1_0830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
APLC1_0831	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
APLC1_0832	COG0356	it plays a direct role in the translocation of protons across the membrane
APLC1_0834	COG0442	prolyl-tRNA aminoacylation
APLC1_0835	COG1555	photosystem II stabilization
APLC1_0835	COG1596	polysaccharide export
APLC1_0838	COG1104	cysteine desulfurase activity
APLC1_0839	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APLC1_0840	COG0693	protein deglycase activity
APLC1_0841	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APLC1_0841	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
APLC1_0852	COG1598	PFAM Uncharacterised protein family UPF0150
APLC1_0857	COG4636	protein conserved in cyanobacteria
APLC1_0858	COG4636	protein conserved in cyanobacteria
APLC1_0861	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
APLC1_0886	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APLC1_0887	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APLC1_0888	COG0735	belongs to the Fur family
APLC1_0919	COG0860	N-Acetylmuramoyl-L-alanine amidase
APLC1_0919	COG3409	Peptidoglycan-binding domain 1 protein
APLC1_0923	COG0673	inositol 2-dehydrogenase activity
APLC1_0925	COG2385	sporulation resulting in formation of a cellular spore
APLC1_0931	COG0574	Belongs to the PEP-utilizing enzyme family
APLC1_0931	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APLC1_0934	COG2211	Major facilitator Superfamily
APLC1_0935	COG1940	carbohydrate kinase activity
APLC1_0939	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
APLC1_0947	COG0798	PFAM Bile acid sodium symporter
APLC1_0948	COG0431	NADPH-dependent FMN reductase
APLC1_0949	COG0431	NADPH-dependent FMN reductase
APLC1_0950	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APLC1_0954	COG1293	RNA-binding protein homologous to eukaryotic snRNP
APLC1_0958	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
APLC1_0959	COG5001	Diguanylate cyclase
APLC1_0959	COG4251	negative regulation of phosphorylation
APLC1_0959	COG3706	GGDEF domain
APLC1_0959	COG2203	Gaf domain
APLC1_0961	COG0675	Transposase, IS605 OrfB family
APLC1_0970	COG4251	negative regulation of phosphorylation
APLC1_0971	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
APLC1_0983	COG0211	Belongs to the bacterial ribosomal protein bL27 family
APLC1_0989	COG0261	This protein binds to 23S rRNA in the presence of protein L20
APLC1_1000	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APLC1_1001	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
APLC1_1005	COG0484	heat shock protein binding
APLC1_1017	COG4636	protein conserved in cyanobacteria
APLC1_1019	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
APLC1_1022	COG5635	Nacht domain
APLC1_1022	COG2319	Wd-40 repeat
APLC1_1023	COG1748	Saccharopine dehydrogenase
APLC1_1028	COG2226	methyltransferase
APLC1_1029	COG4399	Belongs to the UPF0754 family
APLC1_1030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APLC1_1031	COG1160	GTP binding
APLC1_1032	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
APLC1_1034	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
APLC1_1036	COG1799	cell septum assembly
APLC1_1037	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
APLC1_1038	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
APLC1_1043	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
APLC1_1046	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APLC1_1046	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APLC1_1048	COG0515	serine threonine protein kinase
APLC1_1054	COG0776	regulation of translation
APLC1_1055	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
APLC1_1057	COG0322	excinuclease ABC activity
APLC1_1058	COG2124	cytochrome p450
APLC1_1060	COG1819	glycosyl
APLC1_1064	COG0142	geranyltranstransferase activity
APLC1_1066	COG0579	oxidoreductase
APLC1_1067	COG0004	ammonium transporteR
APLC1_1068	COG0004	ammonium transporteR
APLC1_1072	COG0501	Belongs to the peptidase M48B family
APLC1_1073	COG1704	LemA family
APLC1_1076	COG3977	Valine--pyruvate aminotransferase
APLC1_1080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
APLC1_1087	COG2239	Acts as a magnesium transporter
APLC1_1088	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
APLC1_1090	COG2319	Wd-40 repeat
APLC1_1090	COG3903	Transcriptional regulator
APLC1_1095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APLC1_1098	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
APLC1_1099	COG3266	domain, Protein
APLC1_1099	COG0515	serine threonine protein kinase
APLC1_1100	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
APLC1_1102	COG1834	amidinotransferase
APLC1_1112	COG1166	arginine decarboxylase activity
APLC1_1113	COG1210	Utp--glucose-1-phosphate uridylyltransferase
APLC1_1114	COG1640	4-alpha-glucanotransferase
APLC1_1116	COG1640	4-alpha-glucanotransferase
APLC1_1122	COG0515	serine threonine protein kinase
APLC1_1122	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_1128	COG3437	response regulator, receiver
APLC1_1129	COG2197	response regulator
APLC1_1131	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
APLC1_1138	COG0519	Catalyzes the synthesis of GMP from XMP
APLC1_1138	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APLC1_1166	COG1104	cysteine desulfurase activity
APLC1_1169	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APLC1_1170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
APLC1_1171	COG0805	protein transport
APLC1_1175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APLC1_1178	COG0463	Glycosyl transferase, family 2
APLC1_1178	COG1216	Glycosyl transferase, family 2
APLC1_1180	COG0270	DNA (cytosine-5-)-methyltransferase activity
APLC1_1181	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
APLC1_1182	COG4251	negative regulation of phosphorylation
APLC1_1182	COG5001	Diguanylate cyclase
APLC1_1182	COG2203	Gaf domain
APLC1_1182	COG3706	GGDEF domain
APLC1_1183	COG1187	pseudouridine synthase activity
APLC1_1189	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
APLC1_1191	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APLC1_1192	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APLC1_1193	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
APLC1_1193	COG4451	ribulose bisphosphate carboxylase, small
APLC1_1194	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
APLC1_1195	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APLC1_1196	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APLC1_1197	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APLC1_1198	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APLC1_1199	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APLC1_1201	COG1132	(ABC) transporter
APLC1_1205	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
APLC1_1208	COG3842	ATPase activity
APLC1_1210	COG1176	ABC-type spermidine putrescine transport system, permease component I
APLC1_1211	COG1177	transmembrane transport
APLC1_1212	COG0196	riboflavin kinase activity
APLC1_1220	COG0714	Associated with various cellular activities
APLC1_1222	COG1959	2 iron, 2 sulfur cluster binding
APLC1_1223	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
APLC1_1224	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
APLC1_1225	COG1304	FMN binding
APLC1_1228	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
APLC1_1229	COG0227	Belongs to the bacterial ribosomal protein bL28 family
APLC1_1235	COG1754	DNA topoisomerase type I activity
APLC1_1235	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
APLC1_1237	COG0612	Peptidase, M16
APLC1_1241	COG0390	transport system, permease component
APLC1_1248	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
APLC1_1249	COG0187	DNA topoisomerase II activity
APLC1_1249	COG1372	Participates in initiation and elongation during chromosome replication
APLC1_1253	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APLC1_1254	COG0740	serine-type endopeptidase activity
APLC1_1255	COG0544	peptidyl-prolyl cis-trans isomerase activity
APLC1_1256	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
APLC1_1257	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
APLC1_1258	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
APLC1_1259	COG3829	transcription factor binding
APLC1_1259	COG3290	protein histidine kinase activity
APLC1_1261	COG4948	Mandelate Racemase Muconate Lactonizing
APLC1_1264	COG0596	Alpha beta hydrolase
APLC1_1266	COG5001	Diguanylate cyclase
APLC1_1266	COG3300	MHYT domain
APLC1_1285	COG2239	Acts as a magnesium transporter
APLC1_1286	COG2239	Acts as a magnesium transporter
APLC1_1295	COG1185	polyribonucleotide nucleotidyltransferase activity
APLC1_1297	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APLC1_1298	COG0183	Belongs to the thiolase family
APLC1_1299	COG1028	Short-chain dehydrogenase reductase Sdr
APLC1_1302	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
APLC1_1304	COG2022	thiamine diphosphate biosynthetic process
APLC1_1304	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APLC1_1314	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
APLC1_1315	COG1122	ATPase activity
APLC1_1316	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APLC1_1318	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_1318	COG0515	serine threonine protein kinase
APLC1_1319	COG1064	alcohol dehydrogenase
APLC1_1320	COG1454	alcohol dehydrogenase
APLC1_1320	COG1012	belongs to the aldehyde dehydrogenase family
APLC1_1321	COG1012	belongs to the aldehyde dehydrogenase family
APLC1_1321	COG1454	alcohol dehydrogenase
APLC1_1325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APLC1_1329	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APLC1_1330	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APLC1_1332	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_1333	COG1950	PFAM Membrane protein of
APLC1_1335	COG0646	methionine synthase
APLC1_1335	COG1410	methionine synthase
APLC1_1336	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APLC1_1337	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
APLC1_1338	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
APLC1_1339	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
APLC1_1340	COG3906	Belongs to the UPF0473 family
APLC1_1341	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
APLC1_1355	COG0583	DNA-binding transcription factor activity
APLC1_1356	COG1850	ribulose-bisphosphate carboxylase activity
APLC1_1358	COG4451	ribulose bisphosphate carboxylase, small
APLC1_1363	COG0006	proline dipeptidase activity
APLC1_1364	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APLC1_1368	COG2091	lysine biosynthetic process via aminoadipic acid
APLC1_1374	COG1714	RDD family
APLC1_1380	COG0515	serine threonine protein kinase
APLC1_1380	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_1389	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
APLC1_1390	COG2264	protein methyltransferase activity
APLC1_1393	COG1252	NADH dehydrogenase
APLC1_1406	COG2361	Protein of unknown function DUF86
APLC1_1418	COG1192	Involved in chromosome partitioning
APLC1_1430	COG5001	Diguanylate cyclase
APLC1_1430	COG5002	protein histidine kinase activity
APLC1_1431	COG4783	chaperone-mediated protein folding
APLC1_1432	COG3437	response regulator, receiver
APLC1_1433	COG4251	negative regulation of phosphorylation
APLC1_1434	COG4251	negative regulation of phosphorylation
APLC1_1438	COG1331	Highly conserved protein containing a thioredoxin domain
APLC1_1440	COG2267	carboxylic ester hydrolase activity
APLC1_1442	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APLC1_1443	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
APLC1_1445	COG0028	Belongs to the TPP enzyme family
APLC1_1447	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APLC1_1450	COG0438	transferase activity, transferring glycosyl groups
APLC1_1451	COG1247	-acetyltransferase
APLC1_1468	COG0454	-acetyltransferase
APLC1_1486	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APLC1_1534	COG1716	ATPase activity
APLC1_1535	COG1716	ATPase activity
APLC1_1536	COG0363	glucosamine-6-phosphate deaminase activity
APLC1_1538	COG1716	ATPase activity
APLC1_1538	COG0842	Transport permease protein
APLC1_1538	COG1131	(ABC) transporter
APLC1_1539	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APLC1_1543	COG2226	methyltransferase
APLC1_1544	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APLC1_1545	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
APLC1_1546	COG0830	nickel cation binding
APLC1_1552	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APLC1_1552	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
APLC1_1553	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
APLC1_1559	COG2319	Wd-40 repeat
APLC1_1559	COG1672	PFAM Archaeal ATPase
APLC1_1560	COG1132	(ABC) transporter
APLC1_1573	COG2010	Cytochrome c
APLC1_1578	COG0617	tRNA 3'-terminal CCA addition
APLC1_1585	COG0181	hydroxymethylbilane synthase activity
APLC1_1595	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
APLC1_1599	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APLC1_1604	COG2205	protein histidine kinase activity
APLC1_1604	COG4999	Histidine kinase
APLC1_1604	COG3850	Histidine kinase
APLC1_1604	COG3437	response regulator, receiver
APLC1_1606	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APLC1_1607	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
APLC1_1609	COG1216	Glycosyl transferase, family 2
APLC1_1614	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
APLC1_1616	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
APLC1_1619	COG2010	Cytochrome c
APLC1_1622	COG1587	Uroporphyrinogen-III synthase
APLC1_1625	COG1715	Restriction endonuclease
APLC1_1626	COG0484	heat shock protein binding
APLC1_1628	COG0069	glutamate synthase activity
APLC1_1628	COG0067	glutamate synthase
APLC1_1628	COG0070	glutamate synthase
APLC1_1632	COG0316	Belongs to the HesB IscA family
APLC1_1638	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
APLC1_1641	COG0077	Prephenate dehydratase
APLC1_1641	COG1605	Chorismate mutase
APLC1_1643	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
APLC1_1644	COG1530	ribonuclease E activity
APLC1_1649	COG0436	Aminotransferase
APLC1_1669	COG1216	Glycosyl transferase, family 2
APLC1_1669	COG0438	transferase activity, transferring glycosyl groups
APLC1_1674	COG0724	RNA recognition motif
APLC1_1675	COG0616	signal peptide processing
APLC1_1680	COG0668	transmembrane transport
APLC1_1681	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APLC1_1682	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
APLC1_1707	COG0170	dolichyl monophosphate biosynthetic process
APLC1_1710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APLC1_1713	COG1606	tRNA processing
APLC1_1716	COG0484	heat shock protein binding
APLC1_1717	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
APLC1_1718	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
APLC1_1719	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
APLC1_1720	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
APLC1_1721	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
APLC1_1722	COG0837	glucose binding
APLC1_1723	COG2373	Large extracellular alpha-helical protein
APLC1_1724	COG2373	Large extracellular alpha-helical protein
APLC1_1726	COG1192	Involved in chromosome partitioning
APLC1_1729	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
APLC1_1731	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
APLC1_1732	COG0494	nUDIX hydrolase
APLC1_1733	COG0415	Belongs to the DNA photolyase family
APLC1_1734	COG0415	Belongs to the DNA photolyase family
APLC1_1737	COG0515	serine threonine protein kinase
APLC1_1738	COG0515	serine threonine protein kinase
APLC1_1738	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_1739	COG0515	serine threonine protein kinase
APLC1_1739	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APLC1_1740	COG0515	serine threonine protein kinase
APLC1_1740	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_1741	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_1741	COG0515	serine threonine protein kinase
APLC1_1742	COG0515	serine threonine protein kinase
APLC1_1742	COG2815	serine threonine protein kinase
APLC1_1744	COG0515	serine threonine protein kinase
APLC1_1745	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_1745	COG0515	serine threonine protein kinase
APLC1_1746	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_1746	COG0515	serine threonine protein kinase
APLC1_1747	COG0515	serine threonine protein kinase
APLC1_1747	COG3266	domain, Protein
APLC1_1755	COG0640	Transcriptional regulator
APLC1_1757	COG5002	protein histidine kinase activity
APLC1_1762	COG2211	Major facilitator Superfamily
APLC1_1765	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
APLC1_1766	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
APLC1_1768	COG0025	NhaP-type Na H and K H
APLC1_1778	COG3751	2OG-Fe(II) oxygenase superfamily
APLC1_1779	COG3751	2OG-Fe(II) oxygenase superfamily
APLC1_1780	COG3751	2OG-Fe(II) oxygenase superfamily
APLC1_1781	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
APLC1_1783	COG2843	Capsule synthesis protein
APLC1_1784	COG0676	glucose-6-phosphate 1-epimerase activity
APLC1_1786	COG0191	fructose-bisphosphate aldolase activity
APLC1_1792	COG0741	lytic transglycosylase activity
APLC1_1797	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APLC1_1798	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APLC1_1801	COG1131	(ABC) transporter
APLC1_1806	COG2202	Pas domain
APLC1_1806	COG2205	protein histidine kinase activity
APLC1_1807	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
APLC1_1808	COG1234	tRNA 3'-trailer cleavage
APLC1_1818	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
APLC1_1820	COG4245	von Willebrand factor, type A
APLC1_1835	COG3259	Nickel-dependent hydrogenase
APLC1_1836	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
APLC1_1838	COG1151	hydroxylamine reductase activity
APLC1_1839	COG1151	hydroxylamine reductase activity
APLC1_1841	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
APLC1_1842	COG0298	carbon dioxide binding
APLC1_1843	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
APLC1_1843	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
APLC1_1843	COG0674	pyruvate-flavodoxin oxidoreductase activity
APLC1_1843	COG1013	pyruvate-flavodoxin oxidoreductase activity
APLC1_1844	COG0167	dihydroorotate dehydrogenase activity
APLC1_1846	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APLC1_1853	COG0828	Belongs to the bacterial ribosomal protein bS21 family
APLC1_1854	COG2205	protein histidine kinase activity
APLC1_1873	COG0542	response to heat
APLC1_1886	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APLC1_1887	COG0457	Tetratricopeptide repeat
APLC1_1893	COG2198	Histidine kinase
APLC1_1893	COG0784	Response regulator, receiver
APLC1_1893	COG5002	protein histidine kinase activity
APLC1_1894	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APLC1_1894	COG2205	protein histidine kinase activity
APLC1_1898	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APLC1_1901	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APLC1_1902	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APLC1_1903	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
APLC1_1904	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
APLC1_1906	COG2340	Cysteine-rich secretory protein family
APLC1_1912	COG1074	ATP-dependent DNA helicase activity
APLC1_1916	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
APLC1_1917	COG0297	glycogen (starch) synthase activity
APLC1_1918	COG0297	glycogen (starch) synthase activity
APLC1_1926	COG3335	DDE superfamily endonuclease
APLC1_1958	COG0445	tRNA wobble uridine modification
APLC1_1961	COG1215	transferase activity, transferring glycosyl groups
APLC1_1983	COG0180	Tryptophanyl-tRNA synthetase
APLC1_1984	COG0180	Tryptophanyl-tRNA synthetase
APLC1_1985	COG4999	Histidine kinase
APLC1_1985	COG3850	Histidine kinase
APLC1_1985	COG3437	response regulator, receiver
APLC1_1985	COG2205	protein histidine kinase activity
APLC1_1986	COG0745	RESPONSE REGULATOR receiver
APLC1_1987	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
APLC1_1989	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
APLC1_1991	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
APLC1_1994	COG1305	Transglutaminase-like
APLC1_1997	COG3335	DDE superfamily endonuclease
APLC1_1998	COG1028	Short-chain dehydrogenase reductase Sdr
APLC1_2003	COG3335	DDE superfamily endonuclease
APLC1_2004	COG3335	DDE superfamily endonuclease
APLC1_2022	COG3850	Histidine kinase
APLC1_2022	COG4999	Histidine kinase
APLC1_2022	COG3437	response regulator, receiver
APLC1_2022	COG2205	protein histidine kinase activity
APLC1_2024	COG0492	ferredoxin-NADP+ reductase activity
APLC1_2026	COG1028	Short-chain dehydrogenase reductase Sdr
APLC1_2027	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APLC1_2029	COG4636	protein conserved in cyanobacteria
APLC1_2030	COG4636	protein conserved in cyanobacteria
APLC1_2035	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APLC1_2036	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
APLC1_2039	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APLC1_2040	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APLC1_2041	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
APLC1_2045	COG0024	Methionine aminopeptidase
APLC1_2046	COG0745	RESPONSE REGULATOR receiver
APLC1_2051	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APLC1_2054	COG3757	hydrolase, family 25
APLC1_2055	COG2226	methyltransferase
APLC1_2056	COG0492	ferredoxin-NADP+ reductase activity
APLC1_2058	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APLC1_2059	COG1012	belongs to the aldehyde dehydrogenase family
APLC1_2061	COG0179	Fumarylacetoacetate (FAA) hydrolase
APLC1_2062	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
APLC1_2063	COG0519	Catalyzes the synthesis of GMP from XMP
APLC1_2063	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APLC1_2064	COG0518	GMP synthase (glutamine-hydrolyzing) activity
APLC1_2064	COG0519	Catalyzes the synthesis of GMP from XMP
APLC1_2067	COG2239	Acts as a magnesium transporter
APLC1_2069	COG1285	pathogenesis
APLC1_2070	COG0366	Alpha amylase catalytic
APLC1_2071	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APLC1_2073	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APLC1_2077	COG0745	RESPONSE REGULATOR receiver
APLC1_2081	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APLC1_2082	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
APLC1_2083	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
APLC1_2084	COG1546	Belongs to the CinA family
APLC1_2084	COG1058	Belongs to the CinA family
APLC1_2086	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
APLC1_2090	COG1480	7TM receptor with intracellular HD hydrolase
APLC1_2091	COG1480	7TM receptor with intracellular HD hydrolase
APLC1_2093	COG0495	leucyl-tRNA aminoacylation
APLC1_2097	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APLC1_2098	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
APLC1_2100	COG0564	pseudouridine synthase activity
APLC1_2105	COG0116	Belongs to the methyltransferase superfamily
APLC1_2108	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
APLC1_2114	COG0123	including yeast histone deacetylase and acetoin utilization protein
APLC1_2117	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
APLC1_2118	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
APLC1_2121	COG0450	alkyl hydroperoxide reductase
APLC1_2122	COG2133	pyrroloquinoline quinone binding
APLC1_2123	COG2267	carboxylic ester hydrolase activity
APLC1_2124	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
APLC1_2136	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
APLC1_2137	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
APLC1_2138	COG3842	ATPase activity
APLC1_2140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APLC1_2141	COG3437	response regulator, receiver
APLC1_2141	COG4999	Histidine kinase
APLC1_2141	COG3850	Histidine kinase
APLC1_2141	COG2205	protein histidine kinase activity
APLC1_2143	COG2205	protein histidine kinase activity
APLC1_2146	COG0504	CTP synthase activity
APLC1_2147	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APLC1_2150	COG1196	nuclear chromosome segregation
APLC1_2154	COG0653	protein targeting
APLC1_2157	COG1715	Restriction endonuclease
APLC1_2164	COG0024	Methionine aminopeptidase
APLC1_2166	COG2202	Pas domain
APLC1_2166	COG3920	Histidine kinase
APLC1_2167	COG0673	inositol 2-dehydrogenase activity
APLC1_2173	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
APLC1_2175	COG1555	photosystem II stabilization
APLC1_2178	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
APLC1_2179	COG1217	gtp-binding protein TYPA
APLC1_2182	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
APLC1_2183	COG0589	response to stress
APLC1_2187	COG2319	Wd-40 repeat
APLC1_2187	COG3903	Transcriptional regulator
APLC1_2195	COG2226	methyltransferase
APLC1_2196	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APLC1_2197	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
APLC1_2199	COG0402	S-adenosylhomocysteine deaminase activity
APLC1_2201	COG1361	Conserved repeat domain
APLC1_2201	COG2911	Protein conserved in bacteria
APLC1_2201	COG3266	domain, Protein
APLC1_2205	COG1175	transmembrane transport
APLC1_2206	COG0659	secondary active sulfate transmembrane transporter activity
APLC1_2207	COG0659	secondary active sulfate transmembrane transporter activity
APLC1_2208	COG0659	secondary active sulfate transmembrane transporter activity
APLC1_2209	COG0659	secondary active sulfate transmembrane transporter activity
APLC1_2213	COG1022	Amp-dependent synthetase and ligase
APLC1_2215	COG0508	dehydrogenase complex catalyzes the overall conversion of
APLC1_2218	COG0523	cobalamin synthesis protein
APLC1_2220	COG0302	gtp cyclohydrolase
APLC1_2235	COG0745	RESPONSE REGULATOR receiver
APLC1_2255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APLC1_2258	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
APLC1_2282	COG0483	inositol monophosphate 1-phosphatase activity
APLC1_2285	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
APLC1_2285	COG0617	tRNA 3'-terminal CCA addition
APLC1_2285	COG0517	IMP dehydrogenase activity
APLC1_2286	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
APLC1_2286	COG0617	tRNA 3'-terminal CCA addition
APLC1_2286	COG0517	IMP dehydrogenase activity
APLC1_2293	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APLC1_2293	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
APLC1_2294	COG1733	regulation of RNA biosynthetic process
APLC1_2295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APLC1_2295	COG0574	Belongs to the PEP-utilizing enzyme family
APLC1_2305	COG0723	plastoquinol--plastocyanin reductase activity
APLC1_2306	COG3258	Cytochrome c
APLC1_2307	COG0596	Alpha beta hydrolase
APLC1_2328	COG0321	lipoyl(octanoyl) transferase activity
APLC1_2332	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APLC1_2345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
APLC1_2347	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
APLC1_2351	COG3852	Histidine kinase
APLC1_2357	COG0003	Pfam Anion-transporting ATPase
APLC1_2376	COG2052	Domain of unknown function (DUF370)
APLC1_2377	COG0194	GDP metabolic process
APLC1_2378	COG2304	oxidoreductase activity
APLC1_2379	COG0740	serine-type endopeptidase activity
APLC1_2380	COG0740	serine-type endopeptidase activity
APLC1_2381	COG0740	serine-type endopeptidase activity
APLC1_2382	COG0740	serine-type endopeptidase activity
APLC1_2383	COG0484	heat shock protein binding
APLC1_2389	COG1028	Short-chain dehydrogenase reductase Sdr
APLC1_2393	COG1132	(ABC) transporter
APLC1_2396	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
APLC1_2396	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
APLC1_2397	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
APLC1_2397	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
APLC1_2399	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APLC1_2400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APLC1_2403	COG0515	serine threonine protein kinase
APLC1_2403	COG3266	domain, Protein
APLC1_2404	COG2319	Wd-40 repeat
APLC1_2405	COG3659	wide pore channel activity
APLC1_2408	COG0745	RESPONSE REGULATOR receiver
APLC1_2412	COG1234	tRNA 3'-trailer cleavage
APLC1_2414	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
APLC1_2417	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
APLC1_2418	COG0193	aminoacyl-tRNA hydrolase activity
APLC1_2422	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
APLC1_2424	COG0514	ATP-dependent DNA helicase (RecQ)
APLC1_2425	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
APLC1_2427	COG0163	prenyltransferase activity
APLC1_2428	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
APLC1_2431	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APLC1_2432	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APLC1_2433	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APLC1_2434	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
APLC1_2435	COG0123	including yeast histone deacetylase and acetoin utilization protein
APLC1_2436	COG0556	nucleotide-excision repair
APLC1_2437	COG0534	Mate efflux family protein
APLC1_2438	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APLC1_2450	COG1337	RAMP superfamily
APLC1_2452	COG1332	CRISPR-associated RAMP protein, Csm5 family
APLC1_2471	COG2815	serine threonine protein kinase
APLC1_2471	COG0515	serine threonine protein kinase
APLC1_2481	COG1518	maintenance of DNA repeat elements
APLC1_2486	COG0497	DNA recombination
APLC1_2487	COG0497	DNA recombination
APLC1_2488	COG0167	dihydroorotate dehydrogenase activity
APLC1_2491	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APLC1_2492	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
APLC1_2494	COG0765	amino acid transport
APLC1_2495	COG4597	amino acid ABC transporter
APLC1_2497	COG3842	ATPase activity
APLC1_2499	COG3239	Fatty acid desaturase
APLC1_2522	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APLC1_2536	COG0542	response to heat
APLC1_2538	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APLC1_2539	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APLC1_2540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APLC1_2541	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APLC1_2541	COG1116	anion transmembrane transporter activity
APLC1_2542	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APLC1_2542	COG1116	anion transmembrane transporter activity
APLC1_2543	COG1116	anion transmembrane transporter activity
APLC1_2597	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APLC1_2597	COG0426	domain, Protein
APLC1_2598	COG0426	domain, Protein
APLC1_2598	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
APLC1_2601	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APLC1_2607	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
APLC1_2609	COG3956	TIGRFAM MazG family protein
APLC1_2616	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APLC1_2619	COG0398	Pfam SNARE associated Golgi protein
APLC1_2621	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
APLC1_2623	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APLC1_2624	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APLC1_2625	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APLC1_2626	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
APLC1_2627	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
APLC1_2628	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APLC1_2633	COG0530	calcium, potassium:sodium antiporter activity
APLC1_2634	COG0018	arginyl-trna synthetase
APLC1_2644	COG3437	response regulator, receiver
APLC1_2644	COG3850	Histidine kinase
APLC1_2644	COG4999	Histidine kinase
APLC1_2644	COG2205	protein histidine kinase activity
APLC1_2645	COG2205	protein histidine kinase activity
APLC1_2645	COG0784	Response regulator, receiver
APLC1_2645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APLC1_2645	COG2198	Histidine kinase
APLC1_2647	COG1490	D-aminoacyl-tRNA deacylase activity
APLC1_2648	COG0523	cobalamin synthesis protein
APLC1_2649	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APLC1_2667	COG0675	Transposase, IS605 OrfB family
APLC1_2674	COG0438	transferase activity, transferring glycosyl groups
APLC1_2677	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
APLC1_2686	COG0583	DNA-binding transcription factor activity
APLC1_2703	COG3335	DDE superfamily endonuclease
APLC1_2715	COG0515	serine threonine protein kinase
APLC1_2715	COG3266	domain, Protein
APLC1_2716	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_2716	COG0515	serine threonine protein kinase
APLC1_2718	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APLC1_2721	COG1115	amino acid carrier protein
APLC1_2725	COG2319	Wd-40 repeat
APLC1_2725	COG4249	Peptidase C14 caspase catalytic subunit p20
APLC1_2732	COG0464	growth
APLC1_2740	COG0515	serine threonine protein kinase
APLC1_2750	COG0515	serine threonine protein kinase
APLC1_2752	COG0443	Heat shock 70 kDa protein
APLC1_2758	COG0515	serine threonine protein kinase
APLC1_2759	COG1845	cytochrome c oxidase, subunit III
APLC1_2760	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
APLC1_2762	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
APLC1_2764	COG0109	protoheme IX farnesyltransferase activity
APLC1_2766	COG2203	Gaf domain
APLC1_2766	COG3706	GGDEF domain
APLC1_2766	COG5001	Diguanylate cyclase
APLC1_2766	COG4251	negative regulation of phosphorylation
APLC1_2767	COG4251	negative regulation of phosphorylation
APLC1_2768	COG2205	protein histidine kinase activity
APLC1_2768	COG2198	Histidine kinase
APLC1_2768	COG0784	Response regulator, receiver
APLC1_2769	COG2203	Gaf domain
APLC1_2769	COG3706	GGDEF domain
APLC1_2769	COG5001	Diguanylate cyclase
APLC1_2769	COG4251	negative regulation of phosphorylation
APLC1_2770	COG1672	PFAM Archaeal ATPase
APLC1_2770	COG2319	Wd-40 repeat
APLC1_2772	COG3659	wide pore channel activity
APLC1_2773	COG3659	wide pore channel activity
APLC1_2783	COG0439	Biotin carboxylase
APLC1_2784	COG0439	Biotin carboxylase
APLC1_2794	COG1361	Conserved repeat domain
APLC1_2794	COG3266	domain, Protein
APLC1_2794	COG2911	Protein conserved in bacteria
APLC1_2800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APLC1_2801	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
APLC1_2835	COG4585	Histidine kinase
APLC1_2836	COG2197	response regulator
APLC1_2844	COG1074	ATP-dependent DNA helicase activity
APLC1_2846	COG0210	DNA helicase
APLC1_2848	COG0515	serine threonine protein kinase
APLC1_2848	COG3266	domain, Protein
APLC1_2849	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APLC1_2850	COG2208	phosphoserine phosphatase activity
APLC1_2850	COG2770	Histidine kinase
APLC1_2852	COG2217	Heavy metal translocating P-type atpase
APLC1_2853	COG0505	Belongs to the CarA family
APLC1_2855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APLC1_2871	COG4956	integral membrane protein (PIN domain superfamily)
APLC1_2876	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
APLC1_2877	COG0149	triose-phosphate isomerase activity
APLC1_2884	COG0352	thiamine-phosphate diphosphorylase activity
APLC1_2890	COG1088	dTDP-glucose 4,6-dehydratase activity
APLC1_2892	COG2843	Capsule synthesis protein
APLC1_2895	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
APLC1_2898	COG1116	anion transmembrane transporter activity
APLC1_2898	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APLC1_2899	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APLC1_2901	COG4172	Belongs to the ABC transporter superfamily
APLC1_2902	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
APLC1_2903	COG0511	ligase activity, forming carbon-carbon bonds
APLC1_2905	COG3608	succinylglutamate desuccinylase aspartoacylase
APLC1_2907	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APLC1_2907	COG4191	Histidine kinase
APLC1_2911	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
APLC1_2913	COG0720	synthase
APLC1_2925	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
APLC1_2928	COG0405	Gamma-glutamyltransferase
APLC1_2934	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
APLC1_2935	COG0291	Belongs to the bacterial ribosomal protein bL35 family
APLC1_2936	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
APLC1_2938	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
APLC1_2941	COG1649	PFAM Uncharacterised BCR, COG1649
APLC1_2942	COG1215	transferase activity, transferring glycosyl groups
APLC1_2948	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
APLC1_2949	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APLC1_2950	COG1136	(ABC) transporter
APLC1_2950	COG0577	efflux transmembrane transporter activity
APLC1_2951	COG2385	sporulation resulting in formation of a cellular spore
APLC1_2952	COG2183	response to ionizing radiation
APLC1_2953	COG2183	response to ionizing radiation
APLC1_2958	COG2267	carboxylic ester hydrolase activity
APLC1_2960	COG3540	Alkaline phosphatase
APLC1_2962	COG0596	Alpha beta hydrolase
APLC1_2963	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APLC1_2966	COG0572	uridine kinase
APLC1_2971	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APLC1_2972	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
APLC1_2973	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
APLC1_2975	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
APLC1_2977	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APLC1_2978	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APLC1_2983	COG0702	epimerase
APLC1_2984	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APLC1_2991	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
APLC1_2992	COG2226	methyltransferase
APLC1_2993	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
APLC1_2995	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
APLC1_2996	COG0052	Belongs to the universal ribosomal protein uS2 family
APLC1_3001	COG1002	Type II restriction enzyme, methylase subunits
APLC1_3002	COG2852	Protein conserved in bacteria
APLC1_3008	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APLC1_3010	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APLC1_3012	COG1061	Type III restriction enzyme res subunit
APLC1_3014	COG0285	dihydrofolate synthase activity
APLC1_3017	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
APLC1_3018	COG0133	tryptophan synthase activity
APLC1_3027	COG0251	oxidation-reduction process
APLC1_3030	COG1404	Belongs to the peptidase S8 family
APLC1_3037	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
APLC1_3038	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
APLC1_3039	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
APLC1_3040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APLC1_3040	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APLC1_3041	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
APLC1_3041	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
APLC1_3042	COG0726	polysaccharide deacetylase
APLC1_3044	COG0314	molybdopterin synthase activity
APLC1_3045	COG1595	DNA-templated transcription, initiation
APLC1_3050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
APLC1_3051	COG1983	PspC domain protein
APLC1_3052	COG2081	HI0933 family
APLC1_3068	COG0632	four-way junction helicase activity
APLC1_3077	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
APLC1_3077	COG0758	DNA mediated transformation
APLC1_3078	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
APLC1_3079	COG0859	PFAM glycosyl transferase family 9
APLC1_3081	COG1968	undecaprenyl-diphosphatase activity
APLC1_3083	COG0860	N-Acetylmuramoyl-L-alanine amidase
APLC1_3084	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APLC1_3086	COG0596	Alpha beta hydrolase
APLC1_3087	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
APLC1_3088	COG0515	serine threonine protein kinase
APLC1_3088	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_3093	COG0475	glutathione-regulated potassium exporter activity
APLC1_3093	COG0589	response to stress
APLC1_3094	COG0751	glycine-tRNA ligase activity
APLC1_3096	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_3096	COG0515	serine threonine protein kinase
APLC1_3100	COG1316	TRANSCRIPTIONal
APLC1_3102	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
APLC1_3111	COG1175	transmembrane transport
APLC1_3114	COG4581	dead DEAH box helicase
APLC1_3115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APLC1_3117	COG0649	NAD binding
APLC1_3118	COG0275	rRNA processing
APLC1_3122	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
APLC1_3127	COG1598	PFAM Uncharacterised protein family UPF0150
APLC1_3129	COG0326	Molecular chaperone. Has ATPase activity
APLC1_3134	COG1049	propionate catabolic process, 2-methylcitrate cycle
APLC1_3135	COG0784	Response regulator, receiver
APLC1_3135	COG4191	Histidine kinase
APLC1_3136	COG5001	Diguanylate cyclase
APLC1_3136	COG3300	MHYT domain
APLC1_3137	COG0489	protein tyrosine kinase activity
APLC1_3140	COG3976	FMN-binding domain protein
APLC1_3140	COG1053	succinate dehydrogenase
APLC1_3143	COG0312	modulator of DNA gyrase
APLC1_3144	COG2010	Cytochrome c
APLC1_3145	COG5001	Diguanylate cyclase
APLC1_3145	COG3706	GGDEF domain
APLC1_3145	COG4251	negative regulation of phosphorylation
APLC1_3145	COG2203	Gaf domain
APLC1_3147	COG0233	cytoplasmic translational termination
APLC1_3148	COG0528	UMP kinase activity
APLC1_3150	COG0675	Transposase, IS605 OrfB family
APLC1_3151	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APLC1_3152	COG0010	Belongs to the arginase family
APLC1_3154	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APLC1_3161	COG0728	peptidoglycan biosynthetic process
APLC1_3164	COG0318	PFAM AMP-dependent synthetase and ligase
APLC1_3168	COG0574	Belongs to the PEP-utilizing enzyme family
APLC1_3168	COG3848	Pyruvate phosphate dikinase
APLC1_3170	COG0315	cyclic pyranopterin monophosphate synthase activity
APLC1_3171	COG1252	NADH dehydrogenase
APLC1_3183	COG4968	Prepilin-type N-terminal cleavage methylation domain
APLC1_3192	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
APLC1_3196	COG3706	GGDEF domain
APLC1_3199	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
APLC1_3199	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
APLC1_3202	COG0793	Belongs to the peptidase S41A family
APLC1_3203	COG0131	Imidazoleglycerol-phosphate dehydratase
APLC1_3204	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
APLC1_3205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APLC1_3207	COG4372	Transposase
APLC1_3214	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APLC1_3218	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
APLC1_3220	COG0840	transmembrane signaling receptor activity
APLC1_3221	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APLC1_3223	COG0333	Belongs to the bacterial ribosomal protein bL32 family
APLC1_3224	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
APLC1_3226	COG0792	nuclease activity
APLC1_3229	COG0675	Transposase, IS605 OrfB family
APLC1_3231	COG0572	uridine kinase
APLC1_3233	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
APLC1_3236	COG0583	DNA-binding transcription factor activity
APLC1_3237	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APLC1_3238	COG1012	belongs to the aldehyde dehydrogenase family
APLC1_3239	COG1012	belongs to the aldehyde dehydrogenase family
APLC1_3240	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APLC1_3240	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
APLC1_3240	COG0506	proline dehydrogenase activity
APLC1_3243	COG1254	Belongs to the acylphosphatase family
APLC1_3244	COG0436	Aminotransferase
APLC1_3245	COG0308	aminopeptidase N
APLC1_3258	COG0339	signal peptide processing
APLC1_3259	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APLC1_3259	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
APLC1_3260	COG2814	Major facilitator Superfamily
APLC1_3261	COG3852	Histidine kinase
APLC1_3265	COG1215	transferase activity, transferring glycosyl groups
APLC1_3272	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APLC1_3274	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
APLC1_3276	COG3659	wide pore channel activity
APLC1_3278	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
APLC1_3282	COG0686	Belongs to the AlaDH PNT family
APLC1_3284	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
APLC1_3285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APLC1_3314	COG0107	imidazoleglycerol-phosphate synthase activity
APLC1_3315	COG1115	amino acid carrier protein
APLC1_3323	COG0768	penicillin binding
APLC1_3325	COG0772	Belongs to the SEDS family
APLC1_3334	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
APLC1_3335	COG1672	PFAM Archaeal ATPase
APLC1_3336	COG0724	RNA recognition motif
APLC1_3342	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
APLC1_3349	COG0513	Belongs to the DEAD box helicase family
APLC1_3352	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APLC1_3352	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
APLC1_3353	COG0443	Heat shock 70 kDa protein
APLC1_3354	COG0443	Heat shock 70 kDa protein
APLC1_3355	COG0484	heat shock protein binding
APLC1_3368	COG0165	Argininosuccinate lyase
APLC1_3370	COG2208	phosphoserine phosphatase activity
APLC1_3371	COG0552	protein localization to endoplasmic reticulum
APLC1_3372	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
APLC1_3375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
APLC1_3376	COG0588	phosphoglycerate mutase activity
APLC1_3378	COG4191	Histidine kinase
APLC1_3379	COG2205	protein histidine kinase activity
APLC1_3379	COG2202	Pas domain
APLC1_3380	COG0784	Response regulator, receiver
APLC1_3380	COG2198	Histidine kinase
APLC1_3380	COG5002	protein histidine kinase activity
APLC1_3385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
APLC1_3387	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
APLC1_3391	COG0475	glutathione-regulated potassium exporter activity
APLC1_3393	COG0440	acetolactate synthase activity
APLC1_3395	COG2226	methyltransferase
APLC1_3396	COG0189	ligase activity
APLC1_3397	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APLC1_3400	COG1832	CoA-binding protein
APLC1_3401	COG1131	(ABC) transporter
APLC1_3404	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
APLC1_3405	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
APLC1_3410	COG2911	Protein conserved in bacteria
APLC1_3410	COG3266	domain, Protein
APLC1_3410	COG1361	Conserved repeat domain
APLC1_3420	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APLC1_3421	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APLC1_3430	COG1943	Transposase
APLC1_3433	COG1575	Belongs to the MenA family. Type 1 subfamily
APLC1_3434	COG2124	cytochrome p450
APLC1_3436	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
APLC1_3437	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APLC1_3438	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
APLC1_3439	COG0812	UDP-N-acetylmuramate dehydrogenase activity
APLC1_3441	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
APLC1_3442	COG0006	proline dipeptidase activity
APLC1_3446	COG0745	RESPONSE REGULATOR receiver
APLC1_3449	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APLC1_3453	COG0824	Thioesterase
APLC1_3454	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
APLC1_3465	COG0114	fumarate hydratase activity
APLC1_3466	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
APLC1_3469	COG3659	wide pore channel activity
APLC1_3471	COG1840	ABC-type Fe3 transport system, periplasmic component
APLC1_3473	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
APLC1_3479	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
APLC1_3481	COG0039	L-malate dehydrogenase activity
APLC1_3509	COG0515	serine threonine protein kinase
APLC1_3509	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_3510	COG0515	serine threonine protein kinase
APLC1_3511	COG1262	PFAM Formylglycine-generating sulfatase enzyme
APLC1_3512	COG0515	serine threonine protein kinase
APLC1_3512	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_3513	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_3513	COG0515	serine threonine protein kinase
APLC1_3514	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_3514	COG0515	serine threonine protein kinase
APLC1_3517	COG0791	NLP P60 protein
APLC1_3518	COG3266	domain, Protein
APLC1_3518	COG0515	serine threonine protein kinase
APLC1_3519	COG0515	serine threonine protein kinase
APLC1_3519	COG3266	domain, Protein
APLC1_3521	COG0820	rRNA (adenine-C2-)-methyltransferase activity
APLC1_3523	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
APLC1_3535	COG1160	GTP binding
APLC1_3537	COG3264	Mechanosensitive ion channel
APLC1_3537	COG1196	nuclear chromosome segregation
APLC1_3539	COG4208	sulfate ABC transporter
APLC1_3540	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
APLC1_3541	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
APLC1_3544	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
APLC1_3546	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APLC1_3547	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APLC1_3548	COG1045	serine acetyltransferase
APLC1_3549	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APLC1_3550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APLC1_3552	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
APLC1_3552	COG1042	CoA-binding domain protein
APLC1_3552	COG0045	succinate-CoA ligase (ADP-forming) activity
APLC1_3554	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APLC1_3556	COG0306	phosphate transporter
APLC1_3562	COG3266	domain, Protein
APLC1_3562	COG2911	Protein conserved in bacteria
APLC1_3562	COG1361	Conserved repeat domain
APLC1_3563	COG2226	methyltransferase
APLC1_3565	COG0058	SHG alpha-glucan phosphorylase activity
APLC1_3568	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
APLC1_3572	COG3621	Patatin-like phospholipase
APLC1_3580	COG2226	methyltransferase
APLC1_3587	COG0670	Belongs to the BI1 family
APLC1_3590	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
APLC1_3593	COG0732	type I restriction modification DNA specificity domain
APLC1_3605	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
APLC1_3608	COG3266	domain, Protein
APLC1_3608	COG0515	serine threonine protein kinase
APLC1_3610	COG0515	serine threonine protein kinase
APLC1_3615	COG1122	ATPase activity
APLC1_3617	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
APLC1_3618	COG0310	cobalt ion transport
APLC1_3620	COG1216	Glycosyl transferase, family 2
APLC1_3622	COG0137	argininosuccinate synthase activity
APLC1_3624	COG5322	oxidoreductase activity
APLC1_3629	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
APLC1_3630	COG0395	ABC-type sugar transport system, permease component
APLC1_3632	COG0438	transferase activity, transferring glycosyl groups
APLC1_3632	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
APLC1_3634	COG1012	belongs to the aldehyde dehydrogenase family
APLC1_3634	COG1454	alcohol dehydrogenase
APLC1_3635	COG0651	ATP synthesis coupled electron transport
APLC1_3636	COG1006	Multisubunit Na H antiporter MnhC subunit
APLC1_3637	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
APLC1_3643	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APLC1_3648	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
APLC1_3649	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
APLC1_3650	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
APLC1_3652	COG5002	protein histidine kinase activity
APLC1_3652	COG0784	Response regulator, receiver
APLC1_3652	COG2205	protein histidine kinase activity
APLC1_3655	COG4251	negative regulation of phosphorylation
APLC1_3655	COG3706	GGDEF domain
APLC1_3655	COG2203	Gaf domain
APLC1_3655	COG5001	Diguanylate cyclase
APLC1_3664	COG0189	ligase activity
APLC1_3664	COG4067	protein conserved in archaea
APLC1_3668	COG1176	ABC-type spermidine putrescine transport system, permease component I
APLC1_3670	COG1177	transmembrane transport
APLC1_3672	COG0469	pyruvate kinase activity
APLC1_3673	COG0305	Participates in initiation and elongation during chromosome replication
APLC1_3673	COG1372	Participates in initiation and elongation during chromosome replication
APLC1_3674	COG0359	binds to the 23S rRNA
APLC1_3675	COG1126	abc transporter atp-binding protein
APLC1_3678	COG1131	(ABC) transporter
APLC1_3679	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
APLC1_3683	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APLC1_3684	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
APLC1_3690	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
APLC1_3691	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
APLC1_3693	COG2252	PERMEase
APLC1_3694	COG2203	Gaf domain
APLC1_3695	COG0628	permease
APLC1_3696	COG0697	spore germination
APLC1_3697	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APLC1_3699	COG0302	gtp cyclohydrolase
APLC1_3700	COG1028	Short-chain dehydrogenase reductase Sdr
APLC1_3701	COG0825	malonyl-CoA metabolic process
APLC1_3703	COG0678	peroxiredoxin activity
APLC1_3704	COG0515	serine threonine protein kinase
APLC1_3704	COG3266	domain, Protein
APLC1_3708	COG0515	serine threonine protein kinase
APLC1_3708	COG2815	serine threonine protein kinase
APLC1_3711	COG3937	granule-associated protein
APLC1_3712	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APLC1_3714	COG0631	protein serine/threonine phosphatase activity
APLC1_3715	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APLC1_3716	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
APLC1_3722	COG1070	Carbohydrate kinase
APLC1_3723	COG3409	Peptidoglycan-binding domain 1 protein
APLC1_3723	COG3773	Cell wall hydrolase
APLC1_3724	COG0151	Belongs to the GarS family
APLC1_3725	COG5002	protein histidine kinase activity
APLC1_3736	COG0429	hydrolase of the alpha beta-hydrolase fold
APLC1_3737	COG0515	serine threonine protein kinase
APLC1_3737	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_3738	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
APLC1_3758	COG0702	epimerase
APLC1_3772	COG1132	(ABC) transporter
APLC1_3777	COG0463	Glycosyl transferase, family 2
APLC1_3778	COG3118	belongs to the thioredoxin family
APLC1_3779	COG1028	Short-chain dehydrogenase reductase Sdr
APLC1_3780	COG0459	protein refolding
APLC1_3781	COG0745	RESPONSE REGULATOR receiver
APLC1_3782	COG2205	protein histidine kinase activity
APLC1_3782	COG0745	RESPONSE REGULATOR receiver
APLC1_3782	COG4191	Histidine kinase
APLC1_3786	COG0571	ribonuclease III activity
APLC1_3787	COG4245	von Willebrand factor, type A
APLC1_3789	COG4251	negative regulation of phosphorylation
APLC1_3789	COG5001	Diguanylate cyclase
APLC1_3789	COG3706	GGDEF domain
APLC1_3789	COG2203	Gaf domain
APLC1_3794	COG0840	transmembrane signaling receptor activity
APLC1_3795	COG0142	geranyltranstransferase activity
APLC1_3800	COG0602	queuosine metabolic process
APLC1_3801	COG0023	Translation Initiation Factor
APLC1_3806	COG1496	oxidoreductase activity
APLC1_3808	COG0739	heme binding
APLC1_3813	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
APLC1_3814	COG0745	RESPONSE REGULATOR receiver
APLC1_3823	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APLC1_3829	COG2954	triphosphatase activity
APLC1_3833	COG2197	response regulator
APLC1_3835	COG0124	histidyl-tRNA synthetase
APLC1_3837	COG2319	Wd-40 repeat
APLC1_3837	COG4249	Peptidase C14 caspase catalytic subunit p20
APLC1_3837	COG2319	Wd-40 repeat
APLC1_3837	COG4249	Peptidase C14 caspase catalytic subunit p20
APLC1_3840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
APLC1_3841	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
APLC1_3843	COG2319	Wd-40 repeat
APLC1_3843	COG4249	Peptidase C14 caspase catalytic subunit p20
APLC1_3846	COG4249	Peptidase C14 caspase catalytic subunit p20
APLC1_3846	COG2319	Wd-40 repeat
APLC1_3849	COG2205	protein histidine kinase activity
APLC1_3853	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_3853	COG0515	serine threonine protein kinase
APLC1_3854	COG0072	phenylalanine-tRNA ligase activity
APLC1_3854	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
APLC1_3863	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APLC1_3866	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
APLC1_3870	COG2027	D-alanyl-D-alanine carboxypeptidase
APLC1_3872	COG0416	fatty acid biosynthetic process
APLC1_3873	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
APLC1_3874	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
APLC1_3875	COG5002	protein histidine kinase activity
APLC1_3890	COG3335	DDE superfamily endonuclease
APLC1_3899	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
APLC1_3902	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
APLC1_3905	COG3335	DDE superfamily endonuclease
APLC1_3918	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
APLC1_3940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APLC1_3941	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APLC1_3942	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
APLC1_3963	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
APLC1_3964	COG0436	Aminotransferase
APLC1_3965	COG1619	proteins homologs of microcin C7 resistance protein MccF
APLC1_3966	COG0384	phenazine biosynthesis protein PhzF
APLC1_3967	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APLC1_3977	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
APLC1_3978	COG0829	nickel cation binding
APLC1_3979	COG0831	urea catabolic process
APLC1_3980	COG0832	Belongs to the urease beta subunit family
APLC1_3981	COG0804	urea catabolic process
APLC1_3982	COG0804	urea catabolic process
APLC1_3983	COG3706	GGDEF domain
APLC1_3987	COG1649	PFAM Uncharacterised BCR, COG1649
APLC1_3990	COG1794	racemase activity, acting on amino acids and derivatives
APLC1_4002	COG0516	GMP reductase activity
APLC1_4004	COG3118	belongs to the thioredoxin family
APLC1_4006	COG0745	RESPONSE REGULATOR receiver
APLC1_4007	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
APLC1_4013	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
APLC1_4017	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
APLC1_4018	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
APLC1_4018	COG0140	phosphoribosyl-ATP diphosphatase activity
APLC1_4024	COG2308	Evidence 4 Homologs of previously reported genes of
APLC1_4026	COG0540	Belongs to the ATCase OTCase family
APLC1_4030	COG1132	(ABC) transporter
APLC1_4032	COG0443	Heat shock 70 kDa protein
APLC1_4036	COG0800	Aldolase
APLC1_4037	COG0435	Glutathione S-transferase
APLC1_4043	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
APLC1_4044	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
APLC1_4047	COG0747	negative chemotaxis
APLC1_4048	COG1691	(AIR) carboxylase
APLC1_4060	COG2204	response regulator
APLC1_4061	COG2203	Gaf domain
APLC1_4061	COG3706	GGDEF domain
APLC1_4061	COG4251	negative regulation of phosphorylation
APLC1_4061	COG5001	Diguanylate cyclase
APLC1_4065	COG3335	DDE superfamily endonuclease
APLC1_4074	COG0675	Transposase, IS605 OrfB family
APLC1_4080	COG0159	tryptophan synthase activity
APLC1_4083	COG0656	L-ascorbic acid biosynthetic process
APLC1_4091	COG0450	alkyl hydroperoxide reductase
APLC1_4092	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APLC1_4093	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
APLC1_4095	COG0542	response to heat
APLC1_4096	COG0346	lactoylglutathione lyase activity
APLC1_4104	COG1473	amidohydrolase
APLC1_4105	COG1473	amidohydrolase
APLC1_4120	COG3842	ATPase activity
APLC1_4125	COG0330	HflC and HflK could
APLC1_4127	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
APLC1_4128	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APLC1_4129	COG2815	serine threonine protein kinase
APLC1_4129	COG0515	serine threonine protein kinase
APLC1_4132	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APLC1_4133	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
APLC1_4136	COG0217	transcriptional regulatory protein
APLC1_4138	COG3264	Mechanosensitive ion channel
APLC1_4138	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
APLC1_4144	COG0675	Transposase, IS605 OrfB family
APLC1_4152	COG0668	transmembrane transport
APLC1_4153	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
APLC1_4156	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
APLC1_4158	COG1376	ErfK ybiS ycfS ynhG family protein
APLC1_4159	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APLC1_4162	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_4162	COG0515	serine threonine protein kinase
APLC1_4189	COG0788	formyltetrahydrofolate deformylase activity
APLC1_4192	COG2205	protein histidine kinase activity
APLC1_4193	COG2205	protein histidine kinase activity
APLC1_4201	COG0577	efflux transmembrane transporter activity
APLC1_4201	COG1136	(ABC) transporter
APLC1_4202	COG0577	efflux transmembrane transporter activity
APLC1_4202	COG1136	(ABC) transporter
APLC1_4204	COG0564	pseudouridine synthase activity
APLC1_4206	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
APLC1_4210	COG1597	lipid kinase activity
APLC1_4211	COG0419	ATPase involved in DNA repair
APLC1_4212	COG0058	SHG alpha-glucan phosphorylase activity
APLC1_4213	COG0058	SHG alpha-glucan phosphorylase activity
APLC1_4214	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
APLC1_4215	COG0251	oxidation-reduction process
APLC1_4216	COG0251	oxidation-reduction process
APLC1_4218	COG0251	oxidation-reduction process
APLC1_4221	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
APLC1_4221	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
APLC1_4226	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
APLC1_4232	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
APLC1_4233	COG2226	methyltransferase
APLC1_4234	COG3706	GGDEF domain
APLC1_4239	COG0488	(ABC) transporter
APLC1_4241	COG0784	Response regulator, receiver
APLC1_4241	COG2205	protein histidine kinase activity
APLC1_4242	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APLC1_4243	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APLC1_4246	COG1525	nuclease
APLC1_4248	COG0175	sulfate reduction
APLC1_4261	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
APLC1_4263	COG0463	Glycosyl transferase, family 2
APLC1_4270	COG2205	protein histidine kinase activity
APLC1_4270	COG0784	Response regulator, receiver
APLC1_4271	COG0126	phosphoglycerate kinase activity
APLC1_4272	COG0589	response to stress
APLC1_4274	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
APLC1_4279	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
APLC1_4285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
APLC1_4287	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
APLC1_4288	COG0284	orotidine-5'-phosphate decarboxylase activity
APLC1_4297	COG3344	reverse transcriptase
APLC1_4302	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APLC1_4302	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
APLC1_4304	COG1994	Peptidase M50
APLC1_4304	COG0517	IMP dehydrogenase activity
APLC1_4305	COG0095	Lipoate-protein ligase
APLC1_4309	COG2226	methyltransferase
APLC1_4317	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
APLC1_4322	COG5002	protein histidine kinase activity
APLC1_4329	COG0312	modulator of DNA gyrase
APLC1_4331	COG1704	LemA family
APLC1_4332	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
APLC1_4357	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
APLC1_4358	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
APLC1_4367	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APLC1_4382	COG2264	protein methyltransferase activity
APLC1_4383	COG0189	ligase activity
APLC1_4385	COG0436	Aminotransferase
APLC1_4386	COG0371	Dehydrogenase
APLC1_4395	COG2274	protein secretion by the type I secretion system
APLC1_4398	COG1216	Glycosyl transferase, family 2
APLC1_4402	COG0640	Transcriptional regulator
APLC1_4421	COG3335	DDE superfamily endonuclease
APLC1_4429	COG0745	RESPONSE REGULATOR receiver
APLC1_4431	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
APLC1_4432	COG4953	penicillin-binding protein 1C
APLC1_4434	COG1053	succinate dehydrogenase
APLC1_4436	COG0850	regulation of cytokinetic process
APLC1_4437	COG2894	cell division
APLC1_4438	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
APLC1_4442	COG1403	HNH endonuclease
APLC1_4444	COG2337	Toxic component of a toxin-antitoxin (TA) module
APLC1_4447	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
APLC1_4448	COG0355	proton-transporting ATP synthase activity, rotational mechanism
APLC1_4449	COG0443	Heat shock 70 kDa protein
APLC1_4450	COG0443	Heat shock 70 kDa protein
APLC1_4452	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
APLC1_4457	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APLC1_4460	COG3769	mannosylglycerate metabolic process
APLC1_4461	COG0750	zinc metalloprotease
APLC1_4462	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
APLC1_4463	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
APLC1_4466	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APLC1_4467	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
APLC1_4472	COG4243	Vitamin k epoxide reductase
APLC1_4473	COG0434	BtpA family
APLC1_4485	COG1216	Glycosyl transferase, family 2
APLC1_4485	COG0438	transferase activity, transferring glycosyl groups
APLC1_4492	COG1615	UPF0182 protein
APLC1_4495	COG3854	ATPases associated with a variety of cellular activities
APLC1_4499	COG5278	phosphoserine phosphatase activity
APLC1_4499	COG0840	transmembrane signaling receptor activity
APLC1_4500	COG0784	Response regulator, receiver
APLC1_4500	COG0643	Histidine kinase
APLC1_4500	COG2198	Histidine kinase
APLC1_4501	COG2201	protein-glutamate methylesterase activity
APLC1_4502	COG0745	RESPONSE REGULATOR receiver
APLC1_4504	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APLC1_4507	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APLC1_4508	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
APLC1_4512	COG0701	Predicted permease
APLC1_4516	COG3335	DDE superfamily endonuclease
APLC1_4538	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
APLC1_4550	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
APLC1_4551	COG0525	valine-tRNA ligase activity
APLC1_4553	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
APLC1_4555	COG3850	Histidine kinase
APLC1_4555	COG4999	Histidine kinase
APLC1_4555	COG2205	protein histidine kinase activity
APLC1_4555	COG3437	response regulator, receiver
APLC1_4559	COG1160	GTP binding
APLC1_4560	COG1090	epimerase
APLC1_4562	COG0297	glycogen (starch) synthase activity
APLC1_4563	COG0799	negative regulation of ribosome biogenesis
APLC1_4572	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
APLC1_4575	COG1116	anion transmembrane transporter activity
APLC1_4575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APLC1_4576	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
APLC1_4577	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
APLC1_4577	COG1116	anion transmembrane transporter activity
APLC1_4597	COG4279	zinc finger
APLC1_4600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APLC1_4601	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
APLC1_4604	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
APLC1_4604	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
APLC1_4606	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
APLC1_4610	COG2203	Gaf domain
APLC1_4610	COG3706	GGDEF domain
APLC1_4610	COG4251	negative regulation of phosphorylation
APLC1_4610	COG5001	Diguanylate cyclase
APLC1_4617	COG0824	Thioesterase
APLC1_4619	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
APLC1_4623	COG0457	Tetratricopeptide repeat
APLC1_4623	COG0463	Glycosyl transferase, family 2
APLC1_4635	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
APLC1_4649	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APLC1_4650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
APLC1_4651	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
APLC1_4660	COG1459	type II secretion system
APLC1_4662	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
APLC1_4663	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
APLC1_4664	COG0443	Heat shock 70 kDa protein
APLC1_4665	COG0484	heat shock protein binding
APLC1_4667	COG1162	GTPase activity
APLC1_4669	COG0243	molybdopterin cofactor binding
APLC1_4670	COG2223	nitrite transmembrane transporter activity
APLC1_4671	COG2223	nitrite transmembrane transporter activity
APLC1_4672	COG2223	nitrite transmembrane transporter activity
APLC1_4675	COG0402	S-adenosylhomocysteine deaminase activity
APLC1_4676	COG0402	S-adenosylhomocysteine deaminase activity
APLC1_4677	COG1596	polysaccharide export
APLC1_4688	COG1028	Short-chain dehydrogenase reductase Sdr
APLC1_4690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
APLC1_4694	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
APLC1_4723	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APLC1_4724	COG0719	Fe-S assembly protein
APLC1_4725	COG0719	Fe-S assembly protein
APLC1_4726	COG0396	ATPase activity
APLC1_4727	COG0719	Fe-S assembly protein
APLC1_4731	COG2255	four-way junction helicase activity
APLC1_4745	COG0460	homoserine dehydrogenase
APLC1_4746	COG0460	homoserine dehydrogenase
APLC1_4747	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
APLC1_4750	COG1295	ribonuclease BN
APLC1_4755	COG1121	(ABC) transporter
APLC1_4756	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APLC1_4757	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
APLC1_4764	COG0484	heat shock protein binding
APLC1_4766	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
APLC1_4767	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
APLC1_4768	COG0019	diaminopimelate decarboxylase activity
APLC1_4770	COG0542	response to heat
APLC1_4772	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
APLC1_4773	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
APLC1_4774	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
APLC1_4783	COG1473	amidohydrolase
APLC1_4786	COG0601	transmembrane transport
APLC1_4787	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
APLC1_4792	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
APLC1_4795	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APLC1_4797	COG0521	Mo-molybdopterin cofactor biosynthetic process
APLC1_4798	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
APLC1_4799	COG2154	pterin-4-alpha-carbinolamine dehydratase
APLC1_4800	COG2340	Cysteine-rich secretory protein family
APLC1_4803	COG2890	protein-(glutamine-N5) methyltransferase activity
APLC1_4806	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
APLC1_4810	COG1260	myo-inositol-1-phosphate synthase
APLC1_4816	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
APLC1_4829	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
APLC1_4830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APLC1_4831	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
APLC1_4833	COG0395	ABC-type sugar transport system, permease component
APLC1_4839	COG0489	protein tyrosine kinase activity
APLC1_4840	COG0408	coproporphyrinogen oxidase activity
APLC1_4846	COG0739	heme binding
APLC1_4847	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
APLC1_4848	COG0587	DNA-directed DNA polymerase activity
APLC1_4849	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APLC1_4850	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
APLC1_4852	COG1842	Phage shock protein A
APLC1_4853	COG1842	Phage shock protein A
APLC1_4856	COG2197	response regulator
APLC1_4860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APLC1_4861	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
APLC1_4865	COG0842	Transport permease protein
APLC1_4865	COG1131	(ABC) transporter
APLC1_4865	COG1716	ATPase activity
APLC1_4866	COG1716	ATPase activity
APLC1_4868	COG0675	Transposase, IS605 OrfB family
APLC1_4871	COG1215	transferase activity, transferring glycosyl groups
APLC1_4873	COG0110	maltose O-acetyltransferase activity
APLC1_4881	COG0457	Tetratricopeptide repeat
APLC1_4886	COG0642	Histidine kinase
APLC1_4889	COG1725	Transcriptional regulator
APLC1_4890	COG0412	Dienelactone hydrolase
APLC1_4891	COG0539	negative regulation of cytoplasmic translation
APLC1_4892	COG2971	BadF BadG BcrA BcrD
APLC1_4894	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
APLC1_4897	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
APLC1_4914	COG0515	serine threonine protein kinase
APLC1_4914	COG3266	domain, Protein
APLC1_4928	COG0542	response to heat
APLC1_4933	COG5002	protein histidine kinase activity
APLC1_4935	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
APLC1_4935	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
APLC1_4940	COG2217	Heavy metal translocating P-type atpase
APLC1_4941	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
APLC1_4943	COG1413	lyase activity
APLC1_4944	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
APLC1_4945	COG0237	dephospho-CoA kinase activity
APLC1_4949	COG0601	transmembrane transport
APLC1_4951	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APLC1_4952	COG0629	single-stranded DNA binding
APLC1_4953	COG5002	protein histidine kinase activity
APLC1_4956	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
APLC1_4959	COG0321	lipoyl(octanoyl) transferase activity
APLC1_4964	COG3335	DDE superfamily endonuclease
APLC1_4979	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
APLC1_4991	COG2192	nodulation
APLC1_4996	COG0277	FAD linked oxidase domain protein
APLC1_4996	COG0247	lactate metabolic process
APLC1_4998	COG0740	serine-type endopeptidase activity
APLC1_5000	COG0557	exoribonuclease II activity
APLC1_5002	COG0776	regulation of translation
APLC1_5003	COG1429	ligase activity, forming nitrogen-metal bonds
APLC1_5004	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
APLC1_5005	COG0569	domain protein
APLC1_5009	COG0501	Belongs to the peptidase M48B family
APLC1_5011	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
APLC1_5013	COG2911	Protein conserved in bacteria
APLC1_5013	COG3266	domain, Protein
APLC1_5013	COG1361	Conserved repeat domain
APLC1_5020	COG1216	Glycosyl transferase, family 2
APLC1_5020	COG0463	Glycosyl transferase, family 2
APLC1_5028	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
APLC1_5030	COG0438	transferase activity, transferring glycosyl groups
APLC1_5034	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
APLC1_5044	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APLC1_5046	COG0375	protein maturation
APLC1_5047	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
APLC1_5048	COG0205	6-phosphofructokinase activity
APLC1_5050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APLC1_5051	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APLC1_5074	COG1702	phosphate starvation-inducible protein PhoH
APLC1_5076	COG0228	four-way junction DNA binding
APLC1_5077	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
APLC1_5080	COG1122	ATPase activity
APLC1_5091	COG0516	GMP reductase activity
APLC1_5091	COG0517	IMP dehydrogenase activity
APLC1_5094	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
APLC1_5098	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
APLC1_5102	COG0215	cysteine-tRNA ligase activity
APLC1_5104	COG0523	cobalamin synthesis protein
APLC1_5105	COG2166	iron-sulfur cluster assembly
APLC1_5106	COG0113	porphobilinogen synthase activity
APLC1_5110	COG0004	ammonium transporteR
APLC1_5111	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
APLC1_5114	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
APLC1_5124	COG0596	Alpha beta hydrolase
APLC1_5126	COG0538	isocitrate dehydrogenase activity
APLC1_5128	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
APLC1_5129	COG2197	response regulator
APLC1_5130	COG0303	'Molybdopterin
APLC1_5132	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
APLC1_5139	COG2198	Histidine kinase
APLC1_5139	COG2205	protein histidine kinase activity
APLC1_5139	COG0784	Response regulator, receiver
APLC1_5142	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
APLC1_5144	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APLC1_5148	COG0512	Glutamine amidotransferase of anthranilate synthase
APLC1_5148	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
APLC1_5149	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
APLC1_5150	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
APLC1_5172	COG1045	serine acetyltransferase
APLC1_5176	COG0644	oxidoreductase
APLC1_5177	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
APLC1_5178	COG3536	Protein conserved in bacteria
APLC1_5183	COG3240	lipase activity
APLC1_5186	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APLC1_5188	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
APLC1_5192	COG4804	nuclease activity
APLC1_5194	COG3335	DDE superfamily endonuclease
APLC1_5196	COG3335	DDE superfamily endonuclease
APLC1_5200	COG2066	Belongs to the glutaminase family
APLC1_5207	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
APLC1_5209	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
APLC1_5210	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
APLC1_5215	COG0612	Peptidase, M16
APLC1_5216	COG0612	Peptidase, M16
APLC1_5217	COG1309	transcriptional regulator
APLC1_5235	COG1666	GTP binding
APLC1_5257	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APLC1_5258	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APLC1_5263	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
APLC1_5264	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APLC1_5265	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APLC1_5304	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APLC1_5311	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APLC1_5320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APLC1_5326	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
APLC1_5345	COG2066	Belongs to the glutaminase family
APLC1_5346	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
APLC1_5356	COG0589	response to stress
APLC1_5362	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APLC1_5363	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
APLC1_5367	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
APLC1_5368	COG0148	phosphopyruvate hydratase activity
APLC1_5370	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
APLC1_5371	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
APLC1_5374	COG0134	indole-3-glycerol-phosphate synthase activity
APLC1_5377	COG1196	nuclear chromosome segregation
APLC1_5379	COG1196	nuclear chromosome segregation
APLC1_5384	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
APLC1_5387	COG0745	RESPONSE REGULATOR receiver
APLC1_5389	COG5002	protein histidine kinase activity
APLC1_5392	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APLC1_5395	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APLC1_5398	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
APLC1_5406	COG2211	Major facilitator Superfamily
APLC1_5407	COG2211	Major facilitator Superfamily
APLC1_5408	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
APLC1_5409	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APLC1_5409	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
APLC1_5411	COG2226	methyltransferase
APLC1_5416	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
APLC1_5421	COG0484	heat shock protein binding
APLC1_5426	COG0488	(ABC) transporter
APLC1_5427	COG2204	response regulator
APLC1_5428	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
APLC1_5429	COG0254	rRNA binding
APLC1_5430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
APLC1_5431	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
APLC1_5432	COG0101	tRNA pseudouridine synthase activity
APLC1_5433	COG0203	ribosomal protein L17
APLC1_5434	COG0202	RNA polymerase activity
APLC1_5435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
APLC1_5436	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
APLC1_5437	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
APLC1_5438	COG0563	adenylate kinase activity
APLC1_5439	COG0201	protein transport
APLC1_5440	COG0200	Binds to the 23S rRNA
APLC1_5441	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
APLC1_5442	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
APLC1_5443	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
APLC1_5444	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
APLC1_5445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
APLC1_5446	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
APLC1_5447	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
APLC1_5448	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
APLC1_5449	COG0255	Belongs to the universal ribosomal protein uL29 family
APLC1_5450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
APLC1_5451	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
APLC1_5452	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
APLC1_5453	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
APLC1_5454	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
APLC1_5455	COG0089	rRNA binding
APLC1_5456	COG0088	Forms part of the polypeptide exit tunnel
APLC1_5457	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
APLC1_5460	COG5002	protein histidine kinase activity
APLC1_5464	COG2850	peptidyl-arginine hydroxylation
APLC1_5470	COG0463	Glycosyl transferase, family 2
APLC1_5471	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APLC1_5472	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
APLC1_5475	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
APLC1_5476	COG3273	potassium ion transport
APLC1_5476	COG0471	metal ion transport
APLC1_5479	COG0745	RESPONSE REGULATOR receiver
APLC1_5481	COG0138	bifunctional purine biosynthesis protein purh
APLC1_5482	COG0328	RNA-DNA hybrid ribonuclease activity
APLC1_5483	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
APLC1_5485	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
APLC1_5487	COG3118	belongs to the thioredoxin family
APLC1_5489	COG0583	DNA-binding transcription factor activity
APLC1_5490	COG0583	DNA-binding transcription factor activity
APLC1_5491	COG0515	serine threonine protein kinase
APLC1_5492	COG0675	Transposase, IS605 OrfB family
APLC1_5495	COG0667	Aldo Keto reductase
APLC1_5497	COG0307	riboflavin synthase, alpha
APLC1_5498	COG2885	chlorophyll binding
APLC1_5499	COG2885	chlorophyll binding
APLC1_5501	COG0596	Alpha beta hydrolase
APLC1_5503	COG0121	glutamine amidotransferase
APLC1_5507	COG1073	alpha beta
APLC1_5508	COG0509	glycine decarboxylation via glycine cleavage system
APLC1_5509	COG1191	sigma factor activity
APLC1_5513	COG0857	belongs to the CobB CobQ family
APLC1_5516	COG1215	transferase activity, transferring glycosyl groups
APLC1_5517	COG0045	succinate-CoA ligase (ADP-forming) activity
APLC1_5518	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
APLC1_5519	COG0415	Belongs to the DNA photolyase family
APLC1_5545	COG0589	response to stress
APLC1_5545	COG0475	glutathione-regulated potassium exporter activity
APLC1_5546	COG0589	response to stress
APLC1_5546	COG0475	glutathione-regulated potassium exporter activity
APLC1_5547	COG0589	response to stress
APLC1_5547	COG0475	glutathione-regulated potassium exporter activity
APLC1_5551	COG0336	Belongs to the RNA methyltransferase TrmD family
APLC1_5553	COG4242	Belongs to the peptidase S51 family
APLC1_5555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
APLC1_5555	COG0189	ligase activity
APLC1_5558	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APLC1_5559	COG3409	Peptidoglycan-binding domain 1 protein
APLC1_5565	COG1214	PFAM Peptidase M22, glycoprotease
APLC1_5574	COG0515	serine threonine protein kinase
APLC1_5574	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_5576	COG2203	Gaf domain
APLC1_5576	COG3706	GGDEF domain
APLC1_5576	COG5001	Diguanylate cyclase
APLC1_5576	COG4251	negative regulation of phosphorylation
APLC1_5577	COG0617	tRNA 3'-terminal CCA addition
APLC1_5582	COG0784	Response regulator, receiver
APLC1_5585	COG0840	transmembrane signaling receptor activity
APLC1_5586	COG0643	Histidine kinase
APLC1_5586	COG0784	Response regulator, receiver
APLC1_5586	COG2198	Histidine kinase
APLC1_5596	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APLC1_5609	COG4251	negative regulation of phosphorylation
APLC1_5609	COG3706	GGDEF domain
APLC1_5609	COG2203	Gaf domain
APLC1_5609	COG5001	Diguanylate cyclase
APLC1_5611	COG0791	NLP P60 protein
APLC1_5616	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APLC1_5617	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APLC1_5618	COG0424	maF-like protein
APLC1_5624	COG0154	amidase activity
APLC1_5626	COG1127	ABC transporter
APLC1_5627	COG0391	Required for morphogenesis under gluconeogenic growth conditions
APLC1_5630	COG0612	Peptidase, M16
APLC1_5633	COG0848	biopolymer transport protein
APLC1_5634	COG0811	peptide transport
APLC1_5635	COG1492	cobalamin metabolic process
APLC1_5637	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
APLC1_5646	COG0724	RNA recognition motif
APLC1_5649	COG0737	Belongs to the 5'-nucleotidase family
APLC1_5650	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
APLC1_5651	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
APLC1_5652	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APLC1_5654	COG0483	inositol monophosphate 1-phosphatase activity
APLC1_5656	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
APLC1_5660	COG0436	Aminotransferase
APLC1_5661	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APLC1_5661	COG3266	domain, Protein
APLC1_5662	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
APLC1_5670	COG0195	Participates in both transcription termination and antitermination
APLC1_5671	COG0779	Required for maturation of 30S ribosomal subunits
APLC1_5673	COG1216	Glycosyl transferase, family 2
APLC1_5674	COG0360	Binds together with S18 to 16S ribosomal RNA
APLC1_5681	COG1776	CheC inhibitor of MCP methylation
APLC1_5682	COG2201	protein-glutamate methylesterase activity
APLC1_5684	COG0446	pyridine nucleotide-disulphide oxidoreductase
APLC1_5685	COG0579	oxidoreductase
APLC1_5687	COG1108	ABC-type Mn2 Zn2 transport systems permease components
APLC1_5688	COG1121	(ABC) transporter
APLC1_5690	COG0557	exoribonuclease II activity
APLC1_5691	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
APLC1_5692	COG0267	Belongs to the bacterial ribosomal protein bL33 family
APLC1_5700	COG0436	Aminotransferase
APLC1_5701	COG3118	belongs to the thioredoxin family
APLC1_5708	COG1494	fructose-1,6-bisphosphatase
APLC1_5709	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
APLC1_5710	COG0525	valine-tRNA ligase activity
APLC1_5711	COG0525	valine-tRNA ligase activity
APLC1_5712	COG0525	valine-tRNA ligase activity
APLC1_5715	COG1672	PFAM Archaeal ATPase
APLC1_5715	COG2319	Wd-40 repeat
APLC1_5717	COG1672	PFAM Archaeal ATPase
APLC1_5717	COG2319	Wd-40 repeat
APLC1_5718	COG0009	L-threonylcarbamoyladenylate synthase
APLC1_5719	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
APLC1_5720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
APLC1_5721	COG1850	ribulose-bisphosphate carboxylase activity
APLC1_5722	COG0235	Class ii aldolase
APLC1_5723	COG2082	Precorrin-8x methylmutase
APLC1_5725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
APLC1_5730	COG0444	Belongs to the ABC transporter superfamily
APLC1_5731	COG4608	Belongs to the ABC transporter superfamily
APLC1_5734	COG0657	acetylesterase activity
APLC1_5737	COG3001	Fructosamine kinase
APLC1_5738	COG3001	Fructosamine kinase
APLC1_5741	COG2949	membrane
APLC1_5743	COG0157	Belongs to the NadC ModD family
APLC1_5745	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
APLC1_5746	COG1216	Glycosyl transferase, family 2
APLC1_5748	COG1132	(ABC) transporter
APLC1_5749	COG0438	transferase activity, transferring glycosyl groups
APLC1_5752	COG0438	transferase activity, transferring glycosyl groups
APLC1_5753	COG1216	Glycosyl transferase, family 2
APLC1_5756	COG0438	transferase activity, transferring glycosyl groups
APLC1_5757	COG0438	transferase activity, transferring glycosyl groups
APLC1_5758	COG1216	Glycosyl transferase, family 2
APLC1_5764	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
APLC1_5766	COG0515	serine threonine protein kinase
APLC1_5766	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_5768	COG2205	protein histidine kinase activity
APLC1_5768	COG0784	Response regulator, receiver
APLC1_5771	COG3842	ATPase activity
APLC1_5774	COG1653	transport
APLC1_5775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
APLC1_5776	COG2076	Multidrug Resistance protein
APLC1_5779	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_5779	COG0515	serine threonine protein kinase
APLC1_5780	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_5780	COG0515	serine threonine protein kinase
APLC1_5781	COG0784	Response regulator, receiver
APLC1_5781	COG2205	protein histidine kinase activity
APLC1_5784	COG1252	NADH dehydrogenase
APLC1_5786	COG0802	atpase or kinase
APLC1_5788	COG1136	(ABC) transporter
APLC1_5791	COG3850	Histidine kinase
APLC1_5791	COG5002	protein histidine kinase activity
APLC1_5792	COG5000	phosphorelay sensor kinase activity
APLC1_5792	COG5002	protein histidine kinase activity
APLC1_5793	COG0713	ATP synthesis coupled electron transport
APLC1_5794	COG0839	Belongs to the complex I subunit 6 family
APLC1_5795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APLC1_5796	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
APLC1_5797	COG0372	Belongs to the citrate synthase family
APLC1_5798	COG2062	phosphohistidine phosphatase, SixA
APLC1_5800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
APLC1_5802	COG0612	Peptidase, M16
APLC1_5809	COG0135	phosphoribosylanthranilate isomerase activity
APLC1_5812	COG0358	DNA primase activity
APLC1_5814	COG2319	Wd-40 repeat
APLC1_5814	COG4249	Peptidase C14 caspase catalytic subunit p20
APLC1_5820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
APLC1_5823	COG1215	transferase activity, transferring glycosyl groups
APLC1_5829	COG2270	Major facilitator Superfamily
APLC1_5832	COG0635	Involved in the biosynthesis of porphyrin-containing compound
APLC1_5834	COG5001	Diguanylate cyclase
APLC1_5834	COG2203	Gaf domain
APLC1_5834	COG3706	GGDEF domain
APLC1_5834	COG4251	negative regulation of phosphorylation
APLC1_5835	COG5001	Diguanylate cyclase
APLC1_5835	COG3300	MHYT domain
APLC1_5837	COG0745	RESPONSE REGULATOR receiver
APLC1_5841	COG0784	Response regulator, receiver
APLC1_5841	COG2205	protein histidine kinase activity
APLC1_5841	COG5002	protein histidine kinase activity
APLC1_5842	COG0589	response to stress
APLC1_5843	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
APLC1_5844	COG0268	Binds directly to 16S ribosomal RNA
APLC1_5845	COG0084	hydrolase, TatD family'
APLC1_5846	COG0085	RNA polymerase activity
APLC1_5847	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APLC1_5848	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APLC1_5849	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
APLC1_5852	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
APLC1_5865	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
APLC1_5866	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
APLC1_5867	COG0047	phosphoribosylformylglycinamidine synthase activity
APLC1_5873	COG0318	PFAM AMP-dependent synthetase and ligase
APLC1_5874	COG3320	Male sterility
APLC1_5874	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APLC1_5875	COG0156	8-amino-7-oxononanoate synthase activity
APLC1_5876	COG0156	8-amino-7-oxononanoate synthase activity
APLC1_5877	COG1032	radical SAM domain protein
APLC1_5880	COG0419	ATPase involved in DNA repair
APLC1_5882	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
APLC1_5885	COG0129	dihydroxy-acid dehydratase activity
APLC1_5890	COG3659	wide pore channel activity
APLC1_5891	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
APLC1_5901	COG2217	Heavy metal translocating P-type atpase
APLC1_5901	COG2608	mercury ion transmembrane transporter activity
APLC1_5903	COG2217	Heavy metal translocating P-type atpase
APLC1_5904	COG1597	lipid kinase activity
APLC1_5904	COG1803	Methylglyoxal synthase
APLC1_5905	COG1253	flavin adenine dinucleotide binding
APLC1_5951	COG1475	DNA binding
APLC1_5952	COG0842	Transport permease protein
APLC1_5952	COG1131	(ABC) transporter
APLC1_5952	COG1716	ATPase activity
APLC1_5953	COG0515	serine threonine protein kinase
APLC1_5953	COG3266	domain, Protein
APLC1_5955	COG0515	serine threonine protein kinase
APLC1_5958	COG1475	DNA binding
APLC1_5959	COG1475	DNA binding
APLC1_5963	COG0515	serine threonine protein kinase
APLC1_5963	COG0457	Tetratricopeptide repeat
APLC1_5965	COG1674	ftsk spoiiie
APLC1_5971	COG2815	serine threonine protein kinase
APLC1_5971	COG0515	serine threonine protein kinase
APLC1_5973	COG0367	asparagine synthase
APLC1_5976	COG0469	pyruvate kinase activity
APLC1_5982	COG1028	Short-chain dehydrogenase reductase Sdr
APLC1_5983	COG1028	Short-chain dehydrogenase reductase Sdr
APLC1_5990	COG3243	poly(R)-hydroxyalkanoic acid synthase
APLC1_5997	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APLC1_6000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
APLC1_6007	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
APLC1_6007	COG2022	thiamine diphosphate biosynthetic process
APLC1_6009	COG0300	oxidoreductase activity
APLC1_6025	COG3788	relative of glutathione S-transferase, MAPEG superfamily
APLC1_6027	COG4251	negative regulation of phosphorylation
APLC1_6027	COG2203	Gaf domain
APLC1_6027	COG5001	Diguanylate cyclase
APLC1_6027	COG3706	GGDEF domain
APLC1_6028	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
APLC1_6032	COG0083	homoserine kinase activity
APLC1_6037	COG0515	serine threonine protein kinase
APLC1_6037	COG1357	PFAM Pentapeptide repeats (8 copies)
APLC1_6045	COG0166	Belongs to the GPI family
APLC1_6046	COG0857	belongs to the CobB CobQ family
APLC1_6046	COG0280	phosphate acetyltransferase
APLC1_6049	COG3300	MHYT domain
APLC1_6049	COG5001	Diguanylate cyclase
APLC1_6051	COG1733	regulation of RNA biosynthetic process
APLC1_6052	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
APLC1_6052	COG0574	Belongs to the PEP-utilizing enzyme family
APLC1_6056	COG4178	(ABC) transporter
APLC1_6057	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
APLC1_6059	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
APLC1_6062	COG4191	Histidine kinase
APLC1_6062	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APLC1_6063	COG1028	Short-chain dehydrogenase reductase Sdr
APLC1_6078	COG0237	dephospho-CoA kinase activity
APLC1_6079	COG5398	heme oxygenase
APLC1_6080	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
APLC1_6082	COG3852	Histidine kinase
APLC1_6086	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
APLC1_6088	COG0022	dehydrogenase e1 component
APLC1_6088	COG0508	dehydrogenase complex catalyzes the overall conversion of
APLC1_6089	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APLC1_6090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
APLC1_6095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
APLC1_6102	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
APLC1_6103	COG2189	Belongs to the N(4) N(6)-methyltransferase family
APLC1_6108	COG1573	uracil-dna glycosylase
APLC1_6113	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
APLC1_6115	COG0484	heat shock protein binding
APLC1_6117	COG0456	acetyltransferase
APLC1_6119	COG0746	molybdenum cofactor guanylyltransferase activity
APLC1_6130	COG1505	serine-type exopeptidase activity
APLC1_6131	COG1505	serine-type exopeptidase activity
APLC1_6133	COG0514	ATP-dependent DNA helicase (RecQ)
APLC1_6135	COG0584	glycerophosphoryl diester phosphodiesterase
APLC1_6140	COG3842	ATPase activity
APLC1_6142	COG0719	Fe-S assembly protein
APLC1_6142	COG1372	Participates in initiation and elongation during chromosome replication
APLC1_6143	COG0756	dUTP diphosphatase activity
APLC1_6144	COG2131	deaminase
APLC1_6145	COG2304	oxidoreductase activity
APLC1_6152	COG0404	The glycine cleavage system catalyzes the degradation of glycine
APLC1_6153	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
APLC1_6157	COG2181	nitrate reductase activity
APLC1_6159	COG1140	nitrate reductase beta subunit
APLC1_6160	COG1140	nitrate reductase beta subunit
APLC1_6161	COG2346	COG2346, Truncated hemoglobins
APLC1_6166	COG4636	protein conserved in cyanobacteria
APLC1_6173	COG4636	protein conserved in cyanobacteria
APLC1_6191	COG0571	ribonuclease III activity
APLC1_6193	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
APLC1_6194	COG1672	PFAM Archaeal ATPase
APLC1_6198	COG0343	queuine tRNA-ribosyltransferase activity
APLC1_6200	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
APLC1_6205	COG0667	Aldo Keto reductase
APLC1_6211	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
APLC1_6220	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
APLC1_6221	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
APLC1_6223	COG3185	4-Hydroxyphenylpyruvate dioxygenase
APLC1_6226	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APLC1_6229	COG0706	membrane insertase activity
APLC1_6231	COG0594	ribonuclease P activity
APLC1_6232	COG0230	Belongs to the bacterial ribosomal protein bL34 family
APLC1_6239	COG1192	Involved in chromosome partitioning
APLC1_6240	COG0482	sulfurtransferase activity
APLC1_6242	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
APLC1_6245	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APLC1_6249	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
APLC1_6251	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
APLC1_6253	COG0827	DNA restriction-modification system
APLC1_6254	COG0827	DNA restriction-modification system
APLC1_6257	COG0745	RESPONSE REGULATOR receiver
APLC1_6258	COG2205	protein histidine kinase activity
APLC1_6258	COG0784	Response regulator, receiver
APLC1_6259	COG0628	permease
APLC1_6264	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
APLC1_6267	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
APLC1_6268	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APLC1_6269	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
APLC1_6270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
APLC1_6271	COG2048	Heterodisulfide reductase, subunit B
APLC1_6272	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
APLC1_6273	COG1943	Transposase
APLC1_6275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
APLC1_6281	COG0277	FAD linked oxidase domain protein
APLC1_6282	COG0247	lactate metabolic process
APLC1_6283	COG5002	protein histidine kinase activity
APLC1_6283	COG0784	Response regulator, receiver
APLC1_6283	COG2205	protein histidine kinase activity
APLC1_6284	COG0432	Pfam Uncharacterised protein family UPF0047
APLC1_6287	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
APLC1_6288	COG0312	modulator of DNA gyrase
APLC1_6289	COG0312	modulator of DNA gyrase
APLC1_6293	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
APLC1_6297	COG2815	serine threonine protein kinase
APLC1_6297	COG0515	serine threonine protein kinase
APLC1_6298	COG3852	Histidine kinase
APLC1_6300	COG1649	PFAM Uncharacterised BCR, COG1649
APLC1_6301	COG1696	Membrane protein involved in D-alanine export
APLC1_6302	COG0481	GTPase activity
APLC1_6304	COG0681	Belongs to the peptidase S26 family
APLC1_6310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
APLC1_6311	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
APLC1_6312	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
APLC1_6344	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APLC1_6344	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APLC1_6345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APLC1_6345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
APLC1_6348	COG0745	RESPONSE REGULATOR receiver
APLC1_6353	COG0783	Belongs to the Dps family
APLC1_6354	COG0539	negative regulation of cytoplasmic translation
APLC1_6356	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
APLC1_6357	COG2022	thiamine diphosphate biosynthetic process
APLC1_6360	COG0745	RESPONSE REGULATOR receiver
APLC1_6362	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
APLC1_6365	COG1193	negative regulation of DNA recombination
APLC1_6372	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
APLC1_6372	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
APLC1_6373	COG3903	Transcriptional regulator
APLC1_6373	COG2319	Wd-40 repeat
APLC1_6380	COG0675	Transposase, IS605 OrfB family
APLC1_6396	COG1222	aaa ATPase
APLC1_6399	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
APLC1_6408	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
APLC1_6410	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
APLC1_6412	COG0731	radical SAM domain protein
APLC1_6418	COG0003	Pfam Anion-transporting ATPase
APLC1_6423	COG0675	Transposase, IS605 OrfB family
APLC1_6438	COG1132	(ABC) transporter
APLC1_6440	COG0019	diaminopimelate decarboxylase activity
APLC1_6441	COG0019	diaminopimelate decarboxylase activity
APLC1_6450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
APLC1_6451	COG0066	3-isopropylmalate dehydratase activity
APLC1_6452	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
APLC1_6458	COG0546	phosphoglycolate phosphatase activity
APLC1_6459	COG4279	zinc finger
APLC1_6463	COG1598	PFAM Uncharacterised protein family UPF0150
APLC1_6511	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
APLC1_6512	COG0451	ADP-glyceromanno-heptose 6-epimerase activity