locus-tag	class	description
EKO05_0000008	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0000029	COG2267	carboxylic ester hydrolase activity
EKO05_0000031	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EKO05_0000057	COG3507	Belongs to the glycosyl hydrolase 43 family
EKO05_0000070	COG2124	cytochrome p450
EKO05_0000070	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EKO05_0000093	COG1454	alcohol dehydrogenase
EKO05_0000098	COG1028	Short-chain dehydrogenase reductase Sdr
EKO05_0000129	COG0384	phenazine biosynthesis protein PhzF
EKO05_0000140	COG2814	Major facilitator Superfamily
EKO05_0000178	COG0009	L-threonylcarbamoyladenylate synthase
EKO05_0000234	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EKO05_0000250	COG2124	cytochrome p450
EKO05_0000263	COG0515	serine threonine protein kinase
EKO05_0000273	COG2226	methyltransferase
EKO05_0000280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EKO05_0000311	COG1250	3-hydroxyacyl-CoA dehydrogenase
EKO05_0000393	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EKO05_0000487	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EKO05_0000530	COG1660	Displays ATPase and GTPase activities
EKO05_0000542	COG0142	geranyltranstransferase activity
EKO05_0000549	COG1643	Atp-dependent helicase
EKO05_0000659	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EKO05_0000673	COG2814	Major facilitator Superfamily
EKO05_0000820	COG1741	Belongs to the pirin family
EKO05_0000833	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EKO05_0000847	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EKO05_0000856	COG0494	nUDIX hydrolase
EKO05_0000909	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EKO05_0000920	COG0058	SHG alpha-glucan phosphorylase activity
EKO05_0000926	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EKO05_0000949	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EKO05_0000973	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EKO05_0000996	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0001008	COG0514	ATP-dependent DNA helicase (RecQ)
EKO05_0001019	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EKO05_0001094	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
EKO05_0001163	COG2070	2-Nitropropane dioxygenase
EKO05_0001186	COG1335	isochorismatase
EKO05_0001214	COG4221	oxidoreductase activity
EKO05_0001241	COG2365	Tyrosine phosphatase family
EKO05_0001267	COG1250	3-hydroxyacyl-CoA dehydrogenase
EKO05_0001268	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EKO05_0001335	COG1902	pentaerythritol trinitrate reductase activity
EKO05_0001380	COG3844	kynureninase activity
EKO05_0001406	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EKO05_0001423	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0001475	COG0513	Belongs to the DEAD box helicase family
EKO05_0001481	COG0542	response to heat
EKO05_0001605	COG0167	dihydroorotate dehydrogenase activity
EKO05_0001619	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EKO05_0001726	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EKO05_0001835	COG1064	alcohol dehydrogenase
EKO05_0001896	COG4106	trans-aconitate 2-methyltransferase activity
EKO05_0001967	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EKO05_0001986	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EKO05_0002038	COG1064	alcohol dehydrogenase
EKO05_0002097	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EKO05_0002097	COG2169	Transcriptional regulator
EKO05_0002118	COG0662	Cupin 2, conserved barrel domain protein
EKO05_0002143	COG2217	Heavy metal translocating P-type atpase
EKO05_0002150	COG0017	Asparaginyl-tRNA synthetase
EKO05_0002214	COG3064	Membrane
EKO05_0002214	COG4991	sh3 domain protein
EKO05_0002214	COG0515	serine threonine protein kinase
EKO05_0002260	COG1643	Atp-dependent helicase
EKO05_0002289	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EKO05_0002437	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0002501	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EKO05_0002503	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EKO05_0002509	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0002519	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EKO05_0002519	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EKO05_0002520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EKO05_0002523	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0002536	COG0626	cystathionine gamma-synthase activity
EKO05_0002569	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EKO05_0002585	COG1028	Short-chain dehydrogenase reductase Sdr
EKO05_0002611	COG1335	isochorismatase
EKO05_0002619	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EKO05_0002701	COG0671	phosphoesterase, PA-phosphatase related
EKO05_0002701	COG2453	phosphatase
EKO05_0002779	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EKO05_0002813	COG0830	nickel cation binding
EKO05_0002837	COG0154	amidase activity
EKO05_0002858	COG2815	serine threonine protein kinase
EKO05_0002858	COG0515	serine threonine protein kinase
EKO05_0002905	COG0436	Aminotransferase
EKO05_0002922	COG0131	Imidazoleglycerol-phosphate dehydratase
EKO05_0002928	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EKO05_0003008	COG2205	protein histidine kinase activity
EKO05_0003008	COG0784	Response regulator, receiver
EKO05_0003008	COG5002	protein histidine kinase activity
EKO05_0003056	COG0193	aminoacyl-tRNA hydrolase activity
EKO05_0003087	COG1501	Belongs to the glycosyl hydrolase 31 family
EKO05_0003133	COG0571	ribonuclease III activity
EKO05_0003148	COG0151	Belongs to the GarS family
EKO05_0003159	COG4702	Belongs to the UPF0303 family
EKO05_0003187	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EKO05_0003202	COG0514	ATP-dependent DNA helicase (RecQ)
EKO05_0003222	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0003329	COG3830	Belongs to the UPF0237 family
EKO05_0003329	COG0560	Phosphoserine phosphatase
EKO05_0003373	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EKO05_0003416	COG0484	heat shock protein binding
EKO05_0003439	COG3867	Arabinogalactan endo-beta-1,4-galactanase
EKO05_0003460	COG0724	RNA recognition motif
EKO05_0003462	COG1028	Short-chain dehydrogenase reductase Sdr
EKO05_0003492	COG2895	sulfate adenylyltransferase (ATP) activity
EKO05_0003495	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
EKO05_0003561	COG0513	Belongs to the DEAD box helicase family
EKO05_0003593	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0003662	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EKO05_0003663	COG0673	inositol 2-dehydrogenase activity
EKO05_0003664	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EKO05_0003670	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EKO05_0003678	COG0515	serine threonine protein kinase
EKO05_0003728	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EKO05_0003733	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EKO05_0003757	COG4221	oxidoreductase activity
EKO05_0003759	COG2130	NADP-dependent
EKO05_0003764	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EKO05_0003793	COG2217	Heavy metal translocating P-type atpase
EKO05_0003794	COG0833	amino acid
EKO05_0003827	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EKO05_0003953	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EKO05_0003976	COG2815	serine threonine protein kinase
EKO05_0003976	COG0515	serine threonine protein kinase
EKO05_0003992	COG0179	Fumarylacetoacetate (FAA) hydrolase
EKO05_0004001	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EKO05_0004026	COG0109	protoheme IX farnesyltransferase activity
EKO05_0004031	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EKO05_0004033	COG2272	Belongs to the type-B carboxylesterase lipase family
EKO05_0004050	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EKO05_0004073	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EKO05_0004099	COG0314	molybdopterin synthase activity
EKO05_0004144	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EKO05_0004157	COG0657	acetylesterase activity
EKO05_0004176	COG0321	lipoyl(octanoyl) transferase activity
EKO05_0004261	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EKO05_0004283	COG0110	maltose O-acetyltransferase activity
EKO05_0004290	COG2272	Belongs to the type-B carboxylesterase lipase family
EKO05_0004308	COG1028	Short-chain dehydrogenase reductase Sdr
EKO05_0004312	COG2897	thiosulfate sulfurtransferase activity
EKO05_0004314	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EKO05_0004315	COG0326	Molecular chaperone. Has ATPase activity
EKO05_0004334	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EKO05_0004339	COG0457	Tetratricopeptide repeat
EKO05_0004339	COG0515	serine threonine protein kinase
EKO05_0004359	COG0833	amino acid
EKO05_0004360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EKO05_0004378	COG0625	glutathione transferase activity
EKO05_0004483	COG3507	Belongs to the glycosyl hydrolase 43 family
EKO05_0004579	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EKO05_0004590	COG0514	ATP-dependent DNA helicase (RecQ)
EKO05_0004598	COG1404	Belongs to the peptidase S8 family
EKO05_0004650	COG3321	synthase
EKO05_0004650	COG0604	alcohol dehydrogenase
EKO05_0004686	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EKO05_0004717	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0004736	COG2706	6-phosphogluconolactonase activity
EKO05_0004762	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EKO05_0004773	COG2814	Major facilitator Superfamily
EKO05_0004854	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EKO05_0004869	COG0515	serine threonine protein kinase
EKO05_0004884	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EKO05_0004885	COG1902	pentaerythritol trinitrate reductase activity
EKO05_0004891	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EKO05_0005000	COG0656	L-ascorbic acid biosynthetic process
EKO05_0005001	COG0316	Belongs to the HesB IscA family
EKO05_0005004	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EKO05_0005007	COG0657	acetylesterase activity
EKO05_0005033	COG1054	Belongs to the UPF0176 family
EKO05_0005043	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
EKO05_0005079	COG4702	Belongs to the UPF0303 family
EKO05_0005088	COG0656	L-ascorbic acid biosynthetic process
EKO05_0005103	COG5265	(ABC) transporter
EKO05_0005191	COG0514	ATP-dependent DNA helicase (RecQ)
EKO05_0005195	COG0514	ATP-dependent DNA helicase (RecQ)
EKO05_0005234	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EKO05_0005236	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EKO05_0005285	COG0829	nickel cation binding
EKO05_0005311	COG0156	8-amino-7-oxononanoate synthase activity
EKO05_0005376	COG0604	alcohol dehydrogenase
EKO05_0005413	COG0484	heat shock protein binding
EKO05_0005438	COG0667	Aldo Keto reductase
EKO05_0005439	COG1064	alcohol dehydrogenase
EKO05_0005517	COG1024	Enoyl-CoA hydratase
EKO05_0005550	COG3781	membrane
EKO05_0005602	COG2217	Heavy metal translocating P-type atpase
EKO05_0005612	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EKO05_0005625	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EKO05_0005643	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EKO05_0005679	COG2267	carboxylic ester hydrolase activity
EKO05_0005692	COG0277	FAD linked oxidase domain protein
EKO05_0005726	COG1304	FMN binding
EKO05_0005775	COG2272	Belongs to the type-B carboxylesterase lipase family
EKO05_0005784	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EKO05_0005833	COG0235	Class ii aldolase
EKO05_0005855	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EKO05_0005959	COG1028	Short-chain dehydrogenase reductase Sdr
EKO05_0005964	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EKO05_0006011	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EKO05_0006014	COG0483	inositol monophosphate 1-phosphatase activity
EKO05_0006033	COG1902	pentaerythritol trinitrate reductase activity
EKO05_0006034	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
EKO05_0006050	COG0596	Alpha beta hydrolase
EKO05_0006066	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EKO05_0006066	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EKO05_0006084	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EKO05_0006092	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EKO05_0006105	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EKO05_0006105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EKO05_0006137	COG0514	ATP-dependent DNA helicase (RecQ)
EKO05_0006213	COG2828	Protein conserved in bacteria
EKO05_0006393	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EKO05_0006496	COG4122	O-methyltransferase activity
EKO05_0006525	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EKO05_0006526	COG0436	Aminotransferase
EKO05_0006547	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EKO05_0006594	COG1012	belongs to the aldehyde dehydrogenase family
EKO05_0006654	COG1028	Short-chain dehydrogenase reductase Sdr
EKO05_0006690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EKO05_0006702	COG3693	PFAM glycoside hydrolase, family 10
EKO05_0006742	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EKO05_0006763	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
EKO05_0006771	COG3938	Belongs to the proline racemase family
EKO05_0006806	COG2814	Major facilitator Superfamily
EKO05_0006823	COG0154	amidase activity
EKO05_0006855	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EKO05_0006912	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EKO05_0006913	COG0534	Mate efflux family protein
EKO05_0006932	COG1028	Short-chain dehydrogenase reductase Sdr
EKO05_0006991	COG3791	Glutathione-dependent formaldehyde-activating
EKO05_0007030	COG0542	response to heat
EKO05_0007059	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EKO05_0007074	COG0277	FAD linked oxidase domain protein
EKO05_0007107	COG1335	isochorismatase
EKO05_0007185	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0007211	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EKO05_0007231	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EKO05_0007269	COG3459	Glycosyltransferase 36 associated
EKO05_0007400	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EKO05_0007457	COG0572	uridine kinase
EKO05_0007499	COG0066	3-isopropylmalate dehydratase activity
EKO05_0007502	COG0440	acetolactate synthase activity
EKO05_0007524	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EKO05_0007537	COG2815	serine threonine protein kinase
EKO05_0007537	COG0515	serine threonine protein kinase
EKO05_0007577	COG0738	Major facilitator superfamily
EKO05_0007663	COG3525	Glycosyl hydrolase, family 20, catalytic domain
EKO05_0007708	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EKO05_0007726	COG0673	inositol 2-dehydrogenase activity
EKO05_0007775	COG0154	amidase activity
EKO05_0007846	COG1793	dna ligase
EKO05_0007870	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EKO05_0007881	COG0584	glycerophosphoryl diester phosphodiesterase
EKO05_0007914	COG1028	Short-chain dehydrogenase reductase Sdr
EKO05_0007937	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EKO05_0007949	COG1063	alcohol dehydrogenase
EKO05_0007952	COG0604	alcohol dehydrogenase
EKO05_0007952	COG1028	Short-chain dehydrogenase reductase Sdr
EKO05_0007952	COG3321	synthase
EKO05_0007958	COG0514	ATP-dependent DNA helicase (RecQ)
EKO05_0007971	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0007972	COG0513	Belongs to the DEAD box helicase family
EKO05_0008024	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EKO05_0008038	COG0071	Belongs to the small heat shock protein (HSP20) family
EKO05_0008111	COG0477	Major facilitator Superfamily
EKO05_0008118	COG2217	Heavy metal translocating P-type atpase
EKO05_0008165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EKO05_0008210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EKO05_0008226	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EKO05_0008281	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EKO05_0008282	COG0833	amino acid
EKO05_0008286	COG2070	2-Nitropropane dioxygenase
EKO05_0008320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EKO05_0008401	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EKO05_0008464	COG0514	ATP-dependent DNA helicase (RecQ)
EKO05_0008485	COG0515	serine threonine protein kinase
EKO05_0008485	COG2815	serine threonine protein kinase
EKO05_0008504	COG0833	amino acid
EKO05_0008535	COG1418	mRNA catabolic process
EKO05_0008592	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EKO05_0008640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EKO05_0008658	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EKO05_0008660	COG0531	amino acid
EKO05_0008725	COG0515	serine threonine protein kinase
EKO05_0008725	COG2815	serine threonine protein kinase
EKO05_0008821	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EKO05_0008835	COG1418	mRNA catabolic process
EKO05_0008837	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EKO05_0008858	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EKO05_0008858	COG0512	Glutamine amidotransferase of anthranilate synthase
EKO05_0008859	COG1331	Highly conserved protein containing a thioredoxin domain
EKO05_0008864	COG1643	Atp-dependent helicase
EKO05_0008902	COG0514	ATP-dependent DNA helicase (RecQ)
EKO05_0008996	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EKO05_0008996	COG0519	Catalyzes the synthesis of GMP from XMP
EKO05_0009040	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EKO05_0009086	COG1252	NADH dehydrogenase
EKO05_0009169	COG0513	Belongs to the DEAD box helicase family
EKO05_0009170	COG3693	PFAM glycoside hydrolase, family 10
EKO05_0009173	COG0259	pyridoxamine-phosphate oxidase activity
EKO05_0009177	COG0252	asparaginase activity
EKO05_0009186	COG2175	clavaminate synthase activity
EKO05_0009309	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EKO05_0009326	COG1643	Atp-dependent helicase
EKO05_0009360	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EKO05_0009378	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EKO05_0009393	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EKO05_0009406	COG0514	ATP-dependent DNA helicase (RecQ)
EKO05_0009433	COG0017	Asparaginyl-tRNA synthetase
EKO05_0009510	COG4106	trans-aconitate 2-methyltransferase activity
EKO05_0009519	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EKO05_0009566	COG2040	homocysteine
EKO05_0009580	COG1793	dna ligase
EKO05_0009629	COG0515	serine threonine protein kinase
EKO05_0009663	COG2272	Belongs to the type-B carboxylesterase lipase family
EKO05_0009672	COG0657	acetylesterase activity
EKO05_0009705	COG0484	heat shock protein binding
EKO05_0009712	COG0515	serine threonine protein kinase
EKO05_0009873	COG0237	dephospho-CoA kinase activity
EKO05_0009878	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EKO05_0009913	COG0625	glutathione transferase activity
EKO05_0009937	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0010030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EKO05_0010052	COG0489	protein tyrosine kinase activity
EKO05_0010065	COG3250	beta-galactosidase activity
EKO05_0010086	COG0047	phosphoribosylformylglycinamidine synthase activity
EKO05_0010086	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EKO05_0010098	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0010118	COG3509	depolymerase
EKO05_0010176	COG0477	Major facilitator Superfamily
EKO05_0010180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EKO05_0010258	COG1404	Belongs to the peptidase S8 family
EKO05_0010271	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EKO05_0010333	COG1228	amidohydrolase
EKO05_0010381	COG0101	tRNA pseudouridine synthase activity
EKO05_0010388	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EKO05_0010388	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EKO05_0010519	COG0514	ATP-dependent DNA helicase (RecQ)
EKO05_0010532	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0010619	COG5265	(ABC) transporter
EKO05_0010625	COG1612	heme a metabolic process
EKO05_0010634	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EKO05_0010643	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EKO05_0010685	COG0513	Belongs to the DEAD box helicase family
EKO05_0010686	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EKO05_0010687	COG1053	succinate dehydrogenase
EKO05_0010754	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EKO05_0010766	COG0484	heat shock protein binding
EKO05_0010798	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EKO05_0010850	COG0514	ATP-dependent DNA helicase (RecQ)
EKO05_0010878	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
EKO05_0010895	COG0123	including yeast histone deacetylase and acetoin utilization protein
EKO05_0010909	COG2234	aminopeptidase activity
EKO05_0010961	COG1111	helicase
EKO05_0010961	COG1205	dead DEAH box helicase
EKO05_0010970	COG3507	Belongs to the glycosyl hydrolase 43 family
EKO05_0010975	COG0167	dihydroorotate dehydrogenase activity
EKO05_0010976	COG1454	alcohol dehydrogenase
EKO05_0010989	COG0515	serine threonine protein kinase
EKO05_0010989	COG2815	serine threonine protein kinase
EKO05_0010993	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EKO05_0011003	COG0698	ribose 5-phosphate isomerase
EKO05_0011087	COG1335	isochorismatase
EKO05_0011103	COG0149	triose-phosphate isomerase activity
EKO05_0011106	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EKO05_0011156	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EKO05_0011189	COG0246	Mannitol dehydrogenase
EKO05_0011213	COG0514	ATP-dependent DNA helicase (RecQ)
EKO05_0011216	COG0514	ATP-dependent DNA helicase (RecQ)
EKO05_0011277	COG0464	growth
EKO05_0011301	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EKO05_0011335	COG3268	Saccharopine dehydrogenase
EKO05_0011343	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EKO05_0011457	COG2130	NADP-dependent
EKO05_0011481	COG0154	amidase activity
EKO05_0011515	COG2272	Belongs to the type-B carboxylesterase lipase family
EKO05_0011532	COG2272	Belongs to the type-B carboxylesterase lipase family