locus-tag	class	description
AYWB_001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AYWB_003	COG0360	Binds together with S18 to 16S ribosomal RNA
AYWB_004	COG0629	single-stranded DNA binding
AYWB_005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AYWB_006	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AYWB_006	COG0359	binds to the 23S rRNA
AYWB_007	COG0305	Participates in initiation and elongation during chromosome replication
AYWB_008	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AYWB_011	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AYWB_012	COG0525	valine-tRNA ligase activity
AYWB_013	COG4720	Psort location CytoplasmicMembrane, score
AYWB_014	COG1122	ATPase activity
AYWB_016	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYWB_017	COG0071	Belongs to the small heat shock protein (HSP20) family
AYWB_018	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AYWB_019	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYWB_025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYWB_026	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYWB_027	COG1970	mechanosensitive ion channel activity
AYWB_043	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AYWB_048	COG0358	DNA primase activity
AYWB_051	COG0281	malic enzyme
AYWB_052	COG3493	citrate carrier protein
AYWB_053	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AYWB_059	COG1420	regulation of RNA biosynthetic process
AYWB_060	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AYWB_061	COG0443	Heat shock 70 kDa protein
AYWB_062	COG0484	heat shock protein binding
AYWB_064	COG0552	protein localization to endoplasmic reticulum
AYWB_065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AYWB_066	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AYWB_066	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AYWB_067	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AYWB_074	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AYWB_085	COG1074	ATP-dependent DNA helicase activity
AYWB_087	COG0358	DNA primase activity
AYWB_090	COG1461	Dihydroxyacetone kinase
AYWB_093	COG1177	transmembrane transport
AYWB_094	COG1176	ABC-type spermidine putrescine transport system, permease component I
AYWB_095	COG3839	Belongs to the ABC transporter superfamily
AYWB_098	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AYWB_101	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AYWB_103	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AYWB_104	COG0537	adenosine 5'-monophosphoramidase activity
AYWB_110	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AYWB_111	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AYWB_112	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AYWB_115	COG0210	DNA helicase
AYWB_117	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AYWB_120	COG1183	phosphatidylcholine synthase activity
AYWB_121	COG0688	phosphatidylethanolamine metabolic process
AYWB_122	COG0504	CTP synthase activity
AYWB_125	COG0765	amino acid transport
AYWB_128	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AYWB_129	COG0587	DNA-directed DNA polymerase activity
AYWB_130	COG0367	asparagine synthase
AYWB_133	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AYWB_134	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYWB_134	COG0072	phenylalanine-tRNA ligase activity
AYWB_135	COG1136	(ABC) transporter
AYWB_140	COG0084	hydrolase, TatD family'
AYWB_142	COG0416	fatty acid biosynthetic process
AYWB_143	COG0571	ribonuclease III activity
AYWB_175	COG2801	Transposase and inactivated derivatives
AYWB_178	COG0358	DNA primase activity
AYWB_181	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AYWB_187	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYWB_210	COG0776	regulation of translation
AYWB_213	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYWB_219	COG0358	DNA primase activity
AYWB_230	COG0776	regulation of translation
AYWB_241	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AYWB_242	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AYWB_243	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AYWB_244	COG1307	EDD domain protein, DegV family
AYWB_246	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AYWB_249	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AYWB_250	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AYWB_251	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AYWB_252	COG1214	PFAM Peptidase M22, glycoprotease
AYWB_254	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AYWB_255	COG0187	DNA topoisomerase II activity
AYWB_262	COG0765	amino acid transport
AYWB_263	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYWB_264	COG1126	abc transporter atp-binding protein
AYWB_282	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AYWB_285	COG0358	DNA primase activity
AYWB_287	COG2801	Transposase and inactivated derivatives
AYWB_288	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AYWB_289	COG2801	Transposase and inactivated derivatives
AYWB_298	COG2801	Transposase and inactivated derivatives
AYWB_302	COG1051	belongs to the nudix hydrolase family
AYWB_304	COG0653	protein targeting
AYWB_305	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AYWB_306	COG0228	four-way junction DNA binding
AYWB_307	COG0336	Belongs to the RNA methyltransferase TrmD family
AYWB_308	COG0335	large ribosomal subunit rRNA binding
AYWB_309	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AYWB_310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AYWB_311	COG0822	iron-sulfur transferase activity
AYWB_312	COG0180	Tryptophanyl-tRNA synthetase
AYWB_313	COG2176	DNA-directed DNA polymerase activity
AYWB_314	COG0765	amino acid transport
AYWB_316	COG0018	arginyl-trna synthetase
AYWB_317	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AYWB_318	COG0513	Belongs to the DEAD box helicase family
AYWB_320	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AYWB_321	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AYWB_322	COG1481	regulation of sporulation
AYWB_323	COG0736	holo-[acyl-carrier-protein] synthase activity
AYWB_324	COG0446	pyridine nucleotide-disulphide oxidoreductase
AYWB_326	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AYWB_330	COG0481	GTPase activity
AYWB_331	COG0312	modulator of DNA gyrase
AYWB_333	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AYWB_334	COG0544	peptidyl-prolyl cis-trans isomerase activity
AYWB_350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYWB_360	COG2801	Transposase and inactivated derivatives
AYWB_365	COG2801	Transposase and inactivated derivatives
AYWB_375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AYWB_379	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AYWB_398	COG0322	excinuclease ABC activity
AYWB_399	COG0556	nucleotide-excision repair
AYWB_409	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYWB_412	COG0095	Lipoate-protein ligase
AYWB_414	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYWB_415	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AYWB_416	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AYWB_418	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AYWB_420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AYWB_424	COG0742	ribosomal rna small subunit methyltransferase
AYWB_425	COG3763	UPF0154 protein
AYWB_429	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AYWB_430	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AYWB_431	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AYWB_434	COG0469	pyruvate kinase activity
AYWB_436	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AYWB_437	COG0148	phosphopyruvate hydratase activity
AYWB_438	COG0166	Belongs to the GPI family
AYWB_442	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AYWB_445	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AYWB_446	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AYWB_447	COG1692	metallophosphoesterase
AYWB_448	COG1418	mRNA catabolic process
AYWB_453	COG0445	tRNA wobble uridine modification
AYWB_454	COG0357	Ribosomal RNA small subunit methyltransferase G
AYWB_456	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AYWB_457	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AYWB_458	COG0049	tRNA binding
AYWB_459	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AYWB_460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AYWB_461	COG0085	RNA polymerase activity
AYWB_462	COG0222	ribosome binding
AYWB_463	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AYWB_464	COG0081	regulation of translation
AYWB_465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AYWB_466	COG0250	Participates in transcription elongation, termination and antitermination
AYWB_468	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYWB_469	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AYWB_470	COG1185	polyribonucleotide nucleotidyltransferase activity
AYWB_472	COG0706	membrane insertase activity
AYWB_473	COG0594	ribonuclease P activity
AYWB_474	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AYWB_475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AYWB_476	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AYWB_479	COG0776	regulation of translation
AYWB_480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AYWB_481	COG1160	GTP binding
AYWB_482	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AYWB_483	COG1187	pseudouridine synthase activity
AYWB_484	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AYWB_487	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYWB_489	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYWB_489	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYWB_490	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AYWB_491	COG0470	DNA polymerase III
AYWB_492	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AYWB_493	COG0101	tRNA pseudouridine synthase activity
AYWB_494	COG0203	ribosomal protein L17
AYWB_495	COG0202	RNA polymerase activity
AYWB_496	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AYWB_497	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AYWB_498	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AYWB_499	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AYWB_500	COG0024	Methionine aminopeptidase
AYWB_501	COG0563	adenylate kinase activity
AYWB_502	COG0201	protein transport
AYWB_503	COG0200	Binds to the 23S rRNA
AYWB_504	COG1841	ribosomal large subunit assembly
AYWB_505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AYWB_506	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AYWB_507	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AYWB_508	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AYWB_509	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AYWB_510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AYWB_511	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AYWB_512	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AYWB_513	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AYWB_514	COG0255	Belongs to the universal ribosomal protein uL29 family
AYWB_515	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AYWB_516	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AYWB_517	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AYWB_518	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AYWB_519	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AYWB_520	COG0089	rRNA binding
AYWB_521	COG0088	Forms part of the polypeptide exit tunnel
AYWB_522	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AYWB_524	COG0051	transcription antitermination factor activity, RNA binding
AYWB_525	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AYWB_527	COG4608	Belongs to the ABC transporter superfamily
AYWB_528	COG0444	Belongs to the ABC transporter superfamily
AYWB_532	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AYWB_535	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AYWB_536	COG0012	GTP binding
AYWB_537	COG1162	GTPase activity
AYWB_538	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AYWB_540	COG1122	ATPase activity
AYWB_541	COG1122	ATPase activity
AYWB_546	COG0126	phosphoglycerate kinase activity
AYWB_549	COG0149	triose-phosphate isomerase activity
AYWB_551	COG0233	cytoplasmic translational termination
AYWB_552	COG0528	UMP kinase activity
AYWB_553	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AYWB_554	COG0052	Belongs to the universal ribosomal protein uS2 family
AYWB_555	COG0756	dUTP diphosphatase activity
AYWB_560	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AYWB_561	COG1272	protein, Hemolysin III
AYWB_565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AYWB_566	COG1253	flavin adenine dinucleotide binding
AYWB_567	COG0193	aminoacyl-tRNA hydrolase activity
AYWB_569	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AYWB_570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AYWB_572	COG0195	Participates in both transcription termination and antitermination
AYWB_574	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AYWB_576	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYWB_577	COG0301	tRNA thio-modification
AYWB_579	COG0215	cysteine-tRNA ligase activity
AYWB_580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYWB_581	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AYWB_582	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AYWB_585	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AYWB_586	COG3870	Protein conserved in bacteria
AYWB_589	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AYWB_590	COG0564	pseudouridine synthase activity
AYWB_591	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYWB_592	COG0037	tRNA processing
AYWB_593	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AYWB_594	COG0124	histidyl-tRNA synthetase
AYWB_596	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYWB_597	COG0482	sulfurtransferase activity
AYWB_600	COG0459	protein refolding
AYWB_601	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AYWB_603	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AYWB_604	COG0254	rRNA binding
AYWB_605	COG1435	thymidine kinase activity
AYWB_606	COG0590	tRNA wobble adenosine to inosine editing
AYWB_607	COG0617	tRNA 3'-terminal CCA addition
AYWB_608	COG3481	metal-dependent phosphohydrolase, HD sub domain
AYWB_616	COG0358	DNA primase activity
AYWB_619	COG0577	efflux transmembrane transporter activity
AYWB_619	COG1136	(ABC) transporter
AYWB_621	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AYWB_622	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AYWB_622	COG1321	iron dependent repressor
AYWB_623	COG1121	(ABC) transporter
AYWB_624	COG0803	Belongs to the bacterial solute-binding protein 9 family
AYWB_626	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AYWB_627	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AYWB_629	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AYWB_632	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AYWB_633	COG0268	Binds directly to 16S ribosomal RNA
AYWB_635	COG0765	amino acid transport
AYWB_646	COG4869	propanediol catabolic process
AYWB_647	COG1078	dGTPase activity
AYWB_648	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AYWB_649	COG2088	sporulation resulting in formation of a cellular spore
AYWB_650	COG2217	Heavy metal translocating P-type atpase
AYWB_652	COG0275	rRNA processing
AYWB_653	COG0275	rRNA processing
AYWB_654	COG1758	RNA polymerase activity
AYWB_655	COG0194	GDP metabolic process
AYWB_656	COG0495	leucyl-tRNA aminoacylation
AYWB_657	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYWB_658	COG1363	Peptidase, m42
AYWB_660	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AYWB_661	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AYWB_662	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AYWB_663	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AYWB_664	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AYWB_665	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AYWB_669	COG1175	transmembrane transport
AYWB_670	COG3842	ATPase activity
AYWB_671	COG0017	Asparaginyl-tRNA synthetase