locus-tag class description Astex_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Astex_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Astex_0003 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Astex_0004 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Astex_0007 ENOG4105CDH Citrulline--aspartate ligase Astex_0009 ENOG4105DFH Transport of potassium into the cell (By similarity) Astex_0010 ENOG4108Z40 Transcriptional regulator Astex_0011 ENOG4105EMU Dehydrogenase Astex_0012 ENOG41081FY multiple antibiotic resistance (MarC)-related Astex_0013 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) Astex_0015 ENOG4105D0M Protease HtpX homolog Astex_0019 ENOG4105DC1 bifunctional purine biosynthesis protein purh Astex_0023 ENOG4105C31 Tryptophanyl-tRNA synthetase Astex_0024 ENOG4105CJR Integral membrane protein (MviN Astex_0033 ENOG4107SDU Methyl-accepting chemotaxis Astex_0034 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Astex_0035 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) Astex_0036 ENOG4105C6K Malic enzyme Astex_0037 ENOG4108E7F Transporter Astex_0038 ENOG4105BZU Histidine kinase Astex_0040 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Astex_0041 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Astex_0042 ENOG4105DJY efflux transporter, rnd family, mfp subunit Astex_0043 ENOG4105D7Z glutathione synthase Astex_0044 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) Astex_0046 ENOG4105CSA Coproporphyrinogen iii oxidase Astex_0047 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Astex_0049 ENOG4105VMP Transcriptional regulator Astex_0050 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) Astex_0054 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Astex_0055 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) Astex_0056 ENOG4105CFG Acts as a chaperone (By similarity) Astex_0057 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Astex_0058 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Astex_0060 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Astex_0061 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase Astex_0064 ENOG4105D7N magnesium and cobalt transport protein CorA Astex_0066 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) Astex_0067 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Astex_0079 ENOG4108E87 P-loop hydrolase UPF0079 Astex_0080 ENOG4105EHM Aminoglycoside phosphotransferase Astex_0081 ENOG4108S0S Nucleotidyl transferase Astex_0083 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation Astex_0084 ENOG4105K63 Thioredoxin Astex_0086 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) Astex_0090 ENOG4105CNU cell division protein FtsK Astex_0091 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Astex_0092 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Astex_0099 ENOG4105E2R ROK family Astex_0103 ENOG4105CBN LysR family transcriptional regulator Astex_0104 ENOG4105CHR reductase Astex_0106 ENOG4105NTW Transcriptional regulator Astex_0109 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Astex_0110 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Astex_0111 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Astex_0112 ENOG4105EQK -acetyltransferase Astex_0114 ENOG4108ZNX Heat shock protein Astex_0115 ENOG4105CYC Transferase Astex_0116 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN Astex_0117 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea Astex_0118 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Astex_0119 ENOG4108IUZ ABC transporter Astex_0122 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) Astex_0123 ENOG4105CSH Transporter Astex_0128 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Astex_0130 ENOG4105DFA alanine racemase domain protein Astex_0131 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Astex_0133 ENOG4105TXM Domain of unknown function (DUF3576) Astex_0134 ENOG4105C8T Leucyl-tRNA synthetase Astex_0137 ENOG4105FA0 parb-like partition protein Astex_0138 ENOG4107QJE Chromosome Partitioning Protein Astex_0139 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) Astex_0140 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) Astex_0141 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) Astex_0143 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) Astex_0144 ENOG4108YXA Membrane Astex_0145 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Astex_0146 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Astex_0148 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) Astex_0149 ENOG4108UHJ MAF-like protein Astex_0150 ENOG4105E2X shikimate dehydrogenase Astex_0151 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Astex_0153 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) Astex_0155 ENOG4105CA3 membrane-bound lytic murein transglycosylase Astex_0158 ENOG4105D7A ATP-binding protein Astex_0159 ENOG4105C7I Dehydrogenase Astex_0161 ENOG41083MR nifu domain-containing protein Astex_0162 ENOG41072GX Peptidase M22 Glycoprotease Astex_0164 ENOG41090R7 Ferric uptake Astex_0166 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Astex_0167 ENOG4105C9A Phoh family Astex_0168 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Astex_0169 ENOG4107RCQ (CBS) domain Astex_0170 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) Astex_0171 ENOG4108WRK Transcriptional regulator Astex_0172 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Astex_0173 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Astex_0175 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) Astex_0178 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Astex_0178 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Astex_0184 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Astex_0185 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Astex_0186 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Astex_0187 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Astex_0190 ENOG4105D8V Glucose sorbosone dehydrogenase Astex_0191 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Astex_0192 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Astex_0193 ENOG4107ZSV Receptor Astex_0194 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Astex_0195 ENOG4105DN3 alpha-2-macroglobulin domain protein Astex_0196 ENOG4108JQB penicillin-binding protein 1C Astex_0197 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) Astex_0198 ENOG4105KME endoribonuclease L-psp Astex_0199 ENOG4105K5M 30s ribosomal protein S16 Astex_0200 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY Astex_0203 ENOG4105CHM Aminotransferase Astex_0205 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Astex_0210 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Astex_0212 ENOG4107Z7P Ferredoxin Astex_0213 ENOG4105CJW magnesium transporter Astex_0215 ENOG4105I8F Histidine kinase Astex_0217 ENOG41082BM Transcriptional regulator, arsr family Astex_0219 ENOG4108UYB regulatoR Astex_0220 ENOG4105TX3 Histidine kinase Astex_0222 ENOG4105CZ9 Domain of unknown function (DU1801) Astex_0230 ENOG4108YYC ycei family Astex_0234 ENOG4105DNH Major Facilitator Astex_0235 ENOG4105CMV Succinyl-CoA synthetase subunit beta Astex_0236 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha Astex_0242 ENOG4107QN2 dihydrolipoyl dehydrogenase Astex_0246 ENOG4105BZE flagellar hook protein, FlgE Astex_0255 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Astex_0257 ENOG4105C25 Primosomal protein n' Astex_0259 ENOG4105EE5 Membrane protein terC Astex_0260 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Astex_0261 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Astex_0262 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Astex_0263 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Astex_0264 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Astex_0265 ENOG4105C8Q Methyl-accepting chemotaxis Astex_0267 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Astex_0268 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Astex_0269 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) Astex_0270 ENOG4107835 probably involved in intracellular septation (By similarity) Astex_0273 ENOG4105CHR reductase Astex_0275 ENOG4105EHI Phosphonate ABC transporter, periplasmic Astex_0276 ENOG4105D5T phosphonate abc transporter Astex_0277 ENOG4108NVR Methyl-accepting chemotaxis Astex_0281 ENOG4105E0R Deoxyhypusine synthase Astex_0284 ENOG41067SE Tetr family transcriptional regulator Astex_0286 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Astex_0287 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Astex_0290 ENOG4108ESY Metal dependent phosphohydrolase Astex_0291 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 Astex_0292 ENOG4105KCV RNA signal recognition particle 4.5S RNA Astex_0293 ENOG4105KCV RNA signal recognition particle 4.5S RNA Astex_0294 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Astex_0308 ENOG4108UUM single-stranded DNA-binding protein Astex_0311 ENOG4105Y2X UPF0335 protein Astex_0329 ENOG4105EFC phage portal protein HK97 family Astex_0330 ENOG4108N9J Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Astex_0359 ENOG4105FYV Amp nucleosidase Astex_0364 ENOG4106A3M Cytochrome p-450 Astex_0367 ENOG4105CX8 fg-gap repeat protein Astex_0370 ENOG4105EKC Astex_0373 ENOG4105DQ6 Transposase Astex_0374 ENOG4105HFZ Membrane Astex_0375 ENOG4105CI0 Citrate lyase Astex_0377 ENOG4105D6Z AFG1 family ATPase Astex_0378 ENOG4108JU3 Alkyl hydroperoxide reductase Astex_0379 ENOG4105ETX regulatoR Astex_0380 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) Astex_0385 ENOG4107XM9 (LipO)protein Astex_0387 ENOG4105CVM Molybdenum cofactor synthesis domain protein Astex_0388 ENOG4108RIR Molybdenum cofactor biosynthesis protein Astex_0389 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Astex_0390 ENOG4105EBR Carboxylesterase Astex_0391 ENOG4105K5X acetyltransferase Astex_0394 ENOG4107EJG GntR family transcriptional regulator Astex_0397 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) Astex_0399 ENOG4107WK2 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Astex_0400 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Astex_0402 ENOG4105K46 50S ribosomal protein l27 Astex_0403 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Astex_0404 ENOG4105CKI cobalamin synthesis protein Astex_0406 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase Astex_0408 ENOG4108UPT UPF0178 protein Astex_0411 ENOG4105C0H protease Astex_0412 ENOG4108ZG0 Ompa motb domain protein Astex_0414 ENOG4105C5E polysaccharide biosynthesis protein Astex_0415 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Astex_0417 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Astex_0432 ENOG4105CN1 protease Astex_0436 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Astex_0442 ENOG41060IM Heme exporter protein Astex_0443 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) Astex_0444 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) Astex_0445 ENOG4107QM5 aconitate hydratase Astex_0448 ENOG4107QIJ Aconitate hydratase 2 Astex_0450 ENOG4105D2H Uronic isomerase Astex_0451 ENOG4107KJX Transcriptional regulator Astex_0452 ENOG4105CTX dehydratase Astex_0453 ENOG4105DEI Mannitol dehydrogenase Astex_0454 ENOG4105CFF transcriptional regulator Astex_0461 ENOG4105C2M dna polymerase I Astex_0465 ENOG4105C8Q Methyl-accepting chemotaxis Astex_0466 ENOG4108NVR Methyl-accepting chemotaxis Astex_0468 ENOG4105E3W Two component transcriptional regulator (Winged helix family Astex_0469 ENOG4105EB3 Histidine kinase Astex_0470 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) Astex_0471 ENOG4108EQA pts system Astex_0472 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Astex_0476 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Astex_0477 ENOG4105E7A Glutamine amidotransferase Astex_0478 ENOG4108Z9K Osmotically inducible protein Astex_0479 ENOG4105CSR polyphosphate kinase 2 Astex_0484 ENOG4107TSN permease Astex_0487 ENOG4105DVT helicase Astex_0488 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Astex_0491 ENOG4105CIH Imidazole acetol-phosphate transaminase Astex_0493 ENOG4108Q5F Tetr family transcriptional regulator Astex_0497 ENOG4105TPV Astex_0498 ENOG4105C10 Electron transfer flavoprotein Astex_0499 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Astex_0501 ENOG4105DHF Membrane Astex_0502 ENOG4107ZT5 Thiol disulfide interchange protein Astex_0503 ENOG4105CH7 arginosuccinase Astex_0508 ENOG4105D9P serine threonine protein kinase Astex_0509 ENOG4107U4H Methyl-accepting chemotaxis Astex_0510 ENOG4105NWN ApaG protein Astex_0511 ENOG4105DHP deoxycytidine triphosphate deaminase Astex_0520 ENOG4105C8Y Acetylornithine aminotransferase Astex_0521 ENOG4105DBV ornithine carbamoyltransferase Astex_0522 ENOG4107RAN Peptidase, M16 Astex_0524 ENOG4108N8Y HfaB protein Astex_0525 ENOG41069UU holdfast attachment protein hfaa Astex_0534 ENOG4105FQP Beta-lactamase Astex_0540 ENOG4105HSS phospholipase C Astex_0541 ENOG4105DGI Alkaline phosphatase Astex_0543 ENOG4106KNT transcriptional regulator Astex_0552 ENOG4105CHJ isochorismatase hydrolase Astex_0555 ENOG4108ZXC Two component transcriptional regulator, luxr family Astex_0556 ENOG4105BZU Histidine kinase Astex_0557 ENOG4108ZXC Two component transcriptional regulator, luxr family Astex_0573 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Astex_0580 ENOG4107STW synthase Astex_0581 ENOG4108YXU transcriptional regulator AsnC family Astex_0585 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Astex_0589 ENOG4105W00 Flagellar hook capping protein Astex_0590 ENOG4105BZE flagellar hook protein, FlgE Astex_0592 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) Astex_0593 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) Astex_0596 ENOG4105DD5 Flagellar motor switch protein Astex_0597 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Astex_0599 ENOG4105D7B Flagellar biosynthesis protein flha Astex_0604 ENOG4108JIR Flagellum-specific ATP synthase Astex_0606 ENOG4105QNJ serralysin (EC 3.4.24.40) Astex_0608 ENOG4105EFQ Two component transcriptional regulator (Winged helix family Astex_0612 ENOG4105BZU Histidine kinase Astex_0613 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Astex_0614 ENOG4108MGY Histidine kinase Astex_0616 ENOG4105CBS Chea signal transduction histidine kinase Astex_0621 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) Astex_0623 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) Astex_0624 ENOG4105BZU Histidine kinase Astex_0625 ENOG4105BZU Histidine kinase Astex_0629 ENOG4105EQ0 Major Facilitator superfamily Astex_0630 ENOG4108UT2 hemolysin iii Astex_0631 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Astex_0633 ENOG4108VYJ response regulator receiver protein Astex_0637 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) Astex_0639 ENOG41085AN Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Astex_0643 ENOG4105DPW Major facilitator superfamily MFS_1 Astex_0644 ENOG4105DSG hydrolase family 43 Astex_0647 ENOG41080HT Transcriptional regulator, arsr family Astex_0651 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase Astex_0654 ENOG4105EEX Two component transcriptional regulator (Winged helix family Astex_0655 ENOG4105C08 Histidine kinase Astex_0656 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) Astex_0657 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Astex_0658 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) Astex_0664 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) Astex_0665 ENOG4108WIW Aspartyl protease Astex_0669 ENOG4108NVR Methyl-accepting chemotaxis Astex_0671 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Astex_0676 ENOG4107ZVW dihydroneopterin aldolase Astex_0678 ENOG4105C3M thioredoxin reductase Astex_0680 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Astex_0684 ENOG4105MHT Transcriptional regulator, ARSR family Astex_0686 ENOG4105KZX Pterin carbinolamine dehydratase Astex_0687 ENOG4105MIR Phenylalanine 4-monooxygenase Astex_0692 ENOG4105BZU Histidine kinase Astex_0693 ENOG4107Z5C methylesterase Astex_0694 ENOG4105BZU Histidine kinase Astex_0695 ENOG4105BZU Histidine kinase Astex_0698 ENOG4105C75 arginyL-tRNA synthetase Astex_0699 ENOG4108JU3 Alkyl hydroperoxide reductase Astex_0700 ENOG4105D3R alkyl hydroperoxide reductase Astex_0706 ENOG410856B UPF0235 protein Astex_0707 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Astex_0708 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Astex_0709 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Astex_0710 ENOG4105CM2 brancheD-chain amino acid aminotransferase Astex_0711 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Astex_0714 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Astex_0717 ENOG4105C01 Dihydroxy-acid dehydratase Astex_0722 ENOG4107QN1 sodium solute Astex_0723 ENOG41062QD Membrane Astex_0727 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Astex_0728 ENOG4105DEG Vwa containing coxe family protein Astex_0729 ENOG4105RD5 Astex_0730 ENOG4105KKX ATPase associated with various cellular activities aaa_5 Astex_0734 ENOG4108S2Y peptide Chain Release factor Astex_0735 ENOG4105E0Y RtcB Protein Astex_0745 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Astex_0746 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Astex_0747 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Astex_0750 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Astex_0756 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Astex_0759 ENOG4105D06 uba thif-type nad fad binding protein Astex_0761 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) Astex_0764 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) Astex_0768 ENOG4105KJF protein tyrosine phosphatase Astex_0776 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) Astex_0781 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) Astex_0783 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH Astex_0786 ENOG4105F6J Alpha beta hydrolase fold Astex_0788 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Astex_0789 ENOG4108YYC ycei family Astex_0790 ENOG4105D05 Receptor Astex_0798 ENOG4105CYM Glutathione S-transferase Astex_0799 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Astex_0800 ENOG4105C5W Aldolase Astex_0802 ENOG4108NKJ Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) Astex_0803 ENOG4105DHU Bile acid Astex_0806 ENOG4107S8C mandelate racemase muconate lactonizing Astex_0813 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Astex_0814 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Astex_0815 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Astex_0818 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Astex_0821 ENOG4105R8A Heat shock protein Astex_0822 ENOG4105HSS phospholipase C Astex_0823 ENOG4108HM4 ABC transporter Astex_0824 ENOG4105F38 ABC transporter, permease Astex_0825 ENOG4105D38 putrescine abc transporter Astex_0826 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Astex_0828 ENOG4105C9Q fumarate hydratase class II Astex_0831 ENOG4105KPY Small multidrug resistance protein Astex_0833 ENOG4105BZ1 (ABC) transporter Astex_0837 ENOG4105CKK Glycosyl transferase, family 2 Astex_0840 ENOG4108NVM synthesis repressor PhaR Astex_0842 ENOG4105CHR reductase Astex_0844 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Astex_0847 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Astex_0849 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Astex_0850 ENOG41061BG basal body P-ring formation protein flgA Astex_0851 ENOG4105CGA flagellar basal-body rod protein FlgG Astex_0852 ENOG4105KTQ flagellar basal-body rod protein Astex_0854 ENOG4105C19 ABC transporter Astex_0855 ENOG4105ENT Efflux transporter rnd family, mfp subunit Astex_0857 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Astex_0858 ENOG4108EU5 L-aspartate oxidase Astex_0860 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Astex_0861 ENOG4108RMU ferritin dps family protein Astex_0862 ENOG4108YZN class I peptide chain release factor Astex_0864 ENOG4105ESV Glycosyl transferase, family 4 Astex_0865 ENOG4105CHM Aminotransferase Astex_0868 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Astex_0873 ENOG4105RWF major outer membrane protein OmpA Astex_0874 ENOG4107G9V glycosyl transferase, family 39 Astex_0876 ENOG4105DWY Agmatine deiminase Astex_0879 ENOG4105CD3 dihydroorotase Astex_0883 ENOG4107QMP dna polymerase iii subunits gamma and tau Astex_0884 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Astex_0885 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Astex_0891 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Astex_0892 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Astex_0893 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Astex_0894 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Astex_0900 ENOG4105EXC Acyl-transferase Astex_0902 ENOG4105D7N magnesium and cobalt transport protein CorA Astex_0905 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Astex_0910 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Astex_0914 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Astex_0917 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Astex_0918 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Astex_0920 ENOG4105D44 asparaginase Astex_0921 ENOG4108JJ8 (ABC) transporter Astex_0922 ENOG4108JJ9 ABC, transporter Astex_0923 ENOG4105C4M (Ubiquinol oxidase) subunit I Astex_0924 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Astex_0926 ENOG4105C5E polysaccharide biosynthesis protein Astex_0928 ENOG4108ZAF Molybdopterin Astex_0929 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Astex_0930 ENOG4107RQ5 Methylates ribosomal protein L11 (By similarity) Astex_0932 ENOG4108Z86 Glutamine amidotransferase Astex_0934 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Astex_0937 ENOG4107SDU Methyl-accepting chemotaxis Astex_0938 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Astex_0939 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Astex_0940 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Astex_0941 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Astex_0944 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Astex_0945 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Astex_0946 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Astex_0947 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Astex_0948 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Astex_0949 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Astex_0950 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Astex_0951 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Astex_0952 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Astex_0953 ENOG41083MP 50s ribosomal protein l29 Astex_0954 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Astex_0955 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Astex_0956 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Astex_0957 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Astex_0958 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Astex_0959 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Astex_0960 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Astex_0961 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Astex_0962 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Astex_0963 ENOG41084HQ 50S ribosomal protein L30 Astex_0964 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Astex_0965 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Astex_0966 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Astex_0967 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Astex_0968 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Astex_0969 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Astex_0970 ENOG4108ZT0 50S ribosomal protein l17 Astex_0976 ENOG4105C0H protease Astex_0978 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) Astex_0988 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein Astex_0990 ENOG4105CSV Glutaminase Astex_0992 ENOG4105CNG UPF0061 protein Astex_0993 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Astex_0994 ENOG4107ZSV Receptor Astex_0997 ENOG4105J5T Amp-dependent synthetase and ligase Astex_1001 ENOG4105VDW Csbd family Astex_1005 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Astex_1007 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Astex_1011 ENOG4107XZ0 Peptidase M50 Astex_1012 ENOG4105C8Q Methyl-accepting chemotaxis Astex_1014 ENOG4105CJP fad dependent oxidoreductase Astex_1015 ENOG4105C5F glutamine synthetase Astex_1018 ENOG4105EX0 alpha-galactosidase Astex_1020 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Astex_1021 ENOG4105CR4 methylisocitrate lyase Astex_1022 ENOG4105BZN citrate synthase Astex_1023 ENOG4105DXD 2-methylcitrate dehydratase Astex_1027 ENOG4105BZU Histidine kinase Astex_1030 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Astex_1031 ENOG4105CKI cobalamin synthesis protein Astex_1033 ENOG4105DGI Alkaline phosphatase Astex_1035 ENOG4105CIG ABC transporter Astex_1042 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Astex_1045 ENOG4105CA0 peroxidase Astex_1049 ENOG4108UYB regulatoR Astex_1055 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Astex_1057 ENOG4105CAU Arsenical resistance protein, ArsH Astex_1063 ENOG4105ETE Transcriptional regulator (LacI family Astex_1066 ENOG4105GFR rna polymerase sigma factor Astex_1071 ENOG4105M6F mutator MutT protein Astex_1073 ENOG4105CGD Nad-dependent epimerase dehydratase Astex_1075 ENOG4108RTU Aldolase Astex_1076 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 Astex_1077 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein Astex_1078 ENOG4105CHU acetyl-coa acetyltransferase Astex_1079 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Astex_1080 ENOG4106KED esterase YpfH Astex_1089 ENOG4105KDC 50s ribosomal protein l28 Astex_1092 ENOG4105EN6 Membrane Astex_1096 ENOG4108Z4U Ferredoxin Astex_1103 ENOG4105DU1 integral membrane protein, terc Astex_1105 ENOG4105HFZ Membrane Astex_1107 ENOG4105C08 Histidine kinase Astex_1111 ENOG4105CJW magnesium transporter Astex_1114 ENOG4108VHN F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Astex_1116 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) Astex_1121 ENOG4107ZQN disulfide bond Astex_1123 ENOG4105CEN a g-specific adenine glycosylase Astex_1126 ENOG4105CEC DNA methylase N-4 N-6 Astex_1127 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Astex_1128 ENOG4105KAF membrAne Astex_1129 ENOG4105KAF membrAne Astex_1130 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Astex_1134 ENOG4105E39 Enoyl-CoA hydratase Astex_1137 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Astex_1138 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Astex_1139 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) Astex_1140 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Astex_1143 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Astex_1144 ENOG4105EST Metal Dependent Phosphohydrolase Astex_1146 ENOG4105C3G gtp-binding protein Astex_1147 ENOG4107S1E Beta-lactamase Astex_1149 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Astex_1150 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Astex_1152 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Astex_1156 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Astex_1159 ENOG4105II7 pyrroline-5-carboxylate reductase Astex_1163 ENOG4105K56 Transcriptional regulator Astex_1164 ENOG4108ZHJ Organic hydroperoxide resistance protein Astex_1165 ENOG4105CPC Aldo Keto reductase Astex_1167 ENOG4105C28 cystathionine Astex_1168 ENOG410846R homoserine O-acetyltransferase Astex_1172 ENOG4105D6E homoserine dehydrogenase Astex_1173 ENOG4105D1H recombination factor protein RarA Astex_1177 ENOG4105C34 Pseudouridine synthase Astex_1180 ENOG4108VTS Membrane Astex_1182 ENOG4105D6S protein involved in catabolism of external DNA Astex_1185 ENOG4105K8R UPF0145 protein Astex_1189 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Astex_1191 ENOG4108ZTZ UPF0262 protein Astex_1193 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Astex_1194 ENOG4108Z03 MAF-like protein Astex_1196 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Astex_1197 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Astex_1204 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Astex_1208 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Astex_1214 ENOG4105ETE Transcriptional regulator (LacI family Astex_1219 ENOG4107QK4 glycoside hydrolase, family 3 domain protein Astex_1220 ENOG4105CT4 transporter Astex_1221 ENOG4108N8Y HfaB protein Astex_1222 ENOG4108N8Y HfaB protein Astex_1223 ENOG41069UU holdfast attachment protein hfaa Astex_1225 ENOG4105CNT hydrolase family 2 Astex_1226 ENOG4105CNT hydrolase family 2 Astex_1229 ENOG4105DG4 malate L-lactate dehydrogenase Astex_1231 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Astex_1233 ENOG4105CUB amino acid Astex_1234 ENOG4105D7T ABC transporter Astex_1236 ENOG4105I5W Transporter Astex_1243 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) Astex_1246 ENOG4108UHE carbonic anhydrase Astex_1247 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Astex_1251 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) Astex_1252 ENOG4106909 Flagellar assembly regulator FliX Astex_1253 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters Astex_1256 ENOG4108URH decarboxylase Astex_1258 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Astex_1260 ENOG4105D07 Signal peptide peptidase, SppA Astex_1261 ENOG4105C72 UPF0176 protein Astex_1266 ENOG4105C1B dTDP-glucose 4-6-dehydratase Astex_1268 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) Astex_1269 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Astex_1270 ENOG4108HF7 Gcn5-related n-acetyltransferase Astex_1272 ENOG4105MWK D-amino acid dehydrogenase, small subunit Astex_1273 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Astex_1278 ENOG4105ENT Efflux transporter rnd family, mfp subunit Astex_1279 ENOG4108IND Tetr family transcriptional regulator Astex_1286 ENOG4105CI3 gtp-binding protein typa Astex_1291 ENOG4107E2E PKHD-type hydroxylase Astex_1295 ENOG4105CJ2 (LipO)protein Astex_1298 ENOG4105EXX Deoxyribodipyrimidine photolyase-related protein Astex_1301 ENOG4107ZSV Receptor Astex_1302 ENOG4107RDJ Sulfotransferase Astex_1303 ENOG4105C26 Dehydrogenase Astex_1309 ENOG4105C26 Dehydrogenase Astex_1310 ENOG4105EW9 transcriptional regulator AsnC family Astex_1311 ENOG4105E2V Glycosyltransferase 36 Astex_1316 ENOG4105BZU Histidine kinase Astex_1318 ENOG4108ZJ4 polysaccharide deacetylase Astex_1320 ENOG4108RVA ribokinase Astex_1322 ENOG4105DU0 nucleoside hydrolase Astex_1325 ENOG4107S5I aldo keto reductase Astex_1326 ENOG4105CH2 amidohydrolase Astex_1329 ENOG4108EHY type IV secretion system Astex_1333 ENOG4105EJX conjugal transfer ATPase Astex_1336 ENOG4105E4C Lytic transglycosylase catalytic Astex_1340 ENOG4105E3B Multicopper oxidase Astex_1343 ENOG4105ETE Transcriptional regulator (LacI family Astex_1344 ENOG4105CSH Transporter Astex_1346 ENOG4108MGY Histidine kinase Astex_1349 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Astex_1350 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Astex_1351 ENOG41081BE Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) Astex_1353 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Astex_1354 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Astex_1355 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Astex_1359 ENOG4107T0X DNA ligase Astex_1360 ENOG4107T0X DNA ligase Astex_1361 ENOG4107QRT dEAD DEAH box helicase Astex_1366 ENOG4105ETE Transcriptional regulator (LacI family Astex_1369 ENOG4107QW3 Sucrose phosphorylase Astex_1370 ENOG4105EVU fructokinase Astex_1371 ENOG4105FDF Could be involved in DNA repair (By similarity) Astex_1372 ENOG4105DQE DNA ligase Astex_1373 ENOG4107QK4 glycoside hydrolase, family 3 domain protein Astex_1375 ENOG4106FKC arabinogalactan endo-1,4-beta-galactosidase Astex_1384 ENOG4107TDE lipolytic protein G-D-S-L family Astex_1390 ENOG41088BU Domain of unknown function (DUF329) Astex_1392 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Astex_1395 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) Astex_1398 ENOG4105CFC Transporter Astex_1401 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Astex_1402 ENOG4105CTB Polyprenyl synthetase Astex_1403 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Astex_1405 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Astex_1408 ENOG4105K6V RNA polymerase Astex_1413 ENOG4107EJG GntR family transcriptional regulator Astex_1416 ENOG4105D00 flagellar biosynthetic protein flhB Astex_1417 ENOG4105D19 Role in flagellar biosynthesis (By similarity) Astex_1418 ENOG41082PJ flagellar biosynthetic protein fliQ Astex_1419 ENOG4105UVF flagellar hook-basal body complex protein fliE Astex_1420 ENOG4108ZC9 flagellar basal-body rod protein flgc Astex_1422 ENOG410680W Flagellar biosynthesis protein, FliO Astex_1423 ENOG4105CN7 Flagellar biosynthetic protein FliP Astex_1438 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase Astex_1441 ENOG4107QWP ABC-2 type transporter Astex_1443 ENOG4105CJ1 ABC, transporter Astex_1445 ENOG4108R86 Transcriptional regulator Astex_1448 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) Astex_1452 ENOG4105D4P Coproporphyrinogen iii oxidase Astex_1457 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA Astex_1462 ENOG4105BZU Histidine kinase Astex_1463 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Astex_1464 ENOG4105C0R drug resistance transporter emrb qaca subfamily Astex_1465 ENOG4105CW7 secretion protein, HlyD family Astex_1467 ENOG4105YA8 Transcriptional regulator Astex_1481 ENOG41090BB DNA mismatch endonuclease (vsr) Astex_1493 ENOG4108I62 cina-like protein Astex_1494 ENOG4105PW4 Sugar fermentation stimulation protein homolog Astex_1497 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Astex_1508 ENOG4105KK4 UPF0060 membrane protein Astex_1509 ENOG4107QI1 Mate efflux family protein Astex_1511 ENOG4108W2P Methyl-accepting chemotaxis Astex_1512 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase Astex_1515 ENOG4105E66 phosphoriboisomerase A Astex_1516 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Astex_1517 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Astex_1518 ENOG4105CKD glutathione-regulated potassium-efflux system protein Astex_1520 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Astex_1531 ENOG4105EB3 Histidine kinase Astex_1534 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Astex_1539 ENOG4108ZZF transport protein (ExbD) Astex_1541 ENOG4105CVE Lytic murein transglycosylase Astex_1546 ENOG4105Y2X UPF0335 protein Astex_1549 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Astex_1554 ENOG4105NX3 Membrane Astex_1555 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Astex_1556 ENOG4105W8H transhydrogenase (subunit alpha Astex_1557 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) Astex_1558 ENOG4105DQ6 Transposase Astex_1561 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Astex_1562 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Astex_1563 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Astex_1567 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Astex_1568 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Astex_1571 ENOG4108Z0R Transferase Astex_1572 ENOG4105C9A Phoh family Astex_1577 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Astex_1579 ENOG4105D9N nucleoside Astex_1580 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Astex_1581 ENOG4105E0F Histidine kinase Astex_1587 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) Astex_1589 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Astex_1594 ENOG4107TK4 histidinol-phosphate phosphatase Astex_1600 ENOG4107QK4 glycoside hydrolase, family 3 domain protein Astex_1602 ENOG4105VFE sira family Astex_1606 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Astex_1607 ENOG4105FAT Acyl-transferase Astex_1609 ENOG4105FGE Short-chain dehydrogenase reductase Sdr Astex_1610 ENOG4105EAH synthase Astex_1611 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) Astex_1612 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Astex_1616 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Astex_1617 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Astex_1622 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Astex_1625 ENOG4105C8Q Methyl-accepting chemotaxis Astex_1628 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Astex_1630 ENOG4105CNI cell division protein FtsW Astex_1631 ENOG4105CJN penicillin-binding protein Astex_1636 ENOG4105CDY transcriptional regulatory protein Astex_1637 ENOG4105D48 metallophosphoesterase Astex_1639 ENOG4105DU1 integral membrane protein, terc Astex_1640 ENOG4107QK4 glycoside hydrolase, family 3 domain protein Astex_1646 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) Astex_1647 ENOG4105I08 Pseudouridine synthase Astex_1649 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Astex_1650 ENOG4105JJR Histidine kinase Astex_1652 ENOG4105BZA Phosphoglycerate kinase Astex_1653 ENOG4105D2N Aldolase Astex_1654 ENOG4108ZNX Heat shock protein Astex_1656 ENOG4105C28 cystathionine Astex_1657 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein Astex_1658 ENOG4108I5D sulfate abc transporter Astex_1660 ENOG4108IJ6 ABC transporter Astex_1662 ENOG4105EMU Dehydrogenase Astex_1664 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Astex_1666 ENOG4105DC7 peptidase M24 Astex_1668 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Astex_1669 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Astex_1670 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Astex_1671 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Astex_1672 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Astex_1673 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) Astex_1674 ENOG4108UFP Essential cell division protein (By similarity) Astex_1679 ENOG4105KCK Peptidoglycan-associated lipoprotein Astex_1680 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) Astex_1682 ENOG4105SG9 biopolymer transport protein, ExbD Astex_1684 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Astex_1685 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Astex_1686 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Astex_1692 ENOG4105C5H ABC transporter Astex_1693 ENOG4105BZU Histidine kinase Astex_1694 ENOG4105FDP GntR family transcriptional regulator Astex_1697 ENOG4105RD7 BadF BadG BcrA BcrD Astex_1698 ENOG4105CE4 GlcNAc 6-P deacetylase Astex_1699 ENOG4108ZG0 Ompa motb domain protein Astex_1705 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase Astex_1713 ENOG4106HMZ Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Astex_1715 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Astex_1716 ENOG4105ECY inositol monophosphatase Astex_1717 ENOG4108JGH Tetr family transcriptional regulator Astex_1719 ENOG4105BZ1 (ABC) transporter Astex_1720 ENOG41082FS 50S ribosomal protein L31 Astex_1724 ENOG4105CAS nag kinase Astex_1728 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) Astex_1730 ENOG4107S01 Repressor protein MetJ Astex_1731 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Astex_1732 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) Astex_1733 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) Astex_1739 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Astex_1741 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) Astex_1742 ENOG4105C01 Dihydroxy-acid dehydratase Astex_1745 ENOG4105C26 Dehydrogenase Astex_1750 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Astex_1758 ENOG4105C22 threonyL-tRNA synthetase Astex_1759 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Astex_1763 ENOG4105C8N cysteinyl-tRNA synthetase Astex_1764 ENOG4105EUJ GTP cyclohydrolase i Astex_1765 ENOG4108ZZF transport protein (ExbD) Astex_1767 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Astex_1768 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Astex_1771 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Astex_1775 ENOG4105DWF phosphomethylpyrimidine kinase Astex_1779 ENOG4105EEI dihydropteroate synthase Astex_1780 ENOG4105D4A Cell wall formation (By similarity) Astex_1781 ENOG4105DFU Cell wall formation (By similarity) Astex_1785 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Astex_1789 ENOG41082BR 50S ribosomal protein L35 Astex_1790 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Astex_1791 ENOG4105CFQ glutamine synthetase Astex_1792 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Astex_1793 ENOG4105C26 Dehydrogenase Astex_1794 ENOG4105C26 Dehydrogenase Astex_1797 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Astex_1801 ENOG4105PGM cation diffusion facilitator family transporter Astex_1809 ENOG4105DCF alanine dehydrogenase Astex_1819 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Astex_1820 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Astex_1827 ENOG4105KK3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Astex_1828 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Astex_1829 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) Astex_1833 ENOG4105D7W serine acetyltransferase Astex_1834 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) Astex_1838 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) Astex_1840 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Astex_1842 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) Astex_1843 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Astex_1846 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Astex_1847 ENOG4107YUR Cell division protein mraZ Astex_1851 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase Astex_1853 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) Astex_1858 ENOG4105DC7 peptidase M24 Astex_1859 ENOG4105C3R Methionine synthase Astex_1862 ENOG4105CPF Cell wall formation (By similarity) Astex_1863 ENOG4105C3R Methionine synthase Astex_1865 ENOG4105SYT Methylenetetrahydrofolate reductase Astex_1866 ENOG41089UC methyltransferase, type 11 Astex_1868 ENOG4106YAV Domain of unknown function (DUF1508) Astex_1870 ENOG4105F0N pyrophosphate phospho-hydrolase Astex_1874 ENOG41067HS methyltransferase Astex_1876 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family Astex_1890 ENOG4105EBR Carboxylesterase Astex_1891 ENOG4105DKQ ROK family Astex_1893 ENOG4105QV4 Tryptophan halogenase Astex_1896 ENOG4105CA9 Pyruvate kinase Astex_1897 ENOG4105KG3 cytidine deaminase Astex_1899 ENOG4105EDR glucose galactose transporter Astex_1901 ENOG41069M3 Transcriptional regulator Astex_1904 ENOG4105CTX dehydratase Astex_1905 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr Astex_1908 ENOG4107QNK )-transporter Astex_1909 ENOG4105C01 Dihydroxy-acid dehydratase Astex_1910 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein Astex_1913 ENOG4105ETE Transcriptional regulator (LacI family Astex_1920 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Astex_1921 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Astex_1926 ENOG41069M3 Transcriptional regulator Astex_1927 ENOG4107QP3 malate synthase g Astex_1929 ENOG4105CNT hydrolase family 2 Astex_1931 ENOG4105CHR reductase Astex_1933 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) Astex_1934 ENOG4105E0C molybdate abc transporter Astex_1935 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Astex_1936 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Astex_1938 ENOG4105CE1 Ferrous iron transport protein b Astex_1941 ENOG4105C7N Xanthine uracil vitamin C permease Astex_1949 ENOG4105ETE Transcriptional regulator (LacI family Astex_1950 ENOG4108UHU Aldolase Astex_1951 ENOG4105CHC glucokinase (EC 2.7.1.2) Astex_1952 ENOG4105C01 Dihydroxy-acid dehydratase Astex_1953 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) Astex_1958 ENOG4105CD8 aminopeptidase N Astex_1959 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Astex_1960 ENOG4105BZU Histidine kinase Astex_1961 ENOG4105DXC membrane Astex_1965 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) Astex_1968 ENOG4105EB3 Histidine kinase Astex_1972 ENOG4108JJ7 ABC transporter Astex_1974 ENOG4107ZXU DSBA oxidoreductase Astex_1975 ENOG4108SA1 esterase Astex_1977 ENOG4105ETE Transcriptional regulator (LacI family Astex_1979 ENOG4105EJQ L-serine dehydratase Astex_1986 ENOG4105ETE Transcriptional regulator (LacI family Astex_1988 ENOG4105QV4 Tryptophan halogenase Astex_1992 ENOG41067TZ transcriptional regulator, MarR family Astex_1993 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Astex_1996 ENOG4105BZU Histidine kinase Astex_1997 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Astex_1998 ENOG4105BZU Histidine kinase Astex_2005 ENOG4107EJG GntR family transcriptional regulator Astex_2009 ENOG4105WH1 Two component transcriptional regulator luxr family Astex_2011 ENOG4108Z18 K06886 hemoglobin Astex_2013 ENOG4105KWW Biogenesis protein Astex_2014 ENOG4105DA4 cytochrome c-type biogenesis protein Astex_2015 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) Astex_2018 ENOG4105IFJ Histidine kinase Astex_2019 ENOG4105XJC Two component transcriptional regulator (Winged helix family Astex_2022 ENOG4108ZZ3 UPF0260 protein Astex_2023 ENOG4105C5H ABC transporter Astex_2027 ENOG4105C5Q Transcriptional regulator Astex_2028 ENOG4107QX3 carboxylase Astex_2029 ENOG41060WC Enoyl-CoA hydratase Astex_2030 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Astex_2031 ENOG4105C1G acyl-Coa dehydrogenase Astex_2032 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Astex_2034 ENOG4108UKI Enoyl-CoA hydratase Astex_2037 ENOG4108XM1 transcriptional regulator AsnC family Astex_2045 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Astex_2047 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Astex_2048 ENOG4105C1G acyl-Coa dehydrogenase Astex_2049 ENOG4105C26 Dehydrogenase Astex_2050 ENOG4105CJP fad dependent oxidoreductase Astex_2051 ENOG4108MGI Transcriptional regulator Astex_2058 ENOG4105ETE Transcriptional regulator (LacI family Astex_2059 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase Astex_2064 ENOG4107RTG Major Facilitator superfamily Astex_2065 ENOG410642W LysR family Transcriptional regulator Astex_2066 ENOG4105CPC Aldo Keto reductase Astex_2069 ENOG4105CC0 LysR family Transcriptional regulator Astex_2070 ENOG4105ENX hydrolase Astex_2072 ENOG4105E0Y RtcB Protein Astex_2084 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Astex_2086 ENOG41076HS cation diffusion facilitator family transporter Astex_2088 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) Astex_2090 ENOG4107QP8 phosphohexose isomerase Astex_2094 ENOG4105BZU Histidine kinase Astex_2096 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase Astex_2097 ENOG4105C26 Dehydrogenase Astex_2101 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Astex_2103 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) Astex_2105 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) Astex_2106 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) Astex_2107 ENOG4108JQ1 Dehydrogenase Astex_2112 ENOG4105C1J atp-dependent rna helicase Astex_2114 ENOG4108MGY Histidine kinase Astex_2118 ENOG4105F5H Glycosyl Hydrolase Family 88 Astex_2121 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component Astex_2122 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component Astex_2131 ENOG4105CHR reductase Astex_2132 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) Astex_2134 ENOG4105J4Q Transcriptional regulator Astex_2135 ENOG4105CXK mandelate racemase muconate lactonizing Astex_2137 ENOG4106517 Short-chain dehydrogenase reductase Sdr Astex_2141 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Astex_2146 ENOG4105CHR reductase Astex_2148 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Astex_2151 ENOG4105F0R Cytidylyltransferase Astex_2152 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Astex_2159 ENOG4107TDE lipolytic protein G-D-S-L family Astex_2165 ENOG4105E4G Type IV pilus Astex_2169 ENOG4105C9F isomerase Astex_2173 ENOG4105C0D helicase Astex_2179 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Astex_2181 ENOG4105D3Q Sugar transferase Astex_2199 ENOG4105E5H Transposase Astex_2212 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Astex_2213 ENOG4105C6Y Udp-glucose 6-dehydrogenase Astex_2214 ENOG4108IAJ Nad-dependent epimerase dehydratase Astex_2215 ENOG4108TJN glycosyl transferase group 1 Astex_2220 ENOG4105D3Q Sugar transferase Astex_2221 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) Astex_2248 ENOG4105VT3 DNA binding domain protein, excisionase family Astex_2250 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Astex_2251 ENOG4108TPP exopolysaccharide synthesis Astex_2252 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Astex_2262 ENOG4105DGW oligopeptidase A Astex_2263 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Astex_2264 ENOG4107RGC Glycosyl transferase, family 2 Astex_2280 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase Astex_2283 ENOG4105CPK Glycosyl transferase (Group 1 Astex_2284 ENOG4105C2X Arabinose 5-phosphate isomerase Astex_2285 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) Astex_2286 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase Astex_2288 ENOG4105C11 sulfate adenylyltransferase), subunit 2 Astex_2289 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase Astex_2290 ENOG4107SZR mannose-6-phosphate isomerase Astex_2296 ENOG4107104 thymidine kinase Astex_2300 ENOG4108WRK Transcriptional regulator Astex_2303 ENOG41077A9 carbonic anhydrase Astex_2307 ENOG4105C7B Threonine dehydratase Astex_2308 ENOG4108V1T peptidylprolyl cis-trans isomerase Astex_2309 ENOG4105CMR udp-glucose 4-epimerase Astex_2310 ENOG4107QKV phosphomannomutase Astex_2313 ENOG4105D0A hydroxylase Astex_2314 ENOG4105C5Q Transcriptional regulator Astex_2315 ENOG4105W49 UPF0434 protein Astex_2316 ENOG4105K63 Thioredoxin Astex_2317 ENOG4105C0R drug resistance transporter emrb qaca subfamily Astex_2319 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Astex_2320 ENOG4108UTW Plays a role in the regulation of phosphate uptake Astex_2321 ENOG4105BZU Histidine kinase Astex_2322 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Astex_2324 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Astex_2325 ENOG4105D98 threonine synthase Astex_2328 ENOG4105BZU Histidine kinase Astex_2329 ENOG4105BZU Histidine kinase Astex_2336 ENOG4105CAY ferredoxin--nadp reductase Astex_2337 ENOG4105ETT transcriptional Regulator, LysR family Astex_2339 ENOG4105CUV Homoserine Kinase Astex_2352 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Astex_2353 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Astex_2356 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Astex_2358 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) Astex_2359 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Astex_2360 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Astex_2361 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Astex_2363 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Astex_2364 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) Astex_2365 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Astex_2366 ENOG4105CAT Cytidine monophosphate kinase Astex_2369 ENOG4107MBT Plasmid stabilisation system protein Astex_2373 ENOG4105CPC Aldo Keto reductase Astex_2374 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) Astex_2375 ENOG4107AQZ Membrane Astex_2376 ENOG4105C2C drug resistance transporter, Bcr CflA Astex_2377 ENOG4105C9U ATP-dependent DNA helicase RecQ Astex_2378 ENOG4108JQC penicillin-binding protein 1A Astex_2380 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Astex_2381 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) Astex_2385 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA Astex_2395 ENOG4107ZSV Receptor Astex_2397 ENOG4105CA0 peroxidase Astex_2401 ENOG4108SF5 RNA Polymerase Astex_2403 ENOG4105D2S major facilitator superfamily Astex_2405 ENOG4105DDW LysR family Transcriptional regulator Astex_2406 ENOG4107F9Y LysR family transcriptional regulator Astex_2407 ENOG4105JSC dimethylmenaquinone methyltransferase Astex_2410 ENOG4105KHM amidohydrolase 2 Astex_2419 ENOG4105WH1 Two component transcriptional regulator luxr family Astex_2422 ENOG4107S1E Beta-lactamase Astex_2427 ENOG4106S2D Transcriptional regulator Astex_2432 ENOG4105BZ1 (ABC) transporter Astex_2441 ENOG4108IND Tetr family transcriptional regulator Astex_2460 ENOG4108YXV Transcriptional regulator Astex_2461 ENOG4105K70 DNA-binding protein Astex_2463 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Astex_2466 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Astex_2467 ENOG4107QK4 glycoside hydrolase, family 3 domain protein Astex_2468 ENOG4105CZM Major Facilitator Astex_2471 ENOG4105DVW rieske (2Fe-2S) Astex_2472 ENOG4105EMU Dehydrogenase Astex_2474 ENOG4105EBR Carboxylesterase Astex_2476 ENOG4105ECQ AraC Family Transcriptional Regulator Astex_2478 ENOG4105DHU Bile acid Astex_2492 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Astex_2493 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) Astex_2497 ENOG4108K2F hydrolase Family 5 Astex_2502 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Astex_2503 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Astex_2504 ENOG4105V9V Short-chain dehydrogenase reductase Sdr Astex_2509 ENOG4108PC0 lipolytic protein G-D-S-L family Astex_2511 ENOG4105CVS RNA methyltransferase TrmH family, group 1 Astex_2513 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) Astex_2514 ENOG4108K4C ec 3.1.3.12 Astex_2515 ENOG4105BZP glycoside hydrolase 15-related Astex_2516 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase Astex_2518 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Astex_2519 ENOG4105EUB pirin domain protein Astex_2520 ENOG4105HEI LysR family (Transcriptional regulator Astex_2523 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Astex_2525 ENOG4105C5R Aminotransferase Astex_2529 ENOG4105E1J oxidoreductase Astex_2530 ENOG4105VT2 5-hydroxyisourate hydrolase Astex_2531 ENOG4107YV9 domain protein Astex_2532 ENOG4105C7W Xanthine dehydrogenase Astex_2534 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Astex_2535 ENOG4107QUY Guanine deaminase Astex_2536 ENOG4108YX9 iron--sulfur cluster insertion protein erpA Astex_2537 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Astex_2539 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase Astex_2540 ENOG4105BZU Histidine kinase Astex_2542 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit Astex_2544 ENOG4105K5G 30S ribosomal protein S21 Astex_2551 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase Astex_2552 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Astex_2556 ENOG4107RD7 Flagellar Motor Protein, MotA Astex_2558 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) Astex_2564 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Astex_2566 ENOG4105X54 addiction module antidote protein Astex_2575 ENOG4105D9R oxidoreductase Astex_2586 ENOG4105QV4 Tryptophan halogenase Astex_2589 ENOG4105EX0 alpha-galactosidase Astex_2591 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Astex_2594 ENOG4105CNT hydrolase family 2 Astex_2597 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Astex_2598 ENOG4105D7T ABC transporter Astex_2599 ENOG4108IFG nitrite reductase, (NAD(P)H) Astex_2602 ENOG4105CNT hydrolase family 2 Astex_2603 ENOG4105EUB pirin domain protein Astex_2612 ENOG4105DUX Transporter Astex_2614 ENOG4105D1U peptidase U62 modulator of DNA gyrase Astex_2615 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) Astex_2616 ENOG4105BZ9 Cytochrome C oxidase, subunit I Astex_2617 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Astex_2619 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) Astex_2620 ENOG4107QS1 Cytochrome C Oxidase, Subunit III Astex_2622 ENOG4108R6F Surfeit locus 1 family protein Astex_2623 ENOG4105C1V Peptidase, M16 Astex_2624 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase Astex_2625 ENOG4108UJU UPF0301 protein Astex_2626 ENOG4105EHV domain protein Astex_2627 ENOG4105CSU acyl-Coa dehydrogenase Astex_2629 ENOG4105DK7 lysyl-tRNA synthetase Astex_2634 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) Astex_2635 ENOG4107RJX Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) Astex_2636 ENOG4105C9X ppx gppa phosphatase Astex_2639 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Astex_2643 ENOG4105CIH Imidazole acetol-phosphate transaminase Astex_2644 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) Astex_2646 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Astex_2648 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) Astex_2655 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B Astex_2656 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Astex_2658 ENOG4105F5W AtP-binding protein Astex_2660 ENOG4105DFP Integrase Astex_2687 ENOG4105E0F Histidine kinase Astex_2688 ENOG4105DPZ Two component transcriptional regulator (Winged helix family Astex_2691 ENOG4105KUZ arsenate reductase Astex_2693 ENOG4105GFR rna polymerase sigma factor Astex_2695 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Astex_2698 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Astex_2699 ENOG4105JAB phenazine biosynthesis protein, phzf family Astex_2701 ENOG4105CHR reductase Astex_2702 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase Astex_2705 ENOG4105CDU Replicative dna helicase Astex_2708 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Astex_2712 ENOG4105CK2 sodium dicarboxylate symporter Astex_2713 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Astex_2715 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Astex_2716 ENOG41083B3 HAD-superfamily subfamily IB hydrolase Astex_2717 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Astex_2719 ENOG4105RD7 BadF BadG BcrA BcrD Astex_2720 ENOG4106N3A copper homeostasis protein cutc Astex_2727 ENOG4105CWX Alpha-1,2-mannosidase Astex_2730 ENOG4105FDP GntR family transcriptional regulator Astex_2731 ENOG4105CPE K01197 hyaluronoglucosaminidase EC 3.2.1.35 Astex_2732 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Astex_2733 ENOG4105KAF membrAne Astex_2734 ENOG4105C2N RNA methyltransferase TrmH family group 3 Astex_2736 ENOG4108ZCF integral membrane protein Astex_2737 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) Astex_2738 ENOG4108VTS Membrane Astex_2739 ENOG4105WD1 Membrane Astex_2743 ENOG410683Z Preprotein translocase SecE subunit Astex_2744 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) Astex_2745 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Astex_2746 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Astex_2747 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase Astex_2748 ENOG4105ECQ AraC Family Transcriptional Regulator Astex_2749 ENOG4108VZM 50s ribosomal protein L10 Astex_2750 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Astex_2753 ENOG4105DR5 peptidase Astex_2754 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Astex_2756 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Astex_2757 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) Astex_2758 ENOG4105DHZ alpha beta Astex_2759 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family Astex_2760 ENOG4105C3J Cysteine desulfurase Astex_2764 ENOG4105JRK feS assembly protein SufD Astex_2765 ENOG4105C9B Cysteine desulfurase Astex_2766 ENOG4105VG1 fes assembly suf system protein Astex_2767 ENOG4108Z4V iron-sulfur cluster assembly Astex_2771 ENOG4106TD9 Diguanylate cyclase Astex_2772 ENOG4105C1J atp-dependent rna helicase Astex_2773 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Astex_2776 ENOG4105BZU Histidine kinase Astex_2777 ENOG4105C5F glutamine synthetase Astex_2779 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Astex_2780 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Astex_2781 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Astex_2782 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) Astex_2783 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen Astex_2784 ENOG4108MXZ Esterase Astex_2786 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) Astex_2787 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Astex_2789 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Astex_2790 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) Astex_2791 ENOG4105HHA aminodeoxychorismate lyase Astex_2792 ENOG4105DSJ YicC domain protein Astex_2793 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Astex_2797 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Astex_2798 ENOG4105K70 DNA-binding protein Astex_2802 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Astex_2803 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Astex_2804 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Astex_2805 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Astex_2807 ENOG4105GKE subunit e Astex_2808 ENOG4107QIZ NADH dehydrogenase Astex_2809 ENOG4105YB8 TM2 domain containing protein Astex_2810 ENOG4107R0R NADH dehydrogenase subunit g Astex_2811 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Astex_2812 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Astex_2813 ENOG4105DF2 NADH dehydrogenase subunit j Astex_2814 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Astex_2815 ENOG4105D65 subunit l Astex_2816 ENOG4105C8S subunit m Astex_2817 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Astex_2818 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Astex_2819 ENOG4107QNB Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Astex_2821 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class Astex_2823 ENOG4105CBT Fructose-1,6-bisphosphatase Astex_2824 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) Astex_2825 ENOG4105VEQ Cold shock protein Astex_2828 ENOG4105F7V ErfK ybiS ycfS ynhG family protein Astex_2832 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) Astex_2834 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Astex_2835 ENOG4108UJD 30S ribosomal protein S9 Astex_2836 ENOG4107SQ0 N-acetyl-gamma-glutamyl-phosphate reductase Astex_2839 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Astex_2840 ENOG4105D60 lipoprotein releasing system transmembrane protein Astex_2841 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Astex_2842 ENOG4105C0B DNA polymerase III (alpha subunit) Astex_2843 ENOG4105CE9 30S ribosomal protein S2 Astex_2844 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Astex_2845 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Astex_2846 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Astex_2847 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Astex_2848 ENOG4105KNE Phosphatidate cytidylyltransferase Astex_2849 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Astex_2850 ENOG4105DZP Membrane-associated zinc metalloprotease Astex_2851 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane Astex_2853 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Astex_2854 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Astex_2855 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Astex_2856 ENOG4105GYT Protein of unknown function (DUF1009) Astex_2857 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) Astex_2858 ENOG4105FQP Beta-lactamase Astex_2859 ENOG4105BZN citrate synthase Astex_2862 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Astex_2863 ENOG4105DK0 Indole-3-glycerol phosphate synthase Astex_2864 ENOG4108I0Q anthranilate phosphoribosyltransferase Astex_2865 ENOG4105DDQ anthranilate synthase Astex_2867 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Astex_2868 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) Astex_2869 ENOG4105F0I Aminotransferase Astex_2870 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Astex_2871 ENOG4105ES5 Histidine kinase Astex_2873 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Astex_2874 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Astex_2875 ENOG4105F8V Hydrolase, tatD family Astex_2876 ENOG4107QRG dna polymerase iii Astex_2877 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Astex_2878 ENOG4105K6T rare lipoprotein A Astex_2885 ENOG4105Y75 tpr repeat protein Astex_2886 ENOG4105CB5 ATP-dependent DNA helicase recG Astex_2889 ENOG4106WTF Glycosyl transferase, family 2 Astex_2890 ENOG4105CVP deoxyribo-dipyrimidine photolyase Astex_2891 ENOG4105KHC sulfurtransferase Astex_2892 ENOG4107QXX ABC transporter Astex_2894 ENOG4108176 endoribonuclease L-psp Astex_2895 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Astex_2897 ENOG4105CP7 Triose-phosphate isomerase Astex_2899 ENOG4105CRQ synthase (Component I) Astex_2901 ENOG4105CKD glutathione-regulated potassium-efflux system protein Astex_2902 ENOG4107RBJ symporter Astex_2903 ENOG4105DXN mazG family Astex_2904 ENOG4108MR6 WD40-like Beta Propeller Repeat Astex_2907 ENOG4105CJ1 ABC, transporter Astex_2909 ENOG4105CEV competence damage-inducible protein Astex_2910 ENOG4108Z1B Cyclase dehydrase Astex_2911 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Astex_2913 ENOG4105CEY Amp-dependent synthetase and ligase Astex_2915 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Astex_2918 ENOG4107QN2 dihydrolipoyl dehydrogenase Astex_2919 ENOG4105C7S Dehydrogenase Astex_2920 ENOG4105CPP Dehydrogenase, E1 component Astex_2921 ENOG4108JYK Dehydrogenase Astex_2922 ENOG4106ABQ septum formation initiator Astex_2923 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Astex_2924 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 Astex_2925 ENOG41082R8 50S ribosomal protein l32 Astex_2927 ENOG4105WJX transcriptional regulator MERR family Astex_2928 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) Astex_2929 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Astex_2930 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Astex_2934 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Astex_2936 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Astex_2937 ENOG4107XZX Involved in the transcription termination process (By similarity) Astex_2938 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Astex_2941 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) Astex_2942 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Astex_2943 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Astex_2947 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Astex_2949 ENOG4105D52 delta-aminolevulinic acid dehydratase Astex_2950 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase Astex_2952 ENOG4105ER2 Ompa motb domain protein Astex_2953 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate Astex_2954 ENOG4108TPP exopolysaccharide synthesis Astex_2956 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Astex_2959 ENOG4107UIS Involved in DNA repair and RecF pathway recombination (By similarity) Astex_2960 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Astex_2961 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Astex_2962 ENOG4105C3F Signal peptidase i Astex_2963 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Astex_2964 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) Astex_2965 ENOG4107VCP Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Astex_2967 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Astex_2969 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Astex_2971 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Astex_2972 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Astex_2973 ENOG4107SC1 transglycosylase Astex_2974 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Astex_2975 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) Astex_2978 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) Astex_2979 ENOG4108RWN rrna methyltransferase Astex_2983 ENOG4105CQ7 ATP-dependent helicase Astex_2984 ENOG4105CUB amino acid Astex_2985 ENOG4105C5X domain protein Astex_2987 ENOG4105CBX hi0933 family Astex_2989 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Astex_2990 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Astex_2995 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Astex_2996 ENOG4105C03 ribonuclease Astex_2997 ENOG4108K0D peptidase, M48 Astex_3000 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Astex_3001 ENOG4106A2Z transcriptional regulator antitoxin, MazE Astex_3004 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Astex_3005 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Astex_3006 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein Astex_3007 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Astex_3009 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) Astex_3012 ENOG4107RTZ reductase Astex_3015 ENOG4105C9M aspartyl-trna synthetase Astex_3020 ENOG4108V3E phosphoribosylglycinamide formyltransferase Astex_3021 ENOG4105CXB phosphoribosylaminoimidazole synthetase Astex_3022 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) Astex_3023 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Astex_3024 ENOG4105C5H ABC transporter Astex_3027 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Astex_3031 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) Astex_3032 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) Astex_3033 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Astex_3035 ENOG4105MP9 class II Aldolase Astex_3037 ENOG4107QX8 SPFH domain, Band 7 family protein Astex_3038 ENOG4108Z4K mutator MutT protein Astex_3039 ENOG4105CQB FAD linked oxidase domain protein Astex_3040 ENOG4105ETX regulatoR Astex_3041 ENOG4105D1Q UPF0246 protein Astex_3042 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Astex_3043 ENOG4105CPW cytochrome b561 Astex_3044 ENOG4105CSU acyl-Coa dehydrogenase Astex_3053 ENOG4105DZ1 carboxypeptidase Astex_3056 ENOG4107SKI cobyrinic Acid a,c-diamide synthase Astex_3057 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Astex_3058 ENOG4105W5Q DNA repair protein (RadC Astex_3059 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) Astex_3060 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) Astex_3062 ENOG4105E08 Glycoside hydrolase, family 9 Astex_3067 ENOG4107QPR SAICAR synthetase Astex_3068 ENOG4105VR9 phosphoribosylformylglycinamidine synthase Astex_3069 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Astex_3070 ENOG4108HGY Proline imino-peptidase Astex_3071 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii Astex_3075 ENOG4105M2J Glutaredoxin Astex_3077 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Astex_3080 ENOG4105C4W S-formylglutathione hydrolase Astex_3082 ENOG4107QPD alcohol dehydrogenase Astex_3083 ENOG4105C8Q Methyl-accepting chemotaxis Astex_3084 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Astex_3085 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Astex_3086 ENOG4105D3G Pseudouridine synthase Astex_3092 ENOG4108V06 Glutathione peroxidase Astex_3096 ENOG4105C2I pirin domain protein Astex_3099 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) Astex_3100 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Astex_3101 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Astex_3102 ENOG4108UUM single-stranded DNA-binding protein Astex_3105 ENOG4108T1X regulatory protein FlaEY Astex_3108 ENOG4107W75 Flagellin Astex_3109 ENOG4107W75 Flagellin Astex_3110 ENOG41060XD Flagellar protein FlaF Astex_3111 ENOG4105IE4 repressor protein FlbT Astex_3112 ENOG4105RQ9 TPR repeat-containing protein Astex_3114 ENOG4108R7K Metal Dependent Phosphohydrolase Astex_3116 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Astex_3119 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Astex_3120 ENOG4105C38 Glycyl-tRNA synthetase beta subunit Astex_3121 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit Astex_3124 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Astex_3126 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase Astex_3130 ENOG4107QS4 23S rRNA Astex_3136 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Astex_3140 ENOG4105C8Q Methyl-accepting chemotaxis Astex_3141 ENOG4105BZU Histidine kinase Astex_3142 ENOG4108UXN response regulator Astex_3146 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Astex_3147 ENOG4105EI2 Pseudouridine synthase Astex_3148 ENOG41085J0 Protein CrcB homolog Astex_3149 ENOG4105K59 histidine triad (HIT) protein Astex_3150 ENOG4105CVJ phosphoglycerate mutase Astex_3151 ENOG4105BZU Histidine kinase Astex_3154 ENOG4105DEN Luciferase family Astex_3155 ENOG4105D3Q Sugar transferase Astex_3166 ENOG4105RHA ABC transporter, permease Astex_3167 ENOG4108IUX (ABC) transporter Astex_3169 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Astex_3170 ENOG4108XG2 Histidine kinase Astex_3171 ENOG4105WH1 Two component transcriptional regulator luxr family Astex_3177 ENOG4105EPD Oligopeptide transporter, Opt family Astex_3178 ENOG4105D05 Receptor Astex_3180 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Astex_3181 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Astex_3186 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Astex_3188 ENOG4105DQ4 alcohol dehydrogenase Astex_3189 ENOG4105CXT aspartate transcarbamylase Astex_3191 ENOG4105CD3 dihydroorotase Astex_3192 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) Astex_3196 ENOG4108YYH Nadph-dependent fmn reductase Astex_3198 ENOG4108XC3 NADH ubiquinone oxidoreductase Astex_3203 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) Astex_3207 ENOG4105CNT hydrolase family 2 Astex_3211 ENOG4105E08 Glycoside hydrolase, family 9 Astex_3212 ENOG4108K2F hydrolase Family 5 Astex_3213 ENOG4105QV4 Tryptophan halogenase Astex_3220 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Astex_3221 ENOG4108MGY Histidine kinase Astex_3222 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Astex_3225 ENOG4105CNT hydrolase family 2 Astex_3227 ENOG4105KAF membrAne Astex_3234 ENOG4105E5H Transposase Astex_3239 ENOG4105C9K Endothelin-converting enzyme 1 Astex_3242 ENOG4105CUT histidyl-tRNA synthetase Astex_3244 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Astex_3245 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Astex_3246 ENOG4105CFH Aspartokinase Astex_3247 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Astex_3248 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) Astex_3252 ENOG4105VW4 glutaredoxin 3 Astex_3254 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Astex_3255 ENOG4105M6F mutator MutT protein Astex_3256 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Astex_3257 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase Astex_3258 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Astex_3263 ENOG4105E9Q Acyl-transferase Astex_3266 ENOG4105CAK Cell division ATP-binding protein ftsE Astex_3268 ENOG4108UGV hypoxanthine phosphoribosyltransferase Astex_3270 ENOG4105BZS acriflavin resistance protein Astex_3271 ENOG4105BZU Histidine kinase Astex_3273 ENOG4105BZU Histidine kinase Astex_3274 ENOG4108S3I UPF0259 membrane protein Astex_3278 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Astex_3282 ENOG4105BZU Histidine kinase Astex_3284 ENOG4107XAN XdhC and CoxI family Astex_3289 ENOG4108RXX maleylacetoacetate isomerase Astex_3291 ENOG4105BZU Histidine kinase Astex_3293 ENOG4105DPW Major facilitator superfamily MFS_1 Astex_3294 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) Astex_3295 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase Astex_3296 ENOG4105F1J Homogentisate 1,2-dioxygenase Astex_3299 ENOG4105CGF Aromatic amino acid aminotransferase Astex_3300 ENOG4105QJH Domain of unknown function (DUF718) Astex_3301 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Astex_3303 ENOG4105D44 asparaginase Astex_3304 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) Astex_3306 ENOG4105QV4 Tryptophan halogenase Astex_3307 ENOG4105QV4 Tryptophan halogenase Astex_3309 ENOG4105QV4 Tryptophan halogenase Astex_3316 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) Astex_3317 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) Astex_3320 ENOG4105CYP glycoside hydrolase, family Astex_3321 ENOG4107SDU Methyl-accepting chemotaxis Astex_3325 ENOG4108UXN response regulator Astex_3326 ENOG4105QV4 Tryptophan halogenase Astex_3332 ENOG4105D01 (LipO)protein Astex_3333 ENOG4108UMI ABC transporter, permease Astex_3334 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Astex_3338 ENOG4105CXK mandelate racemase muconate lactonizing Astex_3339 ENOG4105D0H Alpha-glucuronidase (EC 3.2.1.139) Astex_3346 ENOG4105CT4 transporter Astex_3347 ENOG4105ETE Transcriptional regulator (LacI family Astex_3350 ENOG4105D05 Receptor Astex_3364 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Astex_3368 ENOG4105ETE Transcriptional regulator (LacI family Astex_3369 ENOG4105CHR reductase Astex_3370 ENOG4105DMF Dehydrogenase Astex_3372 ENOG4105E2Z phosphate ABC transporter (Permease Astex_3373 ENOG4105C8U phosphate abc transporter Astex_3374 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) Astex_3376 ENOG41067SE Tetr family transcriptional regulator Astex_3377 ENOG4105C1P efflux transporter, rnd family, mfp subunit Astex_3378 ENOG4105BZS acriflavin resistance protein Astex_3379 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Astex_3382 ENOG4105QV4 Tryptophan halogenase Astex_3387 ENOG4108YXV Transcriptional regulator Astex_3397 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Astex_3398 ENOG4107QMZ Dehydrogenase Astex_3399 ENOG4105DC7 peptidase M24 Astex_3400 ENOG4105CNT hydrolase family 2 Astex_3401 ENOG4105ETE Transcriptional regulator (LacI family Astex_3403 ENOG4105EBR Carboxylesterase Astex_3410 ENOG4105BZU Histidine kinase Astex_3413 ENOG4105C19 ABC transporter Astex_3414 ENOG4107RBB ABC transporter, permease Astex_3415 ENOG4105DPW Major facilitator superfamily MFS_1 Astex_3418 ENOG4105CPQ Dehydrogenase Astex_3420 ENOG4105NBR Pectinesterase Astex_3429 ENOG4107ZSV Receptor Astex_3430 ENOG4108XEP Alpha Beta Hydrolase Fold protein Astex_3431 ENOG4108R86 Transcriptional regulator Astex_3434 ENOG4107SDU Methyl-accepting chemotaxis Astex_3439 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) Astex_3446 ENOG4105CGZ zinc metallopeptidase Astex_3447 ENOG4105YIP Tetr family transcriptional regulator Astex_3448 ENOG4105ENT Efflux transporter rnd family, mfp subunit Astex_3451 ENOG4105D49 3-dehydroquinate synthase Astex_3452 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Astex_3453 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Astex_3454 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) Astex_3458 ENOG4105D64 Mechanosensitive ion channel Astex_3460 ENOG4108Z6B deaminase Astex_3461 ENOG4105FE9 pseudouridine synthase Astex_3462 ENOG4106H78 methyltransferase Astex_3464 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Astex_3466 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Astex_3467 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Astex_3469 ENOG4108RG0 uracil-dna glycosylase Astex_3471 ENOG4105FE9 pseudouridine synthase Astex_3472 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Astex_3477 ENOG4108SF5 RNA Polymerase Astex_3481 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Astex_3482 ENOG4105DVC DnaJ domain protein Astex_3483 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) Astex_3488 ENOG4108KPZ tonB-dependent Receptor Astex_3489 ENOG4105W0E 50S ribosomal protein L33 Astex_3490 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Astex_3492 ENOG4105DTN riboflavin biosynthesis protein ribF Astex_3494 ENOG4108VYJ response regulator receiver protein Astex_3495 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) Astex_3502 ENOG4108M8H domain protein Astex_3503 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) Astex_3507 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Astex_3511 ENOG4105C12 Phosphoribosylglycinamide synthetase Astex_3513 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) Astex_3516 ENOG4105BZ1 (ABC) transporter Astex_3520 ENOG4105ECY inositol monophosphatase Astex_3521 ENOG4105CMS peptidase U62, modulator of DNA gyrase Astex_3522 ENOG4105BZU Histidine kinase Astex_3526 ENOG4105G6Z alkaline phosphatase Astex_3527 ENOG4108QDE fad dependent oxidoreductase Astex_3528 ENOG4105CVP deoxyribo-dipyrimidine photolyase Astex_3532 ENOG4105C8Q Methyl-accepting chemotaxis Astex_3537 ENOG4105ETE Transcriptional regulator (LacI family Astex_3538 ENOG4105DDI hemolysin-type calcium-binding region Astex_3541 ENOG4105MH3 Protein of unknown function (DUF2490) Astex_3544 ENOG4105WH1 Two component transcriptional regulator luxr family Astex_3546 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family Astex_3550 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) Astex_3551 ENOG4105DPW Major facilitator superfamily MFS_1 Astex_3561 ENOG4107HP6 Transcriptional regulator Astex_3562 ENOG4105ERH Fumarylacetoacetate hydrolase Astex_3566 ENOG4105CIS alcohol dehydrogenase Astex_3570 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB Astex_3572 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) Astex_3573 ENOG4105DH8 myo-inositol catabolism Astex_3575 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) Astex_3576 ENOG4105D7K pfkb domain protein Astex_3579 ENOG4105CWX Alpha-1,2-mannosidase Astex_3580 ENOG4105CNN ABC, transporter Astex_3582 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator Astex_3583 ENOG4105C26 Dehydrogenase Astex_3584 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) Astex_3585 ENOG4105CCU oxidase (Subunit III) Astex_3586 ENOG4105BZ9 Cytochrome C oxidase, subunit I Astex_3587 ENOG4105E2S oxidase) subunit II Astex_3592 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) Astex_3600 ENOG4105CNT hydrolase family 2 Astex_3604 ENOG4105CNT hydrolase family 2 Astex_3612 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) Astex_3613 ENOG4106Z5D Glycoside Hydrolase Family 43 Astex_3614 ENOG4105CNT hydrolase family 2 Astex_3615 ENOG4105RD7 BadF BadG BcrA BcrD Astex_3619 ENOG4105QV4 Tryptophan halogenase Astex_3621 ENOG4105C6F GntR Family Transcriptional Regulator Astex_3622 ENOG4105C6F GntR Family Transcriptional Regulator Astex_3625 ENOG4105CHP RNA polymerase Astex_3626 ENOG4105CGS Alpha-glucosidase Astex_3630 ENOG4105HEI LysR family (Transcriptional regulator Astex_3632 ENOG4107R6D beta-lactam binding protein AmpH Astex_3639 ENOG4105C8Q Methyl-accepting chemotaxis Astex_3646 ENOG4105MRR Transcriptional regulator (By similarity) Astex_3648 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Astex_3655 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A Astex_3656 ENOG4105VGJ Virulence-associated protein Astex_3660 ENOG4108IG5 Transcriptional regulator Astex_3662 ENOG4105BZS acriflavin resistance protein Astex_3663 ENOG4105ENJ RND efflux system, outer membrane lipoprotein Astex_3664 ENOG4105E1F short-chain dehydrogenase reductase Astex_3668 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase Astex_3670 ENOG4105DJB Major Facilitator Superfamily Astex_3674 ENOG4107RSM transcriptional regulator Astex_3675 ENOG4105D05 Receptor Astex_3676 ENOG4105H9W Short-chain dehydrogenase reductase Sdr Astex_3677 ENOG4105CXK mandelate racemase muconate lactonizing Astex_3680 ENOG4106032 Glutathionylspermidine synthase Astex_3684 ENOG4105CHR reductase Astex_3685 ENOG4105CKB glycosidase Astex_3687 ENOG4108Z9Z response to DNA damage stimulus Astex_3697 ENOG4105E18 UPF0276 protein Astex_3700 ENOG4105E18 UPF0276 protein Astex_3702 ENOG4105NCT RNA Polymerase Astex_3705 ENOG4105C4W S-formylglutathione hydrolase Astex_3720 ENOG4107QHF type ii secretion system protein e Astex_3722 ENOG4108VAU general secretion pathway protein G Astex_3744 ENOG4105D5G Transposase Astex_3759 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Astex_3805 ENOG4108YXV Transcriptional regulator Astex_3806 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Astex_3807 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) Astex_3809 ENOG4105C3J Cysteine desulfurase Astex_3818 ENOG4108A65 Transcriptional regulator Astex_3820 ENOG4105D6J arsenicaL-resistance protein Astex_3821 ENOG4105CAU Arsenical resistance protein, ArsH Astex_3822 ENOG4107WAU Protein tyrosine phosphatase Astex_3827 ENOG4105C59 p-type ATPase Astex_3842 ENOG4108IJF Heavy metal efflux pump, CzcA Astex_3847 ENOG4105VPX protein, conserved in bacteria Astex_3848 ENOG4105C59 p-type ATPase Astex_3852 ENOG4105C59 p-type ATPase