locus-tag	class	description
Astex_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Astex_0002	COG0592	DNA-directed DNA polymerase activity
Astex_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Astex_0004	COG0187	DNA topoisomerase II activity
Astex_0006	COG4948	Mandelate Racemase Muconate Lactonizing
Astex_0007	COG0137	argininosuccinate synthase activity
Astex_0009	COG3158	transport of potassium into the cell
Astex_0010	COG1959	2 iron, 2 sulfur cluster binding
Astex_0011	COG4221	oxidoreductase activity
Astex_0012	COG2095	MarC family integral membrane protein
Astex_0013	COG0284	orotidine-5'-phosphate decarboxylase activity
Astex_0014	COG5508	conserved small protein
Astex_0015	COG0501	Belongs to the peptidase M48B family
Astex_0017	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Astex_0019	COG0138	bifunctional purine biosynthesis protein purh
Astex_0023	COG0180	Tryptophanyl-tRNA synthetase
Astex_0024	COG0728	peptidoglycan biosynthetic process
Astex_0029	COG1487	ribonuclease activity
Astex_0034	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Astex_0035	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Astex_0036	COG0280	phosphate acetyltransferase
Astex_0036	COG0281	malic enzyme
Astex_0037	COG2807	transmembrane transport
Astex_0038	COG2205	protein histidine kinase activity
Astex_0038	COG5002	protein histidine kinase activity
Astex_0038	COG0784	Response regulator, receiver
Astex_0040	COG1538	Outer membrane efflux protein
Astex_0041	COG1136	(ABC) transporter
Astex_0041	COG0577	efflux transmembrane transporter activity
Astex_0042	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Astex_0043	COG0189	ligase activity
Astex_0044	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Astex_0046	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Astex_0047	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Astex_0049	COG3655	Transcriptional regulator
Astex_0050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Astex_0054	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Astex_0055	COG0412	Dienelactone hydrolase
Astex_0056	COG0443	Heat shock 70 kDa protein
Astex_0057	COG0484	heat shock protein binding
Astex_0058	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Astex_0060	COG0756	dUTP diphosphatase activity
Astex_0063	COG5001	Diguanylate cyclase
Astex_0064	COG0598	Magnesium transport protein CorA
Astex_0065	COG0840	transmembrane signaling receptor activity
Astex_0065	COG2972	Histidine kinase
Astex_0066	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Astex_0067	COG2226	methyltransferase
Astex_0079	COG0802	atpase or kinase
Astex_0080	COG3178	'Phosphotransferase
Astex_0081	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Astex_0083	COG1074	ATP-dependent DNA helicase activity
Astex_0086	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Astex_0088	COG3047	cAMP biosynthetic process
Astex_0090	COG1674	ftsk spoiiie
Astex_0091	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Astex_0092	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Astex_0099	COG1940	carbohydrate kinase activity
Astex_0099	COG1846	Transcriptional regulator
Astex_0103	COG0583	DNA-binding transcription factor activity
Astex_0106	COG1695	Transcriptional regulator
Astex_0109	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Astex_0110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Astex_0111	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Astex_0114	COG0071	Belongs to the small heat shock protein (HSP20) family
Astex_0115	COG0427	acetyl-CoA hydrolase
Astex_0116	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Astex_0117	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Astex_0118	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Astex_0119	COG1137	ATPase activity
Astex_0122	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Astex_0123	COG0477	Major facilitator Superfamily
Astex_0128	COG0745	RESPONSE REGULATOR receiver
Astex_0134	COG0495	leucyl-tRNA aminoacylation
Astex_0137	COG1475	DNA binding
Astex_0138	COG1192	Involved in chromosome partitioning
Astex_0139	COG0357	Ribosomal RNA small subunit methyltransferase G
Astex_0140	COG0445	tRNA wobble uridine modification
Astex_0141	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Astex_0143	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Astex_0145	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Astex_0146	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Astex_0148	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Astex_0149	COG0424	maF-like protein
Astex_0150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Astex_0151	COG0237	dephospho-CoA kinase activity
Astex_0152	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Astex_0153	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Astex_0155	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Astex_0158	COG0433	COG0433 Predicted ATPase
Astex_0161	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Astex_0166	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Astex_0167	COG1702	phosphate starvation-inducible protein PhoH
Astex_0168	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Astex_0169	COG1253	flavin adenine dinucleotide binding
Astex_0170	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Astex_0171	COG1396	sequence-specific DNA binding
Astex_0172	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Astex_0173	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Astex_0175	COG0779	Required for maturation of 30S ribosomal subunits
Astex_0178	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Astex_0178	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Astex_0184	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Astex_0185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Astex_0186	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Astex_0187	COG1185	polyribonucleotide nucleotidyltransferase activity
Astex_0190	COG2133	pyrroloquinoline quinone binding
Astex_0191	COG0335	large ribosomal subunit rRNA binding
Astex_0192	COG0336	Belongs to the RNA methyltransferase TrmD family
Astex_0193	COG4771	TonB-dependent receptor
Astex_0194	COG0745	RESPONSE REGULATOR receiver
Astex_0195	COG2373	Large extracellular alpha-helical protein
Astex_0196	COG4953	penicillin-binding protein 1C
Astex_0197	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Astex_0199	COG0228	four-way junction DNA binding
Astex_0200	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Astex_0203	COG0436	Aminotransferase
Astex_0205	COG0039	L-malate dehydrogenase activity
Astex_0208	COG2009	succinate dehydrogenase
Astex_0210	COG1053	succinate dehydrogenase
Astex_0211	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Astex_0212	COG0633	Ferredoxin
Astex_0213	COG2239	Acts as a magnesium transporter
Astex_0215	COG2205	protein histidine kinase activity
Astex_0217	COG0640	Transcriptional regulator
Astex_0219	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Astex_0221	COG1999	signal sequence binding
Astex_0222	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
Astex_0230	COG2353	YceI-like domain
Astex_0234	COG2814	Major facilitator Superfamily
Astex_0235	COG0045	succinate-CoA ligase (ADP-forming) activity
Astex_0236	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Astex_0242	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Astex_0246	COG1749	Flagellar hook protein flgE
Astex_0255	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Astex_0259	COG1253	flavin adenine dinucleotide binding
Astex_0260	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Astex_0261	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Astex_0262	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Astex_0263	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Astex_0264	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Astex_0265	COG0840	transmembrane signaling receptor activity
Astex_0267	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Astex_0268	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Astex_0269	COG0552	protein localization to endoplasmic reticulum
Astex_0270	COG2917	probably involved in intracellular septation
Astex_0273	COG1028	Short-chain dehydrogenase reductase Sdr
Astex_0274	COG3639	organic phosphonate transmembrane transporter activity
Astex_0275	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Astex_0276	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Astex_0281	COG1899	peptidyl-lysine modification to peptidyl-hypusine
Astex_0282	COG0657	acetylesterase activity
Astex_0282	COG2755	lipolytic protein G-D-S-L family
Astex_0284	COG1309	transcriptional regulator
Astex_0287	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Astex_0290	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Astex_0291	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Astex_0292	COG5507	3-demethylubiquinone-9 3-methyltransferase
Astex_0293	COG5507	3-demethylubiquinone-9 3-methyltransferase
Astex_0294	COG1051	belongs to the nudix hydrolase family
Astex_0308	COG0629	single-stranded DNA binding
Astex_0311	COG3750	Belongs to the UPF0335 family
Astex_0329	COG4695	Portal protein
Astex_0330	COG0740	serine-type endopeptidase activity
Astex_0359	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Astex_0364	COG2124	cytochrome p450
Astex_0366	COG2205	protein histidine kinase activity
Astex_0367	COG3401	FG-GAP repeat protein
Astex_0373	COG2801	Transposase and inactivated derivatives
Astex_0374	COG0670	Belongs to the BI1 family
Astex_0375	COG2301	Belongs to the HpcH HpaI aldolase family
Astex_0377	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Astex_0379	COG0745	RESPONSE REGULATOR receiver
Astex_0380	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Astex_0385	COG1073	alpha beta
Astex_0387	COG0303	'Molybdopterin
Astex_0388	COG0521	Mo-molybdopterin cofactor biosynthetic process
Astex_0389	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Astex_0390	COG2272	Belongs to the type-B carboxylesterase lipase family
Astex_0394	COG2186	Transcriptional regulator
Astex_0397	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Astex_0399	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Astex_0400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Astex_0403	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Astex_0404	COG0523	cobalamin synthesis protein
Astex_0406	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Astex_0408	COG1671	Belongs to the UPF0178 family
Astex_0411	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Astex_0412	COG2885	chlorophyll binding
Astex_0414	COG1086	Polysaccharide biosynthesis protein
Astex_0415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Astex_0416	COG2089	acid synthase
Astex_0423	COG4964	Belongs to the GSP D family
Astex_0432	COG0793	Belongs to the peptidase S41A family
Astex_0436	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Astex_0439	COG1605	Chorismate mutase
Astex_0439	COG0077	Prephenate dehydratase
Astex_0442	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Astex_0443	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Astex_0444	COG4133	protoheme IX ABC transporter activity
Astex_0445	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Astex_0450	COG1904	glucuronate isomerase
Astex_0451	COG1609	Transcriptional regulator
Astex_0452	COG2721	sulfolactate sulfo-lyase activity
Astex_0453	COG0246	Mannitol dehydrogenase
Astex_0454	COG1396	sequence-specific DNA binding
Astex_0454	COG3800	Transcriptional regulator
Astex_0457	COG2224	Isocitrate lyase
Astex_0461	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Astex_0461	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Astex_0465	COG0840	transmembrane signaling receptor activity
Astex_0468	COG0745	RESPONSE REGULATOR receiver
Astex_0469	COG2205	protein histidine kinase activity
Astex_0470	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Astex_0471	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Astex_0471	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Astex_0472	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Astex_0472	COG2169	Transcriptional regulator
Astex_0477	COG0121	glutamine amidotransferase
Astex_0478	COG1764	response to oxidative stress
Astex_0484	COG0730	response to heat
Astex_0487	COG1199	ATP-dependent helicase activity
Astex_0488	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Astex_0491	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Astex_0493	COG1309	transcriptional regulator
Astex_0499	COG1250	3-hydroxyacyl-CoA dehydrogenase
Astex_0501	COG2311	Membrane
Astex_0502	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Astex_0503	COG0165	Argininosuccinate lyase
Astex_0505	COG0019	diaminopimelate decarboxylase activity
Astex_0509	COG0840	transmembrane signaling receptor activity
Astex_0510	COG2967	ApaG domain
Astex_0511	COG0717	Belongs to the dCTP deaminase family
Astex_0520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Astex_0521	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Astex_0522	COG0612	Peptidase, M16
Astex_0524	COG1462	curli production assembly transport component CsgG
Astex_0532	COG2184	nucleotidyltransferase activity
Astex_0534	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Astex_0541	COG3540	Alkaline phosphatase
Astex_0543	COG1737	Transcriptional regulator
Astex_0545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Astex_0552	COG1335	isochorismatase
Astex_0555	COG4566	intracellular signal transduction
Astex_0556	COG4191	Histidine kinase
Astex_0557	COG4566	intracellular signal transduction
Astex_0573	COG0745	RESPONSE REGULATOR receiver
Astex_0580	COG0438	transferase activity, transferring glycosyl groups
Astex_0581	COG1522	sequence-specific DNA binding
Astex_0585	COG0482	sulfurtransferase activity
Astex_0589	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Astex_0590	COG1749	Flagellar hook protein flgE
Astex_0592	COG1766	The M ring may be actively involved in energy transduction
Astex_0593	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Astex_0596	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Astex_0597	COG2204	response regulator
Astex_0599	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Astex_0604	COG1157	protein secretion by the type III secretion system
Astex_0608	COG0745	RESPONSE REGULATOR receiver
Astex_0613	COG2201	protein-glutamate methylesterase activity
Astex_0616	COG2198	Histidine kinase
Astex_0616	COG0643	Histidine kinase
Astex_0621	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Astex_0623	COG2166	iron-sulfur cluster assembly
Astex_0624	COG2205	protein histidine kinase activity
Astex_0624	COG2202	Pas domain
Astex_0625	COG2205	protein histidine kinase activity
Astex_0629	COG2814	Major facilitator Superfamily
Astex_0630	COG1272	protein, Hemolysin III
Astex_0631	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Astex_0638	COG3273	potassium ion transport
Astex_0638	COG0471	metal ion transport
Astex_0639	COG0746	molybdenum cofactor guanylyltransferase activity
Astex_0643	COG2271	Major facilitator Superfamily
Astex_0644	COG3507	Belongs to the glycosyl hydrolase 43 family
Astex_0650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Astex_0651	COG0446	pyridine nucleotide-disulphide oxidoreductase
Astex_0654	COG0745	RESPONSE REGULATOR receiver
Astex_0655	COG2205	protein histidine kinase activity
Astex_0656	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Astex_0657	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Astex_0658	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Astex_0664	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Astex_0665	COG3577	Aspartyl protease
Astex_0671	COG0556	nucleotide-excision repair
Astex_0676	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Astex_0678	COG0492	ferredoxin-NADP+ reductase activity
Astex_0680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Astex_0684	COG0640	Transcriptional regulator
Astex_0686	COG2154	pterin-4-alpha-carbinolamine dehydratase
Astex_0687	COG3186	Phenylalanine-4-hydroxylase
Astex_0692	COG2205	protein histidine kinase activity
Astex_0694	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Astex_0698	COG0018	arginyl-trna synthetase
Astex_0699	COG3634	alkyl hydroperoxide reductase activity
Astex_0700	COG0450	alkyl hydroperoxide reductase
Astex_0706	COG1872	DUF167
Astex_0707	COG0473	3-isopropylmalate dehydrogenase activity
Astex_0708	COG0066	3-isopropylmalate dehydratase activity
Astex_0709	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Astex_0710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Astex_0711	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Astex_0714	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Astex_0717	COG0129	dihydroxy-acid dehydratase activity
Astex_0722	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Astex_0723	COG3162	membrane
Astex_0727	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Astex_0728	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Astex_0729	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Astex_0730	COG0714	Associated with various cellular activities
Astex_0734	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Astex_0735	COG1690	Belongs to the RtcB family
Astex_0740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Astex_0745	COG0181	hydroxymethylbilane synthase activity
Astex_0746	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Astex_0747	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Astex_0750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Astex_0756	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Astex_0759	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Astex_0761	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Astex_0764	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Astex_0768	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Astex_0772	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Astex_0776	COG4067	protein conserved in archaea
Astex_0776	COG0189	ligase activity
Astex_0781	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Astex_0783	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Astex_0786	COG1073	alpha beta
Astex_0788	COG3384	dioxygenase
Astex_0789	COG2353	YceI-like domain
Astex_0790	COG4771	TonB-dependent receptor
Astex_0798	COG0625	glutathione transferase activity
Astex_0799	COG0442	prolyl-tRNA aminoacylation
Astex_0802	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Astex_0803	COG0385	Bile acid
Astex_0806	COG4948	Mandelate Racemase Muconate Lactonizing
Astex_0813	COG0107	imidazoleglycerol-phosphate synthase activity
Astex_0815	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Astex_0818	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Astex_0821	COG0443	Heat shock 70 kDa protein
Astex_0824	COG1176	ABC-type spermidine putrescine transport system, permease component I
Astex_0825	COG1177	transmembrane transport
Astex_0826	COG3842	ATPase activity
Astex_0828	COG0114	fumarate hydratase activity
Astex_0831	COG2076	Multidrug Resistance protein
Astex_0833	COG1132	(ABC) transporter
Astex_0837	COG0463	Glycosyl transferase, family 2
Astex_0840	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
Astex_0842	COG1028	Short-chain dehydrogenase reductase Sdr
Astex_0844	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Astex_0847	COG0167	dihydroorotate dehydrogenase activity
Astex_0849	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Astex_0850	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
Astex_0851	COG4786	Flagellar basal body rod
Astex_0852	COG4786	Flagellar basal body rod
Astex_0854	COG1136	(ABC) transporter
Astex_0858	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Astex_0860	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Astex_0861	COG0783	Belongs to the Dps family
Astex_0864	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Astex_0868	COG2201	protein-glutamate methylesterase activity
Astex_0873	COG2885	chlorophyll binding
Astex_0874	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Astex_0876	COG2957	Belongs to the agmatine deiminase family
Astex_0879	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Astex_0880	COG0840	transmembrane signaling receptor activity
Astex_0884	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Astex_0885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Astex_0888	COG1322	Protein conserved in bacteria
Astex_0891	COG0242	peptide deformylase activity
Astex_0892	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Astex_0893	COG0101	tRNA pseudouridine synthase activity
Astex_0894	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Astex_0900	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Astex_0900	COG2755	lipolytic protein G-D-S-L family
Astex_0902	COG0598	Magnesium transport protein CorA
Astex_0905	COG4206	TonB-dependent receptor
Astex_0910	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Astex_0912	COG5001	Diguanylate cyclase
Astex_0914	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Astex_0917	COG0588	phosphoglycerate mutase activity
Astex_0921	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Astex_0924	COG1294	oxidase, subunit
Astex_0926	COG1086	Polysaccharide biosynthesis protein
Astex_0928	COG0314	molybdopterin synthase activity
Astex_0929	COG0315	cyclic pyranopterin monophosphate synthase activity
Astex_0930	COG2264	protein methyltransferase activity
Astex_0932	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Astex_0938	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Astex_0939	COG0049	tRNA binding
Astex_0940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Astex_0941	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Astex_0944	COG0051	transcription antitermination factor activity, RNA binding
Astex_0945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Astex_0946	COG0088	Forms part of the polypeptide exit tunnel
Astex_0947	COG0089	rRNA binding
Astex_0948	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Astex_0949	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Astex_0950	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Astex_0951	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Astex_0952	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Astex_0953	COG0255	Belongs to the universal ribosomal protein uL29 family
Astex_0954	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Astex_0955	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Astex_0956	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Astex_0957	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Astex_0958	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Astex_0959	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Astex_0960	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Astex_0961	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Astex_0962	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Astex_0963	COG1841	ribosomal large subunit assembly
Astex_0964	COG0200	Binds to the 23S rRNA
Astex_0965	COG0201	protein transport
Astex_0966	COG0563	adenylate kinase activity
Astex_0967	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Astex_0968	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Astex_0969	COG0202	RNA polymerase activity
Astex_0970	COG0203	ribosomal protein L17
Astex_0976	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Astex_0978	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
Astex_0985	COG1956	GAF domain-containing protein
Astex_0988	COG0823	Involved in the tonB-independent uptake of proteins
Astex_0988	COG1506	peptidase
Astex_0990	COG2066	Belongs to the glutaminase family
Astex_0992	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Astex_0993	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Astex_0994	COG4771	TonB-dependent receptor
Astex_0997	COG0318	PFAM AMP-dependent synthetase and ligase
Astex_1001	COG3237	CsbD-like
Astex_1005	COG1028	Short-chain dehydrogenase reductase Sdr
Astex_1007	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Astex_1011	COG1994	Peptidase M50
Astex_1012	COG0840	transmembrane signaling receptor activity
Astex_1014	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Astex_1015	COG0174	glutamine synthetase
Astex_1018	COG3345	alpha-galactosidase
Astex_1020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Astex_1023	COG2079	MmgE PrpD family protein
Astex_1030	COG1136	(ABC) transporter
Astex_1031	COG0523	cobalamin synthesis protein
Astex_1033	COG3540	Alkaline phosphatase
Astex_1042	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Astex_1045	COG1858	cytochrome C peroxidase
Astex_1055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Astex_1057	COG0431	NADPH-dependent FMN reductase
Astex_1066	COG1595	DNA-templated transcription, initiation
Astex_1071	COG0494	nUDIX hydrolase
Astex_1073	COG0702	epimerase
Astex_1074	COG1733	regulation of RNA biosynthetic process
Astex_1075	COG0800	Aldolase
Astex_1076	COG3734	2-keto-3-deoxy-galactonokinase
Astex_1077	COG3386	PFAM SMP-30 Gluconolaconase
Astex_1078	COG0183	Belongs to the thiolase family
Astex_1079	COG1250	3-hydroxyacyl-CoA dehydrogenase
Astex_1079	COG1024	Enoyl-CoA hydratase
Astex_1080	COG0400	carboxylic ester hydrolase activity
Astex_1089	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Astex_1090	COG0753	catalase activity
Astex_1094	COG0387	Pfam Sodium calcium exchanger
Astex_1096	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Astex_1105	COG0670	Belongs to the BI1 family
Astex_1107	COG2205	protein histidine kinase activity
Astex_1111	COG2239	Acts as a magnesium transporter
Astex_1113	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Astex_1114	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Astex_1116	COG0356	it plays a direct role in the translocation of protons across the membrane
Astex_1121	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Astex_1123	COG1194	a g-specific adenine glycosylase
Astex_1126	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Astex_1127	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Astex_1128	COG3152	Membrane
Astex_1129	COG3152	Membrane
Astex_1130	COG0354	folic acid binding
Astex_1132	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Astex_1134	COG1024	Enoyl-CoA hydratase
Astex_1137	COG0617	tRNA 3'-terminal CCA addition
Astex_1139	COG0408	coproporphyrinogen oxidase activity
Astex_1140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Astex_1141	COG0723	plastoquinol--plastocyanin reductase activity
Astex_1143	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Astex_1143	COG2857	Cytochrome c1
Astex_1144	COG1418	mRNA catabolic process
Astex_1146	COG0012	GTP binding
Astex_1148	COG1819	glycosyl
Astex_1149	COG0193	aminoacyl-tRNA hydrolase activity
Astex_1150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Astex_1152	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Astex_1156	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Astex_1163	COG1846	Transcriptional regulator
Astex_1164	COG1764	response to oxidative stress
Astex_1165	COG0667	Aldo Keto reductase
Astex_1167	COG0626	cystathionine gamma-synthase activity
Astex_1172	COG0460	homoserine dehydrogenase
Astex_1173	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Astex_1177	COG0564	pseudouridine synthase activity
Astex_1180	COG3152	Membrane
Astex_1182	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Astex_1185	COG0393	Putative heavy-metal-binding
Astex_1189	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Astex_1191	COG5328	Belongs to the UPF0262 family
Astex_1193	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Astex_1194	COG0424	maF-like protein
Astex_1196	COG0459	protein refolding
Astex_1197	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Astex_1204	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Astex_1208	COG0714	Associated with various cellular activities
Astex_1213	COG4191	Histidine kinase
Astex_1213	COG0784	Response regulator, receiver
Astex_1214	COG1609	Transcriptional regulator
Astex_1220	COG2211	Major facilitator Superfamily
Astex_1221	COG1462	curli production assembly transport component CsgG
Astex_1222	COG1462	curli production assembly transport component CsgG
Astex_1225	COG3250	beta-galactosidase activity
Astex_1226	COG3250	beta-galactosidase activity
Astex_1233	COG0531	amino acid
Astex_1234	COG1116	anion transmembrane transporter activity
Astex_1235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Astex_1236	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Astex_1243	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Astex_1246	COG3338	carbonate dehydratase activity
Astex_1247	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Astex_1251	COG1706	bacterial-type flagellum-dependent cell motility
Astex_1253	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Astex_1258	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Astex_1260	COG0616	signal peptide processing
Astex_1266	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Astex_1268	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Astex_1269	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Astex_1270	COG0454	-acetyltransferase
Astex_1272	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Astex_1273	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Astex_1274	COG1522	sequence-specific DNA binding
Astex_1278	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Astex_1279	COG1309	transcriptional regulator
Astex_1281	COG0673	inositol 2-dehydrogenase activity
Astex_1291	COG3128	pkhd-type hydroxylase
Astex_1295	COG1477	protein flavinylation
Astex_1298	COG3046	protein related to deoxyribodipyrimidine photolyase
Astex_1301	COG4771	TonB-dependent receptor
Astex_1302	COG0457	Tetratricopeptide repeat
Astex_1306	COG0657	acetylesterase activity
Astex_1306	COG2755	lipolytic protein G-D-S-L family
Astex_1311	COG3459	Glycosyltransferase 36 associated
Astex_1312	COG3682	Transcriptional regulator
Astex_1318	COG0726	polysaccharide deacetylase
Astex_1320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Astex_1325	COG0667	Aldo Keto reductase
Astex_1326	COG1473	amidohydrolase
Astex_1327	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Astex_1329	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
Astex_1333	COG3451	type IV secretory pathway VirB4
Astex_1336	COG0741	lytic transglycosylase activity
Astex_1340	COG2132	Multicopper oxidase
Astex_1343	COG1609	Transcriptional regulator
Astex_1344	COG0477	Major facilitator Superfamily
Astex_1346	COG2205	protein histidine kinase activity
Astex_1346	COG0784	Response regulator, receiver
Astex_1349	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Astex_1350	COG0805	protein transport
Astex_1351	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Astex_1352	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Astex_1353	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Astex_1354	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Astex_1355	COG1472	Belongs to the glycosyl hydrolase 3 family
Astex_1359	COG1793	dna ligase
Astex_1360	COG1793	dna ligase
Astex_1360	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Astex_1361	COG1201	RNA secondary structure unwinding
Astex_1364	COG0583	DNA-binding transcription factor activity
Astex_1371	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Astex_1375	COG3867	Arabinogalactan endo-beta-1,4-galactanase
Astex_1384	COG2755	lipolytic protein G-D-S-L family
Astex_1390	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Astex_1392	COG0321	lipoyl(octanoyl) transferase activity
Astex_1395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Astex_1396	COG1278	Cold shock
Astex_1398	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Astex_1401	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Astex_1402	COG0142	geranyltranstransferase activity
Astex_1403	COG1722	exodeoxyribonuclease VII activity
Astex_1405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Astex_1408	COG1595	DNA-templated transcription, initiation
Astex_1411	COG1501	Belongs to the glycosyl hydrolase 31 family
Astex_1413	COG2186	Transcriptional regulator
Astex_1416	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Astex_1417	COG1684	flagellar biosynthetic protein fliR
Astex_1418	COG1987	bacterial-type flagellum assembly
Astex_1419	COG1677	Flagellar hook-basal body complex protein FliE
Astex_1420	COG1558	bacterial-type flagellum-dependent cell motility
Astex_1422	COG3190	flagellar
Astex_1423	COG1338	Plays a role in the flagellum-specific transport system
Astex_1426	COG3609	addiction module antidote protein, CC2985 family
Astex_1438	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Astex_1441	COG0842	Transport permease protein
Astex_1443	COG1131	(ABC) transporter
Astex_1445	COG1309	transcriptional regulator
Astex_1448	COG2267	carboxylic ester hydrolase activity
Astex_1452	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Astex_1457	COG2824	Alkylphosphonate utilization operon protein PhnA
Astex_1459	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Astex_1462	COG2205	protein histidine kinase activity
Astex_1462	COG2198	Histidine kinase
Astex_1462	COG0784	Response regulator, receiver
Astex_1463	COG4206	TonB-dependent receptor
Astex_1467	COG1309	transcriptional regulator
Astex_1472	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Astex_1481	COG3727	T/G mismatch-specific endonuclease activity
Astex_1493	COG1058	Belongs to the CinA family
Astex_1493	COG1546	Belongs to the CinA family
Astex_1494	COG1489	DNA binding
Astex_1495	COG0392	lysyltransferase activity
Astex_1495	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Astex_1497	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Astex_1508	COG1742	UPF0060 membrane protein
Astex_1509	COG0534	Mate efflux family protein
Astex_1512	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Astex_1515	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Astex_1516	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Astex_1517	COG0546	phosphoglycolate phosphatase activity
Astex_1518	COG0475	glutathione-regulated potassium exporter activity
Astex_1518	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Astex_1520	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Astex_1526	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Astex_1531	COG0642	Histidine kinase
Astex_1534	COG2022	thiamine diphosphate biosynthetic process
Astex_1534	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Astex_1539	COG0848	biopolymer transport protein
Astex_1541	COG2951	lytic endotransglycosylase activity
Astex_1545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Astex_1546	COG3750	Belongs to the UPF0335 family
Astex_1549	COG2204	response regulator
Astex_1554	COG3739	integral membrane protein
Astex_1555	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Astex_1556	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Astex_1557	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Astex_1558	COG2801	Transposase and inactivated derivatives
Astex_1561	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Astex_1561	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Astex_1562	COG0509	glycine decarboxylation via glycine cleavage system
Astex_1563	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Astex_1567	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Astex_1568	COG0328	RNA-DNA hybrid ribonuclease activity
Astex_1572	COG1702	phosphate starvation-inducible protein PhoH
Astex_1577	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Astex_1579	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Astex_1580	COG0745	RESPONSE REGULATOR receiver
Astex_1581	COG2205	protein histidine kinase activity
Astex_1587	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Astex_1589	COG2264	protein methyltransferase activity
Astex_1593	COG1396	sequence-specific DNA binding
Astex_1594	COG0483	inositol monophosphate 1-phosphatase activity
Astex_1601	COG3047	cAMP biosynthetic process
Astex_1602	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Astex_1602	COG0425	Belongs to the sulfur carrier protein TusA family
Astex_1606	COG0322	excinuclease ABC activity
Astex_1609	COG1028	Short-chain dehydrogenase reductase Sdr
Astex_1610	COG0142	geranyltranstransferase activity
Astex_1611	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Astex_1612	COG0542	response to heat
Astex_1616	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Astex_1617	COG0438	transferase activity, transferring glycosyl groups
Astex_1625	COG0840	transmembrane signaling receptor activity
Astex_1630	COG0772	Belongs to the SEDS family
Astex_1631	COG0768	penicillin binding
Astex_1636	COG0217	transcriptional regulatory protein
Astex_1637	COG1692	metallophosphoesterase
Astex_1639	COG0861	Integral membrane protein TerC family
Astex_1645	COG1278	Cold shock
Astex_1646	COG2813	Specifically methylates the guanine in position
Astex_1647	COG1187	pseudouridine synthase activity
Astex_1649	COG0745	RESPONSE REGULATOR receiver
Astex_1650	COG2205	protein histidine kinase activity
Astex_1652	COG0126	phosphoglycerate kinase activity
Astex_1654	COG0071	Belongs to the small heat shock protein (HSP20) family
Astex_1656	COG0626	cystathionine gamma-synthase activity
Astex_1657	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Astex_1659	COG4208	sulfate ABC transporter
Astex_1660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Astex_1662	COG4221	oxidoreductase activity
Astex_1664	COG4206	TonB-dependent receptor
Astex_1666	COG0006	proline dipeptidase activity
Astex_1668	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Astex_1669	COG0497	DNA recombination
Astex_1670	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Astex_1671	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Astex_1672	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Astex_1673	COG0849	cell division
Astex_1674	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Astex_1676	COG0037	tRNA processing
Astex_1679	COG2885	chlorophyll binding
Astex_1680	COG0823	Involved in the tonB-independent uptake of proteins
Astex_1684	COG2255	four-way junction helicase activity
Astex_1685	COG0632	four-way junction helicase activity
Astex_1686	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Astex_1692	COG0488	(ABC) transporter
Astex_1693	COG5001	Diguanylate cyclase
Astex_1693	COG3300	MHYT domain
Astex_1697	COG2971	BadF BadG BcrA BcrD
Astex_1698	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Astex_1699	COG2885	chlorophyll binding
Astex_1705	COG0163	prenyltransferase activity
Astex_1713	COG0352	thiamine-phosphate diphosphorylase activity
Astex_1715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Astex_1716	COG0483	inositol monophosphate 1-phosphatase activity
Astex_1717	COG1309	transcriptional regulator
Astex_1718	COG0300	oxidoreductase activity
Astex_1719	COG1132	(ABC) transporter
Astex_1720	COG0254	rRNA binding
Astex_1722	COG0387	Pfam Sodium calcium exchanger
Astex_1724	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Astex_1728	COG2171	N-acyltransferase activity
Astex_1730	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
Astex_1731	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Astex_1732	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Astex_1733	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Astex_1738	COG0489	protein tyrosine kinase activity
Astex_1739	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Astex_1742	COG0129	dihydroxy-acid dehydratase activity
Astex_1745	COG1012	belongs to the aldehyde dehydrogenase family
Astex_1750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Astex_1755	COG2755	lipolytic protein G-D-S-L family
Astex_1755	COG0657	acetylesterase activity
Astex_1758	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Astex_1759	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Astex_1763	COG0215	cysteine-tRNA ligase activity
Astex_1764	COG0302	gtp cyclohydrolase
Astex_1765	COG0848	biopolymer transport protein
Astex_1766	COG0564	pseudouridine synthase activity
Astex_1767	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Astex_1768	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Astex_1771	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Astex_1775	COG0351	phosphomethylpyrimidine kinase
Astex_1779	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Astex_1780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Astex_1781	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Astex_1785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Astex_1789	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Astex_1790	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Astex_1791	COG0174	glutamine synthetase
Astex_1792	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Astex_1793	COG1012	belongs to the aldehyde dehydrogenase family
Astex_1794	COG1012	belongs to the aldehyde dehydrogenase family
Astex_1801	COG1230	cation diffusion facilitator family transporter
Astex_1808	COG1522	sequence-specific DNA binding
Astex_1809	COG0686	Belongs to the AlaDH PNT family
Astex_1819	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Astex_1820	COG0072	phenylalanine-tRNA ligase activity
Astex_1820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Astex_1826	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Astex_1827	COG0594	ribonuclease P activity
Astex_1828	COG0706	membrane insertase activity
Astex_1829	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Astex_1834	COG0494	nUDIX hydrolase
Astex_1838	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Astex_1840	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Astex_1842	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Astex_1843	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Astex_1846	COG0275	rRNA processing
Astex_1847	COG2001	Belongs to the MraZ family
Astex_1851	COG3023	N-Acetylmuramoyl-L-alanine amidase
Astex_1853	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Astex_1858	COG0006	proline dipeptidase activity
Astex_1866	COG2226	methyltransferase
Astex_1868	COG3422	double-strand break repair
Astex_1870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Astex_1874	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Astex_1876	COG1959	2 iron, 2 sulfur cluster binding
Astex_1884	COG2308	Evidence 4 Homologs of previously reported genes of
Astex_1890	COG2272	Belongs to the type-B carboxylesterase lipase family
Astex_1891	COG1940	carbohydrate kinase activity
Astex_1896	COG0469	pyruvate kinase activity
Astex_1897	COG0295	cytidine deaminase activity
Astex_1899	COG0738	Major facilitator superfamily
Astex_1901	COG1414	Transcriptional regulator
Astex_1904	COG2721	sulfolactate sulfo-lyase activity
Astex_1905	COG1028	Short-chain dehydrogenase reductase Sdr
Astex_1908	COG0477	Major facilitator Superfamily
Astex_1908	COG2814	Major facilitator Superfamily
Astex_1909	COG0129	dihydroxy-acid dehydratase activity
Astex_1910	COG3386	PFAM SMP-30 Gluconolaconase
Astex_1920	COG0505	Belongs to the CarA family
Astex_1921	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Astex_1924	COG1505	serine-type exopeptidase activity
Astex_1926	COG1414	Transcriptional regulator
Astex_1927	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Astex_1929	COG3250	beta-galactosidase activity
Astex_1933	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Astex_1936	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Astex_1938	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Astex_1938	COG1918	ferrous iron import across plasma membrane
Astex_1941	COG2252	PERMEase
Astex_1947	COG1472	Belongs to the glycosyl hydrolase 3 family
Astex_1949	COG1609	Transcriptional regulator
Astex_1950	COG0800	Aldolase
Astex_1951	COG0837	glucose binding
Astex_1953	COG0363	glucosamine-6-phosphate deaminase activity
Astex_1954	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Astex_1955	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Astex_1958	COG0308	aminopeptidase N
Astex_1960	COG2202	Pas domain
Astex_1960	COG2205	protein histidine kinase activity
Astex_1961	COG0697	spore germination
Astex_1965	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Astex_1968	COG2205	protein histidine kinase activity
Astex_1971	COG1028	Short-chain dehydrogenase reductase Sdr
Astex_1972	COG5265	(ABC) transporter
Astex_1974	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Astex_1975	COG2819	hydrolase of the alpha beta superfamily
Astex_1979	COG1760	l-serine dehydratase
Astex_1986	COG1609	Transcriptional regulator
Astex_1990	COG5487	UPF0391 membrane protein
Astex_1992	COG1846	Transcriptional regulator
Astex_1993	COG2204	response regulator
Astex_1996	COG2205	protein histidine kinase activity
Astex_1996	COG0784	Response regulator, receiver
Astex_1998	COG5002	protein histidine kinase activity
Astex_2005	COG2186	Transcriptional regulator
Astex_2006	COG1301	dicarboxylic acid transport
Astex_2009	COG2197	response regulator
Astex_2011	COG2346	COG2346, Truncated hemoglobins
Astex_2013	COG3088	subunit of a heme lyase
Astex_2014	COG1138	Cytochrome C-type biogenesis protein
Astex_2015	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Astex_2018	COG2205	protein histidine kinase activity
Astex_2019	COG0745	RESPONSE REGULATOR receiver
Astex_2021	COG0484	heat shock protein binding
Astex_2022	COG2983	Belongs to the UPF0260 family
Astex_2027	COG0583	DNA-binding transcription factor activity
Astex_2028	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Astex_2029	COG1024	Enoyl-CoA hydratase
Astex_2030	COG0439	Biotin carboxylase
Astex_2031	COG1960	acyl-CoA dehydrogenase activity
Astex_2034	COG1024	Enoyl-CoA hydratase
Astex_2037	COG1522	sequence-specific DNA binding
Astex_2045	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Astex_2046	COG0028	Belongs to the TPP enzyme family
Astex_2047	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Astex_2048	COG1960	acyl-CoA dehydrogenase activity
Astex_2049	COG1012	belongs to the aldehyde dehydrogenase family
Astex_2050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Astex_2058	COG1609	Transcriptional regulator
Astex_2065	COG0583	DNA-binding transcription factor activity
Astex_2066	COG0667	Aldo Keto reductase
Astex_2069	COG0583	DNA-binding transcription factor activity
Astex_2072	COG1690	Belongs to the RtcB family
Astex_2084	COG1968	undecaprenyl-diphosphatase activity
Astex_2088	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Astex_2090	COG0166	Belongs to the GPI family
Astex_2094	COG0004	ammonium transporteR
Astex_2097	COG1012	belongs to the aldehyde dehydrogenase family
Astex_2101	COG1648	precorrin-2 dehydrogenase activity
Astex_2101	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Astex_2103	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Astex_2105	COG0175	sulfate reduction
Astex_2106	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Astex_2107	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Astex_2112	COG0513	Belongs to the DEAD box helicase family
Astex_2114	COG0784	Response regulator, receiver
Astex_2114	COG2205	protein histidine kinase activity
Astex_2118	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Astex_2121	COG0395	ABC-type sugar transport system, permease component
Astex_2122	COG1175	transmembrane transport
Astex_2131	COG1028	Short-chain dehydrogenase reductase Sdr
Astex_2133	COG1028	Short-chain dehydrogenase reductase Sdr
Astex_2134	COG1414	Transcriptional regulator
Astex_2135	COG4948	Mandelate Racemase Muconate Lactonizing
Astex_2137	COG1028	Short-chain dehydrogenase reductase Sdr
Astex_2141	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Astex_2146	COG1028	Short-chain dehydrogenase reductase Sdr
Astex_2148	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Astex_2151	COG1083	cytidylyl-transferase
Astex_2152	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Astex_2153	COG3550	peptidyl-serine autophosphorylation
Astex_2154	COG3620	sequence-specific DNA binding
Astex_2159	COG2755	lipolytic protein G-D-S-L family
Astex_2169	COG4952	isomerase
Astex_2173	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Astex_2179	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Astex_2181	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Astex_2192	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Astex_2193	COG3307	-O-antigen
Astex_2194	COG4372	Transposase
Astex_2195	COG3436	PFAM IS66 Orf2 family protein
Astex_2199	COG4372	Transposase
Astex_2212	COG0438	transferase activity, transferring glycosyl groups
Astex_2213	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Astex_2214	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Astex_2221	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Astex_2235	COG3505	Type IV secretory pathway VirD4
Astex_2248	COG3311	Transcriptional regulator
Astex_2249	COG1569	PIN domain
Astex_2250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Astex_2251	COG3932	Exopolysaccharide synthesis, ExoD
Astex_2252	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Astex_2258	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Astex_2259	COG1091	dTDP-4-dehydrorhamnose reductase activity
Astex_2260	COG1088	dTDP-glucose 4,6-dehydratase activity
Astex_2261	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Astex_2262	COG0339	signal peptide processing
Astex_2263	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Astex_2280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Astex_2281	COG0463	Glycosyl transferase, family 2
Astex_2281	COG1216	Glycosyl transferase, family 2
Astex_2283	COG0438	transferase activity, transferring glycosyl groups
Astex_2285	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Astex_2286	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Astex_2288	COG0175	sulfate reduction
Astex_2289	COG1218	3'(2'),5'-bisphosphate nucleotidase
Astex_2290	COG2942	2-epimerase
Astex_2296	COG1435	thymidine kinase activity
Astex_2300	COG1396	sequence-specific DNA binding
Astex_2303	COG0288	reversible hydration of carbon dioxide
Astex_2307	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Astex_2308	COG0545	Peptidyl-prolyl cis-trans isomerase
Astex_2309	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Astex_2310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Astex_2311	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Astex_2313	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Astex_2315	COG2835	tetraacyldisaccharide 4'-kinase activity
Astex_2317	COG0477	Major facilitator Superfamily
Astex_2319	COG0745	RESPONSE REGULATOR receiver
Astex_2320	COG0704	Plays a role in the regulation of phosphate uptake
Astex_2321	COG5002	protein histidine kinase activity
Astex_2322	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Astex_2324	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Astex_2328	COG2205	protein histidine kinase activity
Astex_2328	COG0784	Response regulator, receiver
Astex_2329	COG3300	MHYT domain
Astex_2329	COG5001	Diguanylate cyclase
Astex_2336	COG0492	ferredoxin-NADP+ reductase activity
Astex_2337	COG0583	DNA-binding transcription factor activity
Astex_2339	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Astex_2352	COG0358	DNA primase activity
Astex_2353	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Astex_2356	COG0285	dihydrofolate synthase activity
Astex_2358	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Astex_2359	COG0159	tryptophan synthase activity
Astex_2360	COG0133	tryptophan synthase activity
Astex_2361	COG0135	phosphoribosylanthranilate isomerase activity
Astex_2363	COG1970	mechanosensitive ion channel activity
Astex_2364	COG0776	regulation of translation
Astex_2365	COG0539	negative regulation of cytoplasmic translation
Astex_2366	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Astex_2369	COG3668	Plasmid stabilization system
Astex_2373	COG0667	Aldo Keto reductase
Astex_2374	COG0412	Dienelactone hydrolase
Astex_2375	COG5006	permease, DMT superfamily
Astex_2376	COG2814	Major facilitator Superfamily
Astex_2377	COG0514	ATP-dependent DNA helicase (RecQ)
Astex_2378	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Astex_2380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Astex_2381	COG0268	Binds directly to 16S ribosomal RNA
Astex_2385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Astex_2386	COG0587	DNA-directed DNA polymerase activity
Astex_2395	COG4771	TonB-dependent receptor
Astex_2397	COG1858	cytochrome C peroxidase
Astex_2401	COG1595	DNA-templated transcription, initiation
Astex_2403	COG2814	Major facilitator Superfamily
Astex_2404	COG3384	dioxygenase
Astex_2405	COG0583	DNA-binding transcription factor activity
Astex_2406	COG0583	DNA-binding transcription factor activity
Astex_2407	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Astex_2410	COG2159	amidohydrolase
Astex_2419	COG2197	response regulator
Astex_2427	COG2197	response regulator
Astex_2434	COG1476	TRANSCRIPTIONal
Astex_2441	COG1309	transcriptional regulator
Astex_2452	COG5489	Protein of unknown function (DUF736)
Astex_2460	COG4957	zinc ion binding
Astex_2461	COG0776	regulation of translation
Astex_2463	COG2084	Dehydrogenase
Astex_2466	COG3384	dioxygenase
Astex_2468	COG2814	Major facilitator Superfamily
Astex_2471	COG4638	Rieske (2fe-2S)
Astex_2472	COG4221	oxidoreductase activity
Astex_2478	COG0385	Bile acid
Astex_2481	COG4962	Type ii secretion system protein e
Astex_2482	COG3838	Conjugal transfer protein Trbc
Astex_2484	COG3451	type IV secretory pathway VirB4
Astex_2486	COG3846	protein secretion by the type IV secretion system
Astex_2489	COG2948	multi-organism process
Astex_2492	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Astex_2493	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Astex_2493	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Astex_2502	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Astex_2503	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Astex_2505	COG2119	membrane
Astex_2509	COG2755	lipolytic protein G-D-S-L family
Astex_2510	COG0538	isocitrate dehydrogenase activity
Astex_2511	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Astex_2515	COG3387	PFAM Glycoside hydrolase 15-related
Astex_2516	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Astex_2518	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Astex_2520	COG0583	DNA-binding transcription factor activity
Astex_2525	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Astex_2529	COG2072	flavoprotein involved in K transport
Astex_2530	COG2351	hydroxyisourate hydrolase activity
Astex_2531	COG2080	2 iron, 2 sulfur cluster binding
Astex_2532	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Astex_2534	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Astex_2535	COG0402	S-adenosylhomocysteine deaminase activity
Astex_2536	COG0316	Belongs to the HesB IscA family
Astex_2537	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Astex_2539	COG0346	lactoylglutathione lyase activity
Astex_2542	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Astex_2544	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Astex_2545	COG1607	acyl-coa hydrolase
Astex_2551	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Astex_2552	COG0154	amidase activity
Astex_2556	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Astex_2558	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Astex_2558	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Astex_2564	COG0481	GTPase activity
Astex_2566	COG3609	addiction module antidote protein, CC2985 family
Astex_2575	COG0673	inositol 2-dehydrogenase activity
Astex_2589	COG3345	alpha-galactosidase
Astex_2590	COG4948	Mandelate Racemase Muconate Lactonizing
Astex_2591	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Astex_2594	COG3250	beta-galactosidase activity
Astex_2596	COG2223	nitrite transmembrane transporter activity
Astex_2597	COG2201	protein-glutamate methylesterase activity
Astex_2598	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Astex_2598	COG1116	anion transmembrane transporter activity
Astex_2599	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Astex_2601	COG0243	molybdopterin cofactor binding
Astex_2602	COG3250	beta-galactosidase activity
Astex_2603	COG1741	Belongs to the pirin family
Astex_2612	COG3104	oligopeptide transport
Astex_2614	COG0312	modulator of DNA gyrase
Astex_2616	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Astex_2617	COG0109	protoheme IX farnesyltransferase activity
Astex_2619	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
Astex_2622	COG3346	SURF1 family
Astex_2623	COG0612	Peptidase, M16
Astex_2624	COG0584	glycerophosphoryl diester phosphodiesterase
Astex_2625	COG1678	Uncharacterized ACR, COG1678
Astex_2626	COG0678	peroxiredoxin activity
Astex_2626	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Astex_2627	COG1960	acyl-CoA dehydrogenase activity
Astex_2629	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Astex_2634	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Astex_2635	COG0602	queuosine metabolic process
Astex_2636	COG0248	Ppx GppA phosphatase
Astex_2639	COG0343	queuine tRNA-ribosyltransferase activity
Astex_2643	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Astex_2644	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Astex_2646	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Astex_2648	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Astex_2656	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Astex_2656	COG0519	Catalyzes the synthesis of GMP from XMP
Astex_2658	COG1484	DNA-dependent DNA replication
Astex_2659	COG4584	PFAM Integrase catalytic
Astex_2660	COG0582	viral genome integration into host DNA
Astex_2665	COG4962	Type ii secretion system protein e
Astex_2668	COG3451	type IV secretory pathway VirB4
Astex_2670	COG3846	protein secretion by the type IV secretion system
Astex_2673	COG2948	multi-organism process
Astex_2676	COG1278	Cold shock
Astex_2687	COG2205	protein histidine kinase activity
Astex_2688	COG0745	RESPONSE REGULATOR receiver
Astex_2691	COG1393	Belongs to the ArsC family
Astex_2693	COG1595	DNA-templated transcription, initiation
Astex_2695	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Astex_2698	COG1160	GTP binding
Astex_2699	COG0384	phenazine biosynthesis protein PhzF
Astex_2702	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Astex_2705	COG0305	Participates in initiation and elongation during chromosome replication
Astex_2711	COG2226	methyltransferase
Astex_2712	COG1301	dicarboxylic acid transport
Astex_2713	COG0544	peptidyl-prolyl cis-trans isomerase activity
Astex_2715	COG0740	serine-type endopeptidase activity
Astex_2716	COG0560	Phosphoserine phosphatase
Astex_2717	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Astex_2719	COG2971	BadF BadG BcrA BcrD
Astex_2720	COG3142	Participates in the control of copper homeostasis
Astex_2724	COG1472	Belongs to the glycosyl hydrolase 3 family
Astex_2727	COG3537	Alpha-1,2-mannosidase
Astex_2731	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Astex_2732	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Astex_2733	COG3152	Membrane
Astex_2734	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Astex_2736	COG0861	Integral membrane protein TerC family
Astex_2737	COG0412	Dienelactone hydrolase
Astex_2738	COG3152	Membrane
Astex_2739	COG2832	Protein of unknown function (DUF454)
Astex_2744	COG0250	Participates in transcription elongation, termination and antitermination
Astex_2745	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Astex_2746	COG0081	regulation of translation
Astex_2748	COG4977	sequence-specific DNA binding
Astex_2749	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Astex_2750	COG0222	ribosome binding
Astex_2753	COG0739	heme binding
Astex_2754	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Astex_2756	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Astex_2757	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Astex_2758	COG2945	thiolester hydrolase activity
Astex_2759	COG1959	2 iron, 2 sulfur cluster binding
Astex_2760	COG1104	cysteine desulfurase activity
Astex_2761	COG0719	Fe-S assembly protein
Astex_2763	COG0396	ATPase activity
Astex_2764	COG0719	Fe-S assembly protein
Astex_2765	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Astex_2766	COG2151	metal-sulfur cluster biosynthetic enzyme
Astex_2767	COG0316	Belongs to the HesB IscA family
Astex_2771	COG3706	GGDEF domain
Astex_2772	COG0513	Belongs to the DEAD box helicase family
Astex_2773	COG0187	DNA topoisomerase II activity
Astex_2776	COG0004	ammonium transporteR
Astex_2777	COG0174	glutamine synthetase
Astex_2778	COG0347	Belongs to the P(II) protein family
Astex_2780	COG0359	binds to the 23S rRNA
Astex_2782	COG0360	Binds together with S18 to 16S ribosomal RNA
Astex_2783	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Astex_2784	COG1073	alpha beta
Astex_2786	COG0412	Dienelactone hydrolase
Astex_2787	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Astex_2789	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Astex_2790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Astex_2791	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Astex_2792	COG1561	YicC-like family, N-terminal region
Astex_2793	COG0194	GDP metabolic process
Astex_2797	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Astex_2798	COG0776	regulation of translation
Astex_2803	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Astex_2804	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Astex_2805	COG0649	NAD binding
Astex_2808	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Astex_2809	COG2314	TM2 domain
Astex_2811	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Astex_2812	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Astex_2814	COG0713	ATP synthesis coupled electron transport
Astex_2817	COG1007	ATP synthesis coupled electron transport
Astex_2819	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Astex_2821	COG3243	poly(R)-hydroxyalkanoic acid synthase
Astex_2823	COG1494	fructose-1,6-bisphosphatase
Astex_2824	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Astex_2824	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Astex_2825	COG1278	Cold shock
Astex_2828	COG3034	peptidoglycan biosynthetic process
Astex_2832	COG1612	heme a metabolic process
Astex_2834	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Astex_2835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Astex_2836	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Astex_2839	COG0442	prolyl-tRNA aminoacylation
Astex_2841	COG1136	(ABC) transporter
Astex_2842	COG0587	DNA-directed DNA polymerase activity
Astex_2843	COG0052	Belongs to the universal ribosomal protein uS2 family
Astex_2844	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Astex_2845	COG0528	UMP kinase activity
Astex_2846	COG0233	cytoplasmic translational termination
Astex_2847	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Astex_2848	COG4589	Belongs to the CDS family
Astex_2849	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Astex_2850	COG0750	zinc metalloprotease
Astex_2851	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Astex_2853	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Astex_2854	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Astex_2855	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Astex_2856	COG3494	Protein of unknown function (DUF1009)
Astex_2857	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Astex_2858	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Astex_2859	COG0372	Belongs to the citrate synthase family
Astex_2862	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Astex_2863	COG0134	indole-3-glycerol-phosphate synthase activity
Astex_2864	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Astex_2867	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Astex_2868	COG1923	regulation of RNA biosynthetic process
Astex_2869	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Astex_2870	COG2204	response regulator
Astex_2871	COG5000	phosphorelay sensor kinase activity
Astex_2872	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Astex_2873	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Astex_2873	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Astex_2874	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Astex_2874	COG0321	lipoyl(octanoyl) transferase activity
Astex_2875	COG0084	hydrolase, TatD family'
Astex_2876	COG0470	DNA polymerase III
Astex_2877	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Astex_2884	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Astex_2885	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Astex_2886	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Astex_2889	COG0463	Glycosyl transferase, family 2
Astex_2890	COG0415	Belongs to the DNA photolyase family
Astex_2891	COG2897	thiosulfate sulfurtransferase activity
Astex_2892	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Astex_2894	COG0251	oxidation-reduction process
Astex_2895	COG0504	CTP synthase activity
Astex_2897	COG0149	triose-phosphate isomerase activity
Astex_2899	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Astex_2901	COG4651	solute:proton antiporter activity
Astex_2901	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Astex_2902	COG2211	Major facilitator Superfamily
Astex_2902	COG2190	(PTS) system
Astex_2903	COG3956	TIGRFAM MazG family protein
Astex_2904	COG0823	Involved in the tonB-independent uptake of proteins
Astex_2907	COG1131	(ABC) transporter
Astex_2908	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Astex_2909	COG1546	Belongs to the CinA family
Astex_2909	COG1058	Belongs to the CinA family
Astex_2911	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Astex_2913	COG0204	Acyl-transferase
Astex_2913	COG0318	PFAM AMP-dependent synthetase and ligase
Astex_2918	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Astex_2919	COG0508	dehydrogenase complex catalyzes the overall conversion of
Astex_2920	COG0508	dehydrogenase complex catalyzes the overall conversion of
Astex_2920	COG0022	dehydrogenase e1 component
Astex_2921	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Astex_2922	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Astex_2923	COG0148	phosphopyruvate hydratase activity
Astex_2924	COG0546	phosphoglycolate phosphatase activity
Astex_2925	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Astex_2928	COG0776	regulation of translation
Astex_2929	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Astex_2930	COG0416	fatty acid biosynthetic process
Astex_2934	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Astex_2936	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Astex_2937	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Astex_2938	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Astex_2939	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Astex_2939	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Astex_2942	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Astex_2943	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Astex_2947	COG0156	8-amino-7-oxononanoate synthase activity
Astex_2949	COG0113	porphobilinogen synthase activity
Astex_2950	COG2084	Dehydrogenase
Astex_2951	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Astex_2952	COG1360	Flagellar Motor Protein
Astex_2953	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Astex_2954	COG3932	Exopolysaccharide synthesis, ExoD
Astex_2955	COG3676	manually curated
Astex_2956	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Astex_2959	COG1381	Involved in DNA repair and RecF pathway recombination
Astex_2960	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Astex_2961	COG0571	ribonuclease III activity
Astex_2962	COG0681	Belongs to the peptidase S26 family
Astex_2963	COG0736	holo-[acyl-carrier-protein] synthase activity
Astex_2964	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Astex_2965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Astex_2967	COG1758	RNA polymerase activity
Astex_2969	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Astex_2971	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Astex_2972	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Astex_2973	COG0741	lytic transglycosylase activity
Astex_2974	COG1120	ATPase activity
Astex_2978	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Astex_2978	COG0116	Belongs to the methyltransferase superfamily
Astex_2979	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Astex_2983	COG1643	Atp-dependent helicase
Astex_2984	COG0531	amino acid
Astex_2985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Astex_2987	COG2081	HI0933 family
Astex_2989	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Astex_2990	COG0085	RNA polymerase activity
Astex_2994	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Astex_2995	COG1388	LysM domain
Astex_2995	COG0860	N-Acetylmuramoyl-L-alanine amidase
Astex_2996	COG1530	ribonuclease E activity
Astex_2997	COG0501	Belongs to the peptidase M48B family
Astex_3000	COG2022	thiamine diphosphate biosynthetic process
Astex_3001	COG2336	PFAM SpoVT AbrB
Astex_3005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Astex_3006	COG0511	ligase activity, forming carbon-carbon bonds
Astex_3007	COG0439	Biotin carboxylase
Astex_3009	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Astex_3012	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Astex_3015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Astex_3018	COG0248	Ppx GppA phosphatase
Astex_3020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Astex_3021	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Astex_3022	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Astex_3023	COG0105	UTP biosynthetic process
Astex_3024	COG0488	(ABC) transporter
Astex_3027	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Astex_3031	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Astex_3032	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Astex_3033	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Astex_3035	COG0235	Class ii aldolase
Astex_3037	COG0330	HflC and HflK could
Astex_3038	COG1051	belongs to the nudix hydrolase family
Astex_3039	COG0277	FAD linked oxidase domain protein
Astex_3040	COG0745	RESPONSE REGULATOR receiver
Astex_3041	COG3022	response to hydroperoxide
Astex_3042	COG0009	L-threonylcarbamoyladenylate synthase
Astex_3043	COG3038	cytochrome b561
Astex_3044	COG1960	acyl-CoA dehydrogenase activity
Astex_3050	COG3436	PFAM IS66 Orf2 family protein
Astex_3051	COG4372	Transposase
Astex_3053	COG1686	Belongs to the peptidase S11 family
Astex_3056	COG1192	Involved in chromosome partitioning
Astex_3057	COG0024	Methionine aminopeptidase
Astex_3058	COG2003	Belongs to the UPF0758 family
Astex_3059	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Astex_3060	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Astex_3062	COG3250	beta-galactosidase activity
Astex_3062	COG5297	Belongs to the glycosyl hydrolase family 6
Astex_3063	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Astex_3067	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Astex_3068	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Astex_3069	COG0047	phosphoribosylformylglycinamidine synthase activity
Astex_3070	COG0596	Alpha beta hydrolase
Astex_3071	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Astex_3075	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Astex_3077	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Astex_3078	COG1253	flavin adenine dinucleotide binding
Astex_3080	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Astex_3082	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Astex_3083	COG0840	transmembrane signaling receptor activity
Astex_3084	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Astex_3085	COG2032	superoxide dismutase activity
Astex_3086	COG0564	pseudouridine synthase activity
Astex_3092	COG0386	Belongs to the glutathione peroxidase family
Astex_3096	COG1741	Belongs to the pirin family
Astex_3099	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Astex_3100	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Astex_3101	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Astex_3102	COG0629	single-stranded DNA binding
Astex_3105	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Astex_3108	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Astex_3109	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Astex_3110	COG5442	Flagellar protein FlaF
Astex_3111	COG5443	negative regulation of bacterial-type flagellum assembly
Astex_3112	COG0457	Tetratricopeptide repeat
Astex_3112	COG0859	PFAM glycosyl transferase family 9
Astex_3114	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Astex_3116	COG3743	rRNA binding
Astex_3116	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Astex_3119	COG0574	Belongs to the PEP-utilizing enzyme family
Astex_3119	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Astex_3120	COG0751	glycine-tRNA ligase activity
Astex_3121	COG0752	glycyl-tRNA synthetase alpha subunit
Astex_3124	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Astex_3130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Astex_3136	COG0525	valine-tRNA ligase activity
Astex_3140	COG0840	transmembrane signaling receptor activity
Astex_3141	COG3706	GGDEF domain
Astex_3141	COG0745	RESPONSE REGULATOR receiver
Astex_3142	COG0784	Response regulator, receiver
Astex_3146	COG0546	phosphoglycolate phosphatase activity
Astex_3148	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Astex_3149	COG0537	adenosine 5'-monophosphoramidase activity
Astex_3150	COG0406	alpha-ribazole phosphatase activity
Astex_3151	COG3300	MHYT domain
Astex_3151	COG5001	Diguanylate cyclase
Astex_3154	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Astex_3166	COG1668	transmembrane transport
Astex_3167	COG4152	abc transporter atp-binding protein
Astex_3169	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Astex_3170	COG4585	Histidine kinase
Astex_3171	COG2197	response regulator
Astex_3174	COG4771	TonB-dependent receptor
Astex_3177	COG1297	OPT oligopeptide transporter protein
Astex_3178	COG4771	TonB-dependent receptor
Astex_3180	COG0154	amidase activity
Astex_3181	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Astex_3186	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Astex_3188	COG1064	alcohol dehydrogenase
Astex_3189	COG0540	Belongs to the ATCase OTCase family
Astex_3191	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Astex_3192	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Astex_3194	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Astex_3194	COG1754	DNA topoisomerase type I activity
Astex_3196	COG0431	NADPH-dependent FMN reductase
Astex_3198	COG3738	Protein conserved in bacteria
Astex_3207	COG3250	beta-galactosidase activity
Astex_3211	COG3291	Pkd domain containing protein
Astex_3211	COG4447	cellulose binding
Astex_3211	COG5520	Belongs to the glycosyl hydrolase 30 family
Astex_3212	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
Astex_3221	COG0784	Response regulator, receiver
Astex_3221	COG2205	protein histidine kinase activity
Astex_3225	COG3250	beta-galactosidase activity
Astex_3227	COG3152	Membrane
Astex_3234	COG4372	Transposase
Astex_3239	COG3590	peptidase
Astex_3242	COG0124	histidyl-tRNA synthetase
Astex_3244	COG2890	protein-(glutamine-N5) methyltransferase activity
Astex_3245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Astex_3246	COG0527	aspartate kinase activity
Astex_3247	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Astex_3248	COG4232	protein-disulfide reductase activity
Astex_3251	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Astex_3254	COG2226	methyltransferase
Astex_3255	COG0494	nUDIX hydrolase
Astex_3256	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Astex_3257	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Astex_3258	COG0653	protein targeting
Astex_3263	COG0204	Acyl-transferase
Astex_3266	COG2884	Cell division ATP-binding protein ftsE
Astex_3270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Astex_3271	COG3300	MHYT domain
Astex_3271	COG5001	Diguanylate cyclase
Astex_3273	COG5001	Diguanylate cyclase
Astex_3273	COG5002	protein histidine kinase activity
Astex_3278	COG0714	Associated with various cellular activities
Astex_3284	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Astex_3287	COG2068	MobA-Related Protein
Astex_3291	COG2205	protein histidine kinase activity
Astex_3291	COG0784	Response regulator, receiver
Astex_3293	COG2271	Major facilitator Superfamily
Astex_3296	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
Astex_3299	COG1448	Aminotransferase
Astex_3300	COG3254	rhamnose metabolic process
Astex_3301	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Astex_3303	COG1446	asparaginase
Astex_3304	COG4206	TonB-dependent receptor
Astex_3313	COG1501	Belongs to the glycosyl hydrolase 31 family
Astex_3315	COG1472	Belongs to the glycosyl hydrolase 3 family
Astex_3316	COG3534	alpha-L-arabinofuranosidase
Astex_3322	COG0784	Response regulator, receiver
Astex_3323	COG4251	negative regulation of phosphorylation
Astex_3327	COG0475	glutathione-regulated potassium exporter activity
Astex_3333	COG2011	ABC-type metal ion transport system permease component
Astex_3334	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Astex_3338	COG4948	Mandelate Racemase Muconate Lactonizing
Astex_3339	COG3661	Belongs to the glycosyl hydrolase 67 family
Astex_3343	COG1278	Cold shock
Astex_3346	COG2211	Major facilitator Superfamily
Astex_3347	COG1609	Transcriptional regulator
Astex_3350	COG4771	TonB-dependent receptor
Astex_3358	COG2866	Carboxypeptidase
Astex_3364	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Astex_3368	COG1609	Transcriptional regulator
Astex_3369	COG1028	Short-chain dehydrogenase reductase Sdr
Astex_3370	COG1304	FMN binding
Astex_3371	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Astex_3372	COG0581	inorganic phosphate transmembrane transporter activity
Astex_3373	COG0573	inorganic phosphate transmembrane transporter activity
Astex_3374	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Astex_3375	COG0840	transmembrane signaling receptor activity
Astex_3377	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Astex_3378	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Astex_3379	COG1538	Outer membrane efflux protein
Astex_3387	COG4957	zinc ion binding
Astex_3390	COG5001	Diguanylate cyclase
Astex_3392	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Astex_3397	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Astex_3398	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Astex_3399	COG0006	proline dipeptidase activity
Astex_3400	COG3250	beta-galactosidase activity
Astex_3403	COG2272	Belongs to the type-B carboxylesterase lipase family
Astex_3406	COG2204	response regulator
Astex_3407	COG4191	Histidine kinase
Astex_3408	COG1301	dicarboxylic acid transport
Astex_3410	COG3852	Histidine kinase
Astex_3411	COG2204	response regulator
Astex_3413	COG1136	(ABC) transporter
Astex_3414	COG0577	efflux transmembrane transporter activity
Astex_3415	COG2271	Major facilitator Superfamily
Astex_3418	COG1063	alcohol dehydrogenase
Astex_3420	COG4677	pectinesterase activity
Astex_3427	COG1028	Short-chain dehydrogenase reductase Sdr
Astex_3429	COG4771	TonB-dependent receptor
Astex_3430	COG0596	Alpha beta hydrolase
Astex_3430	COG2945	thiolester hydrolase activity
Astex_3431	COG1309	transcriptional regulator
Astex_3439	COG2010	Cytochrome c
Astex_3446	COG2321	neutral zinc metallopeptidase
Astex_3447	COG1309	transcriptional regulator
Astex_3448	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Astex_3451	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Astex_3452	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Astex_3453	COG4974	Belongs to the 'phage' integrase family
Astex_3454	COG0825	malonyl-CoA metabolic process
Astex_3458	COG0668	transmembrane transport
Astex_3460	COG0590	tRNA wobble adenosine to inosine editing
Astex_3461	COG1187	pseudouridine synthase activity
Astex_3462	COG0742	ribosomal rna small subunit methyltransferase
Astex_3464	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Astex_3466	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Astex_3467	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Astex_3469	COG1573	uracil-dna glycosylase
Astex_3471	COG1187	pseudouridine synthase activity
Astex_3472	COG0519	Catalyzes the synthesis of GMP from XMP
Astex_3475	COG4771	TonB-dependent receptor
Astex_3477	COG1595	DNA-templated transcription, initiation
Astex_3481	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Astex_3482	COG0484	heat shock protein binding
Astex_3483	COG0259	pyridoxamine-phosphate oxidase activity
Astex_3489	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Astex_3490	COG0557	exoribonuclease II activity
Astex_3492	COG0196	riboflavin kinase activity
Astex_3494	COG0745	RESPONSE REGULATOR receiver
Astex_3495	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Astex_3502	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Astex_3503	COG2201	protein-glutamate methylesterase activity
Astex_3507	COG1570	exodeoxyribonuclease VII activity
Astex_3511	COG0151	Belongs to the GarS family
Astex_3513	COG1663	tetraacyldisaccharide 4'-kinase activity
Astex_3514	COG1519	Transferase
Astex_3516	COG1132	(ABC) transporter
Astex_3520	COG0483	inositol monophosphate 1-phosphatase activity
Astex_3521	COG0312	modulator of DNA gyrase
Astex_3522	COG5001	Diguanylate cyclase
Astex_3522	COG3300	MHYT domain
Astex_3526	COG1785	Belongs to the alkaline phosphatase family
Astex_3527	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
Astex_3528	COG0415	Belongs to the DNA photolyase family
Astex_3531	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Astex_3544	COG2197	response regulator
Astex_3546	COG2204	response regulator
Astex_3551	COG2271	Major facilitator Superfamily
Astex_3561	COG1414	Transcriptional regulator
Astex_3562	COG0179	Fumarylacetoacetate (FAA) hydrolase
Astex_3568	COG0840	transmembrane signaling receptor activity
Astex_3569	COG1192	Involved in chromosome partitioning
Astex_3570	COG1475	DNA binding
Astex_3572	COG3940	Belongs to the glycosyl hydrolase 43 family
Astex_3573	COG3718	enzyme involved in inositol metabolism
Astex_3575	COG3962	Belongs to the TPP enzyme family
Astex_3576	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Astex_3578	COG0673	inositol 2-dehydrogenase activity
Astex_3579	COG3537	Alpha-1,2-mannosidase
Astex_3580	COG1172	Belongs to the binding-protein-dependent transport system permease family
Astex_3581	COG1129	ABC transporter
Astex_3582	COG1879	ABC-type sugar transport system periplasmic component
Astex_3584	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Astex_3585	COG1845	cytochrome c oxidase, subunit III
Astex_3586	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Astex_3587	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Astex_3600	COG3250	beta-galactosidase activity
Astex_3604	COG3250	beta-galactosidase activity
Astex_3613	COG3507	Belongs to the glycosyl hydrolase 43 family
Astex_3614	COG3250	beta-galactosidase activity
Astex_3615	COG2971	BadF BadG BcrA BcrD
Astex_3621	COG2186	Transcriptional regulator
Astex_3622	COG2186	Transcriptional regulator
Astex_3625	COG4941	Belongs to the sigma-70 factor family
Astex_3626	COG1082	Xylose isomerase domain protein TIM barrel
Astex_3630	COG0583	DNA-binding transcription factor activity
Astex_3632	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Astex_3639	COG0840	transmembrane signaling receptor activity
Astex_3646	COG0864	Transcriptional regulator
Astex_3648	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Astex_3660	COG1309	transcriptional regulator
Astex_3662	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Astex_3663	COG1538	Outer membrane efflux protein
Astex_3664	COG1028	Short-chain dehydrogenase reductase Sdr
Astex_3668	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Astex_3670	COG2271	Major facilitator Superfamily
Astex_3674	COG0583	DNA-binding transcription factor activity
Astex_3675	COG4771	TonB-dependent receptor
Astex_3676	COG1028	Short-chain dehydrogenase reductase Sdr
Astex_3677	COG4948	Mandelate Racemase Muconate Lactonizing
Astex_3679	COG2814	Major facilitator Superfamily
Astex_3680	COG0754	glutathionylspermidine amidase activity
Astex_3685	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Astex_3686	COG3177	Filamentation induced by cAMP protein fic
Astex_3687	COG3685	Protein conserved in bacteria
Astex_3697	COG3220	belongs to the UPF0276 family
Astex_3700	COG3220	belongs to the UPF0276 family
Astex_3702	COG1595	DNA-templated transcription, initiation
Astex_3705	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Astex_3720	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Astex_3744	COG3328	transposase activity
Astex_3754	COG0629	single-stranded DNA binding
Astex_3759	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Astex_3803	COG1476	TRANSCRIPTIONal
Astex_3805	COG4957	zinc ion binding
Astex_3806	COG2176	DNA-directed DNA polymerase activity
Astex_3807	COG0776	regulation of translation
Astex_3817	COG4644	lycopene metabolic process
Astex_3818	COG0640	Transcriptional regulator
Astex_3820	COG0798	PFAM Bile acid sodium symporter
Astex_3821	COG0431	NADPH-dependent FMN reductase
Astex_3822	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Astex_3826	COG0789	Transcriptional regulator
Astex_3827	COG2217	Heavy metal translocating P-type atpase
Astex_3831	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Astex_3842	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Astex_3847	COG1937	Protein conserved in bacteria
Astex_3848	COG2217	Heavy metal translocating P-type atpase
Astex_3849	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Astex_3852	COG2217	Heavy metal translocating P-type atpase