locus-tag	class	description
LH365_00025	COG0494	nUDIX hydrolase
LH365_00045	COG1959	2 iron, 2 sulfur cluster binding
LH365_00050	COG4221	oxidoreductase activity
LH365_00055	COG2095	MarC family integral membrane protein
LH365_00070	COG0501	Belongs to the peptidase M48B family
LH365_00080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LH365_00090	COG0138	bifunctional purine biosynthesis protein purh
LH365_00110	COG0180	Tryptophanyl-tRNA synthetase
LH365_00115	COG0728	peptidoglycan biosynthetic process
LH365_00120	COG0488	(ABC) transporter
LH365_00130	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LH365_00135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LH365_00140	COG0280	phosphate acetyltransferase
LH365_00140	COG0281	malic enzyme
LH365_00145	COG2814	Major facilitator Superfamily
LH365_00150	COG5002	protein histidine kinase activity
LH365_00150	COG2205	protein histidine kinase activity
LH365_00150	COG0784	Response regulator, receiver
LH365_00220	COG0189	ligase activity
LH365_00230	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LH365_00240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LH365_00245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LH365_00255	COG3655	Transcriptional regulator
LH365_00260	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LH365_00290	COG0412	Dienelactone hydrolase
LH365_00295	COG0443	Heat shock 70 kDa protein
LH365_00300	COG0484	heat shock protein binding
LH365_00305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LH365_00315	COG0756	dUTP diphosphatase activity
LH365_00320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LH365_00330	COG5001	Diguanylate cyclase
LH365_00350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LH365_00375	COG0802	atpase or kinase
LH365_00380	COG3178	'Phosphotransferase
LH365_00385	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LH365_00395	COG1074	ATP-dependent DNA helicase activity
LH365_00405	COG1597	lipid kinase activity
LH365_00410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LH365_00425	COG1674	ftsk spoiiie
LH365_00430	COG0251	oxidation-reduction process
LH365_00435	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LH365_00440	COG4953	penicillin-binding protein 1C
LH365_00455	COG2373	Large extracellular alpha-helical protein
LH365_00460	COG0745	RESPONSE REGULATOR receiver
LH365_00465	COG4771	TonB-dependent receptor
LH365_00470	COG0336	Belongs to the RNA methyltransferase TrmD family
LH365_00475	COG0335	large ribosomal subunit rRNA binding
LH365_00485	COG2133	pyrroloquinoline quinone binding
LH365_00490	COG4206	TonB-dependent receptor
LH365_00500	COG1185	polyribonucleotide nucleotidyltransferase activity
LH365_00505	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LH365_00510	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LH365_00535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LH365_00535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LH365_00550	COG0779	Required for maturation of 30S ribosomal subunits
LH365_00570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LH365_00575	COG1396	sequence-specific DNA binding
LH365_00580	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LH365_00585	COG1253	flavin adenine dinucleotide binding
LH365_00590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LH365_00595	COG1702	phosphate starvation-inducible protein PhoH
LH365_00600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH365_00630	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LH365_00645	COG0433	COG0433 Predicted ATPase
LH365_00665	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LH365_00670	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LH365_00675	COG0237	dephospho-CoA kinase activity
LH365_00685	COG0424	maF-like protein
LH365_00690	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LH365_00705	COG1981	membrane
LH365_00710	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LH365_00720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LH365_00775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LH365_00785	COG0745	RESPONSE REGULATOR receiver
LH365_00800	COG2205	protein histidine kinase activity
LH365_00810	COG0640	Transcriptional regulator
LH365_00825	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
LH365_00840	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
LH365_00855	COG0436	Aminotransferase
LH365_00870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LH365_00880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH365_00885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LH365_00890	COG1940	carbohydrate kinase activity
LH365_00890	COG1846	Transcriptional regulator
LH365_00910	COG0583	DNA-binding transcription factor activity
LH365_00920	COG2375	cellular response to nickel ion
LH365_00925	COG1695	Transcriptional regulator
LH365_00930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LH365_00935	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LH365_00940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH365_00950	COG0071	Belongs to the small heat shock protein (HSP20) family
LH365_00955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH365_00960	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LH365_00965	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LH365_00970	COG1137	ATPase activity
LH365_00985	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LH365_00990	COG0477	Major facilitator Superfamily
LH365_01015	COG0633	Ferredoxin
LH365_01025	COG1053	succinate dehydrogenase
LH365_01035	COG2009	succinate dehydrogenase
LH365_01090	COG2353	YceI-like domain
LH365_01115	COG2814	Major facilitator Superfamily
LH365_01120	COG0045	succinate-CoA ligase (ADP-forming) activity
LH365_01125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LH365_01140	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH365_01160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH365_01165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
LH365_01190	COG1253	flavin adenine dinucleotide binding
LH365_01200	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LH365_01205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LH365_01210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LH365_01215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LH365_01230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH365_01235	COG0552	protein localization to endoplasmic reticulum
LH365_01240	COG2917	probably involved in intracellular septation
LH365_01255	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_01260	COG3639	organic phosphonate transmembrane transporter activity
LH365_01265	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LH365_01270	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
LH365_01280	COG1959	2 iron, 2 sulfur cluster binding
LH365_01285	COG0492	ferredoxin-NADP+ reductase activity
LH365_01290	COG1899	peptidyl-lysine modification to peptidyl-hypusine
LH365_01300	COG1309	transcriptional regulator
LH365_01320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LH365_01325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH365_01335	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LH365_01340	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LH365_01345	COG5507	3-demethylubiquinone-9 3-methyltransferase
LH365_01350	COG5507	3-demethylubiquinone-9 3-methyltransferase
LH365_01370	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LH365_01385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LH365_01395	COG2124	cytochrome p450
LH365_01400	COG2204	response regulator
LH365_01405	COG4251	negative regulation of phosphorylation
LH365_01410	COG3401	FG-GAP repeat protein
LH365_01430	COG0670	Belongs to the BI1 family
LH365_01440	COG1785	Belongs to the alkaline phosphatase family
LH365_01445	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LH365_01455	COG0745	RESPONSE REGULATOR receiver
LH365_01460	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LH365_01515	COG4964	Belongs to the GSP D family
LH365_01565	COG0793	Belongs to the peptidase S41A family
LH365_01575	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LH365_01580	COG0799	negative regulation of ribosome biogenesis
LH365_01585	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LH365_01590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LH365_01605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LH365_01610	COG0523	cobalamin synthesis protein
LH365_01640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH365_01645	COG2885	chlorophyll binding
LH365_01655	COG1086	Polysaccharide biosynthesis protein
LH365_01660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LH365_01665	COG2089	acid synthase
LH365_01685	COG0243	molybdopterin cofactor binding
LH365_01690	COG1073	alpha beta
LH365_01695	COG0303	'Molybdopterin
LH365_01700	COG0521	Mo-molybdopterin cofactor biosynthetic process
LH365_01705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LH365_01710	COG2272	Belongs to the type-B carboxylesterase lipase family
LH365_01725	COG0246	Mannitol dehydrogenase
LH365_01730	COG2721	sulfolactate sulfo-lyase activity
LH365_01735	COG1609	Transcriptional regulator
LH365_01740	COG1904	glucuronate isomerase
LH365_01750	COG4221	oxidoreductase activity
LH365_01775	COG2852	Protein conserved in bacteria
LH365_01780	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
LH365_01785	COG4133	protoheme IX ABC transporter activity
LH365_01790	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LH365_01795	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LH365_01805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH365_01810	COG0077	Prephenate dehydratase
LH365_01810	COG1605	Chorismate mutase
LH365_01825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LH365_01850	COG2186	Transcriptional regulator
LH365_01860	COG3800	Transcriptional regulator
LH365_01860	COG1396	sequence-specific DNA binding
LH365_01870	COG2224	Isocitrate lyase
LH365_01890	COG2852	Protein conserved in bacteria
LH365_01895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH365_01895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH365_01930	COG0745	RESPONSE REGULATOR receiver
LH365_01935	COG2205	protein histidine kinase activity
LH365_01940	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
LH365_01945	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH365_01945	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH365_01950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LH365_01950	COG2169	Transcriptional regulator
LH365_01975	COG0121	glutamine amidotransferase
LH365_01980	COG1764	response to oxidative stress
LH365_02010	COG0730	response to heat
LH365_02020	COG1199	ATP-dependent helicase activity
LH365_02025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH365_02040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LH365_02050	COG1309	transcriptional regulator
LH365_02080	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH365_02090	COG2311	Membrane
LH365_02095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH365_02100	COG0165	Argininosuccinate lyase
LH365_02110	COG0019	diaminopimelate decarboxylase activity
LH365_02135	COG0717	Belongs to the dCTP deaminase family
LH365_02195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LH365_02200	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LH365_02205	COG0612	Peptidase, M16
LH365_02215	COG1462	curli production assembly transport component CsgG
LH365_02265	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LH365_02275	COG2884	Cell division ATP-binding protein ftsE
LH365_02290	COG0204	Acyl-transferase
LH365_02315	COG0653	protein targeting
LH365_02320	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH365_02325	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
LH365_02330	COG0494	nUDIX hydrolase
LH365_02340	COG2226	methyltransferase
LH365_02345	COG1040	competence protein
LH365_02350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LH365_02355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LH365_02370	COG4232	protein-disulfide reductase activity
LH365_02375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LH365_02385	COG0527	aspartate kinase activity
LH365_02395	COG2890	protein-(glutamine-N5) methyltransferase activity
LH365_02415	COG0124	histidyl-tRNA synthetase
LH365_02430	COG3590	peptidase
LH365_02465	COG3152	Membrane
LH365_02485	COG2852	Protein conserved in bacteria
LH365_02495	COG0459	protein refolding
LH365_02505	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LH365_02545	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LH365_02565	COG0714	Associated with various cellular activities
LH365_02590	COG0784	Response regulator, receiver
LH365_02590	COG4191	Histidine kinase
LH365_02610	COG1522	sequence-specific DNA binding
LH365_02615	COG0438	transferase activity, transferring glycosyl groups
LH365_02625	COG0482	sulfurtransferase activity
LH365_02650	COG1749	Flagellar hook protein flgE
LH365_02660	COG1766	The M ring may be actively involved in energy transduction
LH365_02665	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LH365_02675	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LH365_02680	COG2204	response regulator
LH365_02685	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LH365_02695	COG3693	PFAM glycoside hydrolase, family 10
LH365_02695	COG2382	esterase
LH365_02695	COG3507	Belongs to the glycosyl hydrolase 43 family
LH365_02760	COG2201	protein-glutamate methylesterase activity
LH365_02765	COG2201	protein-glutamate methylesterase activity
LH365_02775	COG0784	Response regulator, receiver
LH365_02775	COG2198	Histidine kinase
LH365_02775	COG0643	Histidine kinase
LH365_02795	COG4957	zinc ion binding
LH365_02805	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LH365_02820	COG2166	iron-sulfur cluster assembly
LH365_02825	COG2202	Pas domain
LH365_02825	COG2205	protein histidine kinase activity
LH365_02830	COG2205	protein histidine kinase activity
LH365_02850	COG2814	Major facilitator Superfamily
LH365_02855	COG1272	protein, Hemolysin III
LH365_02860	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LH365_02885	COG3273	potassium ion transport
LH365_02885	COG0471	metal ion transport
LH365_02890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH365_02895	COG0746	molybdenum cofactor guanylyltransferase activity
LH365_02900	COG2223	nitrite transmembrane transporter activity
LH365_02910	COG1116	anion transmembrane transporter activity
LH365_02910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH365_02915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH365_02925	COG0243	molybdopterin cofactor binding
LH365_02930	COG1116	anion transmembrane transporter activity
LH365_02935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH365_02940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH365_02950	COG3507	Belongs to the glycosyl hydrolase 43 family
LH365_02960	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LH365_02975	COG2271	Major facilitator Superfamily
LH365_02980	COG3507	Belongs to the glycosyl hydrolase 43 family
LH365_03035	COG2217	Heavy metal translocating P-type atpase
LH365_03040	COG2072	flavoprotein involved in K transport
LH365_03045	COG1558	bacterial-type flagellum-dependent cell motility
LH365_03050	COG1396	sequence-specific DNA binding
LH365_03075	COG2217	Heavy metal translocating P-type atpase
LH365_03140	COG0776	regulation of translation
LH365_03150	COG1396	sequence-specific DNA binding
LH365_03205	COG2132	Multicopper oxidase
LH365_03210	COG0789	Transcriptional regulator
LH365_03215	COG0640	Transcriptional regulator
LH365_03220	COG1230	cation diffusion facilitator family transporter
LH365_03225	COG0789	Transcriptional regulator
LH365_03295	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LH365_03300	COG3577	Aspartyl protease
LH365_03320	COG0840	transmembrane signaling receptor activity
LH365_03330	COG0556	nucleotide-excision repair
LH365_03355	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LH365_03365	COG0492	ferredoxin-NADP+ reductase activity
LH365_03395	COG0640	Transcriptional regulator
LH365_03405	COG2154	pterin-4-alpha-carbinolamine dehydratase
LH365_03410	COG3186	Phenylalanine-4-hydroxylase
LH365_03435	COG5002	protein histidine kinase activity
LH365_03445	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LH365_03450	COG2198	Histidine kinase
LH365_03450	COG2205	protein histidine kinase activity
LH365_03450	COG0784	Response regulator, receiver
LH365_03470	COG0655	NAD(P)H dehydrogenase (quinone) activity
LH365_03480	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LH365_03490	COG0450	alkyl hydroperoxide reductase
LH365_03540	COG0473	3-isopropylmalate dehydrogenase activity
LH365_03545	COG0066	3-isopropylmalate dehydratase activity
LH365_03550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LH365_03560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH365_03575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LH365_03585	COG0129	dihydroxy-acid dehydratase activity
LH365_03610	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LH365_03615	COG3162	membrane
LH365_03670	COG0181	hydroxymethylbilane synthase activity
LH365_03675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LH365_03680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LH365_03690	COG3609	addiction module antidote protein, CC2985 family
LH365_03705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LH365_03730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LH365_03745	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LH365_03755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LH365_03770	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LH365_03785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LH365_03805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH365_03820	COG4067	protein conserved in archaea
LH365_03820	COG0189	ligase activity
LH365_03855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH365_03865	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LH365_03885	COG4948	Mandelate Racemase Muconate Lactonizing
LH365_03900	COG3384	dioxygenase
LH365_03905	COG2353	YceI-like domain
LH365_03910	COG4771	TonB-dependent receptor
LH365_03945	COG0625	glutathione transferase activity
LH365_03955	COG0442	prolyl-tRNA aminoacylation
LH365_03970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LH365_03975	COG0385	Bile acid
LH365_03995	COG4948	Mandelate Racemase Muconate Lactonizing
LH365_04030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LH365_04035	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LH365_04040	COG0131	Imidazoleglycerol-phosphate dehydratase
LH365_04040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LH365_04050	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LH365_04060	COG0443	Heat shock 70 kDa protein
LH365_04080	COG1704	LemA family
LH365_04115	COG1522	sequence-specific DNA binding
LH365_04155	COG2885	chlorophyll binding
LH365_04160	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LH365_04170	COG2957	Belongs to the agmatine deiminase family
LH365_04185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LH365_04190	COG0840	transmembrane signaling receptor activity
LH365_04215	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LH365_04220	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LH365_04230	COG1322	Protein conserved in bacteria
LH365_04245	COG0242	peptide deformylase activity
LH365_04255	COG0101	tRNA pseudouridine synthase activity
LH365_04290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH365_04300	COG0598	Magnesium transport protein CorA
LH365_04315	COG4206	TonB-dependent receptor
LH365_04335	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LH365_04340	COG3300	MHYT domain
LH365_04340	COG5001	Diguanylate cyclase
LH365_04350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LH365_04360	COG0588	phosphoglycerate mutase activity
LH365_04365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH365_04365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH365_04380	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LH365_04385	COG4988	ABC transporter
LH365_04390	COG1271	oxidase subunit
LH365_04395	COG1294	oxidase, subunit
LH365_04405	COG1086	Polysaccharide biosynthesis protein
LH365_04415	COG0314	molybdopterin synthase activity
LH365_04420	COG0315	cyclic pyranopterin monophosphate synthase activity
LH365_04425	COG2264	protein methyltransferase activity
LH365_04435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
LH365_04450	COG0366	Alpha amylase catalytic
LH365_04460	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LH365_04475	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LH365_04490	COG0051	transcription antitermination factor activity, RNA binding
LH365_04495	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LH365_04505	COG0089	rRNA binding
LH365_04510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LH365_04515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LH365_04520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LH365_04525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
LH365_04535	COG0255	Belongs to the universal ribosomal protein uL29 family
LH365_04540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LH365_04545	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
LH365_04560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LH365_04580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LH365_04590	COG0200	Binds to the 23S rRNA
LH365_04595	COG0201	protein transport
LH365_04610	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LH365_04620	COG0203	ribosomal protein L17
LH365_04645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH365_04660	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
LH365_04715	COG1956	GAF domain-containing protein
LH365_04730	COG0823	Involved in the tonB-independent uptake of proteins
LH365_04730	COG1506	peptidase
LH365_04760	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LH365_04765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LH365_04770	COG4771	TonB-dependent receptor
LH365_04780	COG0318	PFAM AMP-dependent synthetase and ligase
LH365_04790	COG3237	CsbD-like
LH365_04820	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_04860	COG1994	Peptidase M50
LH365_04865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH365_04865	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LH365_04875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH365_04880	COG0174	glutamine synthetase
LH365_04900	COG3345	alpha-galactosidase
LH365_04950	COG1396	sequence-specific DNA binding
LH365_04995	COG1051	belongs to the nudix hydrolase family
LH365_05010	COG0702	epimerase
LH365_05015	COG1733	regulation of RNA biosynthetic process
LH365_05020	COG0800	Aldolase
LH365_05025	COG3734	2-keto-3-deoxy-galactonokinase
LH365_05035	COG0183	Belongs to the thiolase family
LH365_05040	COG1024	Enoyl-CoA hydratase
LH365_05040	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH365_05090	COG0753	catalase activity
LH365_05115	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LH365_05120	COG0640	Transcriptional regulator
LH365_05125	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LH365_05135	COG0387	Pfam Sodium calcium exchanger
LH365_05150	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LH365_05155	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LH365_05160	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LH365_05165	COG2205	protein histidine kinase activity
LH365_05170	COG0745	RESPONSE REGULATOR receiver
LH365_05185	COG1702	phosphate starvation-inducible protein PhoH
LH365_05210	COG0328	RNA-DNA hybrid ribonuclease activity
LH365_05215	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LH365_05235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LH365_05245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH365_05245	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH365_05250	COG4771	TonB-dependent receptor
LH365_05325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LH365_05350	COG2951	lytic endotransglycosylase activity
LH365_05360	COG0848	biopolymer transport protein
LH365_05390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH365_05390	COG2022	thiamine diphosphate biosynthetic process
LH365_05415	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LH365_05430	COG2321	neutral zinc metallopeptidase
LH365_05435	COG1309	transcriptional regulator
LH365_05450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LH365_05460	COG4974	Belongs to the 'phage' integrase family
LH365_05480	COG0668	transmembrane transport
LH365_05490	COG0590	tRNA wobble adenosine to inosine editing
LH365_05495	COG1187	pseudouridine synthase activity
LH365_05500	COG0742	ribosomal rna small subunit methyltransferase
LH365_05525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LH365_05530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LH365_05540	COG0196	riboflavin kinase activity
LH365_05550	COG0745	RESPONSE REGULATOR receiver
LH365_05555	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LH365_05575	COG4943	cyclic-guanylate-specific phosphodiesterase activity
LH365_05580	COG2201	protein-glutamate methylesterase activity
LH365_05600	COG0784	Response regulator, receiver
LH365_05600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH365_05600	COG2198	Histidine kinase
LH365_05600	COG2205	protein histidine kinase activity
LH365_05605	COG0745	RESPONSE REGULATOR receiver
LH365_05615	COG0151	Belongs to the GarS family
LH365_05625	COG1663	tetraacyldisaccharide 4'-kinase activity
LH365_05630	COG1519	Transferase
LH365_05640	COG1132	(ABC) transporter
LH365_05665	COG0483	inositol monophosphate 1-phosphatase activity
LH365_05670	COG0312	modulator of DNA gyrase
LH365_05675	COG5001	Diguanylate cyclase
LH365_05695	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LH365_05725	COG0431	NADPH-dependent FMN reductase
LH365_05735	COG1573	uracil-dna glycosylase
LH365_05745	COG1187	pseudouridine synthase activity
LH365_05750	COG0519	Catalyzes the synthesis of GMP from XMP
LH365_05765	COG4771	TonB-dependent receptor
LH365_05775	COG1595	DNA-templated transcription, initiation
LH365_05800	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LH365_05815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH365_05850	COG0557	exoribonuclease II activity
LH365_05855	COG2852	Protein conserved in bacteria
LH365_05860	COG1754	DNA topoisomerase type I activity
LH365_05860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LH365_05875	COG0758	DNA mediated transformation
LH365_05875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LH365_05885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LH365_05890	COG0540	Belongs to the ATCase OTCase family
LH365_05895	COG1064	alcohol dehydrogenase
LH365_05905	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LH365_05920	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LH365_05925	COG0154	amidase activity
LH365_05935	COG4771	TonB-dependent receptor
LH365_05940	COG1297	OPT oligopeptide transporter protein
LH365_05950	COG4771	TonB-dependent receptor
LH365_05965	COG2197	response regulator
LH365_05970	COG4585	Histidine kinase
LH365_05985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
LH365_05995	COG4152	abc transporter atp-binding protein
LH365_06000	COG1668	transmembrane transport
LH365_06070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH365_06080	COG3300	MHYT domain
LH365_06080	COG5001	Diguanylate cyclase
LH365_06085	COG0406	alpha-ribazole phosphatase activity
LH365_06090	COG0537	adenosine 5'-monophosphoramidase activity
LH365_06095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LH365_06130	COG0784	Response regulator, receiver
LH365_06175	COG0525	valine-tRNA ligase activity
LH365_06195	COG0463	Glycosyl transferase, family 2
LH365_06205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LH365_06255	COG0751	glycine-tRNA ligase activity
LH365_06260	COG0574	Belongs to the PEP-utilizing enzyme family
LH365_06260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LH365_06280	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LH365_06290	COG0457	Tetratricopeptide repeat
LH365_06290	COG0859	PFAM glycosyl transferase family 9
LH365_06300	COG5442	Flagellar protein FlaF
LH365_06310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LH365_06315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LH365_06330	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH365_06345	COG0629	single-stranded DNA binding
LH365_06360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LH365_06385	COG1741	Belongs to the pirin family
LH365_06395	COG1396	sequence-specific DNA binding
LH365_06400	COG0386	Belongs to the glutathione peroxidase family
LH365_06410	COG3250	beta-galactosidase activity
LH365_06435	COG0564	pseudouridine synthase activity
LH365_06440	COG2032	superoxide dismutase activity
LH365_06445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LH365_06450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH365_06470	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LH365_06485	COG1253	flavin adenine dinucleotide binding
LH365_06490	COG0840	transmembrane signaling receptor activity
LH365_06495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LH365_06505	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LH365_06525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LH365_06530	COG0047	phosphoribosylformylglycinamidine synthase activity
LH365_06535	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LH365_06540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LH365_06560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LH365_06565	COG5297	Belongs to the glycosyl hydrolase family 6
LH365_06565	COG2273	Hydrolase Family 16
LH365_06575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LH365_06580	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LH365_06585	COG2003	Belongs to the UPF0758 family
LH365_06615	COG0556	nucleotide-excision repair
LH365_06625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LH365_06645	COG0583	DNA-binding transcription factor activity
LH365_06665	COG3701	Conjugal transfer protein
LH365_06670	COG3846	protein secretion by the type IV secretion system
LH365_06685	COG3451	type IV secretory pathway VirB4
LH365_06700	COG4962	Type ii secretion system protein e
LH365_06730	COG0739	heme binding
LH365_06730	COG0741	lytic transglycosylase activity
LH365_06730	COG1196	nuclear chromosome segregation
LH365_06755	COG1192	Involved in chromosome partitioning
LH365_06790	COG5489	Protein of unknown function (DUF736)
LH365_06805	COG3012	SEC-C Motif Domain Protein
LH365_06840	COG1475	DNA binding
LH365_06870	COG2176	DNA-directed DNA polymerase activity
LH365_06885	COG2003	Belongs to the UPF0758 family
LH365_06890	COG0024	Methionine aminopeptidase
LH365_06895	COG0489	protein tyrosine kinase activity
LH365_06910	COG1686	Belongs to the peptidase S11 family
LH365_06935	COG1960	acyl-CoA dehydrogenase activity
LH365_06940	COG3038	cytochrome b561
LH365_06945	COG0009	L-threonylcarbamoyladenylate synthase
LH365_06950	COG3022	response to hydroperoxide
LH365_06955	COG0745	RESPONSE REGULATOR receiver
LH365_06965	COG0277	FAD linked oxidase domain protein
LH365_06970	COG1051	belongs to the nudix hydrolase family
LH365_06975	COG0330	HflC and HflK could
LH365_06980	COG1585	Membrane protein implicated in regulation of membrane protease activity
LH365_06985	COG0235	Class ii aldolase
LH365_06995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LH365_07000	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LH365_07005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH365_07025	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LH365_07040	COG0488	(ABC) transporter
LH365_07050	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LH365_07055	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LH365_07060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LH365_07070	COG0248	Ppx GppA phosphatase
LH365_07085	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LH365_07100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH365_07120	COG0439	Biotin carboxylase
LH365_07155	COG0501	Belongs to the peptidase M48B family
LH365_07160	COG1530	ribonuclease E activity
LH365_07170	COG0860	N-Acetylmuramoyl-L-alanine amidase
LH365_07170	COG1388	LysM domain
LH365_07175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LH365_07185	COG1295	ribonuclease BN
LH365_07195	COG0739	heme binding
LH365_07200	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LH365_07215	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LH365_07220	COG2945	thiolester hydrolase activity
LH365_07225	COG1959	2 iron, 2 sulfur cluster binding
LH365_07230	COG1104	cysteine desulfurase activity
LH365_07235	COG0719	Fe-S assembly protein
LH365_07240	COG0396	ATPase activity
LH365_07245	COG0719	Fe-S assembly protein
LH365_07250	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LH365_07260	COG0316	Belongs to the HesB IscA family
LH365_07290	COG0513	Belongs to the DEAD box helicase family
LH365_07295	COG0187	DNA topoisomerase II activity
LH365_07310	COG0004	ammonium transporteR
LH365_07315	COG0174	glutamine synthetase
LH365_07320	COG0347	Belongs to the P(II) protein family
LH365_07330	COG0359	binds to the 23S rRNA
LH365_07340	COG0360	Binds together with S18 to 16S ribosomal RNA
LH365_07345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LH365_07355	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LH365_07365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH365_07370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LH365_07375	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LH365_07380	COG1561	YicC-like family, N-terminal region
LH365_07385	COG0194	GDP metabolic process
LH365_07390	COG3474	cytochrome
LH365_07425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LH365_07455	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH365_07460	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH365_07465	COG0649	NAD binding
LH365_07480	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LH365_07485	COG2314	TM2 domain
LH365_07495	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LH365_07500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH365_07525	COG1007	ATP synthesis coupled electron transport
LH365_07535	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
LH365_07545	COG3243	poly(R)-hydroxyalkanoic acid synthase
LH365_07555	COG1494	fructose-1,6-bisphosphatase
LH365_07560	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LH365_07560	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
LH365_07575	COG1278	Cold shock
LH365_07625	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LH365_07630	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LH365_07655	COG1136	(ABC) transporter
LH365_07665	COG0052	Belongs to the universal ribosomal protein uS2 family
LH365_07675	COG0528	UMP kinase activity
LH365_07680	COG0233	cytoplasmic translational termination
LH365_07685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LH365_07690	COG4589	Belongs to the CDS family
LH365_07700	COG0750	zinc metalloprotease
LH365_07705	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH365_07715	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LH365_07720	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH365_07730	COG3494	Protein of unknown function (DUF1009)
LH365_07735	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LH365_07740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LH365_07745	COG0372	Belongs to the citrate synthase family
LH365_07750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH365_07755	COG0658	competence protein
LH365_07755	COG2333	competence protein COMEC
LH365_07760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LH365_07765	COG0134	indole-3-glycerol-phosphate synthase activity
LH365_07785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LH365_07800	COG2204	response regulator
LH365_07805	COG5000	phosphorelay sensor kinase activity
LH365_07820	COG0321	lipoyl(octanoyl) transferase activity
LH365_07820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LH365_07825	COG0084	hydrolase, TatD family'
LH365_07830	COG0470	DNA polymerase III
LH365_07835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LH365_07875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LH365_07880	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LH365_07885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LH365_07900	COG0463	Glycosyl transferase, family 2
LH365_07905	COG0415	Belongs to the DNA photolyase family
LH365_07910	COG2897	thiosulfate sulfurtransferase activity
LH365_07915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH365_07930	COG0251	oxidation-reduction process
LH365_07940	COG0504	CTP synthase activity
LH365_07945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LH365_07950	COG0149	triose-phosphate isomerase activity
LH365_07960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LH365_07970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH365_07970	COG4651	solute:proton antiporter activity
LH365_07980	COG3956	TIGRFAM MazG family protein
LH365_07985	COG0823	Involved in the tonB-independent uptake of proteins
LH365_07990	COG1733	regulation of RNA biosynthetic process
LH365_07995	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LH365_08000	COG1058	Belongs to the CinA family
LH365_08000	COG1546	Belongs to the CinA family
LH365_08040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH365_08045	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH365_08050	COG0022	dehydrogenase e1 component
LH365_08050	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH365_08055	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
LH365_08060	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LH365_08065	COG0148	phosphopyruvate hydratase activity
LH365_08070	COG0546	phosphoglycolate phosphatase activity
LH365_08100	COG0776	regulation of translation
LH365_08105	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LH365_08110	COG0416	fatty acid biosynthetic process
LH365_08130	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LH365_08140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LH365_08150	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LH365_08175	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LH365_08190	COG0156	8-amino-7-oxononanoate synthase activity
LH365_08200	COG0113	porphobilinogen synthase activity
LH365_08210	COG2084	Dehydrogenase
LH365_08215	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH365_08220	COG1360	Flagellar Motor Protein
LH365_08225	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LH365_08230	COG3932	Exopolysaccharide synthesis, ExoD
LH365_08235	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
LH365_08250	COG1381	Involved in DNA repair and RecF pathway recombination
LH365_08265	COG0681	Belongs to the peptidase S26 family
LH365_08270	COG0736	holo-[acyl-carrier-protein] synthase activity
LH365_08275	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LH365_08290	COG1758	RNA polymerase activity
LH365_08300	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LH365_08300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LH365_08320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH365_08330	COG0840	transmembrane signaling receptor activity
LH365_08335	COG1120	ATPase activity
LH365_08340	COG4139	cobalamin transport
LH365_08355	COG0116	Belongs to the methyltransferase superfamily
LH365_08355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LH365_08360	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH365_08380	COG1643	Atp-dependent helicase
LH365_08385	COG0531	amino acid
LH365_08390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH365_08400	COG2081	HI0933 family
LH365_08405	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LH365_08425	COG0222	ribosome binding
LH365_08430	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LH365_08435	COG3813	Protein conserved in bacteria
LH365_08440	COG4977	sequence-specific DNA binding
LH365_08455	COG0081	regulation of translation
LH365_08460	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LH365_08470	COG0250	Participates in transcription elongation, termination and antitermination
LH365_08500	COG3152	Membrane
LH365_08505	COG0412	Dienelactone hydrolase
LH365_08510	COG0861	Integral membrane protein TerC family
LH365_08515	COG4106	trans-aconitate 2-methyltransferase activity
LH365_08520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH365_08535	COG3152	Membrane
LH365_08555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LH365_08575	COG1301	dicarboxylic acid transport
LH365_08610	COG0305	Participates in initiation and elongation during chromosome replication
LH365_08625	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LH365_08630	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_08645	COG1160	GTP binding
LH365_08660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LH365_08670	COG1595	DNA-templated transcription, initiation
LH365_08685	COG1393	Belongs to the ArsC family
LH365_08695	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LH365_08730	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LH365_08755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LH365_08760	COG0436	Aminotransferase
LH365_08770	COG0343	queuine tRNA-ribosyltransferase activity
LH365_08790	COG0248	Ppx GppA phosphatase
LH365_08795	COG0602	queuosine metabolic process
LH365_08840	COG1960	acyl-CoA dehydrogenase activity
LH365_08850	COG1678	Uncharacterized ACR, COG1678
LH365_08855	COG0584	glycerophosphoryl diester phosphodiesterase
LH365_08865	COG0612	Peptidase, M16
LH365_08870	COG3346	SURF1 family
LH365_08880	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LH365_08890	COG0109	protoheme IX farnesyltransferase activity
LH365_08895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH365_08905	COG0312	modulator of DNA gyrase
LH365_08915	COG3104	oligopeptide transport
LH365_08955	COG1741	Belongs to the pirin family
LH365_08970	COG1054	Belongs to the UPF0176 family
LH365_08975	COG0616	signal peptide processing
LH365_09010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH365_09025	COG1706	bacterial-type flagellum-dependent cell motility
LH365_09045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LH365_09050	COG3338	carbonate dehydratase activity
LH365_09065	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
LH365_09085	COG1862	Preprotein translocase
LH365_09110	COG0784	Response regulator, receiver
LH365_09110	COG4191	Histidine kinase
LH365_09130	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LH365_09135	COG1530	ribonuclease E activity
LH365_09140	COG0424	maF-like protein
LH365_09145	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LH365_09155	COG5328	Belongs to the UPF0262 family
LH365_09200	COG0393	Putative heavy-metal-binding
LH365_09215	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LH365_09225	COG0460	homoserine dehydrogenase
LH365_09235	COG4221	oxidoreductase activity
LH365_09250	COG0626	cystathionine gamma-synthase activity
LH365_09255	COG1595	DNA-templated transcription, initiation
LH365_09260	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH365_09270	COG0667	Aldo Keto reductase
LH365_09275	COG1764	response to oxidative stress
LH365_09280	COG1846	Transcriptional regulator
LH365_09330	COG1496	oxidoreductase activity
LH365_09345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LH365_09350	COG0193	aminoacyl-tRNA hydrolase activity
LH365_09355	COG1819	glycosyl
LH365_09365	COG0012	GTP binding
LH365_09375	COG1418	mRNA catabolic process
LH365_09380	COG2857	Cytochrome c1
LH365_09380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LH365_09385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LH365_09385	COG2857	Cytochrome c1
LH365_09390	COG0723	plastoquinol--plastocyanin reductase activity
LH365_09395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LH365_09400	COG0408	coproporphyrinogen oxidase activity
LH365_09410	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH365_09410	COG0519	Catalyzes the synthesis of GMP from XMP
LH365_09425	COG3153	acetyltransferase
LH365_09430	COG1024	Enoyl-CoA hydratase
LH365_09440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LH365_09450	COG0354	folic acid binding
LH365_09480	COG1194	a g-specific adenine glycosylase
LH365_09490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LH365_09500	COG1802	Transcriptional regulator
LH365_09515	COG0356	it plays a direct role in the translocation of protons across the membrane
LH365_09525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LH365_09530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LH365_09540	COG2239	Acts as a magnesium transporter
LH365_09565	COG0321	lipoyl(octanoyl) transferase activity
LH365_09570	COG3152	Membrane
LH365_09585	COG0564	pseudouridine synthase activity
LH365_09600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LH365_09620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH365_09625	COG1278	Cold shock
LH365_09635	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LH365_09650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LH365_09655	COG0142	geranyltranstransferase activity
LH365_09670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LH365_09685	COG1595	DNA-templated transcription, initiation
LH365_09700	COG1501	Belongs to the glycosyl hydrolase 31 family
LH365_09710	COG2186	Transcriptional regulator
LH365_09720	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LH365_09725	COG1684	flagellar biosynthetic protein fliR
LH365_09730	COG1987	bacterial-type flagellum assembly
LH365_09735	COG1677	Flagellar hook-basal body complex protein FliE
LH365_09740	COG1558	bacterial-type flagellum-dependent cell motility
LH365_09750	COG3190	flagellar
LH365_09755	COG1338	Plays a role in the flagellum-specific transport system
LH365_09765	COG3609	addiction module antidote protein, CC2985 family
LH365_09815	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LH365_09825	COG0405	Gamma-glutamyltransferase
LH365_09840	COG0772	Belongs to the SEDS family
LH365_09845	COG0768	penicillin binding
LH365_09870	COG0436	Aminotransferase
LH365_09875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LH365_09890	COG0783	Belongs to the Dps family
LH365_09900	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LH365_09915	COG1566	PFAM secretion protein HlyD family protein
LH365_09920	COG1136	(ABC) transporter
LH365_09930	COG4786	Flagellar basal body rod
LH365_09935	COG4786	Flagellar basal body rod
LH365_09940	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
LH365_09945	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LH365_09955	COG0167	dihydroorotate dehydrogenase activity
LH365_09970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH365_09990	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
LH365_10005	COG0463	Glycosyl transferase, family 2
LH365_10035	COG0114	fumarate hydratase activity
LH365_10050	COG1132	(ABC) transporter
LH365_10060	COG3842	ATPase activity
LH365_10080	COG0174	glutamine synthetase
LH365_10085	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LH365_10090	COG1012	belongs to the aldehyde dehydrogenase family
LH365_10095	COG1012	belongs to the aldehyde dehydrogenase family
LH365_10105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
LH365_10125	COG1230	cation diffusion facilitator family transporter
LH365_10155	COG0217	transcriptional regulatory protein
LH365_10160	COG1692	metallophosphoesterase
LH365_10170	COG0861	Integral membrane protein TerC family
LH365_10205	COG1278	Cold shock
LH365_10210	COG2813	Specifically methylates the guanine in position
LH365_10215	COG1187	pseudouridine synthase activity
LH365_10230	COG0642	Histidine kinase
LH365_10255	COG0071	Belongs to the small heat shock protein (HSP20) family
LH365_10260	COG2378	regulation of single-species biofilm formation
LH365_10265	COG0626	cystathionine gamma-synthase activity
LH365_10270	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LH365_10280	COG4208	sulfate ABC transporter
LH365_10285	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LH365_10300	COG4206	TonB-dependent receptor
LH365_10305	COG0006	proline dipeptidase activity
LH365_10315	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LH365_10320	COG0497	DNA recombination
LH365_10325	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH365_10330	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LH365_10340	COG0849	cell division
LH365_10360	COG0037	tRNA processing
LH365_10375	COG2885	chlorophyll binding
LH365_10380	COG0823	Involved in the tonB-independent uptake of proteins
LH365_10405	COG2255	four-way junction helicase activity
LH365_10410	COG0632	four-way junction helicase activity
LH365_10415	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LH365_10465	COG0640	Transcriptional regulator
LH365_10475	COG3300	MHYT domain
LH365_10475	COG5001	Diguanylate cyclase
LH365_10485	COG2706	6-phosphogluconolactonase activity
LH365_10490	COG2188	Transcriptional regulator
LH365_10505	COG0738	Major facilitator superfamily
LH365_10510	COG2971	BadF BadG BcrA BcrD
LH365_10515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LH365_10520	COG2885	chlorophyll binding
LH365_10565	COG0024	Methionine aminopeptidase
LH365_10590	COG1063	alcohol dehydrogenase
LH365_10605	COG0352	thiamine-phosphate diphosphorylase activity
LH365_10610	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_10620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LH365_10625	COG0483	inositol monophosphate 1-phosphatase activity
LH365_10630	COG1309	transcriptional regulator
LH365_10640	COG1132	(ABC) transporter
LH365_10650	COG0387	Pfam Sodium calcium exchanger
LH365_10680	COG2171	N-acyltransferase activity
LH365_10690	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
LH365_10695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LH365_10700	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LH365_10705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LH365_10720	COG3077	Addiction module antitoxin, RelB DinJ family
LH365_10725	COG0489	protein tyrosine kinase activity
LH365_10730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LH365_10740	COG0129	dihydroxy-acid dehydratase activity
LH365_10765	COG1012	belongs to the aldehyde dehydrogenase family
LH365_10805	COG0210	DNA helicase
LH365_10825	COG0657	acetylesterase activity
LH365_10825	COG2755	lipolytic protein G-D-S-L family
LH365_10840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LH365_10860	COG0215	cysteine-tRNA ligase activity
LH365_10865	COG0302	gtp cyclohydrolase
LH365_10870	COG0848	biopolymer transport protein
LH365_10875	COG0564	pseudouridine synthase activity
LH365_10885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH365_10905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LH365_10910	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LH365_10920	COG0351	phosphomethylpyrimidine kinase
LH365_10920	COG0352	thiamine-phosphate diphosphorylase activity
LH365_10945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LH365_10950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LH365_10990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LH365_11010	COG0072	phenylalanine-tRNA ligase activity
LH365_11010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH365_11030	COG0640	Transcriptional regulator
LH365_11055	COG0706	membrane insertase activity
LH365_11080	COG0494	nUDIX hydrolase
LH365_11100	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LH365_11125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LH365_11130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LH365_11235	COG3023	N-Acetylmuramoyl-L-alanine amidase
LH365_11265	COG0006	proline dipeptidase activity
LH365_11295	COG1181	Belongs to the D-alanine--D-alanine ligase family
LH365_11315	COG1410	methionine synthase
LH365_11315	COG0646	methionine synthase
LH365_11325	COG2226	methyltransferase
LH365_11335	COG3422	double-strand break repair
LH365_11345	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LH365_11380	COG1609	Transcriptional regulator
LH365_11385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LH365_11405	COG0587	DNA-directed DNA polymerase activity
LH365_11410	COG1309	transcriptional regulator
LH365_11415	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_11420	COG0251	oxidation-reduction process
LH365_11425	COG1309	transcriptional regulator
LH365_11465	COG2222	sugar isomerase
LH365_11490	COG3345	alpha-galactosidase
LH365_11495	COG1349	DNA-binding transcription factor activity
LH365_11545	COG2814	Major facilitator Superfamily
LH365_11550	COG2186	Transcriptional regulator
LH365_11555	COG4948	Mandelate Racemase Muconate Lactonizing
LH365_11560	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_11570	COG0745	RESPONSE REGULATOR receiver
LH365_11575	COG4251	negative regulation of phosphorylation
LH365_11580	COG5002	protein histidine kinase activity
LH365_11585	COG0745	RESPONSE REGULATOR receiver
LH365_11595	COG2201	protein-glutamate methylesterase activity
LH365_11600	COG1959	2 iron, 2 sulfur cluster binding
LH365_11640	COG2308	Evidence 4 Homologs of previously reported genes of
LH365_11670	COG1940	carbohydrate kinase activity
LH365_11695	COG0469	pyruvate kinase activity
LH365_11700	COG0295	cytidine deaminase activity
LH365_11710	COG0738	Major facilitator superfamily
LH365_11720	COG1414	Transcriptional regulator
LH365_11735	COG2721	sulfolactate sulfo-lyase activity
LH365_11740	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_11755	COG2814	Major facilitator Superfamily
LH365_11755	COG0477	Major facilitator Superfamily
LH365_11760	COG0129	dihydroxy-acid dehydratase activity
LH365_11765	COG3386	PFAM SMP-30 Gluconolaconase
LH365_11810	COG1278	Cold shock
LH365_11815	COG0505	Belongs to the CarA family
LH365_11835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LH365_11855	COG1505	serine-type exopeptidase activity
LH365_11865	COG1414	Transcriptional regulator
LH365_11870	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LH365_11885	COG3250	beta-galactosidase activity
LH365_11905	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_11930	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LH365_11940	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LH365_11940	COG1918	ferrous iron import across plasma membrane
LH365_11960	COG2252	PERMEase
LH365_11995	COG1472	Belongs to the glycosyl hydrolase 3 family
LH365_12000	COG1609	Transcriptional regulator
LH365_12005	COG0800	Aldolase
LH365_12010	COG0837	glucose binding
LH365_12015	COG0129	dihydroxy-acid dehydratase activity
LH365_12020	COG0363	glucosamine-6-phosphate deaminase activity
LH365_12025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LH365_12030	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LH365_12045	COG0308	aminopeptidase N
LH365_12055	COG2202	Pas domain
LH365_12055	COG2205	protein histidine kinase activity
LH365_12065	COG0300	oxidoreductase activity
LH365_12070	COG0697	spore germination
LH365_12085	COG1595	DNA-templated transcription, initiation
LH365_12090	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LH365_12100	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_12110	COG2205	protein histidine kinase activity
LH365_12125	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_12130	COG5265	(ABC) transporter
LH365_12140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
LH365_12145	COG2819	hydrolase of the alpha beta superfamily
LH365_12150	COG1082	Xylose isomerase domain protein TIM barrel
LH365_12155	COG1609	Transcriptional regulator
LH365_12165	COG1760	l-serine dehydratase
LH365_12200	COG1609	Transcriptional regulator
LH365_12220	COG5487	UPF0391 membrane protein
LH365_12225	COG2267	carboxylic ester hydrolase activity
LH365_12230	COG1846	Transcriptional regulator
LH365_12240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LH365_12245	COG2205	protein histidine kinase activity
LH365_12255	COG2205	protein histidine kinase activity
LH365_12255	COG0784	Response regulator, receiver
LH365_12265	COG5002	protein histidine kinase activity
LH365_12295	COG2186	Transcriptional regulator
LH365_12300	COG1301	dicarboxylic acid transport
LH365_12315	COG2346	COG2346, Truncated hemoglobins
LH365_12325	COG3088	subunit of a heme lyase
LH365_12330	COG1138	Cytochrome C-type biogenesis protein
LH365_12365	COG0484	heat shock protein binding
LH365_12455	COG2983	Belongs to the UPF0260 family
LH365_12460	COG0488	(ABC) transporter
LH365_12475	COG2982	Protein involved in outer membrane biogenesis
LH365_12480	COG0339	signal peptide processing
LH365_12490	COG0583	DNA-binding transcription factor activity
LH365_12495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LH365_12500	COG1024	Enoyl-CoA hydratase
LH365_12505	COG0439	Biotin carboxylase
LH365_12510	COG1960	acyl-CoA dehydrogenase activity
LH365_12525	COG1024	Enoyl-CoA hydratase
LH365_12540	COG1522	sequence-specific DNA binding
LH365_12555	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH365_12560	COG1960	acyl-CoA dehydrogenase activity
LH365_12565	COG1012	belongs to the aldehyde dehydrogenase family
LH365_12570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH365_12620	COG1609	Transcriptional regulator
LH365_12640	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LH365_12650	COG3550	peptidyl-serine autophosphorylation
LH365_12685	COG3727	T/G mismatch-specific endonuclease activity
LH365_12720	COG0582	viral genome integration into host DNA
LH365_12755	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LH365_12765	COG0166	Belongs to the GPI family
LH365_12770	COG1012	belongs to the aldehyde dehydrogenase family
LH365_12785	COG0004	ammonium transporteR
LH365_12820	COG3609	addiction module antidote protein, CC2985 family
LH365_12830	COG1083	cytidylyl-transferase
LH365_12835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LH365_12835	COG1648	precorrin-2 dehydrogenase activity
LH365_12845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH365_12855	COG0175	sulfate reduction
LH365_12885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH365_12895	COG0513	Belongs to the DEAD box helicase family
LH365_12900	COG0308	aminopeptidase N
LH365_12905	COG0745	RESPONSE REGULATOR receiver
LH365_12920	COG3971	2-oxopent-4-enoate hydratase activity
LH365_12925	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
LH365_12940	COG0395	ABC-type sugar transport system, permease component
LH365_12945	COG1175	transmembrane transport
LH365_12950	COG3842	ATPase activity
LH365_12965	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_12975	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_12980	COG1414	Transcriptional regulator
LH365_12985	COG4948	Mandelate Racemase Muconate Lactonizing
LH365_12995	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_13035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH365_13055	COG2755	lipolytic protein G-D-S-L family
LH365_13080	COG4952	isomerase
LH365_13100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LH365_13120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH365_13135	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LH365_13140	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LH365_13145	COG3932	Exopolysaccharide synthesis, ExoD
LH365_13165	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
LH365_13170	COG1091	dTDP-4-dehydrorhamnose reductase activity
LH365_13175	COG1088	dTDP-glucose 4,6-dehydratase activity
LH365_13180	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
LH365_13185	COG0339	signal peptide processing
LH365_13190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LH365_13205	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH365_13255	COG1215	transferase activity, transferring glycosyl groups
LH365_13260	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LH365_13295	COG0438	transferase activity, transferring glycosyl groups
LH365_13295	COG1216	Glycosyl transferase, family 2
LH365_13300	COG0463	Glycosyl transferase, family 2
LH365_13305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH365_13315	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LH365_13320	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LH365_13330	COG0175	sulfate reduction
LH365_13335	COG1218	3'(2'),5'-bisphosphate nucleotidase
LH365_13340	COG2942	2-epimerase
LH365_13360	COG1435	thymidine kinase activity
LH365_13365	COG2816	NAD+ diphosphatase activity
LH365_13375	COG0288	reversible hydration of carbon dioxide
LH365_13385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LH365_13400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH365_13415	COG2835	tetraacyldisaccharide 4'-kinase activity
LH365_13425	COG0477	Major facilitator Superfamily
LH365_13430	COG0745	RESPONSE REGULATOR receiver
LH365_13440	COG5002	protein histidine kinase activity
LH365_13445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LH365_13480	COG0492	ferredoxin-NADP+ reductase activity
LH365_13485	COG0583	DNA-binding transcription factor activity
LH365_13495	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LH365_13505	COG0358	DNA primase activity
LH365_13510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LH365_13515	COG0285	dihydrofolate synthase activity
LH365_13530	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LH365_13535	COG0539	negative regulation of cytoplasmic translation
LH365_13555	COG0135	phosphoribosylanthranilate isomerase activity
LH365_13560	COG0133	tryptophan synthase activity
LH365_13565	COG0159	tryptophan synthase activity
LH365_13590	COG0667	Aldo Keto reductase
LH365_13605	COG2814	Major facilitator Superfamily
LH365_13610	COG0514	ATP-dependent DNA helicase (RecQ)
LH365_13615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LH365_13625	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LH365_13630	COG0268	Binds directly to 16S ribosomal RNA
LH365_13645	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LH365_13650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH365_13680	COG0823	Involved in the tonB-independent uptake of proteins
LH365_13680	COG1506	peptidase
LH365_13700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH365_13705	COG1136	(ABC) transporter
LH365_13705	COG0577	efflux transmembrane transporter activity
LH365_13720	COG2132	Multicopper oxidase
LH365_13735	COG1609	Transcriptional regulator
LH365_13740	COG0477	Major facilitator Superfamily
LH365_13765	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LH365_13790	COG0754	glutathionylspermidine amidase activity
LH365_13825	COG0805	protein transport
LH365_13830	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LH365_13835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LH365_13840	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
LH365_13845	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
LH365_13850	COG1472	Belongs to the glycosyl hydrolase 3 family
LH365_13860	COG1671	Belongs to the UPF0178 family
LH365_13875	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
LH365_13890	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
LH365_13905	COG2271	Major facilitator Superfamily
LH365_13925	COG2186	Transcriptional regulator
LH365_13935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LH365_13945	COG0583	DNA-binding transcription factor activity
LH365_13970	COG3685	Protein conserved in bacteria
LH365_13975	COG1914	H( )-stimulated, divalent metal cation uptake system
LH365_14005	COG1793	dna ligase
LH365_14010	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LH365_14010	COG1793	dna ligase
LH365_14015	COG1201	RNA secondary structure unwinding
LH365_14030	COG1472	Belongs to the glycosyl hydrolase 3 family
LH365_14035	COG3534	alpha-L-arabinofuranosidase
LH365_14065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH365_14090	COG1742	UPF0060 membrane protein
LH365_14095	COG0534	Mate efflux family protein
LH365_14105	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LH365_14120	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LH365_14130	COG0546	phosphoglycolate phosphatase activity
LH365_14225	COG0475	glutathione-regulated potassium exporter activity
LH365_14225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH365_14235	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LH365_14265	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LH365_14285	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LH365_14290	COG0745	RESPONSE REGULATOR receiver
LH365_14320	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LH365_14330	COG2264	protein methyltransferase activity
LH365_14345	COG0612	Peptidase, M16
LH365_14350	COG1396	sequence-specific DNA binding
LH365_14355	COG0483	inositol monophosphate 1-phosphatase activity
LH365_14385	COG1472	Belongs to the glycosyl hydrolase 3 family
LH365_14390	COG3047	cAMP biosynthetic process
LH365_14400	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LH365_14415	COG0322	excinuclease ABC activity
LH365_14435	COG0142	geranyltranstransferase activity
LH365_14440	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LH365_14450	COG0542	response to heat
LH365_14470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LH365_14475	COG0438	transferase activity, transferring glycosyl groups
LH365_14525	COG1285	pathogenesis
LH365_14560	COG1940	carbohydrate kinase activity
LH365_14560	COG1846	Transcriptional regulator
LH365_14580	COG4771	TonB-dependent receptor
LH365_14590	COG1595	DNA-templated transcription, initiation
LH365_14595	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH365_14615	COG0583	DNA-binding transcription factor activity
LH365_14645	COG1446	asparaginase
LH365_14655	COG4206	TonB-dependent receptor
LH365_14695	COG0784	Response regulator, receiver
LH365_14700	COG4251	negative regulation of phosphorylation
LH365_14720	COG0475	glutathione-regulated potassium exporter activity
LH365_14745	COG2011	ABC-type metal ion transport system permease component
LH365_14750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LH365_14770	COG4771	TonB-dependent receptor
LH365_14775	COG3250	beta-galactosidase activity
LH365_14780	COG4948	Mandelate Racemase Muconate Lactonizing
LH365_14785	COG3661	Belongs to the glycosyl hydrolase 67 family
LH365_14800	COG1278	Cold shock
LH365_14815	COG2211	Major facilitator Superfamily
LH365_14820	COG1609	Transcriptional regulator
LH365_14840	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
LH365_14880	COG2866	Carboxypeptidase
LH365_14915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LH365_14935	COG1609	Transcriptional regulator
LH365_14940	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_14945	COG1304	FMN binding
LH365_14955	COG0697	spore germination
LH365_14960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH365_14970	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LH365_14975	COG0581	inorganic phosphate transmembrane transporter activity
LH365_14980	COG0573	inorganic phosphate transmembrane transporter activity
LH365_14985	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LH365_14995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH365_15000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH365_15045	COG4957	zinc ion binding
LH365_15070	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
LH365_15095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH365_15100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH365_15135	COG3250	beta-galactosidase activity
LH365_15185	COG4206	TonB-dependent receptor
LH365_15195	COG0531	amino acid
LH365_15200	COG2204	response regulator
LH365_15205	COG4191	Histidine kinase
LH365_15210	COG1301	dicarboxylic acid transport
LH365_15220	COG3852	Histidine kinase
LH365_15225	COG2204	response regulator
LH365_15235	COG1136	(ABC) transporter
LH365_15240	COG0577	efflux transmembrane transporter activity
LH365_15245	COG2271	Major facilitator Superfamily
LH365_15250	COG0596	Alpha beta hydrolase
LH365_15250	COG2945	thiolester hydrolase activity
LH365_15260	COG3507	Belongs to the glycosyl hydrolase 43 family
LH365_15280	COG1063	alcohol dehydrogenase
LH365_15330	COG0583	DNA-binding transcription factor activity
LH365_15340	COG1028	Short-chain dehydrogenase reductase Sdr
LH365_15390	COG0438	transferase activity, transferring glycosyl groups
LH365_15395	COG0366	Alpha amylase catalytic
LH365_15400	COG0596	Alpha beta hydrolase
LH365_15410	COG5002	protein histidine kinase activity
LH365_15440	COG0438	transferase activity, transferring glycosyl groups
LH365_15530	COG0667	Aldo Keto reductase
LH365_15535	COG2207	Transcriptional regulator
LH365_15605	COG0464	growth
LH365_15625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH365_15695	COG4962	Type ii secretion system protein e
LH365_15710	COG3451	type IV secretory pathway VirB4
LH365_15720	COG3846	protein secretion by the type IV secretion system
LH365_15730	COG3504	Conjugal transfer protein
LH365_15735	COG2948	multi-organism process
LH365_15755	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH365_15760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LH365_15760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LH365_15765	COG2771	luxR family
LH365_15780	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LH365_15810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LH365_15820	COG2119	membrane
LH365_15840	COG2755	lipolytic protein G-D-S-L family
LH365_15845	COG2755	lipolytic protein G-D-S-L family
LH365_15850	COG0538	isocitrate dehydrogenase activity
LH365_15860	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LH365_15915	COG0823	Involved in the tonB-independent uptake of proteins
LH365_15915	COG1506	peptidase
LH365_15915	COG4946	Tricorn protease homolog
LH365_15920	COG4206	TonB-dependent receptor
LH365_15935	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LH365_15940	COG3254	rhamnose metabolic process
LH365_15945	COG1448	Aminotransferase
LH365_15960	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LH365_15975	COG2271	Major facilitator Superfamily
LH365_16020	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
LH365_16050	COG0714	Associated with various cellular activities
LH365_16075	COG5001	Diguanylate cyclase
LH365_16075	COG5002	protein histidine kinase activity
LH365_16085	COG5001	Diguanylate cyclase
LH365_16085	COG3300	MHYT domain
LH365_16090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH365_16110	COG3387	PFAM Glycoside hydrolase 15-related
LH365_16115	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
LH365_16120	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LH365_16155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LH365_16175	COG2072	flavoprotein involved in K transport
LH365_16180	COG2351	hydroxyisourate hydrolase activity
LH365_16185	COG2080	2 iron, 2 sulfur cluster binding
LH365_16190	COG1529	Aldehyde oxidase and xanthine dehydrogenase
LH365_16200	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LH365_16205	COG0402	S-adenosylhomocysteine deaminase activity
LH365_16215	COG0316	Belongs to the HesB IscA family
LH365_16225	COG0346	lactoylglutathione lyase activity
LH365_16235	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LH365_16240	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LH365_16250	COG0828	Belongs to the bacterial ribosomal protein bS21 family
LH365_16255	COG1607	acyl-coa hydrolase
LH365_16285	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH365_16295	COG0154	amidase activity
LH365_16310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LH365_16320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH365_16320	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LH365_16350	COG2197	response regulator
LH365_16390	COG0673	inositol 2-dehydrogenase activity
LH365_16455	COG2205	protein histidine kinase activity
LH365_16475	COG4591	ABC-type transport system involved in lipoprotein release permease component
LH365_16475	COG1136	(ABC) transporter
LH365_16545	COG2264	protein methyltransferase activity
LH365_16550	COG4771	TonB-dependent receptor
LH365_16555	COG0583	DNA-binding transcription factor activity
LH365_16565	COG2271	Major facilitator Superfamily
LH365_16570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH365_16575	COG1609	Transcriptional regulator
LH365_16605	COG2211	Major facilitator Superfamily
LH365_16615	COG1595	DNA-templated transcription, initiation
LH365_16630	COG5002	protein histidine kinase activity
LH365_16630	COG2205	protein histidine kinase activity
LH365_16630	COG0784	Response regulator, receiver
LH365_16645	COG3250	beta-galactosidase activity
LH365_16655	COG3250	beta-galactosidase activity
LH365_16675	COG3867	Arabinogalactan endo-beta-1,4-galactanase
LH365_16720	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
LH365_16730	COG0297	glycogen (starch) synthase activity
LH365_16735	COG0438	transferase activity, transferring glycosyl groups
LH365_16740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH365_16750	COG1045	serine acetyltransferase
LH365_16760	COG0438	transferase activity, transferring glycosyl groups
LH365_16775	COG1045	serine acetyltransferase
LH365_16785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH365_16800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LH365_16805	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH365_16815	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH365_16860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LH365_16870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LH365_16875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH365_16880	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LH365_16885	COG1522	sequence-specific DNA binding
LH365_16895	COG2259	Doxx family
LH365_16915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH365_16965	COG1702	phosphate starvation-inducible protein PhoH
LH365_16985	COG1309	transcriptional regulator
LH365_17000	COG0673	inositol 2-dehydrogenase activity
LH365_17025	COG0069	glutamate synthase activity
LH365_17045	COG1217	gtp-binding protein TYPA
LH365_17075	COG4251	negative regulation of phosphorylation
LH365_17080	COG4251	negative regulation of phosphorylation
LH365_17100	COG4774	siderophore transport
LH365_17105	COG3128	pkhd-type hydroxylase
LH365_17125	COG1477	protein flavinylation
LH365_17130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LH365_17140	COG3046	protein related to deoxyribodipyrimidine photolyase
LH365_17155	COG4771	TonB-dependent receptor
LH365_17160	COG0457	Tetratricopeptide repeat
LH365_17180	COG2755	lipolytic protein G-D-S-L family
LH365_17180	COG0657	acetylesterase activity
LH365_17185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH365_17215	COG3459	Glycosyltransferase 36 associated
LH365_17220	COG3682	Transcriptional regulator
LH365_17240	COG5002	protein histidine kinase activity
LH365_17240	COG2205	protein histidine kinase activity
LH365_17240	COG0784	Response regulator, receiver
LH365_17300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LH365_17310	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
LH365_17310	COG0392	lysyltransferase activity
LH365_17330	COG1546	Belongs to the CinA family
LH365_17330	COG1058	Belongs to the CinA family
LH365_17345	COG4941	Belongs to the sigma-70 factor family
LH365_17365	COG0583	DNA-binding transcription factor activity
LH365_17450	COG1309	transcriptional regulator
LH365_17480	COG0784	Response regulator, receiver
LH365_17480	COG2198	Histidine kinase
LH365_17480	COG2205	protein histidine kinase activity
LH365_17490	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LH365_17495	COG1335	isochorismatase
LH365_17505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH365_17510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH365_17515	COG0277	FAD linked oxidase domain protein
LH365_17525	COG2824	Alkylphosphonate utilization operon protein PhnA
LH365_17545	COG0753	catalase activity
LH365_17555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LH365_17580	COG0596	Alpha beta hydrolase
LH365_17595	COG1309	transcriptional regulator
LH365_17605	COG1131	(ABC) transporter
LH365_17610	COG0842	Transport permease protein
LH365_17620	COG4771	TonB-dependent receptor
LH365_17630	COG1506	peptidase
LH365_17630	COG4946	Tricorn protease homolog
LH365_17630	COG0823	Involved in the tonB-independent uptake of proteins
LH365_17705	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
LH365_17760	COG1846	Transcriptional regulator
LH365_17780	COG0667	Aldo Keto reductase
LH365_17785	COG1473	amidohydrolase
LH365_17800	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
LH365_17820	COG3451	type IV secretory pathway VirB4
LH365_17835	COG0741	lytic transglycosylase activity
LH365_17885	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH365_17885	COG0475	glutathione-regulated potassium exporter activity
LH365_17890	COG2971	BadF BadG BcrA BcrD
LH365_17910	COG2186	Transcriptional regulator
LH365_17915	COG2188	Transcriptional regulator
LH365_17990	COG2271	Major facilitator Superfamily
LH365_18005	COG1609	Transcriptional regulator
LH365_18015	COG5001	Diguanylate cyclase
LH365_18020	COG3300	MHYT domain
LH365_18020	COG5001	Diguanylate cyclase
LH365_18045	COG1262	PFAM Formylglycine-generating sulfatase enzyme
LH365_18050	COG5634	Uncharacterized conserved protein (DUF2278)
LH365_18095	COG3275	phosphorelay sensor kinase activity
LH365_18100	COG3279	Response regulator of the LytR AlgR family
LH365_18120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LH365_18125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH365_18130	COG1845	cytochrome c oxidase, subunit III
LH365_18135	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LH365_18140	COG3177	Filamentation induced by cAMP protein fic
LH365_18145	COG3940	Belongs to the glycosyl hydrolase 43 family
LH365_18165	COG1192	Involved in chromosome partitioning
LH365_18215	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH365_18220	COG1414	Transcriptional regulator
LH365_18235	COG2271	Major facilitator Superfamily
LH365_18240	COG3250	beta-galactosidase activity
LH365_18265	COG1472	Belongs to the glycosyl hydrolase 3 family
LH365_18270	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LH365_18330	COG3012	SEC-C Motif Domain Protein
LH365_18370	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
LH365_18405	COG0446	pyridine nucleotide-disulphide oxidoreductase
LH365_18410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH365_18425	COG0640	Transcriptional regulator
LH365_18515	COG1309	transcriptional regulator
LH365_18525	COG3422	double-strand break repair