locus-tag	class	description
J4859_00035	COG1725	Transcriptional regulator
J4859_00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
J4859_00055	COG0187	DNA topoisomerase II activity
J4859_00065	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
J4859_00070	COG0592	DNA-directed DNA polymerase activity
J4859_00085	COG0230	Belongs to the bacterial ribosomal protein bL34 family
J4859_00090	COG0594	ribonuclease P activity
J4859_00095	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
J4859_00105	COG1847	R3H domain protein
J4859_00110	COG0357	Ribosomal RNA small subunit methyltransferase G
J4859_00115	COG1192	Involved in chromosome partitioning
J4859_00120	COG1475	DNA binding
J4859_00130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
J4859_00135	COG1181	Belongs to the D-alanine--D-alanine ligase family
J4859_00140	COG1199	ATP-dependent helicase activity
J4859_00185	COG3547	Transposase (IS116 IS110 IS902 family)
J4859_00235	COG0137	argininosuccinate synthase activity
J4859_00240	COG0165	Argininosuccinate lyase
J4859_00245	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
J4859_00260	COG0745	RESPONSE REGULATOR receiver
J4859_00265	COG5002	protein histidine kinase activity
J4859_00270	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
J4859_00295	COG2815	serine threonine protein kinase
J4859_00295	COG0515	serine threonine protein kinase
J4859_00305	COG0631	protein serine/threonine phosphatase activity
J4859_00320	COG2815	serine threonine protein kinase
J4859_00320	COG0515	serine threonine protein kinase
J4859_00335	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
J4859_00355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J4859_00370	COG2188	Transcriptional regulator
J4859_00380	COG1217	gtp-binding protein TYPA
J4859_00405	COG0360	Binds together with S18 to 16S ribosomal RNA
J4859_00410	COG0629	single-stranded DNA binding
J4859_00415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
J4859_00425	COG0359	binds to the 23S rRNA
J4859_00430	COG0305	Participates in initiation and elongation during chromosome replication
J4859_00440	COG0151	Belongs to the GarS family
J4859_00445	COG0494	nUDIX hydrolase
J4859_00455	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
J4859_00465	COG4509	Sortase family
J4859_00470	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
J4859_00475	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
J4859_00480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
J4859_00490	COG3442	glutamine amidotransferase
J4859_00515	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J4859_00520	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
J4859_00525	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
J4859_00560	COG1194	a g-specific adenine glycosylase
J4859_00565	COG1592	Rubrerythrin
J4859_00570	COG2873	o-acetylhomoserine
J4859_00575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
J4859_00580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J4859_00585	COG0058	SHG alpha-glucan phosphorylase activity
J4859_00590	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J4859_00595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
J4859_00600	COG0297	glycogen (starch) synthase activity
J4859_00610	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
J4859_00630	COG2188	Transcriptional regulator
J4859_00635	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
J4859_00650	COG1484	DNA-dependent DNA replication
J4859_00670	COG2723	6-phospho-beta-galactosidase activity
J4859_00675	COG2190	(PTS) system
J4859_00675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4859_00675	COG1263	PTS System
J4859_00710	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
J4859_00715	COG0363	glucosamine-6-phosphate deaminase activity
J4859_00725	COG4466	Protein conserved in bacteria
J4859_00730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
J4859_00745	COG1737	Transcriptional regulator
J4859_00765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4859_00775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4859_00775	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4859_00785	COG2723	6-phospho-beta-galactosidase activity
J4859_00790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4859_00795	COG2723	6-phospho-beta-galactosidase activity
J4859_00845	COG1070	Carbohydrate kinase
J4859_00850	COG4806	L-rhamnose isomerase
J4859_00855	COG0235	Class ii aldolase
J4859_00890	COG4115	mRNA cleavage
J4859_00915	COG3547	Transposase (IS116 IS110 IS902 family)
J4859_00930	COG1609	Transcriptional regulator
J4859_00935	COG1904	glucuronate isomerase
J4859_00940	COG0246	Mannitol dehydrogenase
J4859_00945	COG2721	sulfolactate sulfo-lyase activity
J4859_00975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J4859_00975	COG0731	radical SAM domain protein
J4859_00985	COG1846	Transcriptional regulator
J4859_00990	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
J4859_01005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
J4859_01015	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
J4859_01020	COG0511	ligase activity, forming carbon-carbon bonds
J4859_01025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
J4859_01030	COG0439	Biotin carboxylase
J4859_01040	COG1307	EDD domain protein, DegV family
J4859_01045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J4859_01050	COG1882	Formate acetyltransferase
J4859_01070	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J4859_01135	COG0765	amino acid transport
J4859_01140	COG1126	abc transporter atp-binding protein
J4859_01155	COG1011	Hydrolase
J4859_01160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J4859_01165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
J4859_01170	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
J4859_01180	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
J4859_01185	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J4859_01195	COG0215	cysteine-tRNA ligase activity
J4859_01230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
J4859_01240	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J4859_01245	COG0250	Participates in transcription elongation, termination and antitermination
J4859_01250	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
J4859_01255	COG0081	regulation of translation
J4859_01260	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
J4859_01265	COG0222	ribosome binding
J4859_01285	COG2801	Transposase and inactivated derivatives
J4859_01325	COG0085	RNA polymerase activity
J4859_01330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
J4859_01360	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J4859_01395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4859_01395	COG3711	transcriptional antiterminator
J4859_01405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4859_01410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4859_01415	COG0383	alpha-mannosidase activity
J4859_01425	COG3547	Transposase (IS116 IS110 IS902 family)
J4859_01505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4859_01630	COG3547	Transposase (IS116 IS110 IS902 family)
J4859_01655	COG0656	L-ascorbic acid biosynthetic process
J4859_01710	COG2222	sugar isomerase
J4859_01715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4859_01720	COG4166	transmembrane transport
J4859_01725	COG0601	transmembrane transport
J4859_01730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J4859_01735	COG0444	Belongs to the ABC transporter superfamily
J4859_01740	COG4608	Belongs to the ABC transporter superfamily
J4859_01745	COG2188	Transcriptional regulator
J4859_01780	COG1088	dTDP-glucose 4,6-dehydratase activity
J4859_01790	COG0438	transferase activity, transferring glycosyl groups
J4859_01820	COG3475	LICD family
J4859_01825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
J4859_01840	COG3328	transposase activity
J4859_01855	COG2188	Transcriptional regulator
J4859_01865	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J4859_01875	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4859_01880	COG3715	PTS system
J4859_01885	COG3716	PTS system mannose fructose sorbose family IID component
J4859_01900	COG0191	fructose-bisphosphate aldolase activity
J4859_01955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
J4859_01960	COG0438	transferase activity, transferring glycosyl groups
J4859_01965	COG1216	Glycosyl transferase, family 2
J4859_02000	COG1215	transferase activity, transferring glycosyl groups
J4859_02035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4859_02040	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4859_02065	COG2188	Transcriptional regulator
J4859_02070	COG3328	transposase activity
J4859_02090	COG1733	regulation of RNA biosynthetic process
J4859_02100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
J4859_02105	COG0049	tRNA binding
J4859_02110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J4859_02115	COG0051	transcription antitermination factor activity, RNA binding
J4859_02120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
J4859_02125	COG0088	Forms part of the polypeptide exit tunnel
J4859_02130	COG0089	rRNA binding
J4859_02135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
J4859_02145	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
J4859_02150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
J4859_02155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
J4859_02160	COG0255	Belongs to the universal ribosomal protein uL29 family
J4859_02165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
J4859_02170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
J4859_02175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
J4859_02180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J4859_02195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
J4859_02200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
J4859_02205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
J4859_02210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
J4859_02215	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
J4859_02220	COG1841	ribosomal large subunit assembly
J4859_02225	COG0200	Binds to the 23S rRNA
J4859_02230	COG0201	protein transport
J4859_02235	COG0563	adenylate kinase activity
J4859_02270	COG0191	fructose-bisphosphate aldolase activity
J4859_02290	COG3716	PTS system mannose fructose sorbose family IID component
J4859_02315	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
J4859_02325	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
J4859_02330	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
J4859_02335	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
J4859_02345	COG0203	ribosomal protein L17
J4859_02350	COG1122	ATPase activity
J4859_02355	COG0101	tRNA pseudouridine synthase activity
J4859_02385	COG0463	Glycosyl transferase, family 2
J4859_02390	COG1216	Glycosyl transferase, family 2
J4859_02400	COG0493	'glutamate synthase
J4859_02400	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
J4859_02405	COG0543	2 iron, 2 sulfur cluster binding
J4859_02410	COG0193	aminoacyl-tRNA hydrolase activity
J4859_02425	COG1737	Transcriptional regulator
J4859_02430	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
J4859_02445	COG2826	transposase and inactivated derivatives, IS30 family
J4859_02470	COG1063	alcohol dehydrogenase
J4859_02475	COG3775	system Galactitol-specific IIC component
J4859_02480	COG3414	Phosphotransferase system galactitol-specific IIB component
J4859_02485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4859_02490	COG3711	transcriptional antiterminator
J4859_02490	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4859_02500	COG1105	Belongs to the carbohydrate kinase PfkB family
J4859_02510	COG1349	DNA-binding transcription factor activity
J4859_02585	COG2217	Heavy metal translocating P-type atpase
J4859_02590	COG2217	Heavy metal translocating P-type atpase
J4859_02665	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
J4859_02670	COG2188	Transcriptional regulator
J4859_02675	COG2723	6-phospho-beta-galactosidase activity
J4859_02685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4859_02690	COG1447	Phosphotransferase system cellobiose-specific component IIA
J4859_02705	COG0142	geranyltranstransferase activity
J4859_02710	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
J4859_02715	COG2910	NAD(P)H-binding
J4859_02740	COG0446	pyridine nucleotide-disulphide oxidoreductase
J4859_02755	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J4859_02785	COG4221	oxidoreductase activity
J4859_02795	COG0523	cobalamin synthesis protein
J4859_02800	COG0561	phosphatase activity
J4859_02805	COG1773	rubredoxin
J4859_02805	COG1592	Rubrerythrin
J4859_02810	COG0735	belongs to the Fur family
J4859_02815	COG1263	PTS System
J4859_02815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4859_02815	COG2190	(PTS) system
J4859_02820	COG0138	bifunctional purine biosynthesis protein purh
J4859_02835	COG1349	DNA-binding transcription factor activity
J4859_02840	COG1105	Belongs to the carbohydrate kinase PfkB family
J4859_02845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4859_02845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4859_02845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
J4859_02850	COG1254	Belongs to the acylphosphatase family
J4859_02885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
J4859_02895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J4859_02905	COG0148	phosphopyruvate hydratase activity
J4859_02925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
J4859_03035	COG2217	Heavy metal translocating P-type atpase
J4859_03040	COG0220	tRNA (guanine-N7-)-methyltransferase activity
J4859_03050	COG0252	asparaginase activity
J4859_03060	COG3875	lactate racemase activity
J4859_03105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
J4859_03115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J4859_03130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
J4859_03135	COG0805	protein transport
J4859_03140	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
J4859_03140	COG1754	DNA topoisomerase type I activity
J4859_03150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
J4859_03155	COG1774	PSP1 C-terminal conserved region
J4859_03160	COG0720	synthase
J4859_03170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
J4859_03175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4859_03175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4859_03180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
J4859_03185	COG0084	hydrolase, TatD family'
J4859_03190	COG1040	competence protein
J4859_03200	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
J4859_03210	COG2084	Dehydrogenase
J4859_03235	COG4988	ABC transporter
J4859_03240	COG1132	(ABC) transporter
J4859_03245	COG2832	Protein of unknown function (DUF454)
J4859_03305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
J4859_03305	COG0758	DNA mediated transformation
J4859_03330	COG0488	(ABC) transporter
J4859_03335	COG1979	alcohol dehydrogenase
J4859_03350	COG1136	(ABC) transporter
J4859_03430	COG0371	Dehydrogenase
J4859_03440	COG2195	Cleaves the N-terminal amino acid of tripeptides
J4859_03460	COG1164	Oligoendopeptidase f
J4859_03470	COG1028	Short-chain dehydrogenase reductase Sdr
J4859_03475	COG0673	inositol 2-dehydrogenase activity
J4859_03480	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
J4859_03580	COG1944	ATP diphosphatase activity
J4859_03690	COG3328	transposase activity
J4859_03755	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
J4859_03760	COG1028	Short-chain dehydrogenase reductase Sdr
J4859_03780	COG4974	Belongs to the 'phage' integrase family
J4859_03820	COG1349	DNA-binding transcription factor activity
J4859_03850	COG1349	DNA-binding transcription factor activity
J4859_03860	COG2801	Transposase and inactivated derivatives
J4859_03915	COG1063	alcohol dehydrogenase
J4859_03920	COG3716	PTS system mannose fructose sorbose family IID component
J4859_03925	COG3715	PTS system
J4859_03930	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4859_03970	COG0235	Class ii aldolase
J4859_03980	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
J4859_03990	COG3118	belongs to the thioredoxin family
J4859_04015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4859_04015	COG1263	PTS System
J4859_04020	COG1486	melibiose metabolic process
J4859_04095	COG1522	sequence-specific DNA binding
J4859_04095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4859_04100	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
J4859_04105	COG0813	purine-nucleoside phosphorylase activity
J4859_04115	COG3845	ABC transporter
J4859_04120	COG4603	Belongs to the binding-protein-dependent transport system permease family
J4859_04125	COG1079	Belongs to the binding-protein-dependent transport system permease family
J4859_04150	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
J4859_04200	COG1216	Glycosyl transferase, family 2
J4859_04200	COG1442	glycosyl transferase family 8
J4859_04210	COG1216	Glycosyl transferase, family 2
J4859_04220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
J4859_04225	COG1121	(ABC) transporter
J4859_04305	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
J4859_04325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
J4859_04350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
J4859_04370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4859_04375	COG1120	ATPase activity
J4859_04395	COG2272	Belongs to the type-B carboxylesterase lipase family
J4859_04400	COG2226	methyltransferase
J4859_04405	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
J4859_04410	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
J4859_04415	COG0352	thiamine-phosphate diphosphorylase activity
J4859_04420	COG0351	phosphomethylpyrimidine kinase
J4859_04420	COG0352	thiamine-phosphate diphosphorylase activity
J4859_04435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J4859_04440	COG1126	abc transporter atp-binding protein
J4859_04445	COG0765	amino acid transport
J4859_04450	COG0765	amino acid transport
J4859_04455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4859_04460	COG1472	Belongs to the glycosyl hydrolase 3 family
J4859_04600	COG1151	hydroxylamine reductase activity
J4859_04605	COG1573	uracil-dna glycosylase
J4859_04625	COG0515	serine threonine protein kinase
J4859_04655	COG0583	DNA-binding transcription factor activity
J4859_04690	COG3328	transposase activity
J4859_04705	COG3328	transposase activity
J4859_04740	COG1363	Peptidase, m42
J4859_04760	COG3041	Addiction module toxin RelE StbE family
J4859_04805	COG1216	Glycosyl transferase, family 2
J4859_04825	COG0402	S-adenosylhomocysteine deaminase activity
J4859_04830	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J4859_04830	COG0493	'glutamate synthase
J4859_04840	COG1529	Aldehyde oxidase and xanthine dehydrogenase
J4859_04845	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
J4859_04850	COG2080	2 iron, 2 sulfur cluster binding
J4859_04865	COG2721	sulfolactate sulfo-lyase activity
J4859_04870	COG1028	Short-chain dehydrogenase reductase Sdr
J4859_04875	COG0738	Major facilitator superfamily
J4859_04885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J4859_04910	COG2801	Transposase and inactivated derivatives
J4859_04935	COG1131	(ABC) transporter
J4859_05005	COG0235	Class ii aldolase
J4859_05010	COG3775	system Galactitol-specific IIC component
J4859_05020	COG2376	Dihydroxyacetone kinase
J4859_05040	COG2078	PFAM AMMECR1 domain protein
J4859_05040	COG3885	ferrous iron binding
J4859_05045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4859_05050	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J4859_05055	COG0549	Belongs to the carbamate kinase family
J4859_05075	COG0402	S-adenosylhomocysteine deaminase activity
J4859_05100	COG2826	transposase and inactivated derivatives, IS30 family
J4859_05115	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J4859_05115	COG3608	succinylglutamate desuccinylase aspartoacylase
J4859_05120	COG0709	Synthesizes selenophosphate from selenide and ATP
J4859_05125	COG3608	succinylglutamate desuccinylase aspartoacylase
J4859_05125	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
J4859_05130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
J4859_05150	COG0521	Mo-molybdopterin cofactor biosynthetic process
J4859_05170	COG1104	cysteine desulfurase activity
J4859_05195	COG3328	transposase activity
J4859_05250	COG1132	(ABC) transporter
J4859_05280	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J4859_05285	COG3973	AAA domain
J4859_05345	COG3328	transposase activity
J4859_05360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
J4859_05405	COG1929	Belongs to the glycerate kinase type-1 family
J4859_05445	COG4509	Sortase family
J4859_05460	COG2801	Transposase and inactivated derivatives
J4859_05475	COG0218	Necessary for normal cell division and for the maintenance of normal septation
J4859_05480	COG3973	AAA domain
J4859_05550	COG0386	Belongs to the glutathione peroxidase family
J4859_05560	COG1111	helicase
J4859_05560	COG1205	dead DEAH box helicase
J4859_05580	COG3775	system Galactitol-specific IIC component
J4859_05585	COG3414	Phosphotransferase system galactitol-specific IIB component
J4859_05600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
J4859_05625	COG0326	Molecular chaperone. Has ATPase activity
J4859_05635	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
J4859_05665	COG0306	phosphate transporter
J4859_05675	COG1362	aminopeptidase activity
J4859_05690	COG1918	ferrous iron import across plasma membrane
J4859_05690	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
J4859_05710	COG1120	ATPase activity
J4859_05715	COG4139	cobalamin transport
J4859_05740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
J4859_05750	COG1162	GTPase activity
J4859_05830	COG1028	Short-chain dehydrogenase reductase Sdr
J4859_05855	COG1120	ATPase activity
J4859_05860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
J4859_05915	COG1215	transferase activity, transferring glycosyl groups
J4859_05935	COG1088	dTDP-glucose 4,6-dehydratase activity
J4859_05965	COG1263	PTS System
J4859_05965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4859_05965	COG2190	(PTS) system
J4859_05970	COG1263	PTS System
J4859_05970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4859_05970	COG2190	(PTS) system
J4859_05975	COG2723	6-phospho-beta-galactosidase activity
J4859_06000	COG1254	Belongs to the acylphosphatase family
J4859_06005	COG1136	(ABC) transporter
J4859_06040	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
J4859_06045	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
J4859_06050	COG0351	phosphomethylpyrimidine kinase
J4859_06055	COG0352	thiamine-phosphate diphosphorylase activity
J4859_06060	COG0352	thiamine-phosphate diphosphorylase activity
J4859_06065	COG0352	thiamine-phosphate diphosphorylase activity
J4859_06070	COG3177	Filamentation induced by cAMP protein fic
J4859_06085	COG1846	Transcriptional regulator
J4859_06145	COG4115	mRNA cleavage
J4859_06190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4859_06200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J4859_06230	COG0583	DNA-binding transcription factor activity
J4859_06255	COG2171	N-acyltransferase activity
J4859_06275	COG1122	ATPase activity
J4859_06305	COG0791	NLP P60 protein
J4859_06325	COG1959	2 iron, 2 sulfur cluster binding
J4859_06330	COG0822	iron-sulfur transferase activity
J4859_06335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
J4859_06345	COG0719	Fe-S assembly protein
J4859_06350	COG0396	ATPase activity
J4859_06360	COG0154	amidase activity
J4859_06365	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
J4859_06370	COG1125	glycine betaine transport
J4859_06370	COG0517	IMP dehydrogenase activity
J4859_06375	COG1732	Glycine betaine
J4859_06400	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J4859_06405	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
J4859_06415	COG1950	PFAM Membrane protein of
J4859_06420	COG4496	protein, YerC YecD
J4859_06430	COG1074	ATP-dependent DNA helicase activity
J4859_06435	COG0587	DNA-directed DNA polymerase activity
J4859_06440	COG2033	superoxide reductase activity
J4859_06450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
J4859_06460	COG2255	four-way junction helicase activity
J4859_06470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
J4859_06510	COG0628	permease
J4859_06515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
J4859_06520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
J4859_06530	COG3715	PTS system
J4859_06535	COG3716	PTS system mannose fructose sorbose family IID component
J4859_06620	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
J4859_06625	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
J4859_06635	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
J4859_06645	COG0006	proline dipeptidase activity
J4859_06650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
J4859_06675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
J4859_06680	COG0497	DNA recombination
J4859_06685	COG0504	CTP synthase activity
J4859_06690	COG4974	Belongs to the 'phage' integrase family
J4859_06700	COG0275	rRNA processing
J4859_06710	COG0768	penicillin binding
J4859_06715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
J4859_06720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J4859_06725	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
J4859_06730	COG0772	Belongs to the SEDS family
J4859_06735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
J4859_06740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
J4859_06750	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
J4859_06755	COG1496	oxidoreductase activity
J4859_06760	COG1799	cell septum assembly
J4859_06765	COG0762	integral membrane protein
J4859_06780	COG1739	Uncharacterized protein family UPF0029
J4859_06800	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
J4859_06810	COG1263	PTS System
J4859_06810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4859_06815	COG0366	Alpha amylase catalytic
J4859_06850	COG1132	(ABC) transporter
J4859_06885	COG1609	Transcriptional regulator
J4859_06890	COG1621	beta-fructofuranosidase activity
J4859_07000	COG1968	undecaprenyl-diphosphatase activity
J4859_07005	COG0826	peptidase U32
J4859_07020	COG0210	DNA helicase
J4859_07025	COG0668	transmembrane transport
J4859_07030	COG1854	S-ribosylhomocysteine lyase activity
J4859_07035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
J4859_07040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
J4859_07085	COG0583	DNA-binding transcription factor activity
J4859_07090	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
J4859_07095	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
J4859_07100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J4859_07115	COG1045	serine acetyltransferase
J4859_07120	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
J4859_07130	COG0561	phosphatase activity
J4859_07180	COG0559	Belongs to the binding-protein-dependent transport system permease family
J4859_07215	COG1490	D-aminoacyl-tRNA deacylase activity
J4859_07220	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
J4859_07245	COG1151	hydroxylamine reductase activity
J4859_07275	COG3579	cysteine-type endopeptidase activity
J4859_07280	COG3579	cysteine-type endopeptidase activity
J4859_07285	COG0617	tRNA 3'-terminal CCA addition
J4859_07325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
J4859_07340	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
J4859_07345	COG0242	peptide deformylase activity
J4859_07350	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
J4859_07405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
J4859_07410	COG1302	Protein conserved in bacteria
J4859_07415	COG1461	Dihydroxyacetone kinase
J4859_07420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
J4859_07425	COG0742	ribosomal rna small subunit methyltransferase
J4859_07430	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
J4859_07445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
J4859_07455	COG0571	ribonuclease III activity
J4859_07460	COG1196	nuclear chromosome segregation
J4859_07465	COG0552	protein localization to endoplasmic reticulum
J4859_07470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
J4859_07500	COG1051	belongs to the nudix hydrolase family
J4859_07520	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4859_07525	COG1105	Belongs to the carbohydrate kinase PfkB family
J4859_07530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J4859_07550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
J4859_07615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
J4859_07620	COG0505	Belongs to the CarA family
J4859_07625	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
J4859_07635	COG0544	peptidyl-prolyl cis-trans isomerase activity
J4859_07640	COG0740	serine-type endopeptidase activity
J4859_07645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J4859_07665	COG0525	valine-tRNA ligase activity
J4859_07675	COG2759	Belongs to the formate--tetrahydrofolate ligase family
J4859_07685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
J4859_07690	COG0302	gtp cyclohydrolase
J4859_07695	COG0285	dihydrofolate synthase activity
J4859_07745	COG3328	transposase activity
J4859_07750	COG1464	Belongs to the NlpA lipoprotein family
J4859_07755	COG2011	ABC-type metal ion transport system permease component
J4859_07760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J4859_07765	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
J4859_07770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
J4859_07780	COG1609	Transcriptional regulator
J4859_07785	COG1879	ABC-type sugar transport system periplasmic component
J4859_07790	COG1129	ABC transporter
J4859_07795	COG4211	Belongs to the binding-protein-dependent transport system permease family
J4859_07800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
J4859_07845	COG1012	belongs to the aldehyde dehydrogenase family
J4859_07845	COG1454	alcohol dehydrogenase
J4859_07885	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
J4859_07890	COG2738	Putative neutral zinc metallopeptidase
J4859_07895	COG1570	exodeoxyribonuclease VII activity
J4859_07900	COG1722	exodeoxyribonuclease VII activity
J4859_07905	COG0537	adenosine 5'-monophosphoramidase activity
J4859_07930	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
J4859_07945	COG0493	'glutamate synthase
J4859_07975	COG1132	(ABC) transporter
J4859_07980	COG1132	(ABC) transporter
J4859_07990	COG2267	carboxylic ester hydrolase activity
J4859_07995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4859_07995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4859_08005	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
J4859_08055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4859_08060	COG0343	queuine tRNA-ribosyltransferase activity
J4859_08065	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J4859_08070	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
J4859_08080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
J4859_08085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4859_08105	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
J4859_08110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
J4859_08120	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
J4859_08145	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
J4859_08150	COG1447	Phosphotransferase system cellobiose-specific component IIA
J4859_08160	COG0546	phosphoglycolate phosphatase activity
J4859_08210	COG0018	arginyl-trna synthetase
J4859_08260	COG0083	homoserine kinase activity
J4859_08265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
J4859_08270	COG0460	homoserine dehydrogenase
J4859_08275	COG0527	aspartate kinase activity
J4859_08280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
J4859_08305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J4859_08310	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
J4859_08330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
J4859_08335	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
J4859_08340	COG0564	pseudouridine synthase activity
J4859_08345	COG1215	transferase activity, transferring glycosyl groups
J4859_08350	COG0516	GMP reductase activity
J4859_08350	COG0517	IMP dehydrogenase activity
J4859_08355	COG0495	leucyl-tRNA aminoacylation
J4859_08375	COG0779	Required for maturation of 30S ribosomal subunits
J4859_08380	COG0195	Participates in both transcription termination and antitermination
J4859_08385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
J4859_08390	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
J4859_08400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
J4859_08405	COG0196	riboflavin kinase activity
J4859_08410	COG0358	DNA primase activity
J4859_08415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
J4859_08470	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
J4859_08475	COG0540	Belongs to the ATCase OTCase family
J4859_08480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J4859_08490	COG0167	dihydroorotate dehydrogenase activity
J4859_08495	COG0284	orotidine-5'-phosphate decarboxylase activity
J4859_08505	COG0194	GDP metabolic process
J4859_08515	COG0301	tRNA thio-modification
J4859_08520	COG1555	photosystem II stabilization
J4859_08520	COG1596	polysaccharide export
J4859_08525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
J4859_08535	COG0268	Binds directly to 16S ribosomal RNA
J4859_08540	COG0481	GTPase activity
J4859_08545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
J4859_08550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
J4859_08555	COG0484	heat shock protein binding
J4859_08560	COG0484	heat shock protein binding
J4859_08565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J4859_08570	COG1702	phosphate starvation-inducible protein PhoH
J4859_08575	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
J4859_08580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
J4859_08585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
J4859_08590	COG1381	Involved in DNA repair and RecF pathway recombination
J4859_08595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
J4859_08600	COG1185	polyribonucleotide nucleotidyltransferase activity
J4859_08605	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
J4859_08610	COG1674	ftsk spoiiie
J4859_08620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J4859_08635	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
J4859_08645	COG1418	mRNA catabolic process
J4859_08655	COG2359	stage V sporulation protein S
J4859_08660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
J4859_08665	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
J4859_08670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
J4859_08675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
J4859_08685	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J4859_08690	COG0756	dUTP diphosphatase activity
J4859_08695	COG2252	PERMEase
J4859_08720	COG0038	chloride channel
J4859_08725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
J4859_08740	COG0251	oxidation-reduction process
J4859_08750	COG1686	Belongs to the peptidase S11 family
J4859_08755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
J4859_08770	COG0058	SHG alpha-glucan phosphorylase activity
J4859_08775	COG1640	4-alpha-glucanotransferase
J4859_08780	COG3842	ATPase activity
J4859_08800	COG2188	Transcriptional regulator
J4859_08860	COG3328	transposase activity
J4859_08890	COG2826	transposase and inactivated derivatives, IS30 family
J4859_08975	COG1335	isochorismatase
J4859_09010	COG1132	(ABC) transporter
J4859_09015	COG1132	(ABC) transporter
J4859_09020	COG0488	(ABC) transporter
J4859_09025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
J4859_09040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
J4859_09045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
J4859_09055	COG1160	GTP binding
J4859_09060	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
J4859_09070	COG0588	phosphoglycerate mutase activity
J4859_09075	COG1187	pseudouridine synthase activity
J4859_09080	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
J4859_09090	COG1994	Peptidase M50
J4859_09100	COG0488	(ABC) transporter
J4859_09120	COG1438	arginine binding
J4859_09125	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
J4859_09130	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
J4859_09135	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
J4859_09140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
J4859_09155	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J4859_09175	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J4859_09175	COG2755	lipolytic protein G-D-S-L family
J4859_09195	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
J4859_09205	COG0157	Belongs to the NadC ModD family
J4859_09210	COG1827	regulation of RNA biosynthetic process
J4859_09235	COG1131	(ABC) transporter
J4859_09275	COG0095	Lipoate-protein ligase
J4859_09280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
J4859_09335	COG0442	prolyl-tRNA aminoacylation
J4859_09340	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
J4859_09345	COG0750	zinc metalloprotease
J4859_09355	COG4589	Belongs to the CDS family
J4859_09360	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
J4859_09370	COG0528	UMP kinase activity
J4859_09375	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
J4859_09380	COG0052	Belongs to the universal ribosomal protein uS2 family
J4859_09400	COG1032	radical SAM domain protein
J4859_09405	COG4974	Belongs to the 'phage' integrase family
J4859_09410	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
J4859_09425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
J4859_09430	COG0335	large ribosomal subunit rRNA binding
J4859_09440	COG0574	Belongs to the PEP-utilizing enzyme family
J4859_09440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
J4859_09445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
J4859_09455	COG0752	glycyl-tRNA synthetase alpha subunit
J4859_09460	COG0681	Belongs to the peptidase S26 family
J4859_09465	COG0336	Belongs to the RNA methyltransferase TrmD family
J4859_09470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
J4859_09525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
J4859_09530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
J4859_09535	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
J4859_09540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
J4859_09545	COG0261	This protein binds to 23S rRNA in the presence of protein L20
J4859_09555	COG0772	Belongs to the SEDS family
J4859_09560	COG0768	penicillin binding
J4859_09575	COG1077	Cell shape determining protein MreB Mrl
J4859_09585	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
J4859_09595	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
J4859_09600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J4859_09610	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
J4859_09615	COG0287	Prephenate dehydrogenase
J4859_09620	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
J4859_09625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
J4859_09630	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
J4859_09635	COG0077	Prephenate dehydratase
J4859_09635	COG1605	Chorismate mutase
J4859_09640	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
J4859_09650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
J4859_09655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
J4859_09660	COG0180	Tryptophanyl-tRNA synthetase
J4859_09665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
J4859_09670	COG3842	ATPase activity
J4859_09700	COG3958	Transketolase
J4859_09705	COG3959	Transketolase, thiamine diphosphate binding domain
J4859_09710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
J4859_09720	COG3037	sugar-specific permease SgaT UlaA
J4859_09725	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4859_09730	COG1349	DNA-binding transcription factor activity
J4859_09750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
J4859_09810	COG0424	maF-like protein
J4859_09815	COG3191	aminopeptidase activity
J4859_09820	COG1434	Gram-negative-bacterium-type cell wall biogenesis
J4859_09835	COG0280	phosphate acetyltransferase
J4859_09840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
J4859_09850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
J4859_09855	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
J4859_09860	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
J4859_09870	COG0205	6-phosphofructokinase activity
J4859_09875	COG0640	Transcriptional regulator
J4859_09885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
J4859_09890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
J4859_09895	COG1278	Cold shock
J4859_09905	COG1136	(ABC) transporter
J4859_09920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
J4859_09950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J4859_10010	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
J4859_10015	COG0583	DNA-binding transcription factor activity
J4859_10060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
J4859_10065	COG1696	Membrane protein involved in D-alanine export
J4859_10070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
J4859_10085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J4859_10110	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
J4859_10120	COG0646	methionine synthase
J4859_10120	COG1410	methionine synthase
J4859_10160	COG0217	transcriptional regulatory protein
J4859_10190	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
J4859_10200	COG0826	peptidase U32
J4859_10205	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
J4859_10210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
J4859_10250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
J4859_10255	COG0116	Belongs to the methyltransferase superfamily
J4859_10255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J4859_10265	COG3158	transport of potassium into the cell
J4859_10280	COG0561	phosphatase activity
J4859_10335	COG0514	ATP-dependent DNA helicase (RecQ)
J4859_10340	COG0514	ATP-dependent DNA helicase (RecQ)
J4859_10345	COG1216	Glycosyl transferase, family 2
J4859_10350	COG1307	EDD domain protein, DegV family
J4859_10375	COG2188	Transcriptional regulator
J4859_10420	COG0072	phenylalanine-tRNA ligase activity
J4859_10420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
J4859_10425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
J4859_10445	COG2267	carboxylic ester hydrolase activity
J4859_10455	COG1940	carbohydrate kinase activity
J4859_10470	COG2801	Transposase and inactivated derivatives
J4859_10550	COG2213	PTS system mannitol-specific
J4859_10550	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
J4859_10555	COG0436	Aminotransferase
J4859_10560	COG0436	Aminotransferase
J4859_10570	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
J4859_10570	COG1328	CTP reductase activity
J4859_10580	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J4859_10590	COG1297	OPT oligopeptide transporter protein
J4859_10650	COG1486	melibiose metabolic process
J4859_10655	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4859_10655	COG1263	PTS System
J4859_10660	COG1737	Transcriptional regulator
J4859_10680	COG0561	phosphatase activity
J4859_10690	COG3716	PTS system mannose fructose sorbose family IID component
J4859_10695	COG3715	PTS system
J4859_10735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4859_10735	COG1263	PTS System
J4859_10735	COG2190	(PTS) system
J4859_10795	COG4166	transmembrane transport
J4859_10800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4859_10800	COG2190	(PTS) system
J4859_10800	COG1263	PTS System
J4859_10810	COG3250	beta-galactosidase activity
J4859_10815	COG1028	Short-chain dehydrogenase reductase Sdr
J4859_10845	COG0577	efflux transmembrane transporter activity
J4859_10845	COG1136	(ABC) transporter
J4859_10915	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
J4859_10920	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
J4859_10930	COG1263	PTS System
J4859_10930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4859_10930	COG2190	(PTS) system
J4859_10935	COG2723	6-phospho-beta-galactosidase activity
J4859_10965	COG3093	addiction module antidote protein HigA
J4859_11005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
J4859_11025	COG0745	RESPONSE REGULATOR receiver
J4859_11030	COG2205	protein histidine kinase activity
J4859_11035	COG1136	(ABC) transporter
J4859_11040	COG0577	efflux transmembrane transporter activity
J4859_11050	COG3328	transposase activity
J4859_11070	COG2188	Transcriptional regulator
J4859_11080	COG2222	sugar isomerase
J4859_11085	COG3716	PTS system mannose fructose sorbose family IID component
J4859_11090	COG3715	PTS system
J4859_11095	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4859_11145	COG3547	Transposase (IS116 IS110 IS902 family)
J4859_11160	COG0602	queuosine metabolic process
J4859_11170	COG2816	NAD+ diphosphatase activity
J4859_11175	COG0560	Phosphoserine phosphatase
J4859_11175	COG3830	Belongs to the UPF0237 family
J4859_11195	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
J4859_11195	COG2755	lipolytic protein G-D-S-L family
J4859_11210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
J4859_11215	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
J4859_11230	COG0017	Asparaginyl-tRNA synthetase
J4859_11235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
J4859_11240	COG0114	fumarate hydratase activity
J4859_11260	COG0281	malic enzyme
J4859_11275	COG3039	Transposase
J4859_11285	COG3041	Addiction module toxin RelE StbE family
J4859_11320	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
J4859_11325	COG0297	glycogen (starch) synthase activity
J4859_11410	COG0159	tryptophan synthase activity
J4859_11420	COG0135	phosphoribosylanthranilate isomerase activity
J4859_11425	COG0134	indole-3-glycerol-phosphate synthase activity
J4859_11435	COG0512	Glutamine amidotransferase of anthranilate synthase
J4859_11435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
J4859_11465	COG4624	Iron only hydrogenase large subunit, C-terminal domain
J4859_11465	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
J4859_11480	COG0482	sulfurtransferase activity
J4859_11490	COG1053	succinate dehydrogenase
J4859_11500	COG3039	Transposase
J4859_11555	COG1366	Belongs to the anti-sigma-factor antagonist family
J4859_11660	COG1944	ATP diphosphatase activity
J4859_11735	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
J4859_11750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
J4859_11755	COG1481	regulation of sporulation
J4859_11760	COG1660	Displays ATPase and GTPase activities
J4859_11765	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
J4859_11775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J4859_11790	COG4172	Belongs to the ABC transporter superfamily
J4859_11795	COG0444	Belongs to the ABC transporter superfamily
J4859_11810	COG0322	excinuclease ABC activity
J4859_11825	COG0107	imidazoleglycerol-phosphate synthase activity
J4859_11830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
J4859_11835	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
J4859_11840	COG0131	Imidazoleglycerol-phosphate dehydratase
J4859_11845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
J4859_11850	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
J4859_11855	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
J4859_11865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
J4859_11870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
J4859_11880	COG2081	HI0933 family
J4859_11885	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
J4859_11890	COG0556	nucleotide-excision repair
J4859_11910	COG2195	Cleaves the N-terminal amino acid of tripeptides
J4859_11915	COG0747	negative chemotaxis
J4859_11920	COG4608	Belongs to the ABC transporter superfamily
J4859_11925	COG0444	Belongs to the ABC transporter superfamily
J4859_11930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
J4859_11940	COG0747	negative chemotaxis
J4859_11945	COG0539	negative regulation of cytoplasmic translation
J4859_11960	COG0328	RNA-DNA hybrid ribonuclease activity
J4859_12010	COG2217	Heavy metal translocating P-type atpase
J4859_12015	COG1937	Protein conserved in bacteria
J4859_12025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
J4859_12030	COG0745	RESPONSE REGULATOR receiver
J4859_12035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
J4859_12040	COG1126	abc transporter atp-binding protein
J4859_12045	COG0765	amino acid transport
J4859_12055	COG0174	glutamine synthetase
J4859_12065	COG0588	phosphoglycerate mutase activity
J4859_12075	COG1482	cell wall glycoprotein biosynthetic process
J4859_12085	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
J4859_12085	COG1918	ferrous iron import across plasma membrane
J4859_12100	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
J4859_12115	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
J4859_12165	COG0800	Aldolase
J4859_12175	COG1802	Transcriptional regulator
J4859_12180	COG0124	histidyl-tRNA synthetase
J4859_12185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
J4859_12200	COG0039	L-malate dehydrogenase activity
J4859_12220	COG1392	Phosphate transport regulator
J4859_12225	COG0306	phosphate transporter
J4859_12250	COG0494	nUDIX hydrolase
J4859_12255	COG0488	(ABC) transporter
J4859_12260	COG2239	Acts as a magnesium transporter
J4859_12275	COG1122	ATPase activity
J4859_12300	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
J4859_12305	COG1518	maintenance of DNA repeat elements
J4859_12310	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
J4859_12350	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
J4859_12375	COG0071	Belongs to the small heat shock protein (HSP20) family
J4859_12425	COG3475	LICD family
J4859_12440	COG0697	spore germination
J4859_12445	COG4750	Nucleotidyl transferase
J4859_12465	COG1473	amidohydrolase
J4859_12475	COG2826	transposase and inactivated derivatives, IS30 family
J4859_12535	COG0681	Belongs to the peptidase S26 family
J4859_12570	COG1121	(ABC) transporter
J4859_12575	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
J4859_12610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
J4859_12645	COG2059	Chromate
J4859_12650	COG2873	o-acetylhomoserine
J4859_12655	COG2873	o-acetylhomoserine
J4859_12665	COG0175	sulfate reduction
J4859_12675	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
J4859_12725	COG4120	Belongs to the binding-protein-dependent transport system permease family
J4859_12730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
J4859_12735	COG3956	TIGRFAM MazG family protein
J4859_12750	COG0698	ribose 5-phosphate isomerase
J4859_12785	COG1609	Transcriptional regulator
J4859_12815	COG2190	(PTS) system
J4859_12815	COG1263	PTS System
J4859_12815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
J4859_12820	COG1609	Transcriptional regulator
J4859_12830	COG3959	Transketolase, thiamine diphosphate binding domain
J4859_12835	COG3958	Transketolase
J4859_12840	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
J4859_12895	COG1131	(ABC) transporter
J4859_12925	COG1476	TRANSCRIPTIONal
J4859_12990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
J4859_13075	COG0436	Aminotransferase
J4859_13080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
J4859_13090	COG2848	UPF0210 protein
J4859_13100	COG0812	UDP-N-acetylmuramate dehydrogenase activity
J4859_13115	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
J4859_13120	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
J4859_13125	COG0390	transport system, permease component
J4859_13130	COG4619	ABC transporter
J4859_13140	COG0561	phosphatase activity
J4859_13170	COG0024	Methionine aminopeptidase
J4859_13180	COG4464	protein tyrosine phosphatase activity
J4859_13205	COG0066	3-isopropylmalate dehydratase activity
J4859_13210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
J4859_13225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
J4859_13230	COG0028	Belongs to the TPP enzyme family
J4859_13240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
J4859_13275	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
J4859_13335	COG3328	transposase activity
J4859_13340	COG3328	transposase activity
J4859_13345	COG1349	DNA-binding transcription factor activity
J4859_13385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
J4859_13445	COG1959	2 iron, 2 sulfur cluster binding
J4859_13460	COG1063	alcohol dehydrogenase
J4859_13470	COG0519	Catalyzes the synthesis of GMP from XMP
J4859_13535	COG2723	6-phospho-beta-galactosidase activity
J4859_13590	COG0371	Dehydrogenase
J4859_13625	COG1472	Belongs to the glycosyl hydrolase 3 family
J4859_13630	COG3250	beta-galactosidase activity
J4859_13680	COG3189	MarR family transcriptional regulator
J4859_13690	COG0789	Transcriptional regulator
J4859_13825	COG0519	Catalyzes the synthesis of GMP from XMP
J4859_13950	COG0542	response to heat
J4859_13985	COG0464	growth
J4859_14000	COG1131	(ABC) transporter
J4859_14025	COG1725	Transcriptional regulator
J4859_14045	COG1132	(ABC) transporter
J4859_14080	COG0745	RESPONSE REGULATOR receiver
J4859_14085	COG5002	protein histidine kinase activity
J4859_14095	COG4974	Belongs to the 'phage' integrase family
J4859_14105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
J4859_14105	COG0519	Catalyzes the synthesis of GMP from XMP
J4859_14110	COG1316	TRANSCRIPTIONal
J4859_14130	COG0459	protein refolding
J4859_14135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
J4859_14145	COG1126	abc transporter atp-binding protein
J4859_14150	COG0765	amino acid transport
J4859_14165	COG0802	atpase or kinase
J4859_14170	COG1573	uracil-dna glycosylase
J4859_14175	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
J4859_14180	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
J4859_14180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
J4859_14185	COG0736	holo-[acyl-carrier-protein] synthase activity
J4859_14190	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
J4859_14195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
J4859_14225	COG3328	transposase activity
J4859_14340	COG4842	Belongs to the WXG100 family
J4859_14365	COG0515	serine threonine protein kinase
J4859_14365	COG2815	serine threonine protein kinase
J4859_14370	COG0515	serine threonine protein kinase
J4859_14370	COG2815	serine threonine protein kinase
J4859_14420	COG2723	6-phospho-beta-galactosidase activity
J4859_14430	COG2723	6-phospho-beta-galactosidase activity
J4859_14435	COG0656	L-ascorbic acid biosynthetic process
J4859_14440	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
J4859_14440	COG0493	'glutamate synthase
J4859_14445	COG2084	Dehydrogenase
J4859_14450	COG1929	Belongs to the glycerate kinase type-1 family
J4859_14455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
J4859_14460	COG4948	Mandelate Racemase Muconate Lactonizing
J4859_14465	COG4948	Mandelate Racemase Muconate Lactonizing
J4859_14470	COG3835	regulator
J4859_14475	COG2851	Citrate transporter
J4859_14485	COG2721	sulfolactate sulfo-lyase activity
J4859_14510	COG3328	transposase activity
J4859_14525	COG3547	Transposase (IS116 IS110 IS902 family)
J4859_14540	COG2161	toxin-antitoxin pair type II binding
J4859_14615	COG1773	rubredoxin
J4859_14625	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
J4859_14635	COG0557	exoribonuclease II activity
J4859_14640	COG2177	Part of the ABC transporter FtsEX involved in
J4859_14645	COG2884	Cell division ATP-binding protein ftsE
J4859_14650	COG3958	Transketolase
J4859_14655	COG3959	Transketolase, thiamine diphosphate binding domain
J4859_14660	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
J4859_14665	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
J4859_14670	COG0653	protein targeting
J4859_14710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
J4859_14725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
J4859_14730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
J4859_14735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
J4859_14740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
J4859_14745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
J4859_14750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J4859_14755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
J4859_14760	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
J4859_14780	COG0129	dihydroxy-acid dehydratase activity
J4859_14785	COG2610	gluconate transmembrane transporter activity
J4859_14790	COG2186	Transcriptional regulator
J4859_14805	COG3547	Transposase (IS116 IS110 IS902 family)
J4859_14830	COG3732	PTS system glucitol sorbitol-specific
J4859_14835	COG3730	PTS system glucitol sorbitol-specific
J4859_14895	COG0561	phosphatase activity
J4859_14905	COG2235	arginine
J4859_14925	COG2801	Transposase and inactivated derivatives
J4859_14940	COG2186	Transcriptional regulator
J4859_14945	COG0191	fructose-bisphosphate aldolase activity
J4859_14960	COG3775	system Galactitol-specific IIC component
J4859_14965	COG1070	Carbohydrate kinase
J4859_14980	COG0698	ribose 5-phosphate isomerase
J4859_14990	COG2890	protein-(glutamine-N5) methyltransferase activity
J4859_14995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
J4859_15005	COG0254	rRNA binding
J4859_15010	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
J4859_15025	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
J4859_15035	COG0708	Exodeoxyribonuclease III
J4859_15050	COG0436	Aminotransferase
J4859_15055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
J4859_15060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
J4859_15060	COG0037	tRNA processing
J4859_15065	COG0590	tRNA wobble adenosine to inosine editing
J4859_15065	COG0037	tRNA processing
J4859_15070	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
J4859_15195	COG2186	Transcriptional regulator
J4859_15225	COG1136	(ABC) transporter
J4859_15225	COG0577	efflux transmembrane transporter activity
J4859_15240	COG0071	Belongs to the small heat shock protein (HSP20) family
J4859_15255	COG0515	serine threonine protein kinase
J4859_15255	COG2815	serine threonine protein kinase
J4859_15260	COG2801	Transposase and inactivated derivatives
J4859_15275	COG0542	response to heat
J4859_15280	COG0789	Transcriptional regulator
J4859_15285	COG0484	heat shock protein binding
J4859_15290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
J4859_15295	COG0443	Heat shock 70 kDa protein
J4859_15300	COG0622	Phosphoesterase
J4859_15340	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
J4859_15345	COG1268	BioY protein
J4859_15365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
J4859_15370	COG0590	tRNA wobble adenosine to inosine editing
J4859_15375	COG1105	Belongs to the carbohydrate kinase PfkB family
J4859_15385	COG1704	LemA family
J4859_15410	COG1253	flavin adenine dinucleotide binding
J4859_15415	COG0426	domain, Protein
J4859_15420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
J4859_15430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
J4859_15435	COG0071	Belongs to the small heat shock protein (HSP20) family
J4859_15445	COG1472	Belongs to the glycosyl hydrolase 3 family
J4859_15450	COG1447	Phosphotransferase system cellobiose-specific component IIA
J4859_15455	COG0586	Pfam SNARE associated Golgi protein
J4859_15540	COG1349	DNA-binding transcription factor activity
J4859_15565	COG0698	ribose 5-phosphate isomerase
J4859_15570	COG3775	system Galactitol-specific IIC component
J4859_15575	COG3414	Phosphotransferase system galactitol-specific IIB component
J4859_15580	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
J4859_15635	COG1216	Glycosyl transferase, family 2
J4859_15740	COG3275	phosphorelay sensor kinase activity
J4859_15755	COG0671	phosphoesterase, PA-phosphatase related
J4859_15780	COG3547	Transposase (IS116 IS110 IS902 family)
J4859_15790	COG2376	Dihydroxyacetone kinase
J4859_15805	COG2376	Dihydroxyacetone kinase
J4859_15825	COG3775	system Galactitol-specific IIC component