locus-tag	class	description
CP97_00025	COG2267	carboxylic ester hydrolase activity
CP97_00040	COG0582	viral genome integration into host DNA
CP97_00055	COG0789	Transcriptional regulator
CP97_00070	COG4771	TonB-dependent receptor
CP97_00075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CP97_00125	COG0069	glutamate synthase activity
CP97_00135	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_00140	COG2351	hydroxyisourate hydrolase activity
CP97_00170	COG1285	pathogenesis
CP97_00200	COG4191	Histidine kinase
CP97_00205	COG4566	intracellular signal transduction
CP97_00220	COG2860	membrane
CP97_00225	COG0583	DNA-binding transcription factor activity
CP97_00230	COG1741	Belongs to the pirin family
CP97_00235	COG0431	NADPH-dependent FMN reductase
CP97_00240	COG2353	YceI-like domain
CP97_00245	COG3384	dioxygenase
CP97_00520	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CP97_00540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP97_00620	COG4227	nucleotidyltransferase activity
CP97_00660	COG3293	Transposase
CP97_00680	COG1475	DNA binding
CP97_00691	COG4974	Belongs to the 'phage' integrase family
CP97_00715	COG0741	lytic transglycosylase activity
CP97_00745	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CP97_00750	COG0318	PFAM AMP-dependent synthetase and ligase
CP97_00775	COG2070	2-Nitropropane dioxygenase
CP97_00780	COG0527	aspartate kinase activity
CP97_00785	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CP97_00800	COG1393	Belongs to the ArsC family
CP97_00825	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CP97_00835	COG0217	transcriptional regulatory protein
CP97_00840	COG3750	Belongs to the UPF0335 family
CP97_00850	COG0469	pyruvate kinase activity
CP97_00870	COG2095	MarC family integral membrane protein
CP97_00880	COG0762	integral membrane protein
CP97_00885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CP97_00920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CP97_00960	COG1131	(ABC) transporter
CP97_00995	COG0519	Catalyzes the synthesis of GMP from XMP
CP97_00995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CP97_01005	COG0628	permease
CP97_01030	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP97_01040	COG1960	acyl-CoA dehydrogenase activity
CP97_01055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CP97_01060	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CP97_01080	COG0352	thiamine-phosphate diphosphorylase activity
CP97_01085	COG1674	ftsk spoiiie
CP97_01090	COG0189	ligase activity
CP97_01090	COG4067	protein conserved in archaea
CP97_01095	COG0189	ligase activity
CP97_01115	COG0686	Belongs to the AlaDH PNT family
CP97_01150	COG2205	protein histidine kinase activity
CP97_01155	COG0433	COG0433 Predicted ATPase
CP97_01165	COG0436	Aminotransferase
CP97_01170	COG0564	pseudouridine synthase activity
CP97_01180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CP97_01200	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CP97_01210	COG0514	ATP-dependent DNA helicase (RecQ)
CP97_01225	COG3186	Phenylalanine-4-hydroxylase
CP97_01235	COG1968	undecaprenyl-diphosphatase activity
CP97_01240	COG3590	peptidase
CP97_01245	COG1132	(ABC) transporter
CP97_01270	COG0297	glycogen (starch) synthase activity
CP97_01280	COG0067	glutamate synthase
CP97_01280	COG0070	glutamate synthase
CP97_01280	COG0069	glutamate synthase activity
CP97_01295	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CP97_01300	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CP97_01340	COG2264	protein methyltransferase activity
CP97_01355	COG1132	(ABC) transporter
CP97_01485	COG0495	leucyl-tRNA aminoacylation
CP97_01500	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_01520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CP97_01525	COG0739	heme binding
CP97_01530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CP97_01535	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CP97_01550	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CP97_01560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP97_01575	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CP97_01580	COG4152	abc transporter atp-binding protein
CP97_01605	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CP97_01620	COG0776	regulation of translation
CP97_01625	COG2188	Transcriptional regulator
CP97_01630	COG3104	oligopeptide transport
CP97_01635	COG1228	amidohydrolase
CP97_01650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CP97_01660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP97_01665	COG0138	bifunctional purine biosynthesis protein purh
CP97_01675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CP97_01695	COG1473	amidohydrolase
CP97_01725	COG0667	Aldo Keto reductase
CP97_01745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP97_01750	COG0457	Tetratricopeptide repeat
CP97_01755	COG4771	TonB-dependent receptor
CP97_01765	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_01815	COG3275	phosphorelay sensor kinase activity
CP97_01820	COG3279	Response regulator of the LytR AlgR family
CP97_01835	COG0590	tRNA wobble adenosine to inosine editing
CP97_01840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CP97_01860	COG1570	exodeoxyribonuclease VII activity
CP97_01865	COG0151	Belongs to the GarS family
CP97_01870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP97_01890	COG0316	Belongs to the HesB IscA family
CP97_01895	COG2151	metal-sulfur cluster biosynthetic enzyme
CP97_01900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CP97_01910	COG0719	Fe-S assembly protein
CP97_01915	COG0396	ATPase activity
CP97_01925	COG0719	Fe-S assembly protein
CP97_01940	COG0167	dihydroorotate dehydrogenase activity
CP97_01945	COG0405	Gamma-glutamyltransferase
CP97_01950	COG1022	Amp-dependent synthetase and ligase
CP97_01960	COG2022	thiamine diphosphate biosynthetic process
CP97_01970	COG1612	heme a metabolic process
CP97_01975	COG1324	tolerance protein
CP97_01980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CP97_01985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CP97_01990	COG0784	Response regulator, receiver
CP97_02015	COG3275	phosphorelay sensor kinase activity
CP97_02025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CP97_02055	COG0316	Belongs to the HesB IscA family
CP97_02065	COG3409	Peptidoglycan-binding domain 1 protein
CP97_02065	COG3773	Cell wall hydrolase
CP97_02085	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CP97_02090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CP97_02095	COG0237	dephospho-CoA kinase activity
CP97_02100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CP97_02105	COG0424	maF-like protein
CP97_02110	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CP97_02115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CP97_02120	COG1981	membrane
CP97_02125	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CP97_02145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CP97_02150	COG0445	tRNA wobble uridine modification
CP97_02155	COG0357	Ribosomal RNA small subunit methyltransferase G
CP97_02175	COG1956	GAF domain-containing protein
CP97_02205	COG1329	Transcriptional regulator
CP97_02210	COG1295	ribonuclease BN
CP97_02215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CP97_02220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CP97_02230	COG0739	heme binding
CP97_02235	COG0113	porphobilinogen synthase activity
CP97_02250	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CP97_02255	COG1793	dna ligase
CP97_02280	COG1063	alcohol dehydrogenase
CP97_02290	COG0438	transferase activity, transferring glycosyl groups
CP97_02305	COG0739	heme binding
CP97_02310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CP97_02315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CP97_02320	COG0799	negative regulation of ribosome biogenesis
CP97_02325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CP97_02335	COG0793	Belongs to the peptidase S41A family
CP97_02345	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CP97_02355	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CP97_02360	COG1295	ribonuclease BN
CP97_02365	COG0484	heat shock protein binding
CP97_02370	COG0259	pyridoxamine-phosphate oxidase activity
CP97_02395	COG0482	sulfurtransferase activity
CP97_02415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CP97_02425	COG2733	membrane
CP97_02455	COG0045	succinate-CoA ligase (ADP-forming) activity
CP97_02460	COG0483	inositol monophosphate 1-phosphatase activity
CP97_02470	COG1253	flavin adenine dinucleotide binding
CP97_02480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CP97_02485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CP97_02490	COG0196	riboflavin kinase activity
CP97_02505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CP97_02515	COG0588	phosphoglycerate mutase activity
CP97_02525	COG3665	Urea carboxylase-associated protein
CP97_02580	COG0308	aminopeptidase N
CP97_02585	COG1496	oxidoreductase activity
CP97_02600	COG2857	Cytochrome c1
CP97_02600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CP97_02605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CP97_02625	COG0582	viral genome integration into host DNA
CP97_02655	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CP97_02660	COG1192	Involved in chromosome partitioning
CP97_02685	COG1201	RNA secondary structure unwinding
CP97_02735	COG1494	fructose-1,6-bisphosphatase
CP97_02750	COG0483	inositol monophosphate 1-phosphatase activity
CP97_02755	COG3920	Histidine kinase
CP97_02760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CP97_02765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CP97_02770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CP97_02775	COG0072	phenylalanine-tRNA ligase activity
CP97_02790	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CP97_02805	COG0347	Belongs to the P(II) protein family
CP97_02810	COG0004	ammonium transporteR
CP97_02815	COG2885	chlorophyll binding
CP97_02820	COG1278	Cold shock
CP97_02825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CP97_02830	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CP97_02845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CP97_02850	COG2032	superoxide dismutase activity
CP97_02920	COG4695	Portal protein
CP97_02940	COG0156	8-amino-7-oxononanoate synthase activity
CP97_03005	COG3483	tryptophan 2,3-dioxygenase activity
CP97_03045	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CP97_03050	COG0281	malic enzyme
CP97_03050	COG0280	phosphate acetyltransferase
CP97_03055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CP97_03095	COG2146	nitrite reductase [NAD(P)H] activity
CP97_03105	COG0318	PFAM AMP-dependent synthetase and ligase
CP97_03115	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CP97_03140	COG3971	2-oxopent-4-enoate hydratase activity
CP97_03145	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CP97_03150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP97_03190	COG1595	DNA-templated transcription, initiation
CP97_03200	COG0729	surface antigen
CP97_03205	COG1295	ribonuclease BN
CP97_03205	COG1959	2 iron, 2 sulfur cluster binding
CP97_03210	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CP97_03215	COG0730	response to heat
CP97_03220	COG0745	RESPONSE REGULATOR receiver
CP97_03245	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CP97_03250	COG1137	ATPase activity
CP97_03260	COG0668	transmembrane transport
CP97_03270	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CP97_03275	COG0124	histidyl-tRNA synthetase
CP97_03280	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CP97_03285	COG2890	protein-(glutamine-N5) methyltransferase activity
CP97_03295	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CP97_03300	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CP97_03305	COG2311	Membrane
CP97_03315	COG1215	transferase activity, transferring glycosyl groups
CP97_03325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CP97_03330	COG0668	transmembrane transport
CP97_03335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP97_03335	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CP97_03340	COG3206	protein involved in exopolysaccharide biosynthesis
CP97_03340	COG0489	protein tyrosine kinase activity
CP97_03360	COG3667	copper resistance
CP97_03365	COG2132	Multicopper oxidase
CP97_03370	COG1937	Protein conserved in bacteria
CP97_03400	COG0459	protein refolding
CP97_03405	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CP97_03410	COG0534	Mate efflux family protein
CP97_03425	COG0222	ribosome binding
CP97_03430	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CP97_03440	COG3655	Transcriptional regulator
CP97_03450	COG0085	RNA polymerase activity
CP97_03455	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CP97_03470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CP97_03470	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CP97_03485	COG0717	Belongs to the dCTP deaminase family
CP97_03520	COG2884	Cell division ATP-binding protein ftsE
CP97_03535	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CP97_03540	COG0076	glutamate decarboxylase activity
CP97_03575	COG1024	Enoyl-CoA hydratase
CP97_03580	COG0287	Prephenate dehydrogenase
CP97_03585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP97_03590	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CP97_03595	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CP97_03595	COG2813	Specifically methylates the guanine in position
CP97_03605	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CP97_03610	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CP97_03630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP97_03635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CP97_03650	COG0330	HflC and HflK could
CP97_03655	COG0489	protein tyrosine kinase activity
CP97_03665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CP97_03675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CP97_03675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CP97_03680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CP97_03715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CP97_03755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CP97_03755	COG1213	nucleotidyl transferase
CP97_03770	COG1260	myo-inositol-1-phosphate synthase
CP97_03775	COG1213	nucleotidyl transferase
CP97_03775	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CP97_03790	COG0800	Aldolase
CP97_03795	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_03800	COG2271	Major facilitator Superfamily
CP97_03820	COG2186	Transcriptional regulator
CP97_03885	COG4964	Belongs to the GSP D family
CP97_03935	COG1218	3'(2'),5'-bisphosphate nucleotidase
CP97_03945	COG0175	sulfate reduction
CP97_03955	COG1482	cell wall glycoprotein biosynthetic process
CP97_03985	COG1758	RNA polymerase activity
CP97_03990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CP97_04000	COG0305	Participates in initiation and elongation during chromosome replication
CP97_04005	COG5328	Belongs to the UPF0262 family
CP97_04020	COG2866	Carboxypeptidase
CP97_04035	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CP97_04055	COG0606	chelatase, subunit chli
CP97_04070	COG0594	ribonuclease P activity
CP97_04075	COG0706	membrane insertase activity
CP97_04080	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CP97_04095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CP97_04100	COG1301	dicarboxylic acid transport
CP97_04120	COG0501	Belongs to the peptidase M48B family
CP97_04125	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CP97_04130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CP97_04140	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CP97_04145	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CP97_04150	COG0268	Binds directly to 16S ribosomal RNA
CP97_04155	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CP97_04160	COG2226	methyltransferase
CP97_04165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CP97_04180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CP97_04185	COG0756	dUTP diphosphatase activity
CP97_04195	COG0180	Tryptophanyl-tRNA synthetase
CP97_04200	COG0728	peptidoglycan biosynthetic process
CP97_04205	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CP97_04210	COG4395	Tim44
CP97_04230	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CP97_04235	COG3634	alkyl hydroperoxide reductase activity
CP97_04240	COG0450	alkyl hydroperoxide reductase
CP97_04245	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CP97_04250	COG0632	four-way junction helicase activity
CP97_04260	COG2255	four-way junction helicase activity
CP97_04270	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CP97_04285	COG2989	Protein conserved in bacteria
CP97_04305	COG0123	including yeast histone deacetylase and acetoin utilization protein
CP97_04310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CP97_04320	COG0475	glutathione-regulated potassium exporter activity
CP97_04320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CP97_04355	COG0714	Associated with various cellular activities
CP97_04375	COG0077	Prephenate dehydratase
CP97_04380	COG3474	cytochrome
CP97_04385	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CP97_04410	COG2226	methyltransferase
CP97_04440	COG4771	TonB-dependent receptor
CP97_04455	COG0351	phosphomethylpyrimidine kinase
CP97_04455	COG0352	thiamine-phosphate diphosphorylase activity
CP97_04465	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CP97_04490	COG3920	Histidine kinase
CP97_04515	COG1987	bacterial-type flagellum assembly
CP97_04530	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CP97_04565	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CP97_04575	COG1677	Flagellar hook-basal body complex protein FliE
CP97_04585	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CP97_04610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CP97_04615	COG4786	Flagellar basal body rod
CP97_04615	COG1256	bacterial-type flagellum assembly
CP97_04625	COG1706	bacterial-type flagellum-dependent cell motility
CP97_04630	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CP97_04640	COG4787	bacterial-type flagellum-dependent cell motility
CP97_04650	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CP97_04665	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CP97_04705	COG0725	ABC transporter, periplasmic molybdate-binding protein
CP97_04710	COG4149	molybdate abc transporter
CP97_04715	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CP97_04720	COG1309	transcriptional regulator
CP97_04735	COG2814	Major facilitator Superfamily
CP97_04745	COG1215	transferase activity, transferring glycosyl groups
CP97_04755	COG4771	TonB-dependent receptor
CP97_04775	COG0436	Aminotransferase
CP97_04780	COG3243	poly(R)-hydroxyalkanoic acid synthase
CP97_04790	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CP97_04825	COG0784	Response regulator, receiver
CP97_04830	COG0534	Mate efflux family protein
CP97_04835	COG2080	2 iron, 2 sulfur cluster binding
CP97_04860	COG0321	lipoyl(octanoyl) transferase activity
CP97_04890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP97_04895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CP97_04910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP97_04925	COG0037	tRNA processing
CP97_04940	COG0800	Aldolase
CP97_04945	COG0837	glucose binding
CP97_04950	COG0129	dihydroxy-acid dehydratase activity
CP97_04955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CP97_04965	COG0432	Pfam Uncharacterised protein family UPF0047
CP97_04980	COG1404	Belongs to the peptidase S8 family
CP97_04990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP97_05005	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CP97_05010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CP97_05030	COG0741	lytic transglycosylase activity
CP97_05046	COG4974	Belongs to the 'phage' integrase family
CP97_05056	COG4974	Belongs to the 'phage' integrase family
CP97_05065	COG1475	DNA binding
CP97_05070	COG4227	nucleotidyltransferase activity
CP97_05100	COG0629	single-stranded DNA binding
CP97_05150	COG0629	single-stranded DNA binding
CP97_05210	COG3706	GGDEF domain
CP97_05380	COG1937	Protein conserved in bacteria
CP97_05385	COG2801	Transposase and inactivated derivatives
CP97_05385	COG3415	Transposase
CP97_05395	COG1304	FMN binding
CP97_05410	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP97_05440	COG0672	)-iron permease
CP97_05460	COG3293	Transposase
CP97_05465	COG3293	Transposase
CP97_05510	COG1620	l-lactate permease
CP97_05515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CP97_05525	COG0427	acetyl-CoA hydrolase
CP97_05530	COG2801	Transposase and inactivated derivatives
CP97_05550	COG2801	Transposase and inactivated derivatives
CP97_05550	COG3415	Transposase
CP97_05590	COG3920	Histidine kinase
CP97_05615	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CP97_05620	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CP97_05625	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CP97_05635	COG1960	acyl-CoA dehydrogenase activity
CP97_05640	COG2217	Heavy metal translocating P-type atpase
CP97_05660	COG0475	glutathione-regulated potassium exporter activity
CP97_05665	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP97_05665	COG0574	Belongs to the PEP-utilizing enzyme family
CP97_05670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CP97_05695	COG3459	Glycosyltransferase 36 associated
CP97_05725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP97_05730	COG0670	Belongs to the BI1 family
CP97_05740	COG0033	Phosphoglucomutase
CP97_05745	COG0129	dihydroxy-acid dehydratase activity
CP97_05755	COG3588	fructose-bisphosphate aldolase
CP97_05780	COG2132	Multicopper oxidase
CP97_05865	COG2217	Heavy metal translocating P-type atpase
CP97_05875	COG1937	Protein conserved in bacteria
CP97_05890	COG2801	Transposase and inactivated derivatives
CP97_05890	COG3415	Transposase
CP97_05915	COG0616	signal peptide processing
CP97_05920	COG0540	Belongs to the ATCase OTCase family
CP97_05925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CP97_05930	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_05955	COG2311	Membrane
CP97_05980	COG0746	molybdenum cofactor guanylyltransferase activity
CP97_05985	COG3383	formate dehydrogenase (NAD+) activity
CP97_05990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CP97_06015	COG1024	Enoyl-CoA hydratase
CP97_06035	COG2197	response regulator
CP97_06040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CP97_06045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP97_06045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP97_06080	COG0438	transferase activity, transferring glycosyl groups
CP97_06110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CP97_06125	COG0438	transferase activity, transferring glycosyl groups
CP97_06135	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CP97_06145	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CP97_06155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CP97_06160	COG0463	Glycosyl transferase, family 2
CP97_06180	COG5001	Diguanylate cyclase
CP97_06190	COG3437	response regulator, receiver
CP97_06215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CP97_06220	COG0737	Belongs to the 5'-nucleotidase family
CP97_06235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CP97_06260	COG5002	protein histidine kinase activity
CP97_06270	COG0745	RESPONSE REGULATOR receiver
CP97_06275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CP97_06285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CP97_06290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CP97_06295	COG0625	glutathione transferase activity
CP97_06300	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CP97_06315	COG1136	(ABC) transporter
CP97_06315	COG0577	efflux transmembrane transporter activity
CP97_06320	COG1136	(ABC) transporter
CP97_06320	COG0577	efflux transmembrane transporter activity
CP97_06345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP97_06350	COG2885	chlorophyll binding
CP97_06350	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CP97_06355	COG1960	acyl-CoA dehydrogenase activity
CP97_06380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CP97_06385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CP97_06390	COG0181	hydroxymethylbilane synthase activity
CP97_06405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CP97_06420	COG0556	nucleotide-excision repair
CP97_06440	COG0596	Alpha beta hydrolase
CP97_06440	COG2226	methyltransferase
CP97_06440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CP97_06445	COG2308	Evidence 4 Homologs of previously reported genes of
CP97_06475	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CP97_06480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CP97_06485	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CP97_06490	COG0656	L-ascorbic acid biosynthetic process
CP97_06495	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CP97_06505	COG0252	asparaginase activity
CP97_06520	COG0165	Argininosuccinate lyase
CP97_06530	COG0019	diaminopimelate decarboxylase activity
CP97_06535	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP97_06535	COG1648	precorrin-2 dehydrogenase activity
CP97_06540	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CP97_06550	COG0628	permease
CP97_06560	COG0736	holo-[acyl-carrier-protein] synthase activity
CP97_06565	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CP97_06570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CP97_06575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CP97_06580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CP97_06585	COG0109	protoheme IX farnesyltransferase activity
CP97_06595	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CP97_06640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CP97_06650	COG0314	molybdopterin synthase activity
CP97_06665	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CP97_06670	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CP97_06695	COG0418	dihydroorotase activity
CP97_06705	COG1012	belongs to the aldehyde dehydrogenase family
CP97_06710	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CP97_06740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CP97_06760	COG0789	Transcriptional regulator
CP97_06785	COG1194	a g-specific adenine glycosylase
CP97_06800	COG2816	NAD+ diphosphatase activity
CP97_06815	COG2239	Acts as a magnesium transporter
CP97_06825	COG0583	DNA-binding transcription factor activity
CP97_06830	COG1253	flavin adenine dinucleotide binding
CP97_06835	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CP97_06845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP97_06860	COG4957	zinc ion binding
CP97_06865	COG1247	-acetyltransferase
CP97_06880	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CP97_06885	COG0612	Peptidase, M16
CP97_06890	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CP97_06900	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CP97_06905	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CP97_06925	COG0625	glutathione transferase activity
CP97_06935	COG1054	Belongs to the UPF0176 family
CP97_06945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CP97_06970	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CP97_06985	COG1381	Involved in DNA repair and RecF pathway recombination
CP97_06990	COG0473	3-isopropylmalate dehydrogenase activity
CP97_07010	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CP97_07020	COG2967	ApaG domain
CP97_07025	COG0583	DNA-binding transcription factor activity
CP97_07085	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CP97_07090	COG0049	tRNA binding
CP97_07095	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CP97_07100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CP97_07110	COG0051	transcription antitermination factor activity, RNA binding
CP97_07115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CP97_07120	COG0088	Forms part of the polypeptide exit tunnel
CP97_07125	COG0089	rRNA binding
CP97_07130	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CP97_07135	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CP97_07140	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CP97_07145	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CP97_07150	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CP97_07155	COG0255	Belongs to the universal ribosomal protein uL29 family
CP97_07160	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CP97_07165	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CP97_07170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CP97_07175	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CP97_07180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CP97_07185	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CP97_07190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CP97_07195	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CP97_07200	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CP97_07205	COG1841	ribosomal large subunit assembly
CP97_07210	COG0200	Binds to the 23S rRNA
CP97_07215	COG0201	protein transport
CP97_07220	COG0563	adenylate kinase activity
CP97_07230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CP97_07235	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CP97_07240	COG0202	RNA polymerase activity
CP97_07245	COG0203	ribosomal protein L17
CP97_07250	COG1505	serine-type exopeptidase activity
CP97_07285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP97_07290	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP97_07295	COG0567	Dehydrogenase, E1 component
CP97_07300	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CP97_07310	COG0039	L-malate dehydrogenase activity
CP97_07325	COG4771	TonB-dependent receptor
CP97_07340	COG1120	ATPase activity
CP97_07345	COG0339	signal peptide processing
CP97_07360	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CP97_07390	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CP97_07405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CP97_07415	COG0137	argininosuccinate synthase activity
CP97_07425	COG0534	Mate efflux family protein
CP97_07430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP97_07440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CP97_07465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CP97_07485	COG2268	Band 7 protein
CP97_07500	COG0741	lytic transglycosylase activity
CP97_07505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP97_07515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CP97_07540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CP97_07545	COG2890	protein-(glutamine-N5) methyltransferase activity
CP97_07550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CP97_07565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CP97_07570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP97_07570	COG3153	acetyltransferase
CP97_07575	COG0538	isocitrate dehydrogenase activity
CP97_07595	COG2070	2-Nitropropane dioxygenase
CP97_07600	COG1960	acyl-CoA dehydrogenase activity
CP97_07605	COG1250	3-hydroxyacyl-CoA dehydrogenase
CP97_07605	COG1024	Enoyl-CoA hydratase
CP97_07610	COG0183	Belongs to the thiolase family
CP97_07615	COG0318	PFAM AMP-dependent synthetase and ligase
CP97_07660	COG0210	DNA helicase
CP97_07670	COG0742	ribosomal rna small subunit methyltransferase
CP97_07675	COG1187	pseudouridine synthase activity
CP97_07680	COG2223	nitrite transmembrane transporter activity
CP97_07685	COG0285	dihydrofolate synthase activity
CP97_07690	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CP97_07695	COG0159	tryptophan synthase activity
CP97_07700	COG0133	tryptophan synthase activity
CP97_07705	COG0135	phosphoribosylanthranilate isomerase activity
CP97_07715	COG0284	orotidine-5'-phosphate decarboxylase activity
CP97_07725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CP97_07730	COG2003	Belongs to the UPF0758 family
CP97_07755	COG0356	it plays a direct role in the translocation of protons across the membrane
CP97_07760	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP97_07765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CP97_07770	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CP97_07775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP97_07780	COG0539	negative regulation of cytoplasmic translation
CP97_07785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CP97_07795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CP97_07810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CP97_07815	COG0228	four-way junction DNA binding
CP97_07820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CP97_07830	COG0336	Belongs to the RNA methyltransferase TrmD family
CP97_07835	COG0335	large ribosomal subunit rRNA binding
CP97_07840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CP97_07860	COG0659	secondary active sulfate transmembrane transporter activity
CP97_07865	COG0359	binds to the 23S rRNA
CP97_07870	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CP97_07875	COG0360	Binds together with S18 to 16S ribosomal RNA
CP97_07880	COG2354	Protein conserved in bacteria
CP97_07890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CP97_07900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CP97_07920	COG0493	'glutamate synthase
CP97_07925	COG3300	MHYT domain
CP97_07925	COG5001	Diguanylate cyclase
CP97_07930	COG0481	GTPase activity
CP97_07970	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP97_07985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CP97_07990	COG4221	oxidoreductase activity
CP97_08000	COG2264	protein methyltransferase activity
CP97_08005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP97_08010	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_08015	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CP97_08035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CP97_08060	COG1595	DNA-templated transcription, initiation
CP97_08075	COG2321	neutral zinc metallopeptidase
CP97_08080	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_08105	COG1051	belongs to the nudix hydrolase family
CP97_08110	COG0674	pyruvate-flavodoxin oxidoreductase activity
CP97_08110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CP97_08115	COG1013	pyruvate-flavodoxin oxidoreductase activity
CP97_08125	COG0415	Belongs to the DNA photolyase family
CP97_08130	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP97_08145	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CP97_08160	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_08165	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CP97_08180	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CP97_08210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CP97_08230	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CP97_08235	COG0126	phosphoglycerate kinase activity
CP97_08255	COG3588	fructose-bisphosphate aldolase
CP97_08260	COG0352	thiamine-phosphate diphosphorylase activity
CP97_08270	COG1376	ErfK ybiS ycfS ynhG family protein
CP97_08285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CP97_08290	COG0483	inositol monophosphate 1-phosphatase activity
CP97_08300	COG0471	metal ion transport
CP97_08300	COG3273	potassium ion transport
CP97_08310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CP97_08320	COG2204	response regulator
CP97_08325	COG0385	Bile acid
CP97_08335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CP97_08340	COG0733	neurotransmitter:sodium symporter activity
CP97_08360	COG1525	nuclease
CP97_08370	COG1609	Transcriptional regulator
CP97_08380	COG2205	protein histidine kinase activity
CP97_08385	COG1522	sequence-specific DNA binding
CP97_08395	COG0439	Biotin carboxylase
CP97_08400	COG0511	ligase activity, forming carbon-carbon bonds
CP97_08405	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CP97_08420	COG1862	Preprotein translocase
CP97_08425	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP97_08430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CP97_08435	COG0438	transferase activity, transferring glycosyl groups
CP97_08455	COG0488	(ABC) transporter
CP97_08485	COG1605	Chorismate mutase
CP97_08485	COG0287	Prephenate dehydrogenase
CP97_08490	COG0142	geranyltranstransferase activity
CP97_08495	COG1643	Atp-dependent helicase
CP97_08505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CP97_08510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CP97_08520	COG0776	regulation of translation
CP97_08525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP97_08555	COG4206	TonB-dependent receptor
CP97_08580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CP97_08585	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CP97_08595	COG3800	Transcriptional regulator
CP97_08595	COG1396	sequence-specific DNA binding
CP97_08600	COG0688	phosphatidylethanolamine metabolic process
CP97_08610	COG0052	Belongs to the universal ribosomal protein uS2 family
CP97_08615	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CP97_08620	COG0528	UMP kinase activity
CP97_08625	COG0233	cytoplasmic translational termination
CP97_08630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CP97_08640	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CP97_08645	COG0750	zinc metalloprotease
CP97_08650	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CP97_08660	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CP97_08665	COG0254	rRNA binding
CP97_08695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CP97_08700	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CP97_08705	COG1138	Cytochrome C-type biogenesis protein
CP97_08725	COG3158	transport of potassium into the cell
CP97_08730	COG2917	probably involved in intracellular septation
CP97_08735	COG0552	protein localization to endoplasmic reticulum
CP97_08740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CP97_08745	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CP97_08760	COG0028	Belongs to the TPP enzyme family
CP97_08770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CP97_08775	COG0583	DNA-binding transcription factor activity
CP97_08780	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CP97_08785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CP97_08795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CP97_08800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CP97_08805	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CP97_08825	COG1024	Enoyl-CoA hydratase
CP97_08845	COG1960	acyl-CoA dehydrogenase activity
CP97_08850	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_08860	COG0156	8-amino-7-oxononanoate synthase activity
CP97_08870	COG4106	trans-aconitate 2-methyltransferase activity
CP97_08885	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CP97_08890	COG1877	trehalose-phosphatase activity
CP97_08895	COG3387	PFAM Glycoside hydrolase 15-related
CP97_08900	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CP97_08915	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CP97_08935	COG1704	LemA family
CP97_08945	COG3300	MHYT domain
CP97_08945	COG5001	Diguanylate cyclase
CP97_08950	COG0156	8-amino-7-oxononanoate synthase activity
CP97_08955	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CP97_08960	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CP97_08965	COG0758	DNA mediated transformation
CP97_08975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CP97_08975	COG1754	DNA topoisomerase type I activity
CP97_08985	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CP97_08990	COG0571	ribonuclease III activity
CP97_09000	COG0166	Belongs to the GPI family
CP97_09005	COG0513	Belongs to the DEAD box helicase family
CP97_09035	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CP97_09040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CP97_09055	COG4974	Belongs to the 'phage' integrase family
CP97_09060	COG0825	malonyl-CoA metabolic process
CP97_09065	COG4783	chaperone-mediated protein folding
CP97_09075	COG0494	nUDIX hydrolase
CP97_09090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CP97_09095	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CP97_09110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CP97_09115	COG0302	gtp cyclohydrolase
CP97_09125	COG0678	peroxiredoxin activity
CP97_09125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CP97_09130	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CP97_09135	COG2205	protein histidine kinase activity
CP97_09140	COG0802	atpase or kinase
CP97_09145	COG3178	'Phosphotransferase
CP97_09150	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CP97_09155	COG2887	Belongs to the helicase family. UvrD subfamily
CP97_09160	COG1074	ATP-dependent DNA helicase activity
CP97_09170	COG0483	inositol monophosphate 1-phosphatase activity
CP97_09175	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CP97_09185	COG0653	protein targeting
CP97_09200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CP97_09210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CP97_09225	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CP97_09240	COG1136	(ABC) transporter
CP97_09275	COG0521	Mo-molybdopterin cofactor biosynthetic process
CP97_09295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CP97_09305	COG0129	dihydroxy-acid dehydratase activity
CP97_09315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CP97_09315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CP97_09320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CP97_09345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CP97_09375	COG3409	Peptidoglycan-binding domain 1 protein
CP97_09375	COG3267	Type II secretory pathway component ExeA
CP97_09400	COG0367	asparagine synthase
CP97_09405	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CP97_09420	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP97_09430	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CP97_09435	COG1530	ribonuclease E activity
CP97_09445	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CP97_09465	COG0004	ammonium transporteR
CP97_09480	COG0183	Belongs to the thiolase family
CP97_09490	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP97_09495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP97_09500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP97_09505	COG0649	NAD binding
CP97_09510	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CP97_09515	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CP97_09520	COG1034	ATP synthesis coupled electron transport
CP97_09525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CP97_09530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CP97_09540	COG0713	ATP synthesis coupled electron transport
CP97_09555	COG1007	ATP synthesis coupled electron transport
CP97_09565	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CP97_09600	COG2205	protein histidine kinase activity
CP97_09605	COG0372	Belongs to the citrate synthase family
CP97_09610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CP97_09615	COG0658	competence protein
CP97_09615	COG2333	competence protein COMEC
CP97_09620	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CP97_09625	COG0303	'Molybdopterin
CP97_09630	COG0315	cyclic pyranopterin monophosphate synthase activity
CP97_09640	COG0134	indole-3-glycerol-phosphate synthase activity
CP97_09645	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CP97_09660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CP97_09665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CP97_09670	COG0149	triose-phosphate isomerase activity
CP97_09680	COG0504	CTP synthase activity
CP97_09685	COG0071	Belongs to the small heat shock protein (HSP20) family
CP97_09690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CP97_09690	COG0678	peroxiredoxin activity
CP97_09695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CP97_09720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CP97_09725	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP97_09725	COG0022	dehydrogenase e1 component
CP97_09755	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CP97_09765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP97_09780	COG0012	GTP binding
CP97_09800	COG0193	aminoacyl-tRNA hydrolase activity
CP97_09805	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CP97_09835	COG0752	glycyl-tRNA synthetase alpha subunit
CP97_09840	COG0751	glycine-tRNA ligase activity
CP97_09845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP97_09845	COG0574	Belongs to the PEP-utilizing enzyme family
CP97_09860	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CP97_09880	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CP97_09890	COG3876	Protein conserved in bacteria
CP97_09910	COG0187	DNA topoisomerase II activity
CP97_09915	COG3107	peptidoglycan biosynthetic process
CP97_09920	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CP97_09925	COG0792	nuclease activity
CP97_09930	COG0189	ligase activity
CP97_09935	COG0586	Pfam SNARE associated Golgi protein
CP97_09940	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CP97_09945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CP97_09955	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CP97_09960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CP97_09965	COG1420	regulation of RNA biosynthetic process
CP97_09970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CP97_09980	COG0456	acetyltransferase
CP97_09980	COG0454	-acetyltransferase
CP97_09995	COG0443	Heat shock 70 kDa protein
CP97_10000	COG0484	heat shock protein binding
CP97_10005	COG1752	Esterase of the alpha-beta hydrolase superfamily
CP97_10025	COG0477	Major facilitator Superfamily
CP97_10030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CP97_10040	COG0442	prolyl-tRNA aminoacylation
CP97_10050	COG2234	aminopeptidase activity
CP97_10055	COG0557	exoribonuclease II activity
CP97_10070	COG0508	dehydrogenase complex catalyzes the overall conversion of
CP97_10075	COG1607	acyl-coa hydrolase
CP97_10080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CP97_10095	COG2951	lytic endotransglycosylase activity
CP97_10105	COG1686	Belongs to the peptidase S11 family
CP97_10110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CP97_10115	COG0470	DNA polymerase III
CP97_10120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CP97_10125	COG0084	hydrolase, TatD family'
CP97_10135	COG3956	TIGRFAM MazG family protein
CP97_10140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CP97_10150	COG2204	response regulator
CP97_10155	COG5000	phosphorelay sensor kinase activity
CP97_10160	COG2204	response regulator
CP97_10165	COG3852	Histidine kinase
CP97_10185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CP97_10185	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CP97_10190	COG1546	Belongs to the CinA family
CP97_10190	COG1058	Belongs to the CinA family
CP97_10200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CP97_10205	COG0288	reversible hydration of carbon dioxide
CP97_10230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CP97_10255	COG0772	Belongs to the SEDS family
CP97_10265	COG1396	sequence-specific DNA binding
CP97_10265	COG3800	Transcriptional regulator
CP97_10285	COG1366	Belongs to the anti-sigma-factor antagonist family
CP97_10290	COG1366	Belongs to the anti-sigma-factor antagonist family
CP97_10300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CP97_10310	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CP97_10320	COG0148	phosphopyruvate hydratase activity
CP97_10370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CP97_10385	COG0505	Belongs to the CarA family
CP97_10400	COG0358	DNA primase activity
CP97_10405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP97_10425	COG0698	ribose 5-phosphate isomerase
CP97_10430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CP97_10440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CP97_10450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CP97_10460	COG0343	queuine tRNA-ribosyltransferase activity
CP97_10470	COG0842	Transport permease protein
CP97_10475	COG1131	(ABC) transporter
CP97_10480	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CP97_10490	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CP97_10495	COG0142	geranyltranstransferase activity
CP97_10500	COG1722	exodeoxyribonuclease VII activity
CP97_10505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP97_10525	COG0560	Phosphoserine phosphatase
CP97_10530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CP97_10535	COG0028	Belongs to the TPP enzyme family
CP97_10540	COG0440	acetolactate synthase activity
CP97_10550	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CP97_10555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CP97_10560	COG0784	Response regulator, receiver
CP97_10560	COG2205	protein histidine kinase activity
CP97_10575	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CP97_10590	COG5002	protein histidine kinase activity
CP97_10595	COG3746	phosphate-selective porin O and P
CP97_10605	COG0573	inorganic phosphate transmembrane transporter activity
CP97_10615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CP97_10620	COG0704	Plays a role in the regulation of phosphate uptake
CP97_10625	COG0745	RESPONSE REGULATOR receiver
CP97_10635	COG0587	DNA-directed DNA polymerase activity
CP97_10650	COG1253	flavin adenine dinucleotide binding
CP97_10665	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CP97_10670	COG2323	membrane
CP97_10705	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CP97_10710	COG0668	transmembrane transport
CP97_10720	COG1199	ATP-dependent helicase activity
CP97_10735	COG0776	regulation of translation
CP97_10740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CP97_10745	COG0416	fatty acid biosynthetic process
CP97_10760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP97_10780	COG0215	cysteine-tRNA ligase activity
CP97_10820	COG0646	methionine synthase
CP97_10820	COG1410	methionine synthase
CP97_10830	COG2169	Transcriptional regulator
CP97_10830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CP97_10840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CP97_10845	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CP97_10850	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CP97_10860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CP97_10865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CP97_10950	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CP97_10960	COG1404	Belongs to the peptidase S8 family
CP97_10985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CP97_10990	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CP97_10995	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CP97_11000	COG2133	pyrroloquinoline quinone binding
CP97_11015	COG0494	nUDIX hydrolase
CP97_11020	COG0617	tRNA 3'-terminal CCA addition
CP97_11030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CP97_11035	COG0693	protein deglycase activity
CP97_11050	COG0596	Alpha beta hydrolase
CP97_11060	COG1104	cysteine desulfurase activity
CP97_11065	COG1104	cysteine desulfurase activity
CP97_11095	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CP97_11100	COG0745	RESPONSE REGULATOR receiver
CP97_11105	COG2205	protein histidine kinase activity
CP97_11115	COG1660	Displays ATPase and GTPase activities
CP97_11120	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CP97_11120	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CP97_11130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CP97_11140	COG1322	Protein conserved in bacteria
CP97_11160	COG0242	peptide deformylase activity
CP97_11165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CP97_11170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CP97_11175	COG0101	tRNA pseudouridine synthase activity
CP97_11235	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CP97_11240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CP97_11245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CP97_11250	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CP97_11255	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CP97_11270	COG1946	Acyl-CoA thioesterase
CP97_11285	COG0322	excinuclease ABC activity
CP97_11290	COG0531	amino acid
CP97_11295	COG2081	HI0933 family
CP97_11305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CP97_11310	COG0424	maF-like protein
CP97_11335	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CP97_11350	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CP97_11355	COG0047	phosphoribosylformylglycinamidine synthase activity
CP97_11360	COG5001	Diguanylate cyclase
CP97_11365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CP97_11375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CP97_11380	COG0546	phosphoglycolate phosphatase activity
CP97_11390	COG1045	serine acetyltransferase
CP97_11405	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CP97_11410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CP97_11420	COG0105	UTP biosynthetic process
CP97_11435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CP97_11440	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CP97_11445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CP97_11450	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CP97_11455	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CP97_11470	COG3724	N-succinylarginine dihydrolase activity
CP97_11480	COG1970	mechanosensitive ion channel activity
CP97_11485	COG1970	mechanosensitive ion channel activity
CP97_11510	COG0572	uridine kinase
CP97_11515	COG4566	intracellular signal transduction
CP97_11520	COG4946	Tricorn protease homolog
CP97_11520	COG0793	Belongs to the peptidase S41A family
CP97_11530	COG2030	dehydratase
CP97_11620	COG0842	Transport permease protein
CP97_11645	COG1185	polyribonucleotide nucleotidyltransferase activity
CP97_11650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CP97_11655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CP97_11660	COG1994	Peptidase M50
CP97_11665	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CP97_11680	COG1435	thymidine kinase activity
CP97_11685	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CP97_11695	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CP97_11710	COG0779	Required for maturation of 30S ribosomal subunits
CP97_11720	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CP97_11730	COG1842	Phage shock protein A
CP97_11775	COG2166	iron-sulfur cluster assembly
CP97_11780	COG0401	homolog of Blt101
CP97_11805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CP97_11820	COG0066	3-isopropylmalate dehydratase activity
CP97_11835	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CP97_11850	COG1012	belongs to the aldehyde dehydrogenase family
CP97_11860	COG0457	Tetratricopeptide repeat
CP97_11870	COG4206	TonB-dependent receptor
CP97_11885	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CP97_11900	COG4181	ATPase activity
CP97_11910	COG3152	Membrane
CP97_11915	COG1714	RDD family
CP97_11920	COG4771	TonB-dependent receptor
CP97_11925	COG1217	gtp-binding protein TYPA
CP97_11940	COG1695	Transcriptional regulator
CP97_11945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CP97_11960	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CP97_11965	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CP97_11975	COG2897	thiosulfate sulfurtransferase activity
CP97_11980	COG0626	cystathionine gamma-synthase activity
CP97_11985	COG0668	transmembrane transport
CP97_11990	COG1648	precorrin-2 dehydrogenase activity
CP97_11990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP97_12000	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP97_12010	COG0175	sulfate reduction
CP97_12030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CP97_12035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CP97_12050	COG0670	Belongs to the BI1 family
CP97_12055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CP97_12075	COG0849	cell division
CP97_12080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CP97_12085	COG1181	Belongs to the D-alanine--D-alanine ligase family
CP97_12090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CP97_12095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CP97_12100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CP97_12110	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CP97_12115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CP97_12120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CP97_12125	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CP97_12140	COG0275	rRNA processing
CP97_12160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CP97_12180	COG2154	pterin-4-alpha-carbinolamine dehydratase
CP97_12185	COG4133	protoheme IX ABC transporter activity
CP97_12190	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CP97_12200	COG0024	Methionine aminopeptidase
CP97_12210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CP97_12230	COG0174	glutamine synthetase
CP97_12255	COG0729	surface antigen
CP97_12260	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CP97_12265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CP97_12270	COG2084	Dehydrogenase
CP97_12275	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CP97_12280	COG0805	protein transport
CP97_12285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP97_12295	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CP97_12300	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CP97_12315	COG0018	arginyl-trna synthetase
CP97_12325	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CP97_12330	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CP97_12335	COG0328	RNA-DNA hybrid ribonuclease activity
CP97_12360	COG4964	Belongs to the GSP D family
CP97_12390	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CP97_12410	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CP97_12420	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP97_12425	COG0154	amidase activity
CP97_12430	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CP97_12440	COG0545	Peptidyl-prolyl cis-trans isomerase
CP97_12445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CP97_12450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CP97_12455	COG0564	pseudouridine synthase activity
CP97_12485	COG1127	ABC transporter
CP97_12495	COG0525	valine-tRNA ligase activity
CP97_12515	COG0730	response to heat
CP97_12530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CP97_12550	COG0544	peptidyl-prolyl cis-trans isomerase activity
CP97_12565	COG0740	serine-type endopeptidase activity
CP97_12570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CP97_12595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CP97_12600	COG0564	pseudouridine synthase activity
CP97_12615	COG3023	N-Acetylmuramoyl-L-alanine amidase
CP97_12620	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CP97_12635	COG1160	GTP binding
CP97_12660	COG2030	dehydratase
CP97_12665	COG0045	succinate-CoA ligase (ADP-forming) activity
CP97_12665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CP97_12665	COG1042	CoA-binding domain protein
CP97_12670	COG0183	Belongs to the thiolase family
CP97_12695	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_12700	COG1960	acyl-CoA dehydrogenase activity
CP97_12705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP97_12710	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CP97_12745	COG0408	coproporphyrinogen oxidase activity
CP97_12755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CP97_12760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CP97_12770	COG0471	metal ion transport
CP97_12790	COG0484	heat shock protein binding
CP97_12795	COG2885	chlorophyll binding
CP97_12800	COG0823	Involved in the tonB-independent uptake of proteins
CP97_12820	COG0824	Thioesterase
CP97_12830	COG0140	phosphoribosyl-ATP diphosphatase activity
CP97_12840	COG0107	imidazoleglycerol-phosphate synthase activity
CP97_12845	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CP97_12850	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CP97_12855	COG0131	Imidazoleglycerol-phosphate dehydratase
CP97_12870	COG0194	GDP metabolic process
CP97_12875	COG2171	N-acyltransferase activity
CP97_12945	COG1278	Cold shock
CP97_12950	COG1671	Belongs to the UPF0178 family
CP97_12980	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
CP97_12990	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CP97_13005	COG1506	peptidase
CP97_13005	COG4946	Tricorn protease homolog
CP97_13005	COG0823	Involved in the tonB-independent uptake of proteins
CP97_13040	COG4770	biotin carboxylase activity
CP97_13060	COG0494	nUDIX hydrolase
CP97_13070	COG0783	Belongs to the Dps family
CP97_13085	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CP97_13090	COG0753	catalase activity
CP97_13170	COG0582	viral genome integration into host DNA
CP97_13195	COG1960	acyl-CoA dehydrogenase activity
CP97_13200	COG1024	Enoyl-CoA hydratase
CP97_13205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CP97_13225	COG0488	(ABC) transporter
CP97_13250	COG2010	Cytochrome c
CP97_13285	COG0443	Heat shock 70 kDa protein
CP97_13335	COG5265	(ABC) transporter
CP97_13340	COG0659	secondary active sulfate transmembrane transporter activity
CP97_13345	COG2095	MarC family integral membrane protein
CP97_13350	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CP97_13360	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CP97_13380	COG0629	single-stranded DNA binding
CP97_13385	COG1918	ferrous iron import across plasma membrane
CP97_13385	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CP97_13405	COG1999	signal sequence binding
CP97_13410	COG2983	Belongs to the UPF0260 family
CP97_13425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CP97_13425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CP97_13445	COG1448	Aminotransferase
CP97_13460	COG0582	viral genome integration into host DNA
CP97_13485	COG0668	transmembrane transport
CP97_13520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CP97_13525	COG3550	peptidyl-serine autophosphorylation
CP97_13530	COG1396	sequence-specific DNA binding
CP97_13540	COG3047	cAMP biosynthetic process
CP97_13545	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CP97_13560	COG4771	TonB-dependent receptor
CP97_13565	COG0318	PFAM AMP-dependent synthetase and ligase
CP97_13585	COG4638	Rieske (2fe-2S)
CP97_13590	COG1309	transcriptional regulator
CP97_13600	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_13605	COG0671	phosphoesterase, PA-phosphatase related
CP97_13610	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CP97_13615	COG0509	glycine decarboxylation via glycine cleavage system
CP97_13620	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP97_13625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CP97_13650	COG1196	nuclear chromosome segregation
CP97_13650	COG0739	heme binding
CP97_13650	COG0741	lytic transglycosylase activity
CP97_13665	COG3451	type IV secretory pathway VirB4
CP97_13685	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
CP97_13690	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CP97_13695	COG0248	Ppx GppA phosphatase
CP97_13730	COG1546	Belongs to the CinA family
CP97_13730	COG1058	Belongs to the CinA family
CP97_13735	COG0081	regulation of translation
CP97_13740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CP97_13760	COG1115	amino acid carrier protein
CP97_13775	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CP97_13800	COG0318	PFAM AMP-dependent synthetase and ligase
CP97_13835	COG0662	Cupin 2, conserved barrel domain protein
CP97_13835	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CP97_13860	COG0450	alkyl hydroperoxide reductase
CP97_13885	COG0446	pyridine nucleotide-disulphide oxidoreductase
CP97_13900	COG1294	oxidase, subunit
CP97_13905	COG1024	Enoyl-CoA hydratase
CP97_13920	COG4770	biotin carboxylase activity
CP97_13925	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP97_13925	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CP97_13930	COG0346	lactoylglutathione lyase activity
CP97_13940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CP97_13955	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CP97_13960	COG0243	molybdopterin cofactor binding
CP97_13965	COG2146	nitrite reductase [NAD(P)H] activity
CP97_13970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CP97_13980	COG1116	anion transmembrane transporter activity
CP97_13980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CP97_13985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CP97_13990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CP97_13990	COG1116	anion transmembrane transporter activity
CP97_13995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CP97_14000	COG0745	RESPONSE REGULATOR receiver
CP97_14010	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CP97_14020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CP97_14030	COG0473	3-isopropylmalate dehydrogenase activity
CP97_14040	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CP97_14045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CP97_14060	COG2814	Major facilitator Superfamily
CP97_14070	COG3971	2-oxopent-4-enoate hydratase activity
CP97_14085	COG2271	Major facilitator Superfamily
CP97_14110	COG1012	belongs to the aldehyde dehydrogenase family
CP97_14135	COG4771	TonB-dependent receptor
CP97_14150	COG4638	Rieske (2fe-2S)
CP97_14165	COG0346	lactoylglutathione lyase activity
CP97_14170	COG4638	Rieske (2fe-2S)
CP97_14185	COG4638	Rieske (2fe-2S)
CP97_14190	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CP97_14220	COG3971	2-oxopent-4-enoate hydratase activity
CP97_14240	COG1942	4-Oxalocrotonate Tautomerase
CP97_14245	COG1012	belongs to the aldehyde dehydrogenase family
CP97_14250	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_14295	COG4771	TonB-dependent receptor
CP97_14310	COG1566	PFAM secretion protein HlyD family protein
CP97_14330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CP97_14335	COG0730	response to heat
CP97_14365	COG0842	Transport permease protein
CP97_14370	COG0842	Transport permease protein
CP97_14370	COG1129	ABC transporter
CP97_14375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CP97_14385	COG0628	permease
CP97_14390	COG1063	alcohol dehydrogenase
CP97_14400	COG0574	Belongs to the PEP-utilizing enzyme family
CP97_14400	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CP97_14405	COG3459	Glycosyltransferase 36 associated
CP97_14455	COG1137	ATPase activity
CP97_14470	COG4191	Histidine kinase
CP97_14475	COG4566	intracellular signal transduction
CP97_14495	COG2217	Heavy metal translocating P-type atpase
CP97_14505	COG0668	transmembrane transport
CP97_14510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CP97_14515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CP97_14520	COG1127	ABC transporter
CP97_14535	COG1309	transcriptional regulator
CP97_14545	COG0798	PFAM Bile acid sodium symporter
CP97_14580	COG4638	Rieske (2fe-2S)
CP97_14585	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CP97_14595	COG0318	PFAM AMP-dependent synthetase and ligase
CP97_14605	COG1024	Enoyl-CoA hydratase
CP97_14620	COG4771	TonB-dependent receptor
CP97_14626	COG1309	transcriptional regulator
CP97_14628	COG0318	PFAM AMP-dependent synthetase and ligase
CP97_14648	COG1597	lipid kinase activity
CP97_14656	COG0457	Tetratricopeptide repeat
CP97_14677	COG0589	response to stress
CP97_14683	COG1620	l-lactate permease
CP97_14701	COG2205	protein histidine kinase activity
CP97_14701	COG2202	Pas domain
CP97_14706	COG4566	intracellular signal transduction
CP97_14709	COG2197	response regulator
CP97_14745	COG3300	MHYT domain
CP97_14745	COG5001	Diguanylate cyclase
CP97_14771	COG2205	protein histidine kinase activity
CP97_14785	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CP97_14786	COG2234	aminopeptidase activity
CP97_14789	COG0612	Peptidase, M16
CP97_14799	COG0484	heat shock protein binding
CP97_14806	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CP97_14807	COG3422	double-strand break repair
CP97_14824	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CP97_14837	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CP97_14838	COG2072	flavoprotein involved in K transport
CP97_14849	COG1414	Transcriptional regulator
CP97_14862	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CP97_14874	COG1252	NADH dehydrogenase
CP97_14875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CP97_14880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CP97_14881	COG0668	transmembrane transport
CP97_14884	COG2205	protein histidine kinase activity
CP97_14888	COG1846	Transcriptional regulator
CP97_14889	COG1764	response to oxidative stress
CP97_14891	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CP97_14904	COG0629	single-stranded DNA binding
CP97_14911	COG0530	calcium, potassium:sodium antiporter activity
CP97_14914	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CP97_14918	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CP97_14923	COG0114	fumarate hydratase activity
CP97_14925	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CP97_14927	COG1285	pathogenesis
CP97_14929	COG1028	Short-chain dehydrogenase reductase Sdr
CP97_14934	COG0517	IMP dehydrogenase activity
CP97_14944	COG0629	single-stranded DNA binding
CP97_14949	COG0739	heme binding
CP97_14949	COG0741	lytic transglycosylase activity
CP97_14949	COG1196	nuclear chromosome segregation
CP97_14982	COG0697	spore germination
CP97_14997	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CP97_14999	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CP97_15015	COG2132	Multicopper oxidase
CP97_15019	COG4993	Dehydrogenase
CP97_15021	COG2132	Multicopper oxidase
CP97_15024	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CP97_15025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CP97_15028	COG0517	IMP dehydrogenase activity
CP97_15028	COG0516	GMP reductase activity
CP97_15033	COG0789	Transcriptional regulator
CP97_15034	COG1742	UPF0060 membrane protein
CP97_15035	COG4772	TonB-dependent receptor
CP97_15049	COG0672	)-iron permease
CP97_15050	COG2132	Multicopper oxidase
CP97_15052	COG1012	belongs to the aldehyde dehydrogenase family
CP97_15053	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CP97_15054	COG0450	alkyl hydroperoxide reductase
CP97_15056	COG2124	cytochrome p450
CP97_15095	COG1475	DNA binding