locus-tag	class	description
BMF35_a0003	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BMF35_a0004	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BMF35_a0007	COG0105	UTP biosynthetic process
BMF35_a0010	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BMF35_a0012	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BMF35_a0013	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BMF35_a0014	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BMF35_a0018	COG3724	N-succinylarginine dihydrolase activity
BMF35_a0020	COG1970	mechanosensitive ion channel activity
BMF35_a0025	COG0572	uridine kinase
BMF35_a0026	COG4566	intracellular signal transduction
BMF35_a0029	COG1082	Xylose isomerase domain protein TIM barrel
BMF35_a0030	COG0366	Alpha amylase catalytic
BMF35_a0040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BMF35_a0043	COG0737	Belongs to the 5'-nucleotidase family
BMF35_a0044	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BMF35_a0047	COG3268	Saccharopine dehydrogenase
BMF35_a0048	COG2186	Transcriptional regulator
BMF35_a0049	COG4948	Mandelate Racemase Muconate Lactonizing
BMF35_a0050	COG2211	Major facilitator Superfamily
BMF35_a0051	COG3250	beta-galactosidase activity
BMF35_a0052	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BMF35_a0053	COG4948	Mandelate Racemase Muconate Lactonizing
BMF35_a0055	COG4948	Mandelate Racemase Muconate Lactonizing
BMF35_a0060	COG3250	beta-galactosidase activity
BMF35_a0062	COG2721	sulfolactate sulfo-lyase activity
BMF35_a0063	COG0246	Mannitol dehydrogenase
BMF35_a0066	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BMF35_a0067	COG1904	glucuronate isomerase
BMF35_a0068	COG2186	Transcriptional regulator
BMF35_a0069	COG0840	transmembrane signaling receptor activity
BMF35_a0072	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BMF35_a0078	COG0842	Transport permease protein
BMF35_a0082	COG0189	ligase activity
BMF35_a0083	COG0189	ligase activity
BMF35_a0083	COG4067	protein conserved in archaea
BMF35_a0084	COG1185	polyribonucleotide nucleotidyltransferase activity
BMF35_a0085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BMF35_a0086	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BMF35_a0087	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BMF35_a0088	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BMF35_a0090	COG1435	thymidine kinase activity
BMF35_a0091	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BMF35_a0093	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BMF35_a0096	COG0779	Required for maturation of 30S ribosomal subunits
BMF35_a0098	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BMF35_a0100	COG1842	Phage shock protein A
BMF35_a0109	COG2166	iron-sulfur cluster assembly
BMF35_a0110	COG2832	Protein of unknown function (DUF454)
BMF35_a0117	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BMF35_a0119	COG0066	3-isopropylmalate dehydratase activity
BMF35_a0122	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BMF35_a0129	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BMF35_a0131	COG4181	ATPase activity
BMF35_a0133	COG1714	RDD family
BMF35_a0135	COG3152	Membrane
BMF35_a0136	COG4771	TonB-dependent receptor
BMF35_a0137	COG1217	gtp-binding protein TYPA
BMF35_a0140	COG0640	Transcriptional regulator
BMF35_a0141	COG0297	glycogen (starch) synthase activity
BMF35_a0144	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BMF35_a0148	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BMF35_a0150	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BMF35_a0151	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BMF35_a0152	COG2897	thiosulfate sulfurtransferase activity
BMF35_a0153	COG0626	cystathionine gamma-synthase activity
BMF35_a0154	COG0668	transmembrane transport
BMF35_a0155	COG1648	precorrin-2 dehydrogenase activity
BMF35_a0155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BMF35_a0157	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BMF35_a0159	COG0175	sulfate reduction
BMF35_a0164	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BMF35_a0165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BMF35_a0168	COG0670	Belongs to the BI1 family
BMF35_a0169	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BMF35_a0173	COG0849	cell division
BMF35_a0174	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BMF35_a0175	COG1181	Belongs to the D-alanine--D-alanine ligase family
BMF35_a0176	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BMF35_a0177	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BMF35_a0178	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BMF35_a0180	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BMF35_a0181	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BMF35_a0182	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BMF35_a0183	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BMF35_a0186	COG0275	rRNA processing
BMF35_a0187	COG2001	Belongs to the MraZ family
BMF35_a0195	COG4221	oxidoreductase activity
BMF35_a0196	COG2154	pterin-4-alpha-carbinolamine dehydratase
BMF35_a0197	COG4133	protoheme IX ABC transporter activity
BMF35_a0198	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BMF35_a0200	COG0024	Methionine aminopeptidase
BMF35_a0202	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BMF35_a0206	COG0174	glutamine synthetase
BMF35_a0211	COG1476	TRANSCRIPTIONal
BMF35_a0216	COG0729	surface antigen
BMF35_a0217	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BMF35_a0218	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BMF35_a0219	COG2084	Dehydrogenase
BMF35_a0220	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BMF35_a0222	COG0805	protein transport
BMF35_a0223	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BMF35_a0224	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BMF35_a0225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BMF35_a0226	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BMF35_a0229	COG0018	arginyl-trna synthetase
BMF35_a0231	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BMF35_a0232	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BMF35_a0233	COG0328	RNA-DNA hybrid ribonuclease activity
BMF35_a0234	COG3422	double-strand break repair
BMF35_a0240	COG4964	Belongs to the GSP D family
BMF35_a0246	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BMF35_a0248	COG4771	TonB-dependent receptor
BMF35_a0252	COG1131	(ABC) transporter
BMF35_a0258	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BMF35_a0261	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BMF35_a0263	COG0154	amidase activity
BMF35_a0264	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BMF35_a0266	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BMF35_a0267	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BMF35_a0269	COG0546	phosphoglycolate phosphatase activity
BMF35_a0275	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BMF35_a0276	COG0525	valine-tRNA ligase activity
BMF35_a0280	COG0730	response to heat
BMF35_a0283	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BMF35_a0286	COG0544	peptidyl-prolyl cis-trans isomerase activity
BMF35_a0288	COG0154	amidase activity
BMF35_a0290	COG0840	transmembrane signaling receptor activity
BMF35_a0291	COG0740	serine-type endopeptidase activity
BMF35_a0292	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BMF35_a0297	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BMF35_a0300	COG1230	cation diffusion facilitator family transporter
BMF35_a0303	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BMF35_a0304	COG0564	pseudouridine synthase activity
BMF35_a0307	COG3023	N-Acetylmuramoyl-L-alanine amidase
BMF35_a0308	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BMF35_a0312	COG1160	GTP binding
BMF35_a0315	COG2311	Membrane
BMF35_a0320	COG1028	Short-chain dehydrogenase reductase Sdr
BMF35_a0321	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BMF35_a0322	COG0540	Belongs to the ATCase OTCase family
BMF35_a0323	COG0616	signal peptide processing
BMF35_a0328	COG0471	metal ion transport
BMF35_a0332	COG0457	Tetratricopeptide repeat
BMF35_a0333	COG4948	Mandelate Racemase Muconate Lactonizing
BMF35_a0338	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BMF35_a0340	COG2376	Dihydroxyacetone kinase
BMF35_a0345	COG0330	HflC and HflK could
BMF35_a0346	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BMF35_a0348	COG0318	PFAM AMP-dependent synthetase and ligase
BMF35_a0350	COG2070	2-Nitropropane dioxygenase
BMF35_a0351	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BMF35_a0353	COG0527	aspartate kinase activity
BMF35_a0354	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BMF35_a0355	COG0584	glycerophosphoryl diester phosphodiesterase
BMF35_a0357	COG1393	Belongs to the ArsC family
BMF35_a0359	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BMF35_a0360	COG0217	transcriptional regulatory protein
BMF35_a0364	COG3750	Belongs to the UPF0335 family
BMF35_a0366	COG0469	pyruvate kinase activity
BMF35_a0371	COG2095	MarC family integral membrane protein
BMF35_a0374	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BMF35_a0379	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BMF35_a0383	COG2234	aminopeptidase activity
BMF35_a0386	COG1372	Participates in initiation and elongation during chromosome replication
BMF35_a0386	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BMF35_a0391	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BMF35_a0397	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BMF35_a0397	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BMF35_a0401	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BMF35_a0403	COG1131	(ABC) transporter
BMF35_a0408	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BMF35_a0409	COG1902	pentaerythritol trinitrate reductase activity
BMF35_a0412	COG1988	membrane-bound metal-dependent
BMF35_a0413	COG0519	Catalyzes the synthesis of GMP from XMP
BMF35_a0413	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BMF35_a0417	COG1760	l-serine dehydratase
BMF35_a0418	COG0628	permease
BMF35_a0425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BMF35_a0428	COG1960	acyl-CoA dehydrogenase activity
BMF35_a0430	COG0517	IMP dehydrogenase activity
BMF35_a0430	COG1125	glycine betaine transport
BMF35_a0431	COG1174	glycine betaine transport
BMF35_a0433	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BMF35_a0434	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BMF35_a0436	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BMF35_a0441	COG0189	ligase activity
BMF35_a0442	COG0686	Belongs to the AlaDH PNT family
BMF35_a0453	COG2205	protein histidine kinase activity
BMF35_a0455	COG0433	COG0433 Predicted ATPase
BMF35_a0456	COG0512	Glutamine amidotransferase of anthranilate synthase
BMF35_a0456	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BMF35_a0457	COG0564	pseudouridine synthase activity
BMF35_a0459	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BMF35_a0462	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BMF35_a0462	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BMF35_a0463	COG0688	phosphatidylethanolamine metabolic process
BMF35_a0467	COG0514	ATP-dependent DNA helicase (RecQ)
BMF35_a0470	COG3186	Phenylalanine-4-hydroxylase
BMF35_a0473	COG1968	undecaprenyl-diphosphatase activity
BMF35_a0475	COG1132	(ABC) transporter
BMF35_a0480	COG0297	glycogen (starch) synthase activity
BMF35_a0482	COG0067	glutamate synthase
BMF35_a0482	COG0069	glutamate synthase activity
BMF35_a0482	COG0070	glutamate synthase
BMF35_a0485	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BMF35_a0486	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BMF35_a0496	COG2264	protein methyltransferase activity
BMF35_a0512	COG0489	protein tyrosine kinase activity
BMF35_a0512	COG3206	protein involved in exopolysaccharide biosynthesis
BMF35_a0515	COG0438	transferase activity, transferring glycosyl groups
BMF35_a0516	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BMF35_a0520	COG0495	leucyl-tRNA aminoacylation
BMF35_a0523	COG1028	Short-chain dehydrogenase reductase Sdr
BMF35_a0527	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BMF35_a0528	COG0739	heme binding
BMF35_a0529	COG2833	Protein of unknown function (DUF455)
BMF35_a0530	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BMF35_a0531	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BMF35_a0537	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BMF35_a0540	COG2902	Dehydrogenase
BMF35_a0542	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BMF35_a0543	COG4152	abc transporter atp-binding protein
BMF35_a0545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BMF35_a0548	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
BMF35_a0551	COG0776	regulation of translation
BMF35_a0552	COG2188	Transcriptional regulator
BMF35_a0553	COG3104	oligopeptide transport
BMF35_a0554	COG1228	amidohydrolase
BMF35_a0557	COG0750	zinc metalloprotease
BMF35_a0558	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BMF35_a0561	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BMF35_a0562	COG0138	bifunctional purine biosynthesis protein purh
BMF35_a0568	COG1473	amidohydrolase
BMF35_a0569	COG0840	transmembrane signaling receptor activity
BMF35_a0570	COG5001	Diguanylate cyclase
BMF35_a0571	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BMF35_a0572	COG2201	protein-glutamate methylesterase activity
BMF35_a0573	COG0745	RESPONSE REGULATOR receiver
BMF35_a0581	COG4771	TonB-dependent receptor
BMF35_a0599	COG1401	restriction endodeoxyribonuclease activity
BMF35_a0599	COG1401	restriction endodeoxyribonuclease activity
BMF35_a0613	COG3275	phosphorelay sensor kinase activity
BMF35_a0614	COG3279	Response regulator of the LytR AlgR family
BMF35_a0620	COG0590	tRNA wobble adenosine to inosine editing
BMF35_a0621	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BMF35_a0625	COG1570	exodeoxyribonuclease VII activity
BMF35_a0626	COG0151	Belongs to the GarS family
BMF35_a0627	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BMF35_a0631	COG0316	Belongs to the HesB IscA family
BMF35_a0633	COG2151	metal-sulfur cluster biosynthetic enzyme
BMF35_a0634	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BMF35_a0635	COG0719	Fe-S assembly protein
BMF35_a0637	COG0396	ATPase activity
BMF35_a0640	COG0719	Fe-S assembly protein
BMF35_a0645	COG0167	dihydroorotate dehydrogenase activity
BMF35_a0646	COG0405	Gamma-glutamyltransferase
BMF35_a0650	COG2022	thiamine diphosphate biosynthetic process
BMF35_a0653	COG1612	heme a metabolic process
BMF35_a0654	COG1324	tolerance protein
BMF35_a0656	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BMF35_a0657	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BMF35_a0659	COG1446	asparaginase
BMF35_a0664	COG3275	phosphorelay sensor kinase activity
BMF35_a0671	COG0517	IMP dehydrogenase activity
BMF35_a0672	COG0316	Belongs to the HesB IscA family
BMF35_a0674	COG3773	Cell wall hydrolase
BMF35_a0674	COG3409	Peptidoglycan-binding domain 1 protein
BMF35_a0677	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BMF35_a0678	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BMF35_a0679	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BMF35_a0680	COG0237	dephospho-CoA kinase activity
BMF35_a0681	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BMF35_a0682	COG0424	maF-like protein
BMF35_a0683	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BMF35_a0685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BMF35_a0686	COG1981	membrane
BMF35_a0687	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BMF35_a0691	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BMF35_a0692	COG0445	tRNA wobble uridine modification
BMF35_a0693	COG0357	Ribosomal RNA small subunit methyltransferase G
BMF35_a0697	COG1956	GAF domain-containing protein
BMF35_a0699	COG0009	L-threonylcarbamoyladenylate synthase
BMF35_a0702	COG1329	Transcriptional regulator
BMF35_a0704	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BMF35_a0707	COG0739	heme binding
BMF35_a0708	COG0113	porphobilinogen synthase activity
BMF35_a0711	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BMF35_a0712	COG1793	dna ligase
BMF35_a0713	COG1793	dna ligase
BMF35_a0713	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BMF35_a0720	COG0438	transferase activity, transferring glycosyl groups
BMF35_a0723	COG0739	heme binding
BMF35_a0724	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BMF35_a0725	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BMF35_a0726	COG0799	negative regulation of ribosome biogenesis
BMF35_a0727	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BMF35_a0729	COG0793	Belongs to the peptidase S41A family
BMF35_a0731	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BMF35_a0733	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BMF35_a0734	COG1295	ribonuclease BN
BMF35_a0735	COG0484	heat shock protein binding
BMF35_a0737	COG0259	pyridoxamine-phosphate oxidase activity
BMF35_a0742	COG0482	sulfurtransferase activity
BMF35_a0748	COG2733	membrane
BMF35_a0749	COG2862	Uncharacterized protein family, UPF0114
BMF35_a0751	COG2086	electron transfer activity
BMF35_a0754	COG0045	succinate-CoA ligase (ADP-forming) activity
BMF35_a0755	COG1218	3'(2'),5'-bisphosphate nucleotidase
BMF35_a0757	COG1253	flavin adenine dinucleotide binding
BMF35_a0759	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BMF35_a0760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BMF35_a0761	COG0196	riboflavin kinase activity
BMF35_a0763	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BMF35_a0765	COG0588	phosphoglycerate mutase activity
BMF35_a0772	COG0308	aminopeptidase N
BMF35_a0773	COG1496	oxidoreductase activity
BMF35_a0777	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BMF35_a0780	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BMF35_a0781	COG1192	Involved in chromosome partitioning
BMF35_a0786	COG1201	RNA secondary structure unwinding
BMF35_a0795	COG1494	fructose-1,6-bisphosphatase
BMF35_a0800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BMF35_a0801	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BMF35_a0802	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BMF35_a0803	COG0072	phenylalanine-tRNA ligase activity
BMF35_a0804	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BMF35_a0807	COG0347	Belongs to the P(II) protein family
BMF35_a0808	COG0004	ammonium transporteR
BMF35_a0812	COG1278	Cold shock
BMF35_a0813	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BMF35_a0814	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BMF35_a0817	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BMF35_a0818	COG2032	superoxide dismutase activity
BMF35_a0834	COG4695	Portal protein
BMF35_a0841	COG1764	response to oxidative stress
BMF35_a0843	COG0156	8-amino-7-oxononanoate synthase activity
BMF35_a0854	COG4166	transmembrane transport
BMF35_a0856	COG3483	tryptophan 2,3-dioxygenase activity
BMF35_a0859	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BMF35_a0864	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BMF35_a0865	COG0280	phosphate acetyltransferase
BMF35_a0865	COG0281	malic enzyme
BMF35_a0868	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BMF35_a0870	COG0745	RESPONSE REGULATOR receiver
BMF35_a0874	COG0513	Belongs to the DEAD box helicase family
BMF35_a0875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BMF35_a0876	COG1137	ATPase activity
BMF35_a0879	COG0668	transmembrane transport
BMF35_a0881	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BMF35_a0882	COG0124	histidyl-tRNA synthetase
BMF35_a0883	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BMF35_a0884	COG2890	protein-(glutamine-N5) methyltransferase activity
BMF35_a0886	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BMF35_a0887	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BMF35_a0888	COG2311	Membrane
BMF35_a0889	COG2271	Major facilitator Superfamily
BMF35_a0900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BMF35_a0904	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BMF35_a0904	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BMF35_a0906	COG2367	Beta-lactamase
BMF35_a0913	COG2132	Multicopper oxidase
BMF35_a0914	COG1937	Protein conserved in bacteria
BMF35_a0916	COG0473	3-isopropylmalate dehydrogenase activity
BMF35_a0917	COG0459	protein refolding
BMF35_a0918	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BMF35_a0919	COG0534	Mate efflux family protein
BMF35_a0924	COG0222	ribosome binding
BMF35_a0925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BMF35_a0928	COG3655	Transcriptional regulator
BMF35_a0932	COG3540	Alkaline phosphatase
BMF35_a0934	COG0085	RNA polymerase activity
BMF35_a0935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BMF35_a0938	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BMF35_a0938	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
BMF35_a0940	COG0717	Belongs to the dCTP deaminase family
BMF35_a0942	COG0204	Acyl-transferase
BMF35_a0945	COG2884	Cell division ATP-binding protein ftsE
BMF35_a0953	COG0287	Prephenate dehydrogenase
BMF35_a0954	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BMF35_a0955	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BMF35_a0956	COG2813	Specifically methylates the guanine in position
BMF35_a0956	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BMF35_a0958	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BMF35_a0960	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BMF35_a0964	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BMF35_a0965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BMF35_a0966	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BMF35_a0967	COG0330	HflC and HflK could
BMF35_a0968	COG0330	HflC and HflK could
BMF35_a0969	COG0489	protein tyrosine kinase activity
BMF35_a0971	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BMF35_a0976	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BMF35_a0986	COG4251	negative regulation of phosphorylation
BMF35_a0994	COG0318	PFAM AMP-dependent synthetase and ligase
BMF35_a0999	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BMF35_a1001	COG1115	amino acid carrier protein
BMF35_a1004	COG1228	amidohydrolase
BMF35_a1005	COG3279	Response regulator of the LytR AlgR family
BMF35_a1009	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BMF35_a1010	COG0081	regulation of translation
BMF35_a1012	COG1058	Belongs to the CinA family
BMF35_a1012	COG1546	Belongs to the CinA family
BMF35_a1013	COG2072	flavoprotein involved in K transport
BMF35_a1014	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BMF35_a1018	COG0248	Ppx GppA phosphatase
BMF35_a1019	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BMF35_a1020	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
BMF35_a1023	COG3704	protein secretion by the type IV secretion system
BMF35_a1024	COG3451	type IV secretory pathway VirB4
BMF35_a1025	COG3702	type iv secretory pathway
BMF35_a1027	COG0741	lytic transglycosylase activity
BMF35_a1027	COG1196	nuclear chromosome segregation
BMF35_a1027	COG0739	heme binding
BMF35_a1031	COG0745	RESPONSE REGULATOR receiver
BMF35_a1036	COG1609	Transcriptional regulator
BMF35_a1038	COG1472	Belongs to the glycosyl hydrolase 3 family
BMF35_a1041	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BMF35_a1042	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BMF35_a1044	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BMF35_a1049	COG0489	protein tyrosine kinase activity
BMF35_a1051	COG0438	transferase activity, transferring glycosyl groups
BMF35_a1052	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BMF35_a1053	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BMF35_a1055	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BMF35_a1066	COG1218	3'(2'),5'-bisphosphate nucleotidase
BMF35_a1068	COG0175	sulfate reduction
BMF35_a1072	COG1448	Aminotransferase
BMF35_a1076	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BMF35_a1076	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BMF35_a1079	COG2983	Belongs to the UPF0260 family
BMF35_a1080	COG1999	signal sequence binding
BMF35_a1085	COG0629	single-stranded DNA binding
BMF35_a1093	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BMF35_a1094	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BMF35_a1098	COG0659	secondary active sulfate transmembrane transporter activity
BMF35_a1100	COG5265	(ABC) transporter
BMF35_a1105	COG1215	transferase activity, transferring glycosyl groups
BMF35_a1106	COG1216	Glycosyl transferase, family 2
BMF35_a1108	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BMF35_a1109	COG3001	Fructosamine kinase
BMF35_a1116	COG2197	response regulator
BMF35_a1117	COG4585	Histidine kinase
BMF35_a1123	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BMF35_a1126	COG0783	Belongs to the Dps family
BMF35_a1130	COG2814	Major facilitator Superfamily
BMF35_a1131	COG4989	oxidoreductase activity
BMF35_a1142	COG4946	Tricorn protease homolog
BMF35_a1142	COG0823	Involved in the tonB-independent uptake of proteins
BMF35_a1142	COG1506	peptidase
BMF35_a1146	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BMF35_a1151	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BMF35_a1163	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BMF35_a1178	COG2171	N-acyltransferase activity
BMF35_a1179	COG1404	Belongs to the peptidase S8 family
BMF35_a1180	COG0194	GDP metabolic process
BMF35_a1183	COG0131	Imidazoleglycerol-phosphate dehydratase
BMF35_a1184	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BMF35_a1185	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BMF35_a1186	COG0107	imidazoleglycerol-phosphate synthase activity
BMF35_a1188	COG0140	phosphoribosyl-ATP diphosphatase activity
BMF35_a1190	COG0824	Thioesterase
BMF35_a1194	COG0823	Involved in the tonB-independent uptake of proteins
BMF35_a1195	COG2885	chlorophyll binding
BMF35_a1198	COG0484	heat shock protein binding
BMF35_a1200	COG3850	Histidine kinase
BMF35_a1200	COG2205	protein histidine kinase activity
BMF35_a1200	COG4999	Histidine kinase
BMF35_a1200	COG3437	response regulator, receiver
BMF35_a1202	COG0626	cystathionine gamma-synthase activity
BMF35_a1205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BMF35_a1207	COG0408	coproporphyrinogen oxidase activity
BMF35_a1214	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BMF35_a1215	COG0569	domain protein
BMF35_a1232	COG2319	Wd-40 repeat
BMF35_a1234	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BMF35_a1246	COG1054	Belongs to the UPF0176 family
BMF35_a1248	COG1741	Belongs to the pirin family
BMF35_a1249	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BMF35_a1253	COG2226	methyltransferase
BMF35_a1259	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BMF35_a1260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BMF35_a1262	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BMF35_a1265	COG1335	isochorismatase
BMF35_a1268	COG1012	belongs to the aldehyde dehydrogenase family
BMF35_a1273	COG2814	Major facilitator Superfamily
BMF35_a1276	COG0583	DNA-binding transcription factor activity
BMF35_a1278	COG4771	TonB-dependent receptor
BMF35_a1282	COG1960	acyl-CoA dehydrogenase activity
BMF35_a1283	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BMF35_a1285	COG2188	Transcriptional regulator
BMF35_a1299	COG2130	NADP-dependent
BMF35_a1300	COG2267	carboxylic ester hydrolase activity
BMF35_a1302	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BMF35_a1304	COG1136	(ABC) transporter
BMF35_a1304	COG0577	efflux transmembrane transporter activity
BMF35_a1305	COG0577	efflux transmembrane transporter activity
BMF35_a1305	COG1136	(ABC) transporter
BMF35_a1309	COG0657	acetylesterase activity
BMF35_a1310	COG2885	chlorophyll binding
BMF35_a1310	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BMF35_a1311	COG1960	acyl-CoA dehydrogenase activity
BMF35_a1315	COG2304	oxidoreductase activity
BMF35_a1317	COG2304	oxidoreductase activity
BMF35_a1319	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BMF35_a1320	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BMF35_a1321	COG0181	hydroxymethylbilane synthase activity
BMF35_a1324	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BMF35_a1325	COG4232	protein-disulfide reductase activity
BMF35_a1330	COG0556	nucleotide-excision repair
BMF35_a1334	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BMF35_a1334	COG0596	Alpha beta hydrolase
BMF35_a1334	COG2226	methyltransferase
BMF35_a1335	COG2308	Evidence 4 Homologs of previously reported genes of
BMF35_a1339	COG4566	intracellular signal transduction
BMF35_a1342	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BMF35_a1343	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BMF35_a1349	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BMF35_a1351	COG0252	asparaginase activity
BMF35_a1353	COG0165	Argininosuccinate lyase
BMF35_a1355	COG0019	diaminopimelate decarboxylase activity
BMF35_a1356	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BMF35_a1356	COG1648	precorrin-2 dehydrogenase activity
BMF35_a1360	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BMF35_a1364	COG0736	holo-[acyl-carrier-protein] synthase activity
BMF35_a1365	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BMF35_a1366	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BMF35_a1367	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BMF35_a1368	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BMF35_a1369	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BMF35_a1370	COG0109	protoheme IX farnesyltransferase activity
BMF35_a1372	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BMF35_a1381	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BMF35_a1385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BMF35_a1387	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BMF35_a1388	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BMF35_a1394	COG0418	dihydroorotase activity
BMF35_a1396	COG1012	belongs to the aldehyde dehydrogenase family
BMF35_a1397	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BMF35_a1401	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BMF35_a1404	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BMF35_a1407	COG0789	Transcriptional regulator
BMF35_a1412	COG1196	nuclear chromosome segregation
BMF35_a1419	COG2816	NAD+ diphosphatase activity
BMF35_a1428	COG2239	Acts as a magnesium transporter
BMF35_a1431	COG0583	DNA-binding transcription factor activity
BMF35_a1432	COG1253	flavin adenine dinucleotide binding
BMF35_a1433	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BMF35_a1435	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BMF35_a1438	COG4957	zinc ion binding
BMF35_a1439	COG0456	acetyltransferase
BMF35_a1441	COG0778	Nitroreductase
BMF35_a1442	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BMF35_a1443	COG0612	Peptidase, M16
BMF35_a1444	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BMF35_a1446	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BMF35_a1447	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
BMF35_a1451	COG0625	glutathione transferase activity
BMF35_a1453	COG0443	Heat shock 70 kDa protein
BMF35_a1456	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BMF35_a1460	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BMF35_a1463	COG1381	Involved in DNA repair and RecF pathway recombination
BMF35_a1464	COG0473	3-isopropylmalate dehydrogenase activity
BMF35_a1472	COG2967	ApaG domain
BMF35_a1475	COG3228	Belongs to the MtfA family
BMF35_a1482	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BMF35_a1483	COG0049	tRNA binding
BMF35_a1485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BMF35_a1486	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BMF35_a1487	COG0051	transcription antitermination factor activity, RNA binding
BMF35_a1489	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BMF35_a1490	COG0088	Forms part of the polypeptide exit tunnel
BMF35_a1491	COG0089	rRNA binding
BMF35_a1492	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BMF35_a1493	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BMF35_a1494	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BMF35_a1495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BMF35_a1496	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BMF35_a1497	COG0255	Belongs to the universal ribosomal protein uL29 family
BMF35_a1498	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BMF35_a1499	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BMF35_a1500	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BMF35_a1501	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BMF35_a1502	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BMF35_a1503	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BMF35_a1504	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BMF35_a1505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BMF35_a1506	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BMF35_a1507	COG1841	ribosomal large subunit assembly
BMF35_a1508	COG0200	Binds to the 23S rRNA
BMF35_a1509	COG0201	protein transport
BMF35_a1510	COG0563	adenylate kinase activity
BMF35_a1512	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BMF35_a1513	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BMF35_a1514	COG0202	RNA polymerase activity
BMF35_a1515	COG0203	ribosomal protein L17
BMF35_a1517	COG1505	serine-type exopeptidase activity
BMF35_a1524	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BMF35_a1526	COG0508	dehydrogenase complex catalyzes the overall conversion of
BMF35_a1528	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BMF35_a1530	COG0039	L-malate dehydrogenase activity
BMF35_a1532	COG3300	MHYT domain
BMF35_a1532	COG5001	Diguanylate cyclase
BMF35_a1535	COG4206	TonB-dependent receptor
BMF35_a1537	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BMF35_a1538	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BMF35_a1540	COG0339	signal peptide processing
BMF35_a1543	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BMF35_a1544	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BMF35_a1549	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BMF35_a1550	COG0137	argininosuccinate synthase activity
BMF35_a1552	COG0534	Mate efflux family protein
BMF35_a1553	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BMF35_a1555	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BMF35_a1561	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BMF35_a1564	COG2268	Band 7 protein
BMF35_a1569	COG0741	lytic transglycosylase activity
BMF35_a1570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BMF35_a1572	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BMF35_a1577	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BMF35_a1578	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BMF35_a1581	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BMF35_a1582	COG1278	Cold shock
BMF35_a1584	COG3153	acetyltransferase
BMF35_a1584	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BMF35_a1586	COG0538	isocitrate dehydrogenase activity
BMF35_a1587	COG0644	oxidoreductase
BMF35_a1591	COG1960	acyl-CoA dehydrogenase activity
BMF35_a1592	COG1024	Enoyl-CoA hydratase
BMF35_a1592	COG1250	3-hydroxyacyl-CoA dehydrogenase
BMF35_a1593	COG0183	Belongs to the thiolase family
BMF35_a1594	COG0318	PFAM AMP-dependent synthetase and ligase
BMF35_a1609	COG0742	ribosomal rna small subunit methyltransferase
BMF35_a1610	COG1187	pseudouridine synthase activity
BMF35_a1611	COG2223	nitrite transmembrane transporter activity
BMF35_a1612	COG0285	dihydrofolate synthase activity
BMF35_a1613	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BMF35_a1614	COG0159	tryptophan synthase activity
BMF35_a1616	COG0133	tryptophan synthase activity
BMF35_a1618	COG0135	phosphoribosylanthranilate isomerase activity
BMF35_a1620	COG0284	orotidine-5'-phosphate decarboxylase activity
BMF35_a1622	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BMF35_a1624	COG2003	Belongs to the UPF0758 family
BMF35_a1630	COG0356	it plays a direct role in the translocation of protons across the membrane
BMF35_a1632	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BMF35_a1633	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BMF35_a1636	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BMF35_a1638	COG0539	negative regulation of cytoplasmic translation
BMF35_a1641	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BMF35_a1644	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BMF35_a1646	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BMF35_a1647	COG0228	four-way junction DNA binding
BMF35_a1648	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BMF35_a1654	COG0336	Belongs to the RNA methyltransferase TrmD family
BMF35_a1655	COG0335	large ribosomal subunit rRNA binding
BMF35_a1658	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BMF35_a1664	COG0359	binds to the 23S rRNA
BMF35_a1665	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BMF35_a1666	COG0360	Binds together with S18 to 16S ribosomal RNA
BMF35_a1667	COG2354	Protein conserved in bacteria
BMF35_a1669	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BMF35_a1670	COG1619	proteins homologs of microcin C7 resistance protein MccF
BMF35_a1671	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BMF35_a1675	COG0493	'glutamate synthase
BMF35_a1676	COG5001	Diguanylate cyclase
BMF35_a1677	COG5001	Diguanylate cyclase
BMF35_a1677	COG3300	MHYT domain
BMF35_a1679	COG0481	GTPase activity
BMF35_a1688	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BMF35_a1692	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BMF35_a1695	COG4221	oxidoreductase activity
BMF35_a1697	COG2264	protein methyltransferase activity
BMF35_a1700	COG1028	Short-chain dehydrogenase reductase Sdr
BMF35_a1702	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BMF35_a1705	COG1473	amidohydrolase
BMF35_a1707	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BMF35_a1710	COG1595	DNA-templated transcription, initiation
BMF35_a1711	COG3682	Transcriptional regulator
BMF35_a1714	COG2321	neutral zinc metallopeptidase
BMF35_a1715	COG1028	Short-chain dehydrogenase reductase Sdr
BMF35_a1718	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BMF35_a1720	COG1051	belongs to the nudix hydrolase family
BMF35_a1721	COG0674	pyruvate-flavodoxin oxidoreductase activity
BMF35_a1721	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BMF35_a1722	COG1013	pyruvate-flavodoxin oxidoreductase activity
BMF35_a1723	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BMF35_a1726	COG0415	Belongs to the DNA photolyase family
BMF35_a1727	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BMF35_a1730	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BMF35_a1731	COG0793	Belongs to the peptidase S41A family
BMF35_a1731	COG4946	Tricorn protease homolog
BMF35_a1733	COG4221	oxidoreductase activity
BMF35_a1734	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BMF35_a1739	COG0583	DNA-binding transcription factor activity
BMF35_a1742	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BMF35_a1746	COG1454	alcohol dehydrogenase
BMF35_a1753	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BMF35_a1754	COG0126	phosphoglycerate kinase activity
BMF35_a1757	COG3588	fructose-bisphosphate aldolase
BMF35_a1759	COG0352	thiamine-phosphate diphosphorylase activity
BMF35_a1760	COG1376	ErfK ybiS ycfS ynhG family protein
BMF35_a1761	COG4942	peptidase
BMF35_a1763	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BMF35_a1765	COG0483	inositol monophosphate 1-phosphatase activity
BMF35_a1769	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BMF35_a1770	COG4191	Histidine kinase
BMF35_a1771	COG2204	response regulator
BMF35_a1772	COG0385	Bile acid
BMF35_a1774	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BMF35_a1775	COG0733	neurotransmitter:sodium symporter activity
BMF35_a1779	COG1573	uracil-dna glycosylase
BMF35_a1782	COG0745	RESPONSE REGULATOR receiver
BMF35_a1783	COG0704	Plays a role in the regulation of phosphate uptake
BMF35_a1784	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BMF35_a1786	COG0573	inorganic phosphate transmembrane transporter activity
BMF35_a1788	COG3746	phosphate-selective porin O and P
BMF35_a1790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BMF35_a1793	COG2198	Histidine kinase
BMF35_a1793	COG2205	protein histidine kinase activity
BMF35_a1793	COG0784	Response regulator, receiver
BMF35_a1794	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BMF35_a1797	COG2353	YceI-like domain
BMF35_a1799	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BMF35_a1801	COG0440	acetolactate synthase activity
BMF35_a1802	COG0028	Belongs to the TPP enzyme family
BMF35_a1803	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BMF35_a1804	COG0560	Phosphoserine phosphatase
BMF35_a1807	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BMF35_a1809	COG1722	exodeoxyribonuclease VII activity
BMF35_a1810	COG0142	geranyltranstransferase activity
BMF35_a1811	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BMF35_a1813	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BMF35_a1814	COG1131	(ABC) transporter
BMF35_a1815	COG0842	Transport permease protein
BMF35_a1818	COG0343	queuine tRNA-ribosyltransferase activity
BMF35_a1820	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BMF35_a1824	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BMF35_a1826	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BMF35_a1827	COG0698	ribose 5-phosphate isomerase
BMF35_a1830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BMF35_a1831	COG0358	DNA primase activity
BMF35_a1835	COG0505	Belongs to the CarA family
BMF35_a1837	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BMF35_a1843	COG0148	phosphopyruvate hydratase activity
BMF35_a1844	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BMF35_a1846	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BMF35_a1849	COG1063	alcohol dehydrogenase
BMF35_a1850	COG0156	8-amino-7-oxononanoate synthase activity
BMF35_a1852	COG0772	Belongs to the SEDS family
BMF35_a1857	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BMF35_a1861	COG0288	reversible hydration of carbon dioxide
BMF35_a1864	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BMF35_a1865	COG2867	negative regulation of translational initiation
BMF35_a1866	COG1546	Belongs to the CinA family
BMF35_a1866	COG1058	Belongs to the CinA family
BMF35_a1867	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BMF35_a1867	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BMF35_a1870	COG2204	response regulator
BMF35_a1871	COG5000	phosphorelay sensor kinase activity
BMF35_a1872	COG2204	response regulator
BMF35_a1873	COG1923	regulation of RNA biosynthetic process
BMF35_a1874	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BMF35_a1875	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BMF35_a1877	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BMF35_a1879	COG0012	GTP binding
BMF35_a1883	COG0193	aminoacyl-tRNA hydrolase activity
BMF35_a1884	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BMF35_a1893	COG0752	glycyl-tRNA synthetase alpha subunit
BMF35_a1894	COG0751	glycine-tRNA ligase activity
BMF35_a1895	COG0574	Belongs to the PEP-utilizing enzyme family
BMF35_a1895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BMF35_a1898	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BMF35_a1900	COG2814	Major facilitator Superfamily
BMF35_a1902	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BMF35_a1904	COG3876	Protein conserved in bacteria
BMF35_a1906	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BMF35_a1908	COG0187	DNA topoisomerase II activity
BMF35_a1909	COG0683	leucine binding
BMF35_a1910	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BMF35_a1911	COG0792	nuclease activity
BMF35_a1912	COG0189	ligase activity
BMF35_a1913	COG0586	Pfam SNARE associated Golgi protein
BMF35_a1914	COG4974	Belongs to the 'phage' integrase family
BMF35_a1915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BMF35_a1917	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BMF35_a1918	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BMF35_a1919	COG1420	regulation of RNA biosynthetic process
BMF35_a1920	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BMF35_a1925	COG0443	Heat shock 70 kDa protein
BMF35_a1926	COG0484	heat shock protein binding
BMF35_a1927	COG1752	Esterase of the alpha-beta hydrolase superfamily
BMF35_a1933	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BMF35_a1935	COG0442	prolyl-tRNA aminoacylation
BMF35_a1936	COG2234	aminopeptidase activity
BMF35_a1937	COG0557	exoribonuclease II activity
BMF35_a1940	COG0508	dehydrogenase complex catalyzes the overall conversion of
BMF35_a1941	COG1607	acyl-coa hydrolase
BMF35_a1943	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BMF35_a1945	COG2951	lytic endotransglycosylase activity
BMF35_a1947	COG1686	Belongs to the peptidase S11 family
BMF35_a1948	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BMF35_a1951	COG0084	hydrolase, TatD family'
BMF35_a1952	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BMF35_a1952	COG0321	lipoyl(octanoyl) transferase activity
BMF35_a1953	COG3956	TIGRFAM MazG family protein
BMF35_a1962	COG0022	dehydrogenase e1 component
BMF35_a1962	COG0508	dehydrogenase complex catalyzes the overall conversion of
BMF35_a1963	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BMF35_a1967	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BMF35_a1969	COG0071	Belongs to the small heat shock protein (HSP20) family
BMF35_a1970	COG0504	CTP synthase activity
BMF35_a1972	COG0149	triose-phosphate isomerase activity
BMF35_a1974	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BMF35_a1978	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BMF35_a1979	COG0134	indole-3-glycerol-phosphate synthase activity
BMF35_a1981	COG0315	cyclic pyranopterin monophosphate synthase activity
BMF35_a1982	COG0303	'Molybdopterin
BMF35_a1983	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BMF35_a1984	COG2333	competence protein COMEC
BMF35_a1984	COG0658	competence protein
BMF35_a1985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BMF35_a1986	COG0372	Belongs to the citrate synthase family
BMF35_a1987	COG2205	protein histidine kinase activity
BMF35_a1993	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BMF35_a1995	COG1007	ATP synthesis coupled electron transport
BMF35_a1998	COG0713	ATP synthesis coupled electron transport
BMF35_a2000	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BMF35_a2001	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BMF35_a2005	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BMF35_a2008	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BMF35_a2010	COG0649	NAD binding
BMF35_a2011	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BMF35_a2013	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BMF35_a2014	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BMF35_a2016	COG0183	Belongs to the thiolase family
BMF35_a2019	COG0004	ammonium transporteR
BMF35_a2024	COG2264	protein methyltransferase activity
BMF35_a2027	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BMF35_a2028	COG0860	N-Acetylmuramoyl-L-alanine amidase
BMF35_a2030	COG1530	ribonuclease E activity
BMF35_a2035	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BMF35_a2036	COG0367	asparagine synthase
BMF35_a2041	COG3409	Peptidoglycan-binding domain 1 protein
BMF35_a2041	COG3267	Type II secretory pathway component ExeA
BMF35_a2047	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BMF35_a2052	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BMF35_a2054	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BMF35_a2054	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BMF35_a2056	COG0129	dihydroxy-acid dehydratase activity
BMF35_a2058	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BMF35_a2063	COG0521	Mo-molybdopterin cofactor biosynthetic process
BMF35_a2065	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BMF35_a2065	COG2885	chlorophyll binding
BMF35_a2070	COG1136	(ABC) transporter
BMF35_a2075	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BMF35_a2077	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BMF35_a2080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BMF35_a2081	COG0653	protein targeting
BMF35_a2083	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BMF35_a2084	COG0483	inositol monophosphate 1-phosphatase activity
BMF35_a2086	COG1074	ATP-dependent DNA helicase activity
BMF35_a2088	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BMF35_a2089	COG3178	'Phosphotransferase
BMF35_a2090	COG0802	atpase or kinase
BMF35_a2091	COG2205	protein histidine kinase activity
BMF35_a2093	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BMF35_a2094	COG0678	peroxiredoxin activity
BMF35_a2097	COG0302	gtp cyclohydrolase
BMF35_a2098	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BMF35_a2103	COG4783	chaperone-mediated protein folding
BMF35_a2104	COG0825	malonyl-CoA metabolic process
BMF35_a2105	COG4974	Belongs to the 'phage' integrase family
BMF35_a2108	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BMF35_a2109	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BMF35_a2110	COG1024	Enoyl-CoA hydratase
BMF35_a2115	COG0513	Belongs to the DEAD box helicase family
BMF35_a2117	COG0166	Belongs to the GPI family
BMF35_a2119	COG0681	Belongs to the peptidase S26 family
BMF35_a2120	COG0571	ribonuclease III activity
BMF35_a2121	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BMF35_a2122	COG0745	RESPONSE REGULATOR receiver
BMF35_a2125	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BMF35_a2125	COG1754	DNA topoisomerase type I activity
BMF35_a2126	COG0758	DNA mediated transformation
BMF35_a2127	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BMF35_a2128	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BMF35_a2129	COG0156	8-amino-7-oxononanoate synthase activity
BMF35_a2130	COG3300	MHYT domain
BMF35_a2130	COG5001	Diguanylate cyclase
BMF35_a2132	COG1704	LemA family
BMF35_a2134	COG1899	peptidyl-lysine modification to peptidyl-hypusine
BMF35_a2139	COG0745	RESPONSE REGULATOR receiver
BMF35_a2140	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BMF35_a2141	COG3387	PFAM Glycoside hydrolase 15-related
BMF35_a2143	COG2197	response regulator
BMF35_a2145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BMF35_a2146	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BMF35_a2147	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BMF35_a2150	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BMF35_a2152	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BMF35_a2153	COG0583	DNA-binding transcription factor activity
BMF35_a2155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BMF35_a2156	COG2814	Major facilitator Superfamily
BMF35_a2158	COG1028	Short-chain dehydrogenase reductase Sdr
BMF35_a2161	COG5001	Diguanylate cyclase
BMF35_a2161	COG3300	MHYT domain
BMF35_a2162	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BMF35_a2163	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BMF35_a2164	COG0552	protein localization to endoplasmic reticulum
BMF35_a2165	COG2917	probably involved in intracellular septation
BMF35_a2167	COG3158	transport of potassium into the cell
BMF35_a2169	COG3088	subunit of a heme lyase
BMF35_a2170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BMF35_a2171	COG1138	Cytochrome C-type biogenesis protein
BMF35_a2172	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BMF35_a2174	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BMF35_a2177	COG0254	rRNA binding
BMF35_a2180	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BMF35_a2183	COG0750	zinc metalloprotease
BMF35_a2184	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BMF35_a2186	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BMF35_a2187	COG0233	cytoplasmic translational termination
BMF35_a2188	COG0528	UMP kinase activity
BMF35_a2190	COG1408	metallophosphoesterase
BMF35_a2191	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BMF35_a2192	COG0052	Belongs to the universal ribosomal protein uS2 family
BMF35_a2194	COG0688	phosphatidylethanolamine metabolic process
BMF35_a2195	COG1396	sequence-specific DNA binding
BMF35_a2195	COG3800	Transcriptional regulator
BMF35_a2201	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BMF35_a2203	COG0784	Response regulator, receiver
BMF35_a2203	COG2205	protein histidine kinase activity
BMF35_a2204	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BMF35_a2207	COG0517	IMP dehydrogenase activity
BMF35_a2208	COG2814	Major facilitator Superfamily
BMF35_a2210	COG4771	TonB-dependent receptor
BMF35_a2211	COG1309	transcriptional regulator
BMF35_a2213	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BMF35_a2216	COG0235	Class ii aldolase
BMF35_a2222	COG1643	Atp-dependent helicase
BMF35_a2223	COG0142	geranyltranstransferase activity
BMF35_a2224	COG1605	Chorismate mutase
BMF35_a2224	COG0287	Prephenate dehydrogenase
BMF35_a2229	COG0488	(ABC) transporter
BMF35_a2234	COG0438	transferase activity, transferring glycosyl groups
BMF35_a2235	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BMF35_a2236	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BMF35_a2237	COG1862	Preprotein translocase
BMF35_a2238	COG4770	biotin carboxylase activity
BMF35_a2241	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BMF35_a2241	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BMF35_a2242	COG0346	lactoylglutathione lyase activity
BMF35_a2243	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BMF35_a2247	COG0511	ligase activity, forming carbon-carbon bonds
BMF35_a2248	COG0439	Biotin carboxylase
BMF35_a2251	COG1522	sequence-specific DNA binding
BMF35_a2252	COG2205	protein histidine kinase activity
BMF35_a2256	COG3706	GGDEF domain
BMF35_a2264	COG1047	Peptidyl-prolyl cis-trans
BMF35_a2270	COG3920	Histidine kinase
BMF35_a2272	COG1196	nuclear chromosome segregation
BMF35_a2272	COG3264	Mechanosensitive ion channel
BMF35_a2274	COG1199	ATP-dependent helicase activity
BMF35_a2274	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BMF35_a2277	COG0776	regulation of translation
BMF35_a2278	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BMF35_a2279	COG0416	fatty acid biosynthetic process
BMF35_a2280	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BMF35_a2281	COG3788	relative of glutathione S-transferase, MAPEG superfamily
BMF35_a2282	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BMF35_a2286	COG1012	belongs to the aldehyde dehydrogenase family
BMF35_a2288	COG0215	cysteine-tRNA ligase activity
BMF35_a2298	COG1410	methionine synthase
BMF35_a2298	COG0646	methionine synthase
BMF35_a2300	COG3046	protein related to deoxyribodipyrimidine photolyase
BMF35_a2302	COG1012	belongs to the aldehyde dehydrogenase family
BMF35_a2303	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BMF35_a2303	COG2169	Transcriptional regulator
BMF35_a2306	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BMF35_a2307	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BMF35_a2308	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BMF35_a2309	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BMF35_a2310	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BMF35_a2329	COG0702	epimerase
BMF35_a2330	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BMF35_a2332	COG1404	Belongs to the peptidase S8 family
BMF35_a2341	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BMF35_a2342	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BMF35_a2344	COG1028	Short-chain dehydrogenase reductase Sdr
BMF35_a2345	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BMF35_a2346	COG2133	pyrroloquinoline quinone binding
BMF35_a2350	COG0617	tRNA 3'-terminal CCA addition
BMF35_a2352	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BMF35_a2354	COG0693	protein deglycase activity
BMF35_a2357	COG1104	cysteine desulfurase activity
BMF35_a2359	COG2945	thiolester hydrolase activity
BMF35_a2368	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BMF35_a2369	COG0745	RESPONSE REGULATOR receiver
BMF35_a2370	COG0642	Histidine kinase
BMF35_a2372	COG1660	Displays ATPase and GTPase activities
BMF35_a2373	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BMF35_a2373	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BMF35_a2374	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BMF35_a2375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BMF35_a2376	COG1322	Protein conserved in bacteria
BMF35_a2380	COG0242	peptide deformylase activity
BMF35_a2381	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BMF35_a2382	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BMF35_a2383	COG0101	tRNA pseudouridine synthase activity
BMF35_a2386	COG2234	aminopeptidase activity
BMF35_a2392	COG1741	Belongs to the pirin family
BMF35_a2393	COG0545	Peptidyl-prolyl cis-trans isomerase
BMF35_a2394	COG0596	Alpha beta hydrolase
BMF35_a2395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BMF35_a2396	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BMF35_a2397	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BMF35_a2398	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BMF35_a2399	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BMF35_a2405	COG0322	excinuclease ABC activity
BMF35_a2406	COG0531	amino acid
BMF35_a2407	COG2081	HI0933 family
BMF35_a2409	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BMF35_a2410	COG0424	maF-like protein
BMF35_a2412	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BMF35_a2414	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BMF35_a2415	COG0612	Peptidase, M16
BMF35_a2417	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BMF35_a2418	COG0047	phosphoribosylformylglycinamidine synthase activity
BMF35_a2419	COG5001	Diguanylate cyclase
BMF35_a2420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BMF35_a2422	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BMF35_a2423	COG0546	phosphoglycolate phosphatase activity
BMF35_a2426	COG1045	serine acetyltransferase
BMF35_b0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BMF35_b0002	COG0268	Binds directly to 16S ribosomal RNA
BMF35_b0003	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BMF35_b0004	COG2226	methyltransferase
BMF35_b0005	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BMF35_b0007	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BMF35_b0008	COG0756	dUTP diphosphatase activity
BMF35_b0013	COG0180	Tryptophanyl-tRNA synthetase
BMF35_b0014	COG0728	peptidoglycan biosynthetic process
BMF35_b0015	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BMF35_b0016	COG4395	Tim44
BMF35_b0023	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BMF35_b0024	COG3634	alkyl hydroperoxide reductase activity
BMF35_b0028	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BMF35_b0030	COG0632	four-way junction helicase activity
BMF35_b0032	COG2255	four-way junction helicase activity
BMF35_b0035	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BMF35_b0038	COG2989	Protein conserved in bacteria
BMF35_b0042	COG0123	including yeast histone deacetylase and acetoin utilization protein
BMF35_b0045	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BMF35_b0048	COG2199	diguanylate cyclase activity
BMF35_b0048	COG2200	EAL domain
BMF35_b0048	COG2203	Gaf domain
BMF35_b0049	COG0456	acetyltransferase
BMF35_b0053	COG0714	Associated with various cellular activities
BMF35_b0056	COG0077	Prephenate dehydratase
BMF35_b0057	COG3474	cytochrome
BMF35_b0058	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BMF35_b0064	COG2226	methyltransferase
BMF35_b0065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BMF35_b0074	COG1228	amidohydrolase
BMF35_b0075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BMF35_b0076	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BMF35_b0078	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BMF35_b0082	COG1611	Belongs to the LOG family
BMF35_b0083	COG0351	phosphomethylpyrimidine kinase
BMF35_b0083	COG0352	thiamine-phosphate diphosphorylase activity
BMF35_b0084	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BMF35_b0089	COG2202	Pas domain
BMF35_b0089	COG3920	Histidine kinase
BMF35_b0090	COG0725	ABC transporter, periplasmic molybdate-binding protein
BMF35_b0091	COG4149	molybdate abc transporter
BMF35_b0092	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BMF35_b0094	COG0745	RESPONSE REGULATOR receiver
BMF35_b0095	COG0436	Aminotransferase
BMF35_b0096	COG3243	poly(R)-hydroxyalkanoic acid synthase
BMF35_b0098	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BMF35_b0104	COG0456	acetyltransferase
BMF35_b0106	COG0784	Response regulator, receiver
BMF35_b0108	COG2080	2 iron, 2 sulfur cluster binding
BMF35_b0113	COG0321	lipoyl(octanoyl) transferase activity
BMF35_b0115	COG2301	Belongs to the HpcH HpaI aldolase family
BMF35_b0125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BMF35_b0129	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
BMF35_b0132	COG0037	tRNA processing
BMF35_b0135	COG0800	Aldolase
BMF35_b0136	COG0837	glucose binding
BMF35_b0137	COG0129	dihydroxy-acid dehydratase activity
BMF35_b0138	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BMF35_b0140	COG0432	Pfam Uncharacterised protein family UPF0047
BMF35_b0144	COG0402	S-adenosylhomocysteine deaminase activity
BMF35_b0148	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BMF35_b0150	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BMF35_b0151	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BMF35_b0152	COG1309	transcriptional regulator
BMF35_b0154	COG0577	efflux transmembrane transporter activity
BMF35_b0154	COG1136	(ABC) transporter
BMF35_b0158	COG3551	Protein conserved in bacteria
BMF35_b0162	COG0438	transferase activity, transferring glycosyl groups
BMF35_b0165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BMF35_b0166	COG4771	TonB-dependent receptor
BMF35_b0173	COG0471	metal ion transport
BMF35_b0174	COG0587	DNA-directed DNA polymerase activity
BMF35_b0182	COG1024	Enoyl-CoA hydratase
BMF35_b0183	COG1482	cell wall glycoprotein biosynthetic process
BMF35_b0185	COG0596	Alpha beta hydrolase
BMF35_b0195	COG1758	RNA polymerase activity
BMF35_b0196	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BMF35_b0197	COG0305	Participates in initiation and elongation during chromosome replication
BMF35_b0198	COG5328	Belongs to the UPF0262 family
BMF35_b0201	COG2866	Carboxypeptidase
BMF35_b0204	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BMF35_b0210	COG0606	chelatase, subunit chli
BMF35_b0212	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BMF35_b0213	COG0594	ribonuclease P activity
BMF35_b0214	COG0706	membrane insertase activity
BMF35_b0215	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BMF35_b0216	COG5001	Diguanylate cyclase
BMF35_b0217	COG0625	glutathione transferase activity
BMF35_b0218	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BMF35_b0219	COG1301	dicarboxylic acid transport
BMF35_b0221	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BMF35_b0222	COG0501	Belongs to the peptidase M48B family
BMF35_b0223	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BMF35_b0224	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BMF35_b0227	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2