locus-tag	class	description
AINA4_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AINA4_00030	COG0592	DNA-directed DNA polymerase activity
AINA4_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AINA4_00050	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AINA4_00060	COG0187	DNA topoisomerase II activity
AINA4_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AINA4_00140	COG0457	Tetratricopeptide repeat
AINA4_00140	COG0705	Rhomboid family
AINA4_00160	COG3764	Sortase (surface protein transpeptidase)
AINA4_00190	COG0515	serine threonine protein kinase
AINA4_00200	COG0515	serine threonine protein kinase
AINA4_00210	COG0768	penicillin binding
AINA4_00250	COG1716	ATPase activity
AINA4_00260	COG2205	protein histidine kinase activity
AINA4_00270	COG0745	RESPONSE REGULATOR receiver
AINA4_00300	COG1477	protein flavinylation
AINA4_00360	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AINA4_00390	COG3590	peptidase
AINA4_00400	COG0423	glycine-tRNA ligase activity
AINA4_00460	COG1054	Belongs to the UPF0176 family
AINA4_00470	COG0803	Belongs to the bacterial solute-binding protein 9 family
AINA4_00470	COG3443	Belongs to the bacterial solute-binding protein 9 family
AINA4_00480	COG1121	(ABC) transporter
AINA4_00490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AINA4_00510	COG0735	belongs to the Fur family
AINA4_00520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AINA4_00530	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AINA4_00540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AINA4_00550	COG0776	regulation of translation
AINA4_00580	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AINA4_00600	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AINA4_00660	COG0022	dehydrogenase e1 component
AINA4_00670	COG0508	dehydrogenase complex catalyzes the overall conversion of
AINA4_00680	COG1280	lysine exporter protein (LysE YggA)
AINA4_00700	COG1522	sequence-specific DNA binding
AINA4_00710	COG3158	transport of potassium into the cell
AINA4_00720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AINA4_00740	COG3104	oligopeptide transport
AINA4_00750	COG2267	carboxylic ester hydrolase activity
AINA4_00770	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AINA4_00800	COG0477	Major facilitator Superfamily
AINA4_00810	COG1733	regulation of RNA biosynthetic process
AINA4_00820	COG1876	peptidase activity
AINA4_00840	COG0077	Prephenate dehydratase
AINA4_00850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AINA4_00870	COG1316	TRANSCRIPTIONal
AINA4_00890	COG0513	Belongs to the DEAD box helicase family
AINA4_00930	COG1914	H( )-stimulated, divalent metal cation uptake system
AINA4_00980	COG0646	methionine synthase
AINA4_00980	COG1410	methionine synthase
AINA4_01010	COG1129	ABC transporter
AINA4_01060	COG0038	chloride channel
AINA4_01080	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AINA4_01090	COG0113	porphobilinogen synthase activity
AINA4_01110	COG0181	hydroxymethylbilane synthase activity
AINA4_01120	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AINA4_01130	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AINA4_01140	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AINA4_01150	COG3253	May function as heme-dependent peroxidase
AINA4_01160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AINA4_01170	COG0739	heme binding
AINA4_01170	COG0741	lytic transglycosylase activity
AINA4_01170	COG1196	nuclear chromosome segregation
AINA4_01180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AINA4_01190	COG0037	tRNA processing
AINA4_01210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AINA4_01220	COG0302	gtp cyclohydrolase
AINA4_01240	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AINA4_01250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AINA4_01280	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AINA4_01290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AINA4_01310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AINA4_01320	COG0667	Aldo Keto reductase
AINA4_01380	COG1476	TRANSCRIPTIONal
AINA4_01390	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AINA4_01440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AINA4_01630	COG0085	RNA polymerase activity
AINA4_01640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AINA4_01660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AINA4_01670	COG0049	tRNA binding
AINA4_01680	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AINA4_01690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AINA4_01710	COG0531	amino acid
AINA4_01730	COG0659	secondary active sulfate transmembrane transporter activity
AINA4_01740	COG0051	transcription antitermination factor activity, RNA binding
AINA4_01750	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AINA4_01760	COG0088	Forms part of the polypeptide exit tunnel
AINA4_01770	COG0089	rRNA binding
AINA4_01780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AINA4_01790	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AINA4_01800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AINA4_01810	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AINA4_01820	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AINA4_01830	COG0255	Belongs to the universal ribosomal protein uL29 family
AINA4_01840	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AINA4_01850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AINA4_01860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AINA4_01870	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AINA4_01880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AINA4_01890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AINA4_01900	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AINA4_01910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AINA4_01920	COG1841	ribosomal large subunit assembly
AINA4_01930	COG0200	Binds to the 23S rRNA
AINA4_01950	COG0563	adenylate kinase activity
AINA4_01960	COG0024	Methionine aminopeptidase
AINA4_01970	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AINA4_01980	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AINA4_01990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AINA4_02000	COG0202	RNA polymerase activity
AINA4_02010	COG0203	ribosomal protein L17
AINA4_02020	COG0101	tRNA pseudouridine synthase activity
AINA4_02030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AINA4_02040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AINA4_02050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AINA4_02070	COG1072	(Pantothenic acid kinase))
AINA4_02080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AINA4_02090	COG0736	holo-[acyl-carrier-protein] synthase activity
AINA4_02100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AINA4_02110	COG0802	atpase or kinase
AINA4_02130	COG0456	acetyltransferase
AINA4_02130	COG1214	PFAM Peptidase M22, glycoprotease
AINA4_02140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AINA4_02190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AINA4_02240	COG0519	Catalyzes the synthesis of GMP from XMP
AINA4_02240	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AINA4_02270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AINA4_02280	COG0516	GMP reductase activity
AINA4_02390	COG0513	Belongs to the DEAD box helicase family
AINA4_02400	COG1002	Type II restriction enzyme, methylase subunits
AINA4_02590	COG1132	(ABC) transporter
AINA4_02600	COG1132	(ABC) transporter
AINA4_02610	COG1982	Orn Lys Arg decarboxylase major
AINA4_02620	COG0076	glutamate decarboxylase activity
AINA4_02630	COG0604	alcohol dehydrogenase
AINA4_02640	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AINA4_02640	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AINA4_02650	COG2217	Heavy metal translocating P-type atpase
AINA4_02690	COG3384	dioxygenase
AINA4_02710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AINA4_02720	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AINA4_02770	COG1741	Belongs to the pirin family
AINA4_02800	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AINA4_02830	COG0406	alpha-ribazole phosphatase activity
AINA4_02830	COG0494	nUDIX hydrolase
AINA4_02840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AINA4_02850	COG0745	RESPONSE REGULATOR receiver
AINA4_02880	COG0588	phosphoglycerate mutase activity
AINA4_02920	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AINA4_02920	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AINA4_02930	COG0215	cysteine-tRNA ligase activity
AINA4_02940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AINA4_02980	COG1278	Cold shock
AINA4_02990	COG1470	cell adhesion involved in biofilm formation
AINA4_03000	COG0459	protein refolding
AINA4_03020	COG2205	protein histidine kinase activity
AINA4_03030	COG0745	RESPONSE REGULATOR receiver
AINA4_03070	COG1278	Cold shock
AINA4_03090	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AINA4_03150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AINA4_03220	COG0259	pyridoxamine-phosphate oxidase activity
AINA4_03230	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AINA4_03250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AINA4_03250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AINA4_03260	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AINA4_03290	COG1643	Atp-dependent helicase
AINA4_03300	COG0477	Major facilitator Superfamily
AINA4_03310	COG2040	homocysteine
AINA4_03320	COG1760	l-serine dehydratase
AINA4_03370	COG3842	ATPase activity
AINA4_03380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AINA4_03390	COG0084	hydrolase, TatD family'
AINA4_03400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AINA4_03410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AINA4_03420	COG0488	(ABC) transporter
AINA4_03430	COG1846	Transcriptional regulator
AINA4_03440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AINA4_03450	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AINA4_03470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AINA4_03490	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AINA4_03500	COG0193	aminoacyl-tRNA hydrolase activity
AINA4_03530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AINA4_03550	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AINA4_03580	COG0124	histidyl-tRNA synthetase
AINA4_03590	COG0148	phosphopyruvate hydratase activity
AINA4_03620	COG1404	Belongs to the peptidase S8 family
AINA4_03630	COG1252	NADH dehydrogenase
AINA4_03650	COG2026	Addiction module toxin, RelE StbE family
AINA4_03660	COG2161	toxin-antitoxin pair type II binding
AINA4_03690	COG1704	LemA family
AINA4_03700	COG0501	Belongs to the peptidase M48B family
AINA4_03710	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AINA4_03720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AINA4_03770	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AINA4_03780	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AINA4_03800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AINA4_03810	COG2301	Belongs to the HpcH HpaI aldolase family
AINA4_03840	COG1414	Transcriptional regulator
AINA4_03860	COG0574	Belongs to the PEP-utilizing enzyme family
AINA4_03860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AINA4_03890	COG1028	Short-chain dehydrogenase reductase Sdr
AINA4_03900	COG0633	Ferredoxin
AINA4_03990	COG1414	Transcriptional regulator
AINA4_04000	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AINA4_04020	COG2159	amidohydrolase
AINA4_04080	COG0667	Aldo Keto reductase
AINA4_04090	COG0114	fumarate hydratase activity
AINA4_04100	COG0288	reversible hydration of carbon dioxide
AINA4_04120	COG1722	exodeoxyribonuclease VII activity
AINA4_04130	COG0604	alcohol dehydrogenase
AINA4_04140	COG1570	exodeoxyribonuclease VII activity
AINA4_04150	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AINA4_04170	COG0191	fructose-bisphosphate aldolase activity
AINA4_04200	COG1322	Protein conserved in bacteria
AINA4_04240	COG0012	GTP binding
AINA4_04250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AINA4_04300	COG4221	oxidoreductase activity
AINA4_04320	COG1028	Short-chain dehydrogenase reductase Sdr
AINA4_04380	COG1104	cysteine desulfurase activity
AINA4_04400	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AINA4_04410	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AINA4_04430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AINA4_04440	COG0509	glycine decarboxylation via glycine cleavage system
AINA4_04450	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AINA4_04450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AINA4_04530	COG1217	gtp-binding protein TYPA
AINA4_04540	COG0672	)-iron permease
AINA4_04620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AINA4_04660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AINA4_04670	COG2818	Glycosylase
AINA4_04680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AINA4_04690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AINA4_04710	COG1012	belongs to the aldehyde dehydrogenase family
AINA4_04740	COG2239	Acts as a magnesium transporter
AINA4_04750	COG1012	belongs to the aldehyde dehydrogenase family
AINA4_04780	COG0006	proline dipeptidase activity
AINA4_04790	COG0613	PHP domain protein
AINA4_04810	COG0697	spore germination
AINA4_04830	COG0513	Belongs to the DEAD box helicase family
AINA4_04870	COG1960	acyl-CoA dehydrogenase activity
AINA4_04900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AINA4_04920	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AINA4_04930	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AINA4_04940	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AINA4_04970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AINA4_04980	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AINA4_04990	COG0750	zinc metalloprotease
AINA4_05000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AINA4_05020	COG0442	prolyl-tRNA aminoacylation
AINA4_05050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AINA4_05060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AINA4_05100	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AINA4_05130	COG0196	riboflavin kinase activity
AINA4_05140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AINA4_05160	COG1012	belongs to the aldehyde dehydrogenase family
AINA4_05170	COG1027	Aspartate ammonia-lyase
AINA4_05180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AINA4_05210	COG0531	amino acid
AINA4_05220	COG2188	Transcriptional regulator
AINA4_05230	COG1028	Short-chain dehydrogenase reductase Sdr
AINA4_05240	COG1012	belongs to the aldehyde dehydrogenase family
AINA4_05250	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AINA4_05270	COG0833	amino acid
AINA4_05280	COG0545	Peptidyl-prolyl cis-trans isomerase
AINA4_05300	COG1872	DUF167
AINA4_05340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AINA4_05350	COG1185	polyribonucleotide nucleotidyltransferase activity
AINA4_05360	COG0667	Aldo Keto reductase
AINA4_05370	COG0612	Peptidase, M16
AINA4_05390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AINA4_05420	COG0477	Major facilitator Superfamily
AINA4_05430	COG0052	Belongs to the universal ribosomal protein uS2 family
AINA4_05440	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AINA4_05450	COG0528	UMP kinase activity
AINA4_05460	COG0233	cytoplasmic translational termination
AINA4_05560	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AINA4_05570	COG0366	Alpha amylase catalytic
AINA4_05600	COG0482	sulfurtransferase activity
AINA4_05610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AINA4_05620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AINA4_05630	COG0154	amidase activity
AINA4_05640	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AINA4_05660	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AINA4_05670	COG4721	ABC-type cobalt transport system, permease component
AINA4_05680	COG1122	ATPase activity
AINA4_05730	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AINA4_05740	COG1012	belongs to the aldehyde dehydrogenase family
AINA4_05760	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AINA4_05820	COG1946	Acyl-CoA thioesterase
AINA4_05850	COG0668	transmembrane transport
AINA4_05930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AINA4_05940	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AINA4_05950	COG0544	peptidyl-prolyl cis-trans isomerase activity
AINA4_05980	COG0740	serine-type endopeptidase activity
AINA4_05990	COG0740	serine-type endopeptidase activity
AINA4_06000	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AINA4_06010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AINA4_06020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AINA4_06040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AINA4_06050	COG0131	Imidazoleglycerol-phosphate dehydratase
AINA4_06060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AINA4_06070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AINA4_06100	COG2409	Drug exporters of the RND superfamily
AINA4_06130	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AINA4_06140	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AINA4_06150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AINA4_06160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AINA4_06170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AINA4_06180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AINA4_06180	COG0072	phenylalanine-tRNA ligase activity
AINA4_06200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AINA4_06210	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AINA4_06220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AINA4_06230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AINA4_06250	COG0165	Argininosuccinate lyase
AINA4_06260	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AINA4_06270	COG0367	asparagine synthase
AINA4_06290	COG1794	racemase activity, acting on amino acids and derivatives
AINA4_06320	COG0647	UMP catabolic process
AINA4_06350	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AINA4_06390	COG2079	MmgE PrpD family protein
AINA4_06400	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AINA4_06440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AINA4_06450	COG0497	DNA recombination
AINA4_06460	COG0504	CTP synthase activity
AINA4_06470	COG0494	nUDIX hydrolase
AINA4_06510	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AINA4_06540	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AINA4_06550	COG1160	GTP binding
AINA4_06580	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AINA4_06620	COG0402	S-adenosylhomocysteine deaminase activity
AINA4_06650	COG4702	Belongs to the UPF0303 family
AINA4_06660	COG1280	lysine exporter protein (LysE YggA)
AINA4_06710	COG0697	spore germination
AINA4_06720	COG3046	protein related to deoxyribodipyrimidine photolyase
AINA4_06730	COG0513	Belongs to the DEAD box helicase family
AINA4_06740	COG1716	ATPase activity
AINA4_06770	COG1192	Involved in chromosome partitioning
AINA4_06780	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AINA4_06820	COG1940	carbohydrate kinase activity
AINA4_06840	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AINA4_06850	COG0531	amino acid
AINA4_06860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AINA4_06890	COG0525	valine-tRNA ligase activity
AINA4_06900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AINA4_06910	COG0285	dihydrofolate synthase activity
AINA4_06930	COG0105	UTP biosynthetic process
AINA4_06940	COG0477	Major facilitator Superfamily
AINA4_06960	COG1530	ribonuclease E activity
AINA4_06970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AINA4_06980	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AINA4_06990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AINA4_07000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AINA4_07010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AINA4_07030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AINA4_07050	COG0799	negative regulation of ribosome biogenesis
AINA4_07060	COG2824	Alkylphosphonate utilization operon protein PhnA
AINA4_07080	COG3842	ATPase activity
AINA4_07120	COG1472	Belongs to the glycosyl hydrolase 3 family
AINA4_07130	COG4129	membrane
AINA4_07140	COG1555	photosystem II stabilization
AINA4_07140	COG1596	polysaccharide export
AINA4_07180	COG0268	Binds directly to 16S ribosomal RNA
AINA4_07190	COG0481	GTPase activity
AINA4_07220	COG1420	regulation of RNA biosynthetic process
AINA4_07230	COG0484	heat shock protein binding
AINA4_07240	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AINA4_07250	COG0537	adenosine 5'-monophosphoramidase activity
AINA4_07270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AINA4_07290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AINA4_07300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AINA4_07340	COG0560	Phosphoserine phosphatase
AINA4_07350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AINA4_07360	COG0297	glycogen (starch) synthase activity
AINA4_07370	COG1119	ATPase activity
AINA4_07380	COG0254	rRNA binding
AINA4_07460	COG1968	undecaprenyl-diphosphatase activity
AINA4_07480	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AINA4_07500	COG0545	Peptidyl-prolyl cis-trans isomerase
AINA4_07510	COG2378	regulation of single-species biofilm formation
AINA4_07530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AINA4_07540	COG0805	protein transport
AINA4_07570	COG0587	DNA-directed DNA polymerase activity
AINA4_07580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AINA4_07590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AINA4_07600	COG0167	dihydroorotate dehydrogenase activity
AINA4_07640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AINA4_07650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AINA4_07670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AINA4_07680	COG0723	plastoquinol--plastocyanin reductase activity
AINA4_07690	COG2010	Cytochrome c
AINA4_07700	COG1845	cytochrome c oxidase, subunit III
AINA4_07710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AINA4_07720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AINA4_07730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AINA4_07740	COG0738	Major facilitator superfamily
AINA4_07750	COG0738	Major facilitator superfamily
AINA4_07770	COG1051	belongs to the nudix hydrolase family
AINA4_07780	COG1028	Short-chain dehydrogenase reductase Sdr
AINA4_07790	COG0584	glycerophosphoryl diester phosphodiesterase
AINA4_07800	COG0322	excinuclease ABC activity
AINA4_07820	COG0556	nucleotide-excision repair
AINA4_07830	COG0237	dephospho-CoA kinase activity
AINA4_07840	COG0539	negative regulation of cytoplasmic translation
AINA4_07860	COG2050	protein possibly involved in aromatic compounds catabolism
AINA4_07880	COG0469	pyruvate kinase activity
AINA4_07900	COG0070	glutamate synthase
AINA4_07900	COG0069	glutamate synthase activity
AINA4_07900	COG0067	glutamate synthase
AINA4_07910	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AINA4_07920	COG0159	tryptophan synthase activity
AINA4_07930	COG0133	tryptophan synthase activity
AINA4_07940	COG0134	indole-3-glycerol-phosphate synthase activity
AINA4_07990	COG0107	imidazoleglycerol-phosphate synthase activity
AINA4_08000	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AINA4_08010	COG0140	phosphoribosyl-ATP diphosphatase activity
AINA4_08020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AINA4_08040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AINA4_08060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AINA4_08080	COG1758	RNA polymerase activity
AINA4_08090	COG0194	GDP metabolic process
AINA4_08100	COG0284	orotidine-5'-phosphate decarboxylase activity
AINA4_08110	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AINA4_08120	COG0505	Belongs to the CarA family
AINA4_08140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AINA4_08150	COG0540	Belongs to the ATCase OTCase family
AINA4_08160	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AINA4_08170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AINA4_08180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AINA4_08190	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AINA4_08200	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AINA4_08210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AINA4_08220	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AINA4_08230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AINA4_08250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AINA4_08260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AINA4_08280	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AINA4_08310	COG1196	nuclear chromosome segregation
AINA4_08320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AINA4_08330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AINA4_08340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AINA4_08360	COG2255	four-way junction helicase activity
AINA4_08370	COG0632	four-way junction helicase activity
AINA4_08380	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AINA4_08390	COG0217	transcriptional regulatory protein
AINA4_08400	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AINA4_08410	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AINA4_08430	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AINA4_08520	COG0183	Belongs to the thiolase family
AINA4_08530	COG1024	Enoyl-CoA hydratase
AINA4_08530	COG1250	3-hydroxyacyl-CoA dehydrogenase
AINA4_08540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AINA4_08550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AINA4_08580	COG0756	dUTP diphosphatase activity
AINA4_08640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AINA4_08650	COG0187	DNA topoisomerase II activity
AINA4_08670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AINA4_08690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AINA4_08700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AINA4_08710	COG0508	dehydrogenase complex catalyzes the overall conversion of
AINA4_08730	COG0321	lipoyl(octanoyl) transferase activity
AINA4_08740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AINA4_08770	COG0174	glutamine synthetase
AINA4_08780	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AINA4_08800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AINA4_08800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AINA4_08810	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AINA4_08840	COG1940	carbohydrate kinase activity
AINA4_08870	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AINA4_08900	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AINA4_08930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AINA4_08940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AINA4_08950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AINA4_09000	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AINA4_09010	COG0438	transferase activity, transferring glycosyl groups
AINA4_09030	COG0242	peptide deformylase activity
AINA4_09070	COG0358	DNA primase activity
AINA4_09120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AINA4_09130	COG1381	Involved in DNA repair and RecF pathway recombination
AINA4_09140	COG2860	membrane
AINA4_09180	COG0488	(ABC) transporter
AINA4_09210	COG2151	metal-sulfur cluster biosynthetic enzyme
AINA4_09220	COG0396	ATPase activity
AINA4_09230	COG2146	nitrite reductase [NAD(P)H] activity
AINA4_09270	COG0109	protoheme IX farnesyltransferase activity
AINA4_09290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AINA4_09300	COG0166	Belongs to the GPI family
AINA4_09330	COG0363	glucosamine-6-phosphate deaminase activity
AINA4_09340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AINA4_09360	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AINA4_09370	COG0149	triose-phosphate isomerase activity
AINA4_09380	COG0126	phosphoglycerate kinase activity
AINA4_09390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AINA4_09410	COG1481	regulation of sporulation
AINA4_09420	COG1660	Displays ATPase and GTPase activities
AINA4_09440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AINA4_09470	COG1799	cell septum assembly
AINA4_09480	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AINA4_09490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AINA4_09510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AINA4_09520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AINA4_09540	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AINA4_09550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AINA4_09560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AINA4_09570	COG0768	penicillin binding
AINA4_09590	COG0275	rRNA processing
AINA4_09600	COG2001	Belongs to the MraZ family
AINA4_09620	COG0142	geranyltranstransferase activity
AINA4_09650	COG2815	serine threonine protein kinase
AINA4_09650	COG0515	serine threonine protein kinase
AINA4_09660	COG0495	leucyl-tRNA aminoacylation
AINA4_09710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AINA4_09740	COG2813	Specifically methylates the guanine in position
AINA4_09760	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AINA4_09770	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AINA4_09780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AINA4_09810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AINA4_09830	COG1396	sequence-specific DNA binding
AINA4_09840	COG1058	Belongs to the CinA family
AINA4_09840	COG1546	Belongs to the CinA family
AINA4_09860	COG1674	ftsk spoiiie
AINA4_09870	COG0366	Alpha amylase catalytic
AINA4_09890	COG1175	transmembrane transport
AINA4_09910	COG1609	Transcriptional regulator
AINA4_09920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AINA4_09930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AINA4_09940	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AINA4_09970	COG1090	epimerase
AINA4_10000	COG4974	Belongs to the 'phage' integrase family
AINA4_10030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AINA4_10050	COG0335	large ribosomal subunit rRNA binding
AINA4_10060	COG0336	Belongs to the RNA methyltransferase TrmD family
AINA4_10070	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AINA4_10080	COG1837	Belongs to the UPF0109 family
AINA4_10090	COG0228	four-way junction DNA binding
AINA4_10100	COG1832	CoA-binding protein
AINA4_10110	COG2873	o-acetylhomoserine
AINA4_10130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AINA4_10140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AINA4_10160	COG1116	anion transmembrane transporter activity
AINA4_10210	COG0552	protein localization to endoplasmic reticulum
AINA4_10220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AINA4_10240	COG0742	ribosomal rna small subunit methyltransferase
AINA4_10280	COG1181	Belongs to the D-alanine--D-alanine ligase family
AINA4_10290	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AINA4_10310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AINA4_10320	COG0066	3-isopropylmalate dehydratase activity
AINA4_10330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AINA4_10360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AINA4_10370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AINA4_10380	COG0473	3-isopropylmalate dehydrogenase activity
AINA4_10420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AINA4_10430	COG0440	acetolactate synthase activity
AINA4_10450	COG0129	dihydroxy-acid dehydratase activity
AINA4_10460	COG1082	Xylose isomerase domain protein TIM barrel
AINA4_10480	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AINA4_10500	COG1615	UPF0182 protein
AINA4_10510	COG3480	Lon protease (S16) C-terminal proteolytic domain
AINA4_10560	COG0210	DNA helicase
AINA4_10630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AINA4_10660	COG2252	PERMEase
AINA4_10670	COG2267	carboxylic ester hydrolase activity
AINA4_10690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AINA4_10740	COG0702	epimerase
AINA4_10760	COG2076	Multidrug Resistance protein
AINA4_10780	COG2986	histidine ammonia-lyase
AINA4_10790	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AINA4_10800	COG1228	amidohydrolase
AINA4_10810	COG0010	Belongs to the arginase family
AINA4_10830	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AINA4_10840	COG0483	inositol monophosphate 1-phosphatase activity
AINA4_10870	COG0386	Belongs to the glutathione peroxidase family
AINA4_10890	COG0463	Glycosyl transferase, family 2
AINA4_10930	COG1247	-acetyltransferase
AINA4_10940	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AINA4_10950	COG2177	Part of the ABC transporter FtsEX involved in
AINA4_10960	COG2884	Cell division ATP-binding protein ftsE
AINA4_11000	COG3485	protocatechuate 3,4-dioxygenase
AINA4_11050	COG0433	COG0433 Predicted ATPase
AINA4_11050	COG1674	ftsk spoiiie
AINA4_11090	COG0714	Associated with various cellular activities
AINA4_11120	COG0631	protein serine/threonine phosphatase activity
AINA4_11140	COG1196	nuclear chromosome segregation
AINA4_11150	COG1414	Transcriptional regulator
AINA4_11170	COG2161	toxin-antitoxin pair type II binding
AINA4_11180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AINA4_11190	COG0571	ribonuclease III activity
AINA4_11200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AINA4_11240	COG0586	Pfam SNARE associated Golgi protein
AINA4_11250	COG0384	phenazine biosynthesis protein PhzF
AINA4_11340	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AINA4_11350	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AINA4_11360	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AINA4_11370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AINA4_11380	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AINA4_11390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AINA4_11400	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AINA4_11410	COG0356	it plays a direct role in the translocation of protons across the membrane
AINA4_11430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AINA4_11440	COG0009	L-threonylcarbamoyladenylate synthase
AINA4_11460	COG2890	protein-(glutamine-N5) methyltransferase activity
AINA4_11480	COG1045	serine acetyltransferase
AINA4_11510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AINA4_11520	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AINA4_11550	COG0083	homoserine kinase activity
AINA4_11570	COG0460	homoserine dehydrogenase
AINA4_11590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AINA4_11600	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AINA4_11610	COG0018	arginyl-trna synthetase
AINA4_11670	COG1216	Glycosyl transferase, family 2
AINA4_11790	COG0438	transferase activity, transferring glycosyl groups
AINA4_11830	COG0508	dehydrogenase complex catalyzes the overall conversion of
AINA4_11830	COG0567	Dehydrogenase, E1 component
AINA4_11850	COG1595	DNA-templated transcription, initiation
AINA4_11860	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AINA4_11870	COG1162	GTPase activity
AINA4_11880	COG1088	dTDP-glucose 4,6-dehydratase activity
AINA4_11940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AINA4_11950	COG3594	Acyltransferase
AINA4_11990	COG1250	3-hydroxyacyl-CoA dehydrogenase
AINA4_11990	COG1024	Enoyl-CoA hydratase
AINA4_12000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AINA4_12140	COG0653	protein targeting
AINA4_12170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AINA4_12180	COG5401	PFAM Sporulation and spore germination
AINA4_12190	COG5002	protein histidine kinase activity
AINA4_12190	COG5000	phosphorelay sensor kinase activity
AINA4_12210	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AINA4_12220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AINA4_12310	COG1316	TRANSCRIPTIONal
AINA4_12350	COG0463	Glycosyl transferase, family 2
AINA4_12380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AINA4_12400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AINA4_12410	COG0424	maF-like protein
AINA4_12420	COG4770	biotin carboxylase activity
AINA4_12450	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AINA4_12460	COG0662	Cupin 2, conserved barrel domain protein
AINA4_12460	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AINA4_12470	COG2009	succinate dehydrogenase
AINA4_12490	COG1053	succinate dehydrogenase
AINA4_12500	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AINA4_12520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AINA4_12530	COG1349	DNA-binding transcription factor activity
AINA4_12550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AINA4_12550	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AINA4_12550	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AINA4_12560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AINA4_12610	COG0180	Tryptophanyl-tRNA synthetase
AINA4_12640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AINA4_12640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AINA4_12650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AINA4_12670	COG1132	(ABC) transporter
AINA4_12750	COG0470	DNA polymerase III
AINA4_12760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AINA4_12770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AINA4_12770	COG1754	DNA topoisomerase type I activity
AINA4_12830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AINA4_12860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AINA4_12880	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AINA4_12890	COG1435	thymidine kinase activity
AINA4_12930	COG0579	oxidoreductase
AINA4_12960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AINA4_13060	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AINA4_13080	COG1012	belongs to the aldehyde dehydrogenase family
AINA4_13090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AINA4_13110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AINA4_13140	COG1079	Belongs to the binding-protein-dependent transport system permease family
AINA4_13150	COG4603	Belongs to the binding-protein-dependent transport system permease family
AINA4_13160	COG3845	ABC transporter
AINA4_13170	COG1744	ABC transporter substrate-binding protein PnrA-like
AINA4_13180	COG0137	argininosuccinate synthase activity
AINA4_13190	COG0673	inositol 2-dehydrogenase activity
AINA4_13200	COG1940	carbohydrate kinase activity
AINA4_13210	COG2115	Belongs to the xylose isomerase family
AINA4_13220	COG1070	Carbohydrate kinase
AINA4_13230	COG4213	ABC transporter substrate-binding protein
AINA4_13250	COG4214	carbohydrate transport
AINA4_13280	COG0222	ribosome binding
AINA4_13290	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AINA4_13300	COG1105	Belongs to the carbohydrate kinase PfkB family
AINA4_13310	COG2205	protein histidine kinase activity
AINA4_13320	COG0745	RESPONSE REGULATOR receiver
AINA4_13350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AINA4_13360	COG0081	regulation of translation
AINA4_13370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AINA4_13390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AINA4_13400	COG0436	Aminotransferase
AINA4_13420	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AINA4_13440	COG2030	dehydratase
AINA4_13450	COG0076	glutamate decarboxylase activity
AINA4_13460	COG2957	Belongs to the agmatine deiminase family
AINA4_13480	COG1064	alcohol dehydrogenase
AINA4_13520	COG2078	PFAM AMMECR1 domain protein
AINA4_13520	COG3885	ferrous iron binding
AINA4_13540	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AINA4_13550	COG1846	Transcriptional regulator
AINA4_13570	COG0505	Belongs to the CarA family
AINA4_13580	COG0519	Catalyzes the synthesis of GMP from XMP
AINA4_13590	COG0174	glutamine synthetase
AINA4_13630	COG1834	amidinotransferase
AINA4_13640	COG0138	bifunctional purine biosynthesis protein purh
AINA4_13690	COG0045	succinate-CoA ligase (ADP-forming) activity
AINA4_13720	COG0584	glycerophosphoryl diester phosphodiesterase
AINA4_13770	COG0387	Pfam Sodium calcium exchanger
AINA4_13780	COG0366	Alpha amylase catalytic
AINA4_13840	COG2838	Isocitrate dehydrogenase
AINA4_13850	COG2409	Drug exporters of the RND superfamily
AINA4_13880	COG1666	GTP binding
AINA4_13890	COG2272	Belongs to the type-B carboxylesterase lipase family
AINA4_13910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AINA4_13920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AINA4_13940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AINA4_14020	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AINA4_14040	COG0151	Belongs to the GarS family
AINA4_14050	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AINA4_14060	COG2364	Membrane
AINA4_14090	COG0366	Alpha amylase catalytic
AINA4_14100	COG3483	tryptophan 2,3-dioxygenase activity
AINA4_14130	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AINA4_14140	COG0047	phosphoribosylformylglycinamidine synthase activity
AINA4_14160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AINA4_14170	COG0656	L-ascorbic acid biosynthetic process
AINA4_14200	COG1605	Chorismate mutase
AINA4_14200	COG0287	Prephenate dehydrogenase
AINA4_14210	COG0697	spore germination
AINA4_14220	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AINA4_14240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AINA4_14250	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AINA4_14270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AINA4_14280	COG0531	amino acid
AINA4_14290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AINA4_14300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AINA4_14320	COG0730	response to heat
AINA4_14330	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AINA4_14340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AINA4_14370	COG0142	geranyltranstransferase activity
AINA4_14380	COG2226	methyltransferase
AINA4_14400	COG1169	isochorismate synthase
AINA4_14410	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AINA4_14460	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AINA4_14470	COG4948	Mandelate Racemase Muconate Lactonizing
AINA4_14480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AINA4_14490	COG1333	cytochrome c biogenesis protein
AINA4_14500	COG0785	Cytochrome C biogenesis protein
AINA4_14510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AINA4_14520	COG0406	alpha-ribazole phosphatase activity
AINA4_14530	COG0017	Asparaginyl-tRNA synthetase
AINA4_14540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AINA4_14590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AINA4_14600	COG0569	domain protein
AINA4_14610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AINA4_14630	COG0590	tRNA wobble adenosine to inosine editing
AINA4_14640	COG0745	RESPONSE REGULATOR receiver
AINA4_14650	COG0415	Belongs to the DNA photolyase family
AINA4_14670	COG1305	Transglutaminase-like
AINA4_14730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AINA4_14770	COG1231	oxidoreductase activity
AINA4_14780	COG0009	L-threonylcarbamoyladenylate synthase
AINA4_14800	COG0300	oxidoreductase activity
AINA4_14810	COG1305	Transglutaminase-like
AINA4_14850	COG1028	Short-chain dehydrogenase reductase Sdr
AINA4_14870	COG0577	efflux transmembrane transporter activity
AINA4_14870	COG1136	(ABC) transporter
AINA4_14880	COG1136	(ABC) transporter
AINA4_14910	COG1309	transcriptional regulator
AINA4_14940	COG0542	response to heat
AINA4_14950	COG2813	Specifically methylates the guanine in position
AINA4_14980	COG0789	Transcriptional regulator
AINA4_14990	COG0484	heat shock protein binding
AINA4_15000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AINA4_15010	COG0443	Heat shock 70 kDa protein
AINA4_15090	COG0142	geranyltranstransferase activity
AINA4_15100	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AINA4_15110	COG0717	Belongs to the dCTP deaminase family
AINA4_15140	COG0305	Participates in initiation and elongation during chromosome replication
AINA4_15150	COG0359	binds to the 23S rRNA
AINA4_15160	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AINA4_15180	COG0360	Binds together with S18 to 16S ribosomal RNA
AINA4_15200	COG0617	tRNA 3'-terminal CCA addition
AINA4_15230	COG0492	ferredoxin-NADP+ reductase activity
AINA4_15240	COG3118	belongs to the thioredoxin family
AINA4_15250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AINA4_15290	COG0357	Ribosomal RNA small subunit methyltransferase G
AINA4_15310	COG0706	membrane insertase activity
AINA4_15330	COG0230	Belongs to the bacterial ribosomal protein bL34 family