locus-tag	class	description
AURUGA1_00001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AURUGA1_00002	COG0592	DNA-directed DNA polymerase activity
AURUGA1_00003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AURUGA1_00004	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AURUGA1_00005	COG0187	DNA topoisomerase II activity
AURUGA1_00006	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AURUGA1_00014	COG0457	Tetratricopeptide repeat
AURUGA1_00014	COG0705	Rhomboid family
AURUGA1_00016	COG3764	Sortase (surface protein transpeptidase)
AURUGA1_00019	COG0515	serine threonine protein kinase
AURUGA1_00020	COG0515	serine threonine protein kinase
AURUGA1_00021	COG0768	penicillin binding
AURUGA1_00025	COG1716	ATPase activity
AURUGA1_00031	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AURUGA1_00034	COG3590	peptidase
AURUGA1_00035	COG0423	glycine-tRNA ligase activity
AURUGA1_00042	COG3443	Belongs to the bacterial solute-binding protein 9 family
AURUGA1_00042	COG0803	Belongs to the bacterial solute-binding protein 9 family
AURUGA1_00043	COG1121	(ABC) transporter
AURUGA1_00044	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AURUGA1_00046	COG0735	belongs to the Fur family
AURUGA1_00047	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AURUGA1_00048	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AURUGA1_00049	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AURUGA1_00050	COG0776	regulation of translation
AURUGA1_00053	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AURUGA1_00054	COG3011	Protein conserved in bacteria
AURUGA1_00055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AURUGA1_00060	COG0022	dehydrogenase e1 component
AURUGA1_00061	COG0508	dehydrogenase complex catalyzes the overall conversion of
AURUGA1_00062	COG1280	lysine exporter protein (LysE YggA)
AURUGA1_00064	COG1522	sequence-specific DNA binding
AURUGA1_00065	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AURUGA1_00067	COG3104	oligopeptide transport
AURUGA1_00068	COG2267	carboxylic ester hydrolase activity
AURUGA1_00070	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AURUGA1_00072	COG0477	Major facilitator Superfamily
AURUGA1_00073	COG1733	regulation of RNA biosynthetic process
AURUGA1_00074	COG1876	peptidase activity
AURUGA1_00076	COG0077	Prephenate dehydratase
AURUGA1_00077	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AURUGA1_00080	COG1316	TRANSCRIPTIONal
AURUGA1_00083	COG0513	Belongs to the DEAD box helicase family
AURUGA1_00087	COG1914	H( )-stimulated, divalent metal cation uptake system
AURUGA1_00090	COG2326	polyphosphate kinase activity
AURUGA1_00092	COG0412	Dienelactone hydrolase
AURUGA1_00093	COG1410	methionine synthase
AURUGA1_00093	COG0646	methionine synthase
AURUGA1_00096	COG4172	Belongs to the ABC transporter superfamily
AURUGA1_00100	COG0038	chloride channel
AURUGA1_00102	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AURUGA1_00103	COG0113	porphobilinogen synthase activity
AURUGA1_00105	COG0181	hydroxymethylbilane synthase activity
AURUGA1_00106	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AURUGA1_00107	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AURUGA1_00114	COG0739	heme binding
AURUGA1_00114	COG1196	nuclear chromosome segregation
AURUGA1_00114	COG0741	lytic transglycosylase activity
AURUGA1_00115	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AURUGA1_00116	COG0037	tRNA processing
AURUGA1_00118	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AURUGA1_00119	COG0302	gtp cyclohydrolase
AURUGA1_00121	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AURUGA1_00122	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AURUGA1_00125	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AURUGA1_00126	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AURUGA1_00128	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AURUGA1_00129	COG0667	Aldo Keto reductase
AURUGA1_00133	COG0542	response to heat
AURUGA1_00134	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AURUGA1_00139	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AURUGA1_00142	COG4566	intracellular signal transduction
AURUGA1_00156	COG0085	RNA polymerase activity
AURUGA1_00157	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AURUGA1_00159	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AURUGA1_00160	COG0049	tRNA binding
AURUGA1_00161	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AURUGA1_00162	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AURUGA1_00164	COG0659	secondary active sulfate transmembrane transporter activity
AURUGA1_00165	COG0051	transcription antitermination factor activity, RNA binding
AURUGA1_00166	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AURUGA1_00167	COG0088	Forms part of the polypeptide exit tunnel
AURUGA1_00168	COG0089	rRNA binding
AURUGA1_00169	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AURUGA1_00170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AURUGA1_00171	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AURUGA1_00172	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AURUGA1_00173	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AURUGA1_00174	COG0255	Belongs to the universal ribosomal protein uL29 family
AURUGA1_00175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AURUGA1_00176	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AURUGA1_00177	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AURUGA1_00178	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AURUGA1_00179	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AURUGA1_00180	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AURUGA1_00181	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AURUGA1_00182	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AURUGA1_00183	COG1841	ribosomal large subunit assembly
AURUGA1_00184	COG0200	Binds to the 23S rRNA
AURUGA1_00186	COG0563	adenylate kinase activity
AURUGA1_00187	COG0024	Methionine aminopeptidase
AURUGA1_00189	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AURUGA1_00190	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AURUGA1_00191	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AURUGA1_00192	COG0202	RNA polymerase activity
AURUGA1_00193	COG0203	ribosomal protein L17
AURUGA1_00194	COG0101	tRNA pseudouridine synthase activity
AURUGA1_00195	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AURUGA1_00196	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AURUGA1_00197	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AURUGA1_00198	COG1072	(Pantothenic acid kinase))
AURUGA1_00199	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AURUGA1_00200	COG0736	holo-[acyl-carrier-protein] synthase activity
AURUGA1_00201	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AURUGA1_00202	COG0802	atpase or kinase
AURUGA1_00204	COG1214	PFAM Peptidase M22, glycoprotease
AURUGA1_00204	COG0456	acetyltransferase
AURUGA1_00205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AURUGA1_00209	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AURUGA1_00217	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AURUGA1_00217	COG0519	Catalyzes the synthesis of GMP from XMP
AURUGA1_00220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AURUGA1_00221	COG0516	GMP reductase activity
AURUGA1_00225	COG0411	ABC transporter
AURUGA1_00228	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AURUGA1_00254	COG1132	(ABC) transporter
AURUGA1_00255	COG1132	(ABC) transporter
AURUGA1_00256	COG1982	Orn Lys Arg decarboxylase major
AURUGA1_00257	COG0076	glutamate decarboxylase activity
AURUGA1_00259	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AURUGA1_00259	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AURUGA1_00260	COG2217	Heavy metal translocating P-type atpase
AURUGA1_00264	COG3384	dioxygenase
AURUGA1_00267	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AURUGA1_00268	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AURUGA1_00272	COG1741	Belongs to the pirin family
AURUGA1_00275	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AURUGA1_00279	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AURUGA1_00280	COG0745	RESPONSE REGULATOR receiver
AURUGA1_00284	COG0588	phosphoglycerate mutase activity
AURUGA1_00288	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AURUGA1_00288	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AURUGA1_00289	COG0215	cysteine-tRNA ligase activity
AURUGA1_00290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AURUGA1_00295	COG1278	Cold shock
AURUGA1_00296	COG1470	cell adhesion involved in biofilm formation
AURUGA1_00297	COG0459	protein refolding
AURUGA1_00299	COG5002	protein histidine kinase activity
AURUGA1_00300	COG0745	RESPONSE REGULATOR receiver
AURUGA1_00304	COG1278	Cold shock
AURUGA1_00306	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AURUGA1_00314	COG1982	Orn Lys Arg decarboxylase major
AURUGA1_00316	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AURUGA1_00323	COG0259	pyridoxamine-phosphate oxidase activity
AURUGA1_00324	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AURUGA1_00326	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AURUGA1_00326	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AURUGA1_00327	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AURUGA1_00329	COG1643	Atp-dependent helicase
AURUGA1_00331	COG2040	homocysteine
AURUGA1_00332	COG1760	l-serine dehydratase
AURUGA1_00337	COG3842	ATPase activity
AURUGA1_00338	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AURUGA1_00339	COG0084	hydrolase, TatD family'
AURUGA1_00340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AURUGA1_00341	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AURUGA1_00342	COG0488	(ABC) transporter
AURUGA1_00343	COG1846	Transcriptional regulator
AURUGA1_00345	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AURUGA1_00346	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AURUGA1_00350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AURUGA1_00351	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AURUGA1_00352	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AURUGA1_00353	COG0193	aminoacyl-tRNA hydrolase activity
AURUGA1_00356	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AURUGA1_00358	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AURUGA1_00361	COG0124	histidyl-tRNA synthetase
AURUGA1_00362	COG0148	phosphopyruvate hydratase activity
AURUGA1_00365	COG1404	Belongs to the peptidase S8 family
AURUGA1_00366	COG1252	NADH dehydrogenase
AURUGA1_00368	COG4974	Belongs to the 'phage' integrase family
AURUGA1_00386	COG1704	LemA family
AURUGA1_00387	COG0501	Belongs to the peptidase M48B family
AURUGA1_00388	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AURUGA1_00389	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AURUGA1_00394	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AURUGA1_00395	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AURUGA1_00397	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AURUGA1_00398	COG2301	Belongs to the HpcH HpaI aldolase family
AURUGA1_00401	COG1414	Transcriptional regulator
AURUGA1_00403	COG0574	Belongs to the PEP-utilizing enzyme family
AURUGA1_00403	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AURUGA1_00406	COG1028	Short-chain dehydrogenase reductase Sdr
AURUGA1_00407	COG0633	Ferredoxin
AURUGA1_00414	COG1414	Transcriptional regulator
AURUGA1_00415	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AURUGA1_00417	COG2159	amidohydrolase
AURUGA1_00423	COG0667	Aldo Keto reductase
AURUGA1_00424	COG0114	fumarate hydratase activity
AURUGA1_00425	COG0288	reversible hydration of carbon dioxide
AURUGA1_00427	COG1722	exodeoxyribonuclease VII activity
AURUGA1_00428	COG0604	alcohol dehydrogenase
AURUGA1_00429	COG1570	exodeoxyribonuclease VII activity
AURUGA1_00430	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AURUGA1_00432	COG0191	fructose-bisphosphate aldolase activity
AURUGA1_00433	COG1494	fructose-1,6-bisphosphatase
AURUGA1_00435	COG1322	Protein conserved in bacteria
AURUGA1_00436	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AURUGA1_00439	COG3718	enzyme involved in inositol metabolism
AURUGA1_00440	COG3962	Belongs to the TPP enzyme family
AURUGA1_00443	COG1082	Xylose isomerase domain protein TIM barrel
AURUGA1_00445	COG1172	Belongs to the binding-protein-dependent transport system permease family
AURUGA1_00446	COG1129	ABC transporter
AURUGA1_00449	COG2188	Transcriptional regulator
AURUGA1_00450	COG0673	inositol 2-dehydrogenase activity
AURUGA1_00452	COG1607	acyl-coa hydrolase
AURUGA1_00453	COG0012	GTP binding
AURUGA1_00458	COG4221	oxidoreductase activity
AURUGA1_00460	COG4221	oxidoreductase activity
AURUGA1_00466	COG1104	cysteine desulfurase activity
AURUGA1_00468	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AURUGA1_00469	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AURUGA1_00471	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AURUGA1_00472	COG0509	glycine decarboxylation via glycine cleavage system
AURUGA1_00473	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AURUGA1_00473	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AURUGA1_00479	COG4166	transmembrane transport
AURUGA1_00480	COG0601	transmembrane transport
AURUGA1_00481	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AURUGA1_00484	COG0672	)-iron permease
AURUGA1_00490	COG2171	N-acyltransferase activity
AURUGA1_00491	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AURUGA1_00495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AURUGA1_00496	COG2818	Glycosylase
AURUGA1_00497	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AURUGA1_00498	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AURUGA1_00500	COG1012	belongs to the aldehyde dehydrogenase family
AURUGA1_00503	COG2239	Acts as a magnesium transporter
AURUGA1_00505	COG0583	DNA-binding transcription factor activity
AURUGA1_00507	COG0006	proline dipeptidase activity
AURUGA1_00508	COG0613	PHP domain protein
AURUGA1_00510	COG0697	spore germination
AURUGA1_00512	COG0513	Belongs to the DEAD box helicase family
AURUGA1_00516	COG1960	acyl-CoA dehydrogenase activity
AURUGA1_00519	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AURUGA1_00521	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AURUGA1_00522	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AURUGA1_00523	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AURUGA1_00526	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AURUGA1_00527	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AURUGA1_00528	COG0750	zinc metalloprotease
AURUGA1_00529	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AURUGA1_00531	COG0442	prolyl-tRNA aminoacylation
AURUGA1_00534	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AURUGA1_00535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AURUGA1_00539	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AURUGA1_00542	COG0196	riboflavin kinase activity
AURUGA1_00543	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AURUGA1_00544	COG1012	belongs to the aldehyde dehydrogenase family
AURUGA1_00545	COG1027	Aspartate ammonia-lyase
AURUGA1_00546	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AURUGA1_00549	COG0531	amino acid
AURUGA1_00550	COG2188	Transcriptional regulator
AURUGA1_00551	COG1028	Short-chain dehydrogenase reductase Sdr
AURUGA1_00552	COG1012	belongs to the aldehyde dehydrogenase family
AURUGA1_00553	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AURUGA1_00555	COG0833	amino acid
AURUGA1_00556	COG0545	Peptidyl-prolyl cis-trans isomerase
AURUGA1_00558	COG1872	DUF167
AURUGA1_00561	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AURUGA1_00562	COG1185	polyribonucleotide nucleotidyltransferase activity
AURUGA1_00563	COG0667	Aldo Keto reductase
AURUGA1_00564	COG0612	Peptidase, M16
AURUGA1_00566	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AURUGA1_00569	COG0477	Major facilitator Superfamily
AURUGA1_00570	COG0052	Belongs to the universal ribosomal protein uS2 family
AURUGA1_00571	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AURUGA1_00572	COG0528	UMP kinase activity
AURUGA1_00573	COG0233	cytoplasmic translational termination
AURUGA1_00583	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AURUGA1_00584	COG0366	Alpha amylase catalytic
AURUGA1_00587	COG0482	sulfurtransferase activity
AURUGA1_00588	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AURUGA1_00590	COG1309	transcriptional regulator
AURUGA1_00591	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AURUGA1_00592	COG0154	amidase activity
AURUGA1_00593	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AURUGA1_00596	COG4721	ABC-type cobalt transport system, permease component
AURUGA1_00597	COG1122	ATPase activity
AURUGA1_00603	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AURUGA1_00604	COG1012	belongs to the aldehyde dehydrogenase family
AURUGA1_00607	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AURUGA1_00613	COG1946	Acyl-CoA thioesterase
AURUGA1_00616	COG0668	transmembrane transport
AURUGA1_00618	COG0698	ribose 5-phosphate isomerase
AURUGA1_00622	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AURUGA1_00623	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AURUGA1_00626	COG0544	peptidyl-prolyl cis-trans isomerase activity
AURUGA1_00629	COG0740	serine-type endopeptidase activity
AURUGA1_00630	COG0740	serine-type endopeptidase activity
AURUGA1_00631	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AURUGA1_00632	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AURUGA1_00633	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AURUGA1_00635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AURUGA1_00636	COG0131	Imidazoleglycerol-phosphate dehydratase
AURUGA1_00637	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AURUGA1_00638	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AURUGA1_00641	COG2409	Drug exporters of the RND superfamily
AURUGA1_00644	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AURUGA1_00645	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AURUGA1_00646	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AURUGA1_00647	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AURUGA1_00648	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AURUGA1_00649	COG0072	phenylalanine-tRNA ligase activity
AURUGA1_00649	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AURUGA1_00651	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AURUGA1_00652	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AURUGA1_00653	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AURUGA1_00654	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AURUGA1_00656	COG0165	Argininosuccinate lyase
AURUGA1_00657	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AURUGA1_00658	COG0367	asparagine synthase
AURUGA1_00660	COG1794	racemase activity, acting on amino acids and derivatives
AURUGA1_00666	COG0647	UMP catabolic process
AURUGA1_00667	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AURUGA1_00670	COG1802	Transcriptional regulator
AURUGA1_00671	COG2079	MmgE PrpD family protein
AURUGA1_00672	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AURUGA1_00676	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AURUGA1_00677	COG0497	DNA recombination
AURUGA1_00678	COG0504	CTP synthase activity
AURUGA1_00679	COG0494	nUDIX hydrolase
AURUGA1_00682	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AURUGA1_00683	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AURUGA1_00686	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AURUGA1_00687	COG1160	GTP binding
AURUGA1_00697	COG0402	S-adenosylhomocysteine deaminase activity
AURUGA1_00700	COG4702	Belongs to the UPF0303 family
AURUGA1_00701	COG1280	lysine exporter protein (LysE YggA)
AURUGA1_00705	COG0697	spore germination
AURUGA1_00706	COG3046	protein related to deoxyribodipyrimidine photolyase
AURUGA1_00707	COG0513	Belongs to the DEAD box helicase family
AURUGA1_00708	COG1716	ATPase activity
AURUGA1_00711	COG1192	Involved in chromosome partitioning
AURUGA1_00712	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AURUGA1_00717	COG1940	carbohydrate kinase activity
AURUGA1_00719	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AURUGA1_00720	COG0531	amino acid
AURUGA1_00724	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AURUGA1_00727	COG0525	valine-tRNA ligase activity
AURUGA1_00728	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AURUGA1_00729	COG0285	dihydrofolate synthase activity
AURUGA1_00731	COG0105	UTP biosynthetic process
AURUGA1_00732	COG2814	Major facilitator Superfamily
AURUGA1_00738	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AURUGA1_00742	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AURUGA1_00743	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AURUGA1_00744	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AURUGA1_00745	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AURUGA1_00747	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AURUGA1_00749	COG0799	negative regulation of ribosome biogenesis
AURUGA1_00751	COG2824	Alkylphosphonate utilization operon protein PhnA
AURUGA1_00753	COG3842	ATPase activity
AURUGA1_00757	COG1472	Belongs to the glycosyl hydrolase 3 family
AURUGA1_00758	COG4129	membrane
AURUGA1_00759	COG1555	photosystem II stabilization
AURUGA1_00759	COG1596	polysaccharide export
AURUGA1_00762	COG0268	Binds directly to 16S ribosomal RNA
AURUGA1_00763	COG0481	GTPase activity
AURUGA1_00766	COG1420	regulation of RNA biosynthetic process
AURUGA1_00767	COG0484	heat shock protein binding
AURUGA1_00768	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AURUGA1_00769	COG0537	adenosine 5'-monophosphoramidase activity
AURUGA1_00771	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AURUGA1_00773	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AURUGA1_00774	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AURUGA1_00778	COG0560	Phosphoserine phosphatase
AURUGA1_00779	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AURUGA1_00780	COG0297	glycogen (starch) synthase activity
AURUGA1_00781	COG1119	ATPase activity
AURUGA1_00782	COG0254	rRNA binding
AURUGA1_00791	COG1968	undecaprenyl-diphosphatase activity
AURUGA1_00793	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AURUGA1_00795	COG0545	Peptidyl-prolyl cis-trans isomerase
AURUGA1_00796	COG2378	regulation of single-species biofilm formation
AURUGA1_00798	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AURUGA1_00799	COG0805	protein transport
AURUGA1_00800	COG4581	dead DEAH box helicase
AURUGA1_00802	COG0587	DNA-directed DNA polymerase activity
AURUGA1_00803	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AURUGA1_00804	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AURUGA1_00805	COG0167	dihydroorotate dehydrogenase activity
AURUGA1_00807	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AURUGA1_00809	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AURUGA1_00810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AURUGA1_00812	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AURUGA1_00813	COG0723	plastoquinol--plastocyanin reductase activity
AURUGA1_00814	COG2010	Cytochrome c
AURUGA1_00815	COG1845	cytochrome c oxidase, subunit III
AURUGA1_00816	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AURUGA1_00817	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AURUGA1_00818	COG0738	Major facilitator superfamily
AURUGA1_00819	COG0738	Major facilitator superfamily
AURUGA1_00821	COG0494	nUDIX hydrolase
AURUGA1_00822	COG1028	Short-chain dehydrogenase reductase Sdr
AURUGA1_00823	COG0584	glycerophosphoryl diester phosphodiesterase
AURUGA1_00824	COG0322	excinuclease ABC activity
AURUGA1_00826	COG0556	nucleotide-excision repair
AURUGA1_00827	COG0237	dephospho-CoA kinase activity
AURUGA1_00828	COG0539	negative regulation of cytoplasmic translation
AURUGA1_00830	COG2050	protein possibly involved in aromatic compounds catabolism
AURUGA1_00833	COG0469	pyruvate kinase activity
AURUGA1_00835	COG0069	glutamate synthase activity
AURUGA1_00835	COG0070	glutamate synthase
AURUGA1_00835	COG0067	glutamate synthase
AURUGA1_00836	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AURUGA1_00837	COG0159	tryptophan synthase activity
AURUGA1_00838	COG0133	tryptophan synthase activity
AURUGA1_00839	COG0134	indole-3-glycerol-phosphate synthase activity
AURUGA1_00844	COG0107	imidazoleglycerol-phosphate synthase activity
AURUGA1_00845	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AURUGA1_00846	COG0140	phosphoribosyl-ATP diphosphatase activity
AURUGA1_00849	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AURUGA1_00851	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AURUGA1_00853	COG1758	RNA polymerase activity
AURUGA1_00854	COG0194	GDP metabolic process
AURUGA1_00855	COG0284	orotidine-5'-phosphate decarboxylase activity
AURUGA1_00856	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AURUGA1_00857	COG0505	Belongs to the CarA family
AURUGA1_00859	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AURUGA1_00860	COG0540	Belongs to the ATCase OTCase family
AURUGA1_00861	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AURUGA1_00862	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AURUGA1_00863	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AURUGA1_00864	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AURUGA1_00865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AURUGA1_00867	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AURUGA1_00868	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AURUGA1_00870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AURUGA1_00871	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AURUGA1_00873	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AURUGA1_00878	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AURUGA1_00879	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AURUGA1_00880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AURUGA1_00882	COG2255	four-way junction helicase activity
AURUGA1_00883	COG0632	four-way junction helicase activity
AURUGA1_00884	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AURUGA1_00885	COG0217	transcriptional regulatory protein
AURUGA1_00886	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AURUGA1_00887	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AURUGA1_00889	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AURUGA1_00901	COG0183	Belongs to the thiolase family
AURUGA1_00902	COG1250	3-hydroxyacyl-CoA dehydrogenase
AURUGA1_00902	COG1024	Enoyl-CoA hydratase
AURUGA1_00903	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AURUGA1_00904	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AURUGA1_00907	COG0756	dUTP diphosphatase activity
AURUGA1_00912	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AURUGA1_00913	COG0187	DNA topoisomerase II activity
AURUGA1_00915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AURUGA1_00917	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AURUGA1_00918	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AURUGA1_00919	COG0508	dehydrogenase complex catalyzes the overall conversion of
AURUGA1_00921	COG0321	lipoyl(octanoyl) transferase activity
AURUGA1_00922	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AURUGA1_00925	COG0174	glutamine synthetase
AURUGA1_00926	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AURUGA1_00928	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AURUGA1_00928	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AURUGA1_00929	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AURUGA1_00933	COG0406	alpha-ribazole phosphatase activity
AURUGA1_00933	COG0328	RNA-DNA hybrid ribonuclease activity
AURUGA1_00935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AURUGA1_00939	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AURUGA1_00942	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AURUGA1_00943	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AURUGA1_00949	COG2197	response regulator
AURUGA1_00951	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AURUGA1_00953	COG0438	transferase activity, transferring glycosyl groups
AURUGA1_00955	COG0242	peptide deformylase activity
AURUGA1_00960	COG0358	DNA primase activity
AURUGA1_00965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AURUGA1_00966	COG1381	Involved in DNA repair and RecF pathway recombination
AURUGA1_00967	COG2860	membrane
AURUGA1_00969	COG0488	(ABC) transporter
AURUGA1_00972	COG2151	metal-sulfur cluster biosynthetic enzyme
AURUGA1_00973	COG0396	ATPase activity
AURUGA1_00974	COG2146	nitrite reductase [NAD(P)H] activity
AURUGA1_00977	COG1612	heme a metabolic process
AURUGA1_00978	COG0109	protoheme IX farnesyltransferase activity
AURUGA1_00981	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AURUGA1_00985	COG0363	glucosamine-6-phosphate deaminase activity
AURUGA1_00987	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AURUGA1_00988	COG0149	triose-phosphate isomerase activity
AURUGA1_00989	COG0126	phosphoglycerate kinase activity
AURUGA1_00990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AURUGA1_00992	COG1481	regulation of sporulation
AURUGA1_00993	COG1660	Displays ATPase and GTPase activities
AURUGA1_00995	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AURUGA1_00996	COG3599	regulation of cell shape
AURUGA1_00998	COG1799	cell septum assembly
AURUGA1_00999	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AURUGA1_01000	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AURUGA1_01002	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AURUGA1_01003	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AURUGA1_01005	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AURUGA1_01006	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AURUGA1_01008	COG0768	penicillin binding
AURUGA1_01010	COG0275	rRNA processing
AURUGA1_01011	COG2001	Belongs to the MraZ family
AURUGA1_01016	COG0515	serine threonine protein kinase
AURUGA1_01016	COG2815	serine threonine protein kinase
AURUGA1_01017	COG0495	leucyl-tRNA aminoacylation
AURUGA1_01022	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AURUGA1_01025	COG2813	Specifically methylates the guanine in position
AURUGA1_01027	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AURUGA1_01028	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AURUGA1_01029	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AURUGA1_01032	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AURUGA1_01034	COG1396	sequence-specific DNA binding
AURUGA1_01035	COG1058	Belongs to the CinA family
AURUGA1_01035	COG1546	Belongs to the CinA family
AURUGA1_01037	COG1674	ftsk spoiiie
AURUGA1_01038	COG0366	Alpha amylase catalytic
AURUGA1_01043	COG1609	Transcriptional regulator
AURUGA1_01044	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AURUGA1_01045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AURUGA1_01046	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AURUGA1_01049	COG1090	epimerase
AURUGA1_01052	COG4974	Belongs to the 'phage' integrase family
AURUGA1_01055	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AURUGA1_01057	COG0335	large ribosomal subunit rRNA binding
AURUGA1_01058	COG0336	Belongs to the RNA methyltransferase TrmD family
AURUGA1_01059	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AURUGA1_01060	COG1837	Belongs to the UPF0109 family
AURUGA1_01061	COG0228	four-way junction DNA binding
AURUGA1_01062	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AURUGA1_01064	COG1832	CoA-binding protein
AURUGA1_01067	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AURUGA1_01068	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AURUGA1_01070	COG1116	anion transmembrane transporter activity
AURUGA1_01072	COG0552	protein localization to endoplasmic reticulum
AURUGA1_01073	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AURUGA1_01075	COG0742	ribosomal rna small subunit methyltransferase
AURUGA1_01078	COG1181	Belongs to the D-alanine--D-alanine ligase family
AURUGA1_01079	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AURUGA1_01081	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AURUGA1_01082	COG0066	3-isopropylmalate dehydratase activity
AURUGA1_01083	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AURUGA1_01084	COG0861	Integral membrane protein TerC family
AURUGA1_01089	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AURUGA1_01090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AURUGA1_01091	COG0473	3-isopropylmalate dehydrogenase activity
AURUGA1_01095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AURUGA1_01096	COG0440	acetolactate synthase activity
AURUGA1_01098	COG0129	dihydroxy-acid dehydratase activity
AURUGA1_01099	COG1082	Xylose isomerase domain protein TIM barrel
AURUGA1_01100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AURUGA1_01101	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AURUGA1_01103	COG1615	UPF0182 protein
AURUGA1_01104	COG3480	Lon protease (S16) C-terminal proteolytic domain
AURUGA1_01110	COG0210	DNA helicase
AURUGA1_01116	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AURUGA1_01120	COG2252	PERMEase
AURUGA1_01123	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AURUGA1_01128	COG0702	epimerase
AURUGA1_01133	COG2986	histidine ammonia-lyase
AURUGA1_01134	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AURUGA1_01135	COG1228	amidohydrolase
AURUGA1_01138	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AURUGA1_01140	COG0483	inositol monophosphate 1-phosphatase activity
AURUGA1_01143	COG0386	Belongs to the glutathione peroxidase family
AURUGA1_01145	COG0463	Glycosyl transferase, family 2
AURUGA1_01149	COG1247	-acetyltransferase
AURUGA1_01151	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AURUGA1_01153	COG2884	Cell division ATP-binding protein ftsE
AURUGA1_01157	COG3485	protocatechuate 3,4-dioxygenase
AURUGA1_01160	COG0433	COG0433 Predicted ATPase
AURUGA1_01160	COG1674	ftsk spoiiie
AURUGA1_01164	COG0714	Associated with various cellular activities
AURUGA1_01167	COG0631	protein serine/threonine phosphatase activity
AURUGA1_01170	COG1414	Transcriptional regulator
AURUGA1_01172	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AURUGA1_01173	COG0571	ribonuclease III activity
AURUGA1_01174	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AURUGA1_01178	COG0586	Pfam SNARE associated Golgi protein
AURUGA1_01179	COG0384	phenazine biosynthesis protein PhzF
AURUGA1_01188	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AURUGA1_01189	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AURUGA1_01190	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AURUGA1_01191	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AURUGA1_01192	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AURUGA1_01193	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AURUGA1_01194	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AURUGA1_01195	COG0356	it plays a direct role in the translocation of protons across the membrane
AURUGA1_01197	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AURUGA1_01198	COG0009	L-threonylcarbamoyladenylate synthase
AURUGA1_01200	COG2890	protein-(glutamine-N5) methyltransferase activity
AURUGA1_01202	COG1045	serine acetyltransferase
AURUGA1_01205	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AURUGA1_01206	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AURUGA1_01209	COG0083	homoserine kinase activity
AURUGA1_01211	COG0460	homoserine dehydrogenase
AURUGA1_01214	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AURUGA1_01227	COG1216	Glycosyl transferase, family 2
AURUGA1_01236	COG0018	arginyl-trna synthetase
AURUGA1_01237	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AURUGA1_01240	COG0567	Dehydrogenase, E1 component
AURUGA1_01240	COG0508	dehydrogenase complex catalyzes the overall conversion of
AURUGA1_01242	COG1595	DNA-templated transcription, initiation
AURUGA1_01243	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AURUGA1_01244	COG1162	GTPase activity
AURUGA1_01245	COG1088	dTDP-glucose 4,6-dehydratase activity
AURUGA1_01253	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AURUGA1_01254	COG3594	Acyltransferase
AURUGA1_01257	COG1250	3-hydroxyacyl-CoA dehydrogenase
AURUGA1_01257	COG1024	Enoyl-CoA hydratase
AURUGA1_01258	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AURUGA1_01273	COG0653	protein targeting
AURUGA1_01275	COG1040	competence protein
AURUGA1_01276	COG5401	PFAM Sporulation and spore germination
AURUGA1_01277	COG5002	protein histidine kinase activity
AURUGA1_01277	COG5000	phosphorelay sensor kinase activity
AURUGA1_01279	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AURUGA1_01288	COG1316	TRANSCRIPTIONal
AURUGA1_01292	COG0463	Glycosyl transferase, family 2
AURUGA1_01295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AURUGA1_01298	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AURUGA1_01299	COG0424	maF-like protein
AURUGA1_01300	COG4770	biotin carboxylase activity
AURUGA1_01303	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AURUGA1_01304	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AURUGA1_01304	COG0662	Cupin 2, conserved barrel domain protein
AURUGA1_01305	COG2009	succinate dehydrogenase
AURUGA1_01307	COG1053	succinate dehydrogenase
AURUGA1_01308	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AURUGA1_01309	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AURUGA1_01310	COG1349	DNA-binding transcription factor activity
AURUGA1_01312	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AURUGA1_01312	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AURUGA1_01312	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AURUGA1_01313	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AURUGA1_01313	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AURUGA1_01317	COG0708	Exodeoxyribonuclease III
AURUGA1_01318	COG0180	Tryptophanyl-tRNA synthetase
AURUGA1_01321	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AURUGA1_01321	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AURUGA1_01322	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AURUGA1_01324	COG1132	(ABC) transporter
AURUGA1_01331	COG0501	Belongs to the peptidase M48B family
AURUGA1_01333	COG0470	DNA polymerase III
AURUGA1_01334	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AURUGA1_01335	COG1754	DNA topoisomerase type I activity
AURUGA1_01335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AURUGA1_01341	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AURUGA1_01344	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AURUGA1_01346	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AURUGA1_01347	COG1435	thymidine kinase activity
AURUGA1_01351	COG0579	oxidoreductase
AURUGA1_01354	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AURUGA1_01363	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AURUGA1_01365	COG1012	belongs to the aldehyde dehydrogenase family
AURUGA1_01366	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AURUGA1_01368	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AURUGA1_01375	COG0137	argininosuccinate synthase activity
AURUGA1_01376	COG0673	inositol 2-dehydrogenase activity
AURUGA1_01377	COG1940	carbohydrate kinase activity
AURUGA1_01378	COG2115	Belongs to the xylose isomerase family
AURUGA1_01379	COG1070	Carbohydrate kinase
AURUGA1_01380	COG4213	ABC transporter substrate-binding protein
AURUGA1_01382	COG4214	carbohydrate transport
AURUGA1_01385	COG0222	ribosome binding
AURUGA1_01386	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AURUGA1_01387	COG1105	Belongs to the carbohydrate kinase PfkB family
AURUGA1_01388	COG2205	protein histidine kinase activity
AURUGA1_01389	COG0745	RESPONSE REGULATOR receiver
AURUGA1_01392	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AURUGA1_01393	COG0081	regulation of translation
AURUGA1_01394	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AURUGA1_01396	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AURUGA1_01398	COG0436	Aminotransferase
AURUGA1_01400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AURUGA1_01402	COG2030	dehydratase
AURUGA1_01403	COG0076	glutamate decarboxylase activity
AURUGA1_01404	COG2957	Belongs to the agmatine deiminase family
AURUGA1_01406	COG1064	alcohol dehydrogenase
AURUGA1_01410	COG3885	ferrous iron binding
AURUGA1_01410	COG2078	PFAM AMMECR1 domain protein
AURUGA1_01412	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AURUGA1_01413	COG1846	Transcriptional regulator
AURUGA1_01416	COG0174	glutamine synthetase
AURUGA1_01419	COG1012	belongs to the aldehyde dehydrogenase family
AURUGA1_01422	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AURUGA1_01422	COG0519	Catalyzes the synthesis of GMP from XMP
AURUGA1_01425	COG1802	Transcriptional regulator
AURUGA1_01427	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AURUGA1_01433	COG1834	amidinotransferase
AURUGA1_01434	COG0138	bifunctional purine biosynthesis protein purh
AURUGA1_01439	COG0045	succinate-CoA ligase (ADP-forming) activity
AURUGA1_01442	COG0584	glycerophosphoryl diester phosphodiesterase
AURUGA1_01447	COG0387	Pfam Sodium calcium exchanger
AURUGA1_01451	COG0366	Alpha amylase catalytic
AURUGA1_01456	COG2838	Isocitrate dehydrogenase
AURUGA1_01457	COG2409	Drug exporters of the RND superfamily
AURUGA1_01461	COG1666	GTP binding
AURUGA1_01462	COG2272	Belongs to the type-B carboxylesterase lipase family
AURUGA1_01464	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AURUGA1_01465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AURUGA1_01466	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AURUGA1_01472	COG0745	RESPONSE REGULATOR receiver
AURUGA1_01474	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AURUGA1_01475	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AURUGA1_01477	COG0151	Belongs to the GarS family
AURUGA1_01478	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AURUGA1_01479	COG2364	Membrane
AURUGA1_01484	COG0438	transferase activity, transferring glycosyl groups
AURUGA1_01492	COG3483	tryptophan 2,3-dioxygenase activity
AURUGA1_01495	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AURUGA1_01496	COG0047	phosphoribosylformylglycinamidine synthase activity
AURUGA1_01498	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AURUGA1_01499	COG0656	L-ascorbic acid biosynthetic process
AURUGA1_01502	COG1605	Chorismate mutase
AURUGA1_01502	COG0287	Prephenate dehydrogenase
AURUGA1_01503	COG0697	spore germination
AURUGA1_01506	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AURUGA1_01509	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AURUGA1_01510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AURUGA1_01512	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AURUGA1_01513	COG0531	amino acid
AURUGA1_01515	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AURUGA1_01517	COG0730	response to heat
AURUGA1_01518	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AURUGA1_01519	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AURUGA1_01522	COG0142	geranyltranstransferase activity
AURUGA1_01523	COG2226	methyltransferase
AURUGA1_01524	COG1169	isochorismate synthase
AURUGA1_01525	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AURUGA1_01530	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AURUGA1_01531	COG4948	Mandelate Racemase Muconate Lactonizing
AURUGA1_01532	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AURUGA1_01533	COG1333	cytochrome c biogenesis protein
AURUGA1_01534	COG0785	Cytochrome C biogenesis protein
AURUGA1_01535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AURUGA1_01536	COG0406	alpha-ribazole phosphatase activity
AURUGA1_01537	COG0017	Asparaginyl-tRNA synthetase
AURUGA1_01538	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
AURUGA1_01543	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AURUGA1_01544	COG0569	domain protein
AURUGA1_01545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AURUGA1_01547	COG0590	tRNA wobble adenosine to inosine editing
AURUGA1_01548	COG0745	RESPONSE REGULATOR receiver
AURUGA1_01549	COG0415	Belongs to the DNA photolyase family
AURUGA1_01551	COG1305	Transglutaminase-like
AURUGA1_01553	COG2308	Evidence 4 Homologs of previously reported genes of
AURUGA1_01558	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AURUGA1_01561	COG1231	oxidoreductase activity
AURUGA1_01562	COG0009	L-threonylcarbamoyladenylate synthase
AURUGA1_01569	COG1028	Short-chain dehydrogenase reductase Sdr
AURUGA1_01574	COG1028	Short-chain dehydrogenase reductase Sdr
AURUGA1_01575	COG0542	response to heat
AURUGA1_01577	COG2813	Specifically methylates the guanine in position
AURUGA1_01580	COG0789	Transcriptional regulator
AURUGA1_01581	COG0484	heat shock protein binding
AURUGA1_01582	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AURUGA1_01583	COG0443	Heat shock 70 kDa protein
AURUGA1_01585	COG1902	pentaerythritol trinitrate reductase activity
AURUGA1_01592	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AURUGA1_01593	COG2197	response regulator
AURUGA1_01595	COG0717	Belongs to the dCTP deaminase family
AURUGA1_01598	COG0305	Participates in initiation and elongation during chromosome replication
AURUGA1_01599	COG0359	binds to the 23S rRNA
AURUGA1_01600	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AURUGA1_01602	COG0360	Binds together with S18 to 16S ribosomal RNA
AURUGA1_01603	COG0617	tRNA 3'-terminal CCA addition
AURUGA1_01607	COG3118	belongs to the thioredoxin family
AURUGA1_01608	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AURUGA1_01611	COG1192	Involved in chromosome partitioning
AURUGA1_01612	COG0357	Ribosomal RNA small subunit methyltransferase G
AURUGA1_01614	COG0706	membrane insertase activity
AURUGA1_01615	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AURUGA1_01617	COG0230	Belongs to the bacterial ribosomal protein bL34 family