locus-tag	class	description
FF125_00010	COG1349	DNA-binding transcription factor activity
FF125_00015	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FF125_00025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FF125_00035	COG4771	TonB-dependent receptor
FF125_00060	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_00080	COG2267	carboxylic ester hydrolase activity
FF125_00130	COG3530	Putative quorum-sensing-regulated virulence factor
FF125_00180	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FF125_00190	COG1131	(ABC) transporter
FF125_00200	COG4935	Belongs to the peptidase S8 family
FF125_00200	COG2234	aminopeptidase activity
FF125_00205	COG1132	(ABC) transporter
FF125_00220	COG4206	TonB-dependent receptor
FF125_00220	COG1629	transport
FF125_00225	COG4771	TonB-dependent receptor
FF125_00245	COG3119	arylsulfatase activity
FF125_00255	COG1472	Belongs to the glycosyl hydrolase 3 family
FF125_00260	COG3119	arylsulfatase activity
FF125_00270	COG3119	arylsulfatase activity
FF125_00275	COG1472	Belongs to the glycosyl hydrolase 3 family
FF125_00285	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FF125_00290	COG3119	arylsulfatase activity
FF125_00295	COG3537	Alpha-1,2-mannosidase
FF125_00310	COG1472	Belongs to the glycosyl hydrolase 3 family
FF125_00325	COG0702	epimerase
FF125_00330	COG4771	TonB-dependent receptor
FF125_00355	COG3119	arylsulfatase activity
FF125_00360	COG0077	Prephenate dehydratase
FF125_00360	COG1605	Chorismate mutase
FF125_00365	COG0436	Aminotransferase
FF125_00370	COG0287	Prephenate dehydrogenase
FF125_00375	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FF125_00390	COG1595	DNA-templated transcription, initiation
FF125_00405	COG1652	LysM domain
FF125_00415	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FF125_00430	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FF125_00435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FF125_00445	COG0626	cystathionine gamma-synthase activity
FF125_00480	COG1435	thymidine kinase activity
FF125_00485	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FF125_00490	COG1970	mechanosensitive ion channel activity
FF125_00510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FF125_00515	COG0194	GDP metabolic process
FF125_00555	COG0488	(ABC) transporter
FF125_00570	COG0745	RESPONSE REGULATOR receiver
FF125_00575	COG5002	protein histidine kinase activity
FF125_00580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FF125_00600	COG0438	transferase activity, transferring glycosyl groups
FF125_00610	COG1216	Glycosyl transferase, family 2
FF125_00620	COG1215	transferase activity, transferring glycosyl groups
FF125_00645	COG0793	Belongs to the peptidase S41A family
FF125_00650	COG0594	ribonuclease P activity
FF125_00670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FF125_00675	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FF125_00685	COG1519	Transferase
FF125_00685	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FF125_00705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FF125_00710	COG0303	'Molybdopterin
FF125_00715	COG0315	cyclic pyranopterin monophosphate synthase activity
FF125_00720	COG0746	molybdenum cofactor guanylyltransferase activity
FF125_00730	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FF125_00745	COG0314	molybdopterin synthase activity
FF125_00755	COG2814	Major facilitator Superfamily
FF125_00765	COG0659	secondary active sulfate transmembrane transporter activity
FF125_00775	COG2378	regulation of single-species biofilm formation
FF125_00780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FF125_00780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FF125_00810	COG0708	Exodeoxyribonuclease III
FF125_00815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FF125_00820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FF125_00830	COG1774	PSP1 C-terminal conserved region
FF125_00835	COG1196	nuclear chromosome segregation
FF125_00835	COG0741	lytic transglycosylase activity
FF125_00835	COG0739	heme binding
FF125_00840	COG0470	DNA polymerase III
FF125_00845	COG1272	protein, Hemolysin III
FF125_00860	COG0667	Aldo Keto reductase
FF125_00865	COG0126	phosphoglycerate kinase activity
FF125_00875	COG0516	GMP reductase activity
FF125_00875	COG0517	IMP dehydrogenase activity
FF125_00895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FF125_00905	COG4948	Mandelate Racemase Muconate Lactonizing
FF125_00915	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FF125_00915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FF125_00930	COG4771	TonB-dependent receptor
FF125_00950	COG4676	Protein conserved in bacteria
FF125_00955	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FF125_00965	COG2183	response to ionizing radiation
FF125_00980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FF125_00980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FF125_00985	COG1619	proteins homologs of microcin C7 resistance protein MccF
FF125_00990	COG0792	nuclease activity
FF125_01015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FF125_01035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FF125_01035	COG1321	iron dependent repressor
FF125_01050	COG1074	ATP-dependent DNA helicase activity
FF125_01060	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FF125_01060	COG2124	cytochrome p450
FF125_01085	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FF125_01090	COG0714	Associated with various cellular activities
FF125_01110	COG2304	oxidoreductase activity
FF125_01130	COG2226	methyltransferase
FF125_01155	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FF125_01185	COG0469	pyruvate kinase activity
FF125_01195	COG0571	ribonuclease III activity
FF125_01200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FF125_01205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FF125_01210	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FF125_01215	COG0328	RNA-DNA hybrid ribonuclease activity
FF125_01215	COG3341	Caulimovirus viroplasmin
FF125_01220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FF125_01225	COG0842	Transport permease protein
FF125_01230	COG0842	Transport permease protein
FF125_01235	COG1131	(ABC) transporter
FF125_01240	COG1131	(ABC) transporter
FF125_01250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FF125_01270	COG0719	Fe-S assembly protein
FF125_01275	COG0396	ATPase activity
FF125_01285	COG0719	Fe-S assembly protein
FF125_01290	COG0316	Belongs to the HesB IscA family
FF125_01355	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FF125_01370	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FF125_01375	COG0322	excinuclease ABC activity
FF125_01385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FF125_01400	COG1309	transcriptional regulator
FF125_01405	COG0142	geranyltranstransferase activity
FF125_01425	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FF125_01435	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FF125_01440	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FF125_01445	COG0511	ligase activity, forming carbon-carbon bonds
FF125_01450	COG0439	Biotin carboxylase
FF125_01455	COG1522	sequence-specific DNA binding
FF125_01460	COG2738	Putative neutral zinc metallopeptidase
FF125_01465	COG0252	asparaginase activity
FF125_01475	COG0811	peptide transport
FF125_01505	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FF125_01515	COG0017	Asparaginyl-tRNA synthetase
FF125_01535	COG0233	cytoplasmic translational termination
FF125_01540	COG0528	UMP kinase activity
FF125_01545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FF125_01550	COG0052	Belongs to the universal ribosomal protein uS2 family
FF125_01555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FF125_01560	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FF125_01590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FF125_01590	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FF125_01595	COG1446	asparaginase
FF125_01605	COG3142	Participates in the control of copper homeostasis
FF125_01610	COG3118	belongs to the thioredoxin family
FF125_01720	COG0589	response to stress
FF125_01725	COG0589	response to stress
FF125_01730	COG0779	Required for maturation of 30S ribosomal subunits
FF125_01735	COG2251	uridine kinase activity
FF125_01735	COG0195	Participates in both transcription termination and antitermination
FF125_01740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FF125_01750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FF125_01770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FF125_01780	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FF125_01785	COG0069	glutamate synthase activity
FF125_01790	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FF125_01800	COG0460	homoserine dehydrogenase
FF125_01800	COG0527	aspartate kinase activity
FF125_01810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FF125_01815	COG0527	aspartate kinase activity
FF125_01825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FF125_01835	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FF125_01845	COG2197	response regulator
FF125_01850	COG4585	Histidine kinase
FF125_01880	COG1917	Cupin 2, conserved barrel domain protein
FF125_01880	COG2207	Transcriptional regulator
FF125_01890	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FF125_01900	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FF125_01910	COG3852	Histidine kinase
FF125_01930	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FF125_01945	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FF125_01960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FF125_01985	COG0363	glucosamine-6-phosphate deaminase activity
FF125_01995	COG1609	Transcriptional regulator
FF125_02000	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
FF125_02005	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_02010	COG4677	pectinesterase activity
FF125_02015	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FF125_02025	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FF125_02030	COG1609	Transcriptional regulator
FF125_02040	COG0363	glucosamine-6-phosphate deaminase activity
FF125_02055	COG0702	epimerase
FF125_02060	COG4771	TonB-dependent receptor
FF125_02075	COG1629	transport
FF125_02115	COG0156	8-amino-7-oxononanoate synthase activity
FF125_02160	COG4974	Belongs to the 'phage' integrase family
FF125_02250	COG4335	DNA alkylation repair
FF125_02255	COG2207	Transcriptional regulator
FF125_02265	COG0456	acetyltransferase
FF125_02290	COG2205	protein histidine kinase activity
FF125_02290	COG3292	Two component regulator propeller
FF125_02290	COG0745	RESPONSE REGULATOR receiver
FF125_02310	COG3119	arylsulfatase activity
FF125_02320	COG3250	beta-galactosidase activity
FF125_02385	COG3620	sequence-specific DNA binding
FF125_02410	COG1733	regulation of RNA biosynthetic process
FF125_02450	COG3547	Transposase (IS116 IS110 IS902 family)
FF125_02465	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_02480	COG2249	NAD(P)H dehydrogenase (quinone) activity
FF125_02505	COG0492	ferredoxin-NADP+ reductase activity
FF125_02525	COG0024	Methionine aminopeptidase
FF125_02550	COG2814	Major facilitator Superfamily
FF125_02570	COG1673	EVE domain
FF125_02575	COG1846	Transcriptional regulator
FF125_02600	COG0702	epimerase
FF125_02605	COG1917	Cupin 2, conserved barrel domain protein
FF125_02605	COG4977	sequence-specific DNA binding
FF125_02610	COG2378	regulation of single-species biofilm formation
FF125_02705	COG4771	TonB-dependent receptor
FF125_02740	COG3537	Alpha-1,2-mannosidase
FF125_02745	COG3537	Alpha-1,2-mannosidase
FF125_02755	COG3537	Alpha-1,2-mannosidase
FF125_02760	COG1785	Belongs to the alkaline phosphatase family
FF125_02780	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FF125_02785	COG4771	TonB-dependent receptor
FF125_02790	COG0738	Major facilitator superfamily
FF125_02800	COG2205	protein histidine kinase activity
FF125_02800	COG3292	Two component regulator propeller
FF125_02800	COG0745	RESPONSE REGULATOR receiver
FF125_02800	COG2205	protein histidine kinase activity
FF125_02800	COG0745	RESPONSE REGULATOR receiver
FF125_02800	COG3292	Two component regulator propeller
FF125_02810	COG3250	beta-galactosidase activity
FF125_02825	COG3940	Belongs to the glycosyl hydrolase 43 family
FF125_02840	COG4771	TonB-dependent receptor
FF125_02875	COG1085	galactose-1-phosphate uridylyltransferase
FF125_02880	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FF125_02890	COG0629	single-stranded DNA binding
FF125_02895	COG2003	Belongs to the UPF0758 family
FF125_02915	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_02925	COG3537	Alpha-1,2-mannosidase
FF125_02945	COG0702	epimerase
FF125_02950	COG1629	transport
FF125_02950	COG4206	TonB-dependent receptor
FF125_02980	COG0702	epimerase
FF125_02980	COG0702	epimerase
FF125_02985	COG1629	transport
FF125_02985	COG4206	TonB-dependent receptor
FF125_03010	COG0109	protoheme IX farnesyltransferase activity
FF125_03015	COG1845	cytochrome c oxidase, subunit III
FF125_03035	COG1999	signal sequence binding
FF125_03040	COG2322	membrane
FF125_03055	COG1214	PFAM Peptidase M22, glycoprotease
FF125_03060	COG0668	transmembrane transport
FF125_03070	COG1331	Highly conserved protein containing a thioredoxin domain
FF125_03080	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FF125_03085	COG3291	Pkd domain containing protein
FF125_03105	COG2972	Histidine kinase
FF125_03105	COG0745	RESPONSE REGULATOR receiver
FF125_03110	COG3279	Response regulator of the LytR AlgR family
FF125_03115	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FF125_03130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FF125_03150	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FF125_03160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FF125_03170	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FF125_03180	COG1950	PFAM Membrane protein of
FF125_03185	COG0544	peptidyl-prolyl cis-trans isomerase activity
FF125_03200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FF125_03205	COG0358	DNA primase activity
FF125_03210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FF125_03225	COG1428	Deoxynucleoside kinase
FF125_03230	COG0616	signal peptide processing
FF125_03260	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FF125_03285	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
FF125_03290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
FF125_03300	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FF125_03310	COG0022	dehydrogenase e1 component
FF125_03310	COG0508	dehydrogenase complex catalyzes the overall conversion of
FF125_03315	COG1629	transport
FF125_03320	COG0457	Tetratricopeptide repeat
FF125_03325	COG3292	Two component regulator propeller
FF125_03325	COG2205	protein histidine kinase activity
FF125_03325	COG0745	RESPONSE REGULATOR receiver
FF125_03335	COG4771	TonB-dependent receptor
FF125_03340	COG0702	epimerase
FF125_03385	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FF125_03410	COG0509	glycine decarboxylation via glycine cleavage system
FF125_03420	COG0632	four-way junction helicase activity
FF125_03430	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FF125_03445	COG2255	four-way junction helicase activity
FF125_03465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FF125_03465	COG3743	rRNA binding
FF125_03490	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FF125_03500	COG0129	dihydroxy-acid dehydratase activity
FF125_03505	COG0028	Belongs to the TPP enzyme family
FF125_03510	COG0440	acetolactate synthase activity
FF125_03515	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FF125_03520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FF125_03525	COG1012	belongs to the aldehyde dehydrogenase family
FF125_03535	COG1047	Peptidyl-prolyl cis-trans
FF125_03575	COG0545	Peptidyl-prolyl cis-trans isomerase
FF125_03665	COG1136	(ABC) transporter
FF125_03665	COG0577	efflux transmembrane transporter activity
FF125_03670	COG1136	(ABC) transporter
FF125_03670	COG0577	efflux transmembrane transporter activity
FF125_03680	COG0473	3-isopropylmalate dehydrogenase activity
FF125_03685	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FF125_03695	COG0564	pseudouridine synthase activity
FF125_03700	COG0218	Necessary for normal cell division and for the maintenance of normal septation
FF125_03705	COG0596	Alpha beta hydrolase
FF125_03710	COG2001	Belongs to the MraZ family
FF125_03715	COG0275	rRNA processing
FF125_03730	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FF125_03735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FF125_03740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FF125_03745	COG0772	Belongs to the SEDS family
FF125_03750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FF125_03755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FF125_03770	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FF125_03775	COG1610	YqeY-like protein
FF125_03785	COG3119	arylsulfatase activity
FF125_03790	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FF125_03795	COG1085	galactose-1-phosphate uridylyltransferase
FF125_03800	COG2207	Transcriptional regulator
FF125_03805	COG4771	TonB-dependent receptor
FF125_03815	COG2271	Major facilitator Superfamily
FF125_03825	COG3119	arylsulfatase activity
FF125_03830	COG3119	arylsulfatase activity
FF125_03845	COG1874	Beta-galactosidase
FF125_03855	COG2814	Major facilitator Superfamily
FF125_03865	COG3119	arylsulfatase activity
FF125_03870	COG3119	arylsulfatase activity
FF125_03875	COG4948	Mandelate Racemase Muconate Lactonizing
FF125_03880	COG1012	belongs to the aldehyde dehydrogenase family
FF125_03890	COG1472	Belongs to the glycosyl hydrolase 3 family
FF125_03895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FF125_03900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FF125_03910	COG3292	Two component regulator propeller
FF125_03910	COG2205	protein histidine kinase activity
FF125_03910	COG0745	RESPONSE REGULATOR receiver
FF125_03915	COG4771	TonB-dependent receptor
FF125_03935	COG3661	Belongs to the glycosyl hydrolase 67 family
FF125_03990	COG2211	Major facilitator Superfamily
FF125_04000	COG1472	Belongs to the glycosyl hydrolase 3 family
FF125_04005	COG3459	Glycosyltransferase 36 associated
FF125_04010	COG2211	Major facilitator Superfamily
FF125_04015	COG3291	Pkd domain containing protein
FF125_04020	COG4124	Belongs to the glycosyl hydrolase 26 family
FF125_04025	COG1501	Belongs to the glycosyl hydrolase 31 family
FF125_04040	COG3345	alpha-galactosidase
FF125_04050	COG0561	phosphatase activity
FF125_04055	COG4771	TonB-dependent receptor
FF125_04075	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
FF125_04080	COG2942	2-epimerase
FF125_04090	COG2273	Hydrolase Family 16
FF125_04090	COG5297	Belongs to the glycosyl hydrolase family 6
FF125_04105	COG2723	6-phospho-beta-galactosidase activity
FF125_04135	COG4952	isomerase
FF125_04140	COG3347	Dehydrogenase
FF125_04140	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_04160	COG0667	Aldo Keto reductase
FF125_04185	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FF125_04190	COG4771	TonB-dependent receptor
FF125_04200	COG4771	TonB-dependent receptor
FF125_04220	COG1472	Belongs to the glycosyl hydrolase 3 family
FF125_04250	COG2160	L-arabinose isomerase activity
FF125_04255	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FF125_04265	COG1070	Carbohydrate kinase
FF125_04270	COG2115	Belongs to the xylose isomerase family
FF125_04275	COG0477	Major facilitator Superfamily
FF125_04275	COG2814	Major facilitator Superfamily
FF125_04280	COG0517	IMP dehydrogenase activity
FF125_04305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FF125_04310	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FF125_04315	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FF125_04320	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FF125_04325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FF125_04330	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FF125_04335	COG0356	it plays a direct role in the translocation of protons across the membrane
FF125_04375	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FF125_04385	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FF125_04390	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FF125_04405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FF125_04415	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FF125_04420	COG2363	Small membrane protein
FF125_04430	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
FF125_04435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FF125_04440	COG0228	four-way junction DNA binding
FF125_04445	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FF125_04470	COG1278	Cold shock
FF125_04480	COG1629	transport
FF125_04490	COG1132	(ABC) transporter
FF125_04560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FF125_04570	COG1757	Na H antiporter
FF125_04580	COG1162	GTPase activity
FF125_04595	COG0519	Catalyzes the synthesis of GMP from XMP
FF125_04610	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FF125_04625	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_04635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FF125_04640	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FF125_04645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FF125_04660	COG3842	ATPase activity
FF125_04670	COG1505	serine-type exopeptidase activity
FF125_04740	COG3408	Glycogen debranching enzyme
FF125_04775	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FF125_04785	COG0826	peptidase U32
FF125_04805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FF125_04820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FF125_04820	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FF125_04835	COG0513	Belongs to the DEAD box helicase family
FF125_04840	COG1595	DNA-templated transcription, initiation
FF125_04895	COG1785	Belongs to the alkaline phosphatase family
FF125_04910	COG2885	chlorophyll binding
FF125_04920	COG0567	Dehydrogenase, E1 component
FF125_04925	COG0508	dehydrogenase complex catalyzes the overall conversion of
FF125_04950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FF125_04965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FF125_04990	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FF125_04995	COG0459	protein refolding
FF125_05050	COG0138	bifunctional purine biosynthesis protein purh
FF125_05055	COG1077	Cell shape determining protein MreB Mrl
FF125_05070	COG0768	penicillin binding
FF125_05075	COG0772	Belongs to the SEDS family
FF125_05085	COG0268	Binds directly to 16S ribosomal RNA
FF125_05095	COG0442	prolyl-tRNA aminoacylation
FF125_05110	COG4771	TonB-dependent receptor
FF125_05120	COG3876	Protein conserved in bacteria
FF125_05130	COG0488	(ABC) transporter
FF125_05135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FF125_05140	COG0439	Biotin carboxylase
FF125_05145	COG0511	ligase activity, forming carbon-carbon bonds
FF125_05150	COG2176	DNA-directed DNA polymerase activity
FF125_05160	COG1363	Peptidase, m42
FF125_05175	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
FF125_05180	COG1959	2 iron, 2 sulfur cluster binding
FF125_05185	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FF125_05190	COG1770	oligopeptidase
FF125_05215	COG0156	8-amino-7-oxononanoate synthase activity
FF125_05225	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FF125_05235	COG0205	6-phosphofructokinase activity
FF125_05250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FF125_05260	COG0492	ferredoxin-NADP+ reductase activity
FF125_05270	COG0076	glutamate decarboxylase activity
FF125_05310	COG0006	proline dipeptidase activity
FF125_05330	COG1960	acyl-CoA dehydrogenase activity
FF125_05335	COG0183	Belongs to the thiolase family
FF125_05340	COG1024	Enoyl-CoA hydratase
FF125_05340	COG1250	3-hydroxyacyl-CoA dehydrogenase
FF125_05355	COG4152	abc transporter atp-binding protein
FF125_05360	COG1668	transmembrane transport
FF125_05365	COG3264	Mechanosensitive ion channel
FF125_05365	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FF125_05370	COG2204	response regulator
FF125_05375	COG0450	alkyl hydroperoxide reductase
FF125_05390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
FF125_05425	COG2345	Transcriptional regulator
FF125_05540	COG3655	Transcriptional regulator
FF125_05560	COG4974	Belongs to the 'phage' integrase family
FF125_05570	COG2326	polyphosphate kinase activity
FF125_05580	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FF125_05595	COG0788	formyltetrahydrofolate deformylase activity
FF125_05600	COG0179	Fumarylacetoacetate (FAA) hydrolase
FF125_05605	COG2954	triphosphatase activity
FF125_05615	COG1058	Belongs to the CinA family
FF125_05615	COG1546	Belongs to the CinA family
FF125_05620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FF125_05625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FF125_05635	COG0552	protein localization to endoplasmic reticulum
FF125_05645	COG3279	Response regulator of the LytR AlgR family
FF125_05670	COG4585	Histidine kinase
FF125_05680	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FF125_05685	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
FF125_05695	COG4771	TonB-dependent receptor
FF125_05700	COG1506	peptidase
FF125_05700	COG4946	Tricorn protease homolog
FF125_05700	COG0823	Involved in the tonB-independent uptake of proteins
FF125_05705	COG2949	membrane
FF125_05725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FF125_05725	COG0519	Catalyzes the synthesis of GMP from XMP
FF125_05735	COG0784	Response regulator, receiver
FF125_05735	COG2205	protein histidine kinase activity
FF125_05745	COG0745	RESPONSE REGULATOR receiver
FF125_05745	COG2205	protein histidine kinase activity
FF125_05745	COG3292	Two component regulator propeller
FF125_05790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FF125_05795	COG2234	aminopeptidase activity
FF125_05805	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
FF125_05825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FF125_05840	COG3408	Glycogen debranching enzyme
FF125_05840	COG3119	arylsulfatase activity
FF125_05855	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FF125_05855	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FF125_05870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FF125_05895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
FF125_05910	COG0688	phosphatidylethanolamine metabolic process
FF125_05915	COG0575	Belongs to the CDS family
FF125_05925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FF125_05930	COG0799	negative regulation of ribosome biogenesis
FF125_05945	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FF125_05960	COG0659	secondary active sulfate transmembrane transporter activity
FF125_05980	COG0561	phosphatase activity
FF125_05985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FF125_05990	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FF125_05995	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FF125_06000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FF125_06035	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FF125_06040	COG0602	queuosine metabolic process
FF125_06045	COG0433	COG0433 Predicted ATPase
FF125_06070	COG3876	Protein conserved in bacteria
FF125_06080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FF125_06115	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FF125_06125	COG1674	ftsk spoiiie
FF125_06140	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FF125_06140	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FF125_06145	COG1663	tetraacyldisaccharide 4'-kinase activity
FF125_06160	COG4335	DNA alkylation repair
FF125_06175	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
FF125_06195	COG0604	alcohol dehydrogenase
FF125_06200	COG1733	regulation of RNA biosynthetic process
FF125_06205	COG3250	beta-galactosidase activity
FF125_06240	COG1074	ATP-dependent DNA helicase activity
FF125_06245	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FF125_06280	COG3344	reverse transcriptase
FF125_06330	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FF125_06335	COG0436	Aminotransferase
FF125_06340	COG0750	zinc metalloprotease
FF125_06350	COG0525	valine-tRNA ligase activity
FF125_06360	COG0564	pseudouridine synthase activity
FF125_06365	COG1187	pseudouridine synthase activity
FF125_06375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FF125_06395	COG3956	TIGRFAM MazG family protein
FF125_06405	COG0242	peptide deformylase activity
FF125_06410	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FF125_06415	COG2171	N-acyltransferase activity
FF125_06440	COG0009	L-threonylcarbamoyladenylate synthase
FF125_06445	COG0517	IMP dehydrogenase activity
FF125_06445	COG0617	tRNA 3'-terminal CCA addition
FF125_06445	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FF125_06475	COG3153	acetyltransferase
FF125_06475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FF125_06480	COG1960	acyl-CoA dehydrogenase activity
FF125_06495	COG1115	amino acid carrier protein
FF125_06520	COG5549	protein import
FF125_06520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FF125_06530	COG1234	tRNA 3'-trailer cleavage
FF125_06545	COG0540	Belongs to the ATCase OTCase family
FF125_06550	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FF125_06560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
FF125_06570	COG0463	Glycosyl transferase, family 2
FF125_06600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FF125_06615	COG1289	transmembrane transporter activity
FF125_06620	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FF125_06685	COG2852	Protein conserved in bacteria
FF125_06690	COG1181	Belongs to the D-alanine--D-alanine ligase family
FF125_06700	COG0564	pseudouridine synthase activity
FF125_06705	COG2050	protein possibly involved in aromatic compounds catabolism
FF125_06705	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FF125_06770	COG1012	belongs to the aldehyde dehydrogenase family
FF125_06840	COG2076	Multidrug Resistance protein
FF125_06870	COG1228	amidohydrolase
FF125_06880	COG4977	sequence-specific DNA binding
FF125_06880	COG1917	Cupin 2, conserved barrel domain protein
FF125_06885	COG1960	acyl-CoA dehydrogenase activity
FF125_06990	COG0653	protein targeting
FF125_07000	COG2382	esterase
FF125_07020	COG4807	Protein conserved in bacteria
FF125_07045	COG3345	alpha-galactosidase
FF125_07050	COG3022	response to hydroperoxide
FF125_07060	COG2852	Protein conserved in bacteria
FF125_07065	COG1649	PFAM Uncharacterised BCR, COG1649
FF125_07070	COG1760	l-serine dehydratase
FF125_07075	COG0443	Heat shock 70 kDa protein
FF125_07090	COG0534	Mate efflux family protein
FF125_07130	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FF125_07155	COG0335	large ribosomal subunit rRNA binding
FF125_07160	COG0336	Belongs to the RNA methyltransferase TrmD family
FF125_07180	COG2890	protein-(glutamine-N5) methyltransferase activity
FF125_07185	COG0456	acetyltransferase
FF125_07190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FF125_07190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FF125_07195	COG1739	Uncharacterized protein family UPF0029
FF125_07200	COG0824	Thioesterase
FF125_07205	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FF125_07230	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
FF125_07240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FF125_07245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FF125_07255	COG1247	-acetyltransferase
FF125_07265	COG2195	Cleaves the N-terminal amino acid of tripeptides
FF125_07275	COG1132	(ABC) transporter
FF125_07280	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FF125_07285	COG0463	Glycosyl transferase, family 2
FF125_07300	COG0300	oxidoreductase activity
FF125_07305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FF125_07310	COG2706	6-phosphogluconolactonase activity
FF125_07325	COG2234	aminopeptidase activity
FF125_07335	COG1704	LemA family
FF125_07355	COG0556	nucleotide-excision repair
FF125_07365	COG1131	(ABC) transporter
FF125_07375	COG2050	protein possibly involved in aromatic compounds catabolism
FF125_07385	COG1169	isochorismate synthase
FF125_07390	COG0300	oxidoreductase activity
FF125_07395	COG4771	TonB-dependent receptor
FF125_07400	COG2354	Protein conserved in bacteria
FF125_07425	COG3328	transposase activity
FF125_07430	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FF125_07435	COG0482	sulfurtransferase activity
FF125_07460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FF125_07470	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FF125_07495	COG4771	TonB-dependent receptor
FF125_07525	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FF125_07535	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FF125_07545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FF125_07560	COG0105	UTP biosynthetic process
FF125_07565	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FF125_07575	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FF125_07580	COG1595	DNA-templated transcription, initiation
FF125_07595	COG0215	cysteine-tRNA ligase activity
FF125_07600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FF125_07650	COG1678	Uncharacterized ACR, COG1678
FF125_07660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FF125_07665	COG0514	ATP-dependent DNA helicase (RecQ)
FF125_07680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FF125_07695	COG0714	Associated with various cellular activities
FF125_07710	COG2353	YceI-like domain
FF125_07735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FF125_07740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FF125_07745	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FF125_07750	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FF125_07770	COG3328	transposase activity
FF125_07775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FF125_07780	COG2217	Heavy metal translocating P-type atpase
FF125_07795	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FF125_07825	COG0842	Transport permease protein
FF125_07825	COG1131	(ABC) transporter
FF125_07825	COG1716	ATPase activity
FF125_07875	COG0515	serine threonine protein kinase
FF125_07875	COG2815	serine threonine protein kinase
FF125_07880	COG0631	protein serine/threonine phosphatase activity
FF125_07925	COG4974	Belongs to the 'phage' integrase family
FF125_07935	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FF125_07950	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FF125_07965	COG0167	dihydroorotate dehydrogenase activity
FF125_07970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FF125_07970	COG0047	phosphoribosylformylglycinamidine synthase activity
FF125_07990	COG0667	Aldo Keto reductase
FF125_07995	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_08000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FF125_08010	COG0778	Nitroreductase
FF125_08030	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FF125_08035	COG2207	Transcriptional regulator
FF125_08040	COG1024	Enoyl-CoA hydratase
FF125_08060	COG0300	oxidoreductase activity
FF125_08065	COG1917	Cupin 2, conserved barrel domain protein
FF125_08065	COG2169	Transcriptional regulator
FF125_08075	COG2249	NAD(P)H dehydrogenase (quinone) activity
FF125_08105	COG4206	TonB-dependent receptor
FF125_08115	COG0673	inositol 2-dehydrogenase activity
FF125_08125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FF125_08125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FF125_08145	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FF125_08155	COG1803	Methylglyoxal synthase
FF125_08160	COG0251	oxidation-reduction process
FF125_08165	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FF125_08195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FF125_08200	COG2249	NAD(P)H dehydrogenase (quinone) activity
FF125_08330	COG0596	Alpha beta hydrolase
FF125_08335	COG1595	DNA-templated transcription, initiation
FF125_08370	COG1733	regulation of RNA biosynthetic process
FF125_08385	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
FF125_08430	COG3292	Two component regulator propeller
FF125_08430	COG0745	RESPONSE REGULATOR receiver
FF125_08430	COG2205	protein histidine kinase activity
FF125_08440	COG0531	amino acid
FF125_08485	COG3279	Response regulator of the LytR AlgR family
FF125_08490	COG1217	gtp-binding protein TYPA
FF125_08510	COG0424	maF-like protein
FF125_08520	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FF125_08540	COG4771	TonB-dependent receptor
FF125_08560	COG0071	Belongs to the small heat shock protein (HSP20) family
FF125_08575	COG2304	oxidoreductase activity
FF125_08585	COG0542	response to heat
FF125_08625	COG1104	cysteine desulfurase activity
FF125_08645	COG0706	membrane insertase activity
FF125_08650	COG0405	Gamma-glutamyltransferase
FF125_08655	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
FF125_08670	COG0592	DNA-directed DNA polymerase activity
FF125_08700	COG0598	Magnesium transport protein CorA
FF125_08705	COG3119	arylsulfatase activity
FF125_08715	COG2860	membrane
FF125_08745	COG0714	Associated with various cellular activities
FF125_08750	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FF125_08760	COG0107	imidazoleglycerol-phosphate synthase activity
FF125_08765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FF125_08765	COG0140	phosphoribosyl-ATP diphosphatase activity
FF125_08810	COG1607	acyl-coa hydrolase
FF125_08815	COG0668	transmembrane transport
FF125_08835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FF125_08840	COG0066	3-isopropylmalate dehydratase activity
FF125_08865	COG1595	DNA-templated transcription, initiation
FF125_08890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FF125_08905	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FF125_08915	COG1566	PFAM secretion protein HlyD family protein
FF125_08920	COG1136	(ABC) transporter
FF125_08920	COG0577	efflux transmembrane transporter activity
FF125_08925	COG0577	efflux transmembrane transporter activity
FF125_08925	COG1136	(ABC) transporter
FF125_08945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FF125_08950	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
FF125_08960	COG3174	membrane
FF125_09005	COG4716	Myosin-crossreactive antigen
FF125_09025	COG2823	Periplasmic or secreted lipoprotein
FF125_09030	COG1012	belongs to the aldehyde dehydrogenase family
FF125_09035	COG2823	Periplasmic or secreted lipoprotein
FF125_09045	COG1250	3-hydroxyacyl-CoA dehydrogenase
FF125_09045	COG1024	Enoyl-CoA hydratase
FF125_09055	COG0708	Exodeoxyribonuclease III
FF125_09060	COG0531	amino acid
FF125_09080	COG0484	heat shock protein binding
FF125_09120	COG0745	RESPONSE REGULATOR receiver
FF125_09145	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FF125_09145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FF125_09160	COG1342	Belongs to the UPF0251 family
FF125_09165	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FF125_09180	COG2020	methyltransferase activity
FF125_09205	COG1605	Chorismate mutase
FF125_09205	COG0077	Prephenate dehydratase
FF125_09210	COG0745	RESPONSE REGULATOR receiver
FF125_09210	COG3292	Two component regulator propeller
FF125_09210	COG2205	protein histidine kinase activity
FF125_09215	COG1629	transport
FF125_09230	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FF125_09235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FF125_09255	COG0657	acetylesterase activity
FF125_09255	COG2755	lipolytic protein G-D-S-L family
FF125_09265	COG2186	Transcriptional regulator
FF125_09270	COG2731	YhcH YjgK YiaL family protein
FF125_09275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FF125_09280	COG0702	epimerase
FF125_09300	COG4771	TonB-dependent receptor
FF125_09305	COG4974	Belongs to the 'phage' integrase family
FF125_09325	COG1629	transport
FF125_09345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FF125_09360	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FF125_09365	COG2885	chlorophyll binding
FF125_09365	COG3047	cAMP biosynthetic process
FF125_09380	COG0598	Magnesium transport protein CorA
FF125_09460	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FF125_09535	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FF125_09585	COG3177	Filamentation induced by cAMP protein fic
FF125_09650	COG2197	response regulator
FF125_09665	COG2017	converts alpha-aldose to the beta-anomer
FF125_09670	COG1271	oxidase subunit
FF125_09675	COG1294	oxidase, subunit
FF125_09690	COG0446	pyridine nucleotide-disulphide oxidoreductase
FF125_09700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FF125_09735	COG4771	TonB-dependent receptor
FF125_09775	COG3119	arylsulfatase activity
FF125_09790	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FF125_09805	COG4771	TonB-dependent receptor
FF125_09815	COG1629	transport
FF125_09825	COG4771	TonB-dependent receptor
FF125_09840	COG3119	arylsulfatase activity
FF125_09845	COG3119	arylsulfatase activity
FF125_09855	COG4585	Histidine kinase
FF125_09860	COG2197	response regulator
FF125_09910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FF125_09985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
FF125_09985	COG0116	Belongs to the methyltransferase superfamily
FF125_09990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FF125_09995	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FF125_10000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FF125_10025	COG0514	ATP-dependent DNA helicase (RecQ)
FF125_10030	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FF125_10030	COG0517	IMP dehydrogenase activity
FF125_10035	COG0805	protein transport
FF125_10040	COG1137	ATPase activity
FF125_10050	COG0009	L-threonylcarbamoyladenylate synthase
FF125_10070	COG1233	COG1233 Phytoene dehydrogenase and related
FF125_10090	COG0702	epimerase
FF125_10095	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_10115	COG0415	Belongs to the DNA photolyase family
FF125_10130	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FF125_10135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FF125_10145	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FF125_10155	COG0501	Belongs to the peptidase M48B family
FF125_10160	COG0791	NLP P60 protein
FF125_10165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FF125_10175	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FF125_10200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FF125_10205	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FF125_10210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FF125_10225	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FF125_10230	COG2027	D-alanyl-D-alanine carboxypeptidase
FF125_10240	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FF125_10245	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FF125_10265	COG1120	ATPase activity
FF125_10270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FF125_10295	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FF125_10310	COG2089	acid synthase
FF125_10320	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
FF125_10330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FF125_10350	COG4310	Domain of unknown function (DUF2172)
FF125_10370	COG0110	maltose O-acetyltransferase activity
FF125_10395	COG0438	transferase activity, transferring glycosyl groups
FF125_10415	COG2827	Endonuclease containing a URI domain
FF125_10425	COG5434	Belongs to the glycosyl hydrolase 28 family
FF125_10440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FF125_10475	COG0045	succinate-CoA ligase (ADP-forming) activity
FF125_10480	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FF125_10495	COG0686	Belongs to the AlaDH PNT family
FF125_10500	COG0802	atpase or kinase
FF125_10505	COG0217	transcriptional regulatory protein
FF125_10515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FF125_10535	COG0488	(ABC) transporter
FF125_10590	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FF125_10595	COG0745	RESPONSE REGULATOR receiver
FF125_10600	COG5002	protein histidine kinase activity
FF125_10600	COG3850	Histidine kinase
FF125_10630	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
FF125_10640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FF125_10650	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FF125_10660	COG0110	maltose O-acetyltransferase activity
FF125_10670	COG0791	NLP P60 protein
FF125_10680	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FF125_10700	COG2211	Major facilitator Superfamily
FF125_10715	COG1278	Cold shock
FF125_10735	COG0697	spore germination
FF125_10765	COG0339	signal peptide processing
FF125_10775	COG3548	integral membrane protein
FF125_10795	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FF125_10820	COG4585	Histidine kinase
FF125_10850	COG2308	Evidence 4 Homologs of previously reported genes of
FF125_10860	COG1305	Transglutaminase-like
FF125_10870	COG2066	Belongs to the glutaminase family
FF125_10875	COG2095	MarC family integral membrane protein
FF125_10890	COG1979	alcohol dehydrogenase
FF125_10895	COG2130	NADP-dependent
FF125_10910	COG1309	transcriptional regulator
FF125_10925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FF125_10930	COG1136	(ABC) transporter
FF125_10935	COG0577	efflux transmembrane transporter activity
FF125_10935	COG1136	(ABC) transporter
FF125_10950	COG3275	phosphorelay sensor kinase activity
FF125_10955	COG3279	Response regulator of the LytR AlgR family
FF125_10990	COG3590	peptidase
FF125_11015	COG0246	Mannitol dehydrogenase
FF125_11020	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FF125_11020	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FF125_11030	COG4181	ATPase activity
FF125_11035	COG1136	(ABC) transporter
FF125_11035	COG0577	efflux transmembrane transporter activity
FF125_11040	COG3239	Fatty acid desaturase
FF125_11050	COG1278	Cold shock
FF125_11070	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
FF125_11090	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_11095	COG4628	conserved protein (DUF2132)
FF125_11100	COG0189	ligase activity
FF125_11105	COG0189	ligase activity
FF125_11105	COG4067	protein conserved in archaea
FF125_11110	COG0668	transmembrane transport
FF125_11135	COG3279	Response regulator of the LytR AlgR family
FF125_11140	COG3275	phosphorelay sensor kinase activity
FF125_11155	COG0352	thiamine-phosphate diphosphorylase activity
FF125_11160	COG0513	Belongs to the DEAD box helicase family
FF125_11165	COG1960	acyl-CoA dehydrogenase activity
FF125_11190	COG1289	transmembrane transporter activity
FF125_11205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FF125_11215	COG1309	transcriptional regulator
FF125_11220	COG4221	oxidoreductase activity
FF125_11235	COG3119	arylsulfatase activity
FF125_11245	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FF125_11310	COG3046	protein related to deoxyribodipyrimidine photolyase
FF125_11330	COG0067	glutamate synthase
FF125_11330	COG0069	glutamate synthase activity
FF125_11330	COG0070	glutamate synthase
FF125_11400	COG2827	Endonuclease containing a URI domain
FF125_11415	COG2814	Major facilitator Superfamily
FF125_11425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FF125_11440	COG0022	dehydrogenase e1 component
FF125_11445	COG1522	sequence-specific DNA binding
FF125_11460	COG0308	aminopeptidase N
FF125_11505	COG4974	Belongs to the 'phage' integrase family
FF125_11515	COG4974	Belongs to the 'phage' integrase family
FF125_11520	COG2095	MarC family integral membrane protein
FF125_11580	COG4977	sequence-specific DNA binding
FF125_11605	COG0456	acetyltransferase
FF125_11610	COG3657	addiction module killer protein
FF125_11615	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FF125_11655	COG2801	Transposase and inactivated derivatives
FF125_11660	COG3328	transposase activity
FF125_11670	COG2814	Major facilitator Superfamily
FF125_11700	COG4974	Belongs to the 'phage' integrase family
FF125_11720	COG2274	protein secretion by the type I secretion system
FF125_11725	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FF125_11770	COG0745	RESPONSE REGULATOR receiver
FF125_11770	COG2205	protein histidine kinase activity
FF125_11770	COG3292	Two component regulator propeller
FF125_11775	COG1242	4 iron, 4 sulfur cluster binding
FF125_11805	COG0632	four-way junction helicase activity
FF125_11825	COG2207	Transcriptional regulator
FF125_11835	COG4251	negative regulation of phosphorylation
FF125_11840	COG0784	Response regulator, receiver
FF125_11885	COG2323	membrane
FF125_11900	COG1012	belongs to the aldehyde dehydrogenase family
FF125_11925	COG0673	inositol 2-dehydrogenase activity
FF125_11935	COG3408	Glycogen debranching enzyme
FF125_11935	COG3119	arylsulfatase activity
FF125_11950	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FF125_11960	COG4771	TonB-dependent receptor
FF125_11965	COG0745	RESPONSE REGULATOR receiver
FF125_11965	COG2205	protein histidine kinase activity
FF125_11965	COG3292	Two component regulator propeller
FF125_11980	COG1322	Protein conserved in bacteria
FF125_11985	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FF125_12025	COG0367	asparagine synthase
FF125_12035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FF125_12040	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FF125_12045	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FF125_12050	COG0456	acetyltransferase
FF125_12075	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FF125_12085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FF125_12090	COG0438	transferase activity, transferring glycosyl groups
FF125_12105	COG1216	Glycosyl transferase, family 2
FF125_12110	COG0438	transferase activity, transferring glycosyl groups
FF125_12140	COG3340	Belongs to the peptidase S51 family
FF125_12170	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FF125_12175	COG1702	phosphate starvation-inducible protein PhoH
FF125_12180	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
FF125_12225	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FF125_12240	COG0629	single-stranded DNA binding
FF125_12250	COG0280	phosphate acetyltransferase
FF125_12250	COG0857	belongs to the CobB CobQ family
FF125_12255	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FF125_12260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FF125_12275	COG5487	UPF0391 membrane protein
FF125_12285	COG0668	transmembrane transport
FF125_12310	COG0183	Belongs to the thiolase family
FF125_12330	COG0542	response to heat
FF125_12350	COG0514	ATP-dependent DNA helicase (RecQ)
FF125_12355	COG0564	pseudouridine synthase activity
FF125_12365	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
FF125_12370	COG2986	histidine ammonia-lyase
FF125_12375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FF125_12380	COG0628	permease
FF125_12390	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FF125_12395	COG3383	formate dehydrogenase (NAD+) activity
FF125_12400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FF125_12405	COG0825	malonyl-CoA metabolic process
FF125_12410	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FF125_12415	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FF125_12455	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_12460	COG0612	Peptidase, M16
FF125_12465	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FF125_12470	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FF125_12480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FF125_12485	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FF125_12490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FF125_12490	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FF125_12495	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FF125_12500	COG1078	dGTPase activity
FF125_12505	COG2204	response regulator
FF125_12510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FF125_12515	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FF125_12520	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FF125_12530	COG3275	phosphorelay sensor kinase activity
FF125_12590	COG3119	arylsulfatase activity
FF125_12600	COG0131	Imidazoleglycerol-phosphate dehydratase
FF125_12605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FF125_12610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FF125_12620	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FF125_12640	COG2195	Cleaves the N-terminal amino acid of tripeptides
FF125_12645	COG0019	diaminopimelate decarboxylase activity
FF125_12660	COG0006	proline dipeptidase activity
FF125_12665	COG0460	homoserine dehydrogenase
FF125_12665	COG0527	aspartate kinase activity
FF125_12670	COG0083	homoserine kinase activity
FF125_12695	COG3275	phosphorelay sensor kinase activity
FF125_12715	COG2353	YceI-like domain
FF125_12725	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FF125_12750	COG1132	(ABC) transporter
FF125_12755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FF125_12765	COG1862	Preprotein translocase
FF125_12775	COG0237	dephospho-CoA kinase activity
FF125_12825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FF125_12825	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FF125_12830	COG0247	lactate metabolic process
FF125_12830	COG0277	FAD linked oxidase domain protein
FF125_12845	COG0681	Belongs to the peptidase S26 family
FF125_12850	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FF125_12860	COG1475	DNA binding
FF125_12865	COG1192	Involved in chromosome partitioning
FF125_12870	COG0612	Peptidase, M16
FF125_12875	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_12880	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FF125_12900	COG3119	arylsulfatase activity
FF125_12905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FF125_12915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FF125_12930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FF125_12950	COG0484	heat shock protein binding
FF125_12955	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FF125_12960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FF125_12970	COG0210	DNA helicase
FF125_13020	COG1462	curli production assembly transport component CsgG
FF125_13065	COG0673	inositol 2-dehydrogenase activity
FF125_13075	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FF125_13080	COG3250	beta-galactosidase activity
FF125_13085	COG3537	Alpha-1,2-mannosidase
FF125_13095	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
FF125_13105	COG3537	Alpha-1,2-mannosidase
FF125_13115	COG3279	Response regulator of the LytR AlgR family
FF125_13120	COG0363	glucosamine-6-phosphate deaminase activity
FF125_13150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FF125_13155	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FF125_13185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FF125_13230	COG0321	lipoyl(octanoyl) transferase activity
FF125_13230	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
FF125_13240	COG3119	arylsulfatase activity
FF125_13245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FF125_13250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FF125_13285	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FF125_13295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FF125_13315	COG0626	cystathionine gamma-synthase activity
FF125_13320	COG0386	Belongs to the glutathione peroxidase family
FF125_13325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FF125_13325	COG1333	cytochrome c biogenesis protein
FF125_13340	COG1295	ribonuclease BN
FF125_13365	COG0589	response to stress
FF125_13375	COG0589	response to stress
FF125_13395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FF125_13415	COG2202	Pas domain
FF125_13415	COG1366	Belongs to the anti-sigma-factor antagonist family
FF125_13420	COG0745	RESPONSE REGULATOR receiver
FF125_13445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FF125_13455	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FF125_13465	COG4263	nitrous-oxide reductase activity
FF125_13490	COG4152	abc transporter atp-binding protein
FF125_13510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FF125_13515	COG0076	glutamate decarboxylase activity
FF125_13605	COG0438	transferase activity, transferring glycosyl groups
FF125_13610	COG0438	transferase activity, transferring glycosyl groups
FF125_13620	COG1012	belongs to the aldehyde dehydrogenase family
FF125_13625	COG1472	Belongs to the glycosyl hydrolase 3 family
FF125_13665	COG2217	Heavy metal translocating P-type atpase
FF125_13680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FF125_13705	COG0359	binds to the 23S rRNA
FF125_13710	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FF125_13715	COG0360	Binds together with S18 to 16S ribosomal RNA
FF125_13730	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_13735	COG1312	Catalyzes the dehydration of D-mannonate
FF125_13740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FF125_13770	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FF125_13795	COG1899	peptidyl-lysine modification to peptidyl-hypusine
FF125_13800	COG0010	Belongs to the arginase family
FF125_13805	COG1166	arginine decarboxylase activity
FF125_13815	COG1560	Kdo2-lipid A biosynthetic process
FF125_13825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FF125_13840	COG0343	queuine tRNA-ribosyltransferase activity
FF125_13845	COG0012	GTP binding
FF125_13855	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FF125_13870	COG0302	gtp cyclohydrolase
FF125_13875	COG0124	histidyl-tRNA synthetase
FF125_13890	COG2096	Adenosyltransferase
FF125_13900	COG0653	protein targeting
FF125_13935	COG1266	CAAX protease self-immunity
FF125_13940	COG4948	Mandelate Racemase Muconate Lactonizing
FF125_13950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
FF125_13965	COG1575	Belongs to the MenA family. Type 1 subfamily
FF125_13975	COG0247	lactate metabolic process
FF125_13975	COG2181	nitrate reductase activity
FF125_13980	COG0247	lactate metabolic process
FF125_13980	COG2181	nitrate reductase activity
FF125_13990	COG0860	N-Acetylmuramoyl-L-alanine amidase
FF125_13995	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
FF125_14000	COG1917	Cupin 2, conserved barrel domain protein
FF125_14000	COG2169	Transcriptional regulator
FF125_14025	COG0702	epimerase
FF125_14035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FF125_14045	COG0438	transferase activity, transferring glycosyl groups
FF125_14050	COG0494	nUDIX hydrolase
FF125_14060	COG0783	Belongs to the Dps family
FF125_14080	COG1482	cell wall glycoprotein biosynthetic process
FF125_14085	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FF125_14090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FF125_14095	COG0667	Aldo Keto reductase
FF125_14100	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
FF125_14115	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FF125_14120	COG0673	inositol 2-dehydrogenase activity
FF125_14125	COG1250	3-hydroxyacyl-CoA dehydrogenase
FF125_14130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FF125_14135	COG0577	efflux transmembrane transporter activity
FF125_14135	COG1136	(ABC) transporter
FF125_14140	COG0577	efflux transmembrane transporter activity
FF125_14145	COG1136	(ABC) transporter
FF125_14150	COG3011	Protein conserved in bacteria
FF125_14160	COG1301	dicarboxylic acid transport
FF125_14185	COG0302	gtp cyclohydrolase
FF125_14190	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FF125_14215	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FF125_14225	COG2194	sulfuric ester hydrolase activity
FF125_14240	COG1984	allophanate hydrolase subunit 2
FF125_14245	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FF125_14250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FF125_14255	COG1914	H( )-stimulated, divalent metal cation uptake system
FF125_14270	COG0606	chelatase, subunit chli
FF125_14280	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
FF125_14290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FF125_14300	COG3813	Protein conserved in bacteria
FF125_14405	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FF125_14465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FF125_14490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FF125_14495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FF125_14530	COG1136	(ABC) transporter
FF125_14535	COG0577	efflux transmembrane transporter activity
FF125_14555	COG0577	efflux transmembrane transporter activity
FF125_14560	COG0577	efflux transmembrane transporter activity
FF125_14565	COG0577	efflux transmembrane transporter activity
FF125_14570	COG0577	efflux transmembrane transporter activity
FF125_14585	COG0577	efflux transmembrane transporter activity
FF125_14585	COG1136	(ABC) transporter
FF125_14605	COG1131	(ABC) transporter
FF125_14630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FF125_14645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FF125_14650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FF125_14655	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_14670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FF125_14680	COG0587	DNA-directed DNA polymerase activity
FF125_14700	COG3844	kynureninase activity
FF125_14705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FF125_14720	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_14740	COG3185	4-Hydroxyphenylpyruvate dioxygenase
FF125_14755	COG0489	protein tyrosine kinase activity
FF125_14765	COG1040	competence protein
FF125_14770	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FF125_14780	COG0423	glycine-tRNA ligase activity
FF125_14795	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
FF125_14805	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FF125_14830	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_14865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FF125_14870	COG0084	hydrolase, TatD family'
FF125_14895	COG0590	tRNA wobble adenosine to inosine editing
FF125_14915	COG1228	amidohydrolase
FF125_14930	COG0545	Peptidyl-prolyl cis-trans isomerase
FF125_14960	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FF125_14965	COG0085	RNA polymerase activity
FF125_14970	COG0222	ribosome binding
FF125_14975	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FF125_14980	COG0081	regulation of translation
FF125_14985	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FF125_15005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FF125_15035	COG4974	Belongs to the 'phage' integrase family
FF125_15040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FF125_15050	COG0471	metal ion transport
FF125_15070	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FF125_15075	COG0401	homolog of Blt101
FF125_15085	COG0321	lipoyl(octanoyl) transferase activity
FF125_15200	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FF125_15210	COG1757	Na H antiporter
FF125_15240	COG3119	arylsulfatase activity
FF125_15265	COG0657	acetylesterase activity
FF125_15265	COG2755	lipolytic protein G-D-S-L family
FF125_15270	COG3119	arylsulfatase activity
FF125_15275	COG3119	arylsulfatase activity
FF125_15295	COG3525	Glycosyl hydrolase, family 20, catalytic domain
FF125_15305	COG3250	beta-galactosidase activity
FF125_15315	COG0285	dihydrofolate synthase activity
FF125_15325	COG0848	biopolymer transport protein
FF125_15335	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FF125_15345	COG1960	acyl-CoA dehydrogenase activity
FF125_15360	COG0101	tRNA pseudouridine synthase activity
FF125_15370	COG0004	ammonium transporteR
FF125_15380	COG0004	ammonium transporteR
FF125_15385	COG0067	glutamate synthase
FF125_15385	COG0069	glutamate synthase activity
FF125_15385	COG0070	glutamate synthase
FF125_15410	COG3119	arylsulfatase activity
FF125_15455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FF125_15470	COG1611	Belongs to the LOG family
FF125_15485	COG0022	dehydrogenase e1 component
FF125_15515	COG1216	Glycosyl transferase, family 2
FF125_15515	COG0463	Glycosyl transferase, family 2
FF125_15525	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FF125_15530	COG0497	DNA recombination
FF125_15535	COG1119	ATPase activity
FF125_15540	COG3119	arylsulfatase activity
FF125_15565	COG1528	Iron-storage protein
FF125_15570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FF125_15585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FF125_15600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FF125_15610	COG0583	DNA-binding transcription factor activity
FF125_15615	COG2855	membrane
FF125_15670	COG0513	Belongs to the DEAD box helicase family
FF125_15675	COG0561	phosphatase activity
FF125_15680	COG0018	arginyl-trna synthetase
FF125_15690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FF125_15700	COG0484	heat shock protein binding
FF125_15710	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FF125_15710	COG0662	Cupin 2, conserved barrel domain protein
FF125_15725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FF125_15730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FF125_15735	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
FF125_15740	COG1335	isochorismatase
FF125_15745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FF125_15750	COG4974	Belongs to the 'phage' integrase family
FF125_15765	COG1418	mRNA catabolic process
FF125_15800	COG1595	DNA-templated transcription, initiation
FF125_15820	COG0488	(ABC) transporter
FF125_15840	COG2270	Major facilitator Superfamily
FF125_15855	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FF125_15865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FF125_15880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FF125_15885	COG1262	PFAM Formylglycine-generating sulfatase enzyme
FF125_15900	COG0295	cytidine deaminase activity
FF125_15910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FF125_15920	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FF125_15925	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FF125_15945	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_15970	COG0254	rRNA binding
FF125_15985	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FF125_16020	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FF125_16030	COG0572	uridine kinase
FF125_16040	COG2133	pyrroloquinoline quinone binding
FF125_16050	COG4974	Belongs to the 'phage' integrase family
FF125_16070	COG4974	Belongs to the 'phage' integrase family
FF125_16140	COG2801	Transposase and inactivated derivatives
FF125_16150	COG2814	Major facilitator Superfamily
FF125_16180	COG4974	Belongs to the 'phage' integrase family
FF125_16195	COG0745	RESPONSE REGULATOR receiver
FF125_16240	COG3279	Response regulator of the LytR AlgR family
FF125_16250	COG4251	negative regulation of phosphorylation
FF125_16260	COG4251	negative regulation of phosphorylation
FF125_16270	COG0784	Response regulator, receiver
FF125_16295	COG1187	pseudouridine synthase activity
FF125_16300	COG3254	rhamnose metabolic process
FF125_16315	COG1408	metallophosphoesterase
FF125_16330	COG0492	ferredoxin-NADP+ reductase activity
FF125_16360	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FF125_16375	COG3867	Arabinogalactan endo-beta-1,4-galactanase
FF125_16385	COG1703	isobutyryl-CoA mutase activity
FF125_16395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FF125_16395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FF125_16400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FF125_16405	COG0427	acetyl-CoA hydrolase
FF125_16410	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
FF125_16415	COG0511	ligase activity, forming carbon-carbon bonds
FF125_16425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FF125_16430	COG0346	lactoylglutathione lyase activity
FF125_16435	COG0504	CTP synthase activity
FF125_16460	COG0813	purine-nucleoside phosphorylase activity
FF125_16480	COG0516	GMP reductase activity
FF125_16480	COG0517	IMP dehydrogenase activity
FF125_16495	COG1730	sister chromatid segregation
FF125_16500	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FF125_16505	COG1193	negative regulation of DNA recombination
FF125_16515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FF125_16515	COG3743	rRNA binding
FF125_16535	COG0438	transferase activity, transferring glycosyl groups
FF125_16580	COG0385	Bile acid
FF125_16590	COG1472	Belongs to the glycosyl hydrolase 3 family
FF125_16630	COG0408	coproporphyrinogen oxidase activity
FF125_16650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FF125_16655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FF125_16665	COG0113	porphobilinogen synthase activity
FF125_16670	COG0181	hydroxymethylbilane synthase activity
FF125_16675	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FF125_16695	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FF125_16705	COG1981	membrane
FF125_16710	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FF125_16715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FF125_16720	COG0259	pyridoxamine-phosphate oxidase activity
FF125_16745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FF125_16755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FF125_16765	COG1970	mechanosensitive ion channel activity
FF125_16770	COG1595	DNA-templated transcription, initiation
FF125_16815	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FF125_16820	COG0574	Belongs to the PEP-utilizing enzyme family
FF125_16820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FF125_16825	COG1022	Amp-dependent synthetase and ligase
FF125_16860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
FF125_16885	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FF125_16945	COG0148	phosphopyruvate hydratase activity
FF125_16950	COG0505	Belongs to the CarA family
FF125_16955	COG0203	ribosomal protein L17
FF125_16960	COG0202	RNA polymerase activity
FF125_16965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FF125_16970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FF125_16975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FF125_16980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FF125_16985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FF125_16995	COG0200	Binds to the 23S rRNA
FF125_17000	COG1841	ribosomal large subunit assembly
FF125_17005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FF125_17010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FF125_17015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FF125_17020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FF125_17025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FF125_17030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FF125_17035	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FF125_17040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FF125_17045	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FF125_17050	COG0255	Belongs to the universal ribosomal protein uL29 family
FF125_17055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FF125_17060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FF125_17065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FF125_17070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FF125_17075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FF125_17080	COG0089	rRNA binding
FF125_17085	COG0088	Forms part of the polypeptide exit tunnel
FF125_17090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FF125_17095	COG0051	transcription antitermination factor activity, RNA binding
FF125_17100	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FF125_17105	COG0049	tRNA binding
FF125_17110	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FF125_17120	COG1629	transport
FF125_17140	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FF125_17150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FF125_17160	COG0546	phosphoglycolate phosphatase activity
FF125_17170	COG0297	glycogen (starch) synthase activity
FF125_17170	COG0438	transferase activity, transferring glycosyl groups
FF125_17190	COG2003	Belongs to the UPF0758 family
FF125_17195	COG0569	domain protein
FF125_17210	COG1629	transport
FF125_17225	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FF125_17225	COG1703	isobutyryl-CoA mutase activity
FF125_17225	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FF125_17230	COG2814	Major facilitator Superfamily
FF125_17240	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FF125_17255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FF125_17270	COG1611	Belongs to the LOG family
FF125_17275	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FF125_17290	COG1132	(ABC) transporter
FF125_17295	COG0101	tRNA pseudouridine synthase activity
FF125_17415	COG1793	dna ligase
FF125_17415	COG3285	dna ligase
FF125_17425	COG1360	Flagellar Motor Protein
FF125_17435	COG0450	alkyl hydroperoxide reductase
FF125_17450	COG2954	triphosphatase activity
FF125_17480	COG0071	Belongs to the small heat shock protein (HSP20) family
FF125_17485	COG0366	Alpha amylase catalytic
FF125_17495	COG2819	hydrolase of the alpha beta superfamily
FF125_17500	COG0366	Alpha amylase catalytic
FF125_17505	COG1082	Xylose isomerase domain protein TIM barrel
FF125_17510	COG1554	hydrolase, family 65, central catalytic
FF125_17515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FF125_17520	COG2190	(PTS) system
FF125_17520	COG2211	Major facilitator Superfamily
FF125_17525	COG1609	Transcriptional regulator
FF125_17530	COG4206	TonB-dependent receptor
FF125_17530	COG1629	transport
FF125_17545	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FF125_17550	COG0673	inositol 2-dehydrogenase activity
FF125_17585	COG0673	inositol 2-dehydrogenase activity
FF125_17605	COG1490	D-aminoacyl-tRNA deacylase activity
FF125_17635	COG1999	signal sequence binding
FF125_17645	COG0750	zinc metalloprotease
FF125_17655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FF125_17660	COG1629	transport
FF125_17680	COG0196	riboflavin kinase activity
FF125_17685	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FF125_17700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FF125_17705	COG2239	Acts as a magnesium transporter
FF125_17710	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
FF125_17715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FF125_17730	COG1595	DNA-templated transcription, initiation
FF125_17740	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FF125_17780	COG1510	regulation of RNA biosynthetic process
FF125_17790	COG1090	epimerase
FF125_17795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FF125_17830	COG0165	Argininosuccinate lyase
FF125_17840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FF125_17850	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FF125_17855	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FF125_17860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FF125_17865	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FF125_17870	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FF125_17875	COG0137	argininosuccinate synthase activity
FF125_17885	COG0741	lytic transglycosylase activity
FF125_17890	COG1388	LysM domain
FF125_17890	COG0741	lytic transglycosylase activity
FF125_17900	COG1477	protein flavinylation
FF125_17905	COG1360	Flagellar Motor Protein
FF125_17915	COG1333	cytochrome c biogenesis protein
FF125_17915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FF125_17920	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FF125_17950	COG1629	transport
FF125_17955	COG0673	inositol 2-dehydrogenase activity
FF125_17970	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FF125_17975	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FF125_17980	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FF125_17985	COG1805	sodium ion transport
FF125_17990	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
FF125_18000	COG2967	ApaG domain
FF125_18035	COG1012	belongs to the aldehyde dehydrogenase family
FF125_18045	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FF125_18065	COG0357	Ribosomal RNA small subunit methyltransferase G
FF125_18070	COG3239	Fatty acid desaturase
FF125_18075	COG0436	Aminotransferase
FF125_18145	COG0860	N-Acetylmuramoyl-L-alanine amidase
FF125_18195	COG2003	Belongs to the UPF0758 family
FF125_18205	COG0629	single-stranded DNA binding
FF125_18225	COG0800	Aldolase
FF125_18245	COG3119	arylsulfatase activity
FF125_18270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FF125_18290	COG2814	Major facilitator Superfamily
FF125_18310	COG1024	Enoyl-CoA hydratase
FF125_18315	COG1012	belongs to the aldehyde dehydrogenase family
FF125_18330	COG3250	beta-galactosidase activity
FF125_18350	COG3328	transposase activity
FF125_18355	COG0457	Tetratricopeptide repeat
FF125_18365	COG3250	beta-galactosidase activity
FF125_18380	COG1472	Belongs to the glycosyl hydrolase 3 family
FF125_18385	COG1472	Belongs to the glycosyl hydrolase 3 family
FF125_18395	COG3250	beta-galactosidase activity
FF125_18415	COG3119	arylsulfatase activity
FF125_18425	COG3408	Glycogen debranching enzyme
FF125_18425	COG3119	arylsulfatase activity
FF125_18430	COG3250	beta-galactosidase activity
FF125_18435	COG3119	arylsulfatase activity
FF125_18450	COG4771	TonB-dependent receptor
FF125_18455	COG3250	beta-galactosidase activity
FF125_18475	COG1063	alcohol dehydrogenase
FF125_18485	COG0800	Aldolase
FF125_18490	COG2721	sulfolactate sulfo-lyase activity
FF125_18495	COG0246	Mannitol dehydrogenase
FF125_18510	COG0738	Major facilitator superfamily
FF125_18525	COG3292	Two component regulator propeller
FF125_18525	COG2205	protein histidine kinase activity
FF125_18525	COG0745	RESPONSE REGULATOR receiver
FF125_18550	COG3250	beta-galactosidase activity
FF125_18555	COG1063	alcohol dehydrogenase
FF125_18560	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_18565	COG1012	belongs to the aldehyde dehydrogenase family
FF125_18570	COG3119	arylsulfatase activity
FF125_18575	COG4948	Mandelate Racemase Muconate Lactonizing
FF125_18595	COG1472	Belongs to the glycosyl hydrolase 3 family
FF125_18600	COG1472	Belongs to the glycosyl hydrolase 3 family
FF125_18605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FF125_18610	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
FF125_18615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FF125_18625	COG0702	epimerase
FF125_18630	COG0702	epimerase
FF125_18650	COG3408	Glycogen debranching enzyme
FF125_18650	COG3119	arylsulfatase activity
FF125_18655	COG3119	arylsulfatase activity
FF125_18670	COG1725	Transcriptional regulator
FF125_18680	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
FF125_18685	COG1085	galactose-1-phosphate uridylyltransferase
FF125_18695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FF125_18705	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FF125_18730	COG3328	transposase activity
FF125_18750	COG3938	Belongs to the proline racemase family
FF125_18775	COG2824	Alkylphosphonate utilization operon protein PhnA
FF125_18780	COG2315	Protein conserved in bacteria
FF125_18800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FF125_18805	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FF125_18830	COG2188	Transcriptional regulator
FF125_18840	COG3537	Alpha-1,2-mannosidase
FF125_18860	COG0383	alpha-mannosidase activity
FF125_18865	COG2814	Major facilitator Superfamily
FF125_18865	COG0477	Major facilitator Superfamily
FF125_18875	COG0473	3-isopropylmalate dehydrogenase activity
FF125_18875	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FF125_18880	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_18885	COG2706	6-phosphogluconolactonase activity
FF125_18890	COG1312	Catalyzes the dehydration of D-mannonate
FF125_18980	COG0745	RESPONSE REGULATOR receiver
FF125_18980	COG2972	Histidine kinase
FF125_18985	COG3279	Response regulator of the LytR AlgR family
FF125_19085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
FF125_19100	COG3118	belongs to the thioredoxin family
FF125_19105	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FF125_19115	COG1410	methionine synthase
FF125_19115	COG0646	methionine synthase
FF125_19120	COG2329	Antibiotic biosynthesis monooxygenase
FF125_19125	COG0646	methionine synthase
FF125_19125	COG1410	methionine synthase
FF125_19135	COG1045	serine acetyltransferase
FF125_19140	COG0633	Ferredoxin
FF125_19145	COG0492	ferredoxin-NADP+ reductase activity
FF125_19150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FF125_19150	COG1648	precorrin-2 dehydrogenase activity
FF125_19155	COG1648	precorrin-2 dehydrogenase activity
FF125_19155	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FF125_19160	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FF125_19175	COG0175	sulfate reduction
FF125_19185	COG0318	PFAM AMP-dependent synthetase and ligase
FF125_19190	COG1959	2 iron, 2 sulfur cluster binding
FF125_19200	COG0460	homoserine dehydrogenase
FF125_19200	COG0527	aspartate kinase activity
FF125_19215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FF125_19230	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FF125_19260	COG5434	Belongs to the glycosyl hydrolase 28 family
FF125_19265	COG3263	regulation of cellular component size
FF125_19270	COG0659	secondary active sulfate transmembrane transporter activity
FF125_19275	COG0484	heat shock protein binding
FF125_19295	COG2234	aminopeptidase activity
FF125_19340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FF125_19345	COG0346	lactoylglutathione lyase activity
FF125_19350	COG2177	Part of the ABC transporter FtsEX involved in
FF125_19360	COG1968	undecaprenyl-diphosphatase activity
FF125_19365	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FF125_19375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FF125_19405	COG1530	ribonuclease E activity
FF125_19410	COG0776	regulation of translation
FF125_19420	COG0629	single-stranded DNA binding
FF125_19435	COG1612	heme a metabolic process
FF125_19450	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FF125_19455	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FF125_19465	COG0756	dUTP diphosphatase activity
FF125_19475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FF125_19495	COG0739	heme binding
FF125_19500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FF125_19520	COG0174	glutamine synthetase
FF125_19535	COG1629	transport
FF125_19565	COG4771	TonB-dependent receptor
FF125_19570	COG0702	epimerase
FF125_19575	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
FF125_19580	COG0800	Aldolase
FF125_19585	COG0205	6-phosphofructokinase activity
FF125_19600	COG1609	Transcriptional regulator
FF125_19605	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_19610	COG2271	Major facilitator Superfamily
FF125_19615	COG2186	Transcriptional regulator
FF125_19640	COG0702	epimerase
FF125_19665	COG1609	Transcriptional regulator
FF125_19680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
FF125_19685	COG1904	glucuronate isomerase
FF125_19690	COG1312	Catalyzes the dehydration of D-mannonate
FF125_19695	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_19725	COG2264	protein methyltransferase activity
FF125_19730	COG0149	triose-phosphate isomerase activity
FF125_19735	COG0284	orotidine-5'-phosphate decarboxylase activity
FF125_19745	COG1160	GTP binding
FF125_19750	COG1648	precorrin-2 dehydrogenase activity
FF125_19750	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FF125_19760	COG0243	molybdopterin cofactor binding
FF125_19775	COG2223	nitrite transmembrane transporter activity
FF125_19785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FF125_19805	COG2807	transmembrane transport
FF125_19825	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
FF125_19855	COG0006	proline dipeptidase activity
FF125_19860	COG3250	beta-galactosidase activity
FF125_19880	COG2226	methyltransferase
FF125_19890	COG0045	succinate-CoA ligase (ADP-forming) activity
FF125_19890	COG1042	CoA-binding domain protein
FF125_19890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FF125_19900	COG0798	PFAM Bile acid sodium symporter
FF125_19950	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
FF125_19950	COG5297	Belongs to the glycosyl hydrolase family 6
FF125_19965	COG0464	growth
FF125_19975	COG0546	phosphoglycolate phosphatase activity
FF125_19980	COG0667	Aldo Keto reductase
FF125_19985	COG1288	antiporter activity
FF125_20005	COG1114	Component of the transport system for branched-chain amino acids
FF125_20015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FF125_20025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FF125_20065	COG1418	mRNA catabolic process
FF125_20105	COG1024	Enoyl-CoA hydratase
FF125_20120	COG0159	tryptophan synthase activity
FF125_20125	COG0133	tryptophan synthase activity
FF125_20130	COG0135	phosphoribosylanthranilate isomerase activity
FF125_20135	COG0134	indole-3-glycerol-phosphate synthase activity
FF125_20140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FF125_20145	COG0512	Glutamine amidotransferase of anthranilate synthase
FF125_20150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FF125_20170	COG0686	Belongs to the AlaDH PNT family
FF125_20175	COG0495	leucyl-tRNA aminoacylation
FF125_20180	COG0402	S-adenosylhomocysteine deaminase activity
FF125_20190	COG0367	asparagine synthase
FF125_20200	COG0745	RESPONSE REGULATOR receiver
FF125_20205	COG5002	protein histidine kinase activity
FF125_20220	COG0187	DNA topoisomerase II activity
FF125_20225	COG0039	L-malate dehydrogenase activity
FF125_20240	COG2759	Belongs to the formate--tetrahydrofolate ligase family
FF125_20245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FF125_20250	COG0563	adenylate kinase activity
FF125_20255	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FF125_20265	COG4895	conserved protein (DUF2196)
FF125_20295	COG0481	GTPase activity
FF125_20340	COG1349	DNA-binding transcription factor activity
FF125_20345	COG3876	Protein conserved in bacteria
FF125_20350	COG1629	transport
FF125_20370	COG0156	8-amino-7-oxononanoate synthase activity
FF125_20375	COG4948	Mandelate Racemase Muconate Lactonizing
FF125_20385	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FF125_20385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FF125_20415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FF125_20420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FF125_20425	COG1185	polyribonucleotide nucleotidyltransferase activity
FF125_20430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FF125_20435	COG0095	Lipoate-protein ligase
FF125_20440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FF125_20445	COG0191	fructose-bisphosphate aldolase activity
FF125_20455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FF125_20465	COG2226	methyltransferase
FF125_20470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FF125_20480	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FF125_20490	COG4771	TonB-dependent receptor
FF125_20510	COG0436	Aminotransferase
FF125_20515	COG4717	serine-type aminopeptidase activity
FF125_20535	COG4935	Belongs to the peptidase S8 family
FF125_20535	COG2234	aminopeptidase activity
FF125_20545	COG4555	ABC transporter
FF125_20550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FF125_20555	COG1053	succinate dehydrogenase
FF125_20570	COG0189	ligase activity
FF125_20605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FF125_20610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FF125_20625	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FF125_20640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FF125_20655	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FF125_20670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FF125_20690	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
FF125_20700	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FF125_20715	COG1028	Short-chain dehydrogenase reductase Sdr
FF125_20720	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FF125_20725	COG2267	carboxylic ester hydrolase activity
FF125_20735	COG2885	chlorophyll binding
FF125_20745	COG4536	flavin adenine dinucleotide binding
FF125_20775	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FF125_20805	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FF125_20815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FF125_20820	COG0590	tRNA wobble adenosine to inosine editing
FF125_20835	COG2197	response regulator
FF125_20840	COG1428	Deoxynucleoside kinase
FF125_20850	COG0659	secondary active sulfate transmembrane transporter activity
FF125_20855	COG3263	regulation of cellular component size
FF125_20865	COG0492	ferredoxin-NADP+ reductase activity
FF125_20875	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FF125_20880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FF125_20885	COG0297	glycogen (starch) synthase activity
FF125_20895	COG1573	uracil-dna glycosylase
FF125_20905	COG2268	Band 7 protein
FF125_20910	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FF125_20925	COG0793	Belongs to the peptidase S41A family
FF125_20925	COG3409	Peptidoglycan-binding domain 1 protein
FF125_20935	COG2095	MarC family integral membrane protein
FF125_20945	COG3275	phosphorelay sensor kinase activity
FF125_21000	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FF125_21000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FF125_21030	COG1629	transport
FF125_21040	COG0166	Belongs to the GPI family
FF125_21060	COG3483	tryptophan 2,3-dioxygenase activity
FF125_21065	COG0037	tRNA processing
FF125_21070	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FF125_21075	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FF125_21085	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FF125_21090	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FF125_21095	COG0193	aminoacyl-tRNA hydrolase activity
FF125_21100	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FF125_21110	COG0297	glycogen (starch) synthase activity
FF125_21115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FF125_21120	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FF125_21135	COG2081	HI0933 family
FF125_21165	COG3279	Response regulator of the LytR AlgR family
FF125_21170	COG0697	spore germination
FF125_21200	COG1187	pseudouridine synthase activity
FF125_21205	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FF125_21210	COG0534	Mate efflux family protein
FF125_21215	COG2333	competence protein COMEC
FF125_21215	COG0658	competence protein
FF125_21220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FF125_21250	COG0758	DNA mediated transformation
FF125_21250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FF125_21265	COG0288	reversible hydration of carbon dioxide
FF125_21270	COG0659	secondary active sulfate transmembrane transporter activity
FF125_21285	COG0156	8-amino-7-oxononanoate synthase activity
FF125_21290	COG0720	synthase
FF125_21300	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FF125_21305	COG2226	methyltransferase
FF125_21330	COG3177	Filamentation induced by cAMP protein fic
FF125_21350	COG0450	alkyl hydroperoxide reductase
FF125_21365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FF125_21390	COG2197	response regulator
FF125_21395	COG1253	flavin adenine dinucleotide binding
FF125_21410	COG2151	metal-sulfur cluster biosynthetic enzyme
FF125_21415	COG2166	iron-sulfur cluster assembly
FF125_21440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FF125_21460	COG1309	transcriptional regulator
FF125_21490	COG0438	transferase activity, transferring glycosyl groups
FF125_21495	COG3420	alginic acid biosynthetic process
FF125_21515	COG4221	oxidoreductase activity
FF125_21520	COG1012	belongs to the aldehyde dehydrogenase family
FF125_21530	COG1595	DNA-templated transcription, initiation
FF125_21550	COG1309	transcriptional regulator
FF125_21590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FF125_21595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FF125_21605	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FF125_21610	COG0463	Glycosyl transferase, family 2
FF125_21625	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FF125_21635	COG2153	protein acetylation
FF125_21640	COG0698	ribose 5-phosphate isomerase
FF125_21650	COG0557	exoribonuclease II activity
FF125_21660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FF125_21675	COG1607	acyl-coa hydrolase
FF125_21680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FF125_21700	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FF125_21705	COG0445	tRNA wobble uridine modification
FF125_21715	COG2264	protein methyltransferase activity
FF125_21725	COG2885	chlorophyll binding
FF125_21740	COG4953	penicillin-binding protein 1C
FF125_21745	COG3279	Response regulator of the LytR AlgR family
FF125_21765	COG1381	Involved in DNA repair and RecF pathway recombination
FF125_21795	COG2884	Cell division ATP-binding protein ftsE