locus-tag	class	description
M673_00015	COG0592	DNA-directed DNA polymerase activity
M673_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M673_00030	COG0840	transmembrane signaling receptor activity
M673_00050	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M673_00060	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M673_00065	COG1522	sequence-specific DNA binding
M673_00070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M673_00075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_00080	COG3706	GGDEF domain
M673_00085	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
M673_00085	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M673_00090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M673_00095	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
M673_00100	COG2205	protein histidine kinase activity
M673_00105	COG3178	'Phosphotransferase
M673_00110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M673_00120	COG1074	ATP-dependent DNA helicase activity
M673_00155	COG0133	tryptophan synthase activity
M673_00190	COG0284	orotidine-5'-phosphate decarboxylase activity
M673_00195	COG3920	Histidine kinase
M673_00200	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M673_00200	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M673_00210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M673_00220	COG1393	Belongs to the ArsC family
M673_00245	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M673_00250	COG0443	Heat shock 70 kDa protein
M673_00260	COG0484	heat shock protein binding
M673_00265	COG3963	phosphatidate phosphatase activity
M673_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M673_00285	COG1028	Short-chain dehydrogenase reductase Sdr
M673_00290	COG4134	Bacterial extracellular solute-binding protein
M673_00305	COG1643	Atp-dependent helicase
M673_00315	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
M673_00325	COG0596	Alpha beta hydrolase
M673_00330	COG0667	Aldo Keto reductase
M673_00340	COG1185	polyribonucleotide nucleotidyltransferase activity
M673_00355	COG1785	Belongs to the alkaline phosphatase family
M673_00365	COG1136	(ABC) transporter
M673_00380	COG1028	Short-chain dehydrogenase reductase Sdr
M673_00400	COG0187	DNA topoisomerase II activity
M673_00405	COG0668	transmembrane transport
M673_00415	COG3706	GGDEF domain
M673_00420	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M673_00430	COG1280	lysine exporter protein (LysE YggA)
M673_00435	COG0756	dUTP diphosphatase activity
M673_00465	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M673_00470	COG1136	(ABC) transporter
M673_00475	COG0577	efflux transmembrane transporter activity
M673_00485	COG1234	tRNA 3'-trailer cleavage
M673_00500	COG1247	-acetyltransferase
M673_00505	COG0443	Heat shock 70 kDa protein
M673_00525	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M673_00530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M673_00535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M673_00540	COG1116	anion transmembrane transporter activity
M673_00545	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M673_00550	COG2146	nitrite reductase [NAD(P)H] activity
M673_00555	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
M673_00560	COG0243	molybdopterin cofactor binding
M673_00565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M673_00565	COG1648	precorrin-2 dehydrogenase activity
M673_00595	COG2201	protein-glutamate methylesterase activity
M673_00605	COG0835	chemotaxis
M673_00610	COG0835	chemotaxis
M673_00615	COG2198	Histidine kinase
M673_00615	COG0643	Histidine kinase
M673_00620	COG0745	RESPONSE REGULATOR receiver
M673_00630	COG0840	transmembrane signaling receptor activity
M673_00640	COG0745	RESPONSE REGULATOR receiver
M673_00645	COG0643	Histidine kinase
M673_00645	COG2198	Histidine kinase
M673_00650	COG0835	chemotaxis
M673_00655	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M673_00660	COG2201	protein-glutamate methylesterase activity
M673_00665	COG0745	RESPONSE REGULATOR receiver
M673_00670	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
M673_00685	COG1218	3'(2'),5'-bisphosphate nucleotidase
M673_00695	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M673_00700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M673_00705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M673_00710	COG0351	phosphomethylpyrimidine kinase
M673_00720	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M673_00725	COG4957	zinc ion binding
M673_00730	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
M673_00735	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M673_00745	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M673_00755	COG1968	undecaprenyl-diphosphatase activity
M673_00785	COG2855	membrane
M673_00795	COG0583	DNA-binding transcription factor activity
M673_00800	COG2515	1-aminocyclopropane-1-carboxylate deaminase
M673_00815	COG0747	negative chemotaxis
M673_00825	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_00830	COG1028	Short-chain dehydrogenase reductase Sdr
M673_00835	COG0444	Belongs to the ABC transporter superfamily
M673_00840	COG4608	Belongs to the ABC transporter superfamily
M673_00855	COG4948	Mandelate Racemase Muconate Lactonizing
M673_00860	COG1414	Transcriptional regulator
M673_00875	COG4948	Mandelate Racemase Muconate Lactonizing
M673_00880	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M673_00885	COG3964	amidohydrolase
M673_00905	COG0656	L-ascorbic acid biosynthetic process
M673_00910	COG3842	ATPase activity
M673_00930	COG4702	Belongs to the UPF0303 family
M673_00955	COG3920	Histidine kinase
M673_00955	COG2202	Pas domain
M673_00960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M673_00970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M673_00975	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M673_00980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M673_00980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M673_00995	COG0779	Required for maturation of 30S ribosomal subunits
M673_01000	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M673_01005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M673_01010	COG1396	sequence-specific DNA binding
M673_01025	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M673_01035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M673_01045	COG0456	acetyltransferase
M673_01055	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M673_01070	COG0180	Tryptophanyl-tRNA synthetase
M673_01080	COG0728	peptidoglycan biosynthetic process
M673_01085	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
M673_01090	COG1028	Short-chain dehydrogenase reductase Sdr
M673_01095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M673_01115	COG0604	alcohol dehydrogenase
M673_01125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M673_01126	COG0116	Belongs to the methyltransferase superfamily
M673_01126	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M673_01145	COG0616	signal peptide processing
M673_01160	COG1137	ATPase activity
M673_01170	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M673_01175	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M673_01185	COG0071	Belongs to the small heat shock protein (HSP20) family
M673_01190	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M673_01195	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M673_01215	COG0745	RESPONSE REGULATOR receiver
M673_01220	COG2205	protein histidine kinase activity
M673_01225	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M673_01250	COG1187	pseudouridine synthase activity
M673_01255	COG2391	methyltransferase activity
M673_01260	COG0481	GTPase activity
M673_01275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M673_01285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M673_01305	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M673_01310	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M673_01315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M673_01320	COG0799	negative regulation of ribosome biogenesis
M673_01325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M673_01335	COG0793	Belongs to the peptidase S41A family
M673_01360	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M673_01365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M673_01370	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M673_01375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M673_01400	COG0783	Belongs to the Dps family
M673_01405	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M673_01420	COG3309	Virulence-associated protein D
M673_01425	COG1053	succinate dehydrogenase
M673_01445	COG2199	diguanylate cyclase activity
M673_01475	COG0335	large ribosomal subunit rRNA binding
M673_01490	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M673_01495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M673_01505	COG0552	protein localization to endoplasmic reticulum
M673_01525	COG3118	belongs to the thioredoxin family
M673_01550	COG2814	Major facilitator Superfamily
M673_01555	COG0583	DNA-binding transcription factor activity
M673_01560	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
M673_01560	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
M673_01565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M673_01580	COG1175	transmembrane transport
M673_01585	COG3833	ABC-type maltose transport systems, permease component
M673_01590	COG3842	ATPase activity
M673_01610	COG1486	melibiose metabolic process
M673_01615	COG1609	Transcriptional regulator
M673_01615	COG2207	Transcriptional regulator
M673_01620	COG1486	melibiose metabolic process
M673_01625	COG0747	negative chemotaxis
M673_01630	COG0601	transmembrane transport
M673_01635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_01640	COG4172	Belongs to the ABC transporter superfamily
M673_01665	COG1028	Short-chain dehydrogenase reductase Sdr
M673_01670	COG0840	transmembrane signaling receptor activity
M673_01675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M673_01685	COG1120	ATPase activity
M673_01690	COG5001	Diguanylate cyclase
M673_01695	COG0326	Molecular chaperone. Has ATPase activity
M673_01700	COG1609	Transcriptional regulator
M673_01705	COG4774	siderophore transport
M673_01720	COG1175	transmembrane transport
M673_01725	COG3842	ATPase activity
M673_01750	COG1178	ABC-type Fe3 transport system permease component
M673_01755	COG3842	ATPase activity
M673_01765	COG0840	transmembrane signaling receptor activity
M673_01780	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M673_01785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M673_01790	COG0539	negative regulation of cytoplasmic translation
M673_01820	COG2885	chlorophyll binding
M673_01830	COG2814	Major facilitator Superfamily
M673_01835	COG1960	acyl-CoA dehydrogenase activity
M673_01840	COG3938	Belongs to the proline racemase family
M673_01850	COG3938	Belongs to the proline racemase family
M673_01855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_01880	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
M673_01885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M673_01890	COG1802	Transcriptional regulator
M673_01900	COG0318	PFAM AMP-dependent synthetase and ligase
M673_01905	COG1473	amidohydrolase
M673_01925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M673_01930	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M673_01940	COG0667	Aldo Keto reductase
M673_01960	COG0131	Imidazoleglycerol-phosphate dehydratase
M673_01970	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M673_01975	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M673_01985	COG0107	imidazoleglycerol-phosphate synthase activity
M673_02005	COG0596	Alpha beta hydrolase
M673_02010	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M673_02015	COG3706	GGDEF domain
M673_02025	COG3145	DNA-N1-methyladenine dioxygenase activity
M673_02030	COG2197	response regulator
M673_02035	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M673_02040	COG0477	Major facilitator Superfamily
M673_02045	COG0121	glutamine amidotransferase
M673_02050	COG1794	racemase activity, acting on amino acids and derivatives
M673_02055	COG1522	sequence-specific DNA binding
M673_02075	COG3800	Transcriptional regulator
M673_02075	COG1396	sequence-specific DNA binding
M673_02095	COG3030	protein affecting phage T7 exclusion by the F plasmid
M673_02100	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M673_02120	COG0237	dephospho-CoA kinase activity
M673_02135	COG0424	maF-like protein
M673_02140	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M673_02155	COG3265	gluconokinase activity
M673_02160	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M673_02175	COG1331	Highly conserved protein containing a thioredoxin domain
M673_02185	COG1695	Transcriptional regulator
M673_02190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M673_02195	COG1247	-acetyltransferase
M673_02205	COG0445	tRNA wobble uridine modification
M673_02215	COG1192	Involved in chromosome partitioning
M673_02220	COG1475	DNA binding
M673_02230	COG3755	Protein conserved in bacteria
M673_02245	COG0495	leucyl-tRNA aminoacylation
M673_02255	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M673_02260	COG0586	Pfam SNARE associated Golgi protein
M673_02270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M673_02275	COG3775	system Galactitol-specific IIC component
M673_02285	COG3414	Phosphotransferase system galactitol-specific IIB component
M673_02305	COG2814	Major facilitator Superfamily
M673_02315	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M673_02335	COG0501	Belongs to the peptidase M48B family
M673_02375	COG0138	bifunctional purine biosynthesis protein purh
M673_02390	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M673_02405	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
M673_02410	COG1704	LemA family
M673_02430	COG0288	reversible hydration of carbon dioxide
M673_02435	COG2845	Protein of unknown function (DUF459)
M673_02440	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
M673_02445	COG0045	succinate-CoA ligase (ADP-forming) activity
M673_02450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M673_02480	COG2203	Gaf domain
M673_02480	COG5001	Diguanylate cyclase
M673_02480	COG4251	negative regulation of phosphorylation
M673_02480	COG3706	GGDEF domain
M673_02500	COG1764	response to oxidative stress
M673_02510	COG1914	H( )-stimulated, divalent metal cation uptake system
M673_02515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M673_02520	COG0523	cobalamin synthesis protein
M673_02535	COG0473	3-isopropylmalate dehydrogenase activity
M673_02540	COG0840	transmembrane signaling receptor activity
M673_02550	COG0066	3-isopropylmalate dehydratase activity
M673_02555	COG1846	Transcriptional regulator
M673_02560	COG1764	response to oxidative stress
M673_02595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M673_02600	COG0587	DNA-directed DNA polymerase activity
M673_02605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M673_02625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M673_02650	COG2971	BadF BadG BcrA BcrD
M673_02665	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
M673_02670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M673_02675	COG2133	pyrroloquinoline quinone binding
M673_02680	COG1120	ATPase activity
M673_02690	COG4607	ABC-type enterochelin transport system periplasmic component
M673_02745	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
M673_02755	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M673_02760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M673_02765	COG0424	maF-like protein
M673_02770	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
M673_02800	COG2264	protein methyltransferase activity
M673_02820	COG2350	Protein conserved in bacteria
M673_02825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M673_02830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M673_02840	COG0181	hydroxymethylbilane synthase activity
M673_02870	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M673_02880	COG2851	Citrate transporter
M673_02890	COG0840	transmembrane signaling receptor activity
M673_02905	COG1872	DUF167
M673_02915	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M673_02930	COG0604	alcohol dehydrogenase
M673_02945	COG0339	signal peptide processing
M673_02955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M673_02960	COG0137	argininosuccinate synthase activity
M673_02965	COG0671	phosphoesterase, PA-phosphatase related
M673_03000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M673_03035	COG4181	ATPase activity
M673_03045	COG0670	Belongs to the BI1 family
M673_03055	COG5001	Diguanylate cyclase
M673_03055	COG3300	MHYT domain
M673_03070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M673_03075	COG4133	protoheme IX ABC transporter activity
M673_03080	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M673_03085	COG0456	acetyltransferase
M673_03085	COG0454	-acetyltransferase
M673_03090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M673_03100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M673_03110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M673_03120	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M673_03140	COG2895	sulfate adenylyltransferase (ATP) activity
M673_03145	COG0175	sulfate reduction
M673_03150	COG0175	sulfate reduction
M673_03160	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M673_03170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M673_03175	COG0745	RESPONSE REGULATOR receiver
M673_03175	COG3706	GGDEF domain
M673_03180	COG1946	Acyl-CoA thioesterase
M673_03185	COG0347	Belongs to the P(II) protein family
M673_03190	COG0004	ammonium transporteR
M673_03200	COG1674	ftsk spoiiie
M673_03210	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M673_03220	COG0740	serine-type endopeptidase activity
M673_03240	COG0596	Alpha beta hydrolase
M673_03250	COG4774	siderophore transport
M673_03260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M673_03270	COG2207	Transcriptional regulator
M673_03275	COG0667	Aldo Keto reductase
M673_03290	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M673_03295	COG1132	(ABC) transporter
M673_03300	COG0837	glucose binding
M673_03310	COG1268	BioY protein
M673_03315	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M673_03320	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
M673_03340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M673_03345	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M673_03350	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M673_03360	COG0243	molybdopterin cofactor binding
M673_03370	COG0745	RESPONSE REGULATOR receiver
M673_03385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M673_03395	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M673_03400	COG0606	chelatase, subunit chli
M673_03415	COG0189	ligase activity
M673_03425	COG0792	nuclease activity
M673_03430	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M673_03435	COG1742	UPF0060 membrane protein
M673_03440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M673_03445	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M673_03450	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M673_03480	COG1028	Short-chain dehydrogenase reductase Sdr
M673_03490	COG1252	NADH dehydrogenase
M673_03525	COG4191	Histidine kinase
M673_03525	COG0784	Response regulator, receiver
M673_03530	COG3920	Histidine kinase
M673_03530	COG2202	Pas domain
M673_03535	COG1028	Short-chain dehydrogenase reductase Sdr
M673_03545	COG1492	cobalamin metabolic process
M673_03585	COG2875	Belongs to the precorrin methyltransferase family
M673_03590	COG2099	Precorrin-6x reductase
M673_03595	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
M673_03600	COG1797	cobyrinic acid a,c-diamide synthase activity
M673_03655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M673_03680	COG5001	Diguanylate cyclase
M673_03680	COG3300	MHYT domain
M673_03695	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M673_03700	COG0583	DNA-binding transcription factor activity
M673_03745	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M673_03750	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M673_03755	COG2080	2 iron, 2 sulfur cluster binding
M673_03775	COG0673	inositol 2-dehydrogenase activity
M673_03780	COG1129	ABC transporter
M673_03785	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_03790	COG1879	ABC-type sugar transport system periplasmic component
M673_03795	COG0328	RNA-DNA hybrid ribonuclease activity
M673_03805	COG1028	Short-chain dehydrogenase reductase Sdr
M673_03835	COG0583	DNA-binding transcription factor activity
M673_03840	COG1733	regulation of RNA biosynthetic process
M673_03880	COG3237	CsbD-like
M673_03885	COG0784	Response regulator, receiver
M673_03885	COG4191	Histidine kinase
M673_03900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M673_03905	COG0747	negative chemotaxis
M673_03910	COG0601	transmembrane transport
M673_03930	COG2205	protein histidine kinase activity
M673_03935	COG0745	RESPONSE REGULATOR receiver
M673_03945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M673_03953	COG0583	DNA-binding transcription factor activity
M673_03985	COG1028	Short-chain dehydrogenase reductase Sdr
M673_04020	COG3293	Transposase
M673_04035	COG1136	(ABC) transporter
M673_04060	COG0745	RESPONSE REGULATOR receiver
M673_04065	COG0642	Histidine kinase
M673_04085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_04095	COG1162	GTPase activity
M673_04130	COG1454	alcohol dehydrogenase
M673_04135	COG1012	belongs to the aldehyde dehydrogenase family
M673_04140	COG0583	DNA-binding transcription factor activity
M673_04150	COG2301	Belongs to the HpcH HpaI aldolase family
M673_04160	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M673_04170	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M673_04190	COG0745	RESPONSE REGULATOR receiver
M673_04215	COG2814	Major facilitator Superfamily
M673_04235	COG1309	transcriptional regulator
M673_04265	COG2207	Transcriptional regulator
M673_04290	COG0765	amino acid transport
M673_04300	COG1126	abc transporter atp-binding protein
M673_04305	COG4948	Mandelate Racemase Muconate Lactonizing
M673_04320	COG1063	alcohol dehydrogenase
M673_04335	COG2207	Transcriptional regulator
M673_04350	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M673_04365	COG2900	Belongs to the SlyX family
M673_04405	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M673_04410	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M673_04420	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M673_04425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
M673_04430	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M673_04465	COG4964	Belongs to the GSP D family
M673_04500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M673_04520	COG0494	nUDIX hydrolase
M673_04525	COG4172	Belongs to the ABC transporter superfamily
M673_04545	COG4239	(ABC) transporter, permease
M673_04550	COG4174	ABC transporter (Permease)
M673_04555	COG4166	transmembrane transport
M673_04560	COG4166	transmembrane transport
M673_04565	COG3474	cytochrome
M673_04570	COG0077	Prephenate dehydratase
M673_04570	COG1605	Chorismate mutase
M673_04595	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M673_04605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M673_04645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M673_04655	COG0242	peptide deformylase activity
M673_04660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M673_04665	COG0101	tRNA pseudouridine synthase activity
M673_04675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M673_04690	COG2171	N-acyltransferase activity
M673_04715	COG0477	Major facilitator Superfamily
M673_04720	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M673_04725	COG0784	Response regulator, receiver
M673_04725	COG4191	Histidine kinase
M673_04735	COG1028	Short-chain dehydrogenase reductase Sdr
M673_04755	COG0840	transmembrane signaling receptor activity
M673_04760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M673_04790	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M673_04805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M673_04815	COG0336	Belongs to the RNA methyltransferase TrmD family
M673_04835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M673_04850	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M673_04865	COG2943	transferase activity, transferring hexosyl groups
M673_04875	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
M673_04900	COG1139	Iron-sulfur cluster binding protein
M673_04905	COG0247	lactate metabolic process
M673_04915	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
M673_04920	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
M673_04935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M673_04950	COG3206	protein involved in exopolysaccharide biosynthesis
M673_04950	COG0489	protein tyrosine kinase activity
M673_04995	COG1215	transferase activity, transferring glycosyl groups
M673_05035	COG3158	transport of potassium into the cell
M673_05050	COG2113	Glycine betaine
M673_05060	COG4175	Glycine betaine
M673_05060	COG0517	IMP dehydrogenase activity
M673_05070	COG0438	transferase activity, transferring glycosyl groups
M673_05080	COG2814	Major facilitator Superfamily
M673_05085	COG2329	Antibiotic biosynthesis monooxygenase
M673_05110	COG0601	transmembrane transport
M673_05115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_05125	COG4608	Belongs to the ABC transporter superfamily
M673_05160	COG0330	HflC and HflK could
M673_05165	COG0737	Belongs to the 5'-nucleotidase family
M673_05170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
M673_05185	COG1376	ErfK ybiS ycfS ynhG family protein
M673_05195	COG0824	Thioesterase
M673_05200	COG5001	Diguanylate cyclase
M673_05200	COG3300	MHYT domain
M673_05210	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M673_05220	COG3781	membrane
M673_05230	COG3750	Belongs to the UPF0335 family
M673_05245	COG0300	oxidoreductase activity
M673_05255	COG1295	ribonuclease BN
M673_05270	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M673_05285	COG1522	sequence-specific DNA binding
M673_05305	COG0829	nickel cation binding
M673_05310	COG0831	urea catabolic process
M673_05325	COG0832	Belongs to the urease beta subunit family
M673_05340	COG0804	urea catabolic process
M673_05345	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
M673_05350	COG0830	nickel cation binding
M673_05355	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
M673_05365	COG2824	Alkylphosphonate utilization operon protein PhnA
M673_05370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M673_05375	COG2226	methyltransferase
M673_05380	COG4993	Dehydrogenase
M673_05405	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M673_05440	COG0402	S-adenosylhomocysteine deaminase activity
M673_05445	COG0179	Fumarylacetoacetate (FAA) hydrolase
M673_05450	COG0366	Alpha amylase catalytic
M673_05455	COG3281	Trehalose synthase
M673_05465	COG0745	RESPONSE REGULATOR receiver
M673_05465	COG3706	GGDEF domain
M673_05490	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
M673_05495	COG1640	4-alpha-glucanotransferase
M673_05510	COG0673	inositol 2-dehydrogenase activity
M673_05545	COG0739	heme binding
M673_05545	COG0741	lytic transglycosylase activity
M673_05545	COG1196	nuclear chromosome segregation
M673_05560	COG2378	regulation of single-species biofilm formation
M673_05565	COG0142	geranyltranstransferase activity
M673_05570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M673_05575	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M673_05585	COG0183	Belongs to the thiolase family
M673_05625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M673_05635	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
M673_05665	COG2273	Hydrolase Family 16
M673_05665	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
M673_05695	COG2226	methyltransferase
M673_05750	COG1028	Short-chain dehydrogenase reductase Sdr
M673_05755	COG1247	-acetyltransferase
M673_05760	COG1982	Orn Lys Arg decarboxylase major
M673_05775	COG3842	ATPase activity
M673_05815	COG2273	Hydrolase Family 16
M673_05815	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
M673_05820	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M673_05825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M673_05830	COG3206	protein involved in exopolysaccharide biosynthesis
M673_05830	COG0489	protein tyrosine kinase activity
M673_05865	COG1216	Glycosyl transferase, family 2
M673_05865	COG0463	Glycosyl transferase, family 2
M673_05870	COG2244	polysaccharide biosynthetic process
M673_05875	COG0463	Glycosyl transferase, family 2
M673_05890	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M673_05900	COG1012	belongs to the aldehyde dehydrogenase family
M673_05905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_05910	COG5383	Protein conserved in bacteria
M673_05915	COG1028	Short-chain dehydrogenase reductase Sdr
M673_05945	COG1733	regulation of RNA biosynthetic process
M673_05960	COG1028	Short-chain dehydrogenase reductase Sdr
M673_05975	COG0300	oxidoreductase activity
M673_06010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M673_06045	COG3973	AAA domain
M673_06110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M673_06160	COG3852	Histidine kinase
M673_06165	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M673_06170	COG0594	ribonuclease P activity
M673_06180	COG0110	maltose O-acetyltransferase activity
M673_06185	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M673_06190	COG1051	belongs to the nudix hydrolase family
M673_06195	COG1309	transcriptional regulator
M673_06210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M673_06215	COG5328	Belongs to the UPF0262 family
M673_06220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M673_06250	COG3206	protein involved in exopolysaccharide biosynthesis
M673_06250	COG0489	protein tyrosine kinase activity
M673_06255	COG1653	transport
M673_06270	COG3842	ATPase activity
M673_06280	COG0129	dihydroxy-acid dehydratase activity
M673_06285	COG0363	glucosamine-6-phosphate deaminase activity
M673_06290	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M673_06295	COG4251	negative regulation of phosphorylation
M673_06305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_06310	COG0174	glutamine synthetase
M673_06330	COG3842	ATPase activity
M673_06335	COG1176	ABC-type spermidine putrescine transport system, permease component I
M673_06340	COG1177	transmembrane transport
M673_06355	COG2205	protein histidine kinase activity
M673_06375	COG0025	NhaP-type Na H and K H
M673_06380	COG1570	exodeoxyribonuclease VII activity
M673_06385	COG0583	DNA-binding transcription factor activity
M673_06395	COG1253	flavin adenine dinucleotide binding
M673_06425	COG0277	FAD linked oxidase domain protein
M673_06435	COG0247	lactate metabolic process
M673_06445	COG1376	ErfK ybiS ycfS ynhG family protein
M673_06445	COG1388	LysM domain
M673_06450	COG1376	ErfK ybiS ycfS ynhG family protein
M673_06460	COG2818	Glycosylase
M673_06465	COG0124	histidyl-tRNA synthetase
M673_06470	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M673_06475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M673_06480	COG2259	Doxx family
M673_06485	COG0114	fumarate hydratase activity
M673_06495	COG0730	response to heat
M673_06500	COG0459	protein refolding
M673_06520	COG0196	riboflavin kinase activity
M673_06525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M673_06535	COG0590	tRNA wobble adenosine to inosine editing
M673_06540	COG1187	pseudouridine synthase activity
M673_06545	COG0742	ribosomal rna small subunit methyltransferase
M673_06550	COG0612	Peptidase, M16
M673_06555	COG0612	Peptidase, M16
M673_06560	COG1752	Esterase of the alpha-beta hydrolase superfamily
M673_06575	COG0312	modulator of DNA gyrase
M673_06595	COG1519	Transferase
M673_06600	COG1663	tetraacyldisaccharide 4'-kinase activity
M673_06625	COG0033	Phosphoglucomutase
M673_06630	COG0297	glycogen (starch) synthase activity
M673_06635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
M673_06640	COG0058	SHG alpha-glucan phosphorylase activity
M673_06645	COG0166	Belongs to the GPI family
M673_06660	COG0729	surface antigen
M673_06695	COG1396	sequence-specific DNA binding
M673_06700	COG1473	amidohydrolase
M673_06705	COG1686	Belongs to the peptidase S11 family
M673_06710	COG0523	cobalamin synthesis protein
M673_06715	COG0425	Belongs to the sulfur carrier protein TusA family
M673_06730	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M673_06740	COG0678	peroxiredoxin activity
M673_06755	COG0583	DNA-binding transcription factor activity
M673_06760	COG2514	catechol 2,3-dioxygenase activity
M673_06765	COG0435	Glutathione S-transferase
M673_06770	COG0252	asparaginase activity
M673_06775	COG3720	iron ion transport
M673_06780	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
M673_06785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M673_06790	COG4558	Periplasmic binding protein
M673_06800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M673_06805	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M673_06810	COG1063	alcohol dehydrogenase
M673_06820	COG1129	ABC transporter
M673_06825	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_06840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M673_06845	COG0022	dehydrogenase e1 component
M673_06845	COG0508	dehydrogenase complex catalyzes the overall conversion of
M673_06850	COG0508	dehydrogenase complex catalyzes the overall conversion of
M673_06855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M673_06860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M673_06870	COG3732	PTS system glucitol sorbitol-specific
M673_06910	COG1129	ABC transporter
M673_06915	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_06940	COG2376	Dihydroxyacetone kinase
M673_06950	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M673_06955	COG1802	Transcriptional regulator
M673_06960	COG2376	Dihydroxyacetone kinase
M673_06975	COG0840	transmembrane signaling receptor activity
M673_07020	COG0747	negative chemotaxis
M673_07025	COG0601	transmembrane transport
M673_07035	COG0444	Belongs to the ABC transporter superfamily
M673_07045	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M673_07050	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M673_07055	COG2080	2 iron, 2 sulfur cluster binding
M673_07060	COG0784	Response regulator, receiver
M673_07060	COG4191	Histidine kinase
M673_07070	COG2207	Transcriptional regulator
M673_07075	COG1733	regulation of RNA biosynthetic process
M673_07080	COG0702	epimerase
M673_07085	COG0415	Belongs to the DNA photolyase family
M673_07090	COG2066	Belongs to the glutaminase family
M673_07105	COG2273	Hydrolase Family 16
M673_07105	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
M673_07110	COG5001	Diguanylate cyclase
M673_07115	COG4521	taurine ABC transporter
M673_07120	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
M673_07125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M673_07145	COG0626	cystathionine gamma-synthase activity
M673_07155	COG1187	pseudouridine synthase activity
M673_07170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M673_07175	COG4172	Belongs to the ABC transporter superfamily
M673_07185	COG0601	transmembrane transport
M673_07190	COG0747	negative chemotaxis
M673_07200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M673_07245	COG1174	glycine betaine transport
M673_07250	COG1125	glycine betaine transport
M673_07255	COG1174	glycine betaine transport
M673_07280	COG3119	arylsulfatase activity
M673_07295	COG1877	trehalose-phosphatase activity
M673_07300	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
M673_07305	COG0800	Aldolase
M673_07330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M673_07335	COG1609	Transcriptional regulator
M673_07350	COG0523	cobalamin synthesis protein
M673_07360	COG3153	acetyltransferase
M673_07370	COG0583	DNA-binding transcription factor activity
M673_07385	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
M673_07390	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M673_07405	COG0693	protein deglycase activity
M673_07425	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M673_07445	COG1830	Aldolase
M673_07455	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M673_07485	COG0346	lactoylglutathione lyase activity
M673_07490	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M673_07500	COG2183	response to ionizing radiation
M673_07505	COG3257	ureidoglycine aminohydrolase activity
M673_07515	COG0840	transmembrane signaling receptor activity
M673_07520	COG3237	CsbD-like
M673_07535	COG0640	Transcriptional regulator
M673_07585	COG0243	molybdopterin cofactor binding
M673_07605	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M673_07610	COG0477	Major facilitator Superfamily
M673_07635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M673_07640	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
M673_07645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M673_07655	COG0519	Catalyzes the synthesis of GMP from XMP
M673_07655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M673_07660	COG0583	DNA-binding transcription factor activity
M673_07695	COG0483	inositol monophosphate 1-phosphatase activity
M673_07710	COG0071	Belongs to the small heat shock protein (HSP20) family
M673_07725	COG0067	glutamate synthase
M673_07725	COG0069	glutamate synthase activity
M673_07725	COG0070	glutamate synthase
M673_07745	COG2951	lytic endotransglycosylase activity
M673_07750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M673_07765	COG3920	Histidine kinase
M673_07765	COG2202	Pas domain
M673_07780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M673_07785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M673_07820	COG0437	4 iron, 4 sulfur cluster binding
M673_07850	COG0673	inositol 2-dehydrogenase activity
M673_07855	COG0395	ABC-type sugar transport system, permease component
M673_07860	COG1175	transmembrane transport
M673_07870	COG1309	transcriptional regulator
M673_07875	COG0673	inositol 2-dehydrogenase activity
M673_07890	COG0673	inositol 2-dehydrogenase activity
M673_07895	COG0400	carboxylic ester hydrolase activity
M673_07900	COG0346	lactoylglutathione lyase activity
M673_07910	COG3842	ATPase activity
M673_07915	COG0395	ABC-type sugar transport system, permease component
M673_07920	COG1175	transmembrane transport
M673_07925	COG1653	transport
M673_07930	COG0584	glycerophosphoryl diester phosphodiesterase
M673_07935	COG0483	inositol monophosphate 1-phosphatase activity
M673_07940	COG0473	3-isopropylmalate dehydrogenase activity
M673_07955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_07960	COG0601	transmembrane transport
M673_07975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_07980	COG2186	Transcriptional regulator
M673_07990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_08015	COG1012	belongs to the aldehyde dehydrogenase family
M673_08020	COG1012	belongs to the aldehyde dehydrogenase family
M673_08025	COG0456	acetyltransferase
M673_08030	COG1522	sequence-specific DNA binding
M673_08035	COG5001	Diguanylate cyclase
M673_08040	COG0598	Magnesium transport protein CorA
M673_08050	COG1376	ErfK ybiS ycfS ynhG family protein
M673_08055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M673_08060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M673_08070	COG2010	Cytochrome c
M673_08080	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M673_08095	COG1006	Multisubunit Na H antiporter MnhC subunit
M673_08105	COG1863	multisubunit Na H antiporter MnhE subunit
M673_08110	COG2212	antiporter activity
M673_08115	COG1320	monovalent cation:proton antiporter activity
M673_08130	COG0392	lysyltransferase activity
M673_08130	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M673_08135	COG0493	'glutamate synthase
M673_08145	COG5001	Diguanylate cyclase
M673_08150	COG1309	transcriptional regulator
M673_08165	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M673_08170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M673_08185	COG1597	lipid kinase activity
M673_08220	COG0784	Response regulator, receiver
M673_08225	COG2202	Pas domain
M673_08225	COG3920	Histidine kinase
M673_08255	COG0747	negative chemotaxis
M673_08260	COG0601	transmembrane transport
M673_08265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_08270	COG0444	Belongs to the ABC transporter superfamily
M673_08275	COG4608	Belongs to the ABC transporter superfamily
M673_08280	COG1522	sequence-specific DNA binding
M673_08285	COG0506	proline dehydrogenase activity
M673_08285	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M673_08285	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
M673_08290	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M673_08305	COG0512	Glutamine amidotransferase of anthranilate synthase
M673_08305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M673_08310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M673_08325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M673_08335	COG3135	benzoate transporter
M673_08345	COG0494	nUDIX hydrolase
M673_08350	COG0435	Glutathione S-transferase
M673_08380	COG0714	Associated with various cellular activities
M673_08395	COG0617	tRNA 3'-terminal CCA addition
M673_08405	COG0408	coproporphyrinogen oxidase activity
M673_08415	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M673_08420	COG1132	(ABC) transporter
M673_08425	COG1132	(ABC) transporter
M673_08440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M673_08440	COG2857	Cytochrome c1
M673_08460	COG0012	GTP binding
M673_08465	COG0193	aminoacyl-tRNA hydrolase activity
M673_08470	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M673_08480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M673_08485	COG0006	proline dipeptidase activity
M673_08500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M673_08520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M673_08525	COG2205	protein histidine kinase activity
M673_08530	COG0745	RESPONSE REGULATOR receiver
M673_08535	COG1846	Transcriptional regulator
M673_08540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M673_08545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M673_08550	COG1278	Cold shock
M673_08570	COG1464	Belongs to the NlpA lipoprotein family
M673_08575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M673_08580	COG2011	ABC-type metal ion transport system permease component
M673_08585	COG0670	Belongs to the BI1 family
M673_08613	COG1078	dGTPase activity
M673_08615	COG0556	nucleotide-excision repair
M673_08625	COG1607	acyl-coa hydrolase
M673_08630	COG2032	superoxide dismutase activity
M673_08640	COG0625	glutathione transferase activity
M673_08650	COG0583	DNA-binding transcription factor activity
M673_08655	COG0492	ferredoxin-NADP+ reductase activity
M673_08660	COG5265	(ABC) transporter
M673_08665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M673_08675	COG0438	transferase activity, transferring glycosyl groups
M673_08690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M673_08710	COG0505	Belongs to the CarA family
M673_08720	COG0287	Prephenate dehydrogenase
M673_08720	COG1605	Chorismate mutase
M673_08730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M673_08750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M673_08760	COG1126	abc transporter atp-binding protein
M673_08765	COG3706	GGDEF domain
M673_08780	COG2202	Pas domain
M673_08780	COG3920	Histidine kinase
M673_08785	COG4191	Histidine kinase
M673_08785	COG0784	Response regulator, receiver
M673_08815	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
M673_08820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M673_08835	COG0477	Major facilitator Superfamily
M673_08840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M673_08845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M673_08850	COG1845	cytochrome c oxidase, subunit III
M673_08855	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M673_08880	COG1850	ribulose-bisphosphate carboxylase activity
M673_08895	COG0673	inositol 2-dehydrogenase activity
M673_08900	COG0287	Prephenate dehydrogenase
M673_08910	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M673_08915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M673_08925	COG2186	Transcriptional regulator
M673_08935	COG0840	transmembrane signaling receptor activity
M673_08935	COG3290	protein histidine kinase activity
M673_08940	COG3386	PFAM SMP-30 Gluconolaconase
M673_08960	COG3206	protein involved in exopolysaccharide biosynthesis
M673_08960	COG0489	protein tyrosine kinase activity
M673_08985	COG2244	polysaccharide biosynthetic process
M673_09000	COG0297	glycogen (starch) synthase activity
M673_09030	COG1793	dna ligase
M673_09040	COG0123	including yeast histone deacetylase and acetoin utilization protein
M673_09055	COG0432	Pfam Uncharacterised protein family UPF0047
M673_09060	COG1970	mechanosensitive ion channel activity
M673_09075	COG0156	8-amino-7-oxononanoate synthase activity
M673_09090	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M673_09100	COG0747	negative chemotaxis
M673_09110	COG1132	(ABC) transporter
M673_09115	COG3300	MHYT domain
M673_09115	COG5001	Diguanylate cyclase
M673_09120	COG4774	siderophore transport
M673_09125	COG0039	L-malate dehydrogenase activity
M673_09135	COG0300	oxidoreductase activity
M673_09140	COG1686	Belongs to the peptidase S11 family
M673_09145	COG1028	Short-chain dehydrogenase reductase Sdr
M673_09150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M673_09170	COG0671	phosphoesterase, PA-phosphatase related
M673_09180	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_09185	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_09190	COG1129	ABC transporter
M673_09195	COG1028	Short-chain dehydrogenase reductase Sdr
M673_09200	COG1063	alcohol dehydrogenase
M673_09215	COG3254	rhamnose metabolic process
M673_09220	COG1349	DNA-binding transcription factor activity
M673_09225	COG1028	Short-chain dehydrogenase reductase Sdr
M673_09225	COG3347	Dehydrogenase
M673_09230	COG4952	isomerase
M673_09255	COG0534	Mate efflux family protein
M673_09270	COG2017	converts alpha-aldose to the beta-anomer
M673_09275	COG0129	dihydroxy-acid dehydratase activity
M673_09280	COG3386	PFAM SMP-30 Gluconolaconase
M673_09285	COG3734	2-keto-3-deoxy-galactonokinase
M673_09290	COG0800	Aldolase
M673_09295	COG4213	ABC transporter substrate-binding protein
M673_09300	COG4213	ABC transporter substrate-binding protein
M673_09310	COG4214	carbohydrate transport
M673_09335	COG1012	belongs to the aldehyde dehydrogenase family
M673_09355	COG0247	lactate metabolic process
M673_09355	COG2181	nitrate reductase activity
M673_09360	COG1902	pentaerythritol trinitrate reductase activity
M673_09360	COG0446	pyridine nucleotide-disulphide oxidoreductase
M673_09370	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M673_09370	COG1017	nitric oxide dioxygenase activity
M673_09385	COG0446	pyridine nucleotide-disulphide oxidoreductase
M673_09385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M673_09395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_09405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M673_09405	COG4651	solute:proton antiporter activity
M673_09420	COG2022	thiamine diphosphate biosynthetic process
M673_09435	COG2267	carboxylic ester hydrolase activity
M673_09460	COG0784	Response regulator, receiver
M673_09465	COG0586	Pfam SNARE associated Golgi protein
M673_09480	COG1720	tRNA m6t6A37 methyltransferase activity
M673_09485	COG0640	Transcriptional regulator
M673_09515	COG2321	neutral zinc metallopeptidase
M673_09520	COG0751	glycine-tRNA ligase activity
M673_09525	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M673_09540	COG0009	L-threonylcarbamoyladenylate synthase
M673_09560	COG0151	Belongs to the GarS family
M673_09565	COG1960	acyl-CoA dehydrogenase activity
M673_09570	COG0183	Belongs to the thiolase family
M673_09575	COG1024	Enoyl-CoA hydratase
M673_09575	COG1250	3-hydroxyacyl-CoA dehydrogenase
M673_09585	COG1960	acyl-CoA dehydrogenase activity
M673_09590	COG1024	Enoyl-CoA hydratase
M673_09600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M673_09610	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M673_09615	COG1722	exodeoxyribonuclease VII activity
M673_09620	COG0123	including yeast histone deacetylase and acetoin utilization protein
M673_09635	COG0406	alpha-ribazole phosphatase activity
M673_09640	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M673_09645	COG0484	heat shock protein binding
M673_09655	COG0259	pyridoxamine-phosphate oxidase activity
M673_09660	COG0312	modulator of DNA gyrase
M673_09670	COG1565	acr, cog1565
M673_09670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M673_09675	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M673_09680	COG0109	protoheme IX farnesyltransferase activity
M673_09690	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M673_09705	COG3346	SURF1 family
M673_09710	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M673_09715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M673_09720	COG0328	RNA-DNA hybrid ribonuclease activity
M673_09735	COG1678	Uncharacterized ACR, COG1678
M673_09750	COG0612	Peptidase, M16
M673_09765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M673_09770	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M673_09795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M673_09800	COG0574	Belongs to the PEP-utilizing enzyme family
M673_09800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M673_09810	COG0318	PFAM AMP-dependent synthetase and ligase
M673_09820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M673_09835	COG0803	Belongs to the bacterial solute-binding protein 9 family
M673_09865	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M673_09875	COG4208	sulfate ABC transporter
M673_09880	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M673_09895	COG5002	protein histidine kinase activity
M673_09895	COG0784	Response regulator, receiver
M673_09895	COG2198	Histidine kinase
M673_09905	COG0559	Belongs to the binding-protein-dependent transport system permease family
M673_09915	COG0411	ABC transporter
M673_09925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M673_09935	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M673_09940	COG0668	transmembrane transport
M673_09970	COG0656	L-ascorbic acid biosynthetic process
M673_09985	COG1522	sequence-specific DNA binding
M673_10000	COG1960	acyl-CoA dehydrogenase activity
M673_10005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M673_10020	COG1024	Enoyl-CoA hydratase
M673_10025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M673_10030	COG1285	pathogenesis
M673_10050	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
M673_10070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M673_10125	COG3293	Transposase
M673_10150	COG0028	Belongs to the TPP enzyme family
M673_10160	COG1215	transferase activity, transferring glycosyl groups
M673_10170	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M673_10190	COG1309	transcriptional regulator
M673_10200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M673_10225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M673_10240	COG0546	phosphoglycolate phosphatase activity
M673_10245	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
M673_10265	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
M673_10280	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M673_10280	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
M673_10285	COG0281	malic enzyme
M673_10285	COG0280	phosphate acetyltransferase
M673_10295	COG2814	Major facilitator Superfamily
M673_10300	COG4948	Mandelate Racemase Muconate Lactonizing
M673_10305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M673_10310	COG1127	ABC transporter
M673_10320	COG3218	ABC-type transport auxiliary lipoprotein component
M673_10320	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
M673_10340	COG0633	Ferredoxin
M673_10350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M673_10355	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M673_10365	COG3768	UPF0283 membrane protein
M673_10370	COG3106	COG3106 Predicted ATPase
M673_10375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M673_10395	COG2313	pseudouridylate synthase activity
M673_10400	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
M673_10400	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M673_10410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M673_10425	COG0538	isocitrate dehydrogenase activity
M673_10430	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
M673_10435	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M673_10450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M673_10455	COG0037	tRNA processing
M673_10460	COG0483	inositol monophosphate 1-phosphatase activity
M673_10465	COG2814	Major facilitator Superfamily
M673_10470	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M673_10480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M673_10495	COG0047	phosphoribosylformylglycinamidine synthase activity
M673_10500	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M673_10505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M673_10520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M673_10530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M673_10535	COG3191	aminopeptidase activity
M673_10565	COG0410	ABC transporter
M673_10575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M673_10595	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
M673_10595	COG3608	succinylglutamate desuccinylase aspartoacylase
M673_10600	COG2068	MobA-Related Protein
M673_10610	COG2003	Belongs to the UPF0758 family
M673_10615	COG0024	Methionine aminopeptidase
M673_10620	COG3243	poly(R)-hydroxyalkanoic acid synthase
M673_10630	COG0436	Aminotransferase
M673_10640	COG1494	fructose-1,6-bisphosphatase
M673_10645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M673_10730	COG1278	Cold shock
M673_10765	COG0626	cystathionine gamma-synthase activity
M673_10770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M673_10775	COG4597	amino acid ABC transporter
M673_10780	COG0765	amino acid transport
M673_10785	COG1126	abc transporter atp-binding protein
M673_10790	COG0628	permease
M673_10795	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M673_10795	COG2885	chlorophyll binding
M673_10815	COG0596	Alpha beta hydrolase
M673_10845	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M673_10850	COG1752	Esterase of the alpha-beta hydrolase superfamily
M673_10855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M673_10860	COG0302	gtp cyclohydrolase
M673_10875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M673_10890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M673_10900	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M673_10905	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M673_10930	COG0785	Cytochrome C biogenesis protein
M673_10935	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M673_10940	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M673_10955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M673_10960	COG4166	transmembrane transport
M673_10975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M673_10980	COG1183	phosphatidylcholine synthase activity
M673_11000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M673_11015	COG0656	L-ascorbic acid biosynthetic process
M673_11020	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M673_11045	COG1686	Belongs to the peptidase S11 family
M673_11055	COG0463	Glycosyl transferase, family 2
M673_11070	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
M673_11090	COG0537	adenosine 5'-monophosphoramidase activity
M673_11115	COG0052	Belongs to the universal ribosomal protein uS2 family
M673_11120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M673_11125	COG0528	UMP kinase activity
M673_11130	COG0233	cytoplasmic translational termination
M673_11135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M673_11140	COG0575	Belongs to the CDS family
M673_11145	COG0750	zinc metalloprotease
M673_11150	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M673_11155	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M673_11160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M673_11165	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M673_11175	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M673_11180	COG0372	Belongs to the citrate synthase family
M673_11190	COG2333	competence protein COMEC
M673_11190	COG0658	competence protein
M673_11195	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M673_11200	COG0303	'Molybdopterin
M673_11205	COG0315	cyclic pyranopterin monophosphate synthase activity
M673_11210	COG0134	indole-3-glycerol-phosphate synthase activity
M673_11215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
M673_11225	COG0149	triose-phosphate isomerase activity
M673_11235	COG0504	CTP synthase activity
M673_11245	COG0148	phosphopyruvate hydratase activity
M673_11250	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M673_11255	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M673_11260	COG0022	dehydrogenase e1 component
M673_11260	COG0508	dehydrogenase complex catalyzes the overall conversion of
M673_11265	COG0508	dehydrogenase complex catalyzes the overall conversion of
M673_11275	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M673_11290	COG2867	negative regulation of translational initiation
M673_11295	COG1546	Belongs to the CinA family
M673_11300	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M673_11300	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M673_11310	COG3852	Histidine kinase
M673_11315	COG2204	response regulator
M673_11320	COG5000	phosphorelay sensor kinase activity
M673_11325	COG2204	response regulator
M673_11330	COG0569	domain protein
M673_11340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M673_11345	COG3956	TIGRFAM MazG family protein
M673_11350	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M673_11350	COG0321	lipoyl(octanoyl) transferase activity
M673_11355	COG0084	hydrolase, TatD family'
M673_11370	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M673_11375	COG1686	Belongs to the peptidase S11 family
M673_11385	COG0343	queuine tRNA-ribosyltransferase activity
M673_11390	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M673_11395	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M673_11400	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M673_11405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M673_11415	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M673_11420	COG2095	MarC family integral membrane protein
M673_11430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M673_11435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
M673_11435	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
M673_11440	COG0347	Belongs to the P(II) protein family
M673_11445	COG0174	glutamine synthetase
M673_11455	COG0187	DNA topoisomerase II activity
M673_11475	COG2151	metal-sulfur cluster biosynthetic enzyme
M673_11480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M673_11485	COG0719	Fe-S assembly protein
M673_11490	COG0396	ATPase activity
M673_11495	COG0719	Fe-S assembly protein
M673_11505	COG2945	thiolester hydrolase activity
M673_11510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M673_11520	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M673_11525	COG2833	Protein of unknown function (DUF455)
M673_11530	COG0741	lytic transglycosylase activity
M673_11530	COG1196	nuclear chromosome segregation
M673_11530	COG0739	heme binding
M673_11545	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M673_11550	COG0860	N-Acetylmuramoyl-L-alanine amidase
M673_11550	COG1388	LysM domain
M673_11555	COG1530	ribonuclease E activity
M673_11560	COG0436	Aminotransferase
M673_11575	COG0511	ligase activity, forming carbon-carbon bonds
M673_11580	COG0439	Biotin carboxylase
M673_11585	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
M673_11590	COG4765	Protein conserved in bacteria
M673_11600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M673_11615	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M673_11620	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M673_11625	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M673_11645	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M673_11650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M673_11655	COG0758	DNA mediated transformation
M673_11660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M673_11665	COG0557	exoribonuclease II activity
M673_11675	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M673_11680	COG0745	RESPONSE REGULATOR receiver
M673_11680	COG3706	GGDEF domain
M673_11700	COG0587	DNA-directed DNA polymerase activity
M673_11720	COG1136	(ABC) transporter
M673_11730	COG0442	prolyl-tRNA aminoacylation
M673_11750	COG1007	ATP synthesis coupled electron transport
M673_11765	COG0713	ATP synthesis coupled electron transport
M673_11775	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M673_11780	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M673_11790	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M673_11795	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M673_11800	COG0649	NAD binding
M673_11810	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M673_11815	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M673_11820	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M673_11840	COG0776	regulation of translation
M673_11845	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M673_11850	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M673_11855	COG0740	serine-type endopeptidase activity
M673_11860	COG0544	peptidyl-prolyl cis-trans isomerase activity
M673_11875	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M673_11910	COG0739	heme binding
M673_11910	COG1388	LysM domain
M673_11915	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M673_11920	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
M673_11930	COG0805	protein transport
M673_11935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M673_11940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M673_11945	COG1472	Belongs to the glycosyl hydrolase 3 family
M673_11955	COG0018	arginyl-trna synthetase
M673_11965	COG0316	Belongs to the HesB IscA family
M673_11975	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
M673_12000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
M673_12020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M673_12030	COG2897	thiosulfate sulfurtransferase activity
M673_12040	COG0737	Belongs to the 5'-nucleotidase family
M673_12050	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M673_12055	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M673_12070	COG0655	NAD(P)H dehydrogenase (quinone) activity
M673_12075	COG1546	Belongs to the CinA family
M673_12075	COG1058	Belongs to the CinA family
M673_12080	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
M673_12085	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M673_12105	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_12125	COG1760	l-serine dehydratase
M673_12150	COG0625	glutathione transferase activity
M673_12155	COG3739	integral membrane protein
M673_12170	COG3842	ATPase activity
M673_12180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_12190	COG1176	ABC-type spermidine putrescine transport system, permease component I
M673_12205	COG1028	Short-chain dehydrogenase reductase Sdr
M673_12220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M673_12230	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M673_12260	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
M673_12265	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
M673_12270	COG2205	protein histidine kinase activity
M673_12275	COG0745	RESPONSE REGULATOR receiver
M673_12290	COG2847	Copper chaperone PCu(A)C
M673_12300	COG1999	signal sequence binding
M673_12305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M673_12310	COG0697	spore germination
M673_12320	COG1596	polysaccharide export
M673_12350	COG0784	Response regulator, receiver
M673_12350	COG4191	Histidine kinase
M673_12360	COG0784	Response regulator, receiver
M673_12400	COG3772	lysozyme
M673_12540	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M673_12545	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M673_12570	COG3750	Belongs to the UPF0335 family
M673_12765	COG3387	PFAM Glycoside hydrolase 15-related
M673_12780	COG0776	regulation of translation
M673_12790	COG0416	fatty acid biosynthetic process
M673_12810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M673_12815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M673_12825	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M673_12825	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M673_12830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M673_12835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M673_12855	COG0113	porphobilinogen synthase activity
M673_12865	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
M673_12870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M673_12885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M673_12890	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M673_12900	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
M673_12910	COG0628	permease
M673_12915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M673_12920	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M673_12925	COG0243	molybdopterin cofactor binding
M673_12930	COG1902	pentaerythritol trinitrate reductase activity
M673_12935	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
M673_12945	COG0625	glutathione transferase activity
M673_12955	COG0322	excinuclease ABC activity
M673_12960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M673_12970	COG0314	molybdopterin synthase activity
M673_12975	COG0105	UTP biosynthetic process
M673_12990	COG0488	(ABC) transporter
M673_13005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M673_13020	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M673_13025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M673_13030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M673_13035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M673_13040	COG0194	GDP metabolic process
M673_13045	COG1561	YicC-like family, N-terminal region
M673_13050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M673_13055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M673_13070	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M673_13075	COG0360	Binds together with S18 to 16S ribosomal RNA
M673_13090	COG0359	binds to the 23S rRNA
M673_13095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M673_13105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M673_13120	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M673_13125	COG1028	Short-chain dehydrogenase reductase Sdr
M673_13135	COG1183	phosphatidylcholine synthase activity
M673_13140	COG0688	phosphatidylethanolamine metabolic process
M673_13145	COG5265	(ABC) transporter
M673_13165	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M673_13175	COG1959	2 iron, 2 sulfur cluster binding
M673_13190	COG0411	ABC transporter
M673_13220	COG1268	BioY protein
M673_13225	COG1122	ATPase activity
M673_13230	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M673_13240	COG2962	Rard protein
M673_13255	COG0215	cysteine-tRNA ligase activity
M673_13270	COG1363	Peptidase, m42
M673_13300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M673_13310	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
M673_13320	COG1381	Involved in DNA repair and RecF pathway recombination
M673_13340	COG0736	holo-[acyl-carrier-protein] synthase activity
M673_13370	COG1573	uracil-dna glycosylase
M673_13380	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M673_13385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M673_13390	COG0741	lytic transglycosylase activity
M673_13400	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M673_13405	COG1349	DNA-binding transcription factor activity
M673_13410	COG1070	Carbohydrate kinase
M673_13415	COG1879	ABC-type sugar transport system periplasmic component
M673_13420	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_13425	COG1129	ABC transporter
M673_13465	COG0321	lipoyl(octanoyl) transferase activity
M673_13470	COG1671	Belongs to the UPF0178 family
M673_13480	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M673_13490	COG0546	phosphoglycolate phosphatase activity
M673_13500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M673_13505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M673_13525	COG0203	ribosomal protein L17
M673_13535	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M673_13540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M673_13545	COG0563	adenylate kinase activity
M673_13555	COG0200	Binds to the 23S rRNA
M673_13565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M673_13575	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M673_13585	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M673_13590	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M673_13595	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M673_13600	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M673_13605	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M673_13610	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M673_13620	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M673_13625	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M673_13630	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M673_13635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M673_13640	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M673_13645	COG0089	rRNA binding
M673_13650	COG0088	Forms part of the polypeptide exit tunnel
M673_13655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M673_13665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M673_13670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M673_13675	COG0049	tRNA binding
M673_13680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M673_13685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M673_13690	COG0085	RNA polymerase activity
M673_13695	COG0222	ribosome binding
M673_13700	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M673_13705	COG0081	regulation of translation
M673_13710	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M673_13740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M673_13755	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M673_13770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
M673_13775	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M673_13780	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
M673_13800	COG4149	molybdate abc transporter
M673_13805	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
M673_13850	COG1335	isochorismatase
M673_13865	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M673_13870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M673_13880	COG2124	cytochrome p450
M673_13890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M673_13895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M673_13900	COG0010	Belongs to the arginase family
M673_13905	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M673_13910	COG1612	heme a metabolic process
M673_13925	COG1596	polysaccharide export
M673_13935	COG0251	oxidation-reduction process
M673_13945	COG1732	Glycine betaine
M673_13955	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
M673_13960	COG2894	cell division
M673_13965	COG0850	regulation of cytokinetic process
M673_13990	COG0438	transferase activity, transferring glycosyl groups
M673_14005	COG1091	dTDP-4-dehydrorhamnose reductase activity
M673_14010	COG1088	dTDP-glucose 4,6-dehydratase activity
M673_14015	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M673_14035	COG2308	Evidence 4 Homologs of previously reported genes of
M673_14055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M673_14070	COG0697	spore germination
M673_14075	COG0746	molybdenum cofactor guanylyltransferase activity
M673_14080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M673_14095	COG2084	Dehydrogenase
M673_14100	COG1522	sequence-specific DNA binding
M673_14105	COG1573	uracil-dna glycosylase
M673_14110	COG2202	Pas domain
M673_14110	COG2205	protein histidine kinase activity
M673_14120	COG3577	Aspartyl protease
M673_14130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M673_14135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M673_14145	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M673_14160	COG5001	Diguanylate cyclase
M673_14165	COG0784	Response regulator, receiver
M673_14195	COG1088	dTDP-glucose 4,6-dehydratase activity
M673_14210	COG0546	phosphoglycolate phosphatase activity
M673_14210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M673_14230	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M673_14240	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M673_14255	COG0440	acetolactate synthase activity
M673_14260	COG0028	Belongs to the TPP enzyme family
M673_14275	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M673_14280	COG0560	Phosphoserine phosphatase
M673_14295	COG0330	HflC and HflK could
M673_14300	COG0330	HflC and HflK could
M673_14310	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M673_14315	COG5000	phosphorelay sensor kinase activity
M673_14340	COG0210	DNA helicase
M673_14370	COG0006	proline dipeptidase activity
M673_14375	COG1960	acyl-CoA dehydrogenase activity
M673_14385	COG0183	Belongs to the thiolase family
M673_14395	COG1250	3-hydroxyacyl-CoA dehydrogenase
M673_14395	COG1024	Enoyl-CoA hydratase
M673_14400	COG1295	ribonuclease BN
M673_14415	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
M673_14420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M673_14440	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M673_14445	COG0861	Integral membrane protein TerC family
M673_14450	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M673_14455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M673_14455	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M673_14465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M673_14490	COG0625	glutathione transferase activity
M673_14505	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M673_14515	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
M673_14540	COG0308	aminopeptidase N
M673_14545	COG2205	protein histidine kinase activity
M673_14545	COG2202	Pas domain
M673_14555	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
M673_14560	COG2205	protein histidine kinase activity
M673_14570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M673_14575	COG3088	subunit of a heme lyase
M673_14580	COG1138	Cytochrome C-type biogenesis protein
M673_14585	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M673_14590	COG4235	cytochrome complex assembly
M673_14605	COG0745	RESPONSE REGULATOR receiver
M673_14695	COG4695	Portal protein
M673_14710	COG2983	Belongs to the UPF0260 family
M673_14720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M673_14755	COG2205	protein histidine kinase activity
M673_14765	COG2166	iron-sulfur cluster assembly
M673_14795	COG1064	alcohol dehydrogenase
M673_14800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M673_14810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M673_14815	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
M673_14820	COG2080	2 iron, 2 sulfur cluster binding
M673_14825	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
M673_14835	COG0697	spore germination
M673_14840	COG2094	Belongs to the DNA glycosylase MPG family
M673_14850	COG0673	inositol 2-dehydrogenase activity
M673_14855	COG0482	sulfurtransferase activity
M673_14870	COG0745	RESPONSE REGULATOR receiver
M673_14910	COG0784	Response regulator, receiver
M673_14910	COG4191	Histidine kinase
M673_14935	COG0564	pseudouridine synthase activity
M673_14940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M673_14945	COG0514	ATP-dependent DNA helicase (RecQ)
M673_14955	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M673_14965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M673_14985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M673_14990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M673_14995	COG0037	tRNA processing
M673_15005	COG2885	chlorophyll binding
M673_15010	COG0823	Involved in the tonB-independent uptake of proteins
M673_15030	COG0824	Thioesterase
M673_15040	COG0217	transcriptional regulatory protein
M673_15050	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M673_15070	COG2255	four-way junction helicase activity
M673_15080	COG1692	metallophosphoesterase
M673_15085	COG0625	glutathione transferase activity
M673_15090	COG2340	Cysteine-rich secretory protein family
M673_15095	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M673_15105	COG0778	Nitroreductase
M673_15130	COG0126	phosphoglycerate kinase activity
M673_15140	COG1132	(ABC) transporter
M673_15145	COG1793	dna ligase
M673_15145	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
M673_15165	COG1201	RNA secondary structure unwinding
M673_15175	COG0659	secondary active sulfate transmembrane transporter activity
M673_15195	COG0730	response to heat
M673_15215	COG2264	protein methyltransferase activity
M673_15220	COG1999	signal sequence binding
M673_15230	COG2814	Major facilitator Superfamily
M673_15255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M673_15265	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M673_15275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M673_15280	COG0849	cell division
M673_15285	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M673_15290	COG1181	Belongs to the D-alanine--D-alanine ligase family
M673_15300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M673_15305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M673_15315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M673_15320	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M673_15330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M673_15345	COG0275	rRNA processing
M673_15350	COG2001	Belongs to the MraZ family
M673_15360	COG3023	N-Acetylmuramoyl-L-alanine amidase
M673_15385	COG0752	glycyl-tRNA synthetase alpha subunit
M673_15410	COG0142	geranyltranstransferase activity
M673_15420	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M673_15425	COG0521	Mo-molybdopterin cofactor biosynthetic process
M673_15440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M673_15445	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M673_15450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M673_15455	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M673_15460	COG0356	it plays a direct role in the translocation of protons across the membrane
M673_15475	COG1160	GTP binding
M673_15515	COG1684	flagellar biosynthetic protein fliR
M673_15520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M673_15525	COG4794	Type iii secretion
M673_15530	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M673_15535	COG5443	negative regulation of bacterial-type flagellum assembly
M673_15540	COG5442	Flagellar protein FlaF
M673_15550	COG1749	Flagellar hook protein flgE
M673_15575	COG1360	Flagellar Motor Protein
M673_15585	COG1766	The M ring may be actively involved in energy transduction
M673_15595	COG2433	Pfam Transposase IS66
M673_15600	COG3436	PFAM IS66 Orf2 family protein
M673_15605	COG2963	transposase activity
M673_15610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M673_15615	COG1338	Plays a role in the flagellum-specific transport system
M673_15625	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
M673_15635	COG1706	bacterial-type flagellum-dependent cell motility
M673_15640	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
M673_15645	COG4786	Flagellar basal body rod
M673_15650	COG1677	Flagellar hook-basal body complex protein FliE
M673_15655	COG1558	bacterial-type flagellum-dependent cell motility
M673_15660	COG1815	bacterial-type flagellum-dependent cell motility
M673_15670	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M673_15675	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M673_15680	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M673_15695	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M673_15700	COG4786	Flagellar basal body rod
M673_15705	COG1157	protein secretion by the type III secretion system
M673_15725	COG2354	Protein conserved in bacteria
M673_15730	COG1686	Belongs to the peptidase S11 family
M673_15740	COG3920	Histidine kinase
M673_15740	COG2202	Pas domain
M673_15745	COG0513	Belongs to the DEAD box helicase family
M673_15765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M673_15765	COG2010	Cytochrome c
M673_15770	COG2080	2 iron, 2 sulfur cluster binding
M673_15775	COG1529	Aldehyde oxidase and xanthine dehydrogenase
M673_15775	COG2010	Cytochrome c
M673_15780	COG1301	dicarboxylic acid transport
M673_15785	COG4191	Histidine kinase
M673_15790	COG2204	response regulator
M673_15815	COG3416	Protein conserved in bacteria
M673_15820	COG0531	amino acid
M673_15825	COG0546	phosphoglycolate phosphatase activity
M673_15835	COG0367	asparagine synthase
M673_15840	COG0456	acetyltransferase
M673_15845	COG1363	Peptidase, m42
M673_15850	COG3290	protein histidine kinase activity
M673_15850	COG0840	transmembrane signaling receptor activity
M673_15910	COG2967	ApaG domain
M673_15915	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M673_15925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M673_15945	COG0745	RESPONSE REGULATOR receiver
M673_15950	COG0704	Plays a role in the regulation of phosphate uptake
M673_15965	COG0573	inorganic phosphate transmembrane transporter activity
M673_15985	COG3387	PFAM Glycoside hydrolase 15-related
M673_16010	COG0254	rRNA binding
M673_16015	COG1132	(ABC) transporter
M673_16030	COG0483	inositol monophosphate 1-phosphatase activity
M673_16035	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M673_16060	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M673_16065	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M673_16070	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M673_16075	COG0457	Tetratricopeptide repeat
M673_16080	COG0469	pyruvate kinase activity
M673_16095	COG3750	Belongs to the UPF0335 family
M673_16100	COG4957	zinc ion binding
M673_16125	COG5310	Homospermidine synthase
M673_16140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M673_16145	COG0840	transmembrane signaling receptor activity
M673_16155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M673_16165	COG1509	lysine 2,3-aminomutase activity
M673_16195	COG1278	Cold shock
M673_16225	COG1196	nuclear chromosome segregation
M673_16225	COG3264	Mechanosensitive ion channel
M673_16235	COG2353	YceI-like domain
M673_16240	COG0697	spore germination
M673_16250	COG2721	sulfolactate sulfo-lyase activity
M673_16260	COG4948	Mandelate Racemase Muconate Lactonizing
M673_16270	COG1028	Short-chain dehydrogenase reductase Sdr
M673_16285	COG1129	ABC transporter
M673_16290	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_16305	COG1063	alcohol dehydrogenase
M673_16310	COG1725	Transcriptional regulator
M673_16330	COG0395	ABC-type sugar transport system, permease component
M673_16335	COG3842	ATPase activity
M673_16340	COG3142	Participates in the control of copper homeostasis
M673_16345	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M673_16350	COG0395	ABC-type sugar transport system, permease component
M673_16410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M673_16420	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M673_16425	COG0739	heme binding
M673_16425	COG1196	nuclear chromosome segregation
M673_16425	COG0741	lytic transglycosylase activity
M673_16430	COG0667	Aldo Keto reductase
M673_16440	COG1376	ErfK ybiS ycfS ynhG family protein
M673_16445	COG0656	L-ascorbic acid biosynthetic process
M673_16455	COG0542	response to heat
M673_16465	COG2890	protein-(glutamine-N5) methyltransferase activity
M673_16470	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M673_16480	COG0527	aspartate kinase activity
M673_16485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M673_16515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M673_16525	COG1040	competence protein
M673_16530	COG2226	methyltransferase
M673_16545	COG0494	nUDIX hydrolase
M673_16555	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M673_16560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M673_16565	COG0653	protein targeting
M673_16575	COG0825	malonyl-CoA metabolic process
M673_16580	COG4974	Belongs to the 'phage' integrase family
M673_16590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M673_16595	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M673_16630	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M673_16635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M673_16645	COG0384	phenazine biosynthesis protein PhzF
M673_16675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M673_16685	COG0667	Aldo Keto reductase
M673_16695	COG2264	protein methyltransferase activity
M673_16700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
M673_16705	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M673_16710	COG0287	Prephenate dehydrogenase
M673_16740	COG2884	Cell division ATP-binding protein ftsE
M673_16760	COG4106	trans-aconitate 2-methyltransferase activity
M673_16780	COG0165	Argininosuccinate lyase
M673_16785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M673_16790	COG1250	3-hydroxyacyl-CoA dehydrogenase
M673_16795	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M673_16800	COG2086	electron transfer activity
M673_16825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M673_16885	COG1396	sequence-specific DNA binding
M673_16895	COG0745	RESPONSE REGULATOR receiver
M673_16905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M673_16915	COG2205	protein histidine kinase activity
M673_16920	COG0745	RESPONSE REGULATOR receiver
M673_16940	COG0438	transferase activity, transferring glycosyl groups
M673_16980	COG5002	protein histidine kinase activity
M673_16985	COG0745	RESPONSE REGULATOR receiver
M673_16990	COG0745	RESPONSE REGULATOR receiver
M673_16995	COG1846	Transcriptional regulator
M673_17035	COG1879	ABC-type sugar transport system periplasmic component
M673_17040	COG1129	ABC transporter
M673_17045	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_17050	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_17055	COG0280	phosphate acetyltransferase
M673_17055	COG0281	malic enzyme
M673_17065	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M673_17070	COG0840	transmembrane signaling receptor activity
M673_17085	COG1280	lysine exporter protein (LysE YggA)
M673_17095	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
M673_17105	COG0561	phosphatase activity
M673_17110	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
M673_17130	COG0848	biopolymer transport protein
M673_17165	COG0642	Histidine kinase
M673_17210	COG0745	RESPONSE REGULATOR receiver
M673_17215	COG2205	protein histidine kinase activity
M673_17215	COG0784	Response regulator, receiver
M673_17220	COG0471	metal ion transport
M673_17220	COG3273	potassium ion transport
M673_17255	COG0861	Integral membrane protein TerC family
M673_17265	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
M673_17270	COG1304	FMN binding
M673_17325	COG0840	transmembrane signaling receptor activity
M673_17330	COG1573	uracil-dna glycosylase
M673_17340	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M673_17345	COG2115	Belongs to the xylose isomerase family
M673_17350	COG1609	Transcriptional regulator
M673_17355	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M673_17395	COG2197	response regulator
M673_17405	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M673_17415	COG1088	dTDP-glucose 4,6-dehydratase activity
M673_17430	COG0268	Binds directly to 16S ribosomal RNA
M673_17515	COG1192	Involved in chromosome partitioning
M673_17520	COG1475	DNA binding
M673_17525	COG0640	Transcriptional regulator
M673_17530	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
M673_17545	COG1802	Transcriptional regulator
M673_17565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M673_17570	COG1959	2 iron, 2 sulfur cluster binding
M673_17580	COG1802	Transcriptional regulator
M673_17610	COG0246	Mannitol dehydrogenase
M673_17625	COG1120	ATPase activity
M673_17635	COG1609	Transcriptional regulator
M673_17640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M673_17655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_17660	COG2202	Pas domain
M673_17660	COG3920	Histidine kinase
M673_17665	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M673_17690	COG3708	Transcriptional regulator
M673_17690	COG2207	Transcriptional regulator
M673_17710	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M673_17720	COG1278	Cold shock
M673_17725	COG1233	COG1233 Phytoene dehydrogenase and related
M673_17730	COG4191	Histidine kinase
M673_17730	COG0784	Response regulator, receiver
M673_17750	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_17755	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_17760	COG1129	ABC transporter
M673_17765	COG1879	ABC-type sugar transport system periplasmic component
M673_17775	COG2197	response regulator
M673_17810	COG5001	Diguanylate cyclase
M673_17810	COG3300	MHYT domain
M673_17825	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
M673_17830	COG3454	Phosphonate metabolism
M673_17835	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
M673_17840	COG3639	organic phosphonate transmembrane transporter activity
M673_17845	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
M673_17850	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
M673_17860	COG4778	phosphonate C-P lyase system protein PhnL
M673_17865	COG4107	phosphonate C-P lyase system protein PhnK
M673_17870	COG3627	carbon phosphorus lyase activity
M673_17875	COG3626	phosphonate metabolism
M673_17880	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
M673_17885	COG3624	Phosphonate C-P lyase system protein PhnG
M673_17890	COG1609	Transcriptional regulator
M673_17920	COG3708	Transcriptional regulator
M673_17920	COG2207	Transcriptional regulator
M673_17950	COG2770	Histidine kinase
M673_17950	COG2208	phosphoserine phosphatase activity
M673_17960	COG2205	protein histidine kinase activity
M673_17960	COG0784	Response regulator, receiver
M673_17960	COG5002	protein histidine kinase activity
M673_17970	COG0745	RESPONSE REGULATOR receiver
M673_17975	COG2815	serine threonine protein kinase
M673_17975	COG0515	serine threonine protein kinase
M673_17980	COG0500	methyltransferase
M673_18025	COG3501	Rhs element vgr protein
M673_18040	COG1366	Belongs to the anti-sigma-factor antagonist family
M673_18055	COG2835	tetraacyldisaccharide 4'-kinase activity
M673_18095	COG0673	inositol 2-dehydrogenase activity
M673_18100	COG1082	Xylose isomerase domain protein TIM barrel
M673_18105	COG1609	Transcriptional regulator
M673_18110	COG3284	Transcriptional regulator
M673_18115	COG1063	alcohol dehydrogenase
M673_18125	COG1968	undecaprenyl-diphosphatase activity
M673_18130	COG1595	DNA-templated transcription, initiation
M673_18150	COG1462	curli production assembly transport component CsgG
M673_18190	COG1012	belongs to the aldehyde dehydrogenase family
M673_18200	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M673_18240	COG1959	2 iron, 2 sulfur cluster binding
M673_18245	COG3634	alkyl hydroperoxide reductase activity
M673_18250	COG1522	sequence-specific DNA binding
M673_18285	COG0601	transmembrane transport
M673_18300	COG0583	DNA-binding transcription factor activity
M673_18335	COG2197	response regulator
M673_18355	COG0318	PFAM AMP-dependent synthetase and ligase
M673_18400	COG0463	Glycosyl transferase, family 2
M673_18410	COG0297	glycogen (starch) synthase activity
M673_18420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M673_18430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M673_18450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M673_18455	COG1609	Transcriptional regulator
M673_18460	COG3608	succinylglutamate desuccinylase aspartoacylase
M673_18465	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
M673_18475	COG0765	amino acid transport
M673_18485	COG1879	ABC-type sugar transport system periplasmic component
M673_18490	COG1129	ABC transporter
M673_18495	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_18500	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_18560	COG0559	Belongs to the binding-protein-dependent transport system permease family
M673_18580	COG2376	Dihydroxyacetone kinase
M673_18585	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_18590	COG1129	ABC transporter
M673_18620	COG2011	ABC-type metal ion transport system permease component
M673_18625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M673_18635	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M673_18640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M673_18660	COG0579	oxidoreductase
M673_18675	COG0601	transmembrane transport
M673_18680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_18690	COG4608	Belongs to the ABC transporter superfamily
M673_18695	COG0154	amidase activity
M673_18705	COG1914	H( )-stimulated, divalent metal cation uptake system
M673_18710	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M673_18715	COG4336	lyase activity
M673_18720	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M673_18725	COG4770	biotin carboxylase activity
M673_18735	COG0583	DNA-binding transcription factor activity
M673_18755	COG0277	FAD linked oxidase domain protein
M673_18765	COG4598	ABC transporter
M673_18770	COG0765	amino acid transport
M673_18775	COG0765	amino acid transport
M673_18785	COG2986	histidine ammonia-lyase
M673_18805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M673_18810	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M673_18815	COG4988	ABC transporter
M673_18820	COG1271	oxidase subunit
M673_18825	COG1294	oxidase, subunit
M673_18835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M673_18855	COG1082	Xylose isomerase domain protein TIM barrel
M673_18860	COG3962	Belongs to the TPP enzyme family
M673_18865	COG0673	inositol 2-dehydrogenase activity
M673_18870	COG0673	inositol 2-dehydrogenase activity
M673_18875	COG4211	Belongs to the binding-protein-dependent transport system permease family
M673_18880	COG1129	ABC transporter
M673_18905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M673_18915	COG3718	enzyme involved in inositol metabolism
M673_18955	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_18970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M673_18990	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M673_19000	COG0028	Belongs to the TPP enzyme family
M673_19005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M673_19010	COG1177	transmembrane transport
M673_19015	COG1176	ABC-type spermidine putrescine transport system, permease component I
M673_19020	COG3842	ATPase activity
M673_19030	COG1396	sequence-specific DNA binding
M673_19030	COG1917	Cupin 2, conserved barrel domain protein
M673_19040	COG1802	Transcriptional regulator
M673_19045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M673_19060	COG1960	acyl-CoA dehydrogenase activity
M673_19065	COG0583	DNA-binding transcription factor activity
M673_19080	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
M673_19085	COG0431	NADPH-dependent FMN reductase
M673_19095	COG0411	ABC transporter
M673_19130	COG3842	ATPase activity
M673_19150	COG1175	transmembrane transport
M673_19175	COG1175	transmembrane transport
M673_19180	COG3833	ABC-type maltose transport systems, permease component
M673_19190	COG1940	carbohydrate kinase activity
M673_19215	COG1396	sequence-specific DNA binding
M673_19230	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M673_19230	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
M673_19250	COG0438	transferase activity, transferring glycosyl groups
M673_19275	COG2224	Isocitrate lyase
M673_19295	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M673_19300	COG0720	synthase
M673_19305	COG0602	queuosine metabolic process
M673_19310	COG2130	NADP-dependent
M673_19315	COG5001	Diguanylate cyclase
M673_19315	COG3300	MHYT domain
M673_19320	COG3842	ATPase activity
M673_19345	COG0420	3'-5' exonuclease activity
M673_19350	COG4717	serine-type aminopeptidase activity
M673_19370	COG3546	catalase activity
M673_19375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M673_19450	COG1653	transport
M673_19455	COG1175	transmembrane transport
M673_19490	COG1607	acyl-coa hydrolase
M673_19500	COG1733	regulation of RNA biosynthetic process
M673_19510	COG5507	3-demethylubiquinone-9 3-methyltransferase
M673_19520	COG0840	transmembrane signaling receptor activity
M673_19525	COG2239	Acts as a magnesium transporter
M673_19530	COG1461	Dihydroxyacetone kinase
M673_19535	COG2376	Dihydroxyacetone kinase
M673_19545	COG2376	Dihydroxyacetone kinase
M673_19550	COG1028	Short-chain dehydrogenase reductase Sdr
M673_19555	COG1879	ABC-type sugar transport system periplasmic component
M673_19560	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_19565	COG1129	ABC transporter
M673_19575	COG0598	Magnesium transport protein CorA
M673_19580	COG0840	transmembrane signaling receptor activity
M673_19580	COG3290	protein histidine kinase activity
M673_19610	COG2390	Transcriptional regulator
M673_19635	COG1192	Involved in chromosome partitioning
M673_19640	COG1475	DNA binding
M673_19685	COG4325	translation initiation factor activity
M673_19690	COG0438	transferase activity, transferring glycosyl groups
M673_19695	COG0438	transferase activity, transferring glycosyl groups
M673_19720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M673_19725	COG0765	amino acid transport
M673_19730	COG1126	abc transporter atp-binding protein
M673_19735	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M673_19745	COG0840	transmembrane signaling receptor activity
M673_19770	COG0840	transmembrane signaling receptor activity
M673_19780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M673_19820	COG2204	response regulator
M673_19830	COG1028	Short-chain dehydrogenase reductase Sdr
M673_19835	COG1069	ribulokinase activity
M673_19845	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_19855	COG1879	ABC-type sugar transport system periplasmic component
M673_19865	COG3300	MHYT domain
M673_19865	COG5001	Diguanylate cyclase
M673_19880	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M673_19900	COG0840	transmembrane signaling receptor activity
M673_19900	COG3290	protein histidine kinase activity
M673_19905	COG0583	DNA-binding transcription factor activity
M673_19910	COG2828	Protein conserved in bacteria
M673_19925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M673_19935	COG1902	pentaerythritol trinitrate reductase activity
M673_19960	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M673_19980	COG4221	oxidoreductase activity
M673_20010	COG1959	2 iron, 2 sulfur cluster binding
M673_20020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M673_20025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M673_20030	COG0745	RESPONSE REGULATOR receiver
M673_20035	COG0642	Histidine kinase
M673_20050	COG1475	DNA binding
M673_20065	COG0019	diaminopimelate decarboxylase activity
M673_20070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M673_20080	COG1120	ATPase activity
M673_20085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M673_20090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M673_20105	COG1176	ABC-type spermidine putrescine transport system, permease component I
M673_20110	COG1177	transmembrane transport
M673_20120	COG3842	ATPase activity
M673_20140	COG2909	trisaccharide binding
M673_20165	COG1733	regulation of RNA biosynthetic process
M673_20185	COG5001	Diguanylate cyclase
M673_20240	COG0583	DNA-binding transcription factor activity
M673_20260	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M673_20260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M673_20265	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M673_20295	COG2124	cytochrome p450
M673_20310	COG1073	alpha beta
M673_20325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M673_20330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M673_20340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M673_20345	COG3842	ATPase activity
M673_20355	COG1840	ABC-type Fe3 transport system, periplasmic component
M673_20385	COG0765	amino acid transport
M673_20390	COG1126	abc transporter atp-binding protein
M673_20400	COG0277	FAD linked oxidase domain protein
M673_20415	COG3833	ABC-type maltose transport systems, permease component
M673_20420	COG1176	ABC-type spermidine putrescine transport system, permease component I
M673_20430	COG3842	ATPase activity
M673_20435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M673_20445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M673_20450	COG2086	electron transfer activity
M673_20460	COG1012	belongs to the aldehyde dehydrogenase family
M673_20465	COG0277	FAD linked oxidase domain protein
M673_20470	COG5383	Protein conserved in bacteria
M673_20475	COG0583	DNA-binding transcription factor activity
M673_20480	COG3842	ATPase activity
M673_20490	COG0395	ABC-type sugar transport system, permease component
M673_20505	COG0183	Belongs to the thiolase family
M673_20510	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M673_20535	COG0673	inositol 2-dehydrogenase activity
M673_20540	COG0673	inositol 2-dehydrogenase activity
M673_20550	COG4214	carbohydrate transport
M673_20560	COG4213	ABC transporter substrate-binding protein
M673_20565	COG0583	DNA-binding transcription factor activity
M673_20580	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_20585	COG1129	ABC transporter
M673_20630	COG0667	Aldo Keto reductase
M673_20645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M673_20655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M673_20665	COG1126	abc transporter atp-binding protein
M673_20690	COG4172	Belongs to the ABC transporter superfamily
M673_20700	COG0747	negative chemotaxis
M673_20725	COG1396	sequence-specific DNA binding
M673_20735	COG0840	transmembrane signaling receptor activity
M673_20740	COG3706	GGDEF domain
M673_20755	COG0840	transmembrane signaling receptor activity
M673_20765	COG1028	Short-chain dehydrogenase reductase Sdr
M673_20775	COG0477	Major facilitator Superfamily
M673_20780	COG0488	(ABC) transporter
M673_20785	COG1082	Xylose isomerase domain protein TIM barrel
M673_20800	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_20805	COG1737	Transcriptional regulator
M673_20815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M673_20830	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_20835	COG1129	ABC transporter
M673_20840	COG1879	ABC-type sugar transport system periplasmic component
M673_20845	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M673_20850	COG1349	DNA-binding transcription factor activity
M673_20860	COG0753	catalase activity
M673_20865	COG0483	inositol monophosphate 1-phosphatase activity
M673_20870	COG3842	ATPase activity
M673_20880	COG1840	ABC-type Fe3 transport system, periplasmic component
M673_20885	COG1609	Transcriptional regulator
M673_20915	COG3706	GGDEF domain
M673_20925	COG3842	ATPase activity
M673_20950	COG0673	inositol 2-dehydrogenase activity
M673_20955	COG1609	Transcriptional regulator
M673_21020	COG4302	ethanolamine ammonia-lyase activity
M673_21035	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M673_21040	COG4605	iron ion homeostasis
M673_21045	COG4604	ABC transporter, ATP-binding protein
M673_21050	COG4774	siderophore transport
M673_21060	COG4264	IucA IucC family
M673_21075	COG1082	Xylose isomerase domain protein TIM barrel
M673_21080	COG0306	phosphate transporter
M673_21090	COG1116	anion transmembrane transporter activity
M673_21100	COG4191	Histidine kinase
M673_21105	COG4566	intracellular signal transduction
M673_21125	COG4221	oxidoreductase activity
M673_21145	COG0667	Aldo Keto reductase
M673_21170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M673_21180	COG0251	oxidation-reduction process
M673_21185	COG3585	molybdate ion transport
M673_21200	COG0640	Transcriptional regulator
M673_21215	COG0730	response to heat
M673_21220	COG3453	Protein conserved in bacteria
M673_21220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M673_21240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M673_21250	COG1802	Transcriptional regulator
M673_21270	COG0754	glutathionylspermidine amidase activity
M673_21280	COG3766	membrane
M673_21290	COG3789	protein conserved in bacteria
M673_21295	COG1842	Phage shock protein A
M673_21320	COG0559	Belongs to the binding-protein-dependent transport system permease family
M673_21350	COG0235	Class ii aldolase
M673_21365	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_21370	COG1129	ABC transporter
M673_21380	COG1609	Transcriptional regulator
M673_21385	COG1082	Xylose isomerase domain protein TIM barrel
M673_21400	COG0586	Pfam SNARE associated Golgi protein
M673_21405	COG1253	flavin adenine dinucleotide binding
M673_21415	COG0642	Histidine kinase
M673_21425	COG2194	sulfuric ester hydrolase activity
M673_21445	COG3300	MHYT domain
M673_21445	COG5001	Diguanylate cyclase
M673_21450	COG3300	MHYT domain
M673_21450	COG5001	Diguanylate cyclase
M673_21460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M673_21470	COG0765	amino acid transport
M673_21480	COG0251	oxidation-reduction process
M673_21495	COG0625	glutathione transferase activity
M673_21500	COG3706	GGDEF domain
M673_21505	COG3300	MHYT domain
M673_21505	COG5001	Diguanylate cyclase
M673_21510	COG0494	nUDIX hydrolase
M673_21515	COG1349	DNA-binding transcription factor activity
M673_21520	COG0784	Response regulator, receiver
M673_21520	COG4191	Histidine kinase
M673_21545	COG3706	GGDEF domain
M673_21550	COG3214	Protein conserved in bacteria
M673_21555	COG0667	Aldo Keto reductase
M673_21565	COG3300	MHYT domain
M673_21565	COG5001	Diguanylate cyclase
M673_21615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M673_21635	COG0789	Transcriptional regulator
M673_21645	COG0784	Response regulator, receiver
M673_21645	COG2205	protein histidine kinase activity
M673_21655	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
M673_21660	COG1192	Involved in chromosome partitioning
M673_21665	COG1475	DNA binding
M673_21670	COG3706	GGDEF domain
M673_21670	COG0745	RESPONSE REGULATOR receiver
M673_21685	COG0765	amino acid transport
M673_21695	COG2186	Transcriptional regulator
M673_21710	COG0840	transmembrane signaling receptor activity
M673_21715	COG0840	transmembrane signaling receptor activity
M673_21720	COG2267	carboxylic ester hydrolase activity
M673_21722	COG0840	transmembrane signaling receptor activity
M673_21725	COG2186	Transcriptional regulator
M673_21735	COG1129	ABC transporter
M673_21750	COG4948	Mandelate Racemase Muconate Lactonizing
M673_21755	COG1028	Short-chain dehydrogenase reductase Sdr
M673_21765	COG1733	regulation of RNA biosynthetic process
M673_21780	COG5001	Diguanylate cyclase
M673_21780	COG3300	MHYT domain
M673_21800	COG0235	Class ii aldolase
M673_21805	COG2267	carboxylic ester hydrolase activity
M673_21810	COG2197	response regulator
M673_21815	COG0747	negative chemotaxis
M673_21820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_21830	COG0444	Belongs to the ABC transporter superfamily
M673_21835	COG4608	Belongs to the ABC transporter superfamily
M673_21870	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
M673_21880	COG1228	amidohydrolase
M673_21885	COG2986	histidine ammonia-lyase
M673_21890	COG0402	S-adenosylhomocysteine deaminase activity
M673_21905	COG1522	sequence-specific DNA binding
M673_21910	COG0673	inositol 2-dehydrogenase activity
M673_21920	COG3842	ATPase activity
M673_21925	COG0395	ABC-type sugar transport system, permease component
M673_21940	COG1609	Transcriptional regulator
M673_21945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M673_21950	COG4139	cobalamin transport
M673_21955	COG1120	ATPase activity
M673_21970	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
M673_21975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M673_21980	COG1609	Transcriptional regulator
M673_21985	COG1063	alcohol dehydrogenase
M673_21990	COG1028	Short-chain dehydrogenase reductase Sdr
M673_22000	COG0583	DNA-binding transcription factor activity
M673_22007	COG3842	ATPase activity
M673_22025	COG3842	ATPase activity
M673_22040	COG0395	ABC-type sugar transport system, permease component
M673_22055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M673_22060	COG5001	Diguanylate cyclase
M673_22060	COG3300	MHYT domain
M673_22070	COG4774	siderophore transport
M673_22080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M673_22095	COG1028	Short-chain dehydrogenase reductase Sdr
M673_22115	COG1653	transport
M673_22145	COG0673	inositol 2-dehydrogenase activity
M673_22150	COG1940	carbohydrate kinase activity
M673_22155	COG0483	inositol monophosphate 1-phosphatase activity
M673_22185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M673_22200	COG1129	ABC transporter
M673_22215	COG1129	ABC transporter
M673_22220	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_22225	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_22240	COG1028	Short-chain dehydrogenase reductase Sdr
M673_22245	COG0246	Mannitol dehydrogenase
M673_22280	COG1335	isochorismatase
M673_22290	COG4977	sequence-specific DNA binding
M673_22335	COG4953	penicillin-binding protein 1C
M673_22345	COG0477	Major facilitator Superfamily
M673_22360	COG1028	Short-chain dehydrogenase reductase Sdr
M673_22370	COG1312	Catalyzes the dehydration of D-mannonate
M673_22375	COG1940	carbohydrate kinase activity
M673_22380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M673_22390	COG1082	Xylose isomerase domain protein TIM barrel
M673_22395	COG0673	inositol 2-dehydrogenase activity
M673_22415	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_22420	COG1879	ABC-type sugar transport system periplasmic component
M673_22425	COG2390	Transcriptional regulator
M673_22430	COG3684	Belongs to the aldolase LacD family
M673_22435	COG1940	carbohydrate kinase activity
M673_22450	COG0673	inositol 2-dehydrogenase activity
M673_22455	COG0673	inositol 2-dehydrogenase activity
M673_22460	COG3794	PFAM blue (type 1) copper domain protein
M673_22475	COG0346	lactoylglutathione lyase activity
M673_22485	COG1921	L-seryl-tRNASec selenium transferase activity
M673_22510	COG3964	amidohydrolase
M673_22520	COG0601	transmembrane transport
M673_22530	COG3842	ATPase activity
M673_22550	COG1024	Enoyl-CoA hydratase
M673_22560	COG1960	acyl-CoA dehydrogenase activity
M673_22575	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M673_22600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M673_22605	COG1396	sequence-specific DNA binding
M673_22605	COG3800	Transcriptional regulator
M673_22615	COG0583	DNA-binding transcription factor activity
M673_22635	COG3383	formate dehydrogenase (NAD+) activity
M673_22645	COG0114	fumarate hydratase activity
M673_22650	COG1301	dicarboxylic acid transport
M673_22665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M673_22670	COG3842	ATPase activity
M673_22695	COG1609	Transcriptional regulator
M673_22700	COG0604	alcohol dehydrogenase
M673_22705	COG4221	oxidoreductase activity
M673_22710	COG2207	Transcriptional regulator
M673_22715	COG4948	Mandelate Racemase Muconate Lactonizing
M673_22720	COG4948	Mandelate Racemase Muconate Lactonizing
M673_22725	COG4172	Belongs to the ABC transporter superfamily
M673_22730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_22735	COG0601	transmembrane transport
M673_22740	COG0747	negative chemotaxis
M673_22745	COG1802	Transcriptional regulator
M673_22760	COG1012	belongs to the aldehyde dehydrogenase family
M673_22770	COG0725	ABC transporter, periplasmic molybdate-binding protein
M673_22775	COG1733	regulation of RNA biosynthetic process
M673_22780	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
M673_22785	COG1956	GAF domain-containing protein
M673_22820	COG1129	ABC transporter
M673_22825	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_22830	COG1172	Belongs to the binding-protein-dependent transport system permease family
M673_22850	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M673_22855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M673_22875	COG0559	Belongs to the binding-protein-dependent transport system permease family
M673_22880	COG0410	ABC transporter
M673_22890	COG1984	allophanate hydrolase subunit 2
M673_22900	COG0439	Biotin carboxylase
M673_22910	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M673_22915	COG0583	DNA-binding transcription factor activity
M673_22925	COG4172	Belongs to the ABC transporter superfamily
M673_22930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M673_22955	COG2199	diguanylate cyclase activity
M673_22960	COG4957	zinc ion binding
M673_22965	COG0840	transmembrane signaling receptor activity
M673_22985	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M673_22995	COG1028	Short-chain dehydrogenase reductase Sdr
M673_23000	COG1309	transcriptional regulator
M673_23130	COG4774	siderophore transport
M673_23135	COG2819	hydrolase of the alpha beta superfamily
M673_23140	COG3300	MHYT domain
M673_23140	COG5001	Diguanylate cyclase
M673_23167	COG1396	sequence-specific DNA binding
M673_23230	COG1396	sequence-specific DNA binding
M673_23265	COG0492	ferredoxin-NADP+ reductase activity
M673_23270	COG5001	Diguanylate cyclase
M673_23270	COG3300	MHYT domain
M673_23295	COG0300	oxidoreductase activity
M673_23335	COG2226	methyltransferase
M673_23345	COG0583	DNA-binding transcription factor activity
M673_23350	COG2249	NAD(P)H dehydrogenase (quinone) activity
M673_23355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M673_23365	COG4191	Histidine kinase
M673_23365	COG0784	Response regulator, receiver
M673_23370	COG3920	Histidine kinase
M673_23375	COG4191	Histidine kinase
M673_23375	COG0784	Response regulator, receiver
M673_23430	COG3300	MHYT domain
M673_23430	COG5001	Diguanylate cyclase
M673_23435	COG3706	GGDEF domain
M673_23440	COG5001	Diguanylate cyclase
M673_23445	COG2963	transposase activity
M673_23450	COG3436	PFAM IS66 Orf2 family protein
M673_23455	COG2433	Pfam Transposase IS66
M673_23475	COG0840	transmembrane signaling receptor activity
M673_23480	COG2205	protein histidine kinase activity
M673_23480	COG0784	Response regulator, receiver
M673_23485	COG0784	Response regulator, receiver
M673_23490	COG3920	Histidine kinase
M673_23490	COG2202	Pas domain
M673_23505	COG5001	Diguanylate cyclase
M673_23505	COG3300	MHYT domain
M673_23515	COG3335	DDE superfamily endonuclease
M673_23535	COG1192	Involved in chromosome partitioning
M673_23547	COG4691	Plasmid stability protein
M673_23548	COG1487	ribonuclease activity
M673_23647	COG1396	sequence-specific DNA binding
M673_23690	COG0840	transmembrane signaling receptor activity
M673_23700	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M673_23710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M673_23735	COG2433	Pfam Transposase IS66
M673_23740	COG3436	PFAM IS66 Orf2 family protein
M673_23745	COG2963	transposase activity
M673_23762	COG1216	Glycosyl transferase, family 2
M673_23762	COG0438	transferase activity, transferring glycosyl groups
M673_23805	COG3391	amine dehydrogenase activity
M673_23825	COG0583	DNA-binding transcription factor activity
M673_23850	COG0784	Response regulator, receiver
M673_23850	COG4191	Histidine kinase
M673_23855	COG2202	Pas domain
M673_23855	COG3920	Histidine kinase
M673_23860	COG4191	Histidine kinase
M673_23860	COG0784	Response regulator, receiver
M673_23880	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M673_23900	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
M673_23915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M673_24070	COG0784	Response regulator, receiver
M673_24070	COG4191	Histidine kinase
M673_24077	COG3692	DNA binding