locus-tag	class	description
IGS74_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IGS74_00045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IGS74_00055	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IGS74_00060	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS74_00065	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IGS74_00070	COG2086	electron transfer activity
IGS74_00075	COG2096	Adenosyltransferase
IGS74_00095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IGS74_00115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IGS74_00120	COG4251	negative regulation of phosphorylation
IGS74_00125	COG0784	Response regulator, receiver
IGS74_00130	COG2204	response regulator
IGS74_00145	COG0596	Alpha beta hydrolase
IGS74_00150	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IGS74_00155	COG1674	ftsk spoiiie
IGS74_00165	COG0004	ammonium transporteR
IGS74_00170	COG0347	Belongs to the P(II) protein family
IGS74_00175	COG0004	ammonium transporteR
IGS74_00180	COG0347	Belongs to the P(II) protein family
IGS74_00185	COG1946	Acyl-CoA thioesterase
IGS74_00190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IGS74_00200	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IGS74_00210	COG0175	sulfate reduction
IGS74_00215	COG0175	sulfate reduction
IGS74_00220	COG2895	sulfate adenylyltransferase (ATP) activity
IGS74_00225	COG2835	tetraacyldisaccharide 4'-kinase activity
IGS74_00230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IGS74_00270	COG1376	ErfK ybiS ycfS ynhG family protein
IGS74_00325	COG0656	L-ascorbic acid biosynthetic process
IGS74_00335	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IGS74_00340	COG1238	metal cluster binding
IGS74_00350	COG1414	Transcriptional regulator
IGS74_00370	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IGS74_00385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IGS74_00395	COG1388	LysM domain
IGS74_00395	COG1376	ErfK ybiS ycfS ynhG family protein
IGS74_00435	COG1280	lysine exporter protein (LysE YggA)
IGS74_00465	COG4716	Myosin-crossreactive antigen
IGS74_00470	COG1024	Enoyl-CoA hydratase
IGS74_00470	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS74_00475	COG1309	transcriptional regulator
IGS74_00500	COG0842	Transport permease protein
IGS74_00505	COG0842	Transport permease protein
IGS74_00515	COG1309	transcriptional regulator
IGS74_00535	COG0642	Histidine kinase
IGS74_00540	COG1376	ErfK ybiS ycfS ynhG family protein
IGS74_00560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IGS74_00575	COG1937	Protein conserved in bacteria
IGS74_00610	COG0789	Transcriptional regulator
IGS74_00620	COG2010	Cytochrome c
IGS74_00630	COG2132	Multicopper oxidase
IGS74_00660	COG1238	metal cluster binding
IGS74_00675	COG1230	cation diffusion facilitator family transporter
IGS74_00680	COG0640	Transcriptional regulator
IGS74_00690	COG0583	DNA-binding transcription factor activity
IGS74_00700	COG2948	multi-organism process
IGS74_00715	COG3846	protein secretion by the type IV secretion system
IGS74_00730	COG3451	type IV secretory pathway VirB4
IGS74_00745	COG4962	Type ii secretion system protein e
IGS74_00760	COG0789	Transcriptional regulator
IGS74_00770	COG1230	cation diffusion facilitator family transporter
IGS74_00780	COG1999	signal sequence binding
IGS74_00785	COG0785	Cytochrome C biogenesis protein
IGS74_00800	COG0640	Transcriptional regulator
IGS74_00815	COG0798	PFAM Bile acid sodium symporter
IGS74_00820	COG0431	NADPH-dependent FMN reductase
IGS74_00855	COG0741	lytic transglycosylase activity
IGS74_00885	COG1192	Involved in chromosome partitioning
IGS74_00915	COG0629	single-stranded DNA binding
IGS74_01005	COG1475	DNA binding
IGS74_01020	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IGS74_01025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IGS74_01050	COG4227	nucleotidyltransferase activity
IGS74_01070	COG4974	Belongs to the 'phage' integrase family
IGS74_01120	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IGS74_01125	COG0459	protein refolding
IGS74_01210	COG0318	PFAM AMP-dependent synthetase and ligase
IGS74_01215	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IGS74_01220	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IGS74_01225	COG2813	Specifically methylates the guanine in position
IGS74_01230	COG1187	pseudouridine synthase activity
IGS74_01235	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IGS74_01245	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IGS74_01250	COG1704	LemA family
IGS74_01260	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IGS74_01280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IGS74_01285	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IGS74_01285	COG2010	Cytochrome c
IGS74_01295	COG0765	amino acid transport
IGS74_01300	COG0765	amino acid transport
IGS74_01310	COG1126	abc transporter atp-binding protein
IGS74_01315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IGS74_01325	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IGS74_01335	COG1960	acyl-CoA dehydrogenase activity
IGS74_01340	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IGS74_01355	COG1024	Enoyl-CoA hydratase
IGS74_01370	COG1022	Amp-dependent synthetase and ligase
IGS74_01375	COG0559	Belongs to the binding-protein-dependent transport system permease family
IGS74_01390	COG0410	ABC transporter
IGS74_01395	COG0318	PFAM AMP-dependent synthetase and ligase
IGS74_01400	COG2169	Transcriptional regulator
IGS74_01400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IGS74_01415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IGS74_01415	COG0045	succinate-CoA ligase (ADP-forming) activity
IGS74_01415	COG1042	CoA-binding domain protein
IGS74_01420	COG0346	lactoylglutathione lyase activity
IGS74_01440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IGS74_01445	COG0028	Belongs to the TPP enzyme family
IGS74_01480	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IGS74_01480	COG0517	IMP dehydrogenase activity
IGS74_01480	COG0617	tRNA 3'-terminal CCA addition
IGS74_01485	COG3276	selenocysteine insertion sequence binding
IGS74_01490	COG1921	L-seryl-tRNASec selenium transferase activity
IGS74_01500	COG2864	formate dehydrogenase
IGS74_01505	COG0437	4 iron, 4 sulfur cluster binding
IGS74_01525	COG1846	Transcriptional regulator
IGS74_01545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS74_01570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGS74_01575	COG1012	belongs to the aldehyde dehydrogenase family
IGS74_01590	COG2985	domain, Protein
IGS74_01600	COG1301	dicarboxylic acid transport
IGS74_01605	COG4191	Histidine kinase
IGS74_01610	COG2204	response regulator
IGS74_01620	COG1879	ABC-type sugar transport system periplasmic component
IGS74_01625	COG1129	ABC transporter
IGS74_01630	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS74_01635	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS74_01645	COG0436	Aminotransferase
IGS74_01660	COG3842	ATPase activity
IGS74_01665	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGS74_01670	COG1177	transmembrane transport
IGS74_01685	COG4993	Dehydrogenase
IGS74_01695	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IGS74_01705	COG0783	Belongs to the Dps family
IGS74_01710	COG3608	succinylglutamate desuccinylase aspartoacylase
IGS74_01715	COG0006	proline dipeptidase activity
IGS74_01720	COG2423	ornithine cyclodeaminase activity
IGS74_01725	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IGS74_01735	COG0765	amino acid transport
IGS74_01740	COG0765	amino acid transport
IGS74_01750	COG1126	abc transporter atp-binding protein
IGS74_01755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS74_01760	COG1522	sequence-specific DNA binding
IGS74_01770	COG1012	belongs to the aldehyde dehydrogenase family
IGS74_01775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IGS74_01780	COG0784	Response regulator, receiver
IGS74_01800	COG3246	L-lysine catabolic process to acetate
IGS74_01805	COG0824	Thioesterase
IGS74_01805	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS74_01810	COG2186	Transcriptional regulator
IGS74_01820	COG1228	amidohydrolase
IGS74_01825	COG2986	histidine ammonia-lyase
IGS74_01835	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IGS74_01880	COG1764	response to oxidative stress
IGS74_01895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IGS74_01905	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_01910	COG0508	dehydrogenase complex catalyzes the overall conversion of
IGS74_01915	COG0567	Dehydrogenase, E1 component
IGS74_01920	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IGS74_01925	COG0045	succinate-CoA ligase (ADP-forming) activity
IGS74_01930	COG0039	L-malate dehydrogenase activity
IGS74_01935	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IGS74_01940	COG2845	Protein of unknown function (DUF459)
IGS74_01945	COG0288	reversible hydration of carbon dioxide
IGS74_01950	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
IGS74_01960	COG2902	Dehydrogenase
IGS74_01965	COG0138	bifunctional purine biosynthesis protein purh
IGS74_01980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IGS74_01980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IGS74_01985	COG0501	Belongs to the peptidase M48B family
IGS74_02000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IGS74_02020	COG3030	protein affecting phage T7 exclusion by the F plasmid
IGS74_02025	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IGS74_02030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IGS74_02035	COG0237	dephospho-CoA kinase activity
IGS74_02045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IGS74_02050	COG0424	maF-like protein
IGS74_02055	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IGS74_02060	COG1981	membrane
IGS74_02065	COG3265	gluconokinase activity
IGS74_02070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IGS74_02080	COG0445	tRNA wobble uridine modification
IGS74_02110	COG0495	leucyl-tRNA aminoacylation
IGS74_02125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IGS74_02130	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IGS74_02170	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IGS74_02175	COG1088	dTDP-glucose 4,6-dehydratase activity
IGS74_02180	COG1091	dTDP-4-dehydrorhamnose reductase activity
IGS74_02185	COG0438	transferase activity, transferring glycosyl groups
IGS74_02210	COG0438	transferase activity, transferring glycosyl groups
IGS74_02210	COG1216	Glycosyl transferase, family 2
IGS74_02220	COG2801	Transposase and inactivated derivatives
IGS74_02250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS74_02265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IGS74_02265	COG0546	phosphoglycolate phosphatase activity
IGS74_02275	COG2814	Major facilitator Superfamily
IGS74_02280	COG2885	chlorophyll binding
IGS74_02285	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IGS74_02290	COG0477	Major facilitator Superfamily
IGS74_02295	COG0473	3-isopropylmalate dehydrogenase activity
IGS74_02300	COG0066	3-isopropylmalate dehydratase activity
IGS74_02330	COG0587	DNA-directed DNA polymerase activity
IGS74_02350	COG0789	Transcriptional regulator
IGS74_02365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IGS74_02385	COG1215	transferase activity, transferring glycosyl groups
IGS74_02395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IGS74_02405	COG2133	pyrroloquinoline quinone binding
IGS74_02410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IGS74_02415	COG2197	response regulator
IGS74_02420	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IGS74_02430	COG0140	phosphoribosyl-ATP diphosphatase activity
IGS74_02435	COG0107	imidazoleglycerol-phosphate synthase activity
IGS74_02440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IGS74_02445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IGS74_02455	COG0131	Imidazoleglycerol-phosphate dehydratase
IGS74_02475	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IGS74_02485	COG0539	negative regulation of cytoplasmic translation
IGS74_02500	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IGS74_02510	COG2113	Glycine betaine
IGS74_02530	COG0438	transferase activity, transferring glycosyl groups
IGS74_02555	COG4558	Periplasmic binding protein
IGS74_02560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS74_02565	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IGS74_02610	COG1376	ErfK ybiS ycfS ynhG family protein
IGS74_02610	COG1388	LysM domain
IGS74_02620	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IGS74_02625	COG1643	Atp-dependent helicase
IGS74_02630	COG4134	Bacterial extracellular solute-binding protein
IGS74_02635	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_02650	COG3181	Tripartite tricarboxylate transporter family receptor
IGS74_02655	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IGS74_02660	COG0443	Heat shock 70 kDa protein
IGS74_02665	COG0484	heat shock protein binding
IGS74_02670	COG3963	phosphatidate phosphatase activity
IGS74_02675	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IGS74_02680	COG0285	dihydrofolate synthase activity
IGS74_02690	COG0159	tryptophan synthase activity
IGS74_02695	COG0133	tryptophan synthase activity
IGS74_02725	COG0284	orotidine-5'-phosphate decarboxylase activity
IGS74_02730	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IGS74_02730	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IGS74_02740	COG3621	Patatin-like phospholipase
IGS74_02745	COG0071	Belongs to the small heat shock protein (HSP20) family
IGS74_02750	COG0071	Belongs to the small heat shock protein (HSP20) family
IGS74_02770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGS74_02785	COG0655	NAD(P)H dehydrogenase (quinone) activity
IGS74_02800	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGS74_02805	COG1280	lysine exporter protein (LysE YggA)
IGS74_02810	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGS74_02815	COG1595	DNA-templated transcription, initiation
IGS74_02825	COG1335	isochorismatase
IGS74_02835	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_02835	COG0604	alcohol dehydrogenase
IGS74_02835	COG3321	synthase
IGS74_02850	COG1741	Belongs to the pirin family
IGS74_02865	COG3773	Cell wall hydrolase
IGS74_02875	COG0351	phosphomethylpyrimidine kinase
IGS74_02880	COG3158	transport of potassium into the cell
IGS74_02895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS74_02915	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_02915	COG3321	synthase
IGS74_02915	COG0604	alcohol dehydrogenase
IGS74_02920	COG3842	ATPase activity
IGS74_02935	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IGS74_02940	COG0583	DNA-binding transcription factor activity
IGS74_02975	COG3181	Tripartite tricarboxylate transporter family receptor
IGS74_02985	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
IGS74_02990	COG0511	ligase activity, forming carbon-carbon bonds
IGS74_02995	COG0439	Biotin carboxylase
IGS74_03010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IGS74_03015	COG4948	Mandelate Racemase Muconate Lactonizing
IGS74_03020	COG2301	Belongs to the HpcH HpaI aldolase family
IGS74_03035	COG0765	amino acid transport
IGS74_03040	COG0765	amino acid transport
IGS74_03055	COG3608	succinylglutamate desuccinylase aspartoacylase
IGS74_03060	COG1609	Transcriptional regulator
IGS74_03085	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS74_03090	COG1129	ABC transporter
IGS74_03095	COG1879	ABC-type sugar transport system periplasmic component
IGS74_03100	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IGS74_03105	COG3608	succinylglutamate desuccinylase aspartoacylase
IGS74_03120	COG0419	ATPase involved in DNA repair
IGS74_03135	COG0583	DNA-binding transcription factor activity
IGS74_03140	COG0006	proline dipeptidase activity
IGS74_03145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS74_03155	COG1116	anion transmembrane transporter activity
IGS74_03165	COG0405	Gamma-glutamyltransferase
IGS74_03175	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IGS74_03185	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_03190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS74_03195	COG4172	Belongs to the ABC transporter superfamily
IGS74_03200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS74_03205	COG0601	transmembrane transport
IGS74_03210	COG0747	negative chemotaxis
IGS74_03215	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IGS74_03255	COG1126	abc transporter atp-binding protein
IGS74_03265	COG0765	amino acid transport
IGS74_03275	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IGS74_03290	COG3842	ATPase activity
IGS74_03295	COG1175	transmembrane transport
IGS74_03300	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IGS74_03315	COG0287	Prephenate dehydrogenase
IGS74_03315	COG1605	Chorismate mutase
IGS74_03355	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IGS74_03370	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IGS74_03375	COG2197	response regulator
IGS74_03380	COG2094	Belongs to the DNA glycosylase MPG family
IGS74_03400	COG0747	negative chemotaxis
IGS74_03405	COG0601	transmembrane transport
IGS74_03410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS74_03415	COG0444	Belongs to the ABC transporter superfamily
IGS74_03420	COG4608	Belongs to the ABC transporter superfamily
IGS74_03430	COG3618	amidohydrolase
IGS74_03445	COG4214	carbohydrate transport
IGS74_03450	COG1129	ABC transporter
IGS74_03465	COG1215	transferase activity, transferring glycosyl groups
IGS74_03475	COG3119	arylsulfatase activity
IGS74_03485	COG1175	transmembrane transport
IGS74_03490	COG0395	ABC-type sugar transport system, permease component
IGS74_03495	COG3842	ATPase activity
IGS74_03510	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
IGS74_03515	COG0800	Aldolase
IGS74_03530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IGS74_03535	COG1609	Transcriptional regulator
IGS74_03545	COG0523	cobalamin synthesis protein
IGS74_03555	COG3920	Histidine kinase
IGS74_03555	COG2202	Pas domain
IGS74_03570	COG0753	catalase activity
IGS74_03575	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IGS74_03575	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IGS74_03610	COG2948	multi-organism process
IGS74_03620	COG3701	Conjugal transfer protein
IGS74_03735	COG0583	DNA-binding transcription factor activity
IGS74_03770	COG0625	glutathione transferase activity
IGS74_03780	COG0596	Alpha beta hydrolase
IGS74_03785	COG1309	transcriptional regulator
IGS74_03790	COG1309	transcriptional regulator
IGS74_03810	COG4221	oxidoreductase activity
IGS74_03820	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_03830	COG4221	oxidoreductase activity
IGS74_03865	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
IGS74_03870	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
IGS74_03880	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_03890	COG0583	DNA-binding transcription factor activity
IGS74_03895	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_03905	COG0475	glutathione-regulated potassium exporter activity
IGS74_03905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IGS74_03930	COG0583	DNA-binding transcription factor activity
IGS74_03940	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_03945	COG1902	pentaerythritol trinitrate reductase activity
IGS74_03965	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_03985	COG0604	alcohol dehydrogenase
IGS74_04050	COG2186	Transcriptional regulator
IGS74_04055	COG1802	Transcriptional regulator
IGS74_04060	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IGS74_04070	COG2376	Dihydroxyacetone kinase
IGS74_04095	COG4453	Protein conserved in bacteria
IGS74_04100	COG0583	DNA-binding transcription factor activity
IGS74_04105	COG0667	Aldo Keto reductase
IGS74_04115	COG0579	oxidoreductase
IGS74_04135	COG2072	flavoprotein involved in K transport
IGS74_04140	COG3842	ATPase activity
IGS74_04145	COG1177	transmembrane transport
IGS74_04150	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGS74_04165	COG2223	nitrite transmembrane transporter activity
IGS74_04170	COG0287	Prephenate dehydrogenase
IGS74_04175	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IGS74_04185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IGS74_04190	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IGS74_04190	COG2813	Specifically methylates the guanine in position
IGS74_04195	COG0667	Aldo Keto reductase
IGS74_04205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGS74_04215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IGS74_04220	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IGS74_04255	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IGS74_04260	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IGS74_04295	COG0653	protein targeting
IGS74_04300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IGS74_04305	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IGS74_04315	COG0494	nUDIX hydrolase
IGS74_04325	COG2226	methyltransferase
IGS74_04330	COG1040	competence protein
IGS74_04335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IGS74_04340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGS74_04385	COG1175	transmembrane transport
IGS74_04400	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_04405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IGS74_04410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS74_04415	COG4521	taurine ABC transporter
IGS74_04420	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
IGS74_04425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS74_04445	COG0745	RESPONSE REGULATOR receiver
IGS74_04455	COG0243	molybdopterin cofactor binding
IGS74_04460	COG2264	protein methyltransferase activity
IGS74_04480	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IGS74_04485	COG0181	hydroxymethylbilane synthase activity
IGS74_04510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IGS74_04530	COG3685	Protein conserved in bacteria
IGS74_04545	COG0328	RNA-DNA hybrid ribonuclease activity
IGS74_04555	COG4974	Belongs to the 'phage' integrase family
IGS74_04605	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IGS74_04610	COG2011	ABC-type metal ion transport system permease component
IGS74_04615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IGS74_04625	COG1217	gtp-binding protein TYPA
IGS74_04640	COG2814	Major facilitator Superfamily
IGS74_04645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS74_04650	COG0137	argininosuccinate synthase activity
IGS74_04670	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IGS74_04685	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IGS74_04695	COG4181	ATPase activity
IGS74_04700	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IGS74_04705	COG0670	Belongs to the BI1 family
IGS74_04725	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IGS74_04730	COG4133	protoheme IX ABC transporter activity
IGS74_04735	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IGS74_04745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IGS74_04755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IGS74_04760	COG1126	abc transporter atp-binding protein
IGS74_04765	COG0765	amino acid transport
IGS74_04770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS74_04775	COG2271	Major facilitator Superfamily
IGS74_04785	COG2917	probably involved in intracellular septation
IGS74_04790	COG0552	protein localization to endoplasmic reticulum
IGS74_04795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IGS74_04800	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IGS74_04810	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IGS74_04815	COG0228	four-way junction DNA binding
IGS74_04820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IGS74_04825	COG0336	Belongs to the RNA methyltransferase TrmD family
IGS74_04830	COG0335	large ribosomal subunit rRNA binding
IGS74_04845	COG2009	succinate dehydrogenase
IGS74_04850	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
IGS74_04855	COG1053	succinate dehydrogenase
IGS74_04880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGS74_04890	COG0783	Belongs to the Dps family
IGS74_04905	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IGS74_04910	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IGS74_04915	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IGS74_04920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IGS74_04925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IGS74_04940	COG0494	nUDIX hydrolase
IGS74_04945	COG0793	Belongs to the peptidase S41A family
IGS74_04955	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IGS74_04960	COG0799	negative regulation of ribosome biogenesis
IGS74_04965	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IGS74_04970	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IGS74_04985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IGS74_04990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IGS74_05025	COG4178	(ABC) transporter
IGS74_05040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IGS74_05045	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IGS74_05050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IGS74_05055	COG1802	Transcriptional regulator
IGS74_05060	COG1312	Catalyzes the dehydration of D-mannonate
IGS74_05070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGS74_05075	COG1309	transcriptional regulator
IGS74_05085	COG3842	ATPase activity
IGS74_05090	COG1175	transmembrane transport
IGS74_05095	COG0395	ABC-type sugar transport system, permease component
IGS74_05105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IGS74_05110	COG0387	Pfam Sodium calcium exchanger
IGS74_05115	COG3181	Tripartite tricarboxylate transporter family receptor
IGS74_05130	COG1414	Transcriptional regulator
IGS74_05135	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS74_05140	COG0765	amino acid transport
IGS74_05145	COG1126	abc transporter atp-binding protein
IGS74_05150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS74_05165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGS74_05170	COG0577	efflux transmembrane transporter activity
IGS74_05170	COG1136	(ABC) transporter
IGS74_05175	COG3177	Filamentation induced by cAMP protein fic
IGS74_05180	COG0438	transferase activity, transferring glycosyl groups
IGS74_05185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IGS74_05190	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IGS74_05195	COG0505	Belongs to the CarA family
IGS74_05205	COG0358	DNA primase activity
IGS74_05210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IGS74_05235	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS74_05240	COG1129	ABC transporter
IGS74_05245	COG1879	ABC-type sugar transport system periplasmic component
IGS74_05255	COG2197	response regulator
IGS74_05285	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS74_05290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS74_05290	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IGS74_05300	COG0642	Histidine kinase
IGS74_05305	COG0745	RESPONSE REGULATOR receiver
IGS74_05320	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGS74_05335	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IGS74_05340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IGS74_05345	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IGS74_05350	COG1137	ATPase activity
IGS74_05365	COG0616	signal peptide processing
IGS74_05385	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IGS74_05395	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IGS74_05410	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IGS74_05415	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IGS74_05425	COG0180	Tryptophanyl-tRNA synthetase
IGS74_05435	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IGS74_05440	COG1214	PFAM Peptidase M22, glycoprotease
IGS74_05475	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IGS74_05480	COG1396	sequence-specific DNA binding
IGS74_05485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IGS74_05490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IGS74_05495	COG0779	Required for maturation of 30S ribosomal subunits
IGS74_05515	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IGS74_05525	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IGS74_05530	COG1185	polyribonucleotide nucleotidyltransferase activity
IGS74_05535	COG1185	polyribonucleotide nucleotidyltransferase activity
IGS74_05540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IGS74_05545	COG0165	Argininosuccinate lyase
IGS74_05570	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IGS74_05580	COG2884	Cell division ATP-binding protein ftsE
IGS74_05680	COG2354	Protein conserved in bacteria
IGS74_05700	COG1131	(ABC) transporter
IGS74_05715	COG2197	response regulator
IGS74_05720	COG4585	Histidine kinase
IGS74_05750	COG2233	PERMEase
IGS74_05765	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
IGS74_05775	COG0189	ligase activity
IGS74_05790	COG0702	epimerase
IGS74_05805	COG1229	Formylmethanofuran dehydrogenase subunit A
IGS74_05810	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
IGS74_05815	COG2218	PFAM glutamate synthase alpha subunit domain protein
IGS74_05860	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IGS74_05875	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS74_05885	COG3845	ABC transporter
IGS74_05890	COG4603	Belongs to the binding-protein-dependent transport system permease family
IGS74_05895	COG1079	Belongs to the binding-protein-dependent transport system permease family
IGS74_05905	COG0402	S-adenosylhomocysteine deaminase activity
IGS74_05925	COG0366	Alpha amylase catalytic
IGS74_05930	COG0366	Alpha amylase catalytic
IGS74_05935	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IGS74_05945	COG1473	amidohydrolase
IGS74_05950	COG1686	Belongs to the peptidase S11 family
IGS74_05955	COG0523	cobalamin synthesis protein
IGS74_05960	COG0425	Belongs to the sulfur carrier protein TusA family
IGS74_05975	COG0400	carboxylic ester hydrolase activity
IGS74_05980	COG0604	alcohol dehydrogenase
IGS74_05995	COG0318	PFAM AMP-dependent synthetase and ligase
IGS74_06010	COG2968	Membrane
IGS74_06030	COG0477	Major facilitator Superfamily
IGS74_06060	COG0583	DNA-binding transcription factor activity
IGS74_06075	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IGS74_06080	COG1175	transmembrane transport
IGS74_06085	COG0395	ABC-type sugar transport system, permease component
IGS74_06090	COG2390	Transcriptional regulator
IGS74_06095	COG3842	ATPase activity
IGS74_06110	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IGS74_06115	COG1132	(ABC) transporter
IGS74_06130	COG2857	Cytochrome c1
IGS74_06130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IGS74_06155	COG2030	dehydratase
IGS74_06160	COG0012	GTP binding
IGS74_06165	COG0193	aminoacyl-tRNA hydrolase activity
IGS74_06170	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IGS74_06180	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IGS74_06200	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IGS74_06220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IGS74_06230	COG0745	RESPONSE REGULATOR receiver
IGS74_06235	COG1846	Transcriptional regulator
IGS74_06245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IGS74_06250	COG1278	Cold shock
IGS74_06260	COG0556	nucleotide-excision repair
IGS74_06290	COG0436	Aminotransferase
IGS74_06295	COG0583	DNA-binding transcription factor activity
IGS74_06300	COG0492	ferredoxin-NADP+ reductase activity
IGS74_06305	COG5265	(ABC) transporter
IGS74_06310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IGS74_06325	COG4251	negative regulation of phosphorylation
IGS74_06335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS74_06340	COG0174	glutamine synthetase
IGS74_06350	COG2224	Isocitrate lyase
IGS74_06355	COG3800	Transcriptional regulator
IGS74_06355	COG1396	sequence-specific DNA binding
IGS74_06375	COG3842	ATPase activity
IGS74_06380	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGS74_06385	COG1177	transmembrane transport
IGS74_06400	COG2205	protein histidine kinase activity
IGS74_06420	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_06430	COG3706	GGDEF domain
IGS74_06435	COG0438	transferase activity, transferring glycosyl groups
IGS74_06445	COG1570	exodeoxyribonuclease VII activity
IGS74_06450	COG0583	DNA-binding transcription factor activity
IGS74_06465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS74_06480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IGS74_06485	COG0583	DNA-binding transcription factor activity
IGS74_06490	COG1253	flavin adenine dinucleotide binding
IGS74_06510	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_06530	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IGS74_06535	COG0277	FAD linked oxidase domain protein
IGS74_06540	COG0277	FAD linked oxidase domain protein
IGS74_06545	COG0247	lactate metabolic process
IGS74_06550	COG1376	ErfK ybiS ycfS ynhG family protein
IGS74_06585	COG0300	oxidoreductase activity
IGS74_06600	COG4774	siderophore transport
IGS74_06605	COG5507	3-demethylubiquinone-9 3-methyltransferase
IGS74_06620	COG1660	Displays ATPase and GTPase activities
IGS74_06635	COG4221	oxidoreductase activity
IGS74_06640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IGS74_06655	COG3046	protein related to deoxyribodipyrimidine photolyase
IGS74_06665	COG0251	oxidation-reduction process
IGS74_06680	COG2818	Glycosylase
IGS74_06690	COG0124	histidyl-tRNA synthetase
IGS74_06695	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IGS74_06700	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IGS74_06710	COG2259	Doxx family
IGS74_06725	COG0459	protein refolding
IGS74_06740	COG0196	riboflavin kinase activity
IGS74_06745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IGS74_06755	COG0590	tRNA wobble adenosine to inosine editing
IGS74_06760	COG1187	pseudouridine synthase activity
IGS74_06765	COG0742	ribosomal rna small subunit methyltransferase
IGS74_06770	COG0612	Peptidase, M16
IGS74_06775	COG0612	Peptidase, M16
IGS74_06780	COG1752	Esterase of the alpha-beta hydrolase superfamily
IGS74_06795	COG0312	modulator of DNA gyrase
IGS74_06800	COG0483	inositol monophosphate 1-phosphatase activity
IGS74_06815	COG1519	Transferase
IGS74_06820	COG1663	tetraacyldisaccharide 4'-kinase activity
IGS74_06825	COG1064	alcohol dehydrogenase
IGS74_06860	COG1523	belongs to the glycosyl hydrolase 13 family
IGS74_06870	COG0033	Phosphoglucomutase
IGS74_06875	COG0297	glycogen (starch) synthase activity
IGS74_06880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IGS74_06885	COG0058	SHG alpha-glucan phosphorylase activity
IGS74_06890	COG0166	Belongs to the GPI family
IGS74_06905	COG0729	surface antigen
IGS74_06925	COG1294	oxidase, subunit
IGS74_06930	COG1271	oxidase subunit
IGS74_06955	COG1562	ergosterol biosynthetic process
IGS74_06970	COG1304	FMN binding
IGS74_06975	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IGS74_06995	COG3833	ABC-type maltose transport systems, permease component
IGS74_07005	COG3842	ATPase activity
IGS74_07015	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IGS74_07020	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IGS74_07025	COG4208	sulfate ABC transporter
IGS74_07030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IGS74_07040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGS74_07055	COG0251	oxidation-reduction process
IGS74_07075	COG2824	Alkylphosphonate utilization operon protein PhnA
IGS74_07080	COG1280	lysine exporter protein (LysE YggA)
IGS74_07090	COG2847	Copper chaperone PCu(A)C
IGS74_07100	COG2066	Belongs to the glutaminase family
IGS74_07110	COG0667	Aldo Keto reductase
IGS74_07140	COG0803	Belongs to the bacterial solute-binding protein 9 family
IGS74_07145	COG1121	(ABC) transporter
IGS74_07150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IGS74_07150	COG1321	iron dependent repressor
IGS74_07155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IGS74_07170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS74_07175	COG4948	Mandelate Racemase Muconate Lactonizing
IGS74_07180	COG0277	FAD linked oxidase domain protein
IGS74_07185	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IGS74_07205	COG4451	ribulose bisphosphate carboxylase, small
IGS74_07225	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IGS74_07230	COG0583	DNA-binding transcription factor activity
IGS74_07235	COG0248	Ppx GppA phosphatase
IGS74_07240	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IGS74_07245	COG0477	Major facilitator Superfamily
IGS74_07255	COG0385	Bile acid
IGS74_07265	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IGS74_07300	COG0583	DNA-binding transcription factor activity
IGS74_07315	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
IGS74_07365	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IGS74_07385	COG1830	Aldolase
IGS74_07400	COG0784	Response regulator, receiver
IGS74_07400	COG4191	Histidine kinase
IGS74_07405	COG2202	Pas domain
IGS74_07405	COG3920	Histidine kinase
IGS74_07410	COG0789	Transcriptional regulator
IGS74_07420	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IGS74_07440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IGS74_07445	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IGS74_07455	COG0535	radical SAM domain protein
IGS74_07460	COG0598	Magnesium transport protein CorA
IGS74_07470	COG0433	COG0433 Predicted ATPase
IGS74_07475	COG1376	ErfK ybiS ycfS ynhG family protein
IGS74_07485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IGS74_07495	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGS74_07500	COG2111	Na H antiporter
IGS74_07500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IGS74_07505	COG2111	Na H antiporter
IGS74_07510	COG1006	Multisubunit Na H antiporter MnhC subunit
IGS74_07515	COG0651	ATP synthesis coupled electron transport
IGS74_07520	COG1863	multisubunit Na H antiporter MnhE subunit
IGS74_07525	COG2212	antiporter activity
IGS74_07530	COG1320	monovalent cation:proton antiporter activity
IGS74_07535	COG1218	3'(2'),5'-bisphosphate nucleotidase
IGS74_07550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IGS74_07555	COG0493	'glutamate synthase
IGS74_07565	COG1309	transcriptional regulator
IGS74_07585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS74_07590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS74_07615	COG0513	Belongs to the DEAD box helicase family
IGS74_07620	COG0488	(ABC) transporter
IGS74_07625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IGS74_07630	COG1566	PFAM secretion protein HlyD family protein
IGS74_07640	COG5487	UPF0391 membrane protein
IGS74_07680	COG0784	Response regulator, receiver
IGS74_07685	COG2202	Pas domain
IGS74_07685	COG3920	Histidine kinase
IGS74_07700	COG0489	protein tyrosine kinase activity
IGS74_07710	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IGS74_07715	COG0494	nUDIX hydrolase
IGS74_07720	COG4172	Belongs to the ABC transporter superfamily
IGS74_07725	COG4239	(ABC) transporter, permease
IGS74_07730	COG4174	ABC transporter (Permease)
IGS74_07735	COG4166	transmembrane transport
IGS74_07740	COG4166	transmembrane transport
IGS74_07745	COG3474	cytochrome
IGS74_07750	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IGS74_07770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IGS74_07780	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IGS74_07790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS74_07800	COG0101	tRNA pseudouridine synthase activity
IGS74_07805	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IGS74_07810	COG0242	peptide deformylase activity
IGS74_07815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGS74_07820	COG0659	secondary active sulfate transmembrane transporter activity
IGS74_07830	COG2951	lytic endotransglycosylase activity
IGS74_07835	COG2171	N-acyltransferase activity
IGS74_07855	COG0477	Major facilitator Superfamily
IGS74_07860	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IGS74_07870	COG2084	Dehydrogenase
IGS74_07875	COG3395	kinase activity
IGS74_07880	COG3622	Belongs to the hyi family
IGS74_07885	COG1349	DNA-binding transcription factor activity
IGS74_07890	COG0235	Class ii aldolase
IGS74_07900	COG4120	Belongs to the binding-protein-dependent transport system permease family
IGS74_07910	COG0668	transmembrane transport
IGS74_07915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IGS74_07925	COG0330	HflC and HflK could
IGS74_07935	COG5310	Homospermidine synthase
IGS74_07955	COG4957	zinc ion binding
IGS74_07960	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IGS74_07960	COG0392	lysyltransferase activity
IGS74_08000	COG0745	RESPONSE REGULATOR receiver
IGS74_08015	COG0579	oxidoreductase
IGS74_08020	COG3750	Belongs to the UPF0335 family
IGS74_08035	COG0469	pyruvate kinase activity
IGS74_08040	COG0457	Tetratricopeptide repeat
IGS74_08045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IGS74_08050	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IGS74_08085	COG0483	inositol monophosphate 1-phosphatase activity
IGS74_08115	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IGS74_08120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IGS74_08130	COG2967	ApaG domain
IGS74_08140	COG0717	Belongs to the dCTP deaminase family
IGS74_08150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS74_08165	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_08175	COG1160	GTP binding
IGS74_08190	COG0356	it plays a direct role in the translocation of protons across the membrane
IGS74_08195	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IGS74_08200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IGS74_08205	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IGS74_08210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IGS74_08225	COG0521	Mo-molybdopterin cofactor biosynthetic process
IGS74_08230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IGS74_08240	COG0142	geranyltranstransferase activity
IGS74_08255	COG0616	signal peptide processing
IGS74_08255	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IGS74_08265	COG0752	glycyl-tRNA synthetase alpha subunit
IGS74_08270	COG2321	neutral zinc metallopeptidase
IGS74_08275	COG0751	glycine-tRNA ligase activity
IGS74_08285	COG0009	L-threonylcarbamoyladenylate synthase
IGS74_08300	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IGS74_08310	COG3842	ATPase activity
IGS74_08320	COG1063	alcohol dehydrogenase
IGS74_08330	COG0151	Belongs to the GarS family
IGS74_08335	COG1960	acyl-CoA dehydrogenase activity
IGS74_08345	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS74_08345	COG1024	Enoyl-CoA hydratase
IGS74_08350	COG0583	DNA-binding transcription factor activity
IGS74_08390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IGS74_08395	COG1960	acyl-CoA dehydrogenase activity
IGS74_08400	COG1024	Enoyl-CoA hydratase
IGS74_08405	COG0586	Pfam SNARE associated Golgi protein
IGS74_08410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IGS74_08420	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IGS74_08425	COG1722	exodeoxyribonuclease VII activity
IGS74_08430	COG0123	including yeast histone deacetylase and acetoin utilization protein
IGS74_08435	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IGS74_08450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IGS74_08455	COG0484	heat shock protein binding
IGS74_08465	COG0259	pyridoxamine-phosphate oxidase activity
IGS74_08470	COG0312	modulator of DNA gyrase
IGS74_08485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IGS74_08490	COG0109	protoheme IX farnesyltransferase activity
IGS74_08500	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IGS74_08515	COG3346	SURF1 family
IGS74_08520	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IGS74_08525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IGS74_08530	COG0328	RNA-DNA hybrid ribonuclease activity
IGS74_08545	COG1678	Uncharacterized ACR, COG1678
IGS74_08560	COG0612	Peptidase, M16
IGS74_08575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IGS74_08580	COG2189	Belongs to the N(4) N(6)-methyltransferase family
IGS74_08590	COG1194	a g-specific adenine glycosylase
IGS74_08610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IGS74_08615	COG0574	Belongs to the PEP-utilizing enzyme family
IGS74_08615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IGS74_08630	COG1054	Belongs to the UPF0176 family
IGS74_08635	COG0477	Major facilitator Superfamily
IGS74_08640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGS74_08640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IGS74_08645	COG0861	Integral membrane protein TerC family
IGS74_08650	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IGS74_08655	COG1363	Peptidase, m42
IGS74_08665	COG0367	asparagine synthase
IGS74_08675	COG0546	phosphoglycolate phosphatase activity
IGS74_08680	COG0531	amino acid
IGS74_08695	COG1522	sequence-specific DNA binding
IGS74_08710	COG1268	BioY protein
IGS74_08720	COG0129	dihydroxy-acid dehydratase activity
IGS74_08725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS74_08760	COG4948	Mandelate Racemase Muconate Lactonizing
IGS74_08790	COG1793	dna ligase
IGS74_08805	COG0123	including yeast histone deacetylase and acetoin utilization protein
IGS74_08810	COG0167	dihydroorotate dehydrogenase activity
IGS74_08825	COG1970	mechanosensitive ion channel activity
IGS74_08830	COG0436	Aminotransferase
IGS74_08840	COG0025	NhaP-type Na H and K H
IGS74_08845	COG0156	8-amino-7-oxononanoate synthase activity
IGS74_08860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IGS74_08880	COG0601	transmembrane transport
IGS74_08885	COG0747	negative chemotaxis
IGS74_08905	COG1012	belongs to the aldehyde dehydrogenase family
IGS74_08920	COG1999	signal sequence binding
IGS74_08930	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IGS74_08935	COG1845	cytochrome c oxidase, subunit III
IGS74_08940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IGS74_08945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IGS74_08950	COG0477	Major facilitator Superfamily
IGS74_08955	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IGS74_08960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS74_08985	COG2011	ABC-type metal ion transport system permease component
IGS74_08990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IGS74_08995	COG1464	Belongs to the NlpA lipoprotein family
IGS74_09000	COG0431	NADPH-dependent FMN reductase
IGS74_09005	COG4302	ethanolamine ammonia-lyase activity
IGS74_09010	COG4303	Ethanolamine ammonia lyase large subunit
IGS74_09030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS74_09035	COG4172	Belongs to the ABC transporter superfamily
IGS74_09045	COG0601	transmembrane transport
IGS74_09050	COG0747	negative chemotaxis
IGS74_09055	COG1349	DNA-binding transcription factor activity
IGS74_09060	COG1349	DNA-binding transcription factor activity
IGS74_09065	COG1349	DNA-binding transcription factor activity
IGS74_09075	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IGS74_09110	COG0071	Belongs to the small heat shock protein (HSP20) family
IGS74_09135	COG0067	glutamate synthase
IGS74_09135	COG0069	glutamate synthase activity
IGS74_09135	COG0070	glutamate synthase
IGS74_09145	COG3111	PFAM Bacterial OB fold (BOF) protein
IGS74_09155	COG2951	lytic endotransglycosylase activity
IGS74_09170	COG0346	lactoylglutathione lyase activity
IGS74_09180	COG0848	biopolymer transport protein
IGS74_09205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IGS74_09205	COG2010	Cytochrome c
IGS74_09210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IGS74_09225	COG1012	belongs to the aldehyde dehydrogenase family
IGS74_09260	COG2181	nitrate reductase activity
IGS74_09260	COG0247	lactate metabolic process
IGS74_09265	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGS74_09265	COG1902	pentaerythritol trinitrate reductase activity
IGS74_09275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IGS74_09285	COG1760	l-serine dehydratase
IGS74_09295	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGS74_09295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IGS74_09305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS74_09310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IGS74_09320	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IGS74_09335	COG2022	thiamine diphosphate biosynthetic process
IGS74_09380	COG0586	Pfam SNARE associated Golgi protein
IGS74_09445	COG3023	N-Acetylmuramoyl-L-alanine amidase
IGS74_09460	COG2001	Belongs to the MraZ family
IGS74_09465	COG0275	rRNA processing
IGS74_09480	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IGS74_09490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IGS74_09495	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IGS74_09505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IGS74_09510	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IGS74_09520	COG1181	Belongs to the D-alanine--D-alanine ligase family
IGS74_09525	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IGS74_09530	COG0849	cell division
IGS74_09535	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IGS74_09545	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IGS74_09550	COG0497	DNA recombination
IGS74_09555	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IGS74_09580	COG0006	proline dipeptidase activity
IGS74_09590	COG2264	protein methyltransferase activity
IGS74_09595	COG1999	signal sequence binding
IGS74_09605	COG2814	Major facilitator Superfamily
IGS74_09625	COG0210	DNA helicase
IGS74_09655	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
IGS74_09660	COG4948	Mandelate Racemase Muconate Lactonizing
IGS74_09665	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IGS74_09670	COG1127	ABC transporter
IGS74_09680	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IGS74_09680	COG3218	ABC-type transport auxiliary lipoprotein component
IGS74_09700	COG0633	Ferredoxin
IGS74_09710	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IGS74_09715	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IGS74_09725	COG3768	UPF0283 membrane protein
IGS74_09730	COG3106	COG3106 Predicted ATPase
IGS74_09760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IGS74_09765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS74_09770	COG1686	Belongs to the peptidase S11 family
IGS74_09785	COG0028	Belongs to the TPP enzyme family
IGS74_09790	COG0477	Major facilitator Superfamily
IGS74_09800	COG1414	Transcriptional regulator
IGS74_09810	COG1132	(ABC) transporter
IGS74_09825	COG2855	membrane
IGS74_09855	COG1278	Cold shock
IGS74_09860	COG0346	lactoylglutathione lyase activity
IGS74_09905	COG0671	phosphoesterase, PA-phosphatase related
IGS74_09935	COG3546	catalase activity
IGS74_09945	COG1278	Cold shock
IGS74_09955	COG1960	acyl-CoA dehydrogenase activity
IGS74_09985	COG0601	transmembrane transport
IGS74_09990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS74_10000	COG4608	Belongs to the ABC transporter superfamily
IGS74_10025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS74_10030	COG0601	transmembrane transport
IGS74_10040	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS74_10065	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IGS74_10090	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
IGS74_10100	COG0316	Belongs to the HesB IscA family
IGS74_10110	COG0018	arginyl-trna synthetase
IGS74_10120	COG1472	Belongs to the glycosyl hydrolase 3 family
IGS74_10125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IGS74_10130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IGS74_10135	COG0805	protein transport
IGS74_10150	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IGS74_10165	COG1862	Preprotein translocase
IGS74_10175	COG3737	Protein of unknown function (DUF498/DUF598)
IGS74_10195	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IGS74_10210	COG0544	peptidyl-prolyl cis-trans isomerase activity
IGS74_10225	COG0740	serine-type endopeptidase activity
IGS74_10230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IGS74_10235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IGS74_10240	COG0776	regulation of translation
IGS74_10245	COG2814	Major facilitator Superfamily
IGS74_10255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IGS74_10295	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS74_10300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS74_10305	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS74_10315	COG0649	NAD binding
IGS74_10320	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IGS74_10325	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IGS74_10335	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IGS74_10340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IGS74_10350	COG0713	ATP synthesis coupled electron transport
IGS74_10365	COG1007	ATP synthesis coupled electron transport
IGS74_10380	COG0346	lactoylglutathione lyase activity
IGS74_10390	COG0442	prolyl-tRNA aminoacylation
IGS74_10400	COG1136	(ABC) transporter
IGS74_10415	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IGS74_10430	COG0784	Response regulator, receiver
IGS74_10435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IGS74_10455	COG0557	exoribonuclease II activity
IGS74_10460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IGS74_10460	COG1754	DNA topoisomerase type I activity
IGS74_10465	COG0758	DNA mediated transformation
IGS74_10470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IGS74_10475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IGS74_10480	COG0540	Belongs to the ATCase OTCase family
IGS74_10485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IGS74_10490	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IGS74_10495	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IGS74_10515	COG4765	Protein conserved in bacteria
IGS74_10525	COG0625	glutathione transferase activity
IGS74_10535	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IGS74_10540	COG1902	pentaerythritol trinitrate reductase activity
IGS74_10555	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IGS74_10560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IGS74_10565	COG0628	permease
IGS74_10575	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IGS74_10590	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS74_10595	COG1129	ABC transporter
IGS74_10605	COG2186	Transcriptional regulator
IGS74_10610	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
IGS74_10615	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IGS74_10625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IGS74_10645	COG0113	porphobilinogen synthase activity
IGS74_10665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IGS74_10670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IGS74_10675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IGS74_10675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IGS74_10690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IGS74_10710	COG0416	fatty acid biosynthetic process
IGS74_10715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IGS74_10720	COG0776	regulation of translation
IGS74_10835	COG1971	Probably functions as a manganese efflux pump
IGS74_10860	COG0601	transmembrane transport
IGS74_10865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS74_10875	COG4608	Belongs to the ABC transporter superfamily
IGS74_10890	COG1320	monovalent cation:proton antiporter activity
IGS74_10895	COG2212	antiporter activity
IGS74_10900	COG1863	multisubunit Na H antiporter MnhE subunit
IGS74_10905	COG0651	ATP synthesis coupled electron transport
IGS74_10910	COG1006	Multisubunit Na H antiporter MnhC subunit
IGS74_10915	COG2111	Na H antiporter
IGS74_10920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IGS74_10920	COG2111	Na H antiporter
IGS74_10925	COG1115	amino acid carrier protein
IGS74_10930	COG0003	Pfam Anion-transporting ATPase
IGS74_10940	COG1966	Carbon starvation protein
IGS74_10945	COG1238	metal cluster binding
IGS74_10950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IGS74_10955	COG0671	phosphoesterase, PA-phosphatase related
IGS74_10985	COG3842	ATPase activity
IGS74_10990	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGS74_10995	COG1177	transmembrane transport
IGS74_11000	COG0405	Gamma-glutamyltransferase
IGS74_11030	COG1595	DNA-templated transcription, initiation
IGS74_11045	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IGS74_11050	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IGS74_11065	COG0785	Cytochrome C biogenesis protein
IGS74_11070	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IGS74_11090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IGS74_11105	COG0187	DNA topoisomerase II activity
IGS74_11115	COG0174	glutamine synthetase
IGS74_11120	COG0347	Belongs to the P(II) protein family
IGS74_11125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IGS74_11125	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IGS74_11130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IGS74_11140	COG2095	MarC family integral membrane protein
IGS74_11145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IGS74_11150	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IGS74_11170	COG0343	queuine tRNA-ribosyltransferase activity
IGS74_11180	COG2382	esterase
IGS74_11180	COG3693	PFAM glycoside hydrolase, family 10
IGS74_11210	COG0655	NAD(P)H dehydrogenase (quinone) activity
IGS74_11215	COG1546	Belongs to the CinA family
IGS74_11215	COG1058	Belongs to the CinA family
IGS74_11220	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IGS74_11230	COG3284	Transcriptional regulator
IGS74_11235	COG2239	Acts as a magnesium transporter
IGS74_11250	COG4774	siderophore transport
IGS74_11260	COG0277	FAD linked oxidase domain protein
IGS74_11265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IGS74_11275	COG2814	Major facilitator Superfamily
IGS74_11285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS74_11295	COG1012	belongs to the aldehyde dehydrogenase family
IGS74_11300	COG1454	alcohol dehydrogenase
IGS74_11315	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IGS74_11325	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IGS74_11330	COG2205	protein histidine kinase activity
IGS74_11340	COG1620	l-lactate permease
IGS74_11345	COG1320	monovalent cation:proton antiporter activity
IGS74_11350	COG2212	antiporter activity
IGS74_11360	COG0651	ATP synthesis coupled electron transport
IGS74_11365	COG1006	Multisubunit Na H antiporter MnhC subunit
IGS74_11370	COG2111	Na H antiporter
IGS74_11375	COG2111	Na H antiporter
IGS74_11375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IGS74_11395	COG4589	Belongs to the CDS family
IGS74_11400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IGS74_11405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IGS74_11405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IGS74_11410	COG2198	Histidine kinase
IGS74_11410	COG0784	Response regulator, receiver
IGS74_11410	COG5002	protein histidine kinase activity
IGS74_11415	COG0745	RESPONSE REGULATOR receiver
IGS74_11420	COG3920	Histidine kinase
IGS74_11445	COG0438	transferase activity, transferring glycosyl groups
IGS74_11450	COG0697	spore germination
IGS74_11455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IGS74_11470	COG2610	gluconate transmembrane transporter activity
IGS74_11480	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_11485	COG1309	transcriptional regulator
IGS74_11500	COG3454	Phosphonate metabolism
IGS74_11505	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
IGS74_11510	COG3639	organic phosphonate transmembrane transporter activity
IGS74_11515	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IGS74_11520	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IGS74_11525	COG4778	phosphonate C-P lyase system protein PhnL
IGS74_11530	COG4107	phosphonate C-P lyase system protein PhnK
IGS74_11535	COG3627	carbon phosphorus lyase activity
IGS74_11540	COG3626	phosphonate metabolism
IGS74_11545	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
IGS74_11550	COG3624	Phosphonate C-P lyase system protein PhnG
IGS74_11560	COG0402	S-adenosylhomocysteine deaminase activity
IGS74_11565	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
IGS74_11595	COG3842	ATPase activity
IGS74_11605	COG1177	transmembrane transport
IGS74_11625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS74_11630	COG0251	oxidation-reduction process
IGS74_11640	COG5383	Protein conserved in bacteria
IGS74_11665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IGS74_11685	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IGS74_11690	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IGS74_11695	COG3639	organic phosphonate transmembrane transporter activity
IGS74_11700	COG2202	Pas domain
IGS74_11700	COG3920	Histidine kinase
IGS74_11725	COG4213	ABC transporter substrate-binding protein
IGS74_11730	COG4214	carbohydrate transport
IGS74_11745	COG2423	ornithine cyclodeaminase activity
IGS74_11750	COG3616	Alanine racemase, N-terminal domain
IGS74_11755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IGS74_11760	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IGS74_11765	COG1414	Transcriptional regulator
IGS74_11780	COG2351	hydroxyisourate hydrolase activity
IGS74_11790	COG3257	ureidoglycine aminohydrolase activity
IGS74_11795	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
IGS74_11805	COG2233	PERMEase
IGS74_11810	COG0402	S-adenosylhomocysteine deaminase activity
IGS74_11820	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS74_11835	COG2252	PERMEase
IGS74_11860	COG4154	Belongs to the RbsD FucU family
IGS74_11870	COG0321	lipoyl(octanoyl) transferase activity
IGS74_11870	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IGS74_11875	COG0084	hydrolase, TatD family'
IGS74_11890	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IGS74_11905	COG1278	Cold shock
IGS74_11960	COG0583	DNA-binding transcription factor activity
IGS74_12045	COG2860	membrane
IGS74_12050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IGS74_12065	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IGS74_12080	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IGS74_12085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IGS74_12090	COG2188	Transcriptional regulator
IGS74_12100	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IGS74_12110	COG1175	transmembrane transport
IGS74_12120	COG0673	inositol 2-dehydrogenase activity
IGS74_12135	COG2910	NAD(P)H-binding
IGS74_12160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS74_12170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS74_12180	COG2186	Transcriptional regulator
IGS74_12195	COG0297	glycogen (starch) synthase activity
IGS74_12200	COG0438	transferase activity, transferring glycosyl groups
IGS74_12205	COG1216	Glycosyl transferase, family 2
IGS74_12210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IGS74_12230	COG0523	cobalamin synthesis protein
IGS74_12235	COG1802	Transcriptional regulator
IGS74_12240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS74_12245	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IGS74_12255	COG0434	BtpA family
IGS74_12260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS74_12270	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS74_12280	COG1609	Transcriptional regulator
IGS74_12320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS74_12325	COG1802	Transcriptional regulator
IGS74_12340	COG1335	isochorismatase
IGS74_12345	COG3845	ABC transporter
IGS74_12355	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IGS74_12360	COG1079	Belongs to the binding-protein-dependent transport system permease family
IGS74_12375	COG2271	Major facilitator Superfamily
IGS74_12385	COG0165	Argininosuccinate lyase
IGS74_12390	COG2176	DNA-directed DNA polymerase activity
IGS74_12415	COG0625	glutathione transferase activity
IGS74_12425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IGS74_12435	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IGS74_12440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGS74_12440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IGS74_12455	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IGS74_12460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS74_12470	COG4172	Belongs to the ABC transporter superfamily
IGS74_12490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS74_12495	COG2391	methyltransferase activity
IGS74_12505	COG3077	Addiction module antitoxin, RelB DinJ family
IGS74_12515	COG0477	Major facilitator Superfamily
IGS74_12520	COG0583	DNA-binding transcription factor activity
IGS74_12525	COG4948	Mandelate Racemase Muconate Lactonizing
IGS74_12535	COG0473	3-isopropylmalate dehydrogenase activity
IGS74_12545	COG2376	Dihydroxyacetone kinase
IGS74_12550	COG1461	Dihydroxyacetone kinase
IGS74_12555	COG1461	Dihydroxyacetone kinase
IGS74_12560	COG2376	Dihydroxyacetone kinase
IGS74_12570	COG1879	ABC-type sugar transport system periplasmic component
IGS74_12575	COG1129	ABC transporter
IGS74_12580	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS74_12610	COG1129	ABC transporter
IGS74_12615	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS74_12625	COG1349	DNA-binding transcription factor activity
IGS74_12635	COG1349	DNA-binding transcription factor activity
IGS74_12640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IGS74_12665	COG0191	fructose-bisphosphate aldolase activity
IGS74_12675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IGS74_12695	COG1802	Transcriptional regulator
IGS74_12700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS74_12735	COG1175	transmembrane transport
IGS74_12750	COG2188	Transcriptional regulator
IGS74_12755	COG3842	ATPase activity
IGS74_12760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IGS74_12760	COG0475	glutathione-regulated potassium exporter activity
IGS74_12770	COG3845	ABC transporter
IGS74_12780	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IGS74_12785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IGS74_12790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS74_12800	COG1126	abc transporter atp-binding protein
IGS74_12805	COG0765	amino acid transport
IGS74_12810	COG0765	amino acid transport
IGS74_12820	COG0698	ribose 5-phosphate isomerase
IGS74_12845	COG1917	Cupin 2, conserved barrel domain protein
IGS74_12850	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IGS74_12860	COG1063	alcohol dehydrogenase
IGS74_12875	COG1473	amidohydrolase
IGS74_12880	COG0583	DNA-binding transcription factor activity
IGS74_12890	COG1012	belongs to the aldehyde dehydrogenase family
IGS74_12900	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IGS74_12905	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_12910	COG3956	TIGRFAM MazG family protein
IGS74_12915	COG1794	racemase activity, acting on amino acids and derivatives
IGS74_12920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IGS74_12930	COG0569	domain protein
IGS74_12935	COG2204	response regulator
IGS74_12940	COG5000	phosphorelay sensor kinase activity
IGS74_12945	COG2204	response regulator
IGS74_12950	COG3852	Histidine kinase
IGS74_12960	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IGS74_12960	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IGS74_12980	COG2867	negative regulation of translational initiation
IGS74_12985	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IGS74_12995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IGS74_13000	COG0508	dehydrogenase complex catalyzes the overall conversion of
IGS74_13005	COG0022	dehydrogenase e1 component
IGS74_13005	COG0508	dehydrogenase complex catalyzes the overall conversion of
IGS74_13010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IGS74_13020	COG0148	phosphopyruvate hydratase activity
IGS74_13045	COG0504	CTP synthase activity
IGS74_13055	COG0149	triose-phosphate isomerase activity
IGS74_13060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IGS74_13065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IGS74_13070	COG0134	indole-3-glycerol-phosphate synthase activity
IGS74_13075	COG0315	cyclic pyranopterin monophosphate synthase activity
IGS74_13100	COG0372	Belongs to the citrate synthase family
IGS74_13115	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IGS74_13125	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IGS74_13130	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IGS74_13135	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IGS74_13145	COG0750	zinc metalloprotease
IGS74_13155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IGS74_13160	COG0233	cytoplasmic translational termination
IGS74_13165	COG0528	UMP kinase activity
IGS74_13170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IGS74_13175	COG0052	Belongs to the universal ribosomal protein uS2 family
IGS74_13220	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IGS74_13230	COG1686	Belongs to the peptidase S11 family
IGS74_13270	COG2239	Acts as a magnesium transporter
IGS74_13280	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IGS74_13285	COG1024	Enoyl-CoA hydratase
IGS74_13290	COG2205	protein histidine kinase activity
IGS74_13290	COG0784	Response regulator, receiver
IGS74_13290	COG2198	Histidine kinase
IGS74_13310	COG0431	NADPH-dependent FMN reductase
IGS74_13320	COG2376	Dihydroxyacetone kinase
IGS74_13330	COG1129	ABC transporter
IGS74_13335	COG1879	ABC-type sugar transport system periplasmic component
IGS74_13350	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS74_13355	COG0434	BtpA family
IGS74_13360	COG1349	DNA-binding transcription factor activity
IGS74_13385	COG1959	2 iron, 2 sulfur cluster binding
IGS74_13390	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IGS74_13410	COG1183	phosphatidylcholine synthase activity
IGS74_13415	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IGS74_13430	COG4166	transmembrane transport
IGS74_13445	COG2151	metal-sulfur cluster biosynthetic enzyme
IGS74_13450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IGS74_13455	COG0719	Fe-S assembly protein
IGS74_13460	COG0396	ATPase activity
IGS74_13465	COG0719	Fe-S assembly protein
IGS74_13475	COG2945	thiolester hydrolase activity
IGS74_13480	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IGS74_13490	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IGS74_13500	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IGS74_13505	COG0860	N-Acetylmuramoyl-L-alanine amidase
IGS74_13510	COG1530	ribonuclease E activity
IGS74_13515	COG0436	Aminotransferase
IGS74_13530	COG0511	ligase activity, forming carbon-carbon bonds
IGS74_13535	COG0439	Biotin carboxylase
IGS74_13540	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IGS74_13555	COG0322	excinuclease ABC activity
IGS74_13560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IGS74_13570	COG0314	molybdopterin synthase activity
IGS74_13575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS74_13580	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IGS74_13585	COG0105	UTP biosynthetic process
IGS74_13595	COG0488	(ABC) transporter
IGS74_13600	COG1648	precorrin-2 dehydrogenase activity
IGS74_13600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IGS74_13610	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IGS74_13625	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IGS74_13630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IGS74_13635	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IGS74_13640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IGS74_13645	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IGS74_13650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IGS74_13655	COG0194	GDP metabolic process
IGS74_13660	COG1561	YicC-like family, N-terminal region
IGS74_13665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IGS74_13670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGS74_13685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IGS74_13690	COG0360	Binds together with S18 to 16S ribosomal RNA
IGS74_13695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IGS74_13705	COG0359	binds to the 23S rRNA
IGS74_13715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IGS74_13730	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IGS74_13735	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_13750	COG1183	phosphatidylcholine synthase activity
IGS74_13755	COG0688	phosphatidylethanolamine metabolic process
IGS74_13760	COG5265	(ABC) transporter
IGS74_13770	COG2211	Major facilitator Superfamily
IGS74_13780	COG2308	Evidence 4 Homologs of previously reported genes of
IGS74_13800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IGS74_13815	COG2814	Major facilitator Superfamily
IGS74_13820	COG0746	molybdenum cofactor guanylyltransferase activity
IGS74_13835	COG0765	amino acid transport
IGS74_13840	COG2084	Dehydrogenase
IGS74_13845	COG1522	sequence-specific DNA binding
IGS74_13855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IGS74_13870	COG0415	Belongs to the DNA photolyase family
IGS74_13875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IGS74_13880	COG2897	thiosulfate sulfurtransferase activity
IGS74_13890	COG0737	Belongs to the 5'-nucleotidase family
IGS74_13900	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IGS74_13905	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IGS74_13925	COG1126	abc transporter atp-binding protein
IGS74_13930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS74_13940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IGS74_13945	COG1522	sequence-specific DNA binding
IGS74_13980	COG3409	Peptidoglycan-binding domain 1 protein
IGS74_13980	COG3267	Type II secretory pathway component ExeA
IGS74_13995	COG1596	polysaccharide export
IGS74_14010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IGS74_14025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IGS74_14060	COG0280	phosphate acetyltransferase
IGS74_14060	COG0281	malic enzyme
IGS74_14065	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IGS74_14065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IGS74_14080	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IGS74_14100	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IGS74_14105	COG0546	phosphoglycolate phosphatase activity
IGS74_14145	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IGS74_14150	COG3181	Tripartite tricarboxylate transporter family receptor
IGS74_14170	COG1126	abc transporter atp-binding protein
IGS74_14175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS74_14180	COG0765	amino acid transport
IGS74_14190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IGS74_14225	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS74_14230	COG1172	Belongs to the binding-protein-dependent transport system permease family
IGS74_14235	COG1129	ABC transporter
IGS74_14240	COG1879	ABC-type sugar transport system periplasmic component
IGS74_14245	COG1609	Transcriptional regulator
IGS74_14255	COG0673	inositol 2-dehydrogenase activity
IGS74_14260	COG3842	ATPase activity
IGS74_14270	COG0395	ABC-type sugar transport system, permease component
IGS74_14275	COG1175	transmembrane transport
IGS74_14280	COG1653	transport
IGS74_14285	COG1609	Transcriptional regulator
IGS74_14310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGS74_14320	COG0277	FAD linked oxidase domain protein
IGS74_14330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IGS74_14355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGS74_14370	COG3383	formate dehydrogenase (NAD+) activity
IGS74_14385	COG0583	DNA-binding transcription factor activity
IGS74_14390	COG0400	carboxylic ester hydrolase activity
IGS74_14395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IGS74_14400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IGS74_14405	COG0778	Nitroreductase
IGS74_14425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IGS74_14430	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IGS74_14430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IGS74_14440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IGS74_14450	COG3214	Protein conserved in bacteria
IGS74_14455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IGS74_14460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IGS74_14470	COG0302	gtp cyclohydrolase
IGS74_14480	COG1752	Esterase of the alpha-beta hydrolase superfamily
IGS74_14485	COG2239	Acts as a magnesium transporter
IGS74_14510	COG0596	Alpha beta hydrolase
IGS74_14520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IGS74_14530	COG0628	permease
IGS74_14535	COG1126	abc transporter atp-binding protein
IGS74_14540	COG0765	amino acid transport
IGS74_14545	COG4597	amino acid ABC transporter
IGS74_14550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS74_14555	COG0626	cystathionine gamma-synthase activity
IGS74_14570	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IGS74_14575	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IGS74_14580	COG0010	Belongs to the arginase family
IGS74_14585	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IGS74_14590	COG1612	heme a metabolic process
IGS74_14620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS74_14625	COG1126	abc transporter atp-binding protein
IGS74_14630	COG0765	amino acid transport
IGS74_14635	COG0765	amino acid transport
IGS74_14640	COG2721	sulfolactate sulfo-lyase activity
IGS74_14650	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_14655	COG4604	ABC transporter, ATP-binding protein
IGS74_14660	COG4605	iron ion homeostasis
IGS74_14665	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IGS74_14670	COG4607	ABC-type enterochelin transport system periplasmic component
IGS74_14675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IGS74_14675	COG1648	precorrin-2 dehydrogenase activity
IGS74_14695	COG3938	Belongs to the proline racemase family
IGS74_14720	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
IGS74_14750	COG0321	lipoyl(octanoyl) transferase activity
IGS74_14755	COG1671	Belongs to the UPF0178 family
IGS74_14765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IGS74_14785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IGS74_14790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IGS74_14795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGS74_14810	COG0203	ribosomal protein L17
IGS74_14815	COG0202	RNA polymerase activity
IGS74_14820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IGS74_14825	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IGS74_14830	COG0563	adenylate kinase activity
IGS74_14835	COG0201	protein transport
IGS74_14840	COG0200	Binds to the 23S rRNA
IGS74_14845	COG1841	ribosomal large subunit assembly
IGS74_14850	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IGS74_14855	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IGS74_14870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IGS74_14875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IGS74_14880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IGS74_14885	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IGS74_14890	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IGS74_14900	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IGS74_14905	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IGS74_14915	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IGS74_14920	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IGS74_14930	COG0088	Forms part of the polypeptide exit tunnel
IGS74_14935	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IGS74_14945	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IGS74_14950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IGS74_14955	COG0049	tRNA binding
IGS74_14960	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IGS74_14965	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IGS74_14970	COG0085	RNA polymerase activity
IGS74_14975	COG0222	ribosome binding
IGS74_14980	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IGS74_14985	COG0081	regulation of translation
IGS74_14990	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IGS74_15010	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IGS74_15025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IGS74_15035	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
IGS74_15040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IGS74_15045	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IGS74_15050	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IGS74_15080	COG2323	membrane
IGS74_15125	COG5001	Diguanylate cyclase
IGS74_15140	COG0513	Belongs to the DEAD box helicase family
IGS74_15160	COG2194	sulfuric ester hydrolase activity
IGS74_15170	COG4953	penicillin-binding protein 1C
IGS74_15190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IGS74_15205	COG0436	Aminotransferase
IGS74_15215	COG3243	poly(R)-hydroxyalkanoic acid synthase
IGS74_15220	COG0024	Methionine aminopeptidase
IGS74_15225	COG2003	Belongs to the UPF0758 family
IGS74_15230	COG5425	PFAM Usg family protein
IGS74_15240	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IGS74_15250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IGS74_15265	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IGS74_15275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IGS74_15285	COG3836	Belongs to the HpcH HpaI aldolase family
IGS74_15295	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IGS74_15300	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IGS74_15305	COG0047	phosphoribosylformylglycinamidine synthase activity
IGS74_15320	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IGS74_15330	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IGS74_15335	COG0483	inositol monophosphate 1-phosphatase activity
IGS74_15340	COG0037	tRNA processing
IGS74_15345	COG3300	MHYT domain
IGS74_15345	COG5001	Diguanylate cyclase
IGS74_15350	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IGS74_15365	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IGS74_15375	COG0538	isocitrate dehydrogenase activity
IGS74_15400	COG1959	2 iron, 2 sulfur cluster binding
IGS74_15435	COG1070	Carbohydrate kinase
IGS74_15445	COG1268	BioY protein
IGS74_15450	COG1122	ATPase activity
IGS74_15480	COG0215	cysteine-tRNA ligase activity
IGS74_15520	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IGS74_15530	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IGS74_15540	COG1381	Involved in DNA repair and RecF pathway recombination
IGS74_15545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IGS74_15555	COG0681	Belongs to the peptidase S26 family
IGS74_15570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IGS74_15580	COG1758	RNA polymerase activity
IGS74_15590	COG1573	uracil-dna glycosylase
IGS74_15595	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IGS74_15600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IGS74_15605	COG1196	nuclear chromosome segregation
IGS74_15605	COG0741	lytic transglycosylase activity
IGS74_15605	COG0739	heme binding
IGS74_15640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IGS74_15655	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IGS74_15665	COG1573	uracil-dna glycosylase
IGS74_15670	COG0477	Major facilitator Superfamily
IGS74_15680	COG0308	aminopeptidase N
IGS74_15685	COG2202	Pas domain
IGS74_15685	COG2205	protein histidine kinase activity
IGS74_15700	COG0745	RESPONSE REGULATOR receiver
IGS74_15705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGS74_15710	COG3088	subunit of a heme lyase
IGS74_15715	COG1138	Cytochrome C-type biogenesis protein
IGS74_15720	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IGS74_15725	COG4235	cytochrome complex assembly
IGS74_15855	COG2983	Belongs to the UPF0260 family
IGS74_15860	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
IGS74_15900	COG2166	iron-sulfur cluster assembly
IGS74_15930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IGS74_15935	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IGS74_15940	COG2080	2 iron, 2 sulfur cluster binding
IGS74_15945	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
IGS74_15950	COG0534	Mate efflux family protein
IGS74_15955	COG0246	Mannitol dehydrogenase
IGS74_15960	COG1063	alcohol dehydrogenase
IGS74_15985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS74_15990	COG0601	transmembrane transport
IGS74_15995	COG0747	negative chemotaxis
IGS74_16000	COG0747	negative chemotaxis
IGS74_16005	COG0154	amidase activity
IGS74_16030	COG0318	PFAM AMP-dependent synthetase and ligase
IGS74_16035	COG1012	belongs to the aldehyde dehydrogenase family
IGS74_16040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IGS74_16045	COG0183	Belongs to the thiolase family
IGS74_16050	COG1024	Enoyl-CoA hydratase
IGS74_16050	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS74_16085	COG0459	protein refolding
IGS74_16090	COG3842	ATPase activity
IGS74_16100	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGS74_16105	COG1177	transmembrane transport
IGS74_16110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IGS74_16165	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IGS74_16200	COG3842	ATPase activity
IGS74_16205	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_16240	COG3842	ATPase activity
IGS74_16255	COG1653	transport
IGS74_16270	COG1609	Transcriptional regulator
IGS74_16275	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
IGS74_16305	COG0583	DNA-binding transcription factor activity
IGS74_16315	COG2814	Major facilitator Superfamily
IGS74_16325	COG1960	acyl-CoA dehydrogenase activity
IGS74_16345	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_16350	COG3842	ATPase activity
IGS74_16360	COG1178	ABC-type Fe3 transport system permease component
IGS74_16365	COG2186	Transcriptional regulator
IGS74_16380	COG0473	3-isopropylmalate dehydrogenase activity
IGS74_16390	COG0596	Alpha beta hydrolase
IGS74_16435	COG0482	sulfurtransferase activity
IGS74_16445	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IGS74_16460	COG0564	pseudouridine synthase activity
IGS74_16465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IGS74_16500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IGS74_16505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IGS74_16510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IGS74_16520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IGS74_16525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IGS74_16530	COG0037	tRNA processing
IGS74_16540	COG2885	chlorophyll binding
IGS74_16545	COG0823	Involved in the tonB-independent uptake of proteins
IGS74_16565	COG0824	Thioesterase
IGS74_16570	COG2255	four-way junction helicase activity
IGS74_16575	COG0632	four-way junction helicase activity
IGS74_16580	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IGS74_16590	COG0217	transcriptional regulatory protein
IGS74_16595	COG1692	metallophosphoesterase
IGS74_16635	COG0126	phosphoglycerate kinase activity
IGS74_16660	COG1201	RNA secondary structure unwinding
IGS74_16675	COG0730	response to heat
IGS74_16685	COG1960	acyl-CoA dehydrogenase activity
IGS74_16690	COG0183	Belongs to the thiolase family
IGS74_16695	COG1024	Enoyl-CoA hydratase
IGS74_16695	COG1250	3-hydroxyacyl-CoA dehydrogenase
IGS74_16715	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IGS74_16730	COG1376	ErfK ybiS ycfS ynhG family protein
IGS74_16730	COG1388	LysM domain
IGS74_16755	COG1393	Belongs to the ArsC family
IGS74_16765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IGS74_16770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IGS74_16780	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IGS74_16785	COG1063	alcohol dehydrogenase
IGS74_16795	COG0784	Response regulator, receiver
IGS74_16840	COG1280	lysine exporter protein (LysE YggA)
IGS74_16845	COG3979	chitinase
IGS74_16850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IGS74_16860	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IGS74_16865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IGS74_16875	COG0440	acetolactate synthase activity
IGS74_16880	COG0028	Belongs to the TPP enzyme family
IGS74_16885	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IGS74_16900	COG0330	HflC and HflK could
IGS74_16905	COG0330	HflC and HflK could
IGS74_16910	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IGS74_16935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IGS74_16950	COG2610	gluconate transmembrane transporter activity
IGS74_16955	COG4413	Urea transporter
IGS74_16960	COG0804	urea catabolic process
IGS74_16965	COG0832	Belongs to the urease beta subunit family
IGS74_16970	COG0831	urea catabolic process
IGS74_16975	COG0829	nickel cation binding
IGS74_16980	COG0830	nickel cation binding
IGS74_16985	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IGS74_16990	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IGS74_17010	COG3842	ATPase activity
IGS74_17015	COG3842	ATPase activity
IGS74_17025	COG0395	ABC-type sugar transport system, permease component
IGS74_17040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IGS74_17045	COG0628	permease
IGS74_17055	COG0444	Belongs to the ABC transporter superfamily
IGS74_17065	COG0747	negative chemotaxis
IGS74_17075	COG1960	acyl-CoA dehydrogenase activity
IGS74_17085	COG1403	HNH endonuclease
IGS74_17090	COG0745	RESPONSE REGULATOR receiver
IGS74_17095	COG0704	Plays a role in the regulation of phosphate uptake
IGS74_17100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IGS74_17110	COG0573	inorganic phosphate transmembrane transporter activity
IGS74_17120	COG5002	protein histidine kinase activity
IGS74_17130	COG3387	PFAM Glycoside hydrolase 15-related
IGS74_17145	COG0604	alcohol dehydrogenase
IGS74_17145	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_17145	COG3321	synthase
IGS74_17155	COG0254	rRNA binding
IGS74_17160	COG1132	(ABC) transporter
IGS74_17175	COG1174	glycine betaine transport
IGS74_17180	COG1125	glycine betaine transport
IGS74_17185	COG1174	glycine betaine transport
IGS74_17190	COG1732	Glycine betaine
IGS74_17205	COG0747	negative chemotaxis
IGS74_17210	COG0601	transmembrane transport
IGS74_17225	COG1124	(ABC) transporter
IGS74_17230	COG2197	response regulator
IGS74_17265	COG0714	Associated with various cellular activities
IGS74_17305	COG1473	amidohydrolase
IGS74_17315	COG0156	8-amino-7-oxononanoate synthase activity
IGS74_17320	COG1063	alcohol dehydrogenase
IGS74_17330	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IGS74_17345	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_17350	COG3842	ATPase activity
IGS74_17355	COG1840	ABC-type Fe3 transport system, periplasmic component
IGS74_17385	COG2259	Doxx family
IGS74_17390	COG0583	DNA-binding transcription factor activity
IGS74_17395	COG2514	catechol 2,3-dioxygenase activity
IGS74_17405	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IGS74_17410	COG4208	sulfate ABC transporter
IGS74_17450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IGS74_17455	COG1396	sequence-specific DNA binding
IGS74_17455	COG1917	Cupin 2, conserved barrel domain protein
IGS74_17465	COG3842	ATPase activity
IGS74_17470	COG1176	ABC-type spermidine putrescine transport system, permease component I
IGS74_17475	COG1177	transmembrane transport
IGS74_17480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IGS74_17485	COG0784	Response regulator, receiver
IGS74_17485	COG4191	Histidine kinase
IGS74_17490	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IGS74_17500	COG4214	carbohydrate transport
IGS74_17505	COG1129	ABC transporter
IGS74_17510	COG4213	ABC transporter substrate-binding protein
IGS74_17515	COG0800	Aldolase
IGS74_17520	COG3734	2-keto-3-deoxy-galactonokinase
IGS74_17525	COG3386	PFAM SMP-30 Gluconolaconase
IGS74_17530	COG0129	dihydroxy-acid dehydratase activity
IGS74_17545	COG2186	Transcriptional regulator
IGS74_17580	COG0617	tRNA 3'-terminal CCA addition
IGS74_17595	COG0714	Associated with various cellular activities
IGS74_17625	COG0435	Glutathione S-transferase
IGS74_17630	COG0494	nUDIX hydrolase
IGS74_17640	COG3135	benzoate transporter
IGS74_17650	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IGS74_17660	COG0512	Glutamine amidotransferase of anthranilate synthase
IGS74_17660	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IGS74_17665	COG2759	Belongs to the formate--tetrahydrofolate ligase family
IGS74_17670	COG4176	ABC-type proline glycine betaine transport system permease component
IGS74_17675	COG4175	Glycine betaine
IGS74_17685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IGS74_17695	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IGS74_17705	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IGS74_17710	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IGS74_17720	COG0295	cytidine deaminase activity
IGS74_17730	COG2900	Belongs to the SlyX family
IGS74_17735	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IGS74_17770	COG2948	multi-organism process
IGS74_17785	COG3846	protein secretion by the type IV secretion system
IGS74_17800	COG3451	type IV secretory pathway VirB4
IGS74_17815	COG4962	Type ii secretion system protein e
IGS74_17830	COG0583	DNA-binding transcription factor activity
IGS74_17835	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IGS74_17845	COG0590	tRNA wobble adenosine to inosine editing
IGS74_17855	COG2076	Multidrug Resistance protein
IGS74_17860	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IGS74_17865	COG0583	DNA-binding transcription factor activity
IGS74_17870	COG0477	Major facilitator Superfamily
IGS74_17885	COG0583	DNA-binding transcription factor activity
IGS74_17900	COG0741	lytic transglycosylase activity
IGS74_17945	COG5489	Protein of unknown function (DUF736)
IGS74_17955	COG1487	ribonuclease activity
IGS74_17960	COG4691	Plasmid stability protein
IGS74_18110	COG0582	viral genome integration into host DNA
IGS74_18115	COG3177	Filamentation induced by cAMP protein fic
IGS74_18125	COG0210	DNA helicase
IGS74_18135	COG3093	addiction module antidote protein HigA
IGS74_18145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS74_18150	COG1126	abc transporter atp-binding protein
IGS74_18165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IGS74_18170	COG1902	pentaerythritol trinitrate reductase activity
IGS74_18170	COG0446	pyridine nucleotide-disulphide oxidoreductase
IGS74_18185	COG0583	DNA-binding transcription factor activity
IGS74_18190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IGS74_18200	COG1309	transcriptional regulator
IGS74_18210	COG1742	UPF0060 membrane protein
IGS74_18220	COG3422	double-strand break repair
IGS74_18225	COG2186	Transcriptional regulator
IGS74_18270	COG0739	heme binding
IGS74_18275	COG0667	Aldo Keto reductase
IGS74_18285	COG1376	ErfK ybiS ycfS ynhG family protein
IGS74_18295	COG0656	L-ascorbic acid biosynthetic process
IGS74_18305	COG0542	response to heat
IGS74_18315	COG2890	protein-(glutamine-N5) methyltransferase activity
IGS74_18320	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IGS74_18325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IGS74_18330	COG0527	aspartate kinase activity
IGS74_18335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IGS74_18345	COG4581	dead DEAH box helicase
IGS74_18355	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IGS74_18375	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
IGS74_18420	COG1253	flavin adenine dinucleotide binding
IGS74_18425	COG1253	flavin adenine dinucleotide binding
IGS74_18435	COG2066	Belongs to the glutaminase family
IGS74_18445	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IGS74_18450	COG1733	regulation of RNA biosynthetic process
IGS74_18470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IGS74_18475	COG3706	GGDEF domain
IGS74_18495	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
IGS74_18505	COG0559	Belongs to the binding-protein-dependent transport system permease family
IGS74_18535	COG1346	cytolysis
IGS74_18560	COG0183	Belongs to the thiolase family
IGS74_18565	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
IGS74_18570	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IGS74_18575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IGS74_18580	COG0142	geranyltranstransferase activity
IGS74_18605	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IGS74_18615	COG1640	4-alpha-glucanotransferase
IGS74_18620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IGS74_18650	COG0443	Heat shock 70 kDa protein
IGS74_18665	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_18675	COG0483	inositol monophosphate 1-phosphatase activity
IGS74_18690	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
IGS74_18695	COG2894	cell division
IGS74_18700	COG0850	regulation of cytokinetic process
IGS74_18715	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IGS74_18720	COG0363	glucosamine-6-phosphate deaminase activity
IGS74_18725	COG0129	dihydroxy-acid dehydratase activity
IGS74_18740	COG0583	DNA-binding transcription factor activity
IGS74_18760	COG3842	ATPase activity
IGS74_18765	COG0402	S-adenosylhomocysteine deaminase activity
IGS74_18780	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IGS74_18790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IGS74_18795	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IGS74_18805	COG0594	ribonuclease P activity
IGS74_18810	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IGS74_18815	COG3852	Histidine kinase
IGS74_18935	COG1733	regulation of RNA biosynthetic process
IGS74_18940	COG0702	epimerase
IGS74_18990	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_19005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IGS74_19010	COG1129	ABC transporter
IGS74_19010	COG0842	Transport permease protein
IGS74_19015	COG0842	Transport permease protein
IGS74_19030	COG1733	regulation of RNA biosynthetic process
IGS74_19085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IGS74_19100	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_19105	COG0803	Belongs to the bacterial solute-binding protein 9 family
IGS74_19110	COG3443	Belongs to the bacterial solute-binding protein 9 family
IGS74_19115	COG0287	Prephenate dehydrogenase
IGS74_19120	COG0673	inositol 2-dehydrogenase activity
IGS74_19130	COG2186	Transcriptional regulator
IGS74_19150	COG2186	Transcriptional regulator
IGS74_19155	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IGS74_19180	COG1116	anion transmembrane transporter activity
IGS74_19185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IGS74_19190	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS74_19195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IGS74_19205	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_19215	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_19220	COG0028	Belongs to the TPP enzyme family
IGS74_19240	COG2202	Pas domain
IGS74_19240	COG3920	Histidine kinase
IGS74_19245	COG4191	Histidine kinase
IGS74_19245	COG0784	Response regulator, receiver
IGS74_19265	COG0489	protein tyrosine kinase activity
IGS74_19265	COG3206	protein involved in exopolysaccharide biosynthesis
IGS74_19270	COG1215	transferase activity, transferring glycosyl groups
IGS74_19275	COG1215	transferase activity, transferring glycosyl groups
IGS74_19280	COG1215	transferase activity, transferring glycosyl groups
IGS74_19285	COG0438	transferase activity, transferring glycosyl groups
IGS74_19290	COG2273	Hydrolase Family 16
IGS74_19300	COG0463	Glycosyl transferase, family 2
IGS74_19305	COG1215	transferase activity, transferring glycosyl groups
IGS74_19315	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IGS74_19320	COG1596	polysaccharide export
IGS74_19325	COG3307	-O-antigen
IGS74_19330	COG0247	lactate metabolic process
IGS74_19335	COG1139	Iron-sulfur cluster binding protein
IGS74_19350	COG0512	Glutamine amidotransferase of anthranilate synthase
IGS74_19350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IGS74_19355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IGS74_19370	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
IGS74_19380	COG2943	transferase activity, transferring hexosyl groups
IGS74_19395	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IGS74_19400	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IGS74_19405	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IGS74_19415	COG1797	cobyrinic acid a,c-diamide synthase activity
IGS74_19425	COG2875	Belongs to the precorrin methyltransferase family
IGS74_19455	COG1492	cobalamin metabolic process
IGS74_19465	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_19500	COG1714	RDD family
IGS74_19505	COG1714	RDD family
IGS74_19510	COG1120	ATPase activity
IGS74_19515	COG1252	NADH dehydrogenase
IGS74_19525	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_19530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IGS74_19540	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IGS74_19545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IGS74_19550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IGS74_19555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IGS74_19560	COG0792	nuclease activity
IGS74_19565	COG0189	ligase activity
IGS74_19580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IGS74_19595	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IGS74_19605	COG0588	phosphoglycerate mutase activity
IGS74_19615	COG1132	(ABC) transporter
IGS74_19620	COG0837	glucose binding
IGS74_19625	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
IGS74_19640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IGS74_19645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IGS74_19650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IGS74_19655	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IGS74_19670	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IGS74_19675	COG0424	maF-like protein
IGS74_19680	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IGS74_19685	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IGS74_19715	COG1131	(ABC) transporter
IGS74_19720	COG0842	Transport permease protein
IGS74_19725	COG4770	biotin carboxylase activity
IGS74_19730	COG1999	signal sequence binding
IGS74_19735	COG4166	transmembrane transport
IGS74_19740	COG0601	transmembrane transport
IGS74_19745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IGS74_19750	COG4608	Belongs to the ABC transporter superfamily
IGS74_19760	COG0154	amidase activity
IGS74_19765	COG0444	Belongs to the ABC transporter superfamily
IGS74_19780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IGS74_19805	COG2226	methyltransferase
IGS74_19810	COG0756	dUTP diphosphatase activity
IGS74_19825	COG2226	methyltransferase
IGS74_19830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IGS74_19835	COG0268	Binds directly to 16S ribosomal RNA
IGS74_19840	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IGS74_19845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IGS74_19850	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IGS74_19860	COG1271	oxidase subunit
IGS74_19865	COG1294	oxidase, subunit
IGS74_19875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IGS74_19900	COG1609	Transcriptional regulator
IGS74_19905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IGS74_19910	COG1028	Short-chain dehydrogenase reductase Sdr
IGS74_19915	COG3842	ATPase activity
IGS74_19925	COG1175	transmembrane transport
IGS74_19930	COG0395	ABC-type sugar transport system, permease component
IGS74_19935	COG1522	sequence-specific DNA binding
IGS74_19940	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IGS74_19945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IGS74_19950	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IGS74_19955	COG2205	protein histidine kinase activity
IGS74_19960	COG3178	'Phosphotransferase
IGS74_19975	COG1074	ATP-dependent DNA helicase activity
IGS74_19985	COG4993	Dehydrogenase
IGS74_19995	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction