locus-tag	class	description
Sa4125_00030	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Sa4125_00070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Sa4125_00080	COG0840	transmembrane signaling receptor activity
Sa4125_00090	COG0840	transmembrane signaling receptor activity
Sa4125_00100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Sa4125_00110	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Sa4125_00140	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Sa4125_00150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Sa4125_00160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Sa4125_00170	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Sa4125_00180	COG0792	nuclease activity
Sa4125_00190	COG1487	ribonuclease activity
Sa4125_00210	COG0189	ligase activity
Sa4125_00220	COG0606	chelatase, subunit chli
Sa4125_00410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Sa4125_00420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Sa4125_00440	COG5001	Diguanylate cyclase
Sa4125_00440	COG2203	Gaf domain
Sa4125_00440	COG3706	GGDEF domain
Sa4125_00440	COG4251	negative regulation of phosphorylation
Sa4125_00470	COG1595	DNA-templated transcription, initiation
Sa4125_00500	COG1376	ErfK ybiS ycfS ynhG family protein
Sa4125_00520	COG1309	transcriptional regulator
Sa4125_00530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Sa4125_00540	COG0785	Cytochrome C biogenesis protein
Sa4125_00560	COG0606	chelatase, subunit chli
Sa4125_00570	COG2133	pyrroloquinoline quinone binding
Sa4125_00580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_00600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Sa4125_00640	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Sa4125_00650	COG1132	(ABC) transporter
Sa4125_00660	COG0837	glucose binding
Sa4125_00670	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
Sa4125_00680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sa4125_00680	COG0072	phenylalanine-tRNA ligase activity
Sa4125_00710	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Sa4125_00730	COG0785	Cytochrome C biogenesis protein
Sa4125_00750	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Sa4125_00760	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Sa4125_00810	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Sa4125_00820	COG0424	maF-like protein
Sa4125_00830	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Sa4125_00840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Sa4125_00870	COG1595	DNA-templated transcription, initiation
Sa4125_00880	COG1012	belongs to the aldehyde dehydrogenase family
Sa4125_00920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa4125_00960	COG1132	(ABC) transporter
Sa4125_00980	COG1234	tRNA 3'-trailer cleavage
Sa4125_01010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_01020	COG0601	transmembrane transport
Sa4125_01030	COG0747	negative chemotaxis
Sa4125_01050	COG4172	Belongs to the ABC transporter superfamily
Sa4125_01090	COG0438	transferase activity, transferring glycosyl groups
Sa4125_01100	COG0438	transferase activity, transferring glycosyl groups
Sa4125_01120	COG0840	transmembrane signaling receptor activity
Sa4125_01130	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_01150	COG1252	NADH dehydrogenase
Sa4125_01160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Sa4125_01170	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Sa4125_01180	COG2080	2 iron, 2 sulfur cluster binding
Sa4125_01250	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_01260	COG1492	cobalamin metabolic process
Sa4125_01350	COG2875	Belongs to the precorrin methyltransferase family
Sa4125_01370	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Sa4125_01380	COG1797	cobyrinic acid a,c-diamide synthase activity
Sa4125_01400	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Sa4125_01410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Sa4125_01430	COG5001	Diguanylate cyclase
Sa4125_01470	COG2943	transferase activity, transferring hexosyl groups
Sa4125_01490	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Sa4125_01520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Sa4125_01530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Sa4125_01540	COG0512	Glutamine amidotransferase of anthranilate synthase
Sa4125_01550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Sa4125_01590	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Sa4125_01600	COG4154	Belongs to the RbsD FucU family
Sa4125_01610	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Sa4125_01640	COG1063	alcohol dehydrogenase
Sa4125_01650	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_01660	COG3265	gluconokinase activity
Sa4125_01720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa4125_01730	COG1744	ABC transporter substrate-binding protein PnrA-like
Sa4125_01740	COG2900	Belongs to the SlyX family
Sa4125_01750	COG3845	ABC transporter
Sa4125_01770	COG4603	Belongs to the binding-protein-dependent transport system permease family
Sa4125_01780	COG1079	Belongs to the binding-protein-dependent transport system permease family
Sa4125_01810	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Sa4125_01820	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Sa4125_01840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Sa4125_01850	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Sa4125_01920	COG4964	Belongs to the GSP D family
Sa4125_01990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Sa4125_02010	COG0791	NLP P60 protein
Sa4125_02020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Sa4125_02030	COG1051	belongs to the nudix hydrolase family
Sa4125_02040	COG4172	Belongs to the ABC transporter superfamily
Sa4125_02050	COG1230	cation diffusion facilitator family transporter
Sa4125_02080	COG4239	(ABC) transporter, permease
Sa4125_02090	COG4174	ABC transporter (Permease)
Sa4125_02100	COG4166	transmembrane transport
Sa4125_02110	COG4166	transmembrane transport
Sa4125_02120	COG3474	cytochrome
Sa4125_02130	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Sa4125_02140	COG0077	Prephenate dehydratase
Sa4125_02140	COG1605	Chorismate mutase
Sa4125_02150	COG2816	NAD+ diphosphatase activity
Sa4125_02170	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Sa4125_02190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Sa4125_02210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Sa4125_02230	COG0242	peptide deformylase activity
Sa4125_02240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Sa4125_02250	COG0101	tRNA pseudouridine synthase activity
Sa4125_02260	COG2814	Major facilitator Superfamily
Sa4125_02290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Sa4125_02310	COG2171	N-acyltransferase activity
Sa4125_02350	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Sa4125_02370	COG3214	Protein conserved in bacteria
Sa4125_02410	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Sa4125_02420	COG0745	RESPONSE REGULATOR receiver
Sa4125_02430	COG2201	protein-glutamate methylesterase activity
Sa4125_02440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Sa4125_02450	COG0835	chemotaxis
Sa4125_02460	COG2198	Histidine kinase
Sa4125_02460	COG0643	Histidine kinase
Sa4125_02470	COG0745	RESPONSE REGULATOR receiver
Sa4125_02490	COG0840	transmembrane signaling receptor activity
Sa4125_02500	COG0514	ATP-dependent DNA helicase (RecQ)
Sa4125_02510	COG4774	siderophore transport
Sa4125_02520	COG1132	(ABC) transporter
Sa4125_02570	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Sa4125_02610	COG0596	Alpha beta hydrolase
Sa4125_02630	COG1126	abc transporter atp-binding protein
Sa4125_02680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Sa4125_02700	COG3335	DDE superfamily endonuclease
Sa4125_02710	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Sa4125_02720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Sa4125_02730	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Sa4125_02740	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Sa4125_02750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Sa4125_02780	COG0697	spore germination
Sa4125_02830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_02840	COG1126	abc transporter atp-binding protein
Sa4125_02870	COG3852	Histidine kinase
Sa4125_02880	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Sa4125_02890	COG0594	ribonuclease P activity
Sa4125_02920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Sa4125_02970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Sa4125_02980	COG5328	Belongs to the UPF0262 family
Sa4125_02990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Sa4125_03080	COG3206	protein involved in exopolysaccharide biosynthesis
Sa4125_03080	COG0489	protein tyrosine kinase activity
Sa4125_03090	COG2205	protein histidine kinase activity
Sa4125_03120	COG1570	exodeoxyribonuclease VII activity
Sa4125_03130	COG0583	DNA-binding transcription factor activity
Sa4125_03150	COG1253	flavin adenine dinucleotide binding
Sa4125_03190	COG2818	Glycosylase
Sa4125_03220	COG1388	LysM domain
Sa4125_03220	COG1376	ErfK ybiS ycfS ynhG family protein
Sa4125_03230	COG1388	LysM domain
Sa4125_03230	COG1376	ErfK ybiS ycfS ynhG family protein
Sa4125_03240	COG0174	glutamine synthetase
Sa4125_03260	COG2066	Belongs to the glutaminase family
Sa4125_03270	COG0247	lactate metabolic process
Sa4125_03300	COG0277	FAD linked oxidase domain protein
Sa4125_03320	COG0277	FAD linked oxidase domain protein
Sa4125_03330	COG0247	lactate metabolic process
Sa4125_03340	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Sa4125_03360	COG1139	Iron-sulfur cluster binding protein
Sa4125_03370	COG1556	Lactate utilization protein
Sa4125_03380	COG1280	lysine exporter protein (LysE YggA)
Sa4125_03400	COG0124	histidyl-tRNA synthetase
Sa4125_03410	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Sa4125_03420	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Sa4125_03430	COG4251	negative regulation of phosphorylation
Sa4125_03430	COG3706	GGDEF domain
Sa4125_03430	COG5001	Diguanylate cyclase
Sa4125_03430	COG2203	Gaf domain
Sa4125_03500	COG0730	response to heat
Sa4125_03520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Sa4125_03560	COG0196	riboflavin kinase activity
Sa4125_03570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Sa4125_03590	COG0590	tRNA wobble adenosine to inosine editing
Sa4125_03600	COG1187	pseudouridine synthase activity
Sa4125_03610	COG0742	ribosomal rna small subunit methyltransferase
Sa4125_03620	COG0612	Peptidase, M16
Sa4125_03630	COG0612	Peptidase, M16
Sa4125_03640	COG1752	Esterase of the alpha-beta hydrolase superfamily
Sa4125_03660	COG0475	glutathione-regulated potassium exporter activity
Sa4125_03660	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Sa4125_03670	COG0312	modulator of DNA gyrase
Sa4125_03710	COG1519	Transferase
Sa4125_03760	COG0033	Phosphoglucomutase
Sa4125_03770	COG0297	glycogen (starch) synthase activity
Sa4125_03780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Sa4125_03790	COG0058	SHG alpha-glucan phosphorylase activity
Sa4125_03800	COG0166	Belongs to the GPI family
Sa4125_03830	COG1012	belongs to the aldehyde dehydrogenase family
Sa4125_03850	COG0729	surface antigen
Sa4125_03940	COG1294	oxidase, subunit
Sa4125_03950	COG1271	oxidase subunit
Sa4125_04040	COG1304	FMN binding
Sa4125_04050	COG0583	DNA-binding transcription factor activity
Sa4125_04060	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Sa4125_04090	COG0126	phosphoglycerate kinase activity
Sa4125_04120	COG4451	ribulose bisphosphate carboxylase, small
Sa4125_04160	COG0778	Nitroreductase
Sa4125_04180	COG3293	Transposase
Sa4125_04190	COG1960	acyl-CoA dehydrogenase activity
Sa4125_04220	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sa4125_04220	COG1902	pentaerythritol trinitrate reductase activity
Sa4125_04240	COG4303	Ethanolamine ammonia lyase large subunit
Sa4125_04250	COG4302	ethanolamine ammonia-lyase activity
Sa4125_04260	COG0531	amino acid
Sa4125_04280	COG0861	Integral membrane protein TerC family
Sa4125_04320	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Sa4125_04330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Sa4125_04340	COG1121	(ABC) transporter
Sa4125_04350	COG0803	Belongs to the bacterial solute-binding protein 9 family
Sa4125_04370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_04380	COG1802	Transcriptional regulator
Sa4125_04390	COG1904	glucuronate isomerase
Sa4125_04400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Sa4125_04430	COG0246	Mannitol dehydrogenase
Sa4125_04460	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_04480	COG1054	Belongs to the UPF0176 family
Sa4125_04500	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Sa4125_04560	COG2226	methyltransferase
Sa4125_04610	COG2963	transposase activity
Sa4125_04620	COG3436	PFAM IS66 Orf2 family protein
Sa4125_04630	COG2433	Pfam Transposase IS66
Sa4125_04690	COG3328	transposase activity
Sa4125_04760	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Sa4125_04810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sa4125_04850	COG0438	transferase activity, transferring glycosyl groups
Sa4125_04870	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Sa4125_04910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sa4125_04920	COG0463	Glycosyl transferase, family 2
Sa4125_04990	COG0438	transferase activity, transferring glycosyl groups
Sa4125_05050	COG3206	protein involved in exopolysaccharide biosynthesis
Sa4125_05050	COG0489	protein tyrosine kinase activity
Sa4125_05100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Sa4125_05120	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Sa4125_05130	COG2197	response regulator
Sa4125_05200	COG3328	transposase activity
Sa4125_05270	COG0583	DNA-binding transcription factor activity
Sa4125_05280	COG2814	Major facilitator Superfamily
Sa4125_05300	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_05360	COG3246	L-lysine catabolic process to acetate
Sa4125_05370	COG1250	3-hydroxyacyl-CoA dehydrogenase
Sa4125_05410	COG1802	Transcriptional regulator
Sa4125_05420	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_05500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Sa4125_05510	COG1802	Transcriptional regulator
Sa4125_05530	COG0640	Transcriptional regulator
Sa4125_05550	COG5001	Diguanylate cyclase
Sa4125_05550	COG3300	MHYT domain
Sa4125_05560	COG3290	protein histidine kinase activity
Sa4125_05630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Sa4125_05640	COG2010	Cytochrome c
Sa4125_05640	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Sa4125_05690	COG0477	Major facilitator Superfamily
Sa4125_05700	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Sa4125_05740	COG0753	catalase activity
Sa4125_05770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Sa4125_05770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Sa4125_05780	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Sa4125_05800	COG0519	Catalyzes the synthesis of GMP from XMP
Sa4125_05800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Sa4125_05820	COG3788	relative of glutathione S-transferase, MAPEG superfamily
Sa4125_05850	COG1160	GTP binding
Sa4125_05880	COG0356	it plays a direct role in the translocation of protons across the membrane
Sa4125_05890	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Sa4125_05900	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Sa4125_05910	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Sa4125_05920	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Sa4125_05950	COG0521	Mo-molybdopterin cofactor biosynthetic process
Sa4125_05960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Sa4125_05980	COG0142	geranyltranstransferase activity
Sa4125_06030	COG0752	glycyl-tRNA synthetase alpha subunit
Sa4125_06040	COG2321	neutral zinc metallopeptidase
Sa4125_06060	COG0751	glycine-tRNA ligase activity
Sa4125_06080	COG0009	L-threonylcarbamoyladenylate synthase
Sa4125_06120	COG0151	Belongs to the GarS family
Sa4125_06130	COG1960	acyl-CoA dehydrogenase activity
Sa4125_06140	COG0179	Fumarylacetoacetate (FAA) hydrolase
Sa4125_06150	COG1960	acyl-CoA dehydrogenase activity
Sa4125_06160	COG1024	Enoyl-CoA hydratase
Sa4125_06200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Sa4125_06220	COG1722	exodeoxyribonuclease VII activity
Sa4125_06230	COG0123	including yeast histone deacetylase and acetoin utilization protein
Sa4125_06260	COG0406	alpha-ribazole phosphatase activity
Sa4125_06270	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Sa4125_06280	COG0484	heat shock protein binding
Sa4125_06300	COG0259	pyridoxamine-phosphate oxidase activity
Sa4125_06320	COG0312	modulator of DNA gyrase
Sa4125_06340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Sa4125_06350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Sa4125_06360	COG0109	protoheme IX farnesyltransferase activity
Sa4125_06410	COG3346	SURF1 family
Sa4125_06420	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Sa4125_06430	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Sa4125_06440	COG0328	RNA-DNA hybrid ribonuclease activity
Sa4125_06450	COG0678	peroxiredoxin activity
Sa4125_06450	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Sa4125_06470	COG1678	Uncharacterized ACR, COG1678
Sa4125_06480	COG5001	Diguanylate cyclase
Sa4125_06500	COG0612	Peptidase, M16
Sa4125_06530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Sa4125_06540	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Sa4125_06550	COG1011	Hydrolase
Sa4125_06560	COG1194	a g-specific adenine glycosylase
Sa4125_06590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Sa4125_06600	COG0574	Belongs to the PEP-utilizing enzyme family
Sa4125_06600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Sa4125_06620	COG0318	PFAM AMP-dependent synthetase and ligase
Sa4125_06650	COG1187	pseudouridine synthase activity
Sa4125_06670	COG1742	UPF0060 membrane protein
Sa4125_06680	COG0840	transmembrane signaling receptor activity
Sa4125_06710	COG3254	rhamnose metabolic process
Sa4125_06720	COG1063	alcohol dehydrogenase
Sa4125_06730	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_06760	COG1802	Transcriptional regulator
Sa4125_06770	COG0840	transmembrane signaling receptor activity
Sa4125_06810	COG3833	ABC-type maltose transport systems, permease component
Sa4125_06820	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_06840	COG3842	ATPase activity
Sa4125_06850	COG2188	Transcriptional regulator
Sa4125_06900	COG0765	amino acid transport
Sa4125_06910	COG1126	abc transporter atp-binding protein
Sa4125_06920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Sa4125_06940	COG0444	Belongs to the ABC transporter superfamily
Sa4125_06950	COG4608	Belongs to the ABC transporter superfamily
Sa4125_06970	COG0601	transmembrane transport
Sa4125_06980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_07000	COG3328	transposase activity
Sa4125_07010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa4125_07020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Sa4125_07020	COG1017	nitric oxide dioxygenase activity
Sa4125_07030	COG2346	COG2346, Truncated hemoglobins
Sa4125_07040	COG1959	2 iron, 2 sulfur cluster binding
Sa4125_07050	COG3328	transposase activity
Sa4125_07060	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Sa4125_07070	COG3485	protocatechuate 3,4-dioxygenase
Sa4125_07090	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Sa4125_07110	COG1609	Transcriptional regulator
Sa4125_07120	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_07140	COG1129	ABC transporter
Sa4125_07150	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_07160	COG2376	Dihydroxyacetone kinase
Sa4125_07180	COG0667	Aldo Keto reductase
Sa4125_07250	COG3328	transposase activity
Sa4125_07270	COG1295	ribonuclease BN
Sa4125_07290	COG1250	3-hydroxyacyl-CoA dehydrogenase
Sa4125_07290	COG1024	Enoyl-CoA hydratase
Sa4125_07300	COG2200	EAL domain
Sa4125_07300	COG2199	diguanylate cyclase activity
Sa4125_07300	COG2202	Pas domain
Sa4125_07320	COG0183	Belongs to the thiolase family
Sa4125_07340	COG1960	acyl-CoA dehydrogenase activity
Sa4125_07410	COG1201	RNA secondary structure unwinding
Sa4125_07440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Sa4125_07450	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_07470	COG3263	regulation of cellular component size
Sa4125_07510	COG0842	Transport permease protein
Sa4125_07520	COG1131	(ABC) transporter
Sa4125_07530	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Sa4125_07550	COG0625	glutathione transferase activity
Sa4125_07560	COG1692	metallophosphoesterase
Sa4125_07590	COG0217	transcriptional regulatory protein
Sa4125_07610	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Sa4125_07640	COG0632	four-way junction helicase activity
Sa4125_07670	COG2255	four-way junction helicase activity
Sa4125_07690	COG0824	Thioesterase
Sa4125_07710	COG0848	biopolymer transport protein
Sa4125_07730	COG0823	Involved in the tonB-independent uptake of proteins
Sa4125_07740	COG2885	chlorophyll binding
Sa4125_07770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Sa4125_07780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Sa4125_07790	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Sa4125_07810	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Sa4125_07830	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Sa4125_07850	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Sa4125_07880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Sa4125_07890	COG0564	pseudouridine synthase activity
Sa4125_07910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Sa4125_07940	COG1278	Cold shock
Sa4125_07960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Sa4125_07960	COG0357	Ribosomal RNA small subunit methyltransferase G
Sa4125_08010	COG0745	RESPONSE REGULATOR receiver
Sa4125_08050	COG0482	sulfurtransferase activity
Sa4125_08080	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Sa4125_08090	COG1278	Cold shock
Sa4125_08110	COG0784	Response regulator, receiver
Sa4125_08110	COG4191	Histidine kinase
Sa4125_08120	COG2202	Pas domain
Sa4125_08120	COG3920	Histidine kinase
Sa4125_08210	COG1063	alcohol dehydrogenase
Sa4125_08220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Sa4125_08220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Sa4125_08230	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Sa4125_08240	COG0861	Integral membrane protein TerC family
Sa4125_08250	COG0583	DNA-binding transcription factor activity
Sa4125_08300	COG3383	formate dehydrogenase (NAD+) activity
Sa4125_08310	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Sa4125_08410	COG0546	phosphoglycolate phosphatase activity
Sa4125_08450	COG1396	sequence-specific DNA binding
Sa4125_08470	COG0069	glutamate synthase activity
Sa4125_08480	COG2218	PFAM glutamate synthase alpha subunit domain protein
Sa4125_08490	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Sa4125_08510	COG4977	sequence-specific DNA binding
Sa4125_08520	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_08540	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sa4125_08540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Sa4125_08550	COG4311	Sarcosine oxidase, delta subunit
Sa4125_08560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa4125_08570	COG4977	sequence-specific DNA binding
Sa4125_08590	COG0010	Belongs to the arginase family
Sa4125_08610	COG2391	methyltransferase activity
Sa4125_08650	COG1090	epimerase
Sa4125_08660	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_08670	COG1129	ABC transporter
Sa4125_08700	COG0730	response to heat
Sa4125_08720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_08740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_08760	COG2186	Transcriptional regulator
Sa4125_08790	COG0473	3-isopropylmalate dehydrogenase activity
Sa4125_08810	COG0596	Alpha beta hydrolase
Sa4125_08840	COG0473	3-isopropylmalate dehydrogenase activity
Sa4125_08870	COG2186	Transcriptional regulator
Sa4125_08880	COG1178	ABC-type Fe3 transport system permease component
Sa4125_08900	COG3842	ATPase activity
Sa4125_08920	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_08970	COG1802	Transcriptional regulator
Sa4125_08980	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Sa4125_09030	COG3328	transposase activity
Sa4125_09040	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
Sa4125_09050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Sa4125_09100	COG3328	transposase activity
Sa4125_09140	COG3206	protein involved in exopolysaccharide biosynthesis
Sa4125_09140	COG0489	protein tyrosine kinase activity
Sa4125_09160	COG2963	transposase activity
Sa4125_09170	COG3436	PFAM IS66 Orf2 family protein
Sa4125_09180	COG2433	Pfam Transposase IS66
Sa4125_09190	COG2327	Polysaccharide pyruvyl transferase
Sa4125_09200	COG1215	transferase activity, transferring glycosyl groups
Sa4125_09240	COG1376	ErfK ybiS ycfS ynhG family protein
Sa4125_09270	COG0438	transferase activity, transferring glycosyl groups
Sa4125_09280	COG1215	transferase activity, transferring glycosyl groups
Sa4125_09290	COG1215	transferase activity, transferring glycosyl groups
Sa4125_09300	COG3307	-O-antigen
Sa4125_09310	COG3328	transposase activity
Sa4125_09330	COG4251	negative regulation of phosphorylation
Sa4125_09340	COG3328	transposase activity
Sa4125_09350	COG4251	negative regulation of phosphorylation
Sa4125_09360	COG3328	transposase activity
Sa4125_09370	COG3706	GGDEF domain
Sa4125_09370	COG5001	Diguanylate cyclase
Sa4125_09370	COG4251	negative regulation of phosphorylation
Sa4125_09370	COG2203	Gaf domain
Sa4125_09380	COG3293	Transposase
Sa4125_09440	COG1793	dna ligase
Sa4125_09470	COG0123	including yeast histone deacetylase and acetoin utilization protein
Sa4125_09480	COG0534	Mate efflux family protein
Sa4125_09490	COG0167	dihydroorotate dehydrogenase activity
Sa4125_09520	COG0657	acetylesterase activity
Sa4125_09530	COG0432	Pfam Uncharacterised protein family UPF0047
Sa4125_09560	COG2205	protein histidine kinase activity
Sa4125_09560	COG2198	Histidine kinase
Sa4125_09560	COG0784	Response regulator, receiver
Sa4125_09570	COG1970	mechanosensitive ion channel activity
Sa4125_09580	COG0436	Aminotransferase
Sa4125_09600	COG0156	8-amino-7-oxononanoate synthase activity
Sa4125_09640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Sa4125_09660	COG2204	response regulator
Sa4125_09690	COG1840	ABC-type Fe3 transport system, periplasmic component
Sa4125_09720	COG3842	ATPase activity
Sa4125_09780	COG3328	transposase activity
Sa4125_09850	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Sa4125_09860	COG4589	Belongs to the CDS family
Sa4125_09890	COG2124	cytochrome p450
Sa4125_09900	COG1309	transcriptional regulator
Sa4125_09920	COG0436	Aminotransferase
Sa4125_09950	COG5001	Diguanylate cyclase
Sa4125_09950	COG3300	MHYT domain
Sa4125_09970	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Sa4125_09980	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Sa4125_10050	COG3718	enzyme involved in inositol metabolism
Sa4125_10070	COG3962	Belongs to the TPP enzyme family
Sa4125_10080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_10090	COG0673	inositol 2-dehydrogenase activity
Sa4125_10120	COG0673	inositol 2-dehydrogenase activity
Sa4125_10140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Sa4125_10160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Sa4125_10290	COG0071	Belongs to the small heat shock protein (HSP20) family
Sa4125_10340	COG0069	glutamate synthase activity
Sa4125_10340	COG0070	glutamate synthase
Sa4125_10340	COG0067	glutamate synthase
Sa4125_10380	COG2951	lytic endotransglycosylase activity
Sa4125_10390	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Sa4125_10420	COG0330	HflC and HflK could
Sa4125_10450	COG3750	Belongs to the UPF0335 family
Sa4125_10460	COG4957	zinc ion binding
Sa4125_10490	COG5310	Homospermidine synthase
Sa4125_10530	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Sa4125_10550	COG0469	pyruvate kinase activity
Sa4125_10560	COG0457	Tetratricopeptide repeat
Sa4125_10570	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Sa4125_10580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Sa4125_10590	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Sa4125_10630	COG0352	thiamine-phosphate diphosphorylase activity
Sa4125_10660	COG0483	inositol monophosphate 1-phosphatase activity
Sa4125_10690	COG1132	(ABC) transporter
Sa4125_10700	COG0254	rRNA binding
Sa4125_10720	COG0129	dihydroxy-acid dehydratase activity
Sa4125_10730	COG0363	glucosamine-6-phosphate deaminase activity
Sa4125_10740	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Sa4125_10750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa4125_10810	COG2224	Isocitrate lyase
Sa4125_10870	COG3842	ATPase activity
Sa4125_10880	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_10890	COG1177	transmembrane transport
Sa4125_10920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Sa4125_10940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Sa4125_10940	COG4221	oxidoreductase activity
Sa4125_10940	COG0604	alcohol dehydrogenase
Sa4125_10940	COG3321	synthase
Sa4125_10980	COG5002	protein histidine kinase activity
Sa4125_10990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Sa4125_11000	COG0573	inorganic phosphate transmembrane transporter activity
Sa4125_11010	COG0581	inorganic phosphate transmembrane transporter activity
Sa4125_11020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Sa4125_11030	COG0704	Plays a role in the regulation of phosphate uptake
Sa4125_11040	COG0745	RESPONSE REGULATOR receiver
Sa4125_11070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Sa4125_11080	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Sa4125_11100	COG2967	ApaG domain
Sa4125_11110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Sa4125_11130	COG0717	Belongs to the dCTP deaminase family
Sa4125_11190	COG3328	transposase activity
Sa4125_11420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sa4125_11430	COG1335	isochorismatase
Sa4125_11460	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sa4125_11510	COG0174	glutamine synthetase
Sa4125_11520	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_11570	COG1509	lysine 2,3-aminomutase activity
Sa4125_11580	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Sa4125_11590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Sa4125_11630	COG3328	transposase activity
Sa4125_11640	COG3842	ATPase activity
Sa4125_11660	COG1840	ABC-type Fe3 transport system, periplasmic component
Sa4125_11700	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Sa4125_11720	COG0840	transmembrane signaling receptor activity
Sa4125_11750	COG2433	Pfam Transposase IS66
Sa4125_11760	COG3436	PFAM IS66 Orf2 family protein
Sa4125_11770	COG2963	transposase activity
Sa4125_11790	COG3328	transposase activity
Sa4125_11810	COG2801	Transposase and inactivated derivatives
Sa4125_11840	COG3328	transposase activity
Sa4125_11860	COG0840	transmembrane signaling receptor activity
Sa4125_11890	COG0583	DNA-binding transcription factor activity
Sa4125_11910	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Sa4125_11940	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_11950	COG1177	transmembrane transport
Sa4125_11970	COG1686	Belongs to the peptidase S11 family
Sa4125_12000	COG1309	transcriptional regulator
Sa4125_12030	COG0028	Belongs to the TPP enzyme family
Sa4125_12040	COG3300	MHYT domain
Sa4125_12040	COG5001	Diguanylate cyclase
Sa4125_12050	COG2373	Large extracellular alpha-helical protein
Sa4125_12060	COG4953	penicillin-binding protein 1C
Sa4125_12100	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Sa4125_12120	COG2166	iron-sulfur cluster assembly
Sa4125_12140	COG2205	protein histidine kinase activity
Sa4125_12210	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Sa4125_12220	COG2983	Belongs to the UPF0260 family
Sa4125_12250	COG4695	Portal protein
Sa4125_12500	COG4235	cytochrome complex assembly
Sa4125_12510	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Sa4125_12520	COG1138	Cytochrome C-type biogenesis protein
Sa4125_12530	COG3088	subunit of a heme lyase
Sa4125_12540	COG5001	Diguanylate cyclase
Sa4125_12540	COG4251	negative regulation of phosphorylation
Sa4125_12540	COG3706	GGDEF domain
Sa4125_12540	COG2203	Gaf domain
Sa4125_12560	COG0745	RESPONSE REGULATOR receiver
Sa4125_12580	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_12590	COG0642	Histidine kinase
Sa4125_12630	COG2897	thiosulfate sulfurtransferase activity
Sa4125_12640	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Sa4125_12660	COG0415	Belongs to the DNA photolyase family
Sa4125_12670	COG2205	protein histidine kinase activity
Sa4125_12670	COG2202	Pas domain
Sa4125_12680	COG0308	aminopeptidase N
Sa4125_12760	COG3328	transposase activity
Sa4125_12840	COG1573	uracil-dna glycosylase
Sa4125_12850	COG0596	Alpha beta hydrolase
Sa4125_12880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Sa4125_12930	COG0625	glutathione transferase activity
Sa4125_13000	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Sa4125_13010	COG0642	Histidine kinase
Sa4125_13040	COG0745	RESPONSE REGULATOR receiver
Sa4125_13060	COG3328	transposase activity
Sa4125_13080	COG0697	spore germination
Sa4125_13090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Sa4125_13130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Sa4125_13130	COG3743	rRNA binding
Sa4125_13140	COG0488	(ABC) transporter
Sa4125_13170	COG0251	oxidation-reduction process
Sa4125_13210	COG0105	UTP biosynthetic process
Sa4125_13240	COG0314	molybdopterin synthase activity
Sa4125_13280	COG0784	Response regulator, receiver
Sa4125_13290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Sa4125_13300	COG0322	excinuclease ABC activity
Sa4125_13320	COG0625	glutathione transferase activity
Sa4125_13350	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Sa4125_13370	COG1902	pentaerythritol trinitrate reductase activity
Sa4125_13390	COG0243	molybdopterin cofactor binding
Sa4125_13400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Sa4125_13410	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Sa4125_13420	COG0628	permease
Sa4125_13430	COG1484	DNA-dependent DNA replication
Sa4125_13440	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Sa4125_13470	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Sa4125_13480	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Sa4125_13490	COG3300	MHYT domain
Sa4125_13490	COG5001	Diguanylate cyclase
Sa4125_13510	COG1129	ABC transporter
Sa4125_13520	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_13530	COG1879	ABC-type sugar transport system periplasmic component
Sa4125_13550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Sa4125_13580	COG0741	lytic transglycosylase activity
Sa4125_13580	COG1196	nuclear chromosome segregation
Sa4125_13580	COG0739	heme binding
Sa4125_13600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Sa4125_13610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Sa4125_13620	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Sa4125_13630	COG0840	transmembrane signaling receptor activity
Sa4125_13640	COG1573	uracil-dna glycosylase
Sa4125_13660	COG1758	RNA polymerase activity
Sa4125_13680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Sa4125_13700	COG0736	holo-[acyl-carrier-protein] synthase activity
Sa4125_13710	COG0681	Belongs to the peptidase S26 family
Sa4125_13730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Sa4125_13760	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_13780	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Sa4125_13790	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Sa4125_13810	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Sa4125_13830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Sa4125_13860	COG0640	Transcriptional regulator
Sa4125_13880	COG0215	cysteine-tRNA ligase activity
Sa4125_13910	COG2267	carboxylic ester hydrolase activity
Sa4125_13920	COG1363	Peptidase, m42
Sa4125_14030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sa4125_14040	COG1733	regulation of RNA biosynthetic process
Sa4125_14080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Sa4125_14090	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Sa4125_14100	COG1122	ATPase activity
Sa4125_14110	COG1268	BioY protein
Sa4125_14210	COG3328	transposase activity
Sa4125_14230	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Sa4125_14270	COG0395	ABC-type sugar transport system, permease component
Sa4125_14290	COG3842	ATPase activity
Sa4125_14300	COG3842	ATPase activity
Sa4125_14350	COG1129	ABC transporter
Sa4125_14360	COG4214	carbohydrate transport
Sa4125_14370	COG4213	ABC transporter substrate-binding protein
Sa4125_14380	COG1940	carbohydrate kinase activity
Sa4125_14390	COG2115	Belongs to the xylose isomerase family
Sa4125_14400	COG1070	Carbohydrate kinase
Sa4125_14410	COG2205	protein histidine kinase activity
Sa4125_14430	COG0745	RESPONSE REGULATOR receiver
Sa4125_14440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Sa4125_14530	COG0175	sulfate reduction
Sa4125_14540	COG1216	Glycosyl transferase, family 2
Sa4125_14550	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Sa4125_14570	COG2801	Transposase and inactivated derivatives
Sa4125_14590	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
Sa4125_14630	COG3335	DDE superfamily endonuclease
Sa4125_14660	COG3328	transposase activity
Sa4125_14690	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Sa4125_14700	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Sa4125_14710	COG3959	Transketolase, thiamine diphosphate binding domain
Sa4125_14730	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Sa4125_14740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sa4125_14750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Sa4125_14860	COG2826	transposase and inactivated derivatives, IS30 family
Sa4125_15020	COG2226	methyltransferase
Sa4125_15050	COG3293	Transposase
Sa4125_15060	COG3328	transposase activity
Sa4125_15140	COG3328	transposase activity
Sa4125_15220	COG3328	transposase activity
Sa4125_15240	COG3920	Histidine kinase
Sa4125_15240	COG2202	Pas domain
Sa4125_15490	COG2826	transposase and inactivated derivatives, IS30 family
Sa4125_15500	COG2801	Transposase and inactivated derivatives
Sa4125_15510	COG3415	Transposase
Sa4125_15530	COG3335	DDE superfamily endonuclease
Sa4125_15550	COG3328	transposase activity
Sa4125_15590	COG5265	(ABC) transporter
Sa4125_15600	COG0688	phosphatidylethanolamine metabolic process
Sa4125_15610	COG1183	phosphatidylcholine synthase activity
Sa4125_15630	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Sa4125_15640	COG0546	phosphoglycolate phosphatase activity
Sa4125_15650	COG0517	IMP dehydrogenase activity
Sa4125_15650	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Sa4125_15660	COG4221	oxidoreductase activity
Sa4125_15670	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Sa4125_15710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Sa4125_15730	COG0359	binds to the 23S rRNA
Sa4125_15750	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Sa4125_15760	COG0360	Binds together with S18 to 16S ribosomal RNA
Sa4125_15770	COG3300	MHYT domain
Sa4125_15770	COG5001	Diguanylate cyclase
Sa4125_15780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Sa4125_15810	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Sa4125_15820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Sa4125_15830	COG1561	YicC-like family, N-terminal region
Sa4125_15840	COG0194	GDP metabolic process
Sa4125_15860	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Sa4125_15870	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Sa4125_15890	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Sa4125_15920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Sa4125_15940	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
Sa4125_15960	COG0113	porphobilinogen synthase activity
Sa4125_16000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Sa4125_16010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Sa4125_16040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa4125_16050	COG0765	amino acid transport
Sa4125_16060	COG1126	abc transporter atp-binding protein
Sa4125_16080	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Sa4125_16090	COG2814	Major facilitator Superfamily
Sa4125_16100	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Sa4125_16140	COG0416	fatty acid biosynthetic process
Sa4125_16150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Sa4125_16160	COG0776	regulation of translation
Sa4125_16230	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
Sa4125_16270	COG1596	polysaccharide export
Sa4125_16320	COG1612	heme a metabolic process
Sa4125_16330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Sa4125_16340	COG0010	Belongs to the arginase family
Sa4125_16350	COG3328	transposase activity
Sa4125_16370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Sa4125_16380	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Sa4125_16400	COG1832	CoA-binding protein
Sa4125_16430	COG2124	cytochrome p450
Sa4125_16460	COG3300	MHYT domain
Sa4125_16460	COG5001	Diguanylate cyclase
Sa4125_16480	COG3386	PFAM SMP-30 Gluconolaconase
Sa4125_16490	COG0800	Aldolase
Sa4125_16500	COG3734	2-keto-3-deoxy-galactonokinase
Sa4125_16510	COG0129	dihydroxy-acid dehydratase activity
Sa4125_16530	COG2186	Transcriptional regulator
Sa4125_16540	COG4213	ABC transporter substrate-binding protein
Sa4125_16560	COG4214	carbohydrate transport
Sa4125_16590	COG0671	phosphoesterase, PA-phosphatase related
Sa4125_16600	COG1335	isochorismatase
Sa4125_16640	COG0154	amidase activity
Sa4125_16660	COG0725	ABC transporter, periplasmic molybdate-binding protein
Sa4125_16670	COG4149	molybdate abc transporter
Sa4125_16680	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
Sa4125_16700	COG3842	ATPase activity
Sa4125_16830	COG0243	molybdopterin cofactor binding
Sa4125_16830	COG3383	formate dehydrogenase (NAD+) activity
Sa4125_16840	COG0437	4 iron, 4 sulfur cluster binding
Sa4125_16890	COG0303	'Molybdopterin
Sa4125_16910	COG0746	molybdenum cofactor guanylyltransferase activity
Sa4125_16920	COG0303	'Molybdopterin
Sa4125_16950	COG3842	ATPase activity
Sa4125_16990	COG0840	transmembrane signaling receptor activity
Sa4125_17000	COG0657	acetylesterase activity
Sa4125_17040	COG4172	Belongs to the ABC transporter superfamily
Sa4125_17050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_17070	COG0747	negative chemotaxis
Sa4125_17080	COG4977	sequence-specific DNA binding
Sa4125_17100	COG1250	3-hydroxyacyl-CoA dehydrogenase
Sa4125_17100	COG0824	Thioesterase
Sa4125_17220	COG1272	protein, Hemolysin III
Sa4125_17280	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Sa4125_17290	COG1802	Transcriptional regulator
Sa4125_17310	COG1335	isochorismatase
Sa4125_17320	COG3845	ABC transporter
Sa4125_17340	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Sa4125_17350	COG1079	Belongs to the binding-protein-dependent transport system permease family
Sa4125_17400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Sa4125_17410	COG1396	sequence-specific DNA binding
Sa4125_17410	COG1917	Cupin 2, conserved barrel domain protein
Sa4125_17430	COG3842	ATPase activity
Sa4125_17440	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_17450	COG1177	transmembrane transport
Sa4125_17490	COG3415	Transposase
Sa4125_17500	COG3335	DDE superfamily endonuclease
Sa4125_17550	COG0745	RESPONSE REGULATOR receiver
Sa4125_17590	COG2433	Pfam Transposase IS66
Sa4125_17600	COG3436	PFAM IS66 Orf2 family protein
Sa4125_17610	COG2963	transposase activity
Sa4125_17630	COG3328	transposase activity
Sa4125_17660	COG2801	Transposase and inactivated derivatives
Sa4125_17680	COG3328	transposase activity
Sa4125_17730	COG0789	Transcriptional regulator
Sa4125_17760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Sa4125_17780	COG3034	peptidoglycan biosynthetic process
Sa4125_17820	COG3328	transposase activity
Sa4125_17900	COG2847	Copper chaperone PCu(A)C
Sa4125_17910	COG1999	signal sequence binding
Sa4125_17960	COG1914	H( )-stimulated, divalent metal cation uptake system
Sa4125_17970	COG1742	UPF0060 membrane protein
Sa4125_18000	COG2801	Transposase and inactivated derivatives
Sa4125_18020	COG1238	metal cluster binding
Sa4125_18030	COG2814	Major facilitator Superfamily
Sa4125_18040	COG1937	Protein conserved in bacteria
Sa4125_18130	COG5001	Diguanylate cyclase
Sa4125_18130	COG4251	negative regulation of phosphorylation
Sa4125_18130	COG3706	GGDEF domain
Sa4125_18130	COG2203	Gaf domain
Sa4125_18140	COG5001	Diguanylate cyclase
Sa4125_18150	COG3328	transposase activity
Sa4125_18260	COG2217	Heavy metal translocating P-type atpase
Sa4125_18270	COG0789	Transcriptional regulator
Sa4125_18300	COG2217	Heavy metal translocating P-type atpase
Sa4125_18370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Sa4125_18380	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Sa4125_18430	COG3328	transposase activity
Sa4125_18490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Sa4125_18500	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Sa4125_18510	COG1058	Belongs to the CinA family
Sa4125_18510	COG1546	Belongs to the CinA family
Sa4125_18520	COG0655	NAD(P)H dehydrogenase (quinone) activity
Sa4125_18540	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Sa4125_18550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Sa4125_18560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Sa4125_18590	COG0686	Belongs to the AlaDH PNT family
Sa4125_18600	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Sa4125_18620	COG3328	transposase activity
Sa4125_18670	COG3639	organic phosphonate transmembrane transporter activity
Sa4125_18680	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Sa4125_18710	COG1840	ABC-type Fe3 transport system, periplasmic component
Sa4125_18730	COG3842	ATPase activity
Sa4125_18740	COG0483	inositol monophosphate 1-phosphatase activity
Sa4125_18760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Sa4125_18810	COG0129	dihydroxy-acid dehydratase activity
Sa4125_18840	COG0316	Belongs to the HesB IscA family
Sa4125_18850	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Sa4125_18860	COG0018	arginyl-trna synthetase
Sa4125_18890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Sa4125_18900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Sa4125_18910	COG0805	protein transport
Sa4125_18920	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Sa4125_18930	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Sa4125_18940	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Sa4125_18970	COG1862	Preprotein translocase
Sa4125_19010	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Sa4125_19030	COG0544	peptidyl-prolyl cis-trans isomerase activity
Sa4125_19040	COG0668	transmembrane transport
Sa4125_19050	COG0740	serine-type endopeptidase activity
Sa4125_19060	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Sa4125_19080	COG0776	regulation of translation
Sa4125_19090	COG2814	Major facilitator Superfamily
Sa4125_19110	COG2423	ornithine cyclodeaminase activity
Sa4125_19130	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Sa4125_19150	COG4608	Belongs to the ABC transporter superfamily
Sa4125_19170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_19190	COG2267	carboxylic ester hydrolase activity
Sa4125_19210	COG0683	leucine binding
Sa4125_19230	COG0667	Aldo Keto reductase
Sa4125_19280	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sa4125_19300	COG0667	Aldo Keto reductase
Sa4125_19330	COG1177	transmembrane transport
Sa4125_19340	COG3842	ATPase activity
Sa4125_19360	COG2226	methyltransferase
Sa4125_19400	COG1960	acyl-CoA dehydrogenase activity
Sa4125_19440	COG3665	Urea carboxylase-associated protein
Sa4125_19480	COG1793	dna ligase
Sa4125_19490	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_19510	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_19520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_19540	COG1082	Xylose isomerase domain protein TIM barrel
Sa4125_19560	COG1175	transmembrane transport
Sa4125_19590	COG1063	alcohol dehydrogenase
Sa4125_19600	COG3842	ATPase activity
Sa4125_19610	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_19620	COG1879	ABC-type sugar transport system periplasmic component
Sa4125_19650	COG4702	Belongs to the UPF0303 family
Sa4125_19660	COG1940	carbohydrate kinase activity
Sa4125_19690	COG0673	inositol 2-dehydrogenase activity
Sa4125_19700	COG1940	carbohydrate kinase activity
Sa4125_19710	COG3842	ATPase activity
Sa4125_19720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Sa4125_19730	COG0395	ABC-type sugar transport system, permease component
Sa4125_19740	COG1175	transmembrane transport
Sa4125_19770	COG1349	DNA-binding transcription factor activity
Sa4125_19780	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
Sa4125_19820	COG3158	transport of potassium into the cell
Sa4125_19830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sa4125_19840	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sa4125_19850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sa4125_19870	COG0649	NAD binding
Sa4125_19890	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Sa4125_19900	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Sa4125_19940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Sa4125_19960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Sa4125_19980	COG0713	ATP synthesis coupled electron transport
Sa4125_20010	COG1007	ATP synthesis coupled electron transport
Sa4125_20040	COG0346	lactoylglutathione lyase activity
Sa4125_20060	COG0442	prolyl-tRNA aminoacylation
Sa4125_20080	COG1136	(ABC) transporter
Sa4125_20100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Sa4125_20130	COG0784	Response regulator, receiver
Sa4125_20150	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Sa4125_20190	COG0557	exoribonuclease II activity
Sa4125_20200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Sa4125_20220	COG0758	DNA mediated transformation
Sa4125_20230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Sa4125_20240	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Sa4125_20280	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Sa4125_20290	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Sa4125_20300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Sa4125_20360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Sa4125_20400	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Sa4125_20420	COG0511	ligase activity, forming carbon-carbon bonds
Sa4125_20440	COG0501	Belongs to the peptidase M48B family
Sa4125_20460	COG0436	Aminotransferase
Sa4125_20470	COG1530	ribonuclease E activity
Sa4125_20480	COG0860	N-Acetylmuramoyl-L-alanine amidase
Sa4125_20510	COG0739	heme binding
Sa4125_20530	COG2833	Protein of unknown function (DUF455)
Sa4125_20540	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Sa4125_20560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Sa4125_20570	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Sa4125_20580	COG2945	thiolester hydrolase activity
Sa4125_20590	COG1104	cysteine desulfurase activity
Sa4125_20600	COG0719	Fe-S assembly protein
Sa4125_20620	COG0396	ATPase activity
Sa4125_20630	COG0719	Fe-S assembly protein
Sa4125_20640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Sa4125_20650	COG2151	metal-sulfur cluster biosynthetic enzyme
Sa4125_20660	COG0316	Belongs to the HesB IscA family
Sa4125_20700	COG0187	DNA topoisomerase II activity
Sa4125_20750	COG2095	MarC family integral membrane protein
Sa4125_20760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Sa4125_20780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Sa4125_20810	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Sa4125_20820	COG0343	queuine tRNA-ribosyltransferase activity
Sa4125_20870	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Sa4125_20880	COG2354	Protein conserved in bacteria
Sa4125_20910	COG0582	viral genome integration into host DNA
Sa4125_21030	COG0270	DNA (cytosine-5-)-methyltransferase activity
Sa4125_21040	COG0785	Cytochrome C biogenesis protein
Sa4125_21050	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Sa4125_21060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Sa4125_21090	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Sa4125_21110	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Sa4125_21130	COG4166	transmembrane transport
Sa4125_21160	COG0679	Auxin Efflux Carrier
Sa4125_21170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Sa4125_21180	COG1183	phosphatidylcholine synthase activity
Sa4125_21210	COG1295	ribonuclease BN
Sa4125_21250	COG3707	response regulator
Sa4125_21270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Sa4125_21280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_21290	COG1116	anion transmembrane transporter activity
Sa4125_21300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Sa4125_21310	COG2146	nitrite reductase [NAD(P)H] activity
Sa4125_21320	COG0243	molybdopterin cofactor binding
Sa4125_21330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Sa4125_21330	COG1648	precorrin-2 dehydrogenase activity
Sa4125_21360	COG1238	metal cluster binding
Sa4125_21430	COG3453	Protein conserved in bacteria
Sa4125_21430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sa4125_21440	COG0730	response to heat
Sa4125_21450	COG2391	methyltransferase activity
Sa4125_21470	COG0640	Transcriptional regulator
Sa4125_21480	COG1477	protein flavinylation
Sa4125_21560	COG3328	transposase activity
Sa4125_21590	COG3443	Belongs to the bacterial solute-binding protein 9 family
Sa4125_21600	COG0803	Belongs to the bacterial solute-binding protein 9 family
Sa4125_21610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sa4125_21630	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Sa4125_21650	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Sa4125_21650	COG0321	lipoyl(octanoyl) transferase activity
Sa4125_21660	COG0084	hydrolase, TatD family'
Sa4125_21690	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Sa4125_21700	COG1686	Belongs to the peptidase S11 family
Sa4125_21760	COG2433	Pfam Transposase IS66
Sa4125_21770	COG3436	PFAM IS66 Orf2 family protein
Sa4125_21780	COG2963	transposase activity
Sa4125_21820	COG3920	Histidine kinase
Sa4125_21840	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Sa4125_21850	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Sa4125_21880	COG2205	protein histidine kinase activity
Sa4125_21890	COG0745	RESPONSE REGULATOR receiver
Sa4125_21970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Sa4125_21990	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Sa4125_22000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Sa4125_22020	COG3956	TIGRFAM MazG family protein
Sa4125_22030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Sa4125_22040	COG1923	regulation of RNA biosynthetic process
Sa4125_22050	COG2204	response regulator
Sa4125_22060	COG5000	phosphorelay sensor kinase activity
Sa4125_22070	COG2204	response regulator
Sa4125_22080	COG3852	Histidine kinase
Sa4125_22100	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Sa4125_22100	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Sa4125_22110	COG1546	Belongs to the CinA family
Sa4125_22110	COG1058	Belongs to the CinA family
Sa4125_22120	COG2867	negative regulation of translational initiation
Sa4125_22130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Sa4125_22150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Sa4125_22170	COG0508	dehydrogenase complex catalyzes the overall conversion of
Sa4125_22180	COG0022	dehydrogenase e1 component
Sa4125_22180	COG0508	dehydrogenase complex catalyzes the overall conversion of
Sa4125_22190	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Sa4125_22200	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Sa4125_22210	COG2116	formate transmembrane transporter activity
Sa4125_22220	COG0148	phosphopyruvate hydratase activity
Sa4125_22240	COG0504	CTP synthase activity
Sa4125_22260	COG0149	triose-phosphate isomerase activity
Sa4125_22270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Sa4125_22280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Sa4125_22290	COG0134	indole-3-glycerol-phosphate synthase activity
Sa4125_22300	COG0315	cyclic pyranopterin monophosphate synthase activity
Sa4125_22310	COG0303	'Molybdopterin
Sa4125_22320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Sa4125_22350	COG0372	Belongs to the citrate synthase family
Sa4125_22360	COG0629	single-stranded DNA binding
Sa4125_22370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Sa4125_22410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Sa4125_22410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Sa4125_22420	COG0347	Belongs to the P(II) protein family
Sa4125_22430	COG0174	glutamine synthetase
Sa4125_22440	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Sa4125_22460	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Sa4125_22470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Sa4125_22480	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Sa4125_22490	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Sa4125_22500	COG0750	zinc metalloprotease
Sa4125_22520	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Sa4125_22540	COG0528	UMP kinase activity
Sa4125_22550	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Sa4125_22560	COG0052	Belongs to the universal ribosomal protein uS2 family
Sa4125_22610	COG0537	adenosine 5'-monophosphoramidase activity
Sa4125_22650	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Sa4125_22660	COG1686	Belongs to the peptidase S11 family
Sa4125_22740	COG2197	response regulator
Sa4125_22790	COG1222	aaa ATPase
Sa4125_22890	COG3328	transposase activity
Sa4125_22980	COG2239	Acts as a magnesium transporter
Sa4125_23010	COG0321	lipoyl(octanoyl) transferase activity
Sa4125_23020	COG1254	Belongs to the acylphosphatase family
Sa4125_23030	COG4770	biotin carboxylase activity
Sa4125_23050	COG1671	Belongs to the UPF0178 family
Sa4125_23060	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
Sa4125_23070	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Sa4125_23080	COG3706	GGDEF domain
Sa4125_23090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Sa4125_23110	COG0546	phosphoglycolate phosphatase activity
Sa4125_23130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Sa4125_23150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Sa4125_23180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sa4125_23190	COG0203	ribosomal protein L17
Sa4125_23210	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Sa4125_23220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Sa4125_23230	COG0563	adenylate kinase activity
Sa4125_23250	COG0200	Binds to the 23S rRNA
Sa4125_23260	COG1841	ribosomal large subunit assembly
Sa4125_23270	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Sa4125_23280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Sa4125_23310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Sa4125_23320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Sa4125_23330	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Sa4125_23340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Sa4125_23350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Sa4125_23370	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Sa4125_23400	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Sa4125_23420	COG0089	rRNA binding
Sa4125_23430	COG0088	Forms part of the polypeptide exit tunnel
Sa4125_23460	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Sa4125_23470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Sa4125_23480	COG0049	tRNA binding
Sa4125_23490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Sa4125_23500	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Sa4125_23510	COG0085	RNA polymerase activity
Sa4125_23520	COG0222	ribosome binding
Sa4125_23530	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Sa4125_23540	COG0081	regulation of translation
Sa4125_23550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Sa4125_23620	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Sa4125_23630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Sa4125_23650	COG0735	belongs to the Fur family
Sa4125_23660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Sa4125_23670	COG1121	(ABC) transporter
Sa4125_23710	COG1959	2 iron, 2 sulfur cluster binding
Sa4125_23720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa4125_23730	COG0673	inositol 2-dehydrogenase activity
Sa4125_23750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_23760	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_23770	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Sa4125_23780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sa4125_23790	COG1079	Belongs to the binding-protein-dependent transport system permease family
Sa4125_23800	COG4603	Belongs to the binding-protein-dependent transport system permease family
Sa4125_23810	COG3845	ABC transporter
Sa4125_23850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Sa4125_23880	COG1250	3-hydroxyacyl-CoA dehydrogenase
Sa4125_23890	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Sa4125_23900	COG0235	Class ii aldolase
Sa4125_23950	COG2945	thiolester hydrolase activity
Sa4125_23950	COG0596	Alpha beta hydrolase
Sa4125_23960	COG2188	Transcriptional regulator
Sa4125_23980	COG3328	transposase activity
Sa4125_24020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_24050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Sa4125_24100	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_24120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_24140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa4125_24150	COG0765	amino acid transport
Sa4125_24160	COG0765	amino acid transport
Sa4125_24200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_24210	COG1116	anion transmembrane transporter activity
Sa4125_24230	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_24270	COG0402	S-adenosylhomocysteine deaminase activity
Sa4125_24300	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_24310	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_24320	COG3842	ATPase activity
Sa4125_24330	COG0402	S-adenosylhomocysteine deaminase activity
Sa4125_24380	COG3706	GGDEF domain
Sa4125_24430	COG2358	TRAP transporter, solute receptor (TAXI family
Sa4125_24460	COG3328	transposase activity
Sa4125_24500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Sa4125_24510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Sa4125_24570	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Sa4125_24590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Sa4125_24610	COG0302	gtp cyclohydrolase
Sa4125_24620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Sa4125_24630	COG1752	Esterase of the alpha-beta hydrolase superfamily
Sa4125_24640	COG0516	GMP reductase activity
Sa4125_24640	COG0517	IMP dehydrogenase activity
Sa4125_24740	COG0628	permease
Sa4125_24750	COG1126	abc transporter atp-binding protein
Sa4125_24760	COG0765	amino acid transport
Sa4125_24770	COG4597	amino acid ABC transporter
Sa4125_24780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa4125_24790	COG0626	cystathionine gamma-synthase activity
Sa4125_24800	COG2824	Alkylphosphonate utilization operon protein PhnA
Sa4125_25010	COG3328	transposase activity
Sa4125_25040	COG4381	Mu-like prophage protein gp46
Sa4125_25350	COG3328	transposase activity
Sa4125_25450	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Sa4125_25470	COG3750	Belongs to the UPF0335 family
Sa4125_25610	COG3335	DDE superfamily endonuclease
Sa4125_25620	COG3335	DDE superfamily endonuclease
Sa4125_25630	COG3415	Transposase
Sa4125_25670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa4125_25720	COG0346	lactoylglutathione lyase activity
Sa4125_25760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Sa4125_25790	COG0436	Aminotransferase
Sa4125_25810	COG3243	poly(R)-hydroxyalkanoic acid synthase
Sa4125_25820	COG0024	Methionine aminopeptidase
Sa4125_25830	COG2003	Belongs to the UPF0758 family
Sa4125_25840	COG5425	PFAM Usg family protein
Sa4125_25850	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_25870	COG2068	MobA-Related Protein
Sa4125_25880	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Sa4125_25920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Sa4125_25930	COG0683	leucine binding
Sa4125_25940	COG3191	aminopeptidase activity
Sa4125_25960	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Sa4125_25990	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Sa4125_26030	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Sa4125_26040	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Sa4125_26060	COG0047	phosphoribosylformylglycinamidine synthase activity
Sa4125_26090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Sa4125_26120	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Sa4125_26130	COG2814	Major facilitator Superfamily
Sa4125_26140	COG0483	inositol monophosphate 1-phosphatase activity
Sa4125_26150	COG0037	tRNA processing
Sa4125_26160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Sa4125_26190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Sa4125_26210	COG0538	isocitrate dehydrogenase activity
Sa4125_26230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Sa4125_26250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Sa4125_26250	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Sa4125_26260	COG2313	pseudouridylate synthase activity
Sa4125_26310	COG3106	COG3106 Predicted ATPase
Sa4125_26320	COG3768	UPF0283 membrane protein
Sa4125_26340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Sa4125_26350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Sa4125_26370	COG0633	Ferredoxin
Sa4125_26400	COG3755	Protein conserved in bacteria
Sa4125_26410	COG3218	ABC-type transport auxiliary lipoprotein component
Sa4125_26410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Sa4125_26430	COG1127	ABC transporter
Sa4125_26450	COG4948	Mandelate Racemase Muconate Lactonizing
Sa4125_26460	COG0438	transferase activity, transferring glycosyl groups
Sa4125_26480	COG0281	malic enzyme
Sa4125_26480	COG0280	phosphate acetyltransferase
Sa4125_26570	COG3328	transposase activity
Sa4125_26580	COG3384	dioxygenase
Sa4125_26590	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Sa4125_26630	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Sa4125_26660	COG2205	protein histidine kinase activity
Sa4125_26660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa4125_26740	COG1228	amidohydrolase
Sa4125_26810	COG1126	abc transporter atp-binding protein
Sa4125_26820	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_26890	COG0252	asparaginase activity
Sa4125_26960	COG0714	Associated with various cellular activities
Sa4125_27060	COG2188	Transcriptional regulator
Sa4125_27070	COG1063	alcohol dehydrogenase
Sa4125_27080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Sa4125_27100	COG1177	transmembrane transport
Sa4125_27110	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Sa4125_27120	COG3842	ATPase activity
Sa4125_27130	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_27200	COG2963	transposase activity
Sa4125_27220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_27230	COG1116	anion transmembrane transporter activity
Sa4125_27270	COG0154	amidase activity
Sa4125_27310	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sa4125_27370	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_27380	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_27390	COG1129	ABC transporter
Sa4125_27490	COG0644	oxidoreductase
Sa4125_27500	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Sa4125_27540	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sa4125_27550	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sa4125_27560	COG1429	ligase activity, forming nitrogen-metal bonds
Sa4125_27570	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Sa4125_27590	COG2814	Major facilitator Superfamily
Sa4125_27640	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
Sa4125_27660	COG0156	8-amino-7-oxononanoate synthase activity
Sa4125_27730	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sa4125_27740	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
Sa4125_27750	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
Sa4125_27760	COG1063	alcohol dehydrogenase
Sa4125_27770	COG0500	methyltransferase
Sa4125_27780	COG0142	geranyltranstransferase activity
Sa4125_27820	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Sa4125_27850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Sa4125_27870	COG4566	intracellular signal transduction
Sa4125_27880	COG4251	negative regulation of phosphorylation
Sa4125_27920	COG2186	Transcriptional regulator
Sa4125_27930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Sa4125_27940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa4125_27950	COG3938	Belongs to the proline racemase family
Sa4125_27990	COG3842	ATPase activity
Sa4125_28000	COG0395	ABC-type sugar transport system, permease component
Sa4125_28010	COG1175	transmembrane transport
Sa4125_28020	COG1653	transport
Sa4125_28030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Sa4125_28040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa4125_28060	COG1228	amidohydrolase
Sa4125_28070	COG2986	histidine ammonia-lyase
Sa4125_28100	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Sa4125_28140	COG0628	permease
Sa4125_28170	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Sa4125_28180	COG0351	phosphomethylpyrimidine kinase
Sa4125_28230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Sa4125_28310	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Sa4125_28330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Sa4125_28360	COG0395	ABC-type sugar transport system, permease component
Sa4125_28370	COG1175	transmembrane transport
Sa4125_28410	COG2308	Evidence 4 Homologs of previously reported genes of
Sa4125_28440	COG3706	GGDEF domain
Sa4125_28460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Sa4125_28490	COG0697	spore germination
Sa4125_28530	COG2084	Dehydrogenase
Sa4125_28550	COG1522	sequence-specific DNA binding
Sa4125_28560	COG0625	glutathione transferase activity
Sa4125_28570	COG2202	Pas domain
Sa4125_28570	COG2205	protein histidine kinase activity
Sa4125_28590	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Sa4125_28610	COG3328	transposase activity
Sa4125_28640	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Sa4125_28660	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Sa4125_28700	COG5001	Diguanylate cyclase
Sa4125_28710	COG3328	transposase activity
Sa4125_28730	COG4176	ABC-type proline glycine betaine transport system permease component
Sa4125_28740	COG0517	IMP dehydrogenase activity
Sa4125_28740	COG4175	Glycine betaine
Sa4125_28760	COG3932	Exopolysaccharide synthesis, ExoD
Sa4125_28840	COG1088	dTDP-glucose 4,6-dehydratase activity
Sa4125_28870	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Sa4125_28870	COG0546	phosphoglycolate phosphatase activity
Sa4125_28880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Sa4125_28930	COG1177	transmembrane transport
Sa4125_28940	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_28950	COG3842	ATPase activity
Sa4125_28960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Sa4125_28970	COG0583	DNA-binding transcription factor activity
Sa4125_28980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Sa4125_29050	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Sa4125_29060	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Sa4125_29070	COG3328	transposase activity
Sa4125_29140	COG0367	asparagine synthase
Sa4125_29150	COG0189	ligase activity
Sa4125_29150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Sa4125_29160	COG1363	Peptidase, m42
Sa4125_29170	COG0659	secondary active sulfate transmembrane transporter activity
Sa4125_29180	COG0589	response to stress
Sa4125_29210	COG1819	glycosyl
Sa4125_29260	COG4548	von Willebrand factor, type A
Sa4125_29270	COG3328	transposase activity
Sa4125_29290	COG0714	Associated with various cellular activities
Sa4125_29310	COG2010	Cytochrome c
Sa4125_29330	COG3328	transposase activity
Sa4125_29440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Sa4125_29460	COG3328	transposase activity
Sa4125_29490	COG2151	metal-sulfur cluster biosynthetic enzyme
Sa4125_29560	COG4172	Belongs to the ABC transporter superfamily
Sa4125_29580	COG0601	transmembrane transport
Sa4125_29620	COG0251	oxidation-reduction process
Sa4125_30520	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Sa4125_30540	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Sa4125_30560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Sa4125_30620	COG0440	acetolactate synthase activity
Sa4125_30640	COG0028	Belongs to the TPP enzyme family
Sa4125_30670	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Sa4125_30680	COG0560	Phosphoserine phosphatase
Sa4125_30680	COG3830	Belongs to the UPF0237 family
Sa4125_30740	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Sa4125_30750	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
Sa4125_30760	COG2202	Pas domain
Sa4125_30760	COG3920	Histidine kinase
Sa4125_30820	COG2814	Major facilitator Superfamily
Sa4125_30840	COG3328	transposase activity
Sa4125_30850	COG0784	Response regulator, receiver
Sa4125_30850	COG4191	Histidine kinase
Sa4125_30900	COG0277	FAD linked oxidase domain protein
Sa4125_30920	COG4297	protein containing double-stranded beta helix domain
Sa4125_30930	COG0412	Dienelactone hydrolase
Sa4125_30940	COG0210	DNA helicase
Sa4125_30980	COG2814	Major facilitator Superfamily
Sa4125_31000	COG1999	signal sequence binding
Sa4125_31010	COG2264	protein methyltransferase activity
Sa4125_31030	COG0006	proline dipeptidase activity
Sa4125_31050	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Sa4125_31170	COG2176	DNA-directed DNA polymerase activity
Sa4125_31180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Sa4125_31190	COG0497	DNA recombination
Sa4125_31200	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Sa4125_31220	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Sa4125_31230	COG0849	cell division
Sa4125_31240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Sa4125_31250	COG1181	Belongs to the D-alanine--D-alanine ligase family
Sa4125_31270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Sa4125_31280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Sa4125_31300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Sa4125_31330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Sa4125_31360	COG0275	rRNA processing
Sa4125_31370	COG2001	Belongs to the MraZ family
Sa4125_31380	COG3023	N-Acetylmuramoyl-L-alanine amidase
Sa4125_31390	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Sa4125_31500	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Sa4125_31540	COG0154	amidase activity
Sa4125_31550	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Sa4125_31560	COG2226	methyltransferase
Sa4125_31570	COG1720	tRNA m6t6A37 methyltransferase activity
Sa4125_31590	COG1597	lipid kinase activity
Sa4125_31640	COG0586	Pfam SNARE associated Golgi protein
Sa4125_31670	COG3920	Histidine kinase
Sa4125_31700	COG2267	carboxylic ester hydrolase activity
Sa4125_31790	COG0714	Associated with various cellular activities
Sa4125_31820	COG2188	Transcriptional regulator
Sa4125_31830	COG3624	Phosphonate C-P lyase system protein PhnG
Sa4125_31840	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
Sa4125_31850	COG3626	phosphonate metabolism
Sa4125_31860	COG1598	PFAM Uncharacterised protein family UPF0150
Sa4125_31870	COG3627	carbon phosphorus lyase activity
Sa4125_31900	COG4107	phosphonate C-P lyase system protein PhnK
Sa4125_31910	COG4778	phosphonate C-P lyase system protein PhnL
Sa4125_31940	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Sa4125_31950	COG3639	organic phosphonate transmembrane transporter activity
Sa4125_31960	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Sa4125_31970	COG3454	Phosphonate metabolism
Sa4125_31980	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Sa4125_31980	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Sa4125_32020	COG3158	transport of potassium into the cell
Sa4125_32060	COG3328	transposase activity
Sa4125_32110	COG1566	PFAM secretion protein HlyD family protein
Sa4125_32150	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_32170	COG2094	Belongs to the DNA glycosylase MPG family
Sa4125_32180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Sa4125_32190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Sa4125_32200	COG0546	phosphoglycolate phosphatase activity
Sa4125_32210	COG2186	Transcriptional regulator
Sa4125_32220	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Sa4125_32230	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Sa4125_32240	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Sa4125_32250	COG4191	Histidine kinase
Sa4125_32260	COG4566	intracellular signal transduction
Sa4125_32270	COG0745	RESPONSE REGULATOR receiver
Sa4125_32280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Sa4125_32330	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Sa4125_32340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sa4125_32350	COG4558	Periplasmic binding protein
Sa4125_32370	COG4771	TonB-dependent receptor
Sa4125_32380	COG2329	Antibiotic biosynthesis monooxygenase
Sa4125_32400	COG1129	ABC transporter
Sa4125_32410	COG1879	ABC-type sugar transport system periplasmic component
Sa4125_32420	COG2113	Glycine betaine
Sa4125_32430	COG4175	Glycine betaine
Sa4125_32430	COG3448	diguanylate cyclase activity
Sa4125_32440	COG4176	ABC-type proline glycine betaine transport system permease component
Sa4125_32490	COG1396	sequence-specific DNA binding
Sa4125_32500	COG4638	Rieske (2fe-2S)
Sa4125_32510	COG0235	Class ii aldolase
Sa4125_32530	COG1312	Catalyzes the dehydration of D-mannonate
Sa4125_32560	COG3852	Histidine kinase
Sa4125_32600	COG0303	'Molybdopterin
Sa4125_32610	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Sa4125_32640	COG0154	amidase activity
Sa4125_32680	COG1850	ribulose-bisphosphate carboxylase activity
Sa4125_32690	COG2186	Transcriptional regulator
Sa4125_32710	COG4211	Belongs to the binding-protein-dependent transport system permease family
Sa4125_32720	COG1129	ABC transporter
Sa4125_32730	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_32740	COG0287	Prephenate dehydrogenase
Sa4125_32750	COG0673	inositol 2-dehydrogenase activity
Sa4125_32780	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_32790	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_32820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Sa4125_32830	COG2942	2-epimerase
Sa4125_32900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_32920	COG0154	amidase activity
Sa4125_32950	COG1176	ABC-type spermidine putrescine transport system, permease component I
Sa4125_32960	COG3842	ATPase activity
Sa4125_33020	COG2968	Membrane
Sa4125_33040	COG5001	Diguanylate cyclase
Sa4125_33040	COG3300	MHYT domain
Sa4125_33060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Sa4125_33100	COG1380	Effector of murein hydrolase LrgA
Sa4125_33110	COG1346	cytolysis
Sa4125_33150	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Sa4125_33160	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Sa4125_33190	COG0492	ferredoxin-NADP+ reductase activity
Sa4125_33230	COG0436	Aminotransferase
Sa4125_33260	COG1607	acyl-coa hydrolase
Sa4125_33330	COG0556	nucleotide-excision repair
Sa4125_33370	COG1278	Cold shock
Sa4125_33380	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Sa4125_33390	COG1278	Cold shock
Sa4125_33410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sa4125_33430	COG1846	Transcriptional regulator
Sa4125_33440	COG0745	RESPONSE REGULATOR receiver
Sa4125_33470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Sa4125_33520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Sa4125_33540	COG1496	oxidoreductase activity
Sa4125_33550	COG0024	Methionine aminopeptidase
Sa4125_33580	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Sa4125_33590	COG0598	Magnesium transport protein CorA
Sa4125_33600	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Sa4125_33610	COG0193	aminoacyl-tRNA hydrolase activity
Sa4125_33630	COG0012	GTP binding
Sa4125_33680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Sa4125_33690	COG2857	Cytochrome c1
Sa4125_33690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Sa4125_33720	COG1132	(ABC) transporter
Sa4125_33730	COG1132	(ABC) transporter
Sa4125_33740	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Sa4125_33760	COG4106	trans-aconitate 2-methyltransferase activity
Sa4125_33770	COG3047	cAMP biosynthetic process
Sa4125_33790	COG0408	coproporphyrinogen oxidase activity
Sa4125_33810	COG0617	tRNA 3'-terminal CCA addition
Sa4125_33840	COG0714	Associated with various cellular activities
Sa4125_33890	COG0435	Glutathione S-transferase
Sa4125_33920	COG3135	benzoate transporter
Sa4125_33940	COG0508	dehydrogenase complex catalyzes the overall conversion of
Sa4125_33940	COG0596	Alpha beta hydrolase
Sa4125_33950	COG0028	Belongs to the TPP enzyme family
Sa4125_33960	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Sa4125_33970	COG3920	Histidine kinase
Sa4125_33980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Sa4125_33990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Sa4125_33990	COG0512	Glutamine amidotransferase of anthranilate synthase
Sa4125_34010	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Sa4125_34020	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Sa4125_34030	COG1733	regulation of RNA biosynthetic process
Sa4125_34060	COG5507	3-demethylubiquinone-9 3-methyltransferase
Sa4125_34130	COG4175	Glycine betaine
Sa4125_34140	COG4608	Belongs to the ABC transporter superfamily
Sa4125_34150	COG0444	Belongs to the ABC transporter superfamily
Sa4125_34170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_34180	COG0601	transmembrane transport
Sa4125_34200	COG0747	negative chemotaxis
Sa4125_34210	COG0489	protein tyrosine kinase activity
Sa4125_34250	COG2202	Pas domain
Sa4125_34250	COG3920	Histidine kinase
Sa4125_34260	COG0784	Response regulator, receiver
Sa4125_34330	COG1597	lipid kinase activity
Sa4125_34370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Sa4125_34380	COG0488	(ABC) transporter
Sa4125_34390	COG3328	transposase activity
Sa4125_34440	COG3328	transposase activity
Sa4125_34470	COG0513	Belongs to the DEAD box helicase family
Sa4125_34570	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Sa4125_34630	COG4794	Type iii secretion
Sa4125_34650	COG5443	negative regulation of bacterial-type flagellum assembly
Sa4125_34660	COG5442	Flagellar protein FlaF
Sa4125_34750	COG1766	The M ring may be actively involved in energy transduction
Sa4125_34770	COG1338	Plays a role in the flagellum-specific transport system
Sa4125_34790	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Sa4125_34810	COG1706	bacterial-type flagellum-dependent cell motility
Sa4125_34830	COG4786	Flagellar basal body rod
Sa4125_34840	COG1677	Flagellar hook-basal body complex protein FliE
Sa4125_34850	COG1558	bacterial-type flagellum-dependent cell motility
Sa4125_34860	COG1815	bacterial-type flagellum-dependent cell motility
Sa4125_34870	COG0835	chemotaxis
Sa4125_34890	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Sa4125_34900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Sa4125_34910	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Sa4125_34940	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Sa4125_34950	COG4786	Flagellar basal body rod
Sa4125_34960	COG1157	protein secretion by the type III secretion system
Sa4125_34980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_34990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_35010	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Sa4125_35080	COG3328	transposase activity
Sa4125_35110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Sa4125_35120	COG1309	transcriptional regulator
Sa4125_35130	COG3300	MHYT domain
Sa4125_35130	COG5001	Diguanylate cyclase
Sa4125_35150	COG0493	'glutamate synthase
Sa4125_35230	COG0251	oxidation-reduction process
Sa4125_35240	COG0300	oxidoreductase activity
Sa4125_35260	COG1218	3'(2'),5'-bisphosphate nucleotidase
Sa4125_35270	COG1320	monovalent cation:proton antiporter activity
Sa4125_35280	COG2212	antiporter activity
Sa4125_35290	COG1863	multisubunit Na H antiporter MnhE subunit
Sa4125_35300	COG0651	ATP synthesis coupled electron transport
Sa4125_35310	COG1006	Multisubunit Na H antiporter MnhC subunit
Sa4125_35320	COG2111	Na H antiporter
Sa4125_35330	COG2111	Na H antiporter
Sa4125_35330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Sa4125_35350	COG2010	Cytochrome c
Sa4125_35370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Sa4125_35400	COG1376	ErfK ybiS ycfS ynhG family protein
Sa4125_35420	COG0433	COG0433 Predicted ATPase
Sa4125_35440	COG3920	Histidine kinase
Sa4125_35510	COG3415	Transposase
Sa4125_35520	COG3335	DDE superfamily endonuclease
Sa4125_35550	COG0535	radical SAM domain protein
Sa4125_35570	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
Sa4125_35580	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Sa4125_35590	COG1703	isobutyryl-CoA mutase activity
Sa4125_35690	COG1830	Aldolase
Sa4125_35710	COG3328	transposase activity
Sa4125_35760	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Sa4125_35770	COG3657	addiction module killer protein
Sa4125_35790	COG0446	pyridine nucleotide-disulphide oxidoreductase
Sa4125_35790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Sa4125_35810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa4125_35890	COG0693	protein deglycase activity
Sa4125_35920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Sa4125_35970	COG0583	DNA-binding transcription factor activity
Sa4125_35990	COG3153	acetyltransferase
Sa4125_36010	COG0523	cobalamin synthesis protein
Sa4125_36040	COG1609	Transcriptional regulator
Sa4125_36050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Sa4125_36090	COG0800	Aldolase
Sa4125_36100	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Sa4125_36140	COG3119	arylsulfatase activity
Sa4125_36150	COG3328	transposase activity
Sa4125_36170	COG0318	PFAM AMP-dependent synthetase and ligase
Sa4125_36200	COG0583	DNA-binding transcription factor activity
Sa4125_36230	COG0667	Aldo Keto reductase
Sa4125_36260	COG1376	ErfK ybiS ycfS ynhG family protein
Sa4125_36270	COG2081	HI0933 family
Sa4125_36280	COG0531	amino acid
Sa4125_36290	COG0542	response to heat
Sa4125_36310	COG2890	protein-(glutamine-N5) methyltransferase activity
Sa4125_36330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Sa4125_36350	COG0527	aspartate kinase activity
Sa4125_36360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Sa4125_36440	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Sa4125_36460	COG1040	competence protein
Sa4125_36470	COG2226	methyltransferase
Sa4125_36490	COG0494	nUDIX hydrolase
Sa4125_36510	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Sa4125_36520	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Sa4125_36530	COG0653	protein targeting
Sa4125_36540	COG3034	peptidoglycan biosynthetic process
Sa4125_36550	COG0825	malonyl-CoA metabolic process
Sa4125_36560	COG4974	Belongs to the 'phage' integrase family
Sa4125_36590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Sa4125_36660	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Sa4125_36670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Sa4125_36690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Sa4125_36700	COG0697	spore germination
Sa4125_36720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sa4125_36740	COG0667	Aldo Keto reductase
Sa4125_36750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Sa4125_36760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Sa4125_36780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Sa4125_36790	COG0287	Prephenate dehydrogenase
Sa4125_36850	COG2884	Cell division ATP-binding protein ftsE
Sa4125_36890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Sa4125_36900	COG0165	Argininosuccinate lyase
Sa4125_36920	COG0019	diaminopimelate decarboxylase activity
Sa4125_36940	COG4106	trans-aconitate 2-methyltransferase activity
Sa4125_36950	COG1250	3-hydroxyacyl-CoA dehydrogenase
Sa4125_36960	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Sa4125_36970	COG2086	electron transfer activity
Sa4125_36990	COG1511	domain protein
Sa4125_36990	COG3264	Mechanosensitive ion channel
Sa4125_37000	COG2096	Adenosyltransferase
Sa4125_37040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Sa4125_37120	COG0523	cobalamin synthesis protein
Sa4125_37130	COG1686	Belongs to the peptidase S11 family
Sa4125_37140	COG1473	amidohydrolase
Sa4125_37210	COG0673	inositol 2-dehydrogenase activity
Sa4125_37250	COG1175	transmembrane transport
Sa4125_37280	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Sa4125_37290	COG2971	BadF BadG BcrA BcrD
Sa4125_37300	COG2188	Transcriptional regulator
Sa4125_37310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Sa4125_37320	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Sa4125_37330	COG3842	ATPase activity
Sa4125_37360	COG0643	Histidine kinase
Sa4125_37360	COG2198	Histidine kinase
Sa4125_37380	COG0745	RESPONSE REGULATOR receiver
Sa4125_37390	COG0745	RESPONSE REGULATOR receiver
Sa4125_37420	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Sa4125_37430	COG1120	ATPase activity
Sa4125_37440	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sa4125_37450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Sa4125_37460	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Sa4125_37480	COG3034	peptidoglycan biosynthetic process
Sa4125_37590	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Sa4125_37600	COG0431	NADPH-dependent FMN reductase
Sa4125_37690	COG3012	SEC-C Motif Domain Protein
Sa4125_37690	COG3318	Belongs to the UPF0149 family
Sa4125_37720	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Sa4125_37750	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_37760	COG0183	Belongs to the thiolase family
Sa4125_37780	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Sa4125_37790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Sa4125_37800	COG0142	geranyltranstransferase activity
Sa4125_37830	COG3293	Transposase
Sa4125_37850	COG0739	heme binding
Sa4125_37850	COG0741	lytic transglycosylase activity
Sa4125_37850	COG1196	nuclear chromosome segregation
Sa4125_37890	COG1349	DNA-binding transcription factor activity
Sa4125_37900	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Sa4125_37930	COG0673	inositol 2-dehydrogenase activity
Sa4125_37960	COG1640	4-alpha-glucanotransferase
Sa4125_37970	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Sa4125_38000	COG2307	Protein conserved in bacteria
Sa4125_38000	COG2308	Evidence 4 Homologs of previously reported genes of
Sa4125_38020	COG3706	GGDEF domain
Sa4125_38050	COG0366	Alpha amylase catalytic
Sa4125_38060	COG0179	Fumarylacetoacetate (FAA) hydrolase
Sa4125_38080	COG0402	S-adenosylhomocysteine deaminase activity
Sa4125_38110	COG1079	Belongs to the binding-protein-dependent transport system permease family
Sa4125_38120	COG4603	Belongs to the binding-protein-dependent transport system permease family
Sa4125_38130	COG3845	ABC transporter
Sa4125_38150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Sa4125_38170	COG2351	hydroxyisourate hydrolase activity
Sa4125_38210	COG4266	Belongs to the allantoicase family
Sa4125_38220	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
Sa4125_38250	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Sa4125_38260	COG0830	nickel cation binding
Sa4125_38270	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Sa4125_38310	COG0804	urea catabolic process
Sa4125_38340	COG0832	Belongs to the urease beta subunit family
Sa4125_38370	COG0831	urea catabolic process
Sa4125_38400	COG1137	ATPase activity
Sa4125_38420	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sa4125_38460	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
Sa4125_38470	COG1229	Formylmethanofuran dehydrogenase subunit A
Sa4125_38480	COG1029	Formylmethanofuran dehydrogenase, subunit B
Sa4125_38490	COG2154	pterin-4-alpha-carbinolamine dehydratase
Sa4125_38510	COG0702	epimerase
Sa4125_38540	COG0189	ligase activity
Sa4125_38540	COG4067	protein conserved in archaea
Sa4125_38560	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
Sa4125_38570	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Sa4125_38640	COG0683	leucine binding
Sa4125_38660	COG2197	response regulator
Sa4125_38820	COG0405	Gamma-glutamyltransferase
Sa4125_38830	COG1454	alcohol dehydrogenase
Sa4125_38840	COG4948	Mandelate Racemase Muconate Lactonizing
Sa4125_38850	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Sa4125_38910	COG3328	transposase activity
Sa4125_38930	COG4957	zinc ion binding
Sa4125_39170	COG2963	transposase activity
Sa4125_39180	COG3436	PFAM IS66 Orf2 family protein
Sa4125_39190	COG2433	Pfam Transposase IS66
Sa4125_39220	COG4191	Histidine kinase
Sa4125_39240	COG4566	intracellular signal transduction
Sa4125_39270	COG2954	triphosphatase activity
Sa4125_39320	COG0443	Heat shock 70 kDa protein
Sa4125_39360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Sa4125_39360	COG1648	precorrin-2 dehydrogenase activity
Sa4125_39370	COG1072	(Pantothenic acid kinase))
Sa4125_39390	COG0438	transferase activity, transferring glycosyl groups
Sa4125_39400	COG0477	Major facilitator Superfamily
Sa4125_39440	COG0488	(ABC) transporter
Sa4125_39470	COG0848	biopolymer transport protein
Sa4125_39490	COG0179	Fumarylacetoacetate (FAA) hydrolase
Sa4125_39500	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_39510	COG3300	MHYT domain
Sa4125_39510	COG5001	Diguanylate cyclase
Sa4125_39520	COG0235	Class ii aldolase
Sa4125_39530	COG1609	Transcriptional regulator
Sa4125_39540	COG2084	Dehydrogenase
Sa4125_39550	COG3622	Belongs to the hyi family
Sa4125_39560	COG3395	kinase activity
Sa4125_39570	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_39580	COG3842	ATPase activity
Sa4125_39600	COG1175	transmembrane transport
Sa4125_39610	COG0395	ABC-type sugar transport system, permease component
Sa4125_39660	COG4172	Belongs to the ABC transporter superfamily
Sa4125_39680	COG0747	negative chemotaxis
Sa4125_39700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_39770	COG4251	negative regulation of phosphorylation
Sa4125_39780	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Sa4125_39800	COG0402	S-adenosylhomocysteine deaminase activity
Sa4125_39830	COG0577	efflux transmembrane transporter activity
Sa4125_39840	COG1136	(ABC) transporter
Sa4125_39850	COG2183	response to ionizing radiation
Sa4125_39860	COG0656	L-ascorbic acid biosynthetic process
Sa4125_39950	COG0297	glycogen (starch) synthase activity
Sa4125_40020	COG0456	acetyltransferase
Sa4125_40020	COG0454	-acetyltransferase
Sa4125_40070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Sa4125_40090	COG0402	S-adenosylhomocysteine deaminase activity
Sa4125_40110	COG4608	Belongs to the ABC transporter superfamily
Sa4125_40130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_40150	COG0747	negative chemotaxis
Sa4125_40170	COG2186	Transcriptional regulator
Sa4125_40180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Sa4125_40210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_40250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Sa4125_40270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Sa4125_40280	COG1609	Transcriptional regulator
Sa4125_40310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_40320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Sa4125_40340	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Sa4125_40350	COG1024	Enoyl-CoA hydratase
Sa4125_40400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Sa4125_40410	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Sa4125_40480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Sa4125_40510	COG1802	Transcriptional regulator
Sa4125_40560	COG0318	PFAM AMP-dependent synthetase and ligase
Sa4125_40590	COG3328	transposase activity
Sa4125_40600	COG2201	protein-glutamate methylesterase activity
Sa4125_40690	COG1846	Transcriptional regulator
Sa4125_40740	COG2080	2 iron, 2 sulfur cluster binding
Sa4125_40750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Sa4125_40750	COG2010	Cytochrome c
Sa4125_40790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Sa4125_40820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Sa4125_40860	COG3328	transposase activity
Sa4125_40920	COG1414	Transcriptional regulator
Sa4125_41000	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_41020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_41050	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_41060	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_41070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Sa4125_41120	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_41150	COG0601	transmembrane transport
Sa4125_41160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Sa4125_41190	COG1280	lysine exporter protein (LysE YggA)
Sa4125_41210	COG1414	Transcriptional regulator
Sa4125_41240	COG3842	ATPase activity
Sa4125_41250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Sa4125_41280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Sa4125_41300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Sa4125_41310	COG2358	TRAP transporter, solute receptor (TAXI family
Sa4125_41330	COG3328	transposase activity
Sa4125_41350	COG3328	transposase activity
Sa4125_41370	COG2801	Transposase and inactivated derivatives
Sa4125_41410	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Sa4125_41440	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Sa4125_41450	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Sa4125_41460	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Sa4125_41470	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Sa4125_41480	COG0799	negative regulation of ribosome biogenesis
Sa4125_41490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Sa4125_41510	COG0793	Belongs to the peptidase S41A family
Sa4125_41550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Sa4125_41570	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Sa4125_41580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Sa4125_41590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Sa4125_41600	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Sa4125_41650	COG1252	NADH dehydrogenase
Sa4125_41670	COG0783	Belongs to the Dps family
Sa4125_41710	COG3328	transposase activity
Sa4125_41720	COG3706	GGDEF domain
Sa4125_41760	COG1053	succinate dehydrogenase
Sa4125_41770	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Sa4125_41780	COG2009	succinate dehydrogenase
Sa4125_41800	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Sa4125_41810	COG3546	catalase activity
Sa4125_41820	COG0335	large ribosomal subunit rRNA binding
Sa4125_41840	COG0336	Belongs to the RNA methyltransferase TrmD family
Sa4125_41850	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Sa4125_41880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Sa4125_41910	COG0840	transmembrane signaling receptor activity
Sa4125_41920	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Sa4125_41930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sa4125_41940	COG0552	protein localization to endoplasmic reticulum
Sa4125_41970	COG2917	probably involved in intracellular septation
Sa4125_42020	COG3609	addiction module antidote protein, CC2985 family
Sa4125_42030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Sa4125_42050	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Sa4125_42060	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Sa4125_42070	COG4133	protoheme IX ABC transporter activity
Sa4125_42090	COG2910	NAD(P)H-binding
Sa4125_42100	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Sa4125_42140	COG0670	Belongs to the BI1 family
Sa4125_42150	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Sa4125_42160	COG4181	ATPase activity
Sa4125_42180	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Sa4125_42210	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Sa4125_42270	COG0137	argininosuccinate synthase activity
Sa4125_42280	COG3177	Filamentation induced by cAMP protein fic
Sa4125_42300	COG1620	l-lactate permease
Sa4125_42310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Sa4125_42320	COG0745	RESPONSE REGULATOR receiver
Sa4125_42340	COG0243	molybdopterin cofactor binding
Sa4125_42400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Sa4125_42410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Sa4125_42420	COG0181	hydroxymethylbilane synthase activity
Sa4125_42480	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Sa4125_42490	COG5001	Diguanylate cyclase
Sa4125_42490	COG3300	MHYT domain
Sa4125_42540	COG1872	DUF167
Sa4125_42550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Sa4125_42560	COG1760	l-serine dehydratase
Sa4125_42650	COG1217	gtp-binding protein TYPA
Sa4125_42660	COG0339	signal peptide processing
Sa4125_42710	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Sa4125_42720	COG1674	ftsk spoiiie
Sa4125_42740	COG0004	ammonium transporteR
Sa4125_42750	COG0347	Belongs to the P(II) protein family
Sa4125_42760	COG1946	Acyl-CoA thioesterase
Sa4125_42770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Sa4125_42790	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Sa4125_42810	COG0175	sulfate reduction
Sa4125_42820	COG0175	sulfate reduction
Sa4125_42860	COG2885	chlorophyll binding
Sa4125_42880	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Sa4125_42930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Sa4125_42940	COG0066	3-isopropylmalate dehydratase activity
Sa4125_42950	COG0318	PFAM AMP-dependent synthetase and ligase
Sa4125_42990	COG3328	transposase activity
Sa4125_43030	COG3706	GGDEF domain
Sa4125_43040	COG3706	GGDEF domain
Sa4125_43050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Sa4125_43070	COG0559	Belongs to the binding-protein-dependent transport system permease family
Sa4125_43100	COG0683	leucine binding
Sa4125_43130	COG2835	tetraacyldisaccharide 4'-kinase activity
Sa4125_43180	COG3046	protein related to deoxyribodipyrimidine photolyase
Sa4125_43230	COG0346	lactoylglutathione lyase activity
Sa4125_43240	COG0400	carboxylic ester hydrolase activity
Sa4125_43260	COG0587	DNA-directed DNA polymerase activity
Sa4125_43320	COG3328	transposase activity
Sa4125_43350	COG1764	response to oxidative stress
Sa4125_43410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Sa4125_43430	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_43460	COG0508	dehydrogenase complex catalyzes the overall conversion of
Sa4125_43480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Sa4125_43510	COG0045	succinate-CoA ligase (ADP-forming) activity
Sa4125_43520	COG0039	L-malate dehydrogenase activity
Sa4125_43530	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Sa4125_43550	COG0288	reversible hydration of carbon dioxide
Sa4125_43570	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Sa4125_43590	COG1704	LemA family
Sa4125_43600	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
Sa4125_43620	COG2902	Dehydrogenase
Sa4125_43660	COG0138	bifunctional purine biosynthesis protein purh
Sa4125_43700	COG0501	Belongs to the peptidase M48B family
Sa4125_43760	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Sa4125_43800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Sa4125_43880	COG0357	Ribosomal RNA small subunit methyltransferase G
Sa4125_43900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Sa4125_43910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Sa4125_43920	COG4993	Dehydrogenase
Sa4125_43930	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Sa4125_43940	COG3030	protein affecting phage T7 exclusion by the F plasmid
Sa4125_44000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Sa4125_44010	COG0237	dephospho-CoA kinase activity
Sa4125_44030	COG0424	maF-like protein
Sa4125_44040	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Sa4125_44050	COG1981	membrane
Sa4125_44100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Sa4125_44110	COG2197	response regulator
Sa4125_44120	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Sa4125_44140	COG0140	phosphoribosyl-ATP diphosphatase activity
Sa4125_44190	COG0539	negative regulation of cytoplasmic translation
Sa4125_44210	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Sa4125_44260	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Sa4125_44270	COG0131	Imidazoleglycerol-phosphate dehydratase
Sa4125_44290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Sa4125_44300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Sa4125_44380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Sa4125_44390	COG2203	Gaf domain
Sa4125_44390	COG3706	GGDEF domain
Sa4125_44390	COG4251	negative regulation of phosphorylation
Sa4125_44390	COG5001	Diguanylate cyclase
Sa4125_44420	COG1968	undecaprenyl-diphosphatase activity
Sa4125_44460	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Sa4125_44490	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Sa4125_44540	COG0534	Mate efflux family protein
Sa4125_44610	COG1879	ABC-type sugar transport system periplasmic component
Sa4125_44620	COG1129	ABC transporter
Sa4125_44640	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_44660	COG2721	sulfolactate sulfo-lyase activity
Sa4125_44680	COG1162	GTPase activity
Sa4125_44700	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Sa4125_44730	COG0133	tryptophan synthase activity
Sa4125_44810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Sa4125_44810	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Sa4125_44830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Sa4125_44850	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Sa4125_44860	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
Sa4125_44880	COG1309	transcriptional regulator
Sa4125_44890	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_44910	COG4221	oxidoreductase activity
Sa4125_44920	COG0583	DNA-binding transcription factor activity
Sa4125_44930	COG1643	Atp-dependent helicase
Sa4125_44940	COG4136	ATPase activity
Sa4125_44950	COG4135	transport system, permease component
Sa4125_44980	COG4134	Bacterial extracellular solute-binding protein
Sa4125_44990	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_45030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Sa4125_45050	COG0484	heat shock protein binding
Sa4125_45060	COG0443	Heat shock 70 kDa protein
Sa4125_45090	COG1376	ErfK ybiS ycfS ynhG family protein
Sa4125_45130	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Sa4125_45280	COG2894	cell division
Sa4125_45290	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Sa4125_45400	COG3608	succinylglutamate desuccinylase aspartoacylase
Sa4125_45410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Sa4125_45420	COG3328	transposase activity
Sa4125_45520	COG1312	Catalyzes the dehydration of D-mannonate
Sa4125_45530	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Sa4125_45540	COG0625	glutathione transferase activity
Sa4125_45570	COG3273	potassium ion transport
Sa4125_45570	COG0471	metal ion transport
Sa4125_45590	COG3300	MHYT domain
Sa4125_45590	COG5001	Diguanylate cyclase
Sa4125_45600	COG0667	Aldo Keto reductase
Sa4125_45610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Sa4125_45630	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_45640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Sa4125_45660	COG1074	ATP-dependent DNA helicase activity
Sa4125_45670	COG2887	Belongs to the helicase family. UvrD subfamily
Sa4125_45680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Sa4125_45690	COG3178	'Phosphotransferase
Sa4125_45700	COG2205	protein histidine kinase activity
Sa4125_45710	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Sa4125_45730	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sa4125_45740	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sa4125_45740	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Sa4125_45760	COG2205	protein histidine kinase activity
Sa4125_45770	COG0745	RESPONSE REGULATOR receiver
Sa4125_45780	COG3871	stress protein (general stress protein 26)
Sa4125_45790	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Sa4125_45810	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Sa4125_45820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Sa4125_45830	COG0071	Belongs to the small heat shock protein (HSP20) family
Sa4125_45850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Sa4125_45860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Sa4125_45870	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Sa4125_45880	COG1137	ATPase activity
Sa4125_45910	COG0616	signal peptide processing
Sa4125_45950	COG0116	Belongs to the methyltransferase superfamily
Sa4125_45950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Sa4125_45980	COG0604	alcohol dehydrogenase
Sa4125_46010	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Sa4125_46040	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Sa4125_46070	COG0180	Tryptophanyl-tRNA synthetase
Sa4125_46110	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Sa4125_46120	COG1214	PFAM Peptidase M22, glycoprotease
Sa4125_46150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Sa4125_46160	COG1702	phosphate starvation-inducible protein PhoH
Sa4125_46170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Sa4125_46180	COG1253	flavin adenine dinucleotide binding
Sa4125_46200	COG1396	sequence-specific DNA binding
Sa4125_46210	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Sa4125_46220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Sa4125_46230	COG0779	Required for maturation of 30S ribosomal subunits
Sa4125_46260	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Sa4125_46270	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Sa4125_46290	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Sa4125_46300	COG0583	DNA-binding transcription factor activity
Sa4125_46320	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Sa4125_46330	COG1185	polyribonucleotide nucleotidyltransferase activity
Sa4125_46360	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Sa4125_46380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Sa4125_46400	COG0735	belongs to the Fur family
Sa4125_46460	COG1129	ABC transporter
Sa4125_46470	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_46480	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_46490	COG3842	ATPase activity
Sa4125_46530	COG1175	transmembrane transport
Sa4125_46570	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_46580	COG1802	Transcriptional regulator
Sa4125_46600	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Sa4125_46610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Sa4125_46640	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_46650	COG1172	Belongs to the binding-protein-dependent transport system permease family
Sa4125_46660	COG1129	ABC transporter
Sa4125_46730	COG0511	ligase activity, forming carbon-carbon bonds
Sa4125_46730	COG5016	pyruvate
Sa4125_46740	COG0439	Biotin carboxylase
Sa4125_46760	COG1984	allophanate hydrolase subunit 2
Sa4125_46820	COG0756	dUTP diphosphatase activity
Sa4125_46830	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Sa4125_46860	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Sa4125_46870	COG2226	methyltransferase
Sa4125_46880	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Sa4125_46890	COG1024	Enoyl-CoA hydratase
Sa4125_46900	COG0268	Binds directly to 16S ribosomal RNA
Sa4125_46970	COG1960	acyl-CoA dehydrogenase activity
Sa4125_47020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Sa4125_47030	COG1012	belongs to the aldehyde dehydrogenase family
Sa4125_47040	COG2086	electron transfer activity
Sa4125_47050	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Sa4125_47060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Sa4125_47070	COG1126	abc transporter atp-binding protein
Sa4125_47080	COG0765	amino acid transport
Sa4125_47090	COG0765	amino acid transport
Sa4125_47100	COG2721	sulfolactate sulfo-lyase activity
Sa4125_47170	COG4770	biotin carboxylase activity
Sa4125_47180	COG3842	ATPase activity
Sa4125_47220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Sa4125_47230	COG1177	transmembrane transport
Sa4125_47260	COG2030	dehydratase
Sa4125_47270	COG1028	Short-chain dehydrogenase reductase Sdr
Sa4125_47290	COG3505	Type IV secretory pathway VirD4
Sa4125_47360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Sa4125_47450	COG3701	Conjugal transfer protein
Sa4125_47460	COG3846	protein secretion by the type IV secretion system
Sa4125_47480	COG5314	conjugation
Sa4125_47490	COG3451	type IV secretory pathway VirB4
Sa4125_47500	COG5268	conjugation
Sa4125_47520	COG4962	Type ii secretion system protein e
Sa4125_47530	COG3916	Acyl-homoserine-lactone synthase
Sa4125_47540	COG1192	Involved in chromosome partitioning
Sa4125_47550	COG1475	DNA binding
Sa4125_47560	COG1414	Transcriptional regulator
Sa4125_47610	COG3328	transposase activity
Sa4125_47670	COG2944	sequence-specific DNA binding
Sa4125_47690	COG1475	DNA binding
Sa4125_47730	COG4644	lycopene metabolic process
Sa4125_47740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
Sa4125_47780	COG3657	addiction module killer protein
Sa4125_47870	COG3706	GGDEF domain
Sa4125_47870	COG2203	Gaf domain
Sa4125_47870	COG5001	Diguanylate cyclase
Sa4125_47870	COG4251	negative regulation of phosphorylation
Sa4125_47880	COG5001	Diguanylate cyclase
Sa4125_47910	COG5001	Diguanylate cyclase
Sa4125_47920	COG2963	transposase activity
Sa4125_47930	COG3436	PFAM IS66 Orf2 family protein
Sa4125_47940	COG2433	Pfam Transposase IS66
Sa4125_47960	COG3415	Transposase
Sa4125_47970	COG3335	DDE superfamily endonuclease
Sa4125_47990	COG0840	transmembrane signaling receptor activity
Sa4125_48080	COG5489	Protein of unknown function (DUF736)
Sa4125_48100	COG3831	ATPase activity
Sa4125_48120	COG0583	DNA-binding transcription factor activity
Sa4125_48190	COG3293	Transposase
Sa4125_48210	COG1404	Belongs to the peptidase S8 family
Sa4125_48230	COG0464	growth