locus-tag	class	description
IPK37_00020	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IPK37_00025	COG2094	Belongs to the DNA glycosylase MPG family
IPK37_00030	COG0165	Argininosuccinate lyase
IPK37_00035	COG1438	arginine binding
IPK37_00040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IPK37_00045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IPK37_00050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IPK37_00055	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IPK37_00065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IPK37_00070	COG1028	Short-chain dehydrogenase reductase Sdr
IPK37_00075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPK37_00075	COG0072	phenylalanine-tRNA ligase activity
IPK37_00080	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IPK37_00090	COG5002	protein histidine kinase activity
IPK37_00100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IPK37_00105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IPK37_00110	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IPK37_00125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IPK37_00130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IPK37_00140	COG0131	Imidazoleglycerol-phosphate dehydratase
IPK37_00145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IPK37_00150	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IPK37_00170	COG2720	vancomycin resistance protein
IPK37_00230	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IPK37_00250	COG1799	cell septum assembly
IPK37_00260	COG1496	oxidoreductase activity
IPK37_00265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IPK37_00270	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IPK37_00275	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IPK37_00290	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IPK37_00295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IPK37_00300	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IPK37_00305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IPK37_00310	COG0768	penicillin binding
IPK37_00320	COG0275	rRNA processing
IPK37_00325	COG2001	Belongs to the MraZ family
IPK37_00330	COG0714	Associated with various cellular activities
IPK37_00340	COG1305	Transglutaminase-like
IPK37_00355	COG0799	negative regulation of ribosome biogenesis
IPK37_00360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IPK37_00370	COG0463	Glycosyl transferase, family 2
IPK37_00375	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IPK37_00380	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IPK37_00390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IPK37_00400	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IPK37_00405	COG1530	ribonuclease E activity
IPK37_00415	COG1136	(ABC) transporter
IPK37_00465	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IPK37_00470	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IPK37_00475	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IPK37_00475	COG0481	GTPase activity
IPK37_00490	COG0779	Required for maturation of 30S ribosomal subunits
IPK37_00520	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IPK37_00545	COG1331	Highly conserved protein containing a thioredoxin domain
IPK37_00575	COG0778	Nitroreductase
IPK37_00590	COG0402	S-adenosylhomocysteine deaminase activity
IPK37_00595	COG1984	allophanate hydrolase subunit 2
IPK37_00600	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IPK37_00605	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IPK37_00615	COG0583	DNA-binding transcription factor activity
IPK37_00630	COG0442	prolyl-tRNA aminoacylation
IPK37_00660	COG0477	Major facilitator Superfamily
IPK37_00670	COG0477	Major facilitator Superfamily
IPK37_00680	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IPK37_00685	COG0750	zinc metalloprotease
IPK37_00690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IPK37_00740	COG0277	FAD linked oxidase domain protein
IPK37_00755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IPK37_00765	COG0575	Belongs to the CDS family
IPK37_00770	COG0233	cytoplasmic translational termination
IPK37_00775	COG0528	UMP kinase activity
IPK37_00780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IPK37_00785	COG0052	Belongs to the universal ribosomal protein uS2 family
IPK37_00805	COG4974	Belongs to the 'phage' integrase family
IPK37_00820	COG0792	nuclease activity
IPK37_00835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IPK37_00840	COG0681	Belongs to the peptidase S26 family
IPK37_00845	COG0681	Belongs to the peptidase S26 family
IPK37_00850	COG0335	large ribosomal subunit rRNA binding
IPK37_00855	COG0336	Belongs to the RNA methyltransferase TrmD family
IPK37_00860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IPK37_00865	COG1837	Belongs to the UPF0109 family
IPK37_00870	COG0228	four-way junction DNA binding
IPK37_00895	COG0840	transmembrane signaling receptor activity
IPK37_00915	COG3033	Beta-eliminating lyase
IPK37_00925	COG0840	transmembrane signaling receptor activity
IPK37_00945	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
IPK37_00970	COG4214	carbohydrate transport
IPK37_01000	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IPK37_01030	COG1196	nuclear chromosome segregation
IPK37_01065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPK37_01070	COG0571	ribonuclease III activity
IPK37_01075	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IPK37_01085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IPK37_01095	COG0742	ribosomal rna small subunit methyltransferase
IPK37_01100	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IPK37_01105	COG1461	Dihydroxyacetone kinase
IPK37_01110	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IPK37_01145	COG1181	Belongs to the D-alanine--D-alanine ligase family
IPK37_01150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IPK37_01160	COG1920	GTP binding
IPK37_01165	COG0776	regulation of translation
IPK37_01170	COG0066	3-isopropylmalate dehydratase activity
IPK37_01175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IPK37_01180	COG1414	Transcriptional regulator
IPK37_01195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPK37_01210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IPK37_01215	COG0179	Fumarylacetoacetate (FAA) hydrolase
IPK37_01220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IPK37_01240	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IPK37_01245	COG0473	3-isopropylmalate dehydrogenase activity
IPK37_01265	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
IPK37_01270	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IPK37_01275	COG0440	acetolactate synthase activity
IPK37_01305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPK37_01320	COG0154	amidase activity
IPK37_01325	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IPK37_01350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IPK37_01365	COG0367	asparagine synthase
IPK37_01380	COG2801	Transposase and inactivated derivatives
IPK37_01425	COG1335	isochorismatase
IPK37_01450	COG0482	sulfurtransferase activity
IPK37_01460	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IPK37_01470	COG0110	maltose O-acetyltransferase activity
IPK37_01475	COG1024	Enoyl-CoA hydratase
IPK37_01490	COG0058	SHG alpha-glucan phosphorylase activity
IPK37_01495	COG0366	Alpha amylase catalytic
IPK37_01500	COG0366	Alpha amylase catalytic
IPK37_01505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IPK37_01510	COG0579	oxidoreductase
IPK37_01520	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IPK37_01525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IPK37_01570	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPK37_01570	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPK37_01590	COG1136	(ABC) transporter
IPK37_01590	COG0577	efflux transmembrane transporter activity
IPK37_01615	COG0183	Belongs to the thiolase family
IPK37_01620	COG0346	lactoylglutathione lyase activity
IPK37_01630	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPK37_01635	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
IPK37_01645	COG0405	Gamma-glutamyltransferase
IPK37_01655	COG1215	transferase activity, transferring glycosyl groups
IPK37_01675	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPK37_01675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPK37_01690	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IPK37_01710	COG0110	maltose O-acetyltransferase activity
IPK37_01715	COG0438	transferase activity, transferring glycosyl groups
IPK37_01735	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
IPK37_01745	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IPK37_01750	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IPK37_01755	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IPK37_01760	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPK37_01765	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IPK37_01770	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IPK37_01775	COG0356	it plays a direct role in the translocation of protons across the membrane
IPK37_01795	COG1556	Lactate utilization protein
IPK37_01800	COG1139	Iron-sulfur cluster binding protein
IPK37_01805	COG0247	lactate metabolic process
IPK37_01810	COG1620	l-lactate permease
IPK37_01815	COG2186	Transcriptional regulator
IPK37_01820	COG0009	L-threonylcarbamoyladenylate synthase
IPK37_01830	COG2890	protein-(glutamine-N5) methyltransferase activity
IPK37_01835	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IPK37_01840	COG0254	rRNA binding
IPK37_01860	COG0745	RESPONSE REGULATOR receiver
IPK37_01875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IPK37_01880	COG0460	homoserine dehydrogenase
IPK37_01885	COG0019	diaminopimelate decarboxylase activity
IPK37_01890	COG0018	arginyl-trna synthetase
IPK37_01920	COG1253	flavin adenine dinucleotide binding
IPK37_01925	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPK37_01925	COG0567	Dehydrogenase, E1 component
IPK37_01955	COG1086	Polysaccharide biosynthesis protein
IPK37_01980	COG0840	transmembrane signaling receptor activity
IPK37_01990	COG2119	membrane
IPK37_02010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IPK37_02025	COG1316	TRANSCRIPTIONal
IPK37_02045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPK37_02070	COG0601	transmembrane transport
IPK37_02075	COG0747	negative chemotaxis
IPK37_02080	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IPK37_02095	COG0745	RESPONSE REGULATOR receiver
IPK37_02100	COG1024	Enoyl-CoA hydratase
IPK37_02115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPK37_02130	COG0424	maF-like protein
IPK37_02150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IPK37_02155	COG1960	acyl-CoA dehydrogenase activity
IPK37_02175	COG4770	biotin carboxylase activity
IPK37_02195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPK37_02220	COG0714	Associated with various cellular activities
IPK37_02260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPK37_02280	COG3311	Transcriptional regulator
IPK37_02290	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPK37_02290	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPK37_02310	COG1686	Belongs to the peptidase S11 family
IPK37_02370	COG0039	L-malate dehydrogenase activity
IPK37_02380	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IPK37_02405	COG0138	bifunctional purine biosynthesis protein purh
IPK37_02425	COG1595	DNA-templated transcription, initiation
IPK37_02465	COG1215	transferase activity, transferring glycosyl groups
IPK37_02470	COG0726	polysaccharide deacetylase
IPK37_02490	COG1215	transferase activity, transferring glycosyl groups
IPK37_02495	COG0726	polysaccharide deacetylase
IPK37_02500	COG1301	dicarboxylic acid transport
IPK37_02515	COG1301	dicarboxylic acid transport
IPK37_02525	COG0045	succinate-CoA ligase (ADP-forming) activity
IPK37_02535	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IPK37_02540	COG0739	heme binding
IPK37_02565	COG2197	response regulator
IPK37_02595	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPK37_02630	COG0535	radical SAM domain protein
IPK37_02655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPK37_02655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPK37_02675	COG0519	Catalyzes the synthesis of GMP from XMP
IPK37_02675	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IPK37_02695	COG1012	belongs to the aldehyde dehydrogenase family
IPK37_02700	COG0516	GMP reductase activity
IPK37_02720	COG1595	DNA-templated transcription, initiation
IPK37_02730	COG0459	protein refolding
IPK37_02735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IPK37_02745	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IPK37_02750	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IPK37_02755	COG4948	Mandelate Racemase Muconate Lactonizing
IPK37_02760	COG0857	belongs to the CobB CobQ family
IPK37_02760	COG0280	phosphate acetyltransferase
IPK37_02765	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IPK37_02795	COG1929	Belongs to the glycerate kinase type-1 family
IPK37_02800	COG0596	Alpha beta hydrolase
IPK37_02800	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPK37_02840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IPK37_02860	COG0785	Cytochrome C biogenesis protein
IPK37_02870	COG0406	alpha-ribazole phosphatase activity
IPK37_02875	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IPK37_02885	COG1846	Transcriptional regulator
IPK37_02890	COG0113	porphobilinogen synthase activity
IPK37_02900	COG0181	hydroxymethylbilane synthase activity
IPK37_02905	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IPK37_02910	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IPK37_02920	COG0366	Alpha amylase catalytic
IPK37_02930	COG0204	Acyl-transferase
IPK37_02950	COG0123	including yeast histone deacetylase and acetoin utilization protein
IPK37_02960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IPK37_02975	COG1131	(ABC) transporter
IPK37_02990	COG1082	Xylose isomerase domain protein TIM barrel
IPK37_03000	COG0248	Ppx GppA phosphatase
IPK37_03010	COG2226	methyltransferase
IPK37_03020	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IPK37_03025	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IPK37_03055	COG1131	(ABC) transporter
IPK37_03065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IPK37_03075	COG1121	(ABC) transporter
IPK37_03080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IPK37_03115	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IPK37_03120	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IPK37_03150	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IPK37_03155	COG1793	dna ligase
IPK37_03155	COG3285	dna ligase
IPK37_03195	COG0302	gtp cyclohydrolase
IPK37_03215	COG0037	tRNA processing
IPK37_03235	COG2027	D-alanyl-D-alanine carboxypeptidase
IPK37_03245	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IPK37_03260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IPK37_03265	COG0372	Belongs to the citrate synthase family
IPK37_03300	COG0477	Major facilitator Superfamily
IPK37_03350	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IPK37_03355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IPK37_03365	COG1754	DNA topoisomerase type I activity
IPK37_03365	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IPK37_03370	COG3384	dioxygenase
IPK37_03390	COG1366	Belongs to the anti-sigma-factor antagonist family
IPK37_03395	COG1205	dead DEAH box helicase
IPK37_03395	COG1111	helicase
IPK37_03435	COG3275	phosphorelay sensor kinase activity
IPK37_03450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IPK37_03465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPK37_03475	COG0205	6-phosphofructokinase activity
IPK37_03480	COG0584	glycerophosphoryl diester phosphodiesterase
IPK37_03490	COG2267	carboxylic ester hydrolase activity
IPK37_03540	COG0003	Pfam Anion-transporting ATPase
IPK37_03550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPK37_03555	COG1408	metallophosphoesterase
IPK37_03565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPK37_03565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPK37_03665	COG1414	Transcriptional regulator
IPK37_03670	COG0800	Aldolase
IPK37_03675	COG1396	sequence-specific DNA binding
IPK37_03690	COG0740	serine-type endopeptidase activity
IPK37_03695	COG0740	serine-type endopeptidase activity
IPK37_03725	COG2099	Precorrin-6x reductase
IPK37_03730	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IPK37_03735	COG0375	protein maturation
IPK37_03740	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IPK37_03745	COG0298	carbon dioxide binding
IPK37_03760	COG0298	carbon dioxide binding
IPK37_03775	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IPK37_03785	COG3383	formate dehydrogenase (NAD+) activity
IPK37_03790	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
IPK37_03795	COG3259	Nickel-dependent hydrogenase
IPK37_03805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IPK37_03805	COG1648	precorrin-2 dehydrogenase activity
IPK37_03810	COG1797	cobyrinic acid a,c-diamide synthase activity
IPK37_03830	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
IPK37_03835	COG0310	cobalt ion transport
IPK37_03850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IPK37_03850	COG1648	precorrin-2 dehydrogenase activity
IPK37_03875	COG1492	cobalamin metabolic process
IPK37_03880	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IPK37_03905	COG0129	dihydroxy-acid dehydratase activity
IPK37_03920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IPK37_03970	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IPK37_03975	COG0318	PFAM AMP-dependent synthetase and ligase
IPK37_03975	COG0204	Acyl-transferase
IPK37_03985	COG0745	RESPONSE REGULATOR receiver
IPK37_04020	COG0433	COG0433 Predicted ATPase
IPK37_04030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPK37_04045	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
IPK37_04050	COG3052	prosthetic group binding
IPK37_04075	COG3663	DNA glycosylase
IPK37_04120	COG0037	tRNA processing
IPK37_04120	COG0590	tRNA wobble adenosine to inosine editing
IPK37_04125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IPK37_04130	COG2197	response regulator
IPK37_04135	COG4585	Histidine kinase
IPK37_04145	COG1131	(ABC) transporter
IPK37_04175	COG1122	ATPase activity
IPK37_04190	COG0531	amino acid
IPK37_04195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IPK37_04350	COG1714	RDD family
IPK37_04360	COG1472	Belongs to the glycosyl hydrolase 3 family
IPK37_04375	COG0745	RESPONSE REGULATOR receiver
IPK37_04380	COG2205	protein histidine kinase activity
IPK37_04385	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IPK37_04400	COG1278	Cold shock
IPK37_04410	COG1937	Protein conserved in bacteria
IPK37_04450	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IPK37_04450	COG1672	PFAM Archaeal ATPase
IPK37_04460	COG1045	serine acetyltransferase
IPK37_04470	COG2181	nitrate reductase activity
IPK37_04470	COG0247	lactate metabolic process
IPK37_04480	COG0656	L-ascorbic acid biosynthetic process
IPK37_04520	COG3220	belongs to the UPF0276 family
IPK37_04535	COG1174	glycine betaine transport
IPK37_04540	COG1174	glycine betaine transport
IPK37_04550	COG0110	maltose O-acetyltransferase activity
IPK37_04560	COG0717	Belongs to the dCTP deaminase family
IPK37_04575	COG5002	protein histidine kinase activity
IPK37_04585	COG4251	negative regulation of phosphorylation
IPK37_04605	COG5607	PFAM CHAD domain containing protein
IPK37_04605	COG3025	triphosphatase activity
IPK37_04610	COG1960	acyl-CoA dehydrogenase activity
IPK37_04625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPK37_04650	COG3135	benzoate transporter
IPK37_04680	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPK37_04685	COG0022	dehydrogenase e1 component
IPK37_04700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IPK37_04720	COG1280	lysine exporter protein (LysE YggA)
IPK37_04735	COG0242	peptide deformylase activity
IPK37_04765	COG3033	Beta-eliminating lyase
IPK37_04775	COG0738	Major facilitator superfamily
IPK37_04810	COG0415	Belongs to the DNA photolyase family
IPK37_04815	COG4115	mRNA cleavage
IPK37_04820	COG2161	toxin-antitoxin pair type II binding
IPK37_04830	COG0842	Transport permease protein
IPK37_04835	COG1131	(ABC) transporter
IPK37_04865	COG3850	Histidine kinase
IPK37_04865	COG5002	protein histidine kinase activity
IPK37_04870	COG0745	RESPONSE REGULATOR receiver
IPK37_04875	COG0598	Magnesium transport protein CorA
IPK37_04925	COG0529	Catalyzes the synthesis of activated sulfate
IPK37_04930	COG0175	sulfate reduction
IPK37_04935	COG0730	response to heat
IPK37_04945	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IPK37_04945	COG1648	precorrin-2 dehydrogenase activity
IPK37_04950	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IPK37_05010	COG0351	phosphomethylpyrimidine kinase
IPK37_05015	COG1132	(ABC) transporter
IPK37_05040	COG1028	Short-chain dehydrogenase reductase Sdr
IPK37_05070	COG3246	L-lysine catabolic process to acetate
IPK37_05080	COG5002	protein histidine kinase activity
IPK37_05085	COG3162	membrane
IPK37_05090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IPK37_05105	COG0488	(ABC) transporter
IPK37_05115	COG4260	virion core protein, lumpy skin disease virus
IPK37_05130	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IPK37_05135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IPK37_05145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPK37_05150	COG0183	Belongs to the thiolase family
IPK37_05175	COG0009	L-threonylcarbamoyladenylate synthase
IPK37_05235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IPK37_05240	COG1357	PFAM Pentapeptide repeats (8 copies)
IPK37_05285	COG3718	enzyme involved in inositol metabolism
IPK37_05295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPK37_05305	COG0673	inositol 2-dehydrogenase activity
IPK37_05315	COG1172	Belongs to the binding-protein-dependent transport system permease family
IPK37_05320	COG1129	ABC transporter
IPK37_05335	COG1082	Xylose isomerase domain protein TIM barrel
IPK37_05340	COG0673	inositol 2-dehydrogenase activity
IPK37_05350	COG2188	Transcriptional regulator
IPK37_05365	COG2133	pyrroloquinoline quinone binding
IPK37_05380	COG0657	acetylesterase activity
IPK37_05385	COG2814	Major facilitator Superfamily
IPK37_05460	COG0446	pyridine nucleotide-disulphide oxidoreductase
IPK37_05470	COG1105	Belongs to the carbohydrate kinase PfkB family
IPK37_05485	COG4191	Histidine kinase
IPK37_05505	COG1355	regulation of microtubule-based process
IPK37_05530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPK37_05560	COG3459	Glycosyltransferase 36 associated
IPK37_05565	COG0673	inositol 2-dehydrogenase activity
IPK37_05570	COG0318	PFAM AMP-dependent synthetase and ligase
IPK37_05600	COG4977	sequence-specific DNA binding
IPK37_05640	COG0697	spore germination
IPK37_05650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IPK37_05665	COG0596	Alpha beta hydrolase
IPK37_05680	COG0436	Aminotransferase
IPK37_05690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IPK37_05730	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IPK37_05735	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IPK37_05760	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IPK37_05770	COG0626	cystathionine gamma-synthase activity
IPK37_05795	COG4716	Myosin-crossreactive antigen
IPK37_05800	COG1309	transcriptional regulator
IPK37_05815	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
IPK37_05830	COG2032	superoxide dismutase activity
IPK37_05835	COG0765	amino acid transport
IPK37_05840	COG0765	amino acid transport
IPK37_05845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPK37_05850	COG1126	abc transporter atp-binding protein
IPK37_05855	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
IPK37_05870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPK37_05895	COG1191	sigma factor activity
IPK37_05935	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IPK37_05940	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IPK37_05945	COG1741	Belongs to the pirin family
IPK37_05950	COG2226	methyltransferase
IPK37_05965	COG2860	membrane
IPK37_05970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPK37_05980	COG2409	Drug exporters of the RND superfamily
IPK37_05995	COG1793	dna ligase
IPK37_06010	COG0628	permease
IPK37_06015	COG2814	Major facilitator Superfamily
IPK37_06035	COG0656	L-ascorbic acid biosynthetic process
IPK37_06045	COG1166	arginine decarboxylase activity
IPK37_06055	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IPK37_06070	COG0583	DNA-binding transcription factor activity
IPK37_06080	COG2186	Transcriptional regulator
IPK37_06095	COG4948	Mandelate Racemase Muconate Lactonizing
IPK37_06100	COG2084	Dehydrogenase
IPK37_06110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IPK37_06120	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IPK37_06135	COG0318	PFAM AMP-dependent synthetase and ligase
IPK37_06140	COG3158	transport of potassium into the cell
IPK37_06195	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IPK37_06205	COG2197	response regulator
IPK37_06210	COG1022	Amp-dependent synthetase and ligase
IPK37_06225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IPK37_06270	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IPK37_06270	COG2308	Evidence 4 Homologs of previously reported genes of
IPK37_06275	COG1902	pentaerythritol trinitrate reductase activity
IPK37_06275	COG0446	pyridine nucleotide-disulphide oxidoreductase
IPK37_06280	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IPK37_06285	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IPK37_06290	COG3383	formate dehydrogenase (NAD+) activity
IPK37_06295	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
IPK37_06300	COG3259	Nickel-dependent hydrogenase
IPK37_06310	COG4942	peptidase
IPK37_06345	COG1793	dna ligase
IPK37_06345	COG3285	dna ligase
IPK37_06360	COG5002	protein histidine kinase activity
IPK37_06365	COG0745	RESPONSE REGULATOR receiver
IPK37_06385	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IPK37_06400	COG3268	Saccharopine dehydrogenase
IPK37_06445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IPK37_06450	COG0798	PFAM Bile acid sodium symporter
IPK37_06490	COG0456	acetyltransferase
IPK37_06495	COG2610	gluconate transmembrane transporter activity
IPK37_06505	COG1028	Short-chain dehydrogenase reductase Sdr
IPK37_06510	COG3548	integral membrane protein
IPK37_06515	COG0662	Cupin 2, conserved barrel domain protein
IPK37_06520	COG2318	DinB family
IPK37_06530	COG0730	response to heat
IPK37_06535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPK37_06550	COG0348	domain, Protein
IPK37_06565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPK37_06570	COG1054	Belongs to the UPF0176 family
IPK37_06590	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
IPK37_06615	COG3655	Transcriptional regulator
IPK37_06650	COG0640	Transcriptional regulator
IPK37_06675	COG2197	response regulator
IPK37_06680	COG4585	Histidine kinase
IPK37_06695	COG1733	regulation of RNA biosynthetic process
IPK37_06700	COG2161	toxin-antitoxin pair type II binding
IPK37_06705	COG2026	Addiction module toxin, RelE StbE family
IPK37_06740	COG1201	RNA secondary structure unwinding
IPK37_06780	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IPK37_06790	COG0438	transferase activity, transferring glycosyl groups
IPK37_06870	COG1487	ribonuclease activity
IPK37_06900	COG3547	Transposase (IS116 IS110 IS902 family)
IPK37_06955	COG0359	binds to the 23S rRNA
IPK37_06960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IPK37_06970	COG0360	Binds together with S18 to 16S ribosomal RNA
IPK37_06980	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IPK37_06995	COG1309	transcriptional regulator
IPK37_07000	COG1131	(ABC) transporter
IPK37_07020	COG2318	DinB family
IPK37_07025	COG0617	tRNA 3'-terminal CCA addition
IPK37_07040	COG0728	peptidoglycan biosynthetic process
IPK37_07050	COG1595	DNA-templated transcription, initiation
IPK37_07060	COG0492	ferredoxin-NADP+ reductase activity
IPK37_07065	COG3118	belongs to the thioredoxin family
IPK37_07085	COG1192	Involved in chromosome partitioning
IPK37_07100	COG0357	Ribosomal RNA small subunit methyltransferase G
IPK37_07110	COG0706	membrane insertase activity
IPK37_07120	COG0594	ribonuclease P activity
IPK37_07125	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IPK37_07130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IPK37_07135	COG0592	DNA-directed DNA polymerase activity
IPK37_07140	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IPK37_07145	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IPK37_07150	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IPK37_07155	COG0187	DNA topoisomerase II activity
IPK37_07160	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IPK37_07175	COG0387	Pfam Sodium calcium exchanger
IPK37_07260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IPK37_07275	COG3764	Sortase (surface protein transpeptidase)
IPK37_07290	COG0515	serine threonine protein kinase
IPK37_07295	COG0515	serine threonine protein kinase
IPK37_07300	COG0768	penicillin binding
IPK37_07315	COG1716	ATPase activity
IPK37_07425	COG0789	Transcriptional regulator
IPK37_07445	COG1473	amidohydrolase
IPK37_07450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IPK37_07460	COG0352	thiamine-phosphate diphosphorylase activity
IPK37_07465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IPK37_07470	COG2022	thiamine diphosphate biosynthetic process
IPK37_07500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IPK37_07615	COG0427	acetyl-CoA hydrolase
IPK37_07630	COG2818	Glycosylase
IPK37_07665	COG1131	(ABC) transporter
IPK37_07680	COG0676	glucose-6-phosphate 1-epimerase activity
IPK37_07690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IPK37_07700	COG1011	Hydrolase
IPK37_07705	COG0483	inositol monophosphate 1-phosphatase activity
IPK37_07755	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPK37_07760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IPK37_07765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IPK37_07830	COG0513	Belongs to the DEAD box helicase family
IPK37_07835	COG0628	permease
IPK37_07850	COG1028	Short-chain dehydrogenase reductase Sdr
IPK37_07855	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IPK37_07865	COG3958	Transketolase
IPK37_07870	COG3959	Transketolase, thiamine diphosphate binding domain
IPK37_07880	COG2409	Drug exporters of the RND superfamily
IPK37_07885	COG0789	Transcriptional regulator
IPK37_07915	COG2226	methyltransferase
IPK37_07920	COG1233	COG1233 Phytoene dehydrogenase and related
IPK37_07930	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
IPK37_07950	COG0702	epimerase
IPK37_07970	COG0515	serine threonine protein kinase
IPK37_07975	COG0842	Transport permease protein
IPK37_07975	COG1716	ATPase activity
IPK37_07975	COG1131	(ABC) transporter
IPK37_08015	COG2814	Major facilitator Superfamily
IPK37_08045	COG0657	acetylesterase activity
IPK37_08055	COG2814	Major facilitator Superfamily
IPK37_08070	COG0183	Belongs to the thiolase family
IPK37_08100	COG4977	sequence-specific DNA binding
IPK37_08120	COG3243	poly(R)-hydroxyalkanoic acid synthase
IPK37_08130	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
IPK37_08180	COG0657	acetylesterase activity
IPK37_08190	COG0706	membrane insertase activity
IPK37_08195	COG1486	melibiose metabolic process
IPK37_08200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IPK37_08220	COG0651	ATP synthesis coupled electron transport
IPK37_08225	COG1006	Multisubunit Na H antiporter MnhC subunit
IPK37_08230	COG2111	Na H antiporter
IPK37_08230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IPK37_08245	COG0531	amino acid
IPK37_08250	COG0363	glucosamine-6-phosphate deaminase activity
IPK37_08285	COG1140	nitrate reductase beta subunit
IPK37_08320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPK37_08350	COG0671	phosphoesterase, PA-phosphatase related
IPK37_08360	COG3973	AAA domain
IPK37_08375	COG0366	Alpha amylase catalytic
IPK37_08385	COG3328	transposase activity
IPK37_08405	COG0395	ABC-type sugar transport system, permease component
IPK37_08415	COG2226	methyltransferase
IPK37_08460	COG0428	transporter
IPK37_08470	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IPK37_08485	COG3340	Belongs to the peptidase S51 family
IPK37_08510	COG2267	carboxylic ester hydrolase activity
IPK37_08535	COG0693	protein deglycase activity
IPK37_08540	COG1136	(ABC) transporter
IPK37_08540	COG0577	efflux transmembrane transporter activity
IPK37_08545	COG0577	efflux transmembrane transporter activity
IPK37_08545	COG1136	(ABC) transporter
IPK37_08550	COG2197	response regulator
IPK37_08555	COG4585	Histidine kinase
IPK37_08575	COG1131	(ABC) transporter
IPK37_08580	COG2197	response regulator
IPK37_08605	COG1012	belongs to the aldehyde dehydrogenase family
IPK37_08625	COG0500	methyltransferase
IPK37_08640	COG1151	hydroxylamine reductase activity
IPK37_08670	COG0671	phosphoesterase, PA-phosphatase related
IPK37_08675	COG1597	lipid kinase activity
IPK37_08675	COG1803	Methylglyoxal synthase
IPK37_08680	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IPK37_08730	COG3265	gluconokinase activity
IPK37_08740	COG4585	Histidine kinase
IPK37_08745	COG2197	response regulator
IPK37_08755	COG4152	abc transporter atp-binding protein
IPK37_08765	COG0561	phosphatase activity
IPK37_08800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IPK37_08815	COG1132	(ABC) transporter
IPK37_08820	COG4988	ABC transporter
IPK37_08825	COG1294	oxidase, subunit
IPK37_08830	COG1271	oxidase subunit
IPK37_08835	COG2235	arginine
IPK37_08840	COG0500	methyltransferase
IPK37_08845	COG1716	ATPase activity
IPK37_08860	COG0515	serine threonine protein kinase
IPK37_08915	COG0517	IMP dehydrogenase activity
IPK37_08930	COG2197	response regulator
IPK37_08940	COG2409	Drug exporters of the RND superfamily
IPK37_08950	COG1362	aminopeptidase activity
IPK37_08960	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPK37_08960	COG0574	Belongs to the PEP-utilizing enzyme family
IPK37_08970	COG1950	PFAM Membrane protein of
IPK37_08980	COG1028	Short-chain dehydrogenase reductase Sdr
IPK37_08980	COG0604	alcohol dehydrogenase
IPK37_08980	COG3321	synthase
IPK37_09030	COG0463	Glycosyl transferase, family 2
IPK37_09045	COG3340	Belongs to the peptidase S51 family
IPK37_09055	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPK37_09070	COG1522	sequence-specific DNA binding
IPK37_09080	COG4721	ABC-type cobalt transport system, permease component
IPK37_09085	COG1122	ATPase activity
IPK37_09100	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IPK37_09150	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IPK37_09160	COG1309	transcriptional regulator
IPK37_09165	COG0477	Major facilitator Superfamily
IPK37_09175	COG0657	acetylesterase activity
IPK37_09180	COG2205	protein histidine kinase activity
IPK37_09185	COG2205	protein histidine kinase activity
IPK37_09205	COG1131	(ABC) transporter
IPK37_09220	COG0395	ABC-type sugar transport system, permease component
IPK37_09230	COG2182	Extracellular solute-binding protein
IPK37_09235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IPK37_09245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IPK37_09250	COG1349	DNA-binding transcription factor activity
IPK37_09290	COG0154	amidase activity
IPK37_09295	COG1028	Short-chain dehydrogenase reductase Sdr
IPK37_09300	COG2610	gluconate transmembrane transporter activity
IPK37_09320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IPK37_09365	COG1175	transmembrane transport
IPK37_09370	COG0395	ABC-type sugar transport system, permease component
IPK37_09375	COG1472	Belongs to the glycosyl hydrolase 3 family
IPK37_09380	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IPK37_09385	COG1737	Transcriptional regulator
IPK37_09415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IPK37_09420	COG3962	Belongs to the TPP enzyme family
IPK37_09425	COG0673	inositol 2-dehydrogenase activity
IPK37_09465	COG2801	Transposase and inactivated derivatives
IPK37_09480	COG0673	inositol 2-dehydrogenase activity
IPK37_09540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPK37_09545	COG0698	ribose 5-phosphate isomerase
IPK37_09575	COG0789	Transcriptional regulator
IPK37_09580	COG0667	Aldo Keto reductase
IPK37_09645	COG3162	membrane
IPK37_09650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IPK37_09660	COG1028	Short-chain dehydrogenase reductase Sdr
IPK37_09670	COG0183	Belongs to the thiolase family
IPK37_09675	COG0318	PFAM AMP-dependent synthetase and ligase
IPK37_09700	COG1309	transcriptional regulator
IPK37_09705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IPK37_09710	COG2151	metal-sulfur cluster biosynthetic enzyme
IPK37_09715	COG3396	Phenylacetate-CoA oxygenase
IPK37_09720	COG3460	Phenylacetate-CoA oxygenase
IPK37_09725	COG3396	Phenylacetate-CoA oxygenase
IPK37_09730	COG2030	dehydratase
IPK37_09730	COG1012	belongs to the aldehyde dehydrogenase family
IPK37_09735	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPK37_09750	COG0813	purine-nucleoside phosphorylase activity
IPK37_09775	COG0025	NhaP-type Na H and K H
IPK37_09780	COG1136	(ABC) transporter
IPK37_09810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IPK37_09815	COG1333	cytochrome c biogenesis protein
IPK37_09830	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IPK37_09835	COG3005	denitrification pathway
IPK37_09840	COG2197	response regulator
IPK37_09855	COG0840	transmembrane signaling receptor activity
IPK37_09885	COG2205	protein histidine kinase activity
IPK37_09890	COG0745	RESPONSE REGULATOR receiver
IPK37_09910	COG0626	cystathionine gamma-synthase activity
IPK37_09915	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IPK37_09935	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IPK37_09955	COG0745	RESPONSE REGULATOR receiver
IPK37_09960	COG2205	protein histidine kinase activity
IPK37_09965	COG1136	(ABC) transporter
IPK37_09975	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
IPK37_09980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPK37_09980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPK37_09990	COG2070	2-Nitropropane dioxygenase
IPK37_10000	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IPK37_10005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IPK37_10010	COG2161	toxin-antitoxin pair type II binding
IPK37_10040	COG1937	Protein conserved in bacteria
IPK37_10050	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
IPK37_10070	COG0753	catalase activity
IPK37_10070	COG0693	protein deglycase activity
IPK37_10080	COG1846	Transcriptional regulator
IPK37_10085	COG1764	response to oxidative stress
IPK37_10090	COG2130	NADP-dependent
IPK37_10095	COG1902	pentaerythritol trinitrate reductase activity
IPK37_10100	COG0028	Belongs to the TPP enzyme family
IPK37_10105	COG3022	response to hydroperoxide
IPK37_10260	COG1396	sequence-specific DNA binding
IPK37_10280	COG1819	glycosyl
IPK37_10285	COG1051	belongs to the nudix hydrolase family
IPK37_10290	COG0443	Heat shock 70 kDa protein
IPK37_10295	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IPK37_10300	COG0484	heat shock protein binding
IPK37_10305	COG0789	Transcriptional regulator
IPK37_10320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IPK37_10325	COG0436	Aminotransferase
IPK37_10330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IPK37_10360	COG0477	Major facilitator Superfamily
IPK37_10370	COG5002	protein histidine kinase activity
IPK37_10420	COG0542	response to heat
IPK37_10435	COG0351	phosphomethylpyrimidine kinase
IPK37_10435	COG0352	thiamine-phosphate diphosphorylase activity
IPK37_10435	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IPK37_10445	COG0352	thiamine-phosphate diphosphorylase activity
IPK37_10450	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IPK37_10455	COG0708	Exodeoxyribonuclease III
IPK37_10465	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IPK37_10510	COG3795	YCII-related domain
IPK37_10520	COG0191	fructose-bisphosphate aldolase activity
IPK37_10540	COG1621	beta-fructofuranosidase activity
IPK37_10565	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IPK37_10570	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
IPK37_10580	COG0318	PFAM AMP-dependent synthetase and ligase
IPK37_10590	COG0151	Belongs to the GarS family
IPK37_10595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IPK37_10605	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IPK37_10610	COG0047	phosphoribosylformylglycinamidine synthase activity
IPK37_10615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IPK37_10625	COG5002	protein histidine kinase activity
IPK37_10630	COG2837	iron assimilation
IPK37_10640	COG0672	)-iron permease
IPK37_10690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IPK37_10705	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IPK37_10720	COG2801	Transposase and inactivated derivatives
IPK37_10730	COG1191	sigma factor activity
IPK37_10760	COG1360	Flagellar Motor Protein
IPK37_10765	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IPK37_10790	COG0741	lytic transglycosylase activity
IPK37_10800	COG1157	protein secretion by the type III secretion system
IPK37_10810	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IPK37_10815	COG1766	The M ring may be actively involved in energy transduction
IPK37_10820	COG1677	Flagellar hook-basal body complex protein FliE
IPK37_10840	COG2201	protein-glutamate methylesterase activity
IPK37_10845	COG0745	RESPONSE REGULATOR receiver
IPK37_10880	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IPK37_10895	COG1338	Plays a role in the flagellum-specific transport system
IPK37_10900	COG1987	bacterial-type flagellum assembly
IPK37_10905	COG1684	flagellar biosynthetic protein fliR
IPK37_10915	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IPK37_10965	COG0667	Aldo Keto reductase
IPK37_10970	COG3395	kinase activity
IPK37_10975	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IPK37_11000	COG1796	DNA polymerase
IPK37_11000	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IPK37_11005	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IPK37_11015	COG0667	Aldo Keto reductase
IPK37_11020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IPK37_11025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IPK37_11030	COG0569	domain protein
IPK37_11035	COG0406	alpha-ribazole phosphatase activity
IPK37_11040	COG2851	Citrate transporter
IPK37_11095	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IPK37_11135	COG2409	Drug exporters of the RND superfamily
IPK37_11150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IPK37_11155	COG0456	acetyltransferase
IPK37_11155	COG0454	-acetyltransferase
IPK37_11160	COG4085	toxin activity
IPK37_11160	COG1525	nuclease
IPK37_11160	COG0737	Belongs to the 5'-nucleotidase family
IPK37_11165	COG0745	RESPONSE REGULATOR receiver
IPK37_11180	COG3485	protocatechuate 3,4-dioxygenase
IPK37_11185	COG0735	belongs to the Fur family
IPK37_11190	COG0354	folic acid binding
IPK37_11220	COG0438	transferase activity, transferring glycosyl groups
IPK37_11230	COG0588	phosphoglycerate mutase activity
IPK37_11240	COG5002	protein histidine kinase activity
IPK37_11255	COG1329	Transcriptional regulator
IPK37_11260	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IPK37_11270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IPK37_11285	COG0215	cysteine-tRNA ligase activity
IPK37_11290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IPK37_11310	COG3842	ATPase activity
IPK37_11315	COG3833	ABC-type maltose transport systems, permease component
IPK37_11345	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IPK37_11345	COG0515	serine threonine protein kinase
IPK37_11440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPK37_11450	COG0657	acetylesterase activity
IPK37_11470	COG1461	Dihydroxyacetone kinase
IPK37_11475	COG2376	Dihydroxyacetone kinase
IPK37_11510	COG4251	negative regulation of phosphorylation
IPK37_11555	COG0058	SHG alpha-glucan phosphorylase activity
IPK37_11560	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPK37_11655	COG2337	Toxic component of a toxin-antitoxin (TA) module
IPK37_11665	COG1414	Transcriptional regulator
IPK37_11670	COG1414	Transcriptional regulator
IPK37_11695	COG1942	4-Oxalocrotonate Tautomerase
IPK37_11740	COG1960	acyl-CoA dehydrogenase activity
IPK37_11750	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IPK37_11765	COG1921	L-seryl-tRNASec selenium transferase activity
IPK37_11785	COG0709	Synthesizes selenophosphate from selenide and ATP
IPK37_11810	COG0437	4 iron, 4 sulfur cluster binding
IPK37_11815	COG0243	molybdopterin cofactor binding
IPK37_11815	COG3383	formate dehydrogenase (NAD+) activity
IPK37_11865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IPK37_11870	COG1136	(ABC) transporter
IPK37_11870	COG0577	efflux transmembrane transporter activity
IPK37_11875	COG0577	efflux transmembrane transporter activity
IPK37_11880	COG0840	transmembrane signaling receptor activity
IPK37_11890	COG1902	pentaerythritol trinitrate reductase activity
IPK37_11890	COG0446	pyridine nucleotide-disulphide oxidoreductase
IPK37_11895	COG0459	protein refolding
IPK37_11935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IPK37_11940	COG2205	protein histidine kinase activity
IPK37_11945	COG0745	RESPONSE REGULATOR receiver
IPK37_11990	COG3845	ABC transporter
IPK37_11995	COG1079	Belongs to the binding-protein-dependent transport system permease family
IPK37_12000	COG4603	Belongs to the binding-protein-dependent transport system permease family
IPK37_12005	COG1744	ABC transporter substrate-binding protein PnrA-like
IPK37_12025	COG0300	oxidoreductase activity
IPK37_12035	COG0402	S-adenosylhomocysteine deaminase activity
IPK37_12040	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IPK37_12055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPK37_12080	COG1061	Type III restriction enzyme res subunit
IPK37_12095	COG3590	peptidase
IPK37_12115	COG0318	PFAM AMP-dependent synthetase and ligase
IPK37_12135	COG1278	Cold shock
IPK37_12155	COG2814	Major facilitator Superfamily
IPK37_12170	COG3103	Sh3 type 3 domain protein
IPK37_12170	COG1388	LysM domain
IPK37_12170	COG0791	NLP P60 protein
IPK37_12175	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IPK37_12180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IPK37_12200	COG0318	PFAM AMP-dependent synthetase and ligase
IPK37_12205	COG1228	amidohydrolase
IPK37_12210	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IPK37_12215	COG0010	Belongs to the arginase family
IPK37_12225	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IPK37_12245	COG1024	Enoyl-CoA hydratase
IPK37_12260	COG1072	(Pantothenic acid kinase))
IPK37_12345	COG0714	Associated with various cellular activities
IPK37_12350	COG2425	protein containing a von Willebrand factor type A (vWA) domain
IPK37_12355	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IPK37_12370	COG1970	mechanosensitive ion channel activity
IPK37_12385	COG3263	regulation of cellular component size
IPK37_12400	COG0315	cyclic pyranopterin monophosphate synthase activity
IPK37_12405	COG0521	Mo-molybdopterin cofactor biosynthetic process
IPK37_12470	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IPK37_12475	COG1122	ATPase activity
IPK37_12500	COG0686	Belongs to the AlaDH PNT family
IPK37_12515	COG1053	succinate dehydrogenase
IPK37_12520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IPK37_12535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IPK37_12555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IPK37_12560	COG0084	hydrolase, TatD family'
IPK37_12565	COG0673	inositol 2-dehydrogenase activity
IPK37_12570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IPK37_12575	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IPK37_12595	COG0488	(ABC) transporter
IPK37_12600	COG1846	Transcriptional regulator
IPK37_12615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IPK37_12620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IPK37_12630	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IPK37_12635	COG0193	aminoacyl-tRNA hydrolase activity
IPK37_12640	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IPK37_12650	COG0405	Gamma-glutamyltransferase
IPK37_12655	COG0300	oxidoreductase activity
IPK37_12685	COG1012	belongs to the aldehyde dehydrogenase family
IPK37_12705	COG0148	phosphopyruvate hydratase activity
IPK37_12760	COG2755	lipolytic protein G-D-S-L family
IPK37_12775	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPK37_12780	COG2364	Membrane
IPK37_12785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IPK37_12795	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPK37_12805	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IPK37_12815	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IPK37_12825	COG1072	(Pantothenic acid kinase))
IPK37_12830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IPK37_12835	COG0736	holo-[acyl-carrier-protein] synthase activity
IPK37_12850	COG1426	Protein conserved in bacteria
IPK37_12855	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
IPK37_12860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IPK37_12875	COG1214	PFAM Peptidase M22, glycoprotease
IPK37_12875	COG0456	acetyltransferase
IPK37_12885	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IPK37_12895	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IPK37_12900	COG2723	6-phospho-beta-galactosidase activity
IPK37_12910	COG1169	isochorismate synthase
IPK37_12915	COG2226	methyltransferase
IPK37_12930	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPK37_12935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPK37_12940	COG0649	NAD binding
IPK37_12955	COG1034	ATP synthesis coupled electron transport
IPK37_12960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IPK37_12965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPK37_12970	COG0839	Belongs to the complex I subunit 6 family
IPK37_12975	COG0713	ATP synthesis coupled electron transport
IPK37_12995	COG0142	geranyltranstransferase activity
IPK37_13000	COG1309	transcriptional regulator
IPK37_13010	COG1013	pyruvate-flavodoxin oxidoreductase activity
IPK37_13015	COG0674	pyruvate-flavodoxin oxidoreductase activity
IPK37_13015	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IPK37_13020	COG0501	Belongs to the peptidase M48B family
IPK37_13050	COG0252	asparaginase activity
IPK37_13055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IPK37_13065	COG1666	GTP binding
IPK37_13080	COG0456	acetyltransferase
IPK37_13115	COG1024	Enoyl-CoA hydratase
IPK37_13115	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPK37_13120	COG0281	malic enzyme
IPK37_13140	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
IPK37_13145	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
IPK37_13150	COG1268	BioY protein
IPK37_13155	COG1122	ATPase activity
IPK37_13160	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IPK37_13175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IPK37_13180	COG2030	dehydratase
IPK37_13190	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IPK37_13195	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IPK37_13215	COG0250	Participates in transcription elongation, termination and antitermination
IPK37_13220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IPK37_13225	COG0081	regulation of translation
IPK37_13230	COG0456	acetyltransferase
IPK37_13235	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IPK37_13240	COG0222	ribosome binding
IPK37_13245	COG0085	RNA polymerase activity
IPK37_13250	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IPK37_13255	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IPK37_13260	COG0049	tRNA binding
IPK37_13265	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IPK37_13270	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IPK37_13280	COG0297	glycogen (starch) synthase activity
IPK37_13285	COG0051	transcription antitermination factor activity, RNA binding
IPK37_13290	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IPK37_13300	COG0089	rRNA binding
IPK37_13305	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IPK37_13310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IPK37_13315	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IPK37_13320	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IPK37_13325	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IPK37_13330	COG0255	Belongs to the universal ribosomal protein uL29 family
IPK37_13335	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IPK37_13340	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IPK37_13345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IPK37_13350	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IPK37_13360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IPK37_13365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IPK37_13370	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IPK37_13375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IPK37_13380	COG1841	ribosomal large subunit assembly
IPK37_13385	COG0200	Binds to the 23S rRNA
IPK37_13395	COG0563	adenylate kinase activity
IPK37_13405	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IPK37_13410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IPK37_13415	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IPK37_13420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IPK37_13430	COG0202	RNA polymerase activity
IPK37_13440	COG0101	tRNA pseudouridine synthase activity
IPK37_13465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IPK37_13470	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IPK37_13475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPK37_13480	COG0288	reversible hydration of carbon dioxide
IPK37_13485	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
IPK37_13485	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
IPK37_13515	COG1722	exodeoxyribonuclease VII activity
IPK37_13520	COG1570	exodeoxyribonuclease VII activity
IPK37_13525	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IPK37_13535	COG0438	transferase activity, transferring glycosyl groups
IPK37_13550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IPK37_13555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IPK37_13570	COG1322	Protein conserved in bacteria
IPK37_13575	COG0012	GTP binding
IPK37_13590	COG0110	maltose O-acetyltransferase activity
IPK37_13605	COG0493	'glutamate synthase
IPK37_13605	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
IPK37_13610	COG0505	Belongs to the CarA family
IPK37_13615	COG4608	Belongs to the ABC transporter superfamily
IPK37_13620	COG0444	Belongs to the ABC transporter superfamily
IPK37_13625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPK37_13630	COG0601	transmembrane transport
IPK37_13635	COG0747	negative chemotaxis
IPK37_13640	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IPK37_13645	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IPK37_13650	COG0494	nUDIX hydrolase
IPK37_13655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IPK37_13660	COG1217	gtp-binding protein TYPA
IPK37_13680	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IPK37_13685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IPK37_13695	COG2326	polyphosphate kinase activity
IPK37_13700	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPK37_13745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPK37_13760	COG0583	DNA-binding transcription factor activity
IPK37_13765	COG1611	Belongs to the LOG family
IPK37_13780	COG1024	Enoyl-CoA hydratase
IPK37_13790	COG4122	O-methyltransferase activity
IPK37_13795	COG1595	DNA-templated transcription, initiation
IPK37_13810	COG3243	poly(R)-hydroxyalkanoic acid synthase
IPK37_13830	COG1131	(ABC) transporter
IPK37_13835	COG3559	Exporter of polyketide antibiotics
IPK37_13840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPK37_13855	COG2239	Acts as a magnesium transporter
IPK37_13860	COG2301	Belongs to the HpcH HpaI aldolase family
IPK37_13865	COG2301	Belongs to the HpcH HpaI aldolase family
IPK37_13870	COG3360	Dodecin
IPK37_13900	COG0346	lactoylglutathione lyase activity
IPK37_13940	COG0006	proline dipeptidase activity
IPK37_13960	COG2801	Transposase and inactivated derivatives
IPK37_13985	COG2801	Transposase and inactivated derivatives
IPK37_14010	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPK37_14045	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IPK37_14050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IPK37_14060	COG2030	dehydratase
IPK37_14070	COG0613	PHP domain protein
IPK37_14075	COG2095	MarC family integral membrane protein
IPK37_14125	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPK37_14165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IPK37_14210	COG3480	Lon protease (S16) C-terminal proteolytic domain
IPK37_14220	COG1615	UPF0182 protein
IPK37_14260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IPK37_14275	COG1252	NADH dehydrogenase
IPK37_14280	COG0612	Peptidase, M16
IPK37_14295	COG0483	inositol monophosphate 1-phosphatase activity
IPK37_14315	COG2326	polyphosphate kinase activity
IPK37_14330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IPK37_14340	COG2135	peptidase activity
IPK37_14350	COG1595	DNA-templated transcription, initiation
IPK37_14370	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
IPK37_14390	COG0179	Fumarylacetoacetate (FAA) hydrolase
IPK37_14420	COG2385	sporulation resulting in formation of a cellular spore
IPK37_14420	COG2247	cell wall binding repeat
IPK37_14455	COG0778	Nitroreductase
IPK37_14455	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IPK37_14460	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IPK37_14480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IPK37_14510	COG2354	Protein conserved in bacteria
IPK37_14515	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IPK37_14520	COG0745	RESPONSE REGULATOR receiver
IPK37_14525	COG5002	protein histidine kinase activity
IPK37_14540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IPK37_14545	COG2197	response regulator
IPK37_14550	COG3214	Protein conserved in bacteria
IPK37_14570	COG2337	Toxic component of a toxin-antitoxin (TA) module
IPK37_14580	COG0653	protein targeting
IPK37_14635	COG2902	Dehydrogenase
IPK37_14655	COG1674	ftsk spoiiie
IPK37_14700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IPK37_14710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IPK37_14745	COG2884	Cell division ATP-binding protein ftsE
IPK37_14755	COG1196	nuclear chromosome segregation
IPK37_14755	COG0741	lytic transglycosylase activity
IPK37_14755	COG0739	heme binding
IPK37_14760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IPK37_14775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IPK37_14780	COG0513	Belongs to the DEAD box helicase family
IPK37_14785	COG1678	Uncharacterized ACR, COG1678
IPK37_14810	COG2755	lipolytic protein G-D-S-L family
IPK37_14810	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPK37_14820	COG1335	isochorismatase
IPK37_14830	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IPK37_14840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPK37_14845	COG0765	amino acid transport
IPK37_14855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IPK37_14860	COG0765	amino acid transport
IPK37_14865	COG1126	abc transporter atp-binding protein
IPK37_14875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IPK37_14895	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IPK37_14900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IPK37_14920	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IPK37_14925	COG0156	8-amino-7-oxononanoate synthase activity
IPK37_14930	COG1063	alcohol dehydrogenase
IPK37_14945	COG1705	Flagellar rod assembly protein muramidase FlgJ
IPK37_15070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IPK37_15090	COG1131	(ABC) transporter
IPK37_15135	COG1917	Cupin 2, conserved barrel domain protein
IPK37_15135	COG4977	sequence-specific DNA binding
IPK37_15140	COG0456	acetyltransferase
IPK37_15180	COG0739	heme binding
IPK37_15180	COG0741	lytic transglycosylase activity
IPK37_15180	COG1196	nuclear chromosome segregation
IPK37_15185	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IPK37_15315	COG0629	single-stranded DNA binding
IPK37_15340	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IPK37_15345	COG1946	Acyl-CoA thioesterase
IPK37_15355	COG0366	Alpha amylase catalytic
IPK37_15365	COG0668	transmembrane transport
IPK37_15385	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IPK37_15430	COG0544	peptidyl-prolyl cis-trans isomerase activity
IPK37_15435	COG0740	serine-type endopeptidase activity
IPK37_15440	COG0740	serine-type endopeptidase activity
IPK37_15455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IPK37_15465	COG0525	valine-tRNA ligase activity
IPK37_15475	COG0277	FAD linked oxidase domain protein
IPK37_15480	COG2340	Cysteine-rich secretory protein family
IPK37_15490	COG1028	Short-chain dehydrogenase reductase Sdr
IPK37_15520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IPK37_15530	COG0285	dihydrofolate synthase activity
IPK37_15540	COG0105	UTP biosynthetic process
IPK37_15550	COG1132	(ABC) transporter
IPK37_15555	COG0515	serine threonine protein kinase
IPK37_15560	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IPK37_15575	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IPK37_15580	COG1185	polyribonucleotide nucleotidyltransferase activity
IPK37_15585	COG1132	(ABC) transporter
IPK37_15620	COG0167	dihydroorotate dehydrogenase activity
IPK37_15625	COG0674	pyruvate-flavodoxin oxidoreductase activity
IPK37_15625	COG1013	pyruvate-flavodoxin oxidoreductase activity
IPK37_15625	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IPK37_15625	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IPK37_15630	COG0493	'glutamate synthase
IPK37_15640	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IPK37_15645	COG1584	GPR1 FUN34 yaaH family protein
IPK37_15655	COG1966	Carbon starvation protein
IPK37_15675	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IPK37_15680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IPK37_15685	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IPK37_15695	COG1674	ftsk spoiiie
IPK37_15705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPK37_15715	COG1058	Belongs to the CinA family
IPK37_15715	COG1546	Belongs to the CinA family
IPK37_15730	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IPK37_15735	COG1201	RNA secondary structure unwinding
IPK37_15745	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IPK37_15750	COG2137	regulation of response to DNA damage stimulus
IPK37_15765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IPK37_15795	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IPK37_15805	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IPK37_15810	COG2813	Specifically methylates the guanine in position
IPK37_15840	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IPK37_15875	COG0477	Major facilitator Superfamily
IPK37_15885	COG0268	Binds directly to 16S ribosomal RNA
IPK37_15900	COG0495	leucyl-tRNA aminoacylation
IPK37_15905	COG1307	EDD domain protein, DegV family
IPK37_15910	COG0322	excinuclease ABC activity
IPK37_15915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IPK37_15920	COG0583	DNA-binding transcription factor activity
IPK37_15925	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IPK37_15935	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IPK37_15940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IPK37_15960	COG3185	4-Hydroxyphenylpyruvate dioxygenase
IPK37_15985	COG3842	ATPase activity
IPK37_16015	COG2733	membrane
IPK37_16025	COG1022	Amp-dependent synthetase and ligase
IPK37_16040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPK37_16060	COG2873	o-acetylhomoserine
IPK37_16065	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
IPK37_16075	COG1846	Transcriptional regulator
IPK37_16125	COG2318	DinB family
IPK37_16130	COG1643	Atp-dependent helicase
IPK37_16165	COG0589	response to stress
IPK37_16195	COG0481	GTPase activity
IPK37_16200	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IPK37_16230	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IPK37_16235	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IPK37_16265	COG1420	regulation of RNA biosynthetic process
IPK37_16270	COG0484	heat shock protein binding
IPK37_16290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IPK37_16300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IPK37_16305	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
IPK37_16310	COG1172	Belongs to the binding-protein-dependent transport system permease family
IPK37_16345	COG2031	fatty acid transporter
IPK37_16380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IPK37_16420	COG1381	Involved in DNA repair and RecF pathway recombination
IPK37_16425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IPK37_16440	COG0442	prolyl-tRNA aminoacylation
IPK37_16465	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IPK37_16470	COG0358	DNA primase activity
IPK37_16560	COG2801	Transposase and inactivated derivatives
IPK37_16610	COG4691	Plasmid stability protein
IPK37_16625	COG1216	Glycosyl transferase, family 2
IPK37_16640	COG3573	Dehydrogenase
IPK37_16680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IPK37_16730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IPK37_16735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IPK37_16750	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IPK37_16765	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IPK37_16765	COG0235	Class ii aldolase
IPK37_16770	COG1063	alcohol dehydrogenase
IPK37_16780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IPK37_16800	COG0561	phosphatase activity
IPK37_16815	COG0604	alcohol dehydrogenase
IPK37_16845	COG2233	PERMEase
IPK37_16850	COG0493	'glutamate synthase
IPK37_16850	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IPK37_16855	COG0402	S-adenosylhomocysteine deaminase activity
IPK37_16885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IPK37_16890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IPK37_16900	COG1304	FMN binding
IPK37_16905	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IPK37_16905	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IPK37_16905	COG0674	pyruvate-flavodoxin oxidoreductase activity
IPK37_16905	COG1013	pyruvate-flavodoxin oxidoreductase activity
IPK37_16915	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IPK37_16945	COG3842	ATPase activity
IPK37_16955	COG1840	ABC-type Fe3 transport system, periplasmic component
IPK37_16980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IPK37_16985	COG1560	Kdo2-lipid A biosynthetic process
IPK37_16990	COG0438	transferase activity, transferring glycosyl groups
IPK37_17000	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IPK37_17005	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IPK37_17010	COG0217	transcriptional regulatory protein
IPK37_17020	COG1595	DNA-templated transcription, initiation
IPK37_17025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IPK37_17030	COG0632	four-way junction helicase activity
IPK37_17035	COG2255	four-way junction helicase activity
IPK37_17040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPK37_17045	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IPK37_17050	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IPK37_17055	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IPK37_17060	COG1196	nuclear chromosome segregation
IPK37_17070	COG0124	histidyl-tRNA synthetase
IPK37_17090	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IPK37_17095	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IPK37_17110	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IPK37_17115	COG1160	GTP binding
IPK37_17135	COG1716	ATPase activity
IPK37_17155	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPK37_17155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IPK37_17165	COG0205	6-phosphofructokinase activity
IPK37_17175	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IPK37_17180	COG0443	Heat shock 70 kDa protein
IPK37_17205	COG2337	Toxic component of a toxin-antitoxin (TA) module
IPK37_17235	COG0346	lactoylglutathione lyase activity
IPK37_17240	COG0824	Thioesterase
IPK37_17260	COG1216	Glycosyl transferase, family 2
IPK37_17270	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IPK37_17275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IPK37_17285	COG0805	protein transport
IPK37_17290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IPK37_17315	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IPK37_17320	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IPK37_17325	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IPK37_17340	COG4122	O-methyltransferase activity
IPK37_17365	COG1131	(ABC) transporter
IPK37_17410	COG1222	aaa ATPase
IPK37_17420	COG0517	IMP dehydrogenase activity
IPK37_17420	COG1994	Peptidase M50
IPK37_17435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IPK37_17440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IPK37_17445	COG1410	methionine synthase
IPK37_17445	COG0646	methionine synthase
IPK37_17475	COG0598	Magnesium transport protein CorA
IPK37_17480	COG1968	undecaprenyl-diphosphatase activity
IPK37_17500	COG0754	glutathionylspermidine amidase activity
IPK37_17545	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
IPK37_17550	COG0514	ATP-dependent DNA helicase (RecQ)
IPK37_17570	COG1881	PFAM PEBP family protein
IPK37_17595	COG1119	ATPase activity
IPK37_17605	COG0297	glycogen (starch) synthase activity
IPK37_17640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IPK37_17650	COG1132	(ABC) transporter
IPK37_17660	COG0488	(ABC) transporter
IPK37_17670	COG0318	PFAM AMP-dependent synthetase and ligase
IPK37_17675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IPK37_17770	COG0697	spore germination
IPK37_17775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IPK37_17780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IPK37_17785	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IPK37_17825	COG2091	lysine biosynthetic process via aminoadipic acid
IPK37_17845	COG2151	metal-sulfur cluster biosynthetic enzyme
IPK37_17860	COG0396	ATPase activity
IPK37_17920	COG0247	lactate metabolic process
IPK37_17920	COG2181	nitrate reductase activity
IPK37_17925	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IPK37_17930	COG2086	electron transfer activity
IPK37_17940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IPK37_17945	COG0109	protoheme IX farnesyltransferase activity
IPK37_17955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IPK37_17975	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IPK37_17980	COG0149	triose-phosphate isomerase activity
IPK37_17985	COG0126	phosphoglycerate kinase activity
IPK37_17990	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IPK37_17995	COG1481	regulation of sporulation
IPK37_18005	COG1660	Displays ATPase and GTPase activities
IPK37_18010	COG0322	excinuclease ABC activity
IPK37_18050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IPK37_18065	COG5006	permease, DMT superfamily
IPK37_18075	COG0318	PFAM AMP-dependent synthetase and ligase
IPK37_18080	COG1960	acyl-CoA dehydrogenase activity
IPK37_18090	COG1028	Short-chain dehydrogenase reductase Sdr
IPK37_18105	COG0765	amino acid transport
IPK37_18110	COG1126	abc transporter atp-binding protein
IPK37_18135	COG0556	nucleotide-excision repair
IPK37_18145	COG1476	TRANSCRIPTIONal
IPK37_18155	COG0237	dephospho-CoA kinase activity
IPK37_18155	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IPK37_18170	COG3842	ATPase activity
IPK37_18175	COG0395	ABC-type sugar transport system, permease component
IPK37_18185	COG0539	negative regulation of cytoplasmic translation
IPK37_18190	COG2226	methyltransferase
IPK37_18200	COG0657	acetylesterase activity
IPK37_18220	COG1028	Short-chain dehydrogenase reductase Sdr
IPK37_18275	COG0469	pyruvate kinase activity
IPK37_18285	COG0069	glutamate synthase activity
IPK37_18285	COG0067	glutamate synthase
IPK37_18285	COG0070	glutamate synthase
IPK37_18310	COG0133	tryptophan synthase activity
IPK37_18315	COG0134	indole-3-glycerol-phosphate synthase activity
IPK37_18355	COG3845	ABC transporter
IPK37_18370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IPK37_18375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IPK37_18380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IPK37_18380	COG2755	lipolytic protein G-D-S-L family
IPK37_18385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IPK37_18390	COG0508	dehydrogenase complex catalyzes the overall conversion of
IPK37_18400	COG0321	lipoyl(octanoyl) transferase activity
IPK37_18405	COG1131	(ABC) transporter
IPK37_18415	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IPK37_18460	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IPK37_18530	COG0668	transmembrane transport
IPK37_18580	COG2326	polyphosphate kinase activity
IPK37_18590	COG1793	dna ligase
IPK37_18600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IPK37_18610	COG3253	May function as heme-dependent peroxidase
IPK37_18620	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IPK37_18635	COG0183	Belongs to the thiolase family
IPK37_18640	COG1250	3-hydroxyacyl-CoA dehydrogenase
IPK37_18640	COG1024	Enoyl-CoA hydratase
IPK37_18645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IPK37_18655	COG2197	response regulator
IPK37_18670	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
IPK37_18685	COG3795	YCII-related domain
IPK37_18695	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IPK37_18720	COG2124	cytochrome p450
IPK37_18730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IPK37_18745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IPK37_18750	COG0531	amino acid
IPK37_18755	COG0569	domain protein
IPK37_18780	COG0756	dUTP diphosphatase activity
IPK37_18795	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IPK37_18795	COG3253	May function as heme-dependent peroxidase
IPK37_18820	COG1349	DNA-binding transcription factor activity
IPK37_18830	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPK37_18830	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IPK37_18830	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IPK37_18840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPK37_18845	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IPK37_18850	COG1063	alcohol dehydrogenase
IPK37_18855	COG2213	PTS system mannitol-specific
IPK37_18855	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IPK37_18890	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IPK37_18895	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IPK37_18900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IPK37_18935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IPK37_18940	COG2264	protein methyltransferase activity
IPK37_18945	COG0587	DNA-directed DNA polymerase activity
IPK37_18970	COG0142	geranyltranstransferase activity
IPK37_18980	COG3942	CHAP domain
IPK37_18980	COG1388	LysM domain
IPK37_18985	COG0515	serine threonine protein kinase
IPK37_18985	COG2815	serine threonine protein kinase
IPK37_18990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IPK37_18995	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IPK37_19020	COG1940	carbohydrate kinase activity
IPK37_19030	COG0003	Pfam Anion-transporting ATPase
IPK37_19070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IPK37_19080	COG1845	cytochrome c oxidase, subunit III
IPK37_19085	COG2010	Cytochrome c
IPK37_19090	COG0723	plastoquinol--plastocyanin reductase activity
IPK37_19095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IPK37_19100	COG1872	DUF167
IPK37_19110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IPK37_19110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IPK37_19115	COG1376	ErfK ybiS ycfS ynhG family protein
IPK37_19125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IPK37_19130	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IPK37_19135	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IPK37_19155	COG1929	Belongs to the glycerate kinase type-1 family
IPK37_19180	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IPK37_19195	COG0107	imidazoleglycerol-phosphate synthase activity
IPK37_19200	COG0180	Tryptophanyl-tRNA synthetase
IPK37_19215	COG4129	membrane
IPK37_19225	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IPK37_19230	COG0140	phosphoribosyl-ATP diphosphatase activity
IPK37_19250	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
IPK37_19260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IPK37_19265	COG3201	nicotinamide mononucleotide transporter
IPK37_19270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IPK37_19275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPK37_19275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IPK37_19310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IPK37_19315	COG1072	(Pantothenic acid kinase))
IPK37_19320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IPK37_19330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IPK37_19335	COG0242	peptide deformylase activity
IPK37_19350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IPK37_19360	COG1758	RNA polymerase activity
IPK37_19365	COG0194	GDP metabolic process
IPK37_19375	COG1605	Chorismate mutase
IPK37_19375	COG0287	Prephenate dehydrogenase
IPK37_19380	COG0284	orotidine-5'-phosphate decarboxylase activity
IPK37_19385	COG0167	dihydroorotate dehydrogenase activity
IPK37_19390	COG0543	2 iron, 2 sulfur cluster binding
IPK37_19395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IPK37_19400	COG0505	Belongs to the CarA family
IPK37_19405	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IPK37_19410	COG0540	Belongs to the ATCase OTCase family
IPK37_19415	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IPK37_19425	COG1012	belongs to the aldehyde dehydrogenase family
IPK37_19435	COG0166	Belongs to the GPI family
IPK37_19460	COG2391	methyltransferase activity
IPK37_19465	COG0425	Belongs to the sulfur carrier protein TusA family
IPK37_19470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IPK37_19475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IPK37_19505	COG4941	Belongs to the sigma-70 factor family
IPK37_19520	COG2353	YceI-like domain
IPK37_19525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IPK37_19530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IPK37_19535	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IPK37_19540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IPK37_19545	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IPK37_19550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IPK37_19555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IPK37_19560	COG0747	negative chemotaxis
IPK37_19565	COG0601	transmembrane transport
IPK37_19570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IPK37_19575	COG0444	Belongs to the ABC transporter superfamily
IPK37_19590	COG2409	Drug exporters of the RND superfamily
IPK37_19600	COG3132	Protein of unknown function, DUF480
IPK37_19615	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IPK37_19660	COG3012	SEC-C Motif Domain Protein
IPK37_19665	COG0494	nUDIX hydrolase
IPK37_19670	COG0504	CTP synthase activity
IPK37_19675	COG0497	DNA recombination
IPK37_19680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IPK37_19695	COG0647	UMP catabolic process