locus-tag class description HHJ60_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HHJ60_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HHJ60_00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HHJ60_00020 ENOG4105EX9 Membrane HHJ60_00025 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) HHJ60_00030 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HHJ60_00035 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HHJ60_00040 ENOG41080IJ Diacylglycerol kinase HHJ60_00045 ENOG4107RB3 L-asparaginase HHJ60_00055 ENOG4107ZVW dihydroneopterin aldolase HHJ60_00060 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HHJ60_00070 ENOG41066DY Membrane HHJ60_00075 ENOG4108ZMA Outer membrane lipoprotein HHJ60_00080 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HHJ60_00085 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HHJ60_00090 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HHJ60_00095 ENOG4105EUB pirin domain protein HHJ60_00100 ENOG4108YYH Nadph-dependent fmn reductase HHJ60_00105 ENOG4108ETH Formylglycinamide ribotide synthetase HHJ60_00110 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HHJ60_00120 ENOG41068D6 Glycosyltransferase HHJ60_00135 ENOG4105CI3 gtp-binding protein typa HHJ60_00140 ENOG4105C5F glutamine synthetase HHJ60_00150 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HHJ60_00155 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HHJ60_00160 ENOG4108JU5 Magnesium and cobalt efflux protein HHJ60_00165 ENOG4105DMR ABC, transporter HHJ60_00170 ENOG4105GBT ABC transporter HHJ60_00175 ENOG4106PMH Extracellular solute-binding protein family 3 HHJ60_00180 ENOG4105E5Z arginine transporter ATP-binding subunit HHJ60_00190 ENOG4105K89 arsenate reductase HHJ60_00205 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HHJ60_00210 ENOG4106KVJ cytochrome C assembly protein HHJ60_00215 ENOG4108JU6 CBS domain protein HHJ60_00220 ENOG4105M8K biopolymer transport protein HHJ60_00225 ENOG4105M15 transport protein ExbD HHJ60_00230 ENOG41067XB TonB family HHJ60_00235 ENOG4105CTS PTS system mannitol-specific HHJ60_00240 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase HHJ60_00245 ENOG4105E61 Mannitol repressor protein HHJ60_00250 ENOG4108ST3 glycosyltransferase HHJ60_00255 ENOG4105C2M dna polymerase I HHJ60_00260 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) HHJ60_00265 ENOG4105C94 Transporter HHJ60_00290 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HHJ60_00295 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HHJ60_00300 ENOG4108IJ0 Aspartate ammonia-lyase HHJ60_00305 ENOG4108IQE Amp-dependent synthetase and ligase HHJ60_00310 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HHJ60_00315 ENOG4108WPU DNA polymerase III subunit psi HHJ60_00320 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HHJ60_00330 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) HHJ60_00335 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) HHJ60_00340 ENOG4105CWM branched-chain amino acid transport system II carrier protein HHJ60_00345 ENOG4105BZM domain protein HHJ60_00360 ENOG4108RRZ Transcription elongation factor GreB HHJ60_00370 ENOG410624X efflux transporter, rnd family, mfp subunit HHJ60_00375 ENOG4105BZS acriflavin resistance protein HHJ60_00380 ENOG4106N3A copper homeostasis protein cutc HHJ60_00385 ENOG4105CK1 PTS System HHJ60_00395 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HHJ60_00400 ENOG4105VZJ PTS System HHJ60_00405 ENOG4105VCP PTS System HHJ60_00415 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HHJ60_00425 ENOG4105C4R Atp-dependent dna helicase HHJ60_00445 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HHJ60_00470 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HHJ60_00480 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HHJ60_00485 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HHJ60_00490 ENOG4105D9N nucleoside HHJ60_00495 ENOG4105GPY SprT protein HHJ60_00500 ENOG41065S8 Opacity family porin protein HHJ60_00505 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HHJ60_00515 ENOG4105W8Z 4'-phosphopantetheinyl transferase HHJ60_00520 ENOG4107QJR hflk protein HHJ60_00525 ENOG4105EPW hflc protein HHJ60_00535 ENOG4105E66 phosphoriboisomerase A HHJ60_00540 ENOG4108JQ1 Dehydrogenase HHJ60_00550 ENOG4105HHA aminodeoxychorismate lyase HHJ60_00555 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HHJ60_00560 ENOG4107QRG dna polymerase iii HHJ60_00565 ENOG4105F8V Hydrolase, tatD family HHJ60_00570 ENOG4105RX8 Protein of unknown function (DUF1523) HHJ60_00575 ENOG4105C37 (CBS) domain HHJ60_00580 ENOG4105VFB Binds the 23S rRNA (By similarity) HHJ60_00585 ENOG4105C25 Primosomal protein n' HHJ60_00590 ENOG41063M6 Cell Division Protein HHJ60_00600 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HHJ60_00605 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HHJ60_00610 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) HHJ60_00620 ENOG4105K59 histidine triad (HIT) protein HHJ60_00625 ENOG4105TMB Formate nitrite transporter HHJ60_00630 ENOG4105C6N Formate acetyltransferase HHJ60_00635 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family HHJ60_00640 ENOG4105F1A Pyruvate formate-lyase HHJ60_00650 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HHJ60_00655 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HHJ60_00660 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HHJ60_00665 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HHJ60_00670 ENOG4105C2J ABC transporter HHJ60_00675 ENOG4108HWV )-transporter HHJ60_00680 ENOG4108M1T Cytochrome c-type biogenesis protein HHJ60_00685 ENOG4108M1T Cytochrome c-type biogenesis protein HHJ60_00690 ENOG4107QX9 Thiol disulfide interChange protein HHJ60_00695 ENOG4105DA4 cytochrome c-type biogenesis protein HHJ60_00700 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) HHJ60_00705 ENOG4105X3C heme exporter protein HHJ60_00710 ENOG41060IM Heme exporter protein HHJ60_00715 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HHJ60_00720 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HHJ60_00725 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HHJ60_00730 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HHJ60_00735 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HHJ60_00740 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HHJ60_00745 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HHJ60_00750 ENOG4105C2W permease HHJ60_00755 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HHJ60_00760 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HHJ60_00765 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HHJ60_00775 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HHJ60_00780 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HHJ60_00785 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HHJ60_00790 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HHJ60_00795 ENOG4105DFS Conserved Protein HHJ60_00800 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HHJ60_00805 ENOG4105CIH Imidazole acetol-phosphate transaminase HHJ60_00815 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HHJ60_00820 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HHJ60_00825 ENOG4105DMQ Methyltransferase HHJ60_00830 ENOG4105CIC tryptophan-specific transport protein HHJ60_00835 ENOG4105F0N pyrophosphate phospho-hydrolase HHJ60_00840 ENOG4105ERG peptidase m48, ste24p HHJ60_00850 ENOG4108K5P (LipO)protein HHJ60_00860 ENOG4108UM1 dedA family HHJ60_00865 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) HHJ60_00870 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HHJ60_00875 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HHJ60_00885 ENOG4107VXZ Hydrolase HHJ60_00890 ENOG4108UW5 maltose o-acetyltransferase HHJ60_00895 ENOG4105W39 Membrane HHJ60_00905 ENOG4105CSA Coproporphyrinogen iii oxidase HHJ60_00910 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HHJ60_00915 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HHJ60_00920 ENOG4105C7N Xanthine uracil vitamin C permease HHJ60_00930 ENOG4105CMR udp-glucose 4-epimerase HHJ60_00935 ENOG4105EYM Major Facilitator superfamily HHJ60_00940 ENOG4105C09 Bile acid HHJ60_00945 ENOG4105BZU Histidine kinase HHJ60_00960 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HHJ60_00965 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HHJ60_00970 ENOG4105CTQ phosphohexokinase HHJ60_00995 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) HHJ60_01000 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HHJ60_01005 ENOG4105C3F Signal peptidase i HHJ60_01020 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HHJ60_01025 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HHJ60_01030 ENOG4105C2N RNA methyltransferase TrmH family group 3 HHJ60_01035 ENOG4105C0R drug resistance transporter emrb qaca subfamily HHJ60_01040 ENOG4105CW7 secretion protein, HlyD family HHJ60_01045 ENOG4105NTK Transcriptional repressor Mpra HHJ60_01060 ENOG4105NTK Transcriptional repressor Mpra HHJ60_01065 ENOG4105HMI Membrane HHJ60_01070 ENOG4105D5K Hemolysin activator protein HHJ60_01075 ENOG4105CKT filamentous hemagglutinin HHJ60_01075 ENOG4105CKT filamentous hemagglutinin HHJ60_01175 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HHJ60_01180 ENOG4105QYV Membrane HHJ60_01185 ENOG4105K46 50S ribosomal protein l27 HHJ60_01190 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HHJ60_01195 ENOG4105EAH synthase HHJ60_01200 ENOG4105WPN DNA integration recombination invertion protein HHJ60_01205 ENOG4105K63 Thioredoxin HHJ60_01210 ENOG4105C5I Dehydrogenase HHJ60_01215 ENOG4105C28 cystathionine HHJ60_01235 ENOG4108KU3 Integrase HHJ60_01295 ENOG4108UUM single-stranded DNA-binding protein HHJ60_01345 ENOG4107EPN Domain of unknown function (DUF1508) HHJ60_01350 ENOG4105VUH addiction module killer protein HHJ60_01355 ENOG4105YES addiction module antidote protein HHJ60_01370 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HHJ60_01410 ENOG4105RWQ Protein of unknown function (DUF1364) HHJ60_01435 ENOG4107EPN Domain of unknown function (DUF1508) HHJ60_01540 ENOG4108UUM single-stranded DNA-binding protein HHJ60_01565 ENOG4105WXW Antirepressor HHJ60_01575 ENOG4108KU3 Integrase HHJ60_01585 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HHJ60_01595 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit HHJ60_01600 ENOG41063VX Inherit from COG: glutaredoxin-related protein HHJ60_01610 ENOG4105DFS Conserved Protein HHJ60_01615 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HHJ60_01645 ENOG4108JQC penicillin-binding protein 1A HHJ60_01670 ENOG4105E4G Type IV pilus HHJ60_01675 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HHJ60_01680 ENOG4105D49 3-dehydroquinate synthase HHJ60_01685 ENOG4105DFE Dna adenine methylase HHJ60_01700 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HHJ60_01705 ENOG4105M6F mutator MutT protein HHJ60_01710 ENOG4108JA2 transcriptioN-repair coupling factor HHJ60_01725 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HHJ60_01770 ENOG4105K4U addiction module toxin, RelE StbE family HHJ60_01830 ENOG4105C6T cysteine synthase HHJ60_01840 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HHJ60_01845 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HHJ60_01850 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HHJ60_01855 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HHJ60_01860 ENOG4105EYA deoxyribonuclease HHJ60_01865 ENOG4105D52 delta-aminolevulinic acid dehydratase HHJ60_01870 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HHJ60_01875 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HHJ60_01880 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HHJ60_01885 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) HHJ60_01890 ENOG4105JC1 sterol-binding domain protein HHJ60_01895 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HHJ60_01900 ENOG4105C8P )-transporter HHJ60_01905 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) HHJ60_01910 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HHJ60_01915 ENOG4108R96 Methyltransferase, YaeB family HHJ60_01920 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HHJ60_01925 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HHJ60_01930 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HHJ60_01935 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HHJ60_01945 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) HHJ60_01950 ENOG4105E07 UPF0149 protein HHJ60_01955 ENOG4107RAQ aminopeptidase HHJ60_01960 ENOG4105D0A hydroxylase HHJ60_01965 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HHJ60_01970 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HHJ60_01975 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HHJ60_01980 ENOG4105C2J ABC transporter HHJ60_01985 ENOG4105CNN ABC, transporter HHJ60_01990 ENOG4107RYR Transcriptional regulator, Crp Fnr family HHJ60_01995 ENOG4105YP7 UPF0270 protein HHJ60_02000 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) HHJ60_02010 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HHJ60_02030 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HHJ60_02040 ENOG4105QEK Transcriptional regulator HHJ60_02045 ENOG4108R66 Conserved Protein HHJ60_02050 ENOG4105EVU fructokinase HHJ60_02055 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) HHJ60_02065 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HHJ60_02085 ENOG4107ENK receptor HHJ60_02090 ENOG41090JE Utilization Protein HHJ60_02095 ENOG4105PYN Pyridoxamine 5-phosphate oxidase-related HHJ60_02105 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HHJ60_02110 ENOG4105DFF Rod shape-determining protein mreb HHJ60_02115 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HHJ60_02120 ENOG4108UUM single-stranded DNA-binding protein HHJ60_02145 ENOG4105ENX hydrolase HHJ60_02185 ENOG4105EQ2 LysR family Transcriptional regulator HHJ60_02190 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HHJ60_02205 ENOG4105CHR reductase HHJ60_02210 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HHJ60_02215 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HHJ60_02220 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) HHJ60_02230 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HHJ60_02235 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HHJ60_02240 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HHJ60_02245 ENOG4105HSA Protein of unknown function (DUF452) HHJ60_02250 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HHJ60_02255 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HHJ60_02270 ENOG4105DJ4 phosphatidylserine decarboxylase HHJ60_02275 ENOG4108V1T peptidylprolyl cis-trans isomerase HHJ60_02285 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HHJ60_02290 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HHJ60_02295 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) HHJ60_02300 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HHJ60_02305 ENOG4105CB5 ATP-dependent DNA helicase recG HHJ60_02310 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HHJ60_02345 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate HHJ60_02350 ENOG4105TWJ Domain of unknown function (DUF1919) HHJ60_02355 ENOG4105P4J Allophanate hydrolase, subunit 1 HHJ60_02360 ENOG4107R7A Allophanate hydrolase subunit 2 HHJ60_02365 ENOG4105E7W lamb ycsf family protein HHJ60_02370 ENOG4105C5A transporter HHJ60_02375 ENOG4105CFP Peptidase U32 HHJ60_02385 ENOG4105SYT Methylenetetrahydrofolate reductase HHJ60_02395 ENOG4105CGK Exodeoxyribonuclease III HHJ60_02410 ENOG4105ERU peptidase HHJ60_02415 ENOG4105C4Y ABC transporter HHJ60_02420 ENOG4107RN3 metallophosphoesterase HHJ60_02425 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HHJ60_02430 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HHJ60_02445 ENOG4105DVT helicase HHJ60_02450 ENOG41072GX Peptidase M22 Glycoprotease HHJ60_02455 ENOG4105CEY Amp-dependent synthetase and ligase HHJ60_02460 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HHJ60_02475 ENOG4108JJ8 (ABC) transporter HHJ60_02480 ENOG4108JJ9 ABC, transporter HHJ60_02485 ENOG4105C3M thioredoxin reductase HHJ60_02490 ENOG4107QR8 Thioredoxin HHJ60_02495 ENOG4105C6Z Gluconate HHJ60_02500 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HHJ60_02505 ENOG4105C5H ABC transporter HHJ60_02510 ENOG4105C8J )-transporter HHJ60_02515 ENOG4105CSM endonuclease III HHJ60_02520 ENOG4105DZB Electron transport complex HHJ60_02525 ENOG4108UQQ Electron transport complex HHJ60_02530 ENOG4105D6A Electron transport complex HHJ60_02535 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HHJ60_02540 ENOG4108R3D Electron transport complex HHJ60_02545 ENOG4105DGN Electron transport complex HHJ60_02550 ENOG4105ECP epimerase HHJ60_02555 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) HHJ60_02560 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HHJ60_02570 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HHJ60_02575 ENOG4105C2X Arabinose 5-phosphate isomerase HHJ60_02585 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HHJ60_02590 ENOG4108DG9 Smr protein MutS2 HHJ60_02595 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HHJ60_02600 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) HHJ60_02605 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HHJ60_02620 ENOG4105VEQ Cold shock protein HHJ60_02635 ENOG4105DIQ Transcriptional regulator HHJ60_02640 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HHJ60_02645 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) HHJ60_02650 ENOG4105DAN ATP-dependent protease HHJ60_02655 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) HHJ60_02660 ENOG4108Z66 YbaK ebsC protein HHJ60_02665 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HHJ60_02670 ENOG4105C7N Xanthine uracil vitamin C permease HHJ60_02675 ENOG41090EX DsrE family HHJ60_02680 ENOG4107QKA exodeoxyribonuclease V beta HHJ60_02685 ENOG4107QYX exodeoxyribonuclease v alpha HHJ60_02695 ENOG4105C5S asparaginyl-tRNA synthetase HHJ60_02700 ENOG4105E2R ROK family HHJ60_02710 ENOG4105CIY formyltetrahydrofolate deformylase HHJ60_02715 ENOG4105CVJ phosphoglycerate mutase HHJ60_02720 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HHJ60_02725 ENOG4108W1A pseudouridine synthase HHJ60_02740 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HHJ60_02745 ENOG4108QBX (LipO)protein HHJ60_02750 ENOG4108NSE outer membrane autotransporter barrel HHJ60_02760 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) HHJ60_02765 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HHJ60_02775 ENOG4108TZV Membrane HHJ60_02780 ENOG4105CJB Exodeoxyribonuclease I HHJ60_02800 ENOG4105KB2 stringent starvation protein b HHJ60_02805 ENOG4107MKT Stringent starvation protein a HHJ60_02820 ENOG4105DR9 pseudouridine synthase HHJ60_02825 ENOG4105WP7 tRNA pseudouridine synthase C HHJ60_02830 ENOG4105EXF Zn-ribbon-containing, possibly nucleic-acid-binding protein HHJ60_02845 ENOG4105EWT decarboxylase family HHJ60_02850 ENOG4105UKP Protein of unknown function (DUF1778) HHJ60_02860 ENOG4105K64 Glycosyl transferase, family 2 HHJ60_02865 ENOG4105E3A (ABC) transporter HHJ60_02870 ENOG4105DA5 (ABC) transporter HHJ60_02875 ENOG4108BPE -transporting atpase HHJ60_02880 ENOG4105D0M Protease HtpX homolog HHJ60_02885 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HHJ60_02890 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HHJ60_02895 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HHJ60_02900 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HHJ60_02905 ENOG4108ESZ Glycogen debranching enzyme HHJ60_02910 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HHJ60_02915 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HHJ60_02920 ENOG4105KAF membrAne HHJ60_02925 ENOG4108ZZ3 UPF0260 protein HHJ60_02930 ENOG4105CX6 glutaminyL-tRNA synthetase HHJ60_02935 ENOG4105DJY efflux transporter, rnd family, mfp subunit HHJ60_02940 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HHJ60_02945 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HHJ60_02955 ENOG4107QN2 dihydrolipoyl dehydrogenase HHJ60_02960 ENOG4107QSN dihydrolipoamide acetyltransferase HHJ60_02965 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HHJ60_02970 ENOG4105C5Y PTS System HHJ60_02975 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HHJ60_02980 ENOG4105KZ7 phosphocarrier protein hpr HHJ60_02985 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HHJ60_02990 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) HHJ60_03005 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HHJ60_03010 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HHJ60_03015 ENOG4105D1H recombination factor protein RarA HHJ60_03030 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) HHJ60_03035 ENOG4105CNU cell division protein FtsK HHJ60_03040 ENOG4105EW9 transcriptional regulator AsnC family HHJ60_03045 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HHJ60_03050 ENOG41067MG lrgb family HHJ60_03055 ENOG4105VAW lrga family HHJ60_03060 ENOG4105KK6 nuclease HHJ60_03065 ENOG4105C9B Cysteine desulfurase HHJ60_03070 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HHJ60_03075 ENOG4105RHG HHJ60_03080 ENOG4105D0Y UPF0227 protein HHJ60_03085 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) HHJ60_03090 ENOG41090BQ Glutaredoxin HHJ60_03095 ENOG4107QZM n-acetylglutamate synthase HHJ60_03110 ENOG4105DJ0 Poly(A) Polymerase HHJ60_03115 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HHJ60_03120 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HHJ60_03130 ENOG4105CTB Polyprenyl synthetase HHJ60_03135 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HHJ60_03140 ENOG4105HBR Rna-binding protein HHJ60_03145 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HHJ60_03150 ENOG4105QVC MOSC domain-containing protein HHJ60_03160 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HHJ60_03165 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HHJ60_03170 ENOG4105DB7 PHP domain protein HHJ60_03175 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) HHJ60_03180 ENOG4105CD8 aminopeptidase N HHJ60_03185 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HHJ60_03230 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HHJ60_03235 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HHJ60_03240 ENOG4105E96 Colicin v production protein HHJ60_03245 ENOG4105PQ6 UPF0208 membrane protein HHJ60_03250 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HHJ60_03255 ENOG4108DNC Involved in acetate metabolism (By similarity) HHJ60_03280 ENOG4105D64 Mechanosensitive ion channel HHJ60_03285 ENOG4108K5H permease YjgP YjgQ family protein HHJ60_03290 ENOG4108M8S permease YjgP YjgQ family protein HHJ60_03295 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HHJ60_03315 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HHJ60_03320 ENOG4105D1A Methyltransferase HHJ60_03325 ENOG4105DDY UPF0142 protein ycaO HHJ60_03330 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HHJ60_03335 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HHJ60_03350 ENOG4105XPH Ferredoxin HHJ60_03360 ENOG4105CCF Lysine exporter protein (Lyse ygga) HHJ60_03365 ENOG4108ZAI phosphatidylglycerophosphatase a HHJ60_03370 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HHJ60_03375 ENOG4107YIM Involved in the transcription termination process (By similarity) HHJ60_03385 ENOG4105E0U tyrosine-specific transport protein HHJ60_03395 ENOG4108BY2 phosphohistidine phosphatase HHJ60_03400 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HHJ60_03405 ENOG4105EEI dihydropteroate synthase HHJ60_03415 ENOG4105C0H protease HHJ60_03420 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HHJ60_03425 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HHJ60_03465 ENOG4105E9S glutaredoxin 2 HHJ60_03505 ENOG4105DFP Integrase HHJ60_03525 ENOG4105W1T Glycosyl Transferase HHJ60_03530 ENOG4105W1T Glycosyl Transferase HHJ60_03550 ENOG4105D7X high-affinity nickel-transporter HHJ60_03555 ENOG41065CD Exported protein HHJ60_03560 ENOG4105C5H ABC transporter HHJ60_03565 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HHJ60_03575 ENOG4105ETE Transcriptional regulator (LacI family HHJ60_03580 ENOG4108RVA ribokinase HHJ60_03585 ENOG4105D9N nucleoside HHJ60_03590 ENOG4105DU0 nucleoside hydrolase HHJ60_03595 ENOG4105C0H protease HHJ60_03600 ENOG4108MN8 Membrane HHJ60_03605 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HHJ60_03615 ENOG4105DIK (ABC) transporter HHJ60_03620 ENOG4105CC5 ABC transporter HHJ60_03625 ENOG4105CC5 ABC transporter HHJ60_03630 ENOG4105DWV Homoserine O-trans-acetylase HHJ60_03635 ENOG4107GZ4 SanA protein HHJ60_03640 ENOG4107B7Y DNA-binding transcriptional regulator FruR HHJ60_03645 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HHJ60_03650 ENOG4105D60 lipoprotein releasing system transmembrane protein HHJ60_03655 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HHJ60_03660 ENOG4105D60 lipoprotein releasing system transmembrane protein HHJ60_03665 ENOG4105C5I Dehydrogenase HHJ60_03670 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HHJ60_03675 ENOG41063JG Transcriptional regulator HHJ60_03680 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HHJ60_03685 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HHJ60_03695 ENOG4105EM2 membrane HHJ60_03700 ENOG4108Z5K methylglyoxal synthase HHJ60_03710 ENOG4108ZAF Molybdopterin HHJ60_03715 ENOG4105M00 molybdopterin converting factor, subunit 1 HHJ60_03720 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HHJ60_03725 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HHJ60_03765 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HHJ60_03770 ENOG4105EUJ GTP cyclohydrolase i HHJ60_03775 ENOG4105CVM Molybdenum cofactor synthesis domain protein HHJ60_03780 ENOG4105D06 uba thif-type nad fad binding protein HHJ60_03785 ENOG4105DWU Membrane HHJ60_03790 ENOG41090A1 ferritin HHJ60_03795 ENOG41090A1 ferritin HHJ60_03805 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HHJ60_03810 ENOG4105Q9Y Universal stress protein HHJ60_03820 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) HHJ60_03825 ENOG4107R11 Transcriptional regulator HHJ60_03830 ENOG4105FE9 pseudouridine synthase HHJ60_03835 ENOG4107RTD sua5 ycio yrdc ywlc family protein HHJ60_03840 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HHJ60_03845 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HHJ60_03850 ENOG41082RQ UPF0102 protein HHJ60_03855 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) HHJ60_03860 ENOG4105W4M Transport-associated protein HHJ60_03865 ENOG4105C4R Atp-dependent dna helicase HHJ60_03880 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) HHJ60_03885 ENOG4105ETT transcriptional Regulator, LysR family HHJ60_03890 ENOG4105CM2 brancheD-chain amino acid aminotransferase HHJ60_03910 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HHJ60_03915 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HHJ60_03920 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HHJ60_03925 ENOG4105C28 cystathionine HHJ60_03930 ENOG4105D3R alkyl hydroperoxide reductase HHJ60_03940 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HHJ60_03945 ENOG4105D1S lipid A biosynthesis HHJ60_03950 ENOG4105C5X domain protein HHJ60_03960 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HHJ60_03965 ENOG4105CN1 protease HHJ60_03970 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HHJ60_03975 ENOG4105H2K paraquat-inducible protein a HHJ60_03980 ENOG4105DY2 Paraquat-inducible protein b HHJ60_03985 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HHJ60_03990 ENOG4105CEI nitrite reductase HHJ60_03995 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HHJ60_04000 ENOG4105G0K glycine radical enzyme YjjI family HHJ60_04005 ENOG41076CZ activating enzyme HHJ60_04010 ENOG4106B0W Curli production assembly transport component CsgG HHJ60_04020 ENOG4107Y60 (LipO)protein HHJ60_04025 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HHJ60_04030 ENOG4105CC0 LysR family Transcriptional regulator HHJ60_04035 ENOG4105D07 Signal peptide peptidase, SppA HHJ60_04040 ENOG41069NU Nitroreductase HHJ60_04045 ENOG4105EUB pirin domain protein HHJ60_04060 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HHJ60_04065 ENOG4108ZP8 Acetolactate synthase small subunit HHJ60_04070 ENOG4105C7K acetolactate synthase HHJ60_04075 ENOG4107S6Z Na H antiporter HHJ60_04080 ENOG4108YX2 DNA-binding protein HHJ60_04090 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HHJ60_04095 ENOG4107QNR UPF0135 protein HHJ60_04100 ENOG4105ETE Transcriptional regulator (LacI family HHJ60_04115 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HHJ60_04140 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HHJ60_04145 ENOG41087AY ADP-Ribose pyrophosphatase HHJ60_04150 ENOG4108VY7 phosphate-starvation-inducible protein PsiE HHJ60_04160 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) HHJ60_04165 ENOG4105KUZ arsenate reductase HHJ60_04170 ENOG4105DVP Adenine-specific HHJ60_04175 ENOG4106NNP ICEA Protein HHJ60_04185 ENOG4105D98 threonine synthase HHJ60_04190 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HHJ60_04195 ENOG4105CFH Aspartokinase HHJ60_04205 ENOG4105DFA alanine racemase domain protein HHJ60_04210 ENOG4108UYE Lactoylglutathione lyase HHJ60_04215 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HHJ60_04220 ENOG4105D3Y Na H antiporter HHJ60_04225 ENOG4105C26 Dehydrogenase HHJ60_04230 ENOG4105CK7 Sodium proline symporter HHJ60_04235 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HHJ60_04240 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HHJ60_04245 ENOG4105NSG hemerythrin hhe cation binding domain protein HHJ60_04250 ENOG4105VIE preprotein translocase, subunit YajC HHJ60_04255 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HHJ60_04260 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HHJ60_04265 ENOG4107SC1 transglycosylase HHJ60_04270 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) HHJ60_04275 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase HHJ60_04280 ENOG4105EMU Dehydrogenase HHJ60_04285 ENOG4105D8G Major Facilitator superfamily HHJ60_04310 ENOG4105CKT filamentous hemagglutinin HHJ60_04335 ENOG4107QMH DNA methylase HHJ60_04345 ENOG4105EJC lysr family transcriptional regulator HHJ60_04350 ENOG4105DHQ Histidine kinase HHJ60_04355 ENOG4105XJC Two component transcriptional regulator (Winged helix family HHJ60_04360 ENOG4105ETU transcriptional activator (TenA HHJ60_04370 ENOG4105EXC Acyl-transferase HHJ60_04380 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HHJ60_04385 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HHJ60_04390 ENOG4105PW4 Sugar fermentation stimulation protein homolog HHJ60_04400 ENOG4106KS4 Sulfatase HHJ60_04410 ENOG4105D2T synthase HHJ60_04425 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HHJ60_04430 ENOG4105D7K pfkb domain protein HHJ60_04450 ENOG4105K8N protein family UPF0079, ATPase HHJ60_04455 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HHJ60_04460 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HHJ60_04470 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HHJ60_04475 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HHJ60_04485 ENOG4105XW2 UPF0263 protein HHJ60_04500 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HHJ60_04510 ENOG4108QDQ Ubiquinol-cytochrome C chaperone HHJ60_04545 ENOG4105D29 Helix-turn-helix type 11 domain protein HHJ60_04560 ENOG4105C2I pirin domain protein HHJ60_04565 ENOG4105CVE Lytic murein transglycosylase HHJ60_04570 ENOG4108RYC glycosyltransferase HHJ60_04575 ENOG4108RJ9 Glycosyl transferase, family 2 HHJ60_04585 ENOG41068D6 Glycosyltransferase HHJ60_04595 ENOG4108ZPC Polysaccharide pyruvyl transferase HHJ60_04600 ENOG41080C8 DUF218 domain HHJ60_04605 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HHJ60_04610 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HHJ60_04615 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HHJ60_04620 ENOG4105D1F ATP-binding protein HHJ60_04625 ENOG4107SJW iron permease, FTR1 HHJ60_04640 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HHJ60_04650 ENOG4105C19 ABC transporter HHJ60_04655 ENOG4105DSB aldose 1-epimerase HHJ60_04665 ENOG4105CRK lysyL-tRNA synthetase HHJ60_04680 ENOG4105T95 Thiol disulfide interChange protein HHJ60_04685 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HHJ60_04690 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) HHJ60_04695 ENOG4105UYK outer membrane protein a HHJ60_04700 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HHJ60_04705 ENOG4108UUE Transcriptional regulator HHJ60_04710 ENOG4105E0A ABC, transporter HHJ60_04720 ENOG4105S6R Iron-hydroxamate transporter permease subunit HHJ60_04735 ENOG4105E0K tonB-dependent siderophore receptor HHJ60_04740 ENOG4105E0K tonB-dependent siderophore receptor HHJ60_04750 ENOG4105C44 Serine transporter HHJ60_04755 ENOG4105WWK YheO domain protein HHJ60_04765 ENOG4105CA9 Pyruvate kinase HHJ60_04770 ENOG4108RCM Nitroreductase HHJ60_04775 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HHJ60_04780 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HHJ60_04785 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HHJ60_04795 ENOG4105C7S Dehydrogenase HHJ60_04800 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HHJ60_04805 ENOG4105BZN citrate synthase HHJ60_04810 ENOG4107XHZ cytoplasmic chaperone TorD family protein HHJ60_04815 ENOG4105DYS nad(p)h dehydrogenase (quinone) HHJ60_04825 ENOG4107QX8 SPFH domain, Band 7 family protein HHJ60_04830 ENOG4105K3M )-transporter HHJ60_04850 ENOG4105E2R ROK family HHJ60_04860 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HHJ60_04865 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HHJ60_04870 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HHJ60_04875 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) HHJ60_04885 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HHJ60_04890 ENOG4105C8Y Acetylornithine aminotransferase HHJ60_04895 ENOG4105D1U peptidase U62 modulator of DNA gyrase HHJ60_04900 ENOG4105C03 ribonuclease HHJ60_04955 ENOG4105ESV Glycosyl transferase, family 4 HHJ60_04960 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HHJ60_04965 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HHJ60_04970 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HHJ60_04975 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HHJ60_04980 ENOG4108ZIG UPF0231 protein HHJ60_04985 ENOG4105BZ4 penicillin-binding protein HHJ60_04995 ENOG4107TSG Extracellular solute-binding protein, family 5 HHJ60_05000 ENOG4105WD1 Membrane HHJ60_05005 ENOG4105DGW oligopeptidase A HHJ60_05015 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HHJ60_05020 ENOG4105E33 succinate dehydrogenase HHJ60_05025 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HHJ60_05030 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) HHJ60_05035 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HHJ60_05040 ENOG4105NXV High-affinity zinc uptake system protein HHJ60_05045 ENOG4105CUZ uba thif-type nad fad binding protein HHJ60_05050 ENOG4105CA3 membrane-bound lytic murein transglycosylase HHJ60_05065 ENOG4105VEQ Cold shock protein HHJ60_05070 ENOG4105DFU Cell wall formation (By similarity) HHJ60_05080 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HHJ60_05085 ENOG4105VFK BolA family HHJ60_05095 ENOG4105E3I toluene tolerance HHJ60_05100 ENOG4107PE3 Mammalian cell entry related domain protein HHJ60_05105 ENOG4105CY3 ABC transporter, permease HHJ60_05110 ENOG4105DHJ ABC, transporter HHJ60_05120 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HHJ60_05125 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HHJ60_05130 ENOG4108IUZ ABC transporter HHJ60_05135 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HHJ60_05150 ENOG4107YCY Transcriptional regulator HHJ60_05160 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HHJ60_05165 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HHJ60_05175 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HHJ60_05180 ENOG4105DMW Dehydrogenase reductase HHJ60_05205 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HHJ60_05210 ENOG41090HJ UPF0265 protein HHJ60_05220 ENOG4105C5Y PTS System HHJ60_05225 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HHJ60_05230 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HHJ60_05235 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HHJ60_05240 ENOG4105E4F Isochorismate synthase HHJ60_05245 ENOG4105CHM Aminotransferase HHJ60_05255 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HHJ60_05260 ENOG41080I0 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HHJ60_05265 ENOG4105EE5 Membrane protein terC HHJ60_05275 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HHJ60_05280 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HHJ60_05295 ENOG4105EN6 Membrane HHJ60_05300 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HHJ60_05305 ENOG4105CFH Aspartokinase HHJ60_05310 ENOG4107RM6 sulfurtransferase HHJ60_05315 ENOG4105CUC YeeE YedE family protein HHJ60_05320 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HHJ60_05335 ENOG4105D2M Aldolase HHJ60_05340 ENOG4105CE4 GlcNAc 6-P deacetylase HHJ60_05345 ENOG4105E98 transcriptional regulator DeoR family HHJ60_05355 ENOG4105ENH Sulfatase HHJ60_05360 ENOG4105C4X radical SAM domain protein HHJ60_05375 ENOG4105DAS pts system HHJ60_05380 ENOG4105F3R pts system mannose fructose sorbose family iid HHJ60_05385 ENOG4105ETZ PTS System HHJ60_05390 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HHJ60_05395 ENOG4105E70 isomerase HHJ60_05400 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HHJ60_05405 ENOG4105CBG Sulfatase HHJ60_05415 ENOG4105CHR reductase HHJ60_05425 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HHJ60_05430 ENOG4108UHU Aldolase HHJ60_05435 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HHJ60_05440 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HHJ60_05450 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HHJ60_05470 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HHJ60_05475 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HHJ60_05480 ENOG4108UBT opacity-associated protein HHJ60_05485 ENOG4105DH7 May be involved in recombination (By similarity) HHJ60_05490 ENOG4105II7 pyrroline-5-carboxylate reductase HHJ60_05495 ENOG4105D8G Major Facilitator superfamily HHJ60_05500 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HHJ60_05505 ENOG4105CQC Prephenate dehydratase HHJ60_05525 ENOG4105EMU Dehydrogenase HHJ60_05540 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HHJ60_05545 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HHJ60_05550 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HHJ60_05555 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HHJ60_05560 ENOG4105CPF Cell wall formation (By similarity) HHJ60_05565 ENOG4105DFU Cell wall formation (By similarity) HHJ60_05570 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HHJ60_05575 ENOG4105CNI cell division protein FtsW HHJ60_05580 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HHJ60_05585 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HHJ60_05590 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HHJ60_05595 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HHJ60_05600 ENOG4105CJN penicillin-binding protein HHJ60_05610 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HHJ60_05615 ENOG4108V6E Cell division protein mraZ HHJ60_05635 ENOG4105C9A Phoh family HHJ60_05645 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HHJ60_05650 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HHJ60_05655 ENOG4105E7A Glutamine amidotransferase HHJ60_05660 ENOG4105C44 Serine transporter HHJ60_05665 ENOG4105EJQ L-serine dehydratase HHJ60_05670 ENOG4105DA4 cytochrome c-type biogenesis protein HHJ60_05675 ENOG4107QX9 Thiol disulfide interChange protein HHJ60_05680 ENOG4108DMF Cytochrome C biogenesis protein HHJ60_05685 ENOG4108DMF Cytochrome C biogenesis protein HHJ60_05690 ENOG4105CBX hi0933 family HHJ60_05695 ENOG4105C0B DNA polymerase III (alpha subunit) HHJ60_05700 ENOG4105DVI reductase, NrfD HHJ60_05705 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HHJ60_05710 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HHJ60_05715 ENOG4105EAU Plays a role in nitrite reduction (By similarity) HHJ60_05720 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HHJ60_05735 ENOG4105DZ1 carboxypeptidase HHJ60_05740 ENOG4105K6T rare lipoprotein A HHJ60_05745 ENOG4105CNI cell division protein FtsW HHJ60_05750 ENOG4105CJN penicillin-binding protein HHJ60_05760 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HHJ60_05765 ENOG4105C1J atp-dependent rna helicase HHJ60_05770 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HHJ60_05775 ENOG4105F27 Major Facilitator HHJ60_05785 ENOG4105DHP deoxycytidine triphosphate deaminase HHJ60_05795 ENOG4107RCV ABC transporter, permease HHJ60_05800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HHJ60_05825 ENOG4105M2J Glutaredoxin HHJ60_05840 ENOG4108V0P LemA family HHJ60_05850 ENOG4105CQB FAD linked oxidase domain protein HHJ60_05855 ENOG4105KA0 thioesterase Superfamily protein HHJ60_05865 ENOG4105EIF outer membrane protein W HHJ60_05880 ENOG4105NAU thioesterase Superfamily protein HHJ60_05885 ENOG4105K9H YciI-like protein HHJ60_05890 ENOG4107QIJ Aconitate hydratase 2 HHJ60_05905 ENOG4105EFX secretion protein, HlyD family HHJ60_05910 ENOG4105KK7 inner membrane protein YiaW HHJ60_05915 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HHJ60_05920 ENOG4105CHV Transcription elongation factor NusA HHJ60_05925 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HHJ60_05935 ENOG4105XTM Inherit from NOG: Mn2 dependent serine threonine protein kinase HHJ60_05940 ENOG4105BZG amino acid carrier protein HHJ60_05955 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HHJ60_05960 ENOG4105EYK Phosphatidylglycerophosphatase B HHJ60_05980 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HHJ60_05990 ENOG4108R6K riboflavin synthase, subunit alpha HHJ60_05995 ENOG4107QI1 Mate efflux family protein HHJ60_06000 ENOG4105D9R oxidoreductase HHJ60_06005 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HHJ60_06010 ENOG4108VD1 dedA family HHJ60_06015 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HHJ60_06020 ENOG4108YI8 ABC transporter HHJ60_06025 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component HHJ60_06030 ENOG4107Z6I Thiamine biosynthesis protein HHJ60_06035 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HHJ60_06040 ENOG41085JB UPF0434 protein HHJ60_06045 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HHJ60_06050 ENOG4105BZ1 (ABC) transporter HHJ60_06055 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HHJ60_06060 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HHJ60_06065 ENOG4105DWF phosphomethylpyrimidine kinase HHJ60_06070 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HHJ60_06075 ENOG4105K3M )-transporter HHJ60_06080 ENOG4108BMY protease HHJ60_06085 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HHJ60_06090 ENOG4105I7R Adenylate cyclase HHJ60_06095 ENOG4107IX6 phosphate transport regulator HHJ60_06100 ENOG4105CJ3 phosphate transporter HHJ60_06105 ENOG41077A9 carbonic anhydrase HHJ60_06110 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HHJ60_06115 ENOG4105CGF Aromatic amino acid aminotransferase HHJ60_06120 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HHJ60_06125 ENOG4107VHA regulatoR HHJ60_06130 ENOG4105C6Z Gluconate HHJ60_06135 ENOG4105BZW Glycerate kinase HHJ60_06160 ENOG4108TIT dATP pyrophosphohydrolase HHJ60_06225 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HHJ60_06230 ENOG4105CDU Replicative dna helicase HHJ60_06235 ENOG4105NBI YecM protein HHJ60_06245 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HHJ60_06250 ENOG4105E0C molybdate abc transporter HHJ60_06255 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HHJ60_06260 ENOG4105F4R Transcriptional regulator mode HHJ60_06265 ENOG4105D6U Sodium Glutamate Symporter HHJ60_06290 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HHJ60_06295 ENOG4107T0D ABC, transporter HHJ60_06300 ENOG4106SMU thiamine transporter membrane protein HHJ60_06305 ENOG4105DP9 ABC transporter HHJ60_06310 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HHJ60_06315 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HHJ60_06320 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HHJ60_06325 ENOG4105F38 ABC transporter, permease HHJ60_06330 ENOG4105D38 putrescine abc transporter HHJ60_06335 ENOG4107RUE extracellular solute-binding protein family 1 HHJ60_06345 ENOG4105KVH Transcriptional regulator HHJ60_06350 ENOG4105C6K Malic enzyme HHJ60_06360 ENOG4105CK5 oxidoreductase HHJ60_06370 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HHJ60_06385 ENOG4107EJG GntR family transcriptional regulator HHJ60_06390 ENOG4105CK5 oxidoreductase HHJ60_06400 ENOG4107QMP dna polymerase iii subunits gamma and tau HHJ60_06405 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HHJ60_06410 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HHJ60_06415 ENOG4105EJ9 Membrane HHJ60_06420 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HHJ60_06430 ENOG4105EGS Mechanosensitive ion channel HHJ60_06435 ENOG4105CEY Amp-dependent synthetase and ligase HHJ60_06440 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HHJ60_06445 ENOG4105EV9 Alpha Beta Hydrolase HHJ60_06450 ENOG4105NNH LexA regulated protein HHJ60_06455 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HHJ60_06460 ENOG41090R7 Ferric uptake HHJ60_06465 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HHJ60_06470 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HHJ60_06490 ENOG4105EMU Dehydrogenase HHJ60_06515 ENOG4105C2C drug resistance transporter, Bcr CflA HHJ60_06530 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HHJ60_06535 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HHJ60_06540 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HHJ60_06565 ENOG4107YB6 acetyltransferase, (GNAT) family HHJ60_06570 ENOG4105MYG DNA polymerase iii, chi subunit HHJ60_06575 ENOG4105C9Q fumarate hydratase class II HHJ60_06580 ENOG4105CRQ synthase (Component I) HHJ60_06585 ENOG4105DDQ anthranilate synthase HHJ60_06590 ENOG4108V5Q transglutaminase-like protein HHJ60_06595 ENOG4107QYG anthranilate phosphoribosyltransferase HHJ60_06600 ENOG4105DK0 Indole-3-glycerol phosphate synthase HHJ60_06615 ENOG4105KWI UPF0339 protein HHJ60_06625 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HHJ60_06630 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HHJ60_06645 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HHJ60_06650 ENOG4105DFP Integrase HHJ60_06685 ENOG4106050 phage regulatory protein, rha family HHJ60_06710 ENOG4105NVB glycoside hydrolase, family 19 HHJ60_06735 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HHJ60_06895 ENOG4106CVF DNA replication protein HHJ60_06920 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HHJ60_06940 ENOG4107EPN Domain of unknown function (DUF1508) HHJ60_06990 ENOG4108UUM single-stranded DNA-binding protein HHJ60_07005 ENOG4105DH7 May be involved in recombination (By similarity) HHJ60_07050 ENOG4105NI8 Cytosine-specific methyltransferase HHJ60_07070 ENOG4108VTV Inherit from NOG: Membrane HHJ60_07075 ENOG4105M4H endoribonuclease L-psp HHJ60_07085 ENOG4105EEQ Na H antiporter HHJ60_07090 ENOG4105C42 Type I secretion membrane fusion protein (HlyD HHJ60_07160 ENOG4105CXN decarboxylase HHJ60_07165 ENOG4105D5Q Arginine ornithine antiporter HHJ60_07175 ENOG4105C59 p-type ATPase HHJ60_07185 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HHJ60_07195 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HHJ60_07200 ENOG4108MG3 formate dehydrogenase HHJ60_07205 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HHJ60_07215 ENOG4105UGU tonB-dependent Receptor HHJ60_07220 ENOG4105KMT branched-chain amino acid HHJ60_07225 ENOG4108UMN azlc family HHJ60_07230 ENOG4105DZ2 Transcriptional regulator HHJ60_07235 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HHJ60_07240 ENOG4105C8P )-transporter HHJ60_07250 ENOG4105CQ7 ATP-dependent helicase HHJ60_07255 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HHJ60_07260 ENOG41082NX 50s ribosomal protein l35 HHJ60_07265 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HHJ60_07270 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HHJ60_07280 ENOG4105FAV ABC, transporter HHJ60_07285 ENOG4105FDK ABC transporter HHJ60_07290 ENOG4105DR5 peptidase HHJ60_07295 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HHJ60_07300 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HHJ60_07310 ENOG4105EZE Cupin 4 family protein HHJ60_07315 ENOG4105VDB UPF0125 protein HHJ60_07320 ENOG4108Z1B Cyclase dehydrase HHJ60_07325 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HHJ60_07330 ENOG4105C3G gtp-binding protein HHJ60_07340 ENOG4105D5Q Arginine ornithine antiporter HHJ60_07345 ENOG4108JU8 Transcriptional regulator HHJ60_07350 ENOG4106K28 UPF0283 membrane protein HHJ60_07355 ENOG4105CM6 amino acid regulated cytosolic protein HHJ60_07360 ENOG4108EVY peptide transport periplasmic protein HHJ60_07370 ENOG4108EU3 peptide transport system, permease HHJ60_07375 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HHJ60_07385 ENOG4105YK5 50S ribosomal protein L36 HHJ60_07390 ENOG4105NRA 50s ribosomal protein l31 type b HHJ60_07405 ENOG4105MGM doxx family HHJ60_07410 ENOG4105DC1 bifunctional purine biosynthesis protein purh HHJ60_07420 ENOG4105C12 Phosphoribosylglycinamide synthetase HHJ60_07425 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HHJ60_07430 ENOG41065U4 response regulator HHJ60_07440 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HHJ60_07445 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HHJ60_07450 ENOG4108ZJT translation initiation factor, Sui1 HHJ60_07460 ENOG4105CFV Tetratricopeptide repeat protein HHJ60_07465 ENOG4105Q4A inner membrane protein yciS HHJ60_07470 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) HHJ60_07475 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HHJ60_07480 ENOG4105CAT Cytidine monophosphate kinase HHJ60_07490 ENOG4107RAN Peptidase, M16 HHJ60_07495 ENOG4108MJ5 VirK protein HHJ60_07500 ENOG4105CDH Citrulline--aspartate ligase HHJ60_07505 ENOG4107SRH Nad-dependent epimerase dehydratase HHJ60_07520 ENOG4105C8V SAICAR synthetase HHJ60_07525 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) HHJ60_07530 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HHJ60_07535 ENOG4105CE9 30S ribosomal protein S2 HHJ60_07540 ENOG4105EIN peptidylprolyl cis-trans isomerase HHJ60_07545 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HHJ60_07550 ENOG4105DC8 reductase HHJ60_07555 ENOG4105D6S protein involved in catabolism of external DNA HHJ60_07560 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HHJ60_07565 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HHJ60_07570 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HHJ60_07575 ENOG4105C0A alcohol dehydrogenase HHJ60_07580 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HHJ60_07585 ENOG4105E55 glycerol-3-phosphate acyltransferase HHJ60_07590 ENOG41065S8 Opacity family porin protein HHJ60_07600 ENOG4105CQ0 ABC transporter HHJ60_07605 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HHJ60_07615 ENOG4105E7U AraC family transcriptional regulator HHJ60_07625 ENOG4105BZG amino acid carrier protein HHJ60_07645 ENOG4105D7Q type ii secretion system HHJ60_07650 ENOG4105DAS pts system HHJ60_07655 ENOG4105ETZ PTS System HHJ60_07660 ENOG4105F3R pts system mannose fructose sorbose family iid HHJ60_07665 ENOG4108NK4 UPF0266 membrane protein HHJ60_07670 ENOG4105EIP mannose-6-phosphate isomerase HHJ60_07675 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HHJ60_07680 ENOG4107RZZ dna polymerase iii epsilon subunit HHJ60_07695 ENOG4105CXB phosphoribosylaminoimidazole synthetase HHJ60_07700 ENOG4108V3E phosphoribosylglycinamide formyltransferase HHJ60_07705 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HHJ60_07710 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HHJ60_07720 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HHJ60_07725 ENOG4105WV0 Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) HHJ60_07730 ENOG4105C8T Leucyl-tRNA synthetase HHJ60_07740 ENOG4105DJF DNA polymerase III, delta' subunit HHJ60_07750 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HHJ60_07760 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HHJ60_07765 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HHJ60_07770 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HHJ60_07780 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HHJ60_07785 ENOG4105DZP Membrane-associated zinc metalloprotease HHJ60_07790 ENOG4105KNE Phosphatidate cytidylyltransferase HHJ60_07795 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HHJ60_07800 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HHJ60_07805 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HHJ60_07810 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) HHJ60_07815 ENOG4107QHF type ii secretion system protein e HHJ60_07825 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HHJ60_07835 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) HHJ60_07840 ENOG4105HF0 Membrane HHJ60_07845 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HHJ60_07855 ENOG4108Z6B deaminase HHJ60_07860 ENOG4105CE4 GlcNAc 6-P deacetylase HHJ60_07865 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HHJ60_07880 ENOG41084CK capsule polysaccharide HHJ60_07885 ENOG4105E12 capsule polysaccharide HHJ60_07940 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HHJ60_07945 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HHJ60_07950 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HHJ60_07955 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HHJ60_08020 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HHJ60_08105 ENOG4108N0N Phage Terminase Large Subunit HHJ60_08110 ENOG41061CV Terminase small subunit HHJ60_08160 ENOG4105WXW Antirepressor HHJ60_08165 ENOG4105NY2 NinB protein HHJ60_08245 ENOG41061CV Terminase small subunit HHJ60_08250 ENOG4108N0N Phage Terminase Large Subunit HHJ60_08255 ENOG4107ZQ5 Phage-associated protein, HI1409 family HHJ60_08260 ENOG4108C66 Inherit from COG: DNA primase HHJ60_08270 ENOG41090AG Bacteriophage protein HHJ60_08315 ENOG4106GZK Protein of unknown function (DUF2669) HHJ60_08415 ENOG4105CWC Acetylornithine deacetylase HHJ60_08420 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HHJ60_08425 ENOG4105CAS nag kinase HHJ60_08430 ENOG4105CH7 arginosuccinase HHJ60_08445 ENOG4105DHQ Histidine kinase HHJ60_08450 ENOG4105XJC Two component transcriptional regulator (Winged helix family HHJ60_08460 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HHJ60_08470 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HHJ60_08475 ENOG4105DTN riboflavin biosynthesis protein ribF HHJ60_08490 ENOG4108RMU ferritin dps family protein HHJ60_08495 ENOG4105DDQ anthranilate synthase HHJ60_08500 ENOG4105CRQ synthase (Component I) HHJ60_08525 ENOG4105KME endoribonuclease L-psp HHJ60_08535 ENOG4105DJV ribulose-phosphate 3-epimerase HHJ60_08540 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HHJ60_08545 ENOG4105C31 Tryptophanyl-tRNA synthetase HHJ60_08550 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HHJ60_08560 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) HHJ60_08565 ENOG4105E98 transcriptional regulator DeoR family HHJ60_08570 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HHJ60_08575 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HHJ60_08580 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HHJ60_08585 ENOG4105CXY transporter HHJ60_08590 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HHJ60_08595 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HHJ60_08600 ENOG4106H78 methyltransferase HHJ60_08605 ENOG4105C79 DNA protecting protein DprA HHJ60_08610 ENOG41090FY type IV pilus biogenesis stability protein PilW HHJ60_08620 ENOG4105DSF transport protein HHJ60_08625 ENOG4108YZA Nitrogen regulatory protein pii HHJ60_08630 ENOG4108RIR Molybdenum cofactor biosynthesis protein HHJ60_08635 ENOG4108HPI phosphatidate Cytidylyltransferase HHJ60_08645 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HHJ60_08650 ENOG4107QWE )-transporter HHJ60_08655 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) HHJ60_08660 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HHJ60_08665 ENOG4105CUT histidyl-tRNA synthetase HHJ60_08670 ENOG4105N21 Membrane HHJ60_08675 ENOG4105PF3 O-Antigen polymerase HHJ60_08690 ENOG4105C30 Nad-dependent epimerase dehydratase HHJ60_08710 ENOG4105CMS peptidase U62, modulator of DNA gyrase HHJ60_08715 ENOG4108UGV hypoxanthine phosphoribosyltransferase HHJ60_08725 ENOG4105C4M (Ubiquinol oxidase) subunit I HHJ60_08730 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HHJ60_08740 ENOG4105KJB cyd operon protein YbgE HHJ60_08750 ENOG4107YD3 Thioesterase HHJ60_08755 ENOG4105E02 MotA TolQ exbB proton channel HHJ60_08775 ENOG4105KCK Peptidoglycan-associated lipoprotein HHJ60_08810 ENOG4105DSY exodeoxyribonuclease V, gamma HHJ60_08815 ENOG4108K4B hydrolase HHJ60_08820 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HHJ60_08825 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HHJ60_08860 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) HHJ60_08865 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HHJ60_08870 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HHJ60_08920 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HHJ60_08925 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HHJ60_08930 ENOG4108UMI ABC transporter, permease HHJ60_08935 ENOG4105D01 (LipO)protein HHJ60_08940 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HHJ60_08945 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HHJ60_08950 ENOG4105CWM branched-chain amino acid transport system II carrier protein HHJ60_08955 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HHJ60_08965 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HHJ60_08975 ENOG4108M6U Universal stress protein A HHJ60_08980 ENOG4105DXN mazG family HHJ60_08985 ENOG4105DTR rard protein HHJ60_08990 ENOG4105EMY transcriptional regulator HHJ60_08995 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HHJ60_09000 ENOG4105CBG Sulfatase HHJ60_09010 ENOG4105CK7 Sodium proline symporter HHJ60_09015 ENOG4105C5H ABC transporter HHJ60_09020 ENOG4106AFN Lyase and sodium transporter (By similarity) HHJ60_09025 ENOG4107QSA Oxaloacetate decarboxylase HHJ60_09030 ENOG4105D9Q decarboxylase (Beta subunit) HHJ60_09045 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HHJ60_09055 ENOG4105C9U ATP-dependent DNA helicase RecQ HHJ60_09080 ENOG4105CIN aminoacyl-histidine dipeptidase HHJ60_09090 ENOG4107QMH DNA methylase HHJ60_09100 ENOG4108YYD acetyltransferase HHJ60_09115 ENOG4105PGM cation diffusion facilitator family transporter HHJ60_09150 ENOG4105CXY transporter HHJ60_09155 ENOG4105ECY inositol monophosphatase HHJ60_09160 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HHJ60_09165 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HHJ60_09170 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HHJ60_09175 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HHJ60_09180 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) HHJ60_09205 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HHJ60_09210 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HHJ60_09215 ENOG4105QTB Flavodoxin HHJ60_09225 ENOG4105CBT Fructose-1,6-bisphosphatase HHJ60_09230 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HHJ60_09240 ENOG4108JJ9 ABC, transporter HHJ60_09245 ENOG4105BZ1 (ABC) transporter HHJ60_09250 ENOG4105CA0 peroxidase HHJ60_09260 ENOG4105C8J )-transporter HHJ60_09265 ENOG4105E2X shikimate dehydrogenase HHJ60_09270 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HHJ60_09275 ENOG4108WI1 Dna topoisomerase HHJ60_09280 ENOG4108Z03 MAF-like protein HHJ60_09285 ENOG4105CGY Dna recombination protein HHJ60_09290 ENOG4108TEB UPF0114 protein HHJ60_09325 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HHJ60_09335 ENOG4105T16 Transcriptional regulator (AraC family) HHJ60_09340 ENOG4105CMG Carbohydrate kinase HHJ60_09345 ENOG4105C93 Xylose Isomerase HHJ60_09350 ENOG4105CHM Aminotransferase HHJ60_09355 ENOG4105DFD Na H antiporter HHJ60_09360 ENOG4107QTF adenylosuccinate lyase HHJ60_09365 ENOG41075W9 High frequency lysogenization protein HflD homolog HHJ60_09375 ENOG410804X Transcriptional regulator HHJ60_09380 ENOG4105J92 DNA-binding transcriptional activator GutM HHJ60_09385 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HHJ60_09390 ENOG4105VI0 Pts system, glucitol sorbitol-specific HHJ60_09395 ENOG4105DZY Pts system, glucitol sorbitol-specific HHJ60_09400 ENOG410787A Pts system, glucitol sorbitol-specific HHJ60_09405 ENOG4105CKD glutathione-regulated potassium-efflux system protein HHJ60_09410 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HHJ60_09415 ENOG4108UJU UPF0301 protein HHJ60_09425 ENOG4108HWW ABC transporter HHJ60_09430 ENOG4105C2J ABC transporter HHJ60_09435 ENOG4105DFW ABC transporter HHJ60_09440 ENOG4105CEN a g-specific adenine glycosylase HHJ60_09445 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) HHJ60_09450 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HHJ60_09465 ENOG4107QUT magnesium and cobalt transport protein CorA HHJ60_09470 ENOG4108VIA integral membrane protein HHJ60_09475 ENOG4105VZ9 UPF0235 protein HHJ60_09480 ENOG4105CRP Part of the ABC transporter FtsEX involved in HHJ60_09485 ENOG4105CAK Cell division ATP-binding protein ftsE HHJ60_09490 ENOG4105CV1 Transketolase (EC 2.2.1.1) HHJ60_09495 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HHJ60_09500 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HHJ60_09505 ENOG4105CMG Carbohydrate kinase HHJ60_09510 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HHJ60_09515 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HHJ60_09520 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HHJ60_09525 ENOG4108R66 Conserved Protein HHJ60_09530 ENOG4105DG4 malate L-lactate dehydrogenase HHJ60_09535 ENOG41069M3 Transcriptional regulator HHJ60_09540 ENOG4105K5B UPF0225 protein HHJ60_09545 ENOG4107S2Z UPF0761 membrane protein HHJ60_09555 ENOG4105WH1 Two component transcriptional regulator luxr family HHJ60_09560 ENOG4107T0K Adenylate cyclase HHJ60_09565 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HHJ60_09575 ENOG4105ECF c-methyltransferase HHJ60_09580 ENOG410601J HemY protein HHJ60_09585 ENOG4108ZPB UPF0306 protein HHJ60_09590 ENOG4108JPW Aminotransferase HHJ60_09595 ENOG4105DY8 decarboxylase HHJ60_09600 ENOG4105C0P Mg chelatase subunit ChlI HHJ60_09605 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HHJ60_09610 ENOG41090ED Protein with unknown function (DUF469) HHJ60_09615 ENOG4105C1Y Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) HHJ60_09620 ENOG4105EM7 Selenocysteine-specific translation elongation factor HHJ60_09625 ENOG4105EI2 Pseudouridine synthase HHJ60_09630 ENOG4105C03 ribonuclease HHJ60_09640 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) HHJ60_09645 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HHJ60_09650 ENOG4108IPT Naphthoate synthase HHJ60_09660 ENOG4105DNI Converts SHCHC to OSB (By similarity) HHJ60_09670 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HHJ60_09675 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HHJ60_09680 ENOG4105RG0 Membrane HHJ60_09685 ENOG4108IA2 Sodium pantothenate symporter HHJ60_09695 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HHJ60_09700 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) HHJ60_09705 ENOG4108HMX isocitrate dehydrogenase (NADP) HHJ60_09710 ENOG4108R99 pseudouridine synthase HHJ60_09720 ENOG4105R3P Inner membrane protein yagU HHJ60_09725 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HHJ60_09730 ENOG4108R3E Dna-3-methyladenine glycosylase i HHJ60_09735 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HHJ60_09740 ENOG4106BMH cytolethal distending toxin HHJ60_09745 ENOG4108TMH cytolethal distending toxin HHJ60_09755 ENOG4108VVK transcriptional Regulator, AsnC HHJ60_09780 ENOG4105C7B Threonine dehydratase HHJ60_09790 ENOG4105C01 Dihydroxy-acid dehydratase HHJ60_09795 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HHJ60_09805 ENOG4105DQF Hydrolase HHJ60_09810 ENOG4107Z6W Protein CrcB homolog HHJ60_09815 ENOG4108EUD Lysophospholipase HHJ60_09820 ENOG4105EJ2 Transcriptional regulator HHJ60_09825 ENOG4105C5Q Transcriptional regulator HHJ60_09830 ENOG4105EHV domain protein HHJ60_09840 ENOG4108V1T peptidylprolyl cis-trans isomerase HHJ60_09845 ENOG4105WWK YheO domain protein HHJ60_09850 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HHJ60_09855 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HHJ60_09870 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HHJ60_09880 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HHJ60_09885 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HHJ60_09890 ENOG4105PM1 preprotein translocase subunit SecE HHJ60_09895 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HHJ60_09915 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) HHJ60_09920 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) HHJ60_09925 ENOG4108VZM 50s ribosomal protein L10 HHJ60_09930 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) HHJ60_09935 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HHJ60_09940 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HHJ60_09945 ENOG4106HK8 GPR1 FUN34 yaaH family protein HHJ60_09950 ENOG4105E3W Two component transcriptional regulator (Winged helix family HHJ60_09955 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HHJ60_09970 ENOG4105E68 Sulfatase HHJ60_09980 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HHJ60_09985 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HHJ60_09990 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HHJ60_09995 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HHJ60_10000 ENOG4105DSJ YicC domain protein HHJ60_10005 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) HHJ60_10010 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HHJ60_10020 ENOG4108Z33 Thiol disulfide Interchange Protein HHJ60_10025 ENOG4108WFC UPF0438 protein yifE HHJ60_10030 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HHJ60_10035 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) HHJ60_10040 ENOG4108VPT UPF0234 protein HHJ60_10045 ENOG4105EAC phosphoserine phosphatase HHJ60_10050 ENOG41062Z9 Membrane HHJ60_10055 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HHJ60_10060 ENOG4105CJR Integral membrane protein (MviN HHJ60_10065 ENOG4105CFU surface antigen HHJ60_10070 ENOG4105MA0 exported protein HHJ60_10075 ENOG4105C9X ppx gppa phosphatase HHJ60_10085 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HHJ60_10100 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HHJ60_10105 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HHJ60_10110 ENOG4105C34 Pseudouridine synthase HHJ60_10115 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HHJ60_10120 ENOG4105D7A ATP-binding protein HHJ60_10125 ENOG4108MJ5 VirK protein HHJ60_10135 ENOG4105BZU Histidine kinase HHJ60_10135 ENOG4105BZU Histidine kinase HHJ60_10140 ENOG4108YZA Nitrogen regulatory protein pii HHJ60_10145 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HHJ60_10150 ENOG4105JAB phenazine biosynthesis protein, phzf family HHJ60_10155 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HHJ60_10160 ENOG410903C (LipO)protein HHJ60_10170 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HHJ60_10175 ENOG4105C1J atp-dependent rna helicase HHJ60_10180 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) HHJ60_10185 ENOG4105EZR dyp-type peroxidase family protein HHJ60_10195 ENOG4105ECY inositol monophosphatase HHJ60_10200 ENOG4105CVS RNA methyltransferase TrmH family, group 1 HHJ60_10205 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family HHJ60_10210 ENOG4105C3J Cysteine desulfurase HHJ60_10215 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HHJ60_10220 ENOG4108Z4V iron-sulfur cluster assembly HHJ60_10225 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HHJ60_10230 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) HHJ60_10235 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB HHJ60_10240 ENOG4108ZIT Ferredoxin, 2FE-2S HHJ60_10245 ENOG4105D9M gamma-glutamylcysteine synthetase HHJ60_10255 ENOG4105F3R pts system mannose fructose sorbose family iid HHJ60_10260 ENOG4105ETZ PTS System HHJ60_10265 ENOG4105DAS pts system HHJ60_10270 ENOG410667J hydrolase HHJ60_10275 ENOG4106WTF Glycosyl transferase, family 2 HHJ60_10280 ENOG4105M5K heptosyltransferase HHJ60_10285 ENOG4105K5M 30s ribosomal protein S16 HHJ60_10290 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HHJ60_10300 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HHJ60_10305 ENOG4105E0M Sulfatase HHJ60_10310 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HHJ60_10315 ENOG4105C6K Malic enzyme HHJ60_10320 ENOG4105I08 Pseudouridine synthase HHJ60_10325 ENOG4105C2C drug resistance transporter, Bcr CflA HHJ60_10330 ENOG4108Z6Z Transcriptional regulator HHJ60_10335 ENOG4105DIJ Phosphoethanolamine transferase HHJ60_10340 ENOG4105F9E Shikimate 5-dehydrogenase HHJ60_10345 ENOG4105D7W serine acetyltransferase HHJ60_10350 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HHJ60_10360 ENOG4107YZP Rhodanese domain protein HHJ60_10365 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HHJ60_10370 ENOG4108RCM Nitroreductase HHJ60_10380 ENOG4105JIM Phosphatidylserine synthase HHJ60_10385 ENOG4105EIB trna rrna methyltransferase HHJ60_10390 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HHJ60_10395 ENOG41083KI ribonuclease, T2 HHJ60_10400 ENOG4105BZA Phosphoglycerate kinase HHJ60_10405 ENOG4105D2N Aldolase HHJ60_10415 ENOG4105D7K pfkb domain protein HHJ60_10420 ENOG4105CEP NADH dehydrogenase HHJ60_10425 ENOG4107R3N Filamentation induced by cAMP protein fic HHJ60_10435 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HHJ60_10440 ENOG4105C1A potassium transporter peripheral membrane HHJ60_10445 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HHJ60_10455 ENOG4108YZY peptidylprolyl cis-trans isomerase HHJ60_10460 ENOG4105C1J atp-dependent rna helicase HHJ60_10465 ENOG4105RT1 May be involved in cell division (By similarity) HHJ60_10475 ENOG4105CUW cytochrome C-TYPE protein HHJ60_10480 ENOG4105IYZ Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HHJ60_10485 ENOG4105GXZ Ferredoxin-type protein NapH HHJ60_10490 ENOG4108BGM Quinol dehydrogenase periplasmic component HHJ60_10505 ENOG4105BZU Histidine kinase HHJ60_10510 ENOG4105D4A Cell wall formation (By similarity) HHJ60_10520 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HHJ60_10525 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) HHJ60_10530 ENOG4105MJ2 Competence protein HHJ60_10535 ENOG4105PXI polysaccharide deacetylase HHJ60_10540 ENOG41063SB peptidase HHJ60_10545 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HHJ60_10550 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) HHJ60_10555 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HHJ60_10560 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HHJ60_10565 ENOG4108RR8 protoporphyrinogen oxidase HHJ60_10595 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HHJ60_10600 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HHJ60_10610 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HHJ60_10615 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HHJ60_10620 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HHJ60_10625 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HHJ60_10640 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HHJ60_10645 ENOG41067V7 50S ribosomal protein L36 HHJ60_10650 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HHJ60_10655 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HHJ60_10660 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HHJ60_10665 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HHJ60_10670 ENOG4108ZT0 50S ribosomal protein l17 HHJ60_10680 ENOG4105W0Z cytoplasmic protein HHJ60_10685 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HHJ60_10690 ENOG4108VVQ metallophosphoesterase HHJ60_10700 ENOG4105DFP Integrase HHJ60_10780 ENOG4105DZR Type I site-specific deoxyribonuclease HHJ60_10795 ENOG4105EKX Restriction modification system DNA (Specificity HHJ60_10805 ENOG4105IEY (LipO)protein HHJ60_10810 ENOG4105M85 Bola protein HHJ60_10820 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HHJ60_10825 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HHJ60_10830 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HHJ60_10835 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) HHJ60_10840 ENOG4108EGU NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) HHJ60_10845 ENOG4105CJ2 (LipO)protein HHJ60_10855 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HHJ60_10860 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HHJ60_10870 ENOG4105D6U Sodium Glutamate Symporter HHJ60_10900 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HHJ60_10905 ENOG4105E09 nadh pyrophosphatase HHJ60_10910 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HHJ60_10915 ENOG4105R2J Conserved Protein HHJ60_10920 ENOG4105K70 DNA-binding protein HHJ60_10925 ENOG410804X Transcriptional regulator HHJ60_10930 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HHJ60_10945 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) HHJ60_10950 ENOG4105C0R drug resistance transporter emrb qaca subfamily HHJ60_10955 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HHJ60_10960 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HHJ60_10965 ENOG4105VQK sigma E regulatory protein, MucB RseB HHJ60_10970 ENOG41069PW sigma-e factor negative regulatory protein HHJ60_10975 ENOG4105EMN RNA polymerase sigma factor HHJ60_10980 ENOG4105Y75 tpr repeat protein HHJ60_10990 ENOG4105DVA methyltransferase HHJ60_11015 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) HHJ60_11020 ENOG4105KJF protein tyrosine phosphatase HHJ60_11025 ENOG4105BZ8 glutamate synthase HHJ60_11030 ENOG4105CBC glutamate synthase HHJ60_11040 ENOG4105DKP glycosyl transferase, family 9 HHJ60_11045 ENOG4105BZ1 (ABC) transporter HHJ60_11050 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HHJ60_11055 ENOG4105C5B carbamate kinase HHJ60_11065 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HHJ60_11075 ENOG4107REC cytoplasmic protein HHJ60_11080 ENOG4107R1Q Membrane protein FdrA HHJ60_11090 ENOG4108NUU Transcriptional regulator HHJ60_11100 ENOG4107REC cytoplasmic protein HHJ60_11105 ENOG4107R1Q Membrane protein FdrA HHJ60_11110 ENOG4107SNB ankyrin repeat protein YahD HHJ60_11130 ENOG4108RS6 transposase HHJ60_11135 ENOG4105D7V transposase HHJ60_11140 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HHJ60_11145 ENOG4105CDA abc transporter atp-binding protein HHJ60_11150 ENOG4105E5Q amino acid AbC transporter HHJ60_11155 ENOG4105EAB amino acid AbC transporter HHJ60_11160 ENOG4105D4P Coproporphyrinogen iii oxidase HHJ60_11165 ENOG4105XCT Protein of unknown function (DUF2489) HHJ60_11170 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HHJ60_11175 ENOG4105D3G Pseudouridine synthase HHJ60_11180 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HHJ60_11190 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HHJ60_11200 ENOG4105C26 Dehydrogenase HHJ60_11205 ENOG4105DH8 myo-inositol catabolism HHJ60_11220 ENOG4108HYK gCN5-related N-acetyltransferase HHJ60_11250 ENOG4105EDR glucose galactose transporter HHJ60_11255 ENOG4107W7X Aldolase HHJ60_11265 ENOG4105CMG Carbohydrate kinase HHJ60_11270 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HHJ60_11275 ENOG4107EDW L-fucose operon activator HHJ60_11280 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HHJ60_11285 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HHJ60_11300 ENOG4105XA0 heptosyltransferase ii HHJ60_11305 ENOG4105D16 lipopolysaccharide heptosyltransferase i HHJ60_11310 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HHJ60_11315 ENOG4107104 thymidine kinase HHJ60_11335 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HHJ60_11340 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HHJ60_11355 ENOG4105KZW UPF0381 protein HHJ60_11360 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HHJ60_11365 ENOG41060A7 DNA polymerase beta domain protein region HHJ60_11370 ENOG41062MS nucleotidyltransferase substrate binding protein HHJ60_11375 ENOG4108Q79 6-phosphogluconolactonase (EC 3.1.1.31) HHJ60_11380 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HHJ60_11385 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HHJ60_11390 ENOG4105EPD Oligopeptide transporter, Opt family HHJ60_11395 ENOG4105VEJ Heat shock protein HHJ60_11400 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HHJ60_11405 ENOG4105ETE Transcriptional regulator (LacI family HHJ60_11420 ENOG4105CMG Carbohydrate kinase HHJ60_11425 ENOG4105C2J ABC transporter HHJ60_11430 ENOG4105CNN ABC, transporter HHJ60_11435 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HHJ60_11445 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) HHJ60_11455 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HHJ60_11460 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HHJ60_11465 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HHJ60_11470 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HHJ60_11475 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) HHJ60_11485 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HHJ60_11490 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HHJ60_11495 ENOG41083MP 50s ribosomal protein l29 HHJ60_11500 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HHJ60_11510 ENOG4105DFP Integrase HHJ60_11600 ENOG41061CV Terminase small subunit HHJ60_11670 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HHJ60_11675 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HHJ60_11680 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)