locus-tag	class	description
N8E86_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N8E86_00010	COG0592	DNA-directed DNA polymerase activity
N8E86_00020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
N8E86_00025	COG1381	Involved in DNA repair and RecF pathway recombination
N8E86_00030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N8E86_00035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N8E86_00040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N8E86_00045	COG0252	asparaginase activity
N8E86_00055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
N8E86_00075	COG3133	Outer membrane lipoprotein
N8E86_00080	COG3962	Belongs to the TPP enzyme family
N8E86_00090	COG0673	inositol 2-dehydrogenase activity
N8E86_00100	COG0431	NADPH-dependent FMN reductase
N8E86_00110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
N8E86_00115	COG1216	Glycosyl transferase, family 2
N8E86_00120	COG3307	-O-antigen
N8E86_00125	COG2976	Protein conserved in bacteria
N8E86_00135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N8E86_00140	COG1426	Protein conserved in bacteria
N8E86_00145	COG0471	metal ion transport
N8E86_00145	COG0490	domain, Protein
N8E86_00150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N8E86_00160	COG4589	Belongs to the CDS family
N8E86_00165	COG0521	Mo-molybdopterin cofactor biosynthetic process
N8E86_00175	COG0628	permease
N8E86_00185	COG3063	Type IV pilus biogenesis stability protein PilW
N8E86_00190	COG0758	DNA mediated transformation
N8E86_00195	COG0742	ribosomal rna small subunit methyltransferase
N8E86_00200	COG0552	protein localization to endoplasmic reticulum
N8E86_00205	COG0584	glycerophosphoryl diester phosphodiesterase
N8E86_00210	COG2271	Major facilitator Superfamily
N8E86_00215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N8E86_00225	COG0247	lactate metabolic process
N8E86_00230	COG1349	DNA-binding transcription factor activity
N8E86_00235	COG0705	Rhomboid family
N8E86_00245	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
N8E86_00255	COG0546	phosphoglycolate phosphatase activity
N8E86_00260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N8E86_00270	COG0251	oxidation-reduction process
N8E86_00335	COG2369	cell adhesion
N8E86_00340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N8E86_00415	COG0786	glutamate:sodium symporter activity
N8E86_00430	COG0640	Transcriptional regulator
N8E86_00460	COG0551	DNA topoisomerase type I activity
N8E86_00460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N8E86_00540	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
N8E86_00545	COG1194	a g-specific adenine glycosylase
N8E86_00550	COG4213	ABC transporter substrate-binding protein
N8E86_00555	COG1129	ABC transporter
N8E86_00560	COG4214	carbohydrate transport
N8E86_00575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N8E86_00590	COG3732	PTS system glucitol sorbitol-specific
N8E86_00600	COG1028	Short-chain dehydrogenase reductase Sdr
N8E86_00605	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
N8E86_00610	COG1349	DNA-binding transcription factor activity
N8E86_00625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N8E86_00635	COG1757	Na H antiporter
N8E86_00640	COG0436	Aminotransferase
N8E86_00645	COG2115	Belongs to the xylose isomerase family
N8E86_00650	COG1070	Carbohydrate kinase
N8E86_00655	COG2207	Transcriptional regulator
N8E86_00655	COG1609	Transcriptional regulator
N8E86_00695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N8E86_00710	COG2095	MarC family integral membrane protein
N8E86_00715	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N8E86_00720	COG1114	Component of the transport system for branched-chain amino acids
N8E86_00725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
N8E86_00735	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
N8E86_00750	COG3956	TIGRFAM MazG family protein
N8E86_00760	COG0583	DNA-binding transcription factor activity
N8E86_00770	COG3119	arylsulfatase activity
N8E86_00780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N8E86_00785	COG0488	(ABC) transporter
N8E86_00815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N8E86_00835	COG0019	diaminopimelate decarboxylase activity
N8E86_00840	COG5567	small periplasmic lipoprotein
N8E86_00855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N8E86_00875	COG2195	Cleaves the N-terminal amino acid of tripeptides
N8E86_00880	COG3153	acetyltransferase
N8E86_00890	COG1230	cation diffusion facilitator family transporter
N8E86_00930	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N8E86_00955	COG2271	Major facilitator Superfamily
N8E86_00960	COG0483	inositol monophosphate 1-phosphatase activity
N8E86_00970	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N8E86_00975	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N8E86_00985	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N8E86_01010	COG0357	Ribosomal RNA small subunit methyltransferase G
N8E86_01020	COG0716	FMN binding
N8E86_01030	COG1494	fructose-1,6-bisphosphatase
N8E86_01035	COG0187	DNA topoisomerase II activity
N8E86_01045	COG4771	TonB-dependent receptor
N8E86_01045	COG1629	transport
N8E86_01050	COG4988	ABC transporter
N8E86_01055	COG1132	(ABC) transporter
N8E86_01060	COG1858	cytochrome C peroxidase
N8E86_01070	COG0733	neurotransmitter:sodium symporter activity
N8E86_01085	COG0551	DNA topoisomerase type I activity
N8E86_01105	COG3070	regulator of competence-specific genes
N8E86_01135	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N8E86_01160	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N8E86_01180	COG0201	protein transport
N8E86_01190	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N8E86_01195	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N8E86_01200	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N8E86_01205	COG0202	RNA polymerase activity
N8E86_01210	COG0203	ribosomal protein L17
N8E86_01220	COG2960	long-chain fatty acid transporting porin activity
N8E86_01225	COG3172	ATPase kinase involved in NAD metabolism
N8E86_01230	COG2129	metallophosphoesterase
N8E86_01240	COG0582	viral genome integration into host DNA
N8E86_01310	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N8E86_01320	COG0732	type I restriction modification DNA specificity domain
N8E86_01335	COG3056	Lipoprotein
N8E86_01340	COG0271	Belongs to the BolA IbaG family
N8E86_01355	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N8E86_01360	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N8E86_01365	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
N8E86_01380	COG1477	protein flavinylation
N8E86_01385	COG2991	Protein conserved in bacteria
N8E86_01395	COG1519	Transferase
N8E86_01405	COG0786	glutamate:sodium symporter activity
N8E86_01435	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N8E86_01445	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N8E86_01450	COG3068	Protein conserved in bacteria
N8E86_01460	COG1349	DNA-binding transcription factor activity
N8E86_01465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N8E86_01475	COG0259	pyridoxamine-phosphate oxidase activity
N8E86_01480	COG2814	Major facilitator Superfamily
N8E86_01485	COG1763	Mo-molybdopterin cofactor biosynthetic process
N8E86_01490	COG3086	response to oxidative stress
N8E86_01495	COG3026	antisigma factor binding
N8E86_01500	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
N8E86_01505	COG1595	DNA-templated transcription, initiation
N8E86_01520	COG2226	methyltransferase
N8E86_01545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N8E86_01550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N8E86_01555	COG0493	'glutamate synthase
N8E86_01560	COG0067	glutamate synthase
N8E86_01560	COG0070	glutamate synthase
N8E86_01560	COG0069	glutamate synthase activity
N8E86_01570	COG0859	PFAM glycosyl transferase family 9
N8E86_01575	COG1132	(ABC) transporter
N8E86_01585	COG0549	Belongs to the carbamate kinase family
N8E86_01595	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
N8E86_01605	COG1304	FMN binding
N8E86_01610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N8E86_01620	COG0583	DNA-binding transcription factor activity
N8E86_01630	COG1304	FMN binding
N8E86_01635	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N8E86_01640	COG0666	response to abiotic stimulus
N8E86_01685	COG3978	acetolactate synthase activity
N8E86_01695	COG0561	phosphatase activity
N8E86_01700	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
N8E86_01705	COG2267	carboxylic ester hydrolase activity
N8E86_01710	COG1309	transcriptional regulator
N8E86_01715	COG0583	DNA-binding transcription factor activity
N8E86_01720	COG0678	peroxiredoxin activity
N8E86_01720	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N8E86_01730	COG0545	Peptidyl-prolyl cis-trans isomerase
N8E86_01735	COG2964	Protein conserved in bacteria
N8E86_01745	COG2923	Belongs to the DsrF TusC family
N8E86_01770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N8E86_01775	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N8E86_01800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N8E86_01805	COG0081	regulation of translation
N8E86_01820	COG0085	RNA polymerase activity
N8E86_01825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N8E86_01830	COG1584	GPR1 FUN34 yaaH family protein
N8E86_01835	COG0745	RESPONSE REGULATOR receiver
N8E86_01840	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N8E86_01855	COG3083	sulfuric ester hydrolase activity
N8E86_01860	COG0402	S-adenosylhomocysteine deaminase activity
N8E86_01870	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N8E86_01875	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N8E86_01880	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N8E86_01885	COG1561	YicC-like family, N-terminal region
N8E86_01890	COG0354	folic acid binding
N8E86_01900	COG3084	Protein conserved in bacteria
N8E86_01905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N8E86_01910	COG3085	chromosome segregation
N8E86_01915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N8E86_01930	COG0560	Phosphoserine phosphatase
N8E86_01940	COG0268	Binds directly to 16S ribosomal RNA
N8E86_01945	COG0728	peptidoglycan biosynthetic process
N8E86_01950	COG0729	surface antigen
N8E86_01955	COG2911	Protein conserved in bacteria
N8E86_01960	COG0248	Ppx GppA phosphatase
N8E86_01965	COG0668	transmembrane transport
N8E86_01970	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N8E86_01975	COG2175	clavaminate synthase activity
N8E86_01990	COG1496	oxidoreductase activity
N8E86_02005	COG0433	COG0433 Predicted ATPase
N8E86_02010	COG2990	Protein conserved in bacteria
N8E86_02015	COG0004	ammonium transporteR
N8E86_02020	COG0004	ammonium transporteR
N8E86_02025	COG0004	ammonium transporteR
N8E86_02045	COG2853	Lipoprotein
N8E86_02055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N8E86_02060	COG0513	Belongs to the DEAD box helicase family
N8E86_02070	COG2837	iron assimilation
N8E86_02085	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
N8E86_02090	COG1959	2 iron, 2 sulfur cluster binding
N8E86_02100	COG0822	iron-sulfur transferase activity
N8E86_02110	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N8E86_02115	COG0443	Heat shock 70 kDa protein
N8E86_02120	COG0633	Ferredoxin
N8E86_02135	COG3716	PTS system mannose fructose sorbose family IID component
N8E86_02140	COG3715	PTS system
N8E86_02145	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N8E86_02145	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
N8E86_02150	COG0561	phosphatase activity
N8E86_02155	COG0463	Glycosyl transferase, family 2
N8E86_02160	COG0859	PFAM glycosyl transferase family 9
N8E86_02165	COG0228	four-way junction DNA binding
N8E86_02170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N8E86_02180	COG0335	large ribosomal subunit rRNA binding
N8E86_02185	COG1368	sulfuric ester hydrolase activity
N8E86_02195	COG0281	malic enzyme
N8E86_02195	COG0280	phosphate acetyltransferase
N8E86_02205	COG2814	Major facilitator Superfamily
N8E86_02210	COG0789	Transcriptional regulator
N8E86_02215	COG2194	sulfuric ester hydrolase activity
N8E86_02225	COG1045	serine acetyltransferase
N8E86_02240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N8E86_02245	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N8E86_02250	COG0778	Nitroreductase
N8E86_02260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N8E86_02265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N8E86_02270	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N8E86_02275	COG3719	Belongs to the RNase T2 family
N8E86_02280	COG0126	phosphoglycerate kinase activity
N8E86_02285	COG0191	fructose-bisphosphate aldolase activity
N8E86_02295	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N8E86_02300	COG1252	NADH dehydrogenase
N8E86_02315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N8E86_02315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N8E86_02320	COG0569	domain protein
N8E86_02325	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
N8E86_02360	COG0513	Belongs to the DEAD box helicase family
N8E86_02365	COG4785	May be involved in cell division
N8E86_02375	COG3005	denitrification pathway
N8E86_02380	COG3043	anaerobic respiration
N8E86_02385	COG0348	domain, Protein
N8E86_02395	COG0243	molybdopterin cofactor binding
N8E86_02400	COG3062	negative regulation of establishment of protein localization
N8E86_02405	COG3850	Histidine kinase
N8E86_02420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N8E86_02430	COG1040	competence protein
N8E86_02435	COG2861	carbohydrate metabolic process
N8E86_02440	COG4942	peptidase
N8E86_02450	COG0425	Belongs to the sulfur carrier protein TusA family
N8E86_02455	COG1739	Uncharacterized protein family UPF0029
N8E86_02460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N8E86_02465	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
N8E86_02515	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
N8E86_02525	COG2301	Belongs to the HpcH HpaI aldolase family
N8E86_02530	COG3051	citrate lyase alpha subunit
N8E86_02535	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
N8E86_02535	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
N8E86_02540	COG0471	metal ion transport
N8E86_02550	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
N8E86_02565	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
N8E86_02590	COG3623	hexulose-6-phosphate isomerase
N8E86_02595	COG0235	Class ii aldolase
N8E86_02600	COG0561	phosphatase activity
N8E86_02605	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
N8E86_02620	COG4795	General secretion pathway protein
N8E86_02625	COG2165	general secretion pathway protein
N8E86_02655	COG3064	Membrane
N8E86_02660	COG0848	biopolymer transport protein
N8E86_02665	COG0811	peptide transport
N8E86_02670	COG0824	Thioesterase
N8E86_02675	COG3790	cyd operon protein YbgE
N8E86_02685	COG1294	oxidase, subunit
N8E86_02690	COG1271	oxidase subunit
N8E86_02700	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
N8E86_02705	COG0312	modulator of DNA gyrase
N8E86_02725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N8E86_02735	COG1216	Glycosyl transferase, family 2
N8E86_02740	COG3306	glycosyltransferase involved in LPS biosynthesis
N8E86_02755	COG1217	gtp-binding protein TYPA
N8E86_02760	COG0174	glutamine synthetase
N8E86_02785	COG4160	amino acid transport
N8E86_02790	COG4215	(ABC) transporter
N8E86_02795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8E86_02800	COG1126	abc transporter atp-binding protein
N8E86_02810	COG1393	Belongs to the ArsC family
N8E86_02815	COG3036	rescue of stalled ribosome
N8E86_02825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N8E86_02830	COG4137	Cytochrome C assembly protein
N8E86_02835	COG4536	flavin adenine dinucleotide binding
N8E86_02840	COG0811	peptide transport
N8E86_02845	COG0848	biopolymer transport protein
N8E86_02860	COG0246	Mannitol dehydrogenase
N8E86_02865	COG3722	fumarate hydratase activity
N8E86_02875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N8E86_02875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N8E86_02885	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
N8E86_02920	COG1027	Aspartate ammonia-lyase
N8E86_02925	COG1022	Amp-dependent synthetase and ligase
N8E86_02930	COG0456	acetyltransferase
N8E86_02935	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
N8E86_02955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N8E86_02960	COG1114	Component of the transport system for branched-chain amino acids
N8E86_02965	COG2183	response to ionizing radiation
N8E86_02985	COG1309	transcriptional regulator
N8E86_02990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N8E86_02995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
N8E86_03005	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N8E86_03010	COG1446	asparaginase
N8E86_03015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N8E86_03020	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
N8E86_03025	COG1447	Phosphotransferase system cellobiose-specific component IIA
N8E86_03040	COG5645	(Lipo)protein
N8E86_03045	COG0210	DNA helicase
N8E86_03065	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
N8E86_03090	COG0038	chloride channel
N8E86_03100	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
N8E86_03105	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N8E86_03110	COG3091	SprT-like family
N8E86_03120	COG0326	Molecular chaperone. Has ATPase activity
N8E86_03140	COG0330	HflC and HflK could
N8E86_03155	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N8E86_03170	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
N8E86_03175	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N8E86_03180	COG0470	DNA polymerase III
N8E86_03185	COG0084	hydrolase, TatD family'
N8E86_03195	COG1253	flavin adenine dinucleotide binding
N8E86_03200	COG0254	rRNA binding
N8E86_03205	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N8E86_03210	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N8E86_03225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N8E86_03230	COG1472	Belongs to the glycosyl hydrolase 3 family
N8E86_03240	COG0537	adenosine 5'-monophosphoramidase activity
N8E86_03245	COG2116	formate transmembrane transporter activity
N8E86_03250	COG1882	Formate acetyltransferase
N8E86_03255	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N8E86_03260	COG2017	converts alpha-aldose to the beta-anomer
N8E86_03270	COG1085	galactose-1-phosphate uridylyltransferase
N8E86_03275	COG1879	ABC-type sugar transport system periplasmic component
N8E86_03280	COG1129	ABC transporter
N8E86_03285	COG4211	Belongs to the binding-protein-dependent transport system permease family
N8E86_03300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N8E86_03305	COG1138	Cytochrome C-type biogenesis protein
N8E86_03315	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N8E86_03320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N8E86_03325	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N8E86_03330	COG4133	protoheme IX ABC transporter activity
N8E86_03345	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N8E86_03350	COG0066	3-isopropylmalate dehydratase activity
N8E86_03355	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N8E86_03360	COG2233	PERMEase
N8E86_03365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N8E86_03370	COG3161	chorismate lyase activity
N8E86_03385	COG0107	imidazoleglycerol-phosphate synthase activity
N8E86_03395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
N8E86_03405	COG4804	nuclease activity
N8E86_03410	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N8E86_03410	COG0131	Imidazoleglycerol-phosphate dehydratase
N8E86_03430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N8E86_03435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
N8E86_03440	COG2226	methyltransferase
N8E86_03445	COG0814	amino acid
N8E86_03455	COG4783	chaperone-mediated protein folding
N8E86_03475	COG1238	metal cluster binding
N8E86_03500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N8E86_03505	COG0110	maltose O-acetyltransferase activity
N8E86_03510	COG1238	metal cluster binding
N8E86_03520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N8E86_03525	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N8E86_03530	COG1555	photosystem II stabilization
N8E86_03535	COG2252	PERMEase
N8E86_03540	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N8E86_03545	COG2814	Major facilitator Superfamily
N8E86_03550	COG0385	Bile acid
N8E86_03555	COG0784	Response regulator, receiver
N8E86_03555	COG2198	Histidine kinase
N8E86_03555	COG5002	protein histidine kinase activity
N8E86_03575	COG0105	UTP biosynthetic process
N8E86_03615	COG0681	Belongs to the peptidase S26 family
N8E86_03640	COG0557	exoribonuclease II activity
N8E86_03650	COG2814	Major facilitator Superfamily
N8E86_03655	COG1566	PFAM secretion protein HlyD family protein
N8E86_03660	COG1846	Transcriptional regulator
N8E86_03670	COG2831	hemolysin activation secretion protein
N8E86_03690	COG3210	domain, Protein
N8E86_03735	COG3209	COG3209 Rhs family protein
N8E86_03750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N8E86_03755	COG0697	spore germination
N8E86_03770	COG0142	geranyltranstransferase activity
N8E86_03775	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N8E86_03785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N8E86_03790	COG0626	cystathionine gamma-synthase activity
N8E86_03810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
N8E86_03815	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N8E86_03820	COG0720	synthase
N8E86_03825	COG0602	queuosine metabolic process
N8E86_03830	COG1793	dna ligase
N8E86_03835	COG0363	glucosamine-6-phosphate deaminase activity
N8E86_03840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N8E86_03845	COG0590	tRNA wobble adenosine to inosine editing
N8E86_03860	COG0730	response to heat
N8E86_03865	COG0494	nUDIX hydrolase
N8E86_03875	COG3023	N-Acetylmuramoyl-L-alanine amidase
N8E86_03880	COG4969	Belongs to the N-Me-Phe pilin family
N8E86_03885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N8E86_03890	COG0528	UMP kinase activity
N8E86_03900	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N8E86_03910	COG0575	Belongs to the CDS family
N8E86_03915	COG0750	zinc metalloprotease
N8E86_03925	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
N8E86_03930	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N8E86_03935	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N8E86_03950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N8E86_03960	COG1466	dna polymerase III delta subunit
N8E86_03965	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
N8E86_03990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N8E86_03995	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
N8E86_04000	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N8E86_04030	COG0328	RNA-DNA hybrid ribonuclease activity
N8E86_04045	COG3716	PTS system mannose fructose sorbose family IID component
N8E86_04050	COG3715	PTS system
N8E86_04055	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
N8E86_04055	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N8E86_04060	COG1459	type II secretion system
N8E86_04070	COG0237	dephospho-CoA kinase activity
N8E86_04070	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
N8E86_04085	COG1115	amino acid carrier protein
N8E86_04090	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
N8E86_04095	COG1917	Cupin 2, conserved barrel domain protein
N8E86_04095	COG4977	sequence-specific DNA binding
N8E86_04100	COG5413	integral membrane protein
N8E86_04110	COG4178	(ABC) transporter
N8E86_04120	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
N8E86_04135	COG1012	belongs to the aldehyde dehydrogenase family
N8E86_04135	COG1454	alcohol dehydrogenase
N8E86_04140	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N8E86_04145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N8E86_04155	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
N8E86_04160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N8E86_04165	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N8E86_04170	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N8E86_04175	COG0052	Belongs to the universal ribosomal protein uS2 family
N8E86_04205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N8E86_04215	COG2990	Protein conserved in bacteria
N8E86_04220	COG0612	Peptidase, M16
N8E86_04225	COG4771	TonB-dependent receptor
N8E86_04230	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
N8E86_04235	COG0539	negative regulation of cytoplasmic translation
N8E86_04240	COG0776	regulation of translation
N8E86_04245	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
N8E86_04250	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
N8E86_04260	COG0023	Translation Initiation Factor
N8E86_04280	COG0745	RESPONSE REGULATOR receiver
N8E86_04285	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N8E86_04290	COG0151	Belongs to the GarS family
N8E86_04305	COG2259	Doxx family
N8E86_04325	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N8E86_04330	COG4172	Belongs to the ABC transporter superfamily
N8E86_04335	COG4172	Belongs to the ABC transporter superfamily
N8E86_04340	COG4171	peptide transport system, permease
N8E86_04345	COG4168	peptide transport system, permease
N8E86_04350	COG4166	transmembrane transport
N8E86_04355	COG3106	COG3106 Predicted ATPase
N8E86_04365	COG3283	Transcriptional regulator of aromatic amino acids metabolism
N8E86_04370	COG0531	amino acid
N8E86_04380	COG0012	GTP binding
N8E86_04390	COG2867	negative regulation of translational initiation
N8E86_04400	COG2850	peptidyl-arginine hydroxylation
N8E86_04415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N8E86_04420	COG0739	heme binding
N8E86_04430	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N8E86_04455	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N8E86_04465	COG0732	type I restriction modification DNA specificity domain
N8E86_04480	COG0443	Heat shock 70 kDa protein
N8E86_04485	COG0484	heat shock protein binding
N8E86_04490	COG3366	ferrous iron transmembrane transporter activity
N8E86_04510	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N8E86_04515	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N8E86_04525	COG1643	Atp-dependent helicase
N8E86_04540	COG3423	Transcriptional regulator
N8E86_04545	COG2801	Transposase and inactivated derivatives
N8E86_04550	COG2842	Transposition protein
N8E86_04570	COG4396	Host-nuclease inhibitor protein Gam
N8E86_04600	COG4382	Mu-like prophage protein Gp16
N8E86_04605	COG5566	PFAM Mor transcription activator
N8E86_04615	COG3023	N-Acetylmuramoyl-L-alanine amidase
N8E86_04635	COG0640	Transcriptional regulator
N8E86_04645	COG4373	Mu-like prophage FluMu protein gp28
N8E86_04650	COG4383	Mu-like prophage protein gp29
N8E86_04655	COG2369	cell adhesion
N8E86_04670	COG4388	Caudovirus prohead serine protease
N8E86_04675	COG4397	Mu-like prophage major head subunit gpT
N8E86_04685	COG4387	Mu-like prophage protein GP36
N8E86_04690	COG5003	unkown
N8E86_04700	COG4386	tail sheath protein
N8E86_04710	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
N8E86_04715	COG3941	tape measure
N8E86_04720	COG4228	DNA circulation
N8E86_04735	COG4384	Bacteriophage Mu Gp45 protein
N8E86_04740	COG4381	Mu-like prophage protein gp46
N8E86_04745	COG3299	homolog of phage Mu protein gp47
N8E86_04750	COG3778	Protein conserved in bacteria
N8E86_04755	COG5301	cellulose 1,4-beta-cellobiosidase activity
N8E86_04790	COG3392	D12 class N6 adenine-specific DNA methyltransferase
N8E86_04815	COG0471	metal ion transport
N8E86_04825	COG0583	DNA-binding transcription factor activity
N8E86_04830	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
N8E86_04835	COG1687	branched-chain amino acid
N8E86_04855	COG2864	formate dehydrogenase
N8E86_04860	COG0437	4 iron, 4 sulfur cluster binding
N8E86_04880	COG2217	Heavy metal translocating P-type atpase
N8E86_04890	COG0531	amino acid
N8E86_04895	COG1982	Orn Lys Arg decarboxylase major
N8E86_04935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N8E86_04945	COG3021	interspecies interaction between organisms
N8E86_04950	COG0251	oxidation-reduction process
N8E86_04960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N8E86_04960	COG0519	Catalyzes the synthesis of GMP from XMP
N8E86_04975	COG0517	IMP dehydrogenase activity
N8E86_04975	COG0516	GMP reductase activity
N8E86_04980	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
N8E86_04980	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
N8E86_05030	COG0159	tryptophan synthase activity
N8E86_05040	COG0135	phosphoribosylanthranilate isomerase activity
N8E86_05040	COG0134	indole-3-glycerol-phosphate synthase activity
N8E86_05050	COG1942	4-Oxalocrotonate Tautomerase
N8E86_05055	COG0512	Glutamine amidotransferase of anthranilate synthase
N8E86_05060	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N8E86_05070	COG2927	DNA polymerase III (CHI subunit)
N8E86_05075	COG2153	protein acetylation
N8E86_05100	COG0525	valine-tRNA ligase activity
N8E86_05105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N8E86_05125	COG2814	Major facilitator Superfamily
N8E86_05145	COG4221	oxidoreductase activity
N8E86_05160	COG3094	Invasion gene expression up-regulator, SirB
N8E86_05165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N8E86_05175	COG0735	belongs to the Fur family
N8E86_05180	COG0716	FMN binding
N8E86_05190	COG0596	Alpha beta hydrolase
N8E86_05195	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
N8E86_05200	COG0318	PFAM AMP-dependent synthetase and ligase
N8E86_05205	COG3264	Mechanosensitive ion channel
N8E86_05205	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
N8E86_05215	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
N8E86_05220	COG0730	response to heat
N8E86_05225	COG1560	Kdo2-lipid A biosynthetic process
N8E86_05230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N8E86_05235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N8E86_05240	COG1966	Carbon starvation protein
N8E86_05245	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N8E86_05250	COG1177	transmembrane transport
N8E86_05255	COG1176	ABC-type spermidine putrescine transport system, permease component I
N8E86_05260	COG3842	ATPase activity
N8E86_05270	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
N8E86_05275	COG4143	(ABC) transporter
N8E86_05280	COG1178	ABC-type Fe3 transport system permease component
N8E86_05285	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
N8E86_05295	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N8E86_05300	COG0730	response to heat
N8E86_05315	COG0786	glutamate:sodium symporter activity
N8E86_05320	COG2005	Transcriptional regulator
N8E86_05325	COG0725	ABC transporter, periplasmic molybdate-binding protein
N8E86_05330	COG4149	molybdate abc transporter
N8E86_05345	COG3102	Protein conserved in bacteria
N8E86_05370	COG0305	Participates in initiation and elongation during chromosome replication
N8E86_05390	COG2932	Transcriptional regulator
N8E86_05425	COG0494	nUDIX hydrolase
N8E86_05450	COG1929	Belongs to the glycerate kinase type-1 family
N8E86_05455	COG2610	gluconate transmembrane transporter activity
N8E86_05460	COG3835	regulator
N8E86_05465	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N8E86_05470	COG1448	Aminotransferase
N8E86_05475	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
N8E86_05480	COG0288	reversible hydration of carbon dioxide
N8E86_05485	COG0306	phosphate transporter
N8E86_05490	COG1392	Phosphate transport regulator
N8E86_05495	COG3025	triphosphatase activity
N8E86_05500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N8E86_05505	COG3468	outer membrane autotransporter barrel domain protein
N8E86_05505	COG3266	domain, Protein
N8E86_05515	COG0352	thiamine-phosphate diphosphorylase activity
N8E86_05520	COG0351	phosphomethylpyrimidine kinase
N8E86_05530	COG2333	competence protein COMEC
N8E86_05530	COG0658	competence protein
N8E86_05535	COG1132	(ABC) transporter
N8E86_05540	COG1663	tetraacyldisaccharide 4'-kinase activity
N8E86_05545	COG2835	tetraacyldisaccharide 4'-kinase activity
N8E86_05550	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
N8E86_05555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
N8E86_05560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
N8E86_05565	COG1116	anion transmembrane transporter activity
N8E86_05570	COG0322	excinuclease ABC activity
N8E86_05575	COG0586	Pfam SNARE associated Golgi protein
N8E86_05580	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
N8E86_05610	COG0673	inositol 2-dehydrogenase activity
N8E86_05620	COG0307	riboflavin synthase, alpha
N8E86_05645	COG0671	phosphoesterase, PA-phosphatase related
N8E86_05650	COG1940	carbohydrate kinase activity
N8E86_05690	COG1028	Short-chain dehydrogenase reductase Sdr
N8E86_05695	COG1115	amino acid carrier protein
N8E86_05700	COG0515	serine threonine protein kinase
N8E86_05715	COG0195	Participates in both transcription termination and antitermination
N8E86_05740	COG2350	Protein conserved in bacteria
N8E86_05745	COG1607	acyl-coa hydrolase
N8E86_05760	COG3047	cAMP biosynthetic process
N8E86_05775	COG0247	lactate metabolic process
N8E86_05775	COG0277	FAD linked oxidase domain protein
N8E86_05785	COG1704	LemA family
N8E86_05830	COG4991	sh3 domain protein
N8E86_05835	COG0617	tRNA 3'-terminal CCA addition
N8E86_05840	COG3955	Domain of unknown function (DUF1919)
N8E86_05845	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
N8E86_05850	COG1984	allophanate hydrolase subunit 2
N8E86_05855	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N8E86_05860	COG1914	H( )-stimulated, divalent metal cation uptake system
N8E86_05865	COG0826	peptidase U32
N8E86_05875	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N8E86_05885	COG0708	Exodeoxyribonuclease III
N8E86_05895	COG0616	signal peptide processing
N8E86_05900	COG1840	ABC-type Fe3 transport system, periplasmic component
N8E86_05905	COG1408	metallophosphoesterase
N8E86_05910	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N8E86_05915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N8E86_05920	COG2863	cytochrome
N8E86_05930	COG1199	ATP-dependent helicase activity
N8E86_05935	COG1214	PFAM Peptidase M22, glycoprotease
N8E86_05940	COG0318	PFAM AMP-dependent synthetase and ligase
N8E86_05945	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
N8E86_05960	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
N8E86_05965	COG4988	ABC transporter
N8E86_05970	COG0492	ferredoxin-NADP+ reductase activity
N8E86_05975	COG3118	belongs to the thioredoxin family
N8E86_05980	COG2610	gluconate transmembrane transporter activity
N8E86_05985	COG3265	gluconokinase activity
N8E86_05990	COG0488	(ABC) transporter
N8E86_05995	COG0733	neurotransmitter:sodium symporter activity
N8E86_06000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N8E86_06015	COG4658	electron transport chain
N8E86_06020	COG4656	Part of a membrane complex involved in electron transport
N8E86_06030	COG4657	Part of a membrane complex involved in electron transport
N8E86_06035	COG1090	epimerase
N8E86_06040	COG1438	arginine binding
N8E86_06045	COG0039	L-malate dehydrogenase activity
N8E86_06055	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
N8E86_06060	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N8E86_06060	COG0517	IMP dehydrogenase activity
N8E86_06090	COG0285	dihydrofolate synthase activity
N8E86_06095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N8E86_06100	COG3140	Belongs to the UPF0181 family
N8E86_06105	COG1278	Cold shock
N8E86_06120	COG1609	Transcriptional regulator
N8E86_06135	COG1067	ATP-dependent peptidase activity
N8E86_06145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N8E86_06150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N8E86_06155	COG2252	PERMEase
N8E86_06160	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
N8E86_06165	COG1074	ATP-dependent DNA helicase activity
N8E86_06170	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N8E86_06185	COG1940	carbohydrate kinase activity
N8E86_06185	COG1846	Transcriptional regulator
N8E86_06190	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N8E86_06195	COG0788	formyltetrahydrofolate deformylase activity
N8E86_06200	COG0588	phosphoglycerate mutase activity
N8E86_06210	COG0564	pseudouridine synthase activity
N8E86_06225	COG0776	regulation of translation
N8E86_06230	COG0791	NLP P60 protein
N8E86_06255	COG0697	spore germination
N8E86_06260	COG2925	Exonuclease
N8E86_06275	COG2969	positive regulation of protein catabolic process
N8E86_06300	COG3098	single-species biofilm formation
N8E86_06305	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
N8E86_06310	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N8E86_06310	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N8E86_06315	COG1611	Belongs to the LOG family
N8E86_06320	COG1215	transferase activity, transferring glycosyl groups
N8E86_06325	COG0842	Transport permease protein
N8E86_06330	COG1131	(ABC) transporter
N8E86_06335	COG3101	peptidyl-lysine hydroxylation
N8E86_06345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
N8E86_06365	COG1523	belongs to the glycosyl hydrolase 13 family
N8E86_06370	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
N8E86_06375	COG1640	4-alpha-glucanotransferase
N8E86_06380	COG3152	Membrane
N8E86_06395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N8E86_06400	COG1136	(ABC) transporter
N8E86_06400	COG0577	efflux transmembrane transporter activity
N8E86_06405	COG1538	Outer membrane efflux protein
N8E86_06415	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N8E86_06420	COG0508	dehydrogenase complex catalyzes the overall conversion of
N8E86_06425	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
N8E86_06430	COG2190	(PTS) system
N8E86_06435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N8E86_06440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N8E86_06445	COG1162	GTPase activity
N8E86_06450	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
N8E86_06470	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N8E86_06475	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N8E86_06480	COG3549	Plasmid maintenance system killer
N8E86_06500	COG1522	sequence-specific DNA binding
N8E86_06510	COG1346	cytolysis
N8E86_06515	COG1380	Effector of murein hydrolase LrgA
N8E86_06520	COG1525	nuclease
N8E86_06530	COG2166	iron-sulfur cluster assembly
N8E86_06535	COG2268	Band 7 protein
N8E86_06550	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
N8E86_06555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N8E86_06555	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N8E86_06565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N8E86_06570	COG0617	tRNA 3'-terminal CCA addition
N8E86_06575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N8E86_06580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N8E86_06580	COG0301	tRNA thio-modification
N8E86_06590	COG0142	geranyltranstransferase activity
N8E86_06600	COG1534	Rna-binding protein
N8E86_06610	COG3217	Mosc domain protein beta barrel domain protein
N8E86_06610	COG0633	Ferredoxin
N8E86_06615	COG2808	Putative FMN-binding domain
N8E86_06625	COG1605	Chorismate mutase
N8E86_06625	COG0287	Prephenate dehydrogenase
N8E86_06630	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N8E86_06635	COG0613	PHP domain protein
N8E86_06640	COG0167	dihydroorotate dehydrogenase activity
N8E86_06645	COG0308	aminopeptidase N
N8E86_06650	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N8E86_06700	COG1286	toxin biosynthetic process
N8E86_06715	COG0280	phosphate acetyltransferase
N8E86_06715	COG0857	belongs to the CobB CobQ family
N8E86_06720	COG0668	transmembrane transport
N8E86_06725	COG0795	lipopolysaccharide-transporting ATPase activity
N8E86_06730	COG0795	lipopolysaccharide-transporting ATPase activity
N8E86_06740	COG0675	Transposase, IS605 OrfB family
N8E86_06765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N8E86_06770	COG2226	methyltransferase
N8E86_06775	COG1944	ATP diphosphatase activity
N8E86_06780	COG3105	Protein conserved in bacteria
N8E86_06785	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N8E86_06800	COG0633	Ferredoxin
N8E86_06810	COG1280	lysine exporter protein (LysE YggA)
N8E86_06815	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N8E86_06820	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N8E86_06825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N8E86_06835	COG0814	amino acid
N8E86_06845	COG2062	phosphohistidine phosphatase, SixA
N8E86_06855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N8E86_06865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N8E86_06870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N8E86_06870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N8E86_06875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N8E86_06915	COG2999	glutathione oxidoreductase activity
N8E86_06930	COG3306	glycosyltransferase involved in LPS biosynthesis
N8E86_06950	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
N8E86_06955	COG3683	transport system, periplasmic component
N8E86_06960	COG0488	(ABC) transporter
N8E86_06980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N8E86_06985	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
N8E86_06990	COG1957	nucleoside hydrolase
N8E86_06995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N8E86_07000	COG0670	Belongs to the BI1 family
N8E86_07005	COG2920	part of a sulfur-relay system
N8E86_07015	COG1121	(ABC) transporter
N8E86_07020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N8E86_07025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N8E86_07030	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
N8E86_07035	COG2949	membrane
N8E86_07045	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
N8E86_07050	COG4591	ABC-type transport system involved in lipoprotein release permease component
N8E86_07055	COG1136	(ABC) transporter
N8E86_07060	COG4591	ABC-type transport system involved in lipoprotein release permease component
N8E86_07065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N8E86_07085	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N8E86_07095	COG1289	transmembrane transporter activity
N8E86_07110	COG0314	molybdopterin synthase activity
N8E86_07115	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
N8E86_07120	COG0315	cyclic pyranopterin monophosphate synthase activity
N8E86_07165	COG1696	Membrane protein involved in D-alanine export
N8E86_07175	COG0303	'Molybdopterin
N8E86_07180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N8E86_07185	COG2431	L-lysine efflux transmembrane transporter activity
N8E86_07190	COG1528	Iron-storage protein
N8E86_07195	COG1528	Iron-storage protein
N8E86_07205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
N8E86_07210	COG0589	response to stress
N8E86_07215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
N8E86_07215	COG2885	chlorophyll binding
N8E86_07220	COG2171	N-acyltransferase activity
N8E86_07225	COG0583	DNA-binding transcription factor activity
N8E86_07235	COG0009	L-threonylcarbamoyladenylate synthase
N8E86_07250	COG0792	nuclease activity
N8E86_07255	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N8E86_07260	COG2823	Periplasmic or secreted lipoprotein
N8E86_07265	COG0210	DNA helicase
N8E86_07285	COG0583	DNA-binding transcription factor activity
N8E86_07290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N8E86_07305	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N8E86_07310	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N8E86_07325	COG0626	cystathionine gamma-synthase activity
N8E86_07330	COG0450	alkyl hydroperoxide reductase
N8E86_07335	COG3100	YcgL domain-containing protein
N8E86_07340	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N8E86_07340	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N8E86_07345	COG1560	Kdo2-lipid A biosynthetic process
N8E86_07350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N8E86_07355	COG3108	Peptidase M15
N8E86_07360	COG2989	Protein conserved in bacteria
N8E86_07365	COG0793	Belongs to the peptidase S41A family
N8E86_07370	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
N8E86_07375	COG2995	paraquat-inducible protein a
N8E86_07380	COG3008	intermembrane lipid transfer
N8E86_07385	COG0187	DNA topoisomerase II activity
N8E86_07395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N8E86_07400	COG1328	CTP reductase activity
N8E86_07405	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
N8E86_07430	COG0583	DNA-binding transcription factor activity
N8E86_07435	COG0616	signal peptide processing
N8E86_07440	COG0778	Nitroreductase
N8E86_07450	COG4224	UPF0291 protein
N8E86_07460	COG0039	L-malate dehydrogenase activity
N8E86_07465	COG0440	acetolactate synthase activity
N8E86_07470	COG0028	Belongs to the TPP enzyme family
N8E86_07475	COG1757	Na H antiporter
N8E86_07490	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N8E86_07515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N8E86_07520	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
N8E86_07525	COG0494	nUDIX hydrolase
N8E86_07535	COG1876	peptidase activity
N8E86_07540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N8E86_07545	COG1393	Belongs to the ArsC family
N8E86_07565	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N8E86_07570	COG0083	homoserine kinase activity
N8E86_07575	COG0460	homoserine dehydrogenase
N8E86_07575	COG0527	aspartate kinase activity
N8E86_07585	COG0346	lactoylglutathione lyase activity
N8E86_07590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
N8E86_07595	COG2056	Na+-H+ antiporter family
N8E86_07600	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N8E86_07600	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
N8E86_07600	COG0506	proline dehydrogenase activity
N8E86_07605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N8E86_07620	COG3945	hemerythrin HHE cation binding domain
N8E86_07625	COG1862	Preprotein translocase
N8E86_07630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N8E86_07635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N8E86_07640	COG0741	lytic transglycosylase activity
N8E86_07655	COG4221	oxidoreductase activity
N8E86_07660	COG2814	Major facilitator Superfamily
N8E86_07695	COG3210	domain, Protein
N8E86_07725	COG0583	DNA-binding transcription factor activity
N8E86_07730	COG0642	Histidine kinase
N8E86_07735	COG0745	RESPONSE REGULATOR receiver
N8E86_07740	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N8E86_07750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
N8E86_07770	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
N8E86_07775	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
N8E86_07805	COG3119	arylsulfatase activity
N8E86_07815	COG2089	acid synthase
N8E86_07830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N8E86_07840	COG1621	beta-fructofuranosidase activity
N8E86_07855	COG0802	atpase or kinase
N8E86_07860	COG1388	LysM domain
N8E86_07860	COG0860	N-Acetylmuramoyl-L-alanine amidase
N8E86_07865	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
N8E86_07875	COG1923	regulation of RNA biosynthetic process
N8E86_07880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N8E86_07890	COG3099	Belongs to the UPF0263 family
N8E86_07900	COG3596	GTP binding
N8E86_07935	COG2378	regulation of single-species biofilm formation
N8E86_07950	COG1741	Belongs to the pirin family
N8E86_07955	COG2951	lytic endotransglycosylase activity
N8E86_07960	COG1216	Glycosyl transferase, family 2
N8E86_07965	COG1216	Glycosyl transferase, family 2
N8E86_07975	COG3306	glycosyltransferase involved in LPS biosynthesis
N8E86_07985	COG5039	Polysaccharide pyruvyl transferase
N8E86_07990	COG1434	Gram-negative-bacterium-type cell wall biogenesis
N8E86_07995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N8E86_08000	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N8E86_08000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N8E86_08005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N8E86_08005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N8E86_08015	COG0489	protein tyrosine kinase activity
N8E86_08020	COG0672	)-iron permease
N8E86_08035	COG1136	(ABC) transporter
N8E86_08035	COG0577	efflux transmembrane transporter activity
N8E86_08045	COG1136	(ABC) transporter
N8E86_08050	COG0676	glucose-6-phosphate 1-epimerase activity
N8E86_08070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
N8E86_08075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
N8E86_08080	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N8E86_08085	COG2885	chlorophyll binding
N8E86_08085	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
N8E86_08095	COG2824	Alkylphosphonate utilization operon protein PhnA
N8E86_08100	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
N8E86_08105	COG1120	ATPase activity
N8E86_08120	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
N8E86_08125	COG4774	siderophore transport
N8E86_08130	COG4774	siderophore transport
N8E86_08140	COG0814	amino acid
N8E86_08145	COG2964	Protein conserved in bacteria
N8E86_08155	COG0469	pyruvate kinase activity
N8E86_08160	COG0778	Nitroreductase
N8E86_08175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N8E86_08185	COG0508	dehydrogenase complex catalyzes the overall conversion of
N8E86_08190	COG0567	Dehydrogenase, E1 component
N8E86_08195	COG0372	Belongs to the citrate synthase family
N8E86_08200	COG3381	protein complex oligomerization
N8E86_08205	COG2249	NAD(P)H dehydrogenase (quinone) activity
N8E86_08215	COG0330	HflC and HflK could
N8E86_08245	COG1846	Transcriptional regulator
N8E86_08245	COG1940	carbohydrate kinase activity
N8E86_08260	COG0497	DNA recombination
N8E86_08265	COG0360	Binds together with S18 to 16S ribosomal RNA
N8E86_08270	COG2965	DNA replication, synthesis of RNA primer
N8E86_08285	COG3676	manually curated
N8E86_08300	COG1530	ribonuclease E activity
N8E86_08360	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
N8E86_08370	COG0024	Methionine aminopeptidase
N8E86_08375	COG0316	Belongs to the HesB IscA family
N8E86_08380	COG3112	Uncharacterised protein family (UPF0231)
N8E86_08385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
N8E86_08395	COG4166	transmembrane transport
N8E86_08400	COG2832	Protein of unknown function (DUF454)
N8E86_08405	COG0339	signal peptide processing
N8E86_08410	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
N8E86_08415	COG1053	succinate dehydrogenase
N8E86_08420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N8E86_08430	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
N8E86_08455	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
N8E86_08460	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
N8E86_08465	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
N8E86_08475	COG1278	Cold shock
N8E86_08480	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
N8E86_08490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
N8E86_08495	COG5007	Belongs to the BolA IbaG family
N8E86_08500	COG3113	response to antibiotic
N8E86_08505	COG2854	intermembrane phospholipid transfer
N8E86_08510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N8E86_08515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N8E86_08520	COG1127	ABC transporter
N8E86_08530	COG3117	lipopolysaccharide transmembrane transporter activity
N8E86_08535	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
N8E86_08540	COG1137	ATPase activity
N8E86_08545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N8E86_08560	COG2186	Transcriptional regulator
N8E86_08575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N8E86_08590	COG1028	Short-chain dehydrogenase reductase Sdr
N8E86_08625	COG3676	manually curated
N8E86_08630	COG0753	catalase activity
N8E86_08635	COG0081	regulation of translation
N8E86_08640	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N8E86_08655	COG0252	asparaginase activity
N8E86_08660	COG3676	manually curated
N8E86_08680	COG2267	carboxylic ester hydrolase activity
N8E86_08695	COG0436	Aminotransferase
N8E86_08715	COG0861	Integral membrane protein TerC family
N8E86_08725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N8E86_08740	COG2860	membrane
N8E86_08750	COG0527	aspartate kinase activity
N8E86_08755	COG2897	thiosulfate sulfurtransferase activity
N8E86_08760	COG2391	methyltransferase activity
N8E86_08765	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N8E86_08780	COG3684	Belongs to the aldolase LacD family
N8E86_08785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
N8E86_08790	COG1349	DNA-binding transcription factor activity
N8E86_08800	COG3119	arylsulfatase activity
N8E86_08805	COG0641	radical SAM
N8E86_08820	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
N8E86_08820	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N8E86_08825	COG3716	PTS system mannose fructose sorbose family IID component
N8E86_08830	COG3715	PTS system
N8E86_08835	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
N8E86_08840	COG2222	sugar isomerase
N8E86_08850	COG3119	arylsulfatase activity
N8E86_08860	COG1028	Short-chain dehydrogenase reductase Sdr
N8E86_08870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N8E86_08875	COG0800	Aldolase
N8E86_08880	COG0584	glycerophosphoryl diester phosphodiesterase
N8E86_08885	COG3842	ATPase activity
N8E86_08895	COG1177	transmembrane transport
N8E86_08915	COG3077	Addiction module antitoxin, RelB DinJ family
N8E86_08920	COG2026	Addiction module toxin, RelE StbE family
N8E86_08930	COG1509	lysine 2,3-aminomutase activity
N8E86_08935	COG3266	domain, Protein
N8E86_08935	COG3061	Opacity-associated protein A
N8E86_08950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N8E86_08955	COG2814	Major facilitator Superfamily
N8E86_08960	COG4974	Belongs to the 'phage' integrase family
N8E86_08965	COG1605	Chorismate mutase
N8E86_08965	COG0077	Prephenate dehydratase
N8E86_08970	COG0604	alcohol dehydrogenase
N8E86_08970	COG1028	Short-chain dehydrogenase reductase Sdr
N8E86_08970	COG3321	synthase
N8E86_08975	COG4221	oxidoreductase activity
N8E86_08990	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
N8E86_08995	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N8E86_09000	COG0849	cell division
N8E86_09005	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
N8E86_09030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N8E86_09040	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
N8E86_09050	COG0768	penicillin binding
N8E86_09055	COG3116	cell division
N8E86_09075	COG1444	tRNA N-acetyltransferase activity
N8E86_09080	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
N8E86_09085	COG1702	phosphate starvation-inducible protein PhoH
N8E86_09095	COG0204	Acyl-transferase
N8E86_09105	COG0121	glutamine amidotransferase
N8E86_09110	COG0814	amino acid
N8E86_09115	COG1760	l-serine dehydratase
N8E86_09120	COG1138	Cytochrome C-type biogenesis protein
N8E86_09130	COG4235	cytochrome complex assembly
N8E86_09130	COG3088	subunit of a heme lyase
N8E86_09135	COG3088	subunit of a heme lyase
N8E86_09135	COG4235	cytochrome complex assembly
N8E86_09140	COG2081	HI0933 family
N8E86_09150	COG3301	Polysulphide reductase, NrfD
N8E86_09155	COG0437	4 iron, 4 sulfur cluster binding
N8E86_09160	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
N8E86_09165	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
N8E86_09185	COG1686	Belongs to the peptidase S11 family
N8E86_09195	COG0772	Belongs to the SEDS family
N8E86_09200	COG0768	penicillin binding
N8E86_09210	COG0799	negative regulation of ribosome biogenesis
N8E86_09215	COG0513	Belongs to the DEAD box helicase family
N8E86_09220	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N8E86_09250	COG3842	ATPase activity
N8E86_09285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N8E86_09290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N8E86_09300	COG0194	GDP metabolic process
N8E86_09305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N8E86_09310	COG0545	Peptidyl-prolyl cis-trans isomerase
N8E86_09325	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N8E86_09335	COG2830	Protein of unknown function (DUF452)
N8E86_09340	COG0500	methyltransferase
N8E86_09345	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N8E86_09350	COG1399	metal-binding, possibly nucleic acid-binding protein
N8E86_09360	COG0416	fatty acid biosynthetic process
N8E86_09365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N8E86_09370	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N8E86_09375	COG1028	Short-chain dehydrogenase reductase Sdr
N8E86_09385	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N8E86_09395	COG0656	L-ascorbic acid biosynthetic process
N8E86_09405	COG2801	Transposase and inactivated derivatives
N8E86_09410	COG2801	Transposase and inactivated derivatives
N8E86_09440	COG1077	Cell shape determining protein MreB Mrl
N8E86_09445	COG1792	Involved in formation and maintenance of cell shape
N8E86_09450	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
N8E86_09455	COG0748	coenzyme F420 binding
N8E86_09460	COG3721	Heme iron utilization protein
N8E86_09465	COG4771	TonB-dependent receptor
N8E86_09485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N8E86_09495	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
N8E86_09505	COG2731	YhcH YjgK YiaL family protein
N8E86_09510	COG1737	Transcriptional regulator
N8E86_09520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
N8E86_09540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
N8E86_09565	COG1172	Belongs to the binding-protein-dependent transport system permease family
N8E86_09570	COG1129	ABC transporter
N8E86_09580	COG1879	ABC-type sugar transport system periplasmic component
N8E86_09585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N8E86_09590	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N8E86_09595	COG0006	proline dipeptidase activity
N8E86_09615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
N8E86_09620	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
N8E86_09625	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N8E86_09630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
N8E86_09635	COG1720	tRNA m6t6A37 methyltransferase activity
N8E86_09640	COG1575	Belongs to the MenA family. Type 1 subfamily
N8E86_09645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
N8E86_09650	COG0471	metal ion transport
N8E86_09655	COG2226	methyltransferase
N8E86_09665	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
N8E86_09675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N8E86_09680	COG0805	protein transport
N8E86_09690	COG0084	hydrolase, TatD family'
N8E86_09695	COG0602	queuosine metabolic process
N8E86_09700	COG1328	CTP reductase activity
N8E86_09700	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
N8E86_09705	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N8E86_09720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N8E86_09755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N8E86_09760	COG0494	nUDIX hydrolase
N8E86_09765	COG0653	protein targeting
N8E86_09775	COG4701	Protein of unknown function (DUF721)
N8E86_09780	COG0338	D12 class N6 adenine-specific DNA methyltransferase
N8E86_09785	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
N8E86_09795	COG4796	Type ii and iii secretion system protein
N8E86_09815	COG4972	Pilus assembly protein
N8E86_09820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
N8E86_09845	COG4804	nuclease activity
N8E86_09850	COG4545	Glutaredoxin-related protein
N8E86_09855	COG0752	glycyl-tRNA synthetase alpha subunit
N8E86_09885	COG0582	viral genome integration into host DNA
N8E86_09910	COG3617	BRO family, N-terminal domain
N8E86_10075	COG3676	manually curated
N8E86_10085	COG0305	Participates in initiation and elongation during chromosome replication
N8E86_10135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N8E86_10135	COG0784	Response regulator, receiver
N8E86_10195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
N8E86_10205	COG0512	Glutamine amidotransferase of anthranilate synthase
N8E86_10210	COG0783	Belongs to the Dps family
N8E86_10240	COG0196	riboflavin kinase activity
N8E86_10270	COG0642	Histidine kinase
N8E86_10280	COG0165	Argininosuccinate lyase
N8E86_10285	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N8E86_10355	COG1598	PFAM Uncharacterised protein family UPF0150
N8E86_10390	COG0640	Transcriptional regulator
N8E86_10405	COG0786	glutamate:sodium symporter activity
N8E86_10635	COG4453	Protein conserved in bacteria
N8E86_10655	COG3621	Patatin-like phospholipase
N8E86_10710	COG0598	Magnesium transport protein CorA
N8E86_10715	COG0762	integral membrane protein
N8E86_10725	COG2177	Part of the ABC transporter FtsEX involved in
N8E86_10730	COG2884	Cell division ATP-binding protein ftsE
N8E86_10735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N8E86_10740	COG0235	Class ii aldolase
N8E86_10745	COG3623	hexulose-6-phosphate isomerase
N8E86_10755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
N8E86_10760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
N8E86_10765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
N8E86_10770	COG2731	YhcH YjgK YiaL family protein
N8E86_10775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
N8E86_10780	COG1414	Transcriptional regulator
N8E86_10790	COG1295	ribonuclease BN
N8E86_10795	COG1490	D-aminoacyl-tRNA deacylase activity
N8E86_10800	COG2197	response regulator
N8E86_10810	COG0181	hydroxymethylbilane synthase activity
N8E86_10820	COG2959	enzyme of heme biosynthesis
N8E86_10825	COG3071	HemY protein
N8E86_10830	COG3787	Belongs to the UPF0306 family
N8E86_10835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
N8E86_10840	COG0076	glutamate decarboxylase activity
N8E86_10845	COG0606	chelatase, subunit chli
N8E86_10850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N8E86_10855	COG3171	Protein conserved in bacteria
N8E86_10860	COG1921	L-seryl-tRNASec selenium transferase activity
N8E86_10865	COG3276	selenocysteine insertion sequence binding
N8E86_10875	COG1530	ribonuclease E activity
N8E86_10885	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N8E86_10895	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
N8E86_10925	COG0511	ligase activity, forming carbon-carbon bonds
N8E86_10930	COG0439	Biotin carboxylase
N8E86_10935	COG3924	membrane
N8E86_10940	COG4145	pantothenate transmembrane transporter activity
N8E86_10960	COG0538	isocitrate dehydrogenase activity
N8E86_10975	COG3477	response to acidic pH
N8E86_10980	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
N8E86_10985	COG2818	Glycosylase
N8E86_10990	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
N8E86_11000	COG3021	interspecies interaction between organisms
N8E86_11010	COG1522	sequence-specific DNA binding
N8E86_11020	COG1476	TRANSCRIPTIONal
N8E86_11045	COG1126	abc transporter atp-binding protein
N8E86_11050	COG0765	amino acid transport
N8E86_11055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N8E86_11060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N8E86_11070	COG3078	GTPase activator activity
N8E86_11075	COG0564	pseudouridine synthase activity
N8E86_11085	COG3201	nicotinamide mononucleotide transporter
N8E86_11090	COG0673	inositol 2-dehydrogenase activity
N8E86_11100	COG3718	enzyme involved in inositol metabolism
N8E86_11105	COG1940	carbohydrate kinase activity
N8E86_11115	COG0456	acetyltransferase
N8E86_11140	COG0738	Major facilitator superfamily
N8E86_11145	COG0235	Class ii aldolase
N8E86_11155	COG1070	Carbohydrate kinase
N8E86_11160	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
N8E86_11165	COG1349	DNA-binding transcription factor activity
N8E86_11175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N8E86_11180	COG0859	PFAM glycosyl transferase family 9
N8E86_11185	COG0859	PFAM glycosyl transferase family 9
N8E86_11220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N8E86_11235	COG3691	Protein conserved in bacteria
N8E86_11240	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
N8E86_11245	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
N8E86_11250	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
N8E86_11255	COG0363	glucosamine-6-phosphate deaminase activity
N8E86_11260	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
N8E86_11265	COG1218	3'(2'),5'-bisphosphate nucleotidase
N8E86_11270	COG1297	OPT oligopeptide transporter protein
N8E86_11275	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N8E86_11280	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
N8E86_11295	COG0051	transcription antitermination factor activity, RNA binding
N8E86_11305	COG0088	Forms part of the polypeptide exit tunnel
N8E86_11315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N8E86_11320	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N8E86_11330	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N8E86_11355	COG0582	viral genome integration into host DNA
N8E86_11425	COG3728	DNA packaging
N8E86_11495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N8E86_11500	COG0594	ribonuclease P activity