locus-tag	class	description
VY92_000010	COG0594	ribonuclease P activity
VY92_000020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VY92_000025	COG0592	DNA-directed DNA polymerase activity
VY92_000035	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VY92_000040	COG1381	Involved in DNA repair and RecF pathway recombination
VY92_000045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VY92_000050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VY92_000055	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VY92_000060	COG0252	asparaginase activity
VY92_000070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VY92_000090	COG3133	Outer membrane lipoprotein
VY92_000095	COG3962	Belongs to the TPP enzyme family
VY92_000105	COG0673	inositol 2-dehydrogenase activity
VY92_000115	COG0431	NADPH-dependent FMN reductase
VY92_000125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VY92_000130	COG1216	Glycosyl transferase, family 2
VY92_000135	COG3307	-O-antigen
VY92_000140	COG2976	Protein conserved in bacteria
VY92_000150	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VY92_000155	COG1426	Protein conserved in bacteria
VY92_000160	COG0490	domain, Protein
VY92_000160	COG0471	metal ion transport
VY92_000165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VY92_000175	COG4589	Belongs to the CDS family
VY92_000180	COG0521	Mo-molybdopterin cofactor biosynthetic process
VY92_000190	COG0628	permease
VY92_000200	COG3063	Type IV pilus biogenesis stability protein PilW
VY92_000205	COG0758	DNA mediated transformation
VY92_000210	COG0742	ribosomal rna small subunit methyltransferase
VY92_000215	COG0552	protein localization to endoplasmic reticulum
VY92_000220	COG0584	glycerophosphoryl diester phosphodiesterase
VY92_000225	COG2271	Major facilitator Superfamily
VY92_000230	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VY92_000240	COG0247	lactate metabolic process
VY92_000245	COG1349	DNA-binding transcription factor activity
VY92_000250	COG0705	Rhomboid family
VY92_000260	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
VY92_000270	COG0546	phosphoglycolate phosphatase activity
VY92_000275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VY92_000285	COG0251	oxidation-reduction process
VY92_000305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VY92_000315	COG0512	Glutamine amidotransferase of anthranilate synthase
VY92_000320	COG0783	Belongs to the Dps family
VY92_000335	COG0196	riboflavin kinase activity
VY92_000360	COG0745	RESPONSE REGULATOR receiver
VY92_000365	COG0642	Histidine kinase
VY92_000380	COG0165	Argininosuccinate lyase
VY92_000385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VY92_000545	COG3566	protein conserved in bacteria
VY92_000555	COG2369	cell adhesion
VY92_000560	COG3567	Phage-associated protein, HI1409 family
VY92_000565	COG1783	phage Terminase large subunit
VY92_000570	COG3728	DNA packaging
VY92_000620	COG3617	BRO family, N-terminal domain
VY92_000635	COG1846	Transcriptional regulator
VY92_000660	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VY92_000730	COG3617	BRO family, N-terminal domain
VY92_000745	COG1846	Transcriptional regulator
VY92_000810	COG3728	DNA packaging
VY92_000815	COG1783	phage Terminase large subunit
VY92_000900	COG1598	PFAM Uncharacterised protein family UPF0150
VY92_001095	COG4695	Portal protein
VY92_001170	COG4974	Belongs to the 'phage' integrase family
VY92_001175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VY92_001180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VY92_001185	COG0720	synthase
VY92_001190	COG0602	queuosine metabolic process
VY92_001220	COG1215	transferase activity, transferring glycosyl groups
VY92_001265	COG1793	dna ligase
VY92_001270	COG0363	glucosamine-6-phosphate deaminase activity
VY92_001275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VY92_001280	COG0590	tRNA wobble adenosine to inosine editing
VY92_001295	COG0730	response to heat
VY92_001300	COG0494	nUDIX hydrolase
VY92_001310	COG3023	N-Acetylmuramoyl-L-alanine amidase
VY92_001315	COG4969	Belongs to the N-Me-Phe pilin family
VY92_001320	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VY92_001325	COG0528	UMP kinase activity
VY92_001345	COG0575	Belongs to the CDS family
VY92_001350	COG0750	zinc metalloprotease
VY92_001360	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
VY92_001365	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
VY92_001370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VY92_001385	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VY92_001395	COG1466	dna polymerase III delta subunit
VY92_001400	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
VY92_001405	COG0495	leucyl-tRNA aminoacylation
VY92_001425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VY92_001430	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
VY92_001435	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VY92_001470	COG0328	RNA-DNA hybrid ribonuclease activity
VY92_001485	COG3716	PTS system mannose fructose sorbose family IID component
VY92_001490	COG3715	PTS system
VY92_001495	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY92_001495	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VY92_001500	COG1459	type II secretion system
VY92_001510	COG0237	dephospho-CoA kinase activity
VY92_001510	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
VY92_001520	COG1115	amino acid carrier protein
VY92_001525	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VY92_001530	COG1917	Cupin 2, conserved barrel domain protein
VY92_001530	COG4977	sequence-specific DNA binding
VY92_001535	COG5413	integral membrane protein
VY92_001545	COG4178	(ABC) transporter
VY92_001555	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VY92_001570	COG1454	alcohol dehydrogenase
VY92_001570	COG1012	belongs to the aldehyde dehydrogenase family
VY92_001575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VY92_001580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VY92_001590	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
VY92_001595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VY92_001600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VY92_001605	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VY92_001640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VY92_001650	COG2990	Protein conserved in bacteria
VY92_001655	COG0612	Peptidase, M16
VY92_001660	COG4771	TonB-dependent receptor
VY92_001670	COG0539	negative regulation of cytoplasmic translation
VY92_001675	COG0776	regulation of translation
VY92_001680	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
VY92_001685	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
VY92_001695	COG0023	Translation Initiation Factor
VY92_001715	COG0745	RESPONSE REGULATOR receiver
VY92_001720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VY92_001725	COG0151	Belongs to the GarS family
VY92_001740	COG2259	Doxx family
VY92_001745	COG5295	Hep Hag repeat protein
VY92_001760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VY92_001765	COG4172	Belongs to the ABC transporter superfamily
VY92_001770	COG4172	Belongs to the ABC transporter superfamily
VY92_001775	COG4171	peptide transport system, permease
VY92_001780	COG4168	peptide transport system, permease
VY92_001785	COG4166	transmembrane transport
VY92_001790	COG3106	COG3106 Predicted ATPase
VY92_001800	COG3283	Transcriptional regulator of aromatic amino acids metabolism
VY92_001815	COG0012	GTP binding
VY92_001825	COG2867	negative regulation of translational initiation
VY92_001835	COG2850	peptidyl-arginine hydroxylation
VY92_001850	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
VY92_001855	COG0739	heme binding
VY92_001865	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VY92_001870	COG0443	Heat shock 70 kDa protein
VY92_001875	COG0484	heat shock protein binding
VY92_001885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VY92_001890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VY92_001895	COG1643	Atp-dependent helicase
VY92_001905	COG0471	metal ion transport
VY92_001915	COG0583	DNA-binding transcription factor activity
VY92_001920	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
VY92_001925	COG1687	branched-chain amino acid
VY92_001945	COG2864	formate dehydrogenase
VY92_001950	COG0437	4 iron, 4 sulfur cluster binding
VY92_001975	COG0531	amino acid
VY92_001980	COG1982	Orn Lys Arg decarboxylase major
VY92_002060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VY92_002070	COG3021	interspecies interaction between organisms
VY92_002075	COG0251	oxidation-reduction process
VY92_002100	COG0270	DNA (cytosine-5-)-methyltransferase activity
VY92_002140	COG2974	May be involved in recombination
VY92_002215	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VY92_002240	COG1484	DNA-dependent DNA replication
VY92_002430	COG3179	chitinase
VY92_002455	COG3646	Phage regulatory protein
VY92_002490	COG0582	viral genome integration into host DNA
VY92_002495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VY92_002495	COG0519	Catalyzes the synthesis of GMP from XMP
VY92_002510	COG0516	GMP reductase activity
VY92_002510	COG0517	IMP dehydrogenase activity
VY92_002515	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
VY92_002515	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
VY92_002525	COG3422	double-strand break repair
VY92_002540	COG0134	indole-3-glycerol-phosphate synthase activity
VY92_002540	COG0135	phosphoribosylanthranilate isomerase activity
VY92_002545	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VY92_002550	COG1942	4-Oxalocrotonate Tautomerase
VY92_002555	COG0512	Glutamine amidotransferase of anthranilate synthase
VY92_002560	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VY92_002570	COG2927	DNA polymerase III (CHI subunit)
VY92_002575	COG2153	protein acetylation
VY92_002585	COG4185	zeta toxin
VY92_002600	COG0525	valine-tRNA ligase activity
VY92_002605	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VY92_002610	COG2249	NAD(P)H dehydrogenase (quinone) activity
VY92_002625	COG2814	Major facilitator Superfamily
VY92_002645	COG4221	oxidoreductase activity
VY92_002660	COG3094	Invasion gene expression up-regulator, SirB
VY92_002665	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VY92_002675	COG0735	belongs to the Fur family
VY92_002680	COG0716	FMN binding
VY92_002690	COG0596	Alpha beta hydrolase
VY92_002695	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
VY92_002700	COG0318	PFAM AMP-dependent synthetase and ligase
VY92_002705	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
VY92_002705	COG3264	Mechanosensitive ion channel
VY92_002715	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
VY92_002720	COG0730	response to heat
VY92_002725	COG1560	Kdo2-lipid A biosynthetic process
VY92_002730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VY92_002735	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VY92_002740	COG1966	Carbon starvation protein
VY92_002745	COG0673	inositol 2-dehydrogenase activity
VY92_002750	COG2186	Transcriptional regulator
VY92_002755	COG3842	ATPase activity
VY92_002765	COG1175	transmembrane transport
VY92_002775	COG0673	inositol 2-dehydrogenase activity
VY92_002785	COG0281	malic enzyme
VY92_002790	COG1733	regulation of RNA biosynthetic process
VY92_002800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
VY92_002805	COG1177	transmembrane transport
VY92_002810	COG1176	ABC-type spermidine putrescine transport system, permease component I
VY92_002815	COG3842	ATPase activity
VY92_002825	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
VY92_002830	COG4143	(ABC) transporter
VY92_002835	COG1178	ABC-type Fe3 transport system permease component
VY92_002840	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
VY92_002850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VY92_002855	COG0730	response to heat
VY92_002870	COG0786	glutamate:sodium symporter activity
VY92_002875	COG2005	Transcriptional regulator
VY92_002880	COG0725	ABC transporter, periplasmic molybdate-binding protein
VY92_002885	COG4149	molybdate abc transporter
VY92_002890	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
VY92_002900	COG3102	Protein conserved in bacteria
VY92_002905	COG0305	Participates in initiation and elongation during chromosome replication
VY92_002925	COG2932	Transcriptional regulator
VY92_002960	COG3077	Addiction module antitoxin, RelB DinJ family
VY92_002965	COG3041	Addiction module toxin RelE StbE family
VY92_002975	COG0494	nUDIX hydrolase
VY92_003000	COG1929	Belongs to the glycerate kinase type-1 family
VY92_003005	COG2610	gluconate transmembrane transporter activity
VY92_003010	COG3835	regulator
VY92_003015	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VY92_003020	COG1448	Aminotransferase
VY92_003025	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VY92_003030	COG0288	reversible hydration of carbon dioxide
VY92_003035	COG0306	phosphate transporter
VY92_003040	COG1392	Phosphate transport regulator
VY92_003045	COG3025	triphosphatase activity
VY92_003050	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VY92_003055	COG3468	outer membrane autotransporter barrel domain protein
VY92_003055	COG3266	domain, Protein
VY92_003065	COG0352	thiamine-phosphate diphosphorylase activity
VY92_003070	COG0351	phosphomethylpyrimidine kinase
VY92_003080	COG0658	competence protein
VY92_003080	COG2333	competence protein COMEC
VY92_003085	COG1132	(ABC) transporter
VY92_003090	COG1663	tetraacyldisaccharide 4'-kinase activity
VY92_003095	COG2835	tetraacyldisaccharide 4'-kinase activity
VY92_003100	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
VY92_003105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VY92_003110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VY92_003115	COG1116	anion transmembrane transporter activity
VY92_003120	COG0322	excinuclease ABC activity
VY92_003125	COG0586	Pfam SNARE associated Golgi protein
VY92_003130	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VY92_003135	COG0673	inositol 2-dehydrogenase activity
VY92_003145	COG0307	riboflavin synthase, alpha
VY92_003175	COG0671	phosphoesterase, PA-phosphatase related
VY92_003180	COG1940	carbohydrate kinase activity
VY92_003195	COG1115	amino acid carrier protein
VY92_003200	COG0515	serine threonine protein kinase
VY92_003215	COG0195	Participates in both transcription termination and antitermination
VY92_003220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VY92_003230	COG1566	PFAM secretion protein HlyD family protein
VY92_003250	COG2350	Protein conserved in bacteria
VY92_003255	COG1607	acyl-coa hydrolase
VY92_003270	COG3047	cAMP biosynthetic process
VY92_003285	COG0247	lactate metabolic process
VY92_003285	COG0277	FAD linked oxidase domain protein
VY92_003295	COG1704	LemA family
VY92_003340	COG4991	sh3 domain protein
VY92_003345	COG0617	tRNA 3'-terminal CCA addition
VY92_003350	COG3955	Domain of unknown function (DUF1919)
VY92_003355	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VY92_003360	COG1984	allophanate hydrolase subunit 2
VY92_003365	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VY92_003370	COG1914	H( )-stimulated, divalent metal cation uptake system
VY92_003385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VY92_003395	COG0708	Exodeoxyribonuclease III
VY92_003410	COG0616	signal peptide processing
VY92_003415	COG1840	ABC-type Fe3 transport system, periplasmic component
VY92_003420	COG1408	metallophosphoesterase
VY92_003425	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VY92_003430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
VY92_003435	COG2863	cytochrome
VY92_003445	COG1199	ATP-dependent helicase activity
VY92_003450	COG1214	PFAM Peptidase M22, glycoprotease
VY92_003455	COG0318	PFAM AMP-dependent synthetase and ligase
VY92_003460	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
VY92_003475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VY92_003480	COG4988	ABC transporter
VY92_003485	COG0492	ferredoxin-NADP+ reductase activity
VY92_003490	COG3118	belongs to the thioredoxin family
VY92_003495	COG2610	gluconate transmembrane transporter activity
VY92_003500	COG3265	gluconokinase activity
VY92_003510	COG0733	neurotransmitter:sodium symporter activity
VY92_003515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VY92_003530	COG4658	electron transport chain
VY92_003535	COG4656	Part of a membrane complex involved in electron transport
VY92_003545	COG4657	Part of a membrane complex involved in electron transport
VY92_003550	COG1090	epimerase
VY92_003555	COG1438	arginine binding
VY92_003560	COG0039	L-malate dehydrogenase activity
VY92_003570	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
VY92_003575	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VY92_003575	COG0517	IMP dehydrogenase activity
VY92_003605	COG0285	dihydrofolate synthase activity
VY92_003610	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VY92_003615	COG3140	Belongs to the UPF0181 family
VY92_003620	COG1278	Cold shock
VY92_003635	COG1609	Transcriptional regulator
VY92_003650	COG1067	ATP-dependent peptidase activity
VY92_003660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VY92_003665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VY92_003670	COG2252	PERMEase
VY92_003675	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
VY92_003680	COG1074	ATP-dependent DNA helicase activity
VY92_003685	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VY92_003700	COG1940	carbohydrate kinase activity
VY92_003700	COG1846	Transcriptional regulator
VY92_003710	COG0788	formyltetrahydrofolate deformylase activity
VY92_003715	COG0406	alpha-ribazole phosphatase activity
VY92_003725	COG0564	pseudouridine synthase activity
VY92_003740	COG0776	regulation of translation
VY92_003745	COG0791	NLP P60 protein
VY92_003780	COG0697	spore germination
VY92_003785	COG2925	Exonuclease
VY92_003800	COG3676	manually curated
VY92_003805	COG2969	positive regulation of protein catabolic process
VY92_003830	COG3098	single-species biofilm formation
VY92_003835	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
VY92_003850	COG1611	Belongs to the LOG family
VY92_003855	COG4453	Protein conserved in bacteria
VY92_003865	COG1215	transferase activity, transferring glycosyl groups
VY92_003870	COG0842	Transport permease protein
VY92_003875	COG1131	(ABC) transporter
VY92_003880	COG3101	peptidyl-lysine hydroxylation
VY92_003890	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VY92_003910	COG1523	belongs to the glycosyl hydrolase 13 family
VY92_003915	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
VY92_003920	COG1640	4-alpha-glucanotransferase
VY92_003925	COG3152	Membrane
VY92_003945	COG0577	efflux transmembrane transporter activity
VY92_003945	COG1136	(ABC) transporter
VY92_003950	COG1538	Outer membrane efflux protein
VY92_003960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VY92_003965	COG0508	dehydrogenase complex catalyzes the overall conversion of
VY92_003970	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
VY92_003975	COG2190	(PTS) system
VY92_003980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VY92_003985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY92_003990	COG1162	GTPase activity
VY92_003995	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
VY92_004015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VY92_004020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VY92_004045	COG1522	sequence-specific DNA binding
VY92_004055	COG1346	cytolysis
VY92_004060	COG1380	Effector of murein hydrolase LrgA
VY92_004065	COG1525	nuclease
VY92_004075	COG2166	iron-sulfur cluster assembly
VY92_004080	COG2268	Band 7 protein
VY92_004095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VY92_004100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VY92_004100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VY92_004110	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VY92_004115	COG0617	tRNA 3'-terminal CCA addition
VY92_004120	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VY92_004125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VY92_004125	COG0301	tRNA thio-modification
VY92_004135	COG0142	geranyltranstransferase activity
VY92_004145	COG1534	Rna-binding protein
VY92_004155	COG0633	Ferredoxin
VY92_004155	COG3217	Mosc domain protein beta barrel domain protein
VY92_004165	COG0287	Prephenate dehydrogenase
VY92_004165	COG1605	Chorismate mutase
VY92_004170	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VY92_004175	COG0613	PHP domain protein
VY92_004180	COG0167	dihydroorotate dehydrogenase activity
VY92_004185	COG0308	aminopeptidase N
VY92_004190	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VY92_004235	COG0163	prenyltransferase activity
VY92_004245	COG1286	toxin biosynthetic process
VY92_004250	COG3092	negative regulation of chromosome organization
VY92_004260	COG0280	phosphate acetyltransferase
VY92_004260	COG0857	belongs to the CobB CobQ family
VY92_004285	COG0668	transmembrane transport
VY92_004290	COG0795	lipopolysaccharide-transporting ATPase activity
VY92_004295	COG0795	lipopolysaccharide-transporting ATPase activity
VY92_004320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VY92_004325	COG2226	methyltransferase
VY92_004330	COG1944	ATP diphosphatase activity
VY92_004335	COG3105	Protein conserved in bacteria
VY92_004340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VY92_004355	COG0633	Ferredoxin
VY92_004365	COG1280	lysine exporter protein (LysE YggA)
VY92_004370	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VY92_004375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VY92_004380	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VY92_004390	COG0814	amino acid
VY92_004400	COG2062	phosphohistidine phosphatase, SixA
VY92_004410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VY92_004420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VY92_004425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VY92_004425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VY92_004430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VY92_004470	COG2999	glutathione oxidoreductase activity
VY92_004505	COG1476	TRANSCRIPTIONal
VY92_004510	COG0582	viral genome integration into host DNA
VY92_004530	COG3306	glycosyltransferase involved in LPS biosynthesis
VY92_004535	COG3306	glycosyltransferase involved in LPS biosynthesis
VY92_004555	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
VY92_004560	COG3683	transport system, periplasmic component
VY92_004565	COG0488	(ABC) transporter
VY92_004570	COG2195	Cleaves the N-terminal amino acid of tripeptides
VY92_004585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VY92_004590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VY92_004595	COG1957	nucleoside hydrolase
VY92_004600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VY92_004605	COG0670	Belongs to the BI1 family
VY92_004610	COG2920	part of a sulfur-relay system
VY92_004620	COG1121	(ABC) transporter
VY92_004625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VY92_004630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VY92_004635	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VY92_004640	COG2949	membrane
VY92_004650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
VY92_004655	COG4591	ABC-type transport system involved in lipoprotein release permease component
VY92_004660	COG1136	(ABC) transporter
VY92_004665	COG4591	ABC-type transport system involved in lipoprotein release permease component
VY92_004670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VY92_004690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VY92_004700	COG1289	transmembrane transporter activity
VY92_004715	COG0314	molybdopterin synthase activity
VY92_004720	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VY92_004725	COG0315	cyclic pyranopterin monophosphate synthase activity
VY92_004770	COG1696	Membrane protein involved in D-alanine export
VY92_004780	COG0303	'Molybdopterin
VY92_004785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VY92_004790	COG2431	L-lysine efflux transmembrane transporter activity
VY92_004795	COG1528	Iron-storage protein
VY92_004800	COG1528	Iron-storage protein
VY92_004810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VY92_004815	COG0589	response to stress
VY92_004825	COG2171	N-acyltransferase activity
VY92_004830	COG0583	DNA-binding transcription factor activity
VY92_004840	COG0009	L-threonylcarbamoyladenylate synthase
VY92_004855	COG0792	nuclease activity
VY92_004860	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
VY92_004865	COG2823	Periplasmic or secreted lipoprotein
VY92_004870	COG0210	DNA helicase
VY92_004890	COG0583	DNA-binding transcription factor activity
VY92_004895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VY92_004910	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VY92_004915	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VY92_004930	COG0626	cystathionine gamma-synthase activity
VY92_004935	COG0450	alkyl hydroperoxide reductase
VY92_004940	COG3100	YcgL domain-containing protein
VY92_004945	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VY92_004945	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
VY92_004950	COG1560	Kdo2-lipid A biosynthetic process
VY92_004955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VY92_004960	COG3108	Peptidase M15
VY92_004965	COG2989	Protein conserved in bacteria
VY92_004970	COG0793	Belongs to the peptidase S41A family
VY92_004975	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
VY92_004980	COG2995	paraquat-inducible protein a
VY92_004990	COG0187	DNA topoisomerase II activity
VY92_005005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VY92_005010	COG1328	CTP reductase activity
VY92_005015	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VY92_005040	COG0583	DNA-binding transcription factor activity
VY92_005045	COG0616	signal peptide processing
VY92_005050	COG0778	Nitroreductase
VY92_005070	COG0039	L-malate dehydrogenase activity
VY92_005075	COG0440	acetolactate synthase activity
VY92_005080	COG0028	Belongs to the TPP enzyme family
VY92_005085	COG1757	Na H antiporter
VY92_005100	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VY92_005125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VY92_005150	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VY92_005155	COG0494	nUDIX hydrolase
VY92_005165	COG1876	peptidase activity
VY92_005170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VY92_005175	COG1393	Belongs to the ArsC family
VY92_005195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VY92_005200	COG0083	homoserine kinase activity
VY92_005205	COG0460	homoserine dehydrogenase
VY92_005205	COG0527	aspartate kinase activity
VY92_005215	COG0346	lactoylglutathione lyase activity
VY92_005220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VY92_005225	COG2056	Na+-H+ antiporter family
VY92_005230	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
VY92_005230	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
VY92_005230	COG0506	proline dehydrogenase activity
VY92_005235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VY92_005250	COG3945	hemerythrin HHE cation binding domain
VY92_005255	COG1862	Preprotein translocase
VY92_005260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VY92_005265	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VY92_005270	COG0741	lytic transglycosylase activity
VY92_005285	COG4221	oxidoreductase activity
VY92_005290	COG2814	Major facilitator Superfamily
VY92_005315	COG3210	domain, Protein
VY92_005340	COG2189	Belongs to the N(4) N(6)-methyltransferase family
VY92_005350	COG0583	DNA-binding transcription factor activity
VY92_005355	COG0642	Histidine kinase
VY92_005360	COG0745	RESPONSE REGULATOR receiver
VY92_005365	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VY92_005375	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VY92_005380	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VY92_005390	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
VY92_005395	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
VY92_005410	COG3119	arylsulfatase activity
VY92_005420	COG2089	acid synthase
VY92_005435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VY92_005445	COG1621	beta-fructofuranosidase activity
VY92_005460	COG0802	atpase or kinase
VY92_005465	COG0860	N-Acetylmuramoyl-L-alanine amidase
VY92_005465	COG1388	LysM domain
VY92_005470	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VY92_005480	COG1923	regulation of RNA biosynthetic process
VY92_005485	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VY92_005495	COG3099	Belongs to the UPF0263 family
VY92_005520	COG4735	regulation of single-species biofilm formation
VY92_005560	COG2378	regulation of single-species biofilm formation
VY92_005575	COG1741	Belongs to the pirin family
VY92_005580	COG2951	lytic endotransglycosylase activity
VY92_005585	COG1216	Glycosyl transferase, family 2
VY92_005590	COG1216	Glycosyl transferase, family 2
VY92_005600	COG3306	glycosyltransferase involved in LPS biosynthesis
VY92_005610	COG5039	Polysaccharide pyruvyl transferase
VY92_005615	COG1434	Gram-negative-bacterium-type cell wall biogenesis
VY92_005620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VY92_005625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VY92_005625	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
VY92_005630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VY92_005630	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VY92_005635	COG0489	protein tyrosine kinase activity
VY92_005640	COG0672	)-iron permease
VY92_005655	COG1136	(ABC) transporter
VY92_005655	COG0577	efflux transmembrane transporter activity
VY92_005665	COG1136	(ABC) transporter
VY92_005670	COG0676	glucose-6-phosphate 1-epimerase activity
VY92_005685	COG3177	Filamentation induced by cAMP protein fic
VY92_005695	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VY92_005700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VY92_005705	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VY92_005710	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VY92_005710	COG2885	chlorophyll binding
VY92_005715	COG2824	Alkylphosphonate utilization operon protein PhnA
VY92_005720	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
VY92_005725	COG1120	ATPase activity
VY92_005745	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
VY92_005750	COG4774	siderophore transport
VY92_005755	COG4774	siderophore transport
VY92_005765	COG0814	amino acid
VY92_005770	COG2964	Protein conserved in bacteria
VY92_005780	COG0469	pyruvate kinase activity
VY92_005785	COG0778	Nitroreductase
VY92_005795	COG0037	tRNA processing
VY92_005800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VY92_005810	COG0508	dehydrogenase complex catalyzes the overall conversion of
VY92_005815	COG0567	Dehydrogenase, E1 component
VY92_005820	COG0372	Belongs to the citrate synthase family
VY92_005825	COG3381	protein complex oligomerization
VY92_005830	COG2249	NAD(P)H dehydrogenase (quinone) activity
VY92_005840	COG0330	HflC and HflK could
VY92_005870	COG1846	Transcriptional regulator
VY92_005870	COG1940	carbohydrate kinase activity
VY92_005885	COG0497	DNA recombination
VY92_005890	COG0360	Binds together with S18 to 16S ribosomal RNA
VY92_005895	COG2965	DNA replication, synthesis of RNA primer
VY92_005920	COG1530	ribonuclease E activity
VY92_005975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VY92_005985	COG0024	Methionine aminopeptidase
VY92_005990	COG0316	Belongs to the HesB IscA family
VY92_006000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VY92_006010	COG4166	transmembrane transport
VY92_006015	COG2832	Protein of unknown function (DUF454)
VY92_006020	COG0339	signal peptide processing
VY92_006025	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
VY92_006030	COG1053	succinate dehydrogenase
VY92_006035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VY92_006045	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
VY92_006055	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
VY92_006060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VY92_006065	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
VY92_006080	COG1278	Cold shock
VY92_006085	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VY92_006095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VY92_006100	COG5007	Belongs to the BolA IbaG family
VY92_006105	COG3113	response to antibiotic
VY92_006110	COG2854	intermembrane phospholipid transfer
VY92_006115	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
VY92_006120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
VY92_006125	COG1127	ABC transporter
VY92_006135	COG3117	lipopolysaccharide transmembrane transporter activity
VY92_006140	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
VY92_006145	COG1137	ATPase activity
VY92_006150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY92_006165	COG2186	Transcriptional regulator
VY92_006180	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VY92_006195	COG1028	Short-chain dehydrogenase reductase Sdr
VY92_006245	COG2267	carboxylic ester hydrolase activity
VY92_006260	COG0436	Aminotransferase
VY92_006280	COG0861	Integral membrane protein TerC family
VY92_006290	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VY92_006295	COG2067	long-chain fatty acid transport protein
VY92_006305	COG2860	membrane
VY92_006315	COG0527	aspartate kinase activity
VY92_006320	COG2897	thiosulfate sulfurtransferase activity
VY92_006325	COG2391	methyltransferase activity
VY92_006330	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VY92_006345	COG3684	Belongs to the aldolase LacD family
VY92_006350	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VY92_006355	COG1349	DNA-binding transcription factor activity
VY92_006365	COG3119	arylsulfatase activity
VY92_006370	COG0641	radical SAM
VY92_006380	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
VY92_006385	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY92_006385	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VY92_006390	COG3716	PTS system mannose fructose sorbose family IID component
VY92_006395	COG3715	PTS system
VY92_006400	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VY92_006405	COG2222	sugar isomerase
VY92_006415	COG3119	arylsulfatase activity
VY92_006425	COG1028	Short-chain dehydrogenase reductase Sdr
VY92_006435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VY92_006440	COG0800	Aldolase
VY92_006445	COG0584	glycerophosphoryl diester phosphodiesterase
VY92_006450	COG3842	ATPase activity
VY92_006460	COG1177	transmembrane transport
VY92_006485	COG1509	lysine 2,3-aminomutase activity
VY92_006490	COG3266	domain, Protein
VY92_006490	COG3061	Opacity-associated protein A
VY92_006500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VY92_006505	COG2814	Major facilitator Superfamily
VY92_006510	COG4974	Belongs to the 'phage' integrase family
VY92_006515	COG1605	Chorismate mutase
VY92_006515	COG0077	Prephenate dehydratase
VY92_006520	COG3321	synthase
VY92_006520	COG1028	Short-chain dehydrogenase reductase Sdr
VY92_006520	COG0604	alcohol dehydrogenase
VY92_006535	COG4221	oxidoreductase activity
VY92_006550	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
VY92_006555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VY92_006560	COG0849	cell division
VY92_006565	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VY92_006590	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VY92_006600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VY92_006610	COG0768	penicillin binding
VY92_006615	COG3116	cell division
VY92_006635	COG1444	tRNA N-acetyltransferase activity
VY92_006645	COG1702	phosphate starvation-inducible protein PhoH
VY92_006655	COG0204	Acyl-transferase
VY92_006665	COG0121	glutamine amidotransferase
VY92_006670	COG0814	amino acid
VY92_006675	COG1760	l-serine dehydratase
VY92_006680	COG1138	Cytochrome C-type biogenesis protein
VY92_006690	COG4235	cytochrome complex assembly
VY92_006690	COG3088	subunit of a heme lyase
VY92_006695	COG4235	cytochrome complex assembly
VY92_006695	COG3088	subunit of a heme lyase
VY92_006700	COG2081	HI0933 family
VY92_006710	COG3301	Polysulphide reductase, NrfD
VY92_006715	COG0437	4 iron, 4 sulfur cluster binding
VY92_006720	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VY92_006725	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
VY92_006745	COG1686	Belongs to the peptidase S11 family
VY92_006755	COG0772	Belongs to the SEDS family
VY92_006760	COG0768	penicillin binding
VY92_006770	COG0799	negative regulation of ribosome biogenesis
VY92_006775	COG0513	Belongs to the DEAD box helicase family
VY92_006780	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VY92_006810	COG3842	ATPase activity
VY92_006840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VY92_006845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VY92_006855	COG0194	GDP metabolic process
VY92_006860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VY92_006865	COG3676	manually curated
VY92_006870	COG0545	Peptidyl-prolyl cis-trans isomerase
VY92_006890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VY92_006900	COG2830	Protein of unknown function (DUF452)
VY92_006905	COG0500	methyltransferase
VY92_006910	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
VY92_006915	COG1399	metal-binding, possibly nucleic acid-binding protein
VY92_006925	COG0416	fatty acid biosynthetic process
VY92_006930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VY92_006935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VY92_006940	COG1028	Short-chain dehydrogenase reductase Sdr
VY92_006955	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VY92_006965	COG0656	L-ascorbic acid biosynthetic process
VY92_007040	COG1077	Cell shape determining protein MreB Mrl
VY92_007045	COG1792	Involved in formation and maintenance of cell shape
VY92_007050	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VY92_007055	COG0748	coenzyme F420 binding
VY92_007060	COG3721	Heme iron utilization protein
VY92_007065	COG4771	TonB-dependent receptor
VY92_007085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VY92_007095	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
VY92_007105	COG2731	YhcH YjgK YiaL family protein
VY92_007110	COG1737	Transcriptional regulator
VY92_007120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VY92_007140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VY92_007165	COG1172	Belongs to the binding-protein-dependent transport system permease family
VY92_007170	COG1129	ABC transporter
VY92_007180	COG1879	ABC-type sugar transport system periplasmic component
VY92_007185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VY92_007190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VY92_007195	COG0006	proline dipeptidase activity
VY92_007215	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VY92_007220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VY92_007225	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VY92_007230	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VY92_007235	COG1720	tRNA m6t6A37 methyltransferase activity
VY92_007245	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VY92_007250	COG0471	metal ion transport
VY92_007255	COG2226	methyltransferase
VY92_007265	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
VY92_007275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VY92_007280	COG0805	protein transport
VY92_007290	COG0084	hydrolase, TatD family'
VY92_007295	COG0602	queuosine metabolic process
VY92_007305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VY92_007320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VY92_007380	COG2026	Addiction module toxin, RelE StbE family
VY92_007410	COG0582	viral genome integration into host DNA
VY92_007435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VY92_007440	COG0494	nUDIX hydrolase
VY92_007455	COG4701	Protein of unknown function (DUF721)
VY92_007460	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VY92_007465	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VY92_007475	COG4796	Type ii and iii secretion system protein
VY92_007495	COG4972	Pilus assembly protein
VY92_007500	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
VY92_007505	COG3676	manually curated
VY92_007530	COG2852	Protein conserved in bacteria
VY92_007535	COG4804	nuclease activity
VY92_007545	COG4545	Glutaredoxin-related protein
VY92_007550	COG0752	glycyl-tRNA synthetase alpha subunit
VY92_007580	COG0582	viral genome integration into host DNA
VY92_007590	COG3617	BRO family, N-terminal domain
VY92_007615	COG0629	single-stranded DNA binding
VY92_007760	COG1846	Transcriptional regulator
VY92_007785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VY92_007860	COG2974	May be involved in recombination
VY92_007910	COG0582	viral genome integration into host DNA
VY92_007930	COG0626	cystathionine gamma-synthase activity
VY92_007935	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VY92_007945	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VY92_007950	COG0142	geranyltranstransferase activity
VY92_007965	COG0697	spore germination
VY92_008070	COG3210	domain, Protein
VY92_008070	COG3210	domain, Protein
VY92_008075	COG2831	hemolysin activation secretion protein
VY92_008085	COG1846	Transcriptional regulator
VY92_008100	COG1846	Transcriptional regulator
VY92_008105	COG1566	PFAM secretion protein HlyD family protein
VY92_008110	COG2814	Major facilitator Superfamily
VY92_008120	COG0557	exoribonuclease II activity
VY92_008140	COG0681	Belongs to the peptidase S26 family
VY92_008180	COG0105	UTP biosynthetic process
VY92_008200	COG0784	Response regulator, receiver
VY92_008200	COG2198	Histidine kinase
VY92_008200	COG5002	protein histidine kinase activity
VY92_008205	COG0385	Bile acid
VY92_008210	COG2814	Major facilitator Superfamily
VY92_008215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VY92_008225	COG2252	PERMEase
VY92_008230	COG1555	photosystem II stabilization
VY92_008235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VY92_008240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VY92_008250	COG1238	metal cluster binding
VY92_008255	COG0110	maltose O-acetyltransferase activity
VY92_008260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VY92_008285	COG1238	metal cluster binding
VY92_008305	COG4783	chaperone-mediated protein folding
VY92_008315	COG0814	amino acid
VY92_008320	COG2226	methyltransferase
VY92_008325	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VY92_008330	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VY92_008345	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
VY92_008345	COG0131	Imidazoleglycerol-phosphate dehydratase
VY92_008350	COG4804	nuclease activity
VY92_008360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VY92_008370	COG0107	imidazoleglycerol-phosphate synthase activity
VY92_008385	COG3161	chorismate lyase activity
VY92_008390	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VY92_008395	COG2233	PERMEase
VY92_008400	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VY92_008405	COG0066	3-isopropylmalate dehydratase activity
VY92_008410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VY92_008425	COG4133	protoheme IX ABC transporter activity
VY92_008430	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VY92_008435	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VY92_008440	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VY92_008450	COG1138	Cytochrome C-type biogenesis protein
VY92_008455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VY92_008470	COG4211	Belongs to the binding-protein-dependent transport system permease family
VY92_008475	COG1129	ABC transporter
VY92_008480	COG1879	ABC-type sugar transport system periplasmic component
VY92_008485	COG1085	galactose-1-phosphate uridylyltransferase
VY92_008495	COG2017	converts alpha-aldose to the beta-anomer
VY92_008505	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
VY92_008510	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
VY92_008515	COG1882	Formate acetyltransferase
VY92_008520	COG2116	formate transmembrane transporter activity
VY92_008525	COG0537	adenosine 5'-monophosphoramidase activity
VY92_008540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VY92_008555	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VY92_008560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VY92_008565	COG0254	rRNA binding
VY92_008570	COG1253	flavin adenine dinucleotide binding
VY92_008580	COG0084	hydrolase, TatD family'
VY92_008585	COG0470	DNA polymerase III
VY92_008590	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VY92_008595	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VY92_008605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VY92_008610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
VY92_008620	COG0330	HflC and HflK could
VY92_008625	COG0330	HflC and HflK could
VY92_008640	COG0326	Molecular chaperone. Has ATPase activity
VY92_008645	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
VY92_008650	COG3091	SprT-like family
VY92_008655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VY92_008660	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VY92_008700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VY92_008720	COG0210	DNA helicase
VY92_008725	COG5645	(Lipo)protein
VY92_008740	COG1447	Phosphotransferase system cellobiose-specific component IIA
VY92_008745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VY92_008750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VY92_008755	COG1446	asparaginase
VY92_008760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VY92_008770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VY92_008775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VY92_008800	COG2183	response to ionizing radiation
VY92_008805	COG1114	Component of the transport system for branched-chain amino acids
VY92_008810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VY92_008830	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
VY92_008835	COG0456	acetyltransferase
VY92_008840	COG1022	Amp-dependent synthetase and ligase
VY92_008845	COG1027	Aspartate ammonia-lyase
VY92_008855	COG0740	serine-type endopeptidase activity
VY92_008880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VY92_008885	COG3263	regulation of cellular component size
VY92_008890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VY92_008890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VY92_008900	COG3722	fumarate hydratase activity
VY92_008905	COG0246	Mannitol dehydrogenase
VY92_008920	COG0848	biopolymer transport protein
VY92_008925	COG0811	peptide transport
VY92_008930	COG4536	flavin adenine dinucleotide binding
VY92_008935	COG4137	Cytochrome C assembly protein
VY92_008940	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VY92_008950	COG3036	rescue of stalled ribosome
VY92_008955	COG1393	Belongs to the ArsC family
VY92_008965	COG1126	abc transporter atp-binding protein
VY92_008970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VY92_008975	COG4215	(ABC) transporter
VY92_008980	COG4160	amino acid transport
VY92_009005	COG0174	glutamine synthetase
VY92_009025	COG3306	glycosyltransferase involved in LPS biosynthesis
VY92_009040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VY92_009060	COG0312	modulator of DNA gyrase
VY92_009065	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
VY92_009075	COG1271	oxidase subunit
VY92_009080	COG1294	oxidase, subunit
VY92_009090	COG3790	cyd operon protein YbgE
VY92_009100	COG0824	Thioesterase
VY92_009105	COG0811	peptide transport
VY92_009110	COG0848	biopolymer transport protein
VY92_009115	COG3064	Membrane
VY92_009140	COG2165	general secretion pathway protein
VY92_009145	COG4795	General secretion pathway protein
VY92_009160	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
VY92_009165	COG0561	phosphatase activity
VY92_009170	COG0235	Class ii aldolase
VY92_009175	COG3623	hexulose-6-phosphate isomerase
VY92_009200	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VY92_009270	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
VY92_009275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VY92_009285	COG0425	Belongs to the sulfur carrier protein TusA family
VY92_009295	COG4942	peptidase
VY92_009300	COG2861	carbohydrate metabolic process
VY92_009305	COG1040	competence protein
VY92_009315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VY92_009330	COG3850	Histidine kinase
VY92_009335	COG3062	negative regulation of establishment of protein localization
VY92_009340	COG0243	molybdopterin cofactor binding
VY92_009345	COG0437	4 iron, 4 sulfur cluster binding
VY92_009350	COG0348	domain, Protein
VY92_009355	COG3043	anaerobic respiration
VY92_009360	COG3005	denitrification pathway
VY92_009370	COG4785	May be involved in cell division
VY92_009390	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
VY92_009395	COG0569	domain protein
VY92_009415	COG1252	NADH dehydrogenase
VY92_009420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VY92_009430	COG0191	fructose-bisphosphate aldolase activity
VY92_009435	COG0126	phosphoglycerate kinase activity
VY92_009440	COG3719	Belongs to the RNase T2 family
VY92_009445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
VY92_009450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VY92_009455	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VY92_009465	COG0778	Nitroreductase
VY92_009470	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
VY92_009475	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VY92_009490	COG1045	serine acetyltransferase
VY92_009495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VY92_009500	COG2194	sulfuric ester hydrolase activity
VY92_009505	COG0789	Transcriptional regulator
VY92_009520	COG0280	phosphate acetyltransferase
VY92_009520	COG0281	malic enzyme
VY92_009530	COG1368	sulfuric ester hydrolase activity
VY92_009535	COG0335	large ribosomal subunit rRNA binding
VY92_009545	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VY92_009550	COG0228	four-way junction DNA binding
VY92_009555	COG0859	PFAM glycosyl transferase family 9
VY92_009560	COG0463	Glycosyl transferase, family 2
VY92_009565	COG0561	phosphatase activity
VY92_009570	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VY92_009570	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY92_009575	COG3715	PTS system
VY92_009580	COG3716	PTS system mannose fructose sorbose family IID component
VY92_009595	COG0633	Ferredoxin
VY92_009600	COG0443	Heat shock 70 kDa protein
VY92_009610	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VY92_009620	COG0822	iron-sulfur transferase activity
VY92_009630	COG1959	2 iron, 2 sulfur cluster binding
VY92_009635	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
VY92_009650	COG2837	iron assimilation
VY92_009660	COG0513	Belongs to the DEAD box helicase family
VY92_009665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VY92_009675	COG2853	Lipoprotein
VY92_009700	COG0004	ammonium transporteR
VY92_009700	COG0004	ammonium transporteR
VY92_009705	COG3676	manually curated
VY92_009710	COG2990	Protein conserved in bacteria
VY92_009715	COG0433	COG0433 Predicted ATPase
VY92_009750	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
VY92_009755	COG0668	transmembrane transport
VY92_009760	COG0248	Ppx GppA phosphatase
VY92_009765	COG2911	Protein conserved in bacteria
VY92_009775	COG0728	peptidoglycan biosynthetic process
VY92_009780	COG0268	Binds directly to 16S ribosomal RNA
VY92_009790	COG0560	Phosphoserine phosphatase
VY92_009805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VY92_009810	COG3085	chromosome segregation
VY92_009815	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VY92_009820	COG3084	Protein conserved in bacteria
VY92_009830	COG0354	folic acid binding
VY92_009835	COG1561	YicC-like family, N-terminal region
VY92_009840	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VY92_009845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VY92_009850	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
VY92_009860	COG0402	S-adenosylhomocysteine deaminase activity
VY92_009865	COG3083	sulfuric ester hydrolase activity
VY92_009880	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
VY92_009885	COG0745	RESPONSE REGULATOR receiver
VY92_009890	COG1584	GPR1 FUN34 yaaH family protein
VY92_009895	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VY92_009900	COG0085	RNA polymerase activity
VY92_009915	COG0081	regulation of translation
VY92_009920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VY92_009945	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VY92_009950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VY92_009980	COG2923	Belongs to the DsrF TusC family
VY92_009995	COG0545	Peptidyl-prolyl cis-trans isomerase
VY92_010005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VY92_010005	COG0678	peroxiredoxin activity
VY92_010010	COG0583	DNA-binding transcription factor activity
VY92_010015	COG1309	transcriptional regulator
VY92_010020	COG2267	carboxylic ester hydrolase activity
VY92_010025	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VY92_010040	COG3978	acetolactate synthase activity
VY92_010070	COG1476	TRANSCRIPTIONal
VY92_010090	COG3021	interspecies interaction between organisms
VY92_010100	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
VY92_010105	COG2818	Glycosylase
VY92_010110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VY92_010115	COG3477	response to acidic pH
VY92_010130	COG0538	isocitrate dehydrogenase activity
VY92_010150	COG4145	pantothenate transmembrane transporter activity
VY92_010155	COG3924	membrane
VY92_010165	COG0439	Biotin carboxylase
VY92_010190	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VY92_010220	COG3276	selenocysteine insertion sequence binding
VY92_010230	COG3171	Protein conserved in bacteria
VY92_010235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VY92_010240	COG0606	chelatase, subunit chli
VY92_010245	COG0076	glutamate decarboxylase activity
VY92_010250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VY92_010255	COG3787	Belongs to the UPF0306 family
VY92_010260	COG3071	HemY protein
VY92_010265	COG2959	enzyme of heme biosynthesis
VY92_010275	COG0181	hydroxymethylbilane synthase activity
VY92_010285	COG2197	response regulator
VY92_010295	COG1295	ribonuclease BN
VY92_010305	COG1414	Transcriptional regulator
VY92_010310	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
VY92_010315	COG2731	YhcH YjgK YiaL family protein
VY92_010320	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
VY92_010325	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
VY92_010330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VY92_010340	COG3623	hexulose-6-phosphate isomerase
VY92_010345	COG0235	Class ii aldolase
VY92_010355	COG2884	Cell division ATP-binding protein ftsE
VY92_010360	COG2177	Part of the ABC transporter FtsEX involved in
VY92_010370	COG0762	integral membrane protein
VY92_010375	COG0598	Magnesium transport protein CorA
VY92_010385	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
VY92_010410	COG3621	Patatin-like phospholipase
VY92_010430	COG4453	Protein conserved in bacteria
VY92_010685	COG0640	Transcriptional regulator
VY92_010700	COG0786	glutamate:sodium symporter activity
VY92_010715	COG3039	Transposase
VY92_010730	COG3039	Transposase
VY92_010775	COG0305	Participates in initiation and elongation during chromosome replication
VY92_010800	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
VY92_010805	COG1194	a g-specific adenine glycosylase
VY92_010810	COG4213	ABC transporter substrate-binding protein
VY92_010815	COG1129	ABC transporter
VY92_010820	COG4214	carbohydrate transport
VY92_010835	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VY92_010850	COG3732	PTS system glucitol sorbitol-specific
VY92_010860	COG1028	Short-chain dehydrogenase reductase Sdr
VY92_010865	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
VY92_010870	COG1349	DNA-binding transcription factor activity
VY92_010885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VY92_010890	COG1757	Na H antiporter
VY92_010895	COG0436	Aminotransferase
VY92_010900	COG2115	Belongs to the xylose isomerase family
VY92_010905	COG1070	Carbohydrate kinase
VY92_010910	COG2207	Transcriptional regulator
VY92_010910	COG1609	Transcriptional regulator
VY92_010950	COG3070	regulator of competence-specific genes
VY92_010970	COG0551	DNA topoisomerase type I activity
VY92_010985	COG0733	neurotransmitter:sodium symporter activity
VY92_010995	COG1858	cytochrome C peroxidase
VY92_011000	COG1132	(ABC) transporter
VY92_011005	COG4988	ABC transporter
VY92_011015	COG0187	DNA topoisomerase II activity
VY92_011020	COG1494	fructose-1,6-bisphosphatase
VY92_011030	COG0716	FMN binding
VY92_011040	COG0357	Ribosomal RNA small subunit methyltransferase G
VY92_011065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VY92_011075	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VY92_011080	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VY92_011090	COG0483	inositol monophosphate 1-phosphatase activity
VY92_011095	COG2271	Major facilitator Superfamily
VY92_011130	COG1230	cation diffusion facilitator family transporter
VY92_011145	COG3153	acetyltransferase
VY92_011165	COG2195	Cleaves the N-terminal amino acid of tripeptides
VY92_011200	COG0019	diaminopimelate decarboxylase activity
VY92_011235	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VY92_011245	COG3119	arylsulfatase activity
VY92_011255	COG0583	DNA-binding transcription factor activity
VY92_011265	COG3956	TIGRFAM MazG family protein
VY92_011280	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VY92_011290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
VY92_011295	COG1114	Component of the transport system for branched-chain amino acids
VY92_011300	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VY92_011305	COG2095	MarC family integral membrane protein
VY92_011320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VY92_011380	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VY92_011400	COG0201	protein transport
VY92_011410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VY92_011415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VY92_011420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VY92_011425	COG0202	RNA polymerase activity
VY92_011430	COG0203	ribosomal protein L17
VY92_011440	COG2960	long-chain fatty acid transporting porin activity
VY92_011445	COG3172	ATPase kinase involved in NAD metabolism
VY92_011450	COG2129	metallophosphoesterase
VY92_011460	COG0582	viral genome integration into host DNA
VY92_011535	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VY92_011550	COG0732	type I restriction modification DNA specificity domain
VY92_011555	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
VY92_011560	COG3056	Lipoprotein
VY92_011580	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VY92_011585	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VY92_011590	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
VY92_011600	COG1477	protein flavinylation
VY92_011605	COG2991	Protein conserved in bacteria
VY92_011615	COG1519	Transferase
VY92_011625	COG0786	glutamate:sodium symporter activity
VY92_011655	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VY92_011665	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VY92_011670	COG3068	Protein conserved in bacteria
VY92_011680	COG1349	DNA-binding transcription factor activity
VY92_011685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VY92_011695	COG0259	pyridoxamine-phosphate oxidase activity
VY92_011700	COG2814	Major facilitator Superfamily
VY92_011705	COG1763	Mo-molybdopterin cofactor biosynthetic process
VY92_011710	COG3086	response to oxidative stress
VY92_011715	COG3026	antisigma factor binding
VY92_011720	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
VY92_011725	COG1595	DNA-templated transcription, initiation
VY92_011740	COG2226	methyltransferase
VY92_011765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VY92_011770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VY92_011775	COG0493	'glutamate synthase
VY92_011780	COG0067	glutamate synthase
VY92_011780	COG0069	glutamate synthase activity
VY92_011780	COG0070	glutamate synthase
VY92_011790	COG0859	PFAM glycosyl transferase family 9
VY92_011795	COG1132	(ABC) transporter
VY92_011805	COG0549	Belongs to the carbamate kinase family
VY92_011815	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
VY92_011825	COG1304	FMN binding
VY92_011830	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VY92_011840	COG0583	DNA-binding transcription factor activity
VY92_011850	COG1304	FMN binding
VY92_011855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VY92_011860	COG0666	response to abiotic stimulus
VY92_011885	COG0675	Transposase, IS605 OrfB family
VY92_011895	COG1126	abc transporter atp-binding protein
VY92_011900	COG0765	amino acid transport
VY92_011905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VY92_011910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VY92_011920	COG3078	GTPase activator activity
VY92_011925	COG0564	pseudouridine synthase activity
VY92_011935	COG3201	nicotinamide mononucleotide transporter
VY92_011940	COG0673	inositol 2-dehydrogenase activity
VY92_011945	COG3676	manually curated
VY92_011955	COG3718	enzyme involved in inositol metabolism
VY92_011970	COG0456	acetyltransferase
VY92_012005	COG0738	Major facilitator superfamily
VY92_012010	COG0235	Class ii aldolase
VY92_012020	COG1070	Carbohydrate kinase
VY92_012025	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
VY92_012030	COG1349	DNA-binding transcription factor activity
VY92_012040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VY92_012055	COG0859	PFAM glycosyl transferase family 9
VY92_012095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VY92_012110	COG3691	Protein conserved in bacteria
VY92_012115	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VY92_012120	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
VY92_012125	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
VY92_012130	COG0363	glucosamine-6-phosphate deaminase activity
VY92_012135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VY92_012140	COG1218	3'(2'),5'-bisphosphate nucleotidase
VY92_012145	COG1297	OPT oligopeptide transporter protein
VY92_012150	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VY92_012155	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VY92_012160	COG1609	Transcriptional regulator
VY92_012165	COG1917	Cupin 2, conserved barrel domain protein
VY92_012175	COG1070	Carbohydrate kinase
VY92_012180	COG1129	ABC transporter
VY92_012185	COG1172	Belongs to the binding-protein-dependent transport system permease family
VY92_012190	COG1879	ABC-type sugar transport system periplasmic component
VY92_012205	COG0051	transcription antitermination factor activity, RNA binding
VY92_012215	COG0088	Forms part of the polypeptide exit tunnel
VY92_012225	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VY92_012230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VY92_012240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VY92_012265	COG0582	viral genome integration into host DNA
VY92_012350	COG3728	DNA packaging