locus-tag	class	description
K5O18_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5O18_00010	COG0592	DNA-directed DNA polymerase activity
K5O18_00020	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K5O18_00025	COG1381	Involved in DNA repair and RecF pathway recombination
K5O18_00030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5O18_00035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5O18_00040	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K5O18_00045	COG0252	asparaginase activity
K5O18_00055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K5O18_00075	COG3133	Outer membrane lipoprotein
K5O18_00080	COG3962	Belongs to the TPP enzyme family
K5O18_00090	COG0673	inositol 2-dehydrogenase activity
K5O18_00100	COG0431	NADPH-dependent FMN reductase
K5O18_00110	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K5O18_00120	COG3307	-O-antigen
K5O18_00125	COG2976	Protein conserved in bacteria
K5O18_00135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K5O18_00140	COG1426	Protein conserved in bacteria
K5O18_00145	COG0471	metal ion transport
K5O18_00145	COG0490	domain, Protein
K5O18_00150	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5O18_00160	COG4589	Belongs to the CDS family
K5O18_00165	COG0521	Mo-molybdopterin cofactor biosynthetic process
K5O18_00175	COG0628	permease
K5O18_00185	COG3063	Type IV pilus biogenesis stability protein PilW
K5O18_00190	COG0758	DNA mediated transformation
K5O18_00195	COG0742	ribosomal rna small subunit methyltransferase
K5O18_00200	COG0552	protein localization to endoplasmic reticulum
K5O18_00205	COG0584	glycerophosphoryl diester phosphodiesterase
K5O18_00210	COG2271	Major facilitator Superfamily
K5O18_00215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K5O18_00225	COG0247	lactate metabolic process
K5O18_00230	COG1349	DNA-binding transcription factor activity
K5O18_00235	COG0705	Rhomboid family
K5O18_00245	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K5O18_00255	COG0546	phosphoglycolate phosphatase activity
K5O18_00260	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K5O18_00270	COG0251	oxidation-reduction process
K5O18_00285	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5O18_00295	COG0512	Glutamine amidotransferase of anthranilate synthase
K5O18_00300	COG0783	Belongs to the Dps family
K5O18_00315	COG0196	riboflavin kinase activity
K5O18_00345	COG0642	Histidine kinase
K5O18_00360	COG0165	Argininosuccinate lyase
K5O18_00365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K5O18_00405	COG0752	glycyl-tRNA synthetase alpha subunit
K5O18_00410	COG4545	Glutaredoxin-related protein
K5O18_00420	COG4804	nuclease activity
K5O18_00425	COG2852	Protein conserved in bacteria
K5O18_00450	COG3676	manually curated
K5O18_00455	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
K5O18_00460	COG4972	Pilus assembly protein
K5O18_00480	COG4796	Type ii and iii secretion system protein
K5O18_00490	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K5O18_00495	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K5O18_00500	COG4701	Protein of unknown function (DUF721)
K5O18_00510	COG0653	protein targeting
K5O18_00515	COG0494	nUDIX hydrolase
K5O18_00520	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K5O18_00545	COG0582	viral genome integration into host DNA
K5O18_00555	COG2026	Addiction module toxin, RelE StbE family
K5O18_00570	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K5O18_00585	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K5O18_00590	COG1328	CTP reductase activity
K5O18_00590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5O18_00595	COG0602	queuosine metabolic process
K5O18_00600	COG3676	manually curated
K5O18_00605	COG0084	hydrolase, TatD family'
K5O18_00615	COG0805	protein transport
K5O18_00620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K5O18_00630	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
K5O18_00640	COG2226	methyltransferase
K5O18_00650	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K5O18_00655	COG1575	Belongs to the MenA family. Type 1 subfamily
K5O18_00665	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K5O18_00670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K5O18_00675	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K5O18_00680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K5O18_00700	COG0006	proline dipeptidase activity
K5O18_00705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5O18_00710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5O18_00715	COG1879	ABC-type sugar transport system periplasmic component
K5O18_00725	COG1129	ABC transporter
K5O18_00730	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5O18_00755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K5O18_00775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K5O18_00785	COG1737	Transcriptional regulator
K5O18_00790	COG2731	YhcH YjgK YiaL family protein
K5O18_00800	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
K5O18_00810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K5O18_00830	COG4771	TonB-dependent receptor
K5O18_00835	COG3721	Heme iron utilization protein
K5O18_00840	COG0748	coenzyme F420 binding
K5O18_00845	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K5O18_00850	COG1792	Involved in formation and maintenance of cell shape
K5O18_00855	COG1077	Cell shape determining protein MreB Mrl
K5O18_00910	COG3676	manually curated
K5O18_00950	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K5O18_00960	COG1028	Short-chain dehydrogenase reductase Sdr
K5O18_00965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K5O18_00970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K5O18_00985	COG1399	metal-binding, possibly nucleic acid-binding protein
K5O18_00990	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K5O18_00995	COG0500	methyltransferase
K5O18_01000	COG2830	Protein of unknown function (DUF452)
K5O18_01010	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K5O18_01020	COG0545	Peptidyl-prolyl cis-trans isomerase
K5O18_01025	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K5O18_01030	COG0194	GDP metabolic process
K5O18_01040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5O18_01045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K5O18_01080	COG3842	ATPase activity
K5O18_01110	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K5O18_01115	COG0513	Belongs to the DEAD box helicase family
K5O18_01120	COG0799	negative regulation of ribosome biogenesis
K5O18_01130	COG0768	penicillin binding
K5O18_01135	COG0772	Belongs to the SEDS family
K5O18_01145	COG1686	Belongs to the peptidase S11 family
K5O18_01165	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K5O18_01170	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
K5O18_01175	COG0437	4 iron, 4 sulfur cluster binding
K5O18_01180	COG3301	Polysulphide reductase, NrfD
K5O18_01190	COG2081	HI0933 family
K5O18_01195	COG4235	cytochrome complex assembly
K5O18_01195	COG3088	subunit of a heme lyase
K5O18_01200	COG4235	cytochrome complex assembly
K5O18_01200	COG3088	subunit of a heme lyase
K5O18_01210	COG1138	Cytochrome C-type biogenesis protein
K5O18_01215	COG1760	l-serine dehydratase
K5O18_01225	COG0121	glutamine amidotransferase
K5O18_01235	COG0204	Acyl-transferase
K5O18_01245	COG1702	phosphate starvation-inducible protein PhoH
K5O18_01255	COG1444	tRNA N-acetyltransferase activity
K5O18_01275	COG3116	cell division
K5O18_01280	COG0768	penicillin binding
K5O18_01290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K5O18_01300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K5O18_01325	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K5O18_01330	COG0849	cell division
K5O18_01335	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K5O18_01340	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K5O18_01355	COG4221	oxidoreductase activity
K5O18_01360	COG3321	synthase
K5O18_01360	COG1028	Short-chain dehydrogenase reductase Sdr
K5O18_01360	COG0604	alcohol dehydrogenase
K5O18_01365	COG1605	Chorismate mutase
K5O18_01365	COG0077	Prephenate dehydratase
K5O18_01370	COG4974	Belongs to the 'phage' integrase family
K5O18_01375	COG2814	Major facilitator Superfamily
K5O18_01380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K5O18_01390	COG3266	domain, Protein
K5O18_01390	COG3061	Opacity-associated protein A
K5O18_01395	COG1509	lysine 2,3-aminomutase activity
K5O18_01405	COG2026	Addiction module toxin, RelE StbE family
K5O18_01435	COG1177	transmembrane transport
K5O18_01445	COG3842	ATPase activity
K5O18_01450	COG0584	glycerophosphoryl diester phosphodiesterase
K5O18_01455	COG1487	ribonuclease activity
K5O18_01465	COG0800	Aldolase
K5O18_01470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5O18_01490	COG3119	arylsulfatase activity
K5O18_01500	COG2222	sugar isomerase
K5O18_01505	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5O18_01510	COG3715	PTS system
K5O18_01515	COG3716	PTS system mannose fructose sorbose family IID component
K5O18_01520	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5O18_01520	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5O18_01535	COG0641	radical SAM
K5O18_01540	COG3119	arylsulfatase activity
K5O18_01550	COG1349	DNA-binding transcription factor activity
K5O18_01555	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K5O18_01560	COG3684	Belongs to the aldolase LacD family
K5O18_01575	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K5O18_01580	COG2391	methyltransferase activity
K5O18_01585	COG2897	thiosulfate sulfurtransferase activity
K5O18_01590	COG0527	aspartate kinase activity
K5O18_01600	COG2860	membrane
K5O18_01610	COG2067	long-chain fatty acid transport protein
K5O18_01615	COG3549	Plasmid maintenance system killer
K5O18_01620	COG3093	addiction module antidote protein HigA
K5O18_01625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K5O18_01635	COG0861	Integral membrane protein TerC family
K5O18_01680	COG0436	Aminotransferase
K5O18_01695	COG2267	carboxylic ester hydrolase activity
K5O18_01750	COG1028	Short-chain dehydrogenase reductase Sdr
K5O18_01765	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K5O18_01780	COG2186	Transcriptional regulator
K5O18_01795	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5O18_01800	COG1137	ATPase activity
K5O18_01805	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
K5O18_01810	COG3117	lipopolysaccharide transmembrane transporter activity
K5O18_01820	COG1127	ABC transporter
K5O18_01825	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K5O18_01830	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K5O18_01835	COG2854	intermembrane phospholipid transfer
K5O18_01840	COG3113	response to antibiotic
K5O18_01845	COG5007	Belongs to the BolA IbaG family
K5O18_01860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K5O18_01865	COG1278	Cold shock
K5O18_01875	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K5O18_01880	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K5O18_01885	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
K5O18_01895	COG2932	Transcriptional regulator
K5O18_01900	COG3423	Transcriptional regulator
K5O18_01905	COG2801	Transposase and inactivated derivatives
K5O18_01930	COG4396	Host-nuclease inhibitor protein Gam
K5O18_01985	COG3676	manually curated
K5O18_01995	COG3023	N-Acetylmuramoyl-L-alanine amidase
K5O18_02035	COG2369	cell adhesion
K5O18_02045	COG5005	Phage virion morphogenesis
K5O18_02050	COG4388	Caudovirus prohead serine protease
K5O18_02055	COG4397	Mu-like prophage major head subunit gpT
K5O18_02065	COG4387	Mu-like prophage protein GP36
K5O18_02080	COG4386	tail sheath protein
K5O18_02215	COG3392	D12 class N6 adenine-specific DNA methyltransferase
K5O18_02230	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
K5O18_02240	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K5O18_02245	COG1053	succinate dehydrogenase
K5O18_02250	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
K5O18_02255	COG0339	signal peptide processing
K5O18_02260	COG2832	Protein of unknown function (DUF454)
K5O18_02265	COG4166	transmembrane transport
K5O18_02270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K5O18_02280	COG0316	Belongs to the HesB IscA family
K5O18_02285	COG0024	Methionine aminopeptidase
K5O18_02295	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K5O18_02345	COG0500	methyltransferase
K5O18_02350	COG1530	ribonuclease E activity
K5O18_02375	COG2965	DNA replication, synthesis of RNA primer
K5O18_02380	COG0360	Binds together with S18 to 16S ribosomal RNA
K5O18_02385	COG0497	DNA recombination
K5O18_02390	COG3676	manually curated
K5O18_02405	COG1940	carbohydrate kinase activity
K5O18_02405	COG1846	Transcriptional regulator
K5O18_02435	COG0330	HflC and HflK could
K5O18_02445	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5O18_02450	COG3381	protein complex oligomerization
K5O18_02455	COG0372	Belongs to the citrate synthase family
K5O18_02460	COG0567	Dehydrogenase, E1 component
K5O18_02475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K5O18_02495	COG0469	pyruvate kinase activity
K5O18_02550	COG2964	Protein conserved in bacteria
K5O18_02555	COG0814	amino acid
K5O18_02570	COG4774	siderophore transport
K5O18_02575	COG5266	PFAM Nickel transport complex, NikM subunit, transmembrane
K5O18_02585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K5O18_02590	COG1120	ATPase activity
K5O18_02595	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
K5O18_02600	COG2824	Alkylphosphonate utilization operon protein PhnA
K5O18_02610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K5O18_02615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K5O18_02620	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K5O18_02630	COG3177	Filamentation induced by cAMP protein fic
K5O18_02645	COG0676	glucose-6-phosphate 1-epimerase activity
K5O18_02650	COG1136	(ABC) transporter
K5O18_02660	COG0577	efflux transmembrane transporter activity
K5O18_02660	COG1136	(ABC) transporter
K5O18_02670	COG1943	Transposase
K5O18_02680	COG0672	)-iron permease
K5O18_02685	COG0489	protein tyrosine kinase activity
K5O18_02690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5O18_02690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K5O18_02695	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K5O18_02695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K5O18_02700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K5O18_02705	COG1434	Gram-negative-bacterium-type cell wall biogenesis
K5O18_02710	COG5039	Polysaccharide pyruvyl transferase
K5O18_02720	COG3306	glycosyltransferase involved in LPS biosynthesis
K5O18_02730	COG1216	Glycosyl transferase, family 2
K5O18_02735	COG1216	Glycosyl transferase, family 2
K5O18_02740	COG2951	lytic endotransglycosylase activity
K5O18_02745	COG1741	Belongs to the pirin family
K5O18_02760	COG2378	regulation of single-species biofilm formation
K5O18_02785	COG4735	regulation of single-species biofilm formation
K5O18_02805	COG3099	Belongs to the UPF0263 family
K5O18_02815	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K5O18_02820	COG1923	regulation of RNA biosynthetic process
K5O18_02830	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K5O18_02835	COG1388	LysM domain
K5O18_02835	COG0860	N-Acetylmuramoyl-L-alanine amidase
K5O18_02840	COG0802	atpase or kinase
K5O18_02845	COG1621	beta-fructofuranosidase activity
K5O18_02850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5O18_02855	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K5O18_02870	COG2089	acid synthase
K5O18_02880	COG3119	arylsulfatase activity
K5O18_02915	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K5O18_02920	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
K5O18_02925	COG1368	sulfuric ester hydrolase activity
K5O18_02935	COG2755	lipolytic protein G-D-S-L family
K5O18_02935	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K5O18_02940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K5O18_02950	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K5O18_02955	COG0745	RESPONSE REGULATOR receiver
K5O18_02960	COG0642	Histidine kinase
K5O18_02965	COG0583	DNA-binding transcription factor activity
K5O18_02970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K5O18_03105	COG3392	D12 class N6 adenine-specific DNA methyltransferase
K5O18_03170	COG4695	Portal protein
K5O18_03250	COG4974	Belongs to the 'phage' integrase family
K5O18_03265	COG0305	Participates in initiation and elongation during chromosome replication
K5O18_03550	COG4453	Protein conserved in bacteria
K5O18_03565	COG3676	manually curated
K5O18_03575	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K5O18_03595	COG0640	Transcriptional regulator
K5O18_03730	COG2831	hemolysin activation secretion protein
K5O18_03740	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K5O18_03745	COG3210	domain, Protein
K5O18_03770	COG2814	Major facilitator Superfamily
K5O18_03775	COG4221	oxidoreductase activity
K5O18_03790	COG0741	lytic transglycosylase activity
K5O18_03795	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5O18_03800	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K5O18_03805	COG1862	Preprotein translocase
K5O18_03815	COG3945	hemerythrin HHE cation binding domain
K5O18_03830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5O18_03835	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K5O18_03835	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K5O18_03835	COG0506	proline dehydrogenase activity
K5O18_03840	COG2056	Na+-H+ antiporter family
K5O18_03845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K5O18_03850	COG0346	lactoylglutathione lyase activity
K5O18_03860	COG0460	homoserine dehydrogenase
K5O18_03860	COG0527	aspartate kinase activity
K5O18_03865	COG0083	homoserine kinase activity
K5O18_03870	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K5O18_03875	COG1393	Belongs to the ArsC family
K5O18_03880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K5O18_03885	COG1876	peptidase activity
K5O18_03895	COG0494	nUDIX hydrolase
K5O18_03900	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K5O18_03905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K5O18_03930	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K5O18_03945	COG1757	Na H antiporter
K5O18_03950	COG0028	Belongs to the TPP enzyme family
K5O18_03955	COG0440	acetolactate synthase activity
K5O18_03960	COG0039	L-malate dehydrogenase activity
K5O18_03970	COG4224	UPF0291 protein
K5O18_03980	COG0778	Nitroreductase
K5O18_03985	COG0616	signal peptide processing
K5O18_03990	COG0583	DNA-binding transcription factor activity
K5O18_04015	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5O18_04020	COG1328	CTP reductase activity
K5O18_04025	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K5O18_04035	COG0187	DNA topoisomerase II activity
K5O18_04040	COG3008	intermembrane lipid transfer
K5O18_04045	COG2995	paraquat-inducible protein a
K5O18_04050	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
K5O18_04055	COG0793	Belongs to the peptidase S41A family
K5O18_04060	COG2989	Protein conserved in bacteria
K5O18_04065	COG3108	Peptidase M15
K5O18_04070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5O18_04075	COG1560	Kdo2-lipid A biosynthetic process
K5O18_04080	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K5O18_04080	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K5O18_04085	COG3005	denitrification pathway
K5O18_04090	COG0243	molybdopterin cofactor binding
K5O18_04095	COG3100	YcgL domain-containing protein
K5O18_04100	COG0450	alkyl hydroperoxide reductase
K5O18_04105	COG0626	cystathionine gamma-synthase activity
K5O18_04120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K5O18_04125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K5O18_04135	COG0582	viral genome integration into host DNA
K5O18_04190	COG3728	DNA packaging
K5O18_04255	COG4680	protein conserved in bacteria
K5O18_04270	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5O18_04280	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K5O18_04285	COG0583	DNA-binding transcription factor activity
K5O18_04305	COG0210	DNA helicase
K5O18_04310	COG2823	Periplasmic or secreted lipoprotein
K5O18_04315	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K5O18_04320	COG0792	nuclease activity
K5O18_04335	COG0009	L-threonylcarbamoyladenylate synthase
K5O18_04345	COG0583	DNA-binding transcription factor activity
K5O18_04350	COG2171	N-acyltransferase activity
K5O18_04360	COG0589	response to stress
K5O18_04365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5O18_04375	COG1528	Iron-storage protein
K5O18_04380	COG1528	Iron-storage protein
K5O18_04385	COG2431	L-lysine efflux transmembrane transporter activity
K5O18_04390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K5O18_04395	COG0303	'Molybdopterin
K5O18_04405	COG1696	Membrane protein involved in D-alanine export
K5O18_04450	COG0315	cyclic pyranopterin monophosphate synthase activity
K5O18_04455	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K5O18_04460	COG0314	molybdopterin synthase activity
K5O18_04475	COG1289	transmembrane transporter activity
K5O18_04485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K5O18_04505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5O18_04510	COG4591	ABC-type transport system involved in lipoprotein release permease component
K5O18_04515	COG1136	(ABC) transporter
K5O18_04520	COG4591	ABC-type transport system involved in lipoprotein release permease component
K5O18_04525	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K5O18_04535	COG2949	membrane
K5O18_04540	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K5O18_04545	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5O18_04550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5O18_04555	COG1121	(ABC) transporter
K5O18_04565	COG2920	part of a sulfur-relay system
K5O18_04570	COG0670	Belongs to the BI1 family
K5O18_04575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5O18_04580	COG1957	nucleoside hydrolase
K5O18_04585	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K5O18_04590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5O18_04605	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5O18_04610	COG0488	(ABC) transporter
K5O18_04615	COG3683	transport system, periplasmic component
K5O18_04620	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
K5O18_04640	COG3306	glycosyltransferase involved in LPS biosynthesis
K5O18_04660	COG0582	viral genome integration into host DNA
K5O18_04670	COG1476	TRANSCRIPTIONal
K5O18_04700	COG2999	glutathione oxidoreductase activity
K5O18_04735	COG3676	manually curated
K5O18_04750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K5O18_04755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K5O18_04755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K5O18_04760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K5O18_04770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K5O18_04780	COG2062	phosphohistidine phosphatase, SixA
K5O18_04790	COG0814	amino acid
K5O18_04800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5O18_04805	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K5O18_04810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K5O18_04815	COG1280	lysine exporter protein (LysE YggA)
K5O18_04825	COG0633	Ferredoxin
K5O18_04840	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5O18_04845	COG3105	Protein conserved in bacteria
K5O18_04850	COG1944	ATP diphosphatase activity
K5O18_04855	COG2226	methyltransferase
K5O18_04860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K5O18_04885	COG0795	lipopolysaccharide-transporting ATPase activity
K5O18_04890	COG0795	lipopolysaccharide-transporting ATPase activity
K5O18_04895	COG0668	transmembrane transport
K5O18_04920	COG0280	phosphate acetyltransferase
K5O18_04920	COG0857	belongs to the CobB CobQ family
K5O18_04930	COG3092	negative regulation of chromosome organization
K5O18_04935	COG1286	toxin biosynthetic process
K5O18_04945	COG0163	prenyltransferase activity
K5O18_04995	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K5O18_05000	COG0308	aminopeptidase N
K5O18_05005	COG0167	dihydroorotate dehydrogenase activity
K5O18_05010	COG0613	PHP domain protein
K5O18_05015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K5O18_05020	COG0287	Prephenate dehydrogenase
K5O18_05020	COG1605	Chorismate mutase
K5O18_05030	COG2808	Putative FMN-binding domain
K5O18_05035	COG3217	Mosc domain protein beta barrel domain protein
K5O18_05035	COG0633	Ferredoxin
K5O18_05045	COG1534	Rna-binding protein
K5O18_05055	COG0142	geranyltranstransferase activity
K5O18_05065	COG0301	tRNA thio-modification
K5O18_05065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5O18_05070	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K5O18_05075	COG0617	tRNA 3'-terminal CCA addition
K5O18_05080	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K5O18_05090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K5O18_05090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K5O18_05095	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5O18_05110	COG2268	Band 7 protein
K5O18_05115	COG2166	iron-sulfur cluster assembly
K5O18_05125	COG1525	nuclease
K5O18_05130	COG1380	Effector of murein hydrolase LrgA
K5O18_05135	COG1346	cytolysis
K5O18_05145	COG1522	sequence-specific DNA binding
K5O18_05165	COG3549	Plasmid maintenance system killer
K5O18_05170	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K5O18_05175	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K5O18_05195	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
K5O18_05200	COG1162	GTPase activity
K5O18_05205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5O18_05210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K5O18_05215	COG2190	(PTS) system
K5O18_05220	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K5O18_05225	COG0508	dehydrogenase complex catalyzes the overall conversion of
K5O18_05230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5O18_05235	COG1538	Outer membrane efflux protein
K5O18_05240	COG1136	(ABC) transporter
K5O18_05240	COG0577	efflux transmembrane transporter activity
K5O18_05245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5O18_05260	COG1640	4-alpha-glucanotransferase
K5O18_05270	COG1523	belongs to the glycosyl hydrolase 13 family
K5O18_05290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K5O18_05300	COG3101	peptidyl-lysine hydroxylation
K5O18_05305	COG1131	(ABC) transporter
K5O18_05310	COG0842	Transport permease protein
K5O18_05320	COG1611	Belongs to the LOG family
K5O18_05325	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K5O18_05325	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K5O18_05335	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
K5O18_05340	COG3098	single-species biofilm formation
K5O18_05365	COG2969	positive regulation of protein catabolic process
K5O18_05380	COG2925	Exonuclease
K5O18_05385	COG0697	spore germination
K5O18_05410	COG0791	NLP P60 protein
K5O18_05415	COG0776	regulation of translation
K5O18_05430	COG0564	pseudouridine synthase activity
K5O18_05440	COG0406	alpha-ribazole phosphatase activity
K5O18_05445	COG0788	formyltetrahydrofolate deformylase activity
K5O18_05450	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K5O18_05455	COG1846	Transcriptional regulator
K5O18_05455	COG1940	carbohydrate kinase activity
K5O18_05475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K5O18_05480	COG1074	ATP-dependent DNA helicase activity
K5O18_05485	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
K5O18_05490	COG2252	PERMEase
K5O18_05495	COG3676	manually curated
K5O18_05500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K5O18_05505	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K5O18_05515	COG1067	ATP-dependent peptidase activity
K5O18_05535	COG1609	Transcriptional regulator
K5O18_05550	COG1278	Cold shock
K5O18_05555	COG3140	Belongs to the UPF0181 family
K5O18_05560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K5O18_05565	COG0285	dihydrofolate synthase activity
K5O18_05595	COG0517	IMP dehydrogenase activity
K5O18_05595	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K5O18_05600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K5O18_05855	COG4695	Portal protein
K5O18_05860	COG0039	L-malate dehydrogenase activity
K5O18_05865	COG1438	arginine binding
K5O18_05870	COG1090	epimerase
K5O18_05875	COG4657	Part of a membrane complex involved in electron transport
K5O18_05885	COG4656	Part of a membrane complex involved in electron transport
K5O18_05890	COG4658	electron transport chain
K5O18_05905	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K5O18_05910	COG0733	neurotransmitter:sodium symporter activity
K5O18_05915	COG0488	(ABC) transporter
K5O18_05920	COG3265	gluconokinase activity
K5O18_05925	COG2610	gluconate transmembrane transporter activity
K5O18_05930	COG3118	belongs to the thioredoxin family
K5O18_05935	COG0492	ferredoxin-NADP+ reductase activity
K5O18_05960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
K5O18_05965	COG0318	PFAM AMP-dependent synthetase and ligase
K5O18_05970	COG1214	PFAM Peptidase M22, glycoprotease
K5O18_05975	COG1199	ATP-dependent helicase activity
K5O18_05985	COG2863	cytochrome
K5O18_05990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
K5O18_05995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K5O18_06000	COG1408	metallophosphoesterase
K5O18_06005	COG1840	ABC-type Fe3 transport system, periplasmic component
K5O18_06010	COG0616	signal peptide processing
K5O18_06025	COG0708	Exodeoxyribonuclease III
K5O18_06035	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K5O18_06045	COG0826	peptidase U32
K5O18_06050	COG1914	H( )-stimulated, divalent metal cation uptake system
K5O18_06055	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K5O18_06060	COG1984	allophanate hydrolase subunit 2
K5O18_06065	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K5O18_06070	COG3955	Domain of unknown function (DUF1919)
K5O18_06075	COG0617	tRNA 3'-terminal CCA addition
K5O18_06080	COG4991	sh3 domain protein
K5O18_06125	COG1704	LemA family
K5O18_06135	COG0247	lactate metabolic process
K5O18_06135	COG0277	FAD linked oxidase domain protein
K5O18_06150	COG3047	cAMP biosynthetic process
K5O18_06165	COG1607	acyl-coa hydrolase
K5O18_06170	COG2350	Protein conserved in bacteria
K5O18_06190	COG1566	PFAM secretion protein HlyD family protein
K5O18_06200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K5O18_06205	COG0195	Participates in both transcription termination and antitermination
K5O18_06220	COG0515	serine threonine protein kinase
K5O18_06225	COG1115	amino acid carrier protein
K5O18_06250	COG1940	carbohydrate kinase activity
K5O18_06255	COG0671	phosphoesterase, PA-phosphatase related
K5O18_06280	COG0307	riboflavin synthase, alpha
K5O18_06290	COG0673	inositol 2-dehydrogenase activity
K5O18_06305	COG3676	manually curated
K5O18_06335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K5O18_06340	COG0586	Pfam SNARE associated Golgi protein
K5O18_06345	COG0322	excinuclease ABC activity
K5O18_06350	COG1116	anion transmembrane transporter activity
K5O18_06355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K5O18_06360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K5O18_06365	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K5O18_06370	COG2835	tetraacyldisaccharide 4'-kinase activity
K5O18_06375	COG1663	tetraacyldisaccharide 4'-kinase activity
K5O18_06380	COG1132	(ABC) transporter
K5O18_06385	COG0658	competence protein
K5O18_06385	COG2333	competence protein COMEC
K5O18_06395	COG0351	phosphomethylpyrimidine kinase
K5O18_06400	COG0352	thiamine-phosphate diphosphorylase activity
K5O18_06410	COG3266	domain, Protein
K5O18_06410	COG3468	outer membrane autotransporter barrel domain protein
K5O18_06415	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K5O18_06420	COG3025	triphosphatase activity
K5O18_06425	COG1392	Phosphate transport regulator
K5O18_06430	COG0306	phosphate transporter
K5O18_06435	COG0288	reversible hydration of carbon dioxide
K5O18_06440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K5O18_06445	COG1448	Aminotransferase
K5O18_06450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K5O18_06455	COG3835	regulator
K5O18_06460	COG2610	gluconate transmembrane transporter activity
K5O18_06465	COG1929	Belongs to the glycerate kinase type-1 family
K5O18_06490	COG0494	nUDIX hydrolase
K5O18_06500	COG1943	Transposase
K5O18_06510	COG3041	Addiction module toxin RelE StbE family
K5O18_06515	COG3077	Addiction module antitoxin, RelB DinJ family
K5O18_06550	COG2932	Transcriptional regulator
K5O18_06570	COG0305	Participates in initiation and elongation during chromosome replication
K5O18_06595	COG3102	Protein conserved in bacteria
K5O18_06605	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
K5O18_06610	COG4149	molybdate abc transporter
K5O18_06615	COG0725	ABC transporter, periplasmic molybdate-binding protein
K5O18_06620	COG2005	Transcriptional regulator
K5O18_06625	COG0786	glutamate:sodium symporter activity
K5O18_06640	COG0730	response to heat
K5O18_06645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K5O18_06655	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
K5O18_06660	COG1178	ABC-type Fe3 transport system permease component
K5O18_06665	COG4143	(ABC) transporter
K5O18_06670	COG3676	manually curated
K5O18_06675	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K5O18_06685	COG3842	ATPase activity
K5O18_06690	COG1176	ABC-type spermidine putrescine transport system, permease component I
K5O18_06695	COG1177	transmembrane transport
K5O18_06700	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K5O18_06705	COG2910	NAD(P)H-binding
K5O18_06710	COG1733	regulation of RNA biosynthetic process
K5O18_06715	COG0281	malic enzyme
K5O18_06725	COG0673	inositol 2-dehydrogenase activity
K5O18_06735	COG1175	transmembrane transport
K5O18_06745	COG3842	ATPase activity
K5O18_06750	COG2186	Transcriptional regulator
K5O18_06755	COG0673	inositol 2-dehydrogenase activity
K5O18_06760	COG1966	Carbon starvation protein
K5O18_06765	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K5O18_06770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K5O18_06775	COG1560	Kdo2-lipid A biosynthetic process
K5O18_06780	COG0730	response to heat
K5O18_06785	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
K5O18_06795	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K5O18_06795	COG3264	Mechanosensitive ion channel
K5O18_06800	COG0318	PFAM AMP-dependent synthetase and ligase
K5O18_06805	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
K5O18_06810	COG0596	Alpha beta hydrolase
K5O18_06820	COG0716	FMN binding
K5O18_06825	COG0735	belongs to the Fur family
K5O18_06835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K5O18_06840	COG3094	Invasion gene expression up-regulator, SirB
K5O18_06855	COG4221	oxidoreductase activity
K5O18_06870	COG1073	alpha beta
K5O18_06875	COG2814	Major facilitator Superfamily
K5O18_06900	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K5O18_06925	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5O18_06935	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K5O18_06940	COG0525	valine-tRNA ligase activity
K5O18_06945	COG4185	zeta toxin
K5O18_06955	COG2153	protein acetylation
K5O18_06960	COG2927	DNA polymerase III (CHI subunit)
K5O18_06970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K5O18_06975	COG0512	Glutamine amidotransferase of anthranilate synthase
K5O18_06980	COG1942	4-Oxalocrotonate Tautomerase
K5O18_06985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K5O18_06990	COG0134	indole-3-glycerol-phosphate synthase activity
K5O18_06990	COG0135	phosphoribosylanthranilate isomerase activity
K5O18_07000	COG0159	tryptophan synthase activity
K5O18_07030	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K5O18_07030	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K5O18_07035	COG0516	GMP reductase activity
K5O18_07035	COG0517	IMP dehydrogenase activity
K5O18_07050	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K5O18_07050	COG0519	Catalyzes the synthesis of GMP from XMP
K5O18_07055	COG0582	viral genome integration into host DNA
K5O18_07120	COG1598	PFAM Uncharacterised protein family UPF0150
K5O18_07190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K5O18_07215	COG1783	phage Terminase large subunit
K5O18_07220	COG3728	DNA packaging
K5O18_07275	COG3617	BRO family, N-terminal domain
K5O18_07295	COG1484	DNA-dependent DNA replication
K5O18_07375	COG3617	BRO family, N-terminal domain
K5O18_07505	COG3646	Phage regulatory protein
K5O18_07530	COG3179	chitinase
K5O18_07850	COG3617	BRO family, N-terminal domain
K5O18_07920	COG3617	BRO family, N-terminal domain
K5O18_07950	COG0251	oxidation-reduction process
K5O18_07955	COG3021	interspecies interaction between organisms
K5O18_07965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5O18_07995	COG3676	manually curated
K5O18_08020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K5O18_08025	COG0697	spore germination
K5O18_08040	COG0142	geranyltranstransferase activity
K5O18_08045	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K5O18_08055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K5O18_08060	COG0626	cystathionine gamma-synthase activity
K5O18_08205	COG4695	Portal protein
K5O18_08315	COG4974	Belongs to the 'phage' integrase family
K5O18_08320	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K5O18_08325	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K5O18_08330	COG0720	synthase
K5O18_08335	COG0602	queuosine metabolic process
K5O18_08375	COG0463	Glycosyl transferase, family 2
K5O18_08420	COG1793	dna ligase
K5O18_08425	COG0363	glucosamine-6-phosphate deaminase activity
K5O18_08430	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K5O18_08435	COG0590	tRNA wobble adenosine to inosine editing
K5O18_08450	COG0730	response to heat
K5O18_08455	COG0494	nUDIX hydrolase
K5O18_08465	COG3023	N-Acetylmuramoyl-L-alanine amidase
K5O18_08470	COG4969	Belongs to the N-Me-Phe pilin family
K5O18_08475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K5O18_08480	COG0528	UMP kinase activity
K5O18_08490	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K5O18_08500	COG0575	Belongs to the CDS family
K5O18_08505	COG0750	zinc metalloprotease
K5O18_08515	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
K5O18_08520	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K5O18_08525	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K5O18_08540	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K5O18_08550	COG1466	dna polymerase III delta subunit
K5O18_08555	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K5O18_08560	COG0495	leucyl-tRNA aminoacylation
K5O18_08580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5O18_08585	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K5O18_08590	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K5O18_08620	COG0328	RNA-DNA hybrid ribonuclease activity
K5O18_08635	COG3716	PTS system mannose fructose sorbose family IID component
K5O18_08640	COG3715	PTS system
K5O18_08645	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5O18_08645	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5O18_08650	COG1459	type II secretion system
K5O18_08660	COG0237	dephospho-CoA kinase activity
K5O18_08660	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K5O18_08675	COG1115	amino acid carrier protein
K5O18_08680	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K5O18_08685	COG1917	Cupin 2, conserved barrel domain protein
K5O18_08685	COG4977	sequence-specific DNA binding
K5O18_08690	COG5413	integral membrane protein
K5O18_08700	COG4178	(ABC) transporter
K5O18_08710	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K5O18_08725	COG1012	belongs to the aldehyde dehydrogenase family
K5O18_08725	COG1454	alcohol dehydrogenase
K5O18_08730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K5O18_08735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K5O18_08745	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K5O18_08750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K5O18_08755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K5O18_08760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K5O18_08795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5O18_08805	COG2990	Protein conserved in bacteria
K5O18_08810	COG0612	Peptidase, M16
K5O18_08815	COG4771	TonB-dependent receptor
K5O18_08825	COG0539	negative regulation of cytoplasmic translation
K5O18_08830	COG0776	regulation of translation
K5O18_08835	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
K5O18_08840	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K5O18_08850	COG0023	Translation Initiation Factor
K5O18_08870	COG0745	RESPONSE REGULATOR receiver
K5O18_08875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K5O18_08880	COG0151	Belongs to the GarS family
K5O18_08895	COG2259	Doxx family
K5O18_08900	COG3676	manually curated
K5O18_08920	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K5O18_08930	COG4172	Belongs to the ABC transporter superfamily
K5O18_08935	COG4171	peptide transport system, permease
K5O18_08950	COG3106	COG3106 Predicted ATPase
K5O18_08960	COG3283	Transcriptional regulator of aromatic amino acids metabolism
K5O18_08965	COG0531	amino acid
K5O18_08980	COG0012	GTP binding
K5O18_08990	COG2867	negative regulation of translational initiation
K5O18_09000	COG2850	peptidyl-arginine hydroxylation
K5O18_09015	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K5O18_09020	COG0739	heme binding
K5O18_09030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K5O18_09065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K5O18_09070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K5O18_09075	COG1643	Atp-dependent helicase
K5O18_09090	COG1879	ABC-type sugar transport system periplasmic component
K5O18_09095	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5O18_09105	COG1129	ABC transporter
K5O18_09110	COG2390	Transcriptional regulator
K5O18_09120	COG0471	metal ion transport
K5O18_09130	COG0583	DNA-binding transcription factor activity
K5O18_09135	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
K5O18_09140	COG1687	branched-chain amino acid
K5O18_09160	COG2864	formate dehydrogenase
K5O18_09165	COG0437	4 iron, 4 sulfur cluster binding
K5O18_09185	COG2217	Heavy metal translocating P-type atpase
K5O18_09230	COG3676	manually curated
K5O18_09240	COG3210	domain, Protein
K5O18_09250	COG3210	domain, Protein
K5O18_09320	COG3210	domain, Protein
K5O18_09325	COG2831	hemolysin activation secretion protein
K5O18_09335	COG1846	Transcriptional regulator
K5O18_09340	COG1566	PFAM secretion protein HlyD family protein
K5O18_09345	COG2814	Major facilitator Superfamily
K5O18_09355	COG0557	exoribonuclease II activity
K5O18_09385	COG0681	Belongs to the peptidase S26 family
K5O18_09425	COG0105	UTP biosynthetic process
K5O18_09445	COG2198	Histidine kinase
K5O18_09445	COG5002	protein histidine kinase activity
K5O18_09445	COG0784	Response regulator, receiver
K5O18_09450	COG0385	Bile acid
K5O18_09455	COG2814	Major facilitator Superfamily
K5O18_09470	COG2252	PERMEase
K5O18_09475	COG1555	photosystem II stabilization
K5O18_09480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K5O18_09485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5O18_09495	COG1238	metal cluster binding
K5O18_09500	COG0110	maltose O-acetyltransferase activity
K5O18_09505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K5O18_09530	COG1238	metal cluster binding
K5O18_09550	COG4783	chaperone-mediated protein folding
K5O18_09560	COG0814	amino acid
K5O18_09565	COG2226	methyltransferase
K5O18_09570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K5O18_09575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K5O18_09595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K5O18_09595	COG0131	Imidazoleglycerol-phosphate dehydratase
K5O18_09600	COG4804	nuclease activity
K5O18_09610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5O18_09620	COG0107	imidazoleglycerol-phosphate synthase activity
K5O18_09635	COG3161	chorismate lyase activity
K5O18_09640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K5O18_09645	COG2233	PERMEase
K5O18_09650	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K5O18_09655	COG0066	3-isopropylmalate dehydratase activity
K5O18_09675	COG4133	protoheme IX ABC transporter activity
K5O18_09680	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K5O18_09685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K5O18_09690	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K5O18_09700	COG1138	Cytochrome C-type biogenesis protein
K5O18_09705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K5O18_09720	COG4211	Belongs to the binding-protein-dependent transport system permease family
K5O18_09725	COG1129	ABC transporter
K5O18_09730	COG1879	ABC-type sugar transport system periplasmic component
K5O18_09735	COG1085	galactose-1-phosphate uridylyltransferase
K5O18_09745	COG2017	converts alpha-aldose to the beta-anomer
K5O18_09760	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K5O18_09765	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
K5O18_09770	COG1882	Formate acetyltransferase
K5O18_09775	COG2116	formate transmembrane transporter activity
K5O18_09780	COG0537	adenosine 5'-monophosphoramidase activity
K5O18_09795	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5O18_09810	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K5O18_09815	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K5O18_09820	COG0254	rRNA binding
K5O18_09825	COG1253	flavin adenine dinucleotide binding
K5O18_09835	COG0084	hydrolase, TatD family'
K5O18_09840	COG0470	DNA polymerase III
K5O18_09845	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K5O18_09850	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K5O18_09865	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K5O18_09880	COG0330	HflC and HflK could
K5O18_09885	COG0330	HflC and HflK could
K5O18_09900	COG0326	Molecular chaperone. Has ATPase activity
K5O18_09905	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
K5O18_09910	COG3091	SprT-like family
K5O18_09915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K5O18_09920	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K5O18_09930	COG0038	chloride channel
K5O18_09955	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K5O18_09960	COG3676	manually curated
K5O18_09980	COG0210	DNA helicase
K5O18_09985	COG5645	(Lipo)protein
K5O18_10015	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K5O18_10020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K5O18_10025	COG1309	transcriptional regulator
K5O18_10045	COG2183	response to ionizing radiation
K5O18_10050	COG1114	Component of the transport system for branched-chain amino acids
K5O18_10055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5O18_10075	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
K5O18_10080	COG0456	acetyltransferase
K5O18_10085	COG1022	Amp-dependent synthetase and ligase
K5O18_10090	COG1027	Aspartate ammonia-lyase
K5O18_10110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K5O18_10115	COG3263	regulation of cellular component size
K5O18_10120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5O18_10120	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K5O18_10135	COG3722	fumarate hydratase activity
K5O18_10140	COG0246	Mannitol dehydrogenase
K5O18_10155	COG0848	biopolymer transport protein
K5O18_10160	COG0811	peptide transport
K5O18_10165	COG4536	flavin adenine dinucleotide binding
K5O18_10170	COG4137	Cytochrome C assembly protein
K5O18_10175	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K5O18_10185	COG3036	rescue of stalled ribosome
K5O18_10190	COG1393	Belongs to the ArsC family
K5O18_10200	COG1126	abc transporter atp-binding protein
K5O18_10205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5O18_10210	COG4215	(ABC) transporter
K5O18_10215	COG4160	amino acid transport
K5O18_10240	COG0174	glutamine synthetase
K5O18_10245	COG1217	gtp-binding protein TYPA
K5O18_10260	COG3306	glycosyltransferase involved in LPS biosynthesis
K5O18_10275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5O18_10295	COG0312	modulator of DNA gyrase
K5O18_10300	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K5O18_10310	COG1271	oxidase subunit
K5O18_10315	COG1294	oxidase, subunit
K5O18_10325	COG3790	cyd operon protein YbgE
K5O18_10335	COG0824	Thioesterase
K5O18_10340	COG0811	peptide transport
K5O18_10345	COG0848	biopolymer transport protein
K5O18_10350	COG3064	Membrane
K5O18_10375	COG2165	general secretion pathway protein
K5O18_10380	COG4795	General secretion pathway protein
K5O18_10395	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K5O18_10400	COG0561	phosphatase activity
K5O18_10410	COG3623	hexulose-6-phosphate isomerase
K5O18_10435	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
K5O18_10460	COG0471	metal ion transport
K5O18_10465	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
K5O18_10465	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K5O18_10470	COG3051	citrate lyase alpha subunit
K5O18_10475	COG2301	Belongs to the HpcH HpaI aldolase family
K5O18_10485	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
K5O18_10525	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
K5O18_10530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K5O18_10535	COG1739	Uncharacterized protein family UPF0029
K5O18_10540	COG0425	Belongs to the sulfur carrier protein TusA family
K5O18_10550	COG4942	peptidase
K5O18_10555	COG2861	carbohydrate metabolic process
K5O18_10560	COG1040	competence protein
K5O18_10580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K5O18_10590	COG3676	manually curated
K5O18_10600	COG3062	negative regulation of establishment of protein localization
K5O18_10605	COG0243	molybdopterin cofactor binding
K5O18_10610	COG0437	4 iron, 4 sulfur cluster binding
K5O18_10615	COG0348	domain, Protein
K5O18_10620	COG3043	anaerobic respiration
K5O18_10625	COG3005	denitrification pathway
K5O18_10635	COG4785	May be involved in cell division
K5O18_10640	COG0513	Belongs to the DEAD box helicase family
K5O18_10655	COG3676	manually curated
K5O18_10680	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
K5O18_10685	COG0569	domain protein
K5O18_10690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K5O18_10690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K5O18_10705	COG1252	NADH dehydrogenase
K5O18_10710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K5O18_10720	COG0191	fructose-bisphosphate aldolase activity
K5O18_10725	COG0126	phosphoglycerate kinase activity
K5O18_10730	COG3719	Belongs to the RNase T2 family
K5O18_10735	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K5O18_10740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K5O18_10745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K5O18_10755	COG0778	Nitroreductase
K5O18_10760	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
K5O18_10765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K5O18_10780	COG1045	serine acetyltransferase
K5O18_10785	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K5O18_10790	COG2194	sulfuric ester hydrolase activity
K5O18_10795	COG0789	Transcriptional regulator
K5O18_10800	COG2814	Major facilitator Superfamily
K5O18_10810	COG0281	malic enzyme
K5O18_10810	COG0280	phosphate acetyltransferase
K5O18_10820	COG1368	sulfuric ester hydrolase activity
K5O18_10825	COG0335	large ribosomal subunit rRNA binding
K5O18_10835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K5O18_10840	COG0228	four-way junction DNA binding
K5O18_10845	COG0859	PFAM glycosyl transferase family 9
K5O18_10850	COG0463	Glycosyl transferase, family 2
K5O18_10855	COG0561	phosphatase activity
K5O18_10860	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5O18_10860	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5O18_10865	COG3715	PTS system
K5O18_10870	COG3716	PTS system mannose fructose sorbose family IID component
K5O18_10885	COG0633	Ferredoxin
K5O18_10890	COG0443	Heat shock 70 kDa protein
K5O18_10900	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K5O18_10910	COG0822	iron-sulfur transferase activity
K5O18_10920	COG1959	2 iron, 2 sulfur cluster binding
K5O18_10925	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K5O18_10940	COG2837	iron assimilation
K5O18_10950	COG0513	Belongs to the DEAD box helicase family
K5O18_10965	COG2853	Lipoprotein
K5O18_10985	COG0004	ammonium transporteR
K5O18_10990	COG2990	Protein conserved in bacteria
K5O18_10995	COG0433	COG0433 Predicted ATPase
K5O18_11010	COG1496	oxidoreductase activity
K5O18_11030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K5O18_11035	COG0668	transmembrane transport
K5O18_11040	COG0248	Ppx GppA phosphatase
K5O18_11045	COG2911	Protein conserved in bacteria
K5O18_11050	COG0729	surface antigen
K5O18_11055	COG0728	peptidoglycan biosynthetic process
K5O18_11060	COG0268	Binds directly to 16S ribosomal RNA
K5O18_11070	COG0560	Phosphoserine phosphatase
K5O18_11085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K5O18_11090	COG3085	chromosome segregation
K5O18_11095	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K5O18_11100	COG3084	Protein conserved in bacteria
K5O18_11105	COG1940	carbohydrate kinase activity
K5O18_11110	COG1028	Short-chain dehydrogenase reductase Sdr
K5O18_11115	COG1070	Carbohydrate kinase
K5O18_11120	COG1879	ABC-type sugar transport system periplasmic component
K5O18_11125	COG1129	ABC transporter
K5O18_11130	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5O18_11135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K5O18_11135	COG2190	(PTS) system
K5O18_11135	COG1263	PTS System
K5O18_11145	COG0354	folic acid binding
K5O18_11150	COG1561	YicC-like family, N-terminal region
K5O18_11155	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K5O18_11160	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K5O18_11165	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K5O18_11175	COG0402	S-adenosylhomocysteine deaminase activity
K5O18_11180	COG3083	sulfuric ester hydrolase activity
K5O18_11195	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K5O18_11200	COG0745	RESPONSE REGULATOR receiver
K5O18_11205	COG1584	GPR1 FUN34 yaaH family protein
K5O18_11210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K5O18_11215	COG0085	RNA polymerase activity
K5O18_11235	COG0081	regulation of translation
K5O18_11240	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
K5O18_11255	COG1476	TRANSCRIPTIONal
K5O18_11270	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K5O18_11275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5O18_11295	COG2168	tRNA wobble position uridine thiolation
K5O18_11310	COG2964	Protein conserved in bacteria
K5O18_11315	COG0545	Peptidyl-prolyl cis-trans isomerase
K5O18_11320	COG2900	Belongs to the SlyX family
K5O18_11325	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K5O18_11325	COG0678	peroxiredoxin activity
K5O18_11330	COG0583	DNA-binding transcription factor activity
K5O18_11335	COG1309	transcriptional regulator
K5O18_11340	COG2267	carboxylic ester hydrolase activity
K5O18_11345	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K5O18_11350	COG0561	phosphatase activity
K5O18_11360	COG3978	acetolactate synthase activity
K5O18_11385	COG3676	manually curated
K5O18_11395	COG1476	TRANSCRIPTIONal
K5O18_11405	COG1522	sequence-specific DNA binding
K5O18_11415	COG3021	interspecies interaction between organisms
K5O18_11425	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
K5O18_11430	COG2818	Glycosylase
K5O18_11435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K5O18_11440	COG3477	response to acidic pH
K5O18_11455	COG0538	isocitrate dehydrogenase activity
K5O18_11475	COG4145	pantothenate transmembrane transporter activity
K5O18_11480	COG3924	membrane
K5O18_11485	COG0439	Biotin carboxylase
K5O18_11490	COG0511	ligase activity, forming carbon-carbon bonds
K5O18_11510	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K5O18_11520	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K5O18_11530	COG1530	ribonuclease E activity
K5O18_11540	COG3276	selenocysteine insertion sequence binding
K5O18_11545	COG1921	L-seryl-tRNASec selenium transferase activity
K5O18_11550	COG3171	Protein conserved in bacteria
K5O18_11555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K5O18_11560	COG0606	chelatase, subunit chli
K5O18_11565	COG0076	glutamate decarboxylase activity
K5O18_11570	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K5O18_11580	COG3071	HemY protein
K5O18_11585	COG2959	enzyme of heme biosynthesis
K5O18_11595	COG0181	hydroxymethylbilane synthase activity
K5O18_11615	COG1295	ribonuclease BN
K5O18_11625	COG1414	Transcriptional regulator
K5O18_11630	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K5O18_11635	COG2731	YhcH YjgK YiaL family protein
K5O18_11640	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K5O18_11645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K5O18_11650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K5O18_11660	COG3623	hexulose-6-phosphate isomerase
K5O18_11665	COG0235	Class ii aldolase
K5O18_11675	COG2884	Cell division ATP-binding protein ftsE
K5O18_11680	COG2177	Part of the ABC transporter FtsEX involved in
K5O18_11690	COG0762	integral membrane protein
K5O18_11695	COG0598	Magnesium transport protein CorA
K5O18_11720	COG1194	a g-specific adenine glycosylase
K5O18_11725	COG4213	ABC transporter substrate-binding protein
K5O18_11730	COG1129	ABC transporter
K5O18_11735	COG4214	carbohydrate transport
K5O18_11750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K5O18_11765	COG3732	PTS system glucitol sorbitol-specific
K5O18_11775	COG1028	Short-chain dehydrogenase reductase Sdr
K5O18_11780	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
K5O18_11785	COG1349	DNA-binding transcription factor activity
K5O18_11800	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K5O18_11805	COG1757	Na H antiporter
K5O18_11810	COG0436	Aminotransferase
K5O18_11815	COG2115	Belongs to the xylose isomerase family
K5O18_11820	COG1070	Carbohydrate kinase
K5O18_11865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K5O18_11880	COG2095	MarC family integral membrane protein
K5O18_11885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K5O18_11890	COG1114	Component of the transport system for branched-chain amino acids
K5O18_11895	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K5O18_11905	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K5O18_11920	COG3956	TIGRFAM MazG family protein
K5O18_11930	COG0583	DNA-binding transcription factor activity
K5O18_11940	COG3119	arylsulfatase activity
K5O18_11950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K5O18_11955	COG0488	(ABC) transporter
K5O18_11960	COG3630	sodium ion export across plasma membrane
K5O18_11975	COG1349	DNA-binding transcription factor activity
K5O18_11980	COG2084	Dehydrogenase
K5O18_11985	COG3395	kinase activity
K5O18_11990	COG0235	Class ii aldolase
K5O18_11995	COG3622	Belongs to the hyi family
K5O18_12000	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
K5O18_12005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5O18_12010	COG2610	gluconate transmembrane transporter activity
K5O18_12025	COG0019	diaminopimelate decarboxylase activity
K5O18_12080	COG2195	Cleaves the N-terminal amino acid of tripeptides
K5O18_12085	COG3153	acetyltransferase
K5O18_12090	COG2249	NAD(P)H dehydrogenase (quinone) activity
K5O18_12095	COG0656	L-ascorbic acid biosynthetic process
K5O18_12100	COG0583	DNA-binding transcription factor activity
K5O18_12125	COG0583	DNA-binding transcription factor activity
K5O18_12135	COG1230	cation diffusion facilitator family transporter
K5O18_12165	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K5O18_12185	COG2271	Major facilitator Superfamily
K5O18_12190	COG0483	inositol monophosphate 1-phosphatase activity
K5O18_12195	COG3475	LICD family
K5O18_12200	COG4750	Nucleotidyl transferase
K5O18_12205	COG0697	spore germination
K5O18_12220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K5O18_12225	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K5O18_12235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K5O18_12260	COG0357	Ribosomal RNA small subunit methyltransferase G
K5O18_12270	COG0716	FMN binding
K5O18_12280	COG1494	fructose-1,6-bisphosphatase
K5O18_12285	COG0187	DNA topoisomerase II activity
K5O18_12295	COG4988	ABC transporter
K5O18_12300	COG1132	(ABC) transporter
K5O18_12305	COG1858	cytochrome C peroxidase
K5O18_12315	COG0733	neurotransmitter:sodium symporter activity
K5O18_12330	COG0551	DNA topoisomerase type I activity
K5O18_12350	COG3676	manually curated
K5O18_12355	COG3070	regulator of competence-specific genes
K5O18_12415	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K5O18_12435	COG0201	protein transport
K5O18_12445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K5O18_12450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K5O18_12455	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K5O18_12460	COG0202	RNA polymerase activity
K5O18_12465	COG0203	ribosomal protein L17
K5O18_12505	COG4396	Host-nuclease inhibitor protein Gam
K5O18_12575	COG3023	N-Acetylmuramoyl-L-alanine amidase
K5O18_12610	COG4383	Mu-like prophage protein gp29
K5O18_12645	COG4387	Mu-like prophage protein GP36
K5O18_12820	COG2960	long-chain fatty acid transporting porin activity
K5O18_12825	COG3172	ATPase kinase involved in NAD metabolism
K5O18_12830	COG2129	metallophosphoesterase
K5O18_12840	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K5O18_12855	COG0732	type I restriction modification DNA specificity domain
K5O18_12860	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
K5O18_12865	COG3056	Lipoprotein
K5O18_12870	COG0271	Belongs to the BolA IbaG family
K5O18_12885	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K5O18_12890	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K5O18_12895	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
K5O18_12905	COG1477	protein flavinylation
K5O18_12910	COG2991	Protein conserved in bacteria
K5O18_12920	COG1519	Transferase
K5O18_12930	COG0786	glutamate:sodium symporter activity
K5O18_12960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K5O18_12970	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K5O18_12975	COG3068	Protein conserved in bacteria
K5O18_12985	COG1349	DNA-binding transcription factor activity
K5O18_12990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K5O18_13000	COG0259	pyridoxamine-phosphate oxidase activity
K5O18_13005	COG2814	Major facilitator Superfamily
K5O18_13010	COG1763	Mo-molybdopterin cofactor biosynthetic process
K5O18_13015	COG3086	response to oxidative stress
K5O18_13020	COG3026	antisigma factor binding
K5O18_13025	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
K5O18_13030	COG1595	DNA-templated transcription, initiation
K5O18_13045	COG2226	methyltransferase
K5O18_13070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K5O18_13075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K5O18_13080	COG0493	'glutamate synthase
K5O18_13085	COG0070	glutamate synthase
K5O18_13085	COG0069	glutamate synthase activity
K5O18_13085	COG0067	glutamate synthase
K5O18_13095	COG0859	PFAM glycosyl transferase family 9
K5O18_13100	COG1132	(ABC) transporter
K5O18_13110	COG0549	Belongs to the carbamate kinase family
K5O18_13120	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K5O18_13130	COG1304	FMN binding
K5O18_13135	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K5O18_13145	COG0583	DNA-binding transcription factor activity
K5O18_13155	COG1304	FMN binding
K5O18_13160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K5O18_13165	COG0666	response to abiotic stimulus
K5O18_13190	COG1126	abc transporter atp-binding protein
K5O18_13195	COG0765	amino acid transport
K5O18_13200	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K5O18_13205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K5O18_13215	COG3078	GTPase activator activity
K5O18_13220	COG0564	pseudouridine synthase activity
K5O18_13245	COG3718	enzyme involved in inositol metabolism
K5O18_13260	COG0456	acetyltransferase
K5O18_13280	COG3423	Transcriptional regulator
K5O18_13285	COG2801	Transposase and inactivated derivatives
K5O18_13290	COG2842	Transposition protein
K5O18_13310	COG4396	Host-nuclease inhibitor protein Gam
K5O18_13340	COG4382	Mu-like prophage protein Gp16
K5O18_13355	COG3023	N-Acetylmuramoyl-L-alanine amidase
K5O18_13375	COG0640	Transcriptional regulator
K5O18_13385	COG4373	Mu-like prophage FluMu protein gp28
K5O18_13530	COG3392	D12 class N6 adenine-specific DNA methyltransferase
K5O18_13560	COG0738	Major facilitator superfamily
K5O18_13565	COG0235	Class ii aldolase
K5O18_13575	COG1070	Carbohydrate kinase
K5O18_13580	COG2407	Converts the aldose L-fucose into the corresponding ketose L-fuculose
K5O18_13585	COG1349	DNA-binding transcription factor activity
K5O18_13600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K5O18_13605	COG0859	PFAM glycosyl transferase family 9
K5O18_13610	COG0859	PFAM glycosyl transferase family 9
K5O18_13645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K5O18_13660	COG3691	Protein conserved in bacteria
K5O18_13665	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K5O18_13670	COG3759	membrane
K5O18_13675	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
K5O18_13680	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
K5O18_13685	COG0363	glucosamine-6-phosphate deaminase activity
K5O18_13690	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K5O18_13695	COG1218	3'(2'),5'-bisphosphate nucleotidase
K5O18_13700	COG1297	OPT oligopeptide transporter protein
K5O18_13705	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K5O18_13710	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K5O18_13715	COG1609	Transcriptional regulator
K5O18_13720	COG1917	Cupin 2, conserved barrel domain protein
K5O18_13730	COG1070	Carbohydrate kinase
K5O18_13735	COG1129	ABC transporter
K5O18_13740	COG1172	Belongs to the binding-protein-dependent transport system permease family
K5O18_13745	COG1879	ABC-type sugar transport system periplasmic component
K5O18_13760	COG0051	transcription antitermination factor activity, RNA binding
K5O18_13770	COG0088	Forms part of the polypeptide exit tunnel
K5O18_13780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K5O18_13785	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K5O18_13795	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K5O18_13890	COG3728	DNA packaging
K5O18_13955	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K5O18_13960	COG0594	ribonuclease P activity