locus-tag	class	description
CEW87_00030	COG0247	lactate metabolic process
CEW87_00055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW87_00115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW87_00120	COG0625	glutathione transferase activity
CEW87_00125	COG0069	glutamate synthase activity
CEW87_00130	COG1454	alcohol dehydrogenase
CEW87_00150	COG4772	TonB-dependent receptor
CEW87_00165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW87_00175	COG1012	belongs to the aldehyde dehydrogenase family
CEW87_00180	COG0693	protein deglycase activity
CEW87_00200	COG1024	Enoyl-CoA hydratase
CEW87_00210	COG2814	Major facilitator Superfamily
CEW87_00215	COG0410	ABC transporter
CEW87_00245	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW87_00250	COG0183	Belongs to the thiolase family
CEW87_00260	COG1024	Enoyl-CoA hydratase
CEW87_00265	COG1960	acyl-CoA dehydrogenase activity
CEW87_00270	COG1960	acyl-CoA dehydrogenase activity
CEW87_00275	COG0837	glucose binding
CEW87_00280	COG0166	Belongs to the GPI family
CEW87_00295	COG0142	geranyltranstransferase activity
CEW87_00300	COG0584	glycerophosphoryl diester phosphodiesterase
CEW87_00315	COG0667	Aldo Keto reductase
CEW87_00320	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CEW87_00325	COG0513	Belongs to the DEAD box helicase family
CEW87_00335	COG1428	Deoxynucleoside kinase
CEW87_00340	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CEW87_00345	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CEW87_00350	COG0517	IMP dehydrogenase activity
CEW87_00350	COG0516	GMP reductase activity
CEW87_00355	COG0308	aminopeptidase N
CEW87_00385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEW87_00395	COG0589	response to stress
CEW87_00400	COG0538	isocitrate dehydrogenase activity
CEW87_00405	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CEW87_00415	COG2010	Cytochrome c
CEW87_00435	COG4654	Cytochrome c, class I
CEW87_00440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CEW87_00445	COG0640	Transcriptional regulator
CEW87_00455	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW87_00470	COG0756	dUTP diphosphatase activity
CEW87_00475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CEW87_00480	COG2003	Belongs to the UPF0758 family
CEW87_00485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CEW87_00490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CEW87_00495	COG1278	Cold shock
CEW87_00500	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CEW87_00505	COG0542	response to heat
CEW87_00510	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CEW87_00515	COG2224	Isocitrate lyase
CEW87_00525	COG0745	RESPONSE REGULATOR receiver
CEW87_00530	COG2205	protein histidine kinase activity
CEW87_00535	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CEW87_00540	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CEW87_00560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CEW87_00565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CEW87_00570	COG0739	heme binding
CEW87_00575	COG0316	Belongs to the HesB IscA family
CEW87_00580	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CEW87_00585	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CEW87_00595	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CEW87_00605	COG0494	nUDIX hydrolase
CEW87_00610	COG0442	prolyl-tRNA aminoacylation
CEW87_00615	COG0741	lytic transglycosylase activity
CEW87_00630	COG0312	modulator of DNA gyrase
CEW87_00635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW87_00645	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CEW87_00650	COG3025	triphosphatase activity
CEW87_00650	COG5607	PFAM CHAD domain containing protein
CEW87_00670	COG0482	sulfurtransferase activity
CEW87_00700	COG0429	hydrolase of the alpha beta-hydrolase fold
CEW87_00710	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CEW87_00715	COG2096	Adenosyltransferase
CEW87_00720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CEW87_00730	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CEW87_00735	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CEW87_00740	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CEW87_00745	COG0521	Mo-molybdopterin cofactor biosynthetic process
CEW87_00750	COG3028	Belongs to the UPF0307 family
CEW87_00755	COG0312	modulator of DNA gyrase
CEW87_00765	COG2951	lytic endotransglycosylase activity
CEW87_00780	COG1346	cytolysis
CEW87_00790	COG5002	protein histidine kinase activity
CEW87_00795	COG0745	RESPONSE REGULATOR receiver
CEW87_00805	COG4251	negative regulation of phosphorylation
CEW87_00815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW87_00825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CEW87_00830	COG0628	permease
CEW87_00835	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CEW87_00845	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CEW87_00855	COG1175	transmembrane transport
CEW87_00870	COG1349	DNA-binding transcription factor activity
CEW87_00875	COG0617	tRNA 3'-terminal CCA addition
CEW87_00895	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CEW87_00900	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CEW87_00905	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CEW87_00915	COG0247	lactate metabolic process
CEW87_00920	COG0277	FAD linked oxidase domain protein
CEW87_00925	COG0277	FAD linked oxidase domain protein
CEW87_00940	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CEW87_00945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CEW87_00950	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CEW87_00955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CEW87_00985	COG4591	ABC-type transport system involved in lipoprotein release permease component
CEW87_01000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEW87_01010	COG0604	alcohol dehydrogenase
CEW87_01020	COG1704	LemA family
CEW87_01050	COG0741	lytic transglycosylase activity
CEW87_01050	COG0739	heme binding
CEW87_01050	COG1196	nuclear chromosome segregation
CEW87_01070	COG2204	response regulator
CEW87_01075	COG4191	Histidine kinase
CEW87_01080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CEW87_01085	COG2030	dehydratase
CEW87_01120	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CEW87_01160	COG0426	domain, Protein
CEW87_01170	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CEW87_01195	COG4657	Part of a membrane complex involved in electron transport
CEW87_01215	COG4659	FMN binding
CEW87_01225	COG2914	Belongs to the UPF0125 (RnfH) family
CEW87_01255	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CEW87_01265	COG4536	flavin adenine dinucleotide binding
CEW87_01280	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CEW87_01295	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CEW87_01310	COG0733	neurotransmitter:sodium symporter activity
CEW87_01315	COG1522	sequence-specific DNA binding
CEW87_01325	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEW87_01335	COG0134	indole-3-glycerol-phosphate synthase activity
CEW87_01340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CEW87_01360	COG1192	Involved in chromosome partitioning
CEW87_01395	COG0629	single-stranded DNA binding
CEW87_01400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CEW87_01585	COG1569	PIN domain
CEW87_01590	COG3311	Transcriptional regulator
CEW87_01645	COG2003	Belongs to the UPF0758 family
CEW87_01730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW87_01735	COG0842	Transport permease protein
CEW87_01735	COG1129	ABC transporter
CEW87_01740	COG0842	Transport permease protein
CEW87_01750	COG1028	Short-chain dehydrogenase reductase Sdr
CEW87_01770	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CEW87_01775	COG0786	glutamate:sodium symporter activity
CEW87_01780	COG3243	poly(R)-hydroxyalkanoic acid synthase
CEW87_01785	COG0589	response to stress
CEW87_01805	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CEW87_01810	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CEW87_01815	COG0583	DNA-binding transcription factor activity
CEW87_01820	COG1396	sequence-specific DNA binding
CEW87_01830	COG0582	viral genome integration into host DNA
CEW87_01840	COG0546	phosphoglycolate phosphatase activity
CEW87_01850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CEW87_01855	COG5212	phosphodiesterase
CEW87_01870	COG3344	reverse transcriptase
CEW87_01875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CEW87_01880	COG0045	succinate-CoA ligase (ADP-forming) activity
CEW87_01895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CEW87_01905	COG0805	protein transport
CEW87_01910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CEW87_01915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CEW87_01925	COG0140	phosphoribosyl-ATP diphosphatase activity
CEW87_01930	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CEW87_01935	COG0107	imidazoleglycerol-phosphate synthase activity
CEW87_01940	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CEW87_01945	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CEW87_01950	COG0131	Imidazoleglycerol-phosphate dehydratase
CEW87_01955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CEW87_01960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CEW87_01965	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CEW87_01970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CEW87_01975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CEW87_01985	COG0842	Transport permease protein
CEW87_01990	COG1131	(ABC) transporter
CEW87_02010	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CEW87_02015	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CEW87_02020	COG1127	ABC transporter
CEW87_02085	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
CEW87_02090	COG1024	Enoyl-CoA hydratase
CEW87_02105	COG0204	Acyl-transferase
CEW87_02110	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CEW87_02115	COG0751	glycine-tRNA ligase activity
CEW87_02120	COG0752	glycyl-tRNA synthetase alpha subunit
CEW87_02125	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CEW87_02130	COG4535	Mg2 and Co2 transporter CorC
CEW87_02135	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CEW87_02140	COG1702	phosphate starvation-inducible protein PhoH
CEW87_02145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEW87_02160	COG3706	GGDEF domain
CEW87_02165	COG1739	Uncharacterized protein family UPF0029
CEW87_02170	COG1028	Short-chain dehydrogenase reductase Sdr
CEW87_02175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEW87_02180	COG0583	DNA-binding transcription factor activity
CEW87_02190	COG2308	Evidence 4 Homologs of previously reported genes of
CEW87_02215	COG0511	ligase activity, forming carbon-carbon bonds
CEW87_02220	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CEW87_02225	COG1607	acyl-coa hydrolase
CEW87_02230	COG3634	alkyl hydroperoxide reductase activity
CEW87_02245	COG2177	Part of the ABC transporter FtsEX involved in
CEW87_02250	COG2884	Cell division ATP-binding protein ftsE
CEW87_02260	COG0612	Peptidase, M16
CEW87_02265	COG0612	Peptidase, M16
CEW87_02270	COG0742	ribosomal rna small subunit methyltransferase
CEW87_02275	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CEW87_02280	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CEW87_02285	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CEW87_02290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CEW87_02300	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CEW87_02305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CEW87_02315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CEW87_02320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CEW87_02325	COG0193	aminoacyl-tRNA hydrolase activity
CEW87_02330	COG0012	GTP binding
CEW87_02335	COG3002	Belongs to the UPF0753 family
CEW87_02340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CEW87_02350	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CEW87_02355	COG2169	Transcriptional regulator
CEW87_02355	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CEW87_02370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CEW87_02375	COG1053	succinate dehydrogenase
CEW87_02395	COG4263	nitrous-oxide reductase activity
CEW87_02420	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CEW87_02445	COG3245	cytochrome
CEW87_02470	COG0583	DNA-binding transcription factor activity
CEW87_02475	COG0477	Major facilitator Superfamily
CEW87_02525	COG3181	Tripartite tricarboxylate transporter family receptor
CEW87_02530	COG0251	oxidation-reduction process
CEW87_02535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW87_02590	COG3459	Glycosyltransferase 36 associated
CEW87_02605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEW87_02610	COG0798	PFAM Bile acid sodium symporter
CEW87_02625	COG0583	DNA-binding transcription factor activity
CEW87_02630	COG1741	Belongs to the pirin family
CEW87_02650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CEW87_02655	COG3842	ATPase activity
CEW87_02660	COG1177	transmembrane transport
CEW87_02665	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW87_02675	COG1349	DNA-binding transcription factor activity
CEW87_02680	COG2267	carboxylic ester hydrolase activity
CEW87_02685	COG0697	spore germination
CEW87_02690	COG0583	DNA-binding transcription factor activity
CEW87_02700	COG5002	protein histidine kinase activity
CEW87_02700	COG3447	MASE1 domain protein
CEW87_02700	COG5001	Diguanylate cyclase
CEW87_02720	COG0463	Glycosyl transferase, family 2
CEW87_02765	COG0436	Aminotransferase
CEW87_02770	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CEW87_02775	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CEW87_02775	COG0235	Class ii aldolase
CEW87_02785	COG2084	Dehydrogenase
CEW87_02790	COG2084	Dehydrogenase
CEW87_02795	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CEW87_02805	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CEW87_02815	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CEW87_02845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CEW87_02855	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CEW87_02865	COG0784	Response regulator, receiver
CEW87_02870	COG4251	negative regulation of phosphorylation
CEW87_02880	COG0629	single-stranded DNA binding
CEW87_02885	COG2814	Major facilitator Superfamily
CEW87_02900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CEW87_02905	COG0203	ribosomal protein L17
CEW87_02910	COG0202	RNA polymerase activity
CEW87_02915	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CEW87_02920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CEW87_02925	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CEW87_02930	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CEW87_02935	COG0201	protein transport
CEW87_02940	COG0200	Binds to the 23S rRNA
CEW87_02945	COG1841	ribosomal large subunit assembly
CEW87_02950	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CEW87_02955	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CEW87_02960	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CEW87_02965	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CEW87_02970	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CEW87_02975	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CEW87_02980	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CEW87_02985	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CEW87_02990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CEW87_02995	COG0255	Belongs to the universal ribosomal protein uL29 family
CEW87_03000	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CEW87_03005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CEW87_03010	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CEW87_03015	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CEW87_03020	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CEW87_03025	COG0089	rRNA binding
CEW87_03030	COG0088	Forms part of the polypeptide exit tunnel
CEW87_03035	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CEW87_03040	COG0051	transcription antitermination factor activity, RNA binding
CEW87_03045	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEW87_03050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CEW87_03055	COG0049	tRNA binding
CEW87_03060	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CEW87_03065	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CEW87_03070	COG0085	RNA polymerase activity
CEW87_03075	COG0222	ribosome binding
CEW87_03080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CEW87_03085	COG0081	regulation of translation
CEW87_03090	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CEW87_03100	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CEW87_03110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CEW87_03135	COG5265	(ABC) transporter
CEW87_03160	COG0252	asparaginase activity
CEW87_03165	COG0583	DNA-binding transcription factor activity
CEW87_03170	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEW87_03180	COG0175	sulfate reduction
CEW87_03185	COG0175	sulfate reduction
CEW87_03190	COG2895	sulfate adenylyltransferase (ATP) activity
CEW87_03205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CEW87_03215	COG0501	Belongs to the peptidase M48B family
CEW87_03220	COG0513	Belongs to the DEAD box helicase family
CEW87_03225	COG0778	Nitroreductase
CEW87_03240	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CEW87_03250	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CEW87_03285	COG0427	acetyl-CoA hydrolase
CEW87_03335	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CEW87_03340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CEW87_03345	COG1538	Outer membrane efflux protein
CEW87_03350	COG0745	RESPONSE REGULATOR receiver
CEW87_03355	COG2205	protein histidine kinase activity
CEW87_03370	COG2818	Glycosylase
CEW87_03380	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CEW87_03385	COG0443	Heat shock 70 kDa protein
CEW87_03390	COG2070	2-Nitropropane dioxygenase
CEW87_03435	COG4191	Histidine kinase
CEW87_03440	COG1764	response to oxidative stress
CEW87_03450	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CEW87_03480	COG2186	Transcriptional regulator
CEW87_03495	COG0583	DNA-binding transcription factor activity
CEW87_03510	COG0745	RESPONSE REGULATOR receiver
CEW87_03510	COG3706	GGDEF domain
CEW87_03520	COG5002	protein histidine kinase activity
CEW87_03520	COG0784	Response regulator, receiver
CEW87_03520	COG2205	protein histidine kinase activity
CEW87_03555	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CEW87_03565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CEW87_03580	COG0070	glutamate synthase
CEW87_03580	COG0069	glutamate synthase activity
CEW87_03580	COG0067	glutamate synthase
CEW87_03585	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CEW87_03590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CEW87_03595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CEW87_03630	COG1965	Belongs to the frataxin family
CEW87_03660	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CEW87_03665	COG0284	orotidine-5'-phosphate decarboxylase activity
CEW87_03670	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CEW87_03675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CEW87_03685	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CEW87_03715	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CEW87_03730	COG1805	sodium ion transport
CEW87_03740	COG0183	Belongs to the thiolase family
CEW87_03745	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW87_03745	COG1024	Enoyl-CoA hydratase
CEW87_03750	COG2067	long-chain fatty acid transport protein
CEW87_03760	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW87_03760	COG1024	Enoyl-CoA hydratase
CEW87_03770	COG1960	acyl-CoA dehydrogenase activity
CEW87_03795	COG0523	cobalamin synthesis protein
CEW87_03800	COG0277	FAD linked oxidase domain protein
CEW87_03820	COG2197	response regulator
CEW87_03835	COG0784	Response regulator, receiver
CEW87_03835	COG2205	protein histidine kinase activity
CEW87_03835	COG2198	Histidine kinase
CEW87_03870	COG0559	Belongs to the binding-protein-dependent transport system permease family
CEW87_03880	COG1022	Amp-dependent synthetase and ligase
CEW87_03985	COG4373	Mu-like prophage FluMu protein gp28
CEW87_04030	COG3023	N-Acetylmuramoyl-L-alanine amidase
CEW87_04070	COG3267	Type II secretory pathway component ExeA
CEW87_04070	COG3409	Peptidoglycan-binding domain 1 protein
CEW87_04090	COG4396	Host-nuclease inhibitor protein Gam
CEW87_04120	COG1703	isobutyryl-CoA mutase activity
CEW87_04120	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CEW87_04120	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CEW87_04145	COG2321	neutral zinc metallopeptidase
CEW87_04150	COG1509	lysine 2,3-aminomutase activity
CEW87_04160	COG0439	Biotin carboxylase
CEW87_04165	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CEW87_04170	COG1703	isobutyryl-CoA mutase activity
CEW87_04175	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CEW87_04175	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CEW87_04180	COG1802	Transcriptional regulator
CEW87_04185	COG1253	flavin adenine dinucleotide binding
CEW87_04190	COG0114	fumarate hydratase activity
CEW87_04195	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEW87_04200	COG3162	membrane
CEW87_04205	COG1024	Enoyl-CoA hydratase
CEW87_04210	COG1492	cobalamin metabolic process
CEW87_04215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEW87_04220	COG1999	signal sequence binding
CEW87_04225	COG0109	protoheme IX farnesyltransferase activity
CEW87_04260	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CEW87_04265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CEW87_04280	COG4221	oxidoreductase activity
CEW87_04300	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CEW87_04315	COG1469	GTP cyclohydrolase I activity
CEW87_04345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEW87_04350	COG1832	CoA-binding protein
CEW87_04375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEW87_04380	COG3568	Endonuclease Exonuclease Phosphatase
CEW87_04385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CEW87_04395	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CEW87_04410	COG3852	Histidine kinase
CEW87_04425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CEW87_04435	COG0237	dephospho-CoA kinase activity
CEW87_04440	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CEW87_04445	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CEW87_04450	COG0494	nUDIX hydrolase
CEW87_04460	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CEW87_04465	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CEW87_04470	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEW87_04500	COG0305	Participates in initiation and elongation during chromosome replication
CEW87_04505	COG0359	binds to the 23S rRNA
CEW87_04510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CEW87_04515	COG2965	DNA replication, synthesis of RNA primer
CEW87_04520	COG0360	Binds together with S18 to 16S ribosomal RNA
CEW87_04530	COG1643	Atp-dependent helicase
CEW87_04550	COG1968	undecaprenyl-diphosphatase activity
CEW87_04555	COG3150	esterase
CEW87_04560	COG2226	methyltransferase
CEW87_04565	COG2962	Rard protein
CEW87_04570	COG0557	exoribonuclease II activity
CEW87_04580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CEW87_04585	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CEW87_04590	COG2239	Acts as a magnesium transporter
CEW87_04595	COG2119	membrane
CEW87_04600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CEW87_04605	COG0352	thiamine-phosphate diphosphorylase activity
CEW87_04615	COG1773	rubredoxin
CEW87_04635	COG0840	transmembrane signaling receptor activity
CEW87_04640	COG0643	Histidine kinase
CEW87_04640	COG2198	Histidine kinase
CEW87_04645	COG0415	Belongs to the DNA photolyase family
CEW87_04650	COG1678	Uncharacterized ACR, COG1678
CEW87_04655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CEW87_04660	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CEW87_04665	COG0540	Belongs to the ATCase OTCase family
CEW87_04675	COG1872	DUF167
CEW87_04680	COG0762	integral membrane protein
CEW87_04725	COG0437	4 iron, 4 sulfur cluster binding
CEW87_04730	COG3383	formate dehydrogenase (NAD+) activity
CEW87_04770	COG0746	molybdenum cofactor guanylyltransferase activity
CEW87_04780	COG1763	Mo-molybdopterin cofactor biosynthetic process
CEW87_04785	COG4191	Histidine kinase
CEW87_04810	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CEW87_04815	COG5002	protein histidine kinase activity
CEW87_04825	COG4654	Cytochrome c, class I
CEW87_04840	COG3842	ATPase activity
CEW87_04855	COG4303	Ethanolamine ammonia lyase large subunit
CEW87_04860	COG4302	ethanolamine ammonia-lyase activity
CEW87_04870	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CEW87_04875	COG0830	nickel cation binding
CEW87_04880	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CEW87_04885	COG0804	urea catabolic process
CEW87_04890	COG0832	Belongs to the urease beta subunit family
CEW87_04900	COG0831	urea catabolic process
CEW87_04905	COG0829	nickel cation binding
CEW87_04910	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CEW87_04910	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CEW87_04915	COG0659	secondary active sulfate transmembrane transporter activity
CEW87_04965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW87_04970	COG1116	anion transmembrane transporter activity
CEW87_04975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW87_05010	COG0559	Belongs to the binding-protein-dependent transport system permease family
CEW87_05030	COG3047	cAMP biosynthetic process
CEW87_05035	COG0513	Belongs to the DEAD box helicase family
CEW87_05045	COG1451	nucleotide metabolic process
CEW87_05050	COG1132	(ABC) transporter
CEW87_05055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEW87_05065	COG0784	Response regulator, receiver
CEW87_05065	COG2198	Histidine kinase
CEW87_05065	COG5002	protein histidine kinase activity
CEW87_05070	COG1538	Outer membrane efflux protein
CEW87_05080	COG2199	diguanylate cyclase activity
CEW87_05080	COG2200	EAL domain
CEW87_05080	COG2203	Gaf domain
CEW87_05095	COG2197	response regulator
CEW87_05100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW87_05105	COG2274	protein secretion by the type I secretion system
CEW87_05125	COG1136	(ABC) transporter
CEW87_05135	COG0735	belongs to the Fur family
CEW87_05140	COG1121	(ABC) transporter
CEW87_05150	COG0803	Belongs to the bacterial solute-binding protein 9 family
CEW87_05155	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CEW87_05160	COG1074	ATP-dependent DNA helicase activity
CEW87_05165	COG0688	phosphatidylethanolamine metabolic process
CEW87_05170	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CEW87_05175	COG3530	Putative quorum-sensing-regulated virulence factor
CEW87_05180	COG2095	MarC family integral membrane protein
CEW87_05190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CEW87_05200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CEW87_05205	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CEW87_05210	COG1538	Outer membrane efflux protein
CEW87_05215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CEW87_05220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW87_05230	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CEW87_05250	COG0419	ATPase involved in DNA repair
CEW87_05255	COG0420	3'-5' exonuclease activity
CEW87_05270	COG1028	Short-chain dehydrogenase reductase Sdr
CEW87_05280	COG0432	Pfam Uncharacterised protein family UPF0047
CEW87_05295	COG0616	signal peptide processing
CEW87_05300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CEW87_05305	COG2022	thiamine diphosphate biosynthetic process
CEW87_05315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CEW87_05325	COG1126	abc transporter atp-binding protein
CEW87_05330	COG0765	amino acid transport
CEW87_05335	COG4597	amino acid ABC transporter
CEW87_05340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW87_05355	COG2814	Major facilitator Superfamily
CEW87_05375	COG0288	reversible hydration of carbon dioxide
CEW87_05380	COG1940	carbohydrate kinase activity
CEW87_05385	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CEW87_05390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CEW87_05400	COG0569	domain protein
CEW87_05405	COG2204	response regulator
CEW87_05410	COG5000	phosphorelay sensor kinase activity
CEW87_05430	COG4106	trans-aconitate 2-methyltransferase activity
CEW87_05440	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CEW87_05445	COG0706	membrane insertase activity
CEW87_05450	COG0594	ribonuclease P activity
CEW87_05455	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CEW87_05460	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CEW87_05510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CEW87_05560	COG2131	deaminase
CEW87_05590	COG0583	DNA-binding transcription factor activity
CEW87_05600	COG0527	aspartate kinase activity
CEW87_05610	COG1131	(ABC) transporter
CEW87_05615	COG0842	Transport permease protein
CEW87_05630	COG0583	DNA-binding transcription factor activity
CEW87_05660	COG3040	lipid binding
CEW87_05695	COG3842	ATPase activity
CEW87_05705	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW87_05710	COG1177	transmembrane transport
CEW87_05725	COG0861	Integral membrane protein TerC family
CEW87_05730	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CEW87_05735	COG1984	allophanate hydrolase subunit 2
CEW87_05740	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CEW87_05765	COG0783	Belongs to the Dps family
CEW87_05775	COG4206	TonB-dependent receptor
CEW87_05780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEW87_05785	COG3706	GGDEF domain
CEW87_05795	COG3909	cytochrome
CEW87_05805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CEW87_05815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CEW87_05825	COG1187	pseudouridine synthase activity
CEW87_05835	COG2974	May be involved in recombination
CEW87_05840	COG1454	alcohol dehydrogenase
CEW87_05855	COG1454	alcohol dehydrogenase
CEW87_05860	COG0410	ABC transporter
CEW87_05865	COG1137	ATPase activity
CEW87_05875	COG0559	Belongs to the binding-protein-dependent transport system permease family
CEW87_05890	COG2204	response regulator
CEW87_05895	COG3852	Histidine kinase
CEW87_05905	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CEW87_05915	COG2922	Belongs to the Smg family
CEW87_05920	COG0758	DNA mediated transformation
CEW87_05930	COG0242	peptide deformylase activity
CEW87_05935	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEW87_05940	COG0501	Belongs to the peptidase M48B family
CEW87_05945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEW87_05950	COG1305	Transglutaminase-like
CEW87_05960	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CEW87_05965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW87_05990	COG0653	protein targeting
CEW87_06010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CEW87_06020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEW87_06030	COG0583	DNA-binding transcription factor activity
CEW87_06035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CEW87_06045	COG0583	DNA-binding transcription factor activity
CEW87_06065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CEW87_06085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEW87_06090	COG0431	NADPH-dependent FMN reductase
CEW87_06095	COG1393	Belongs to the ArsC family
CEW87_06115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CEW87_06145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW87_06150	COG1136	(ABC) transporter
CEW87_06150	COG0577	efflux transmembrane transporter activity
CEW87_06155	COG0577	efflux transmembrane transporter activity
CEW87_06155	COG1136	(ABC) transporter
CEW87_06160	COG0535	radical SAM domain protein
CEW87_06170	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CEW87_06175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CEW87_06195	COG0583	DNA-binding transcription factor activity
CEW87_06200	COG3437	response regulator, receiver
CEW87_06210	COG2205	protein histidine kinase activity
CEW87_06210	COG0784	Response regulator, receiver
CEW87_06210	COG5002	protein histidine kinase activity
CEW87_06235	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW87_06275	COG3608	succinylglutamate desuccinylase aspartoacylase
CEW87_06275	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CEW87_06300	COG3217	Mosc domain protein beta barrel domain protein
CEW87_06300	COG0633	Ferredoxin
CEW87_06305	COG3706	GGDEF domain
CEW87_06330	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CEW87_06370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEW87_06395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW87_06400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW87_06405	COG1116	anion transmembrane transporter activity
CEW87_06405	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW87_06410	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CEW87_06430	COG0697	spore germination
CEW87_06435	COG0683	leucine binding
CEW87_06445	COG3437	response regulator, receiver
CEW87_06450	COG0445	tRNA wobble uridine modification
CEW87_06455	COG0357	Ribosomal RNA small subunit methyltransferase G
CEW87_06460	COG1192	Involved in chromosome partitioning
CEW87_06465	COG1475	DNA binding
CEW87_06490	COG0356	it plays a direct role in the translocation of protons across the membrane
CEW87_06500	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CEW87_06505	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CEW87_06510	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CEW87_06515	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CEW87_06520	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CEW87_06525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CEW87_06540	COG2226	methyltransferase
CEW87_06550	COG0745	RESPONSE REGULATOR receiver
CEW87_06570	COG0121	glutamine amidotransferase
CEW87_06575	COG2391	methyltransferase activity
CEW87_06585	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CEW87_06595	COG0154	amidase activity
CEW87_06600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CEW87_06605	COG1077	Cell shape determining protein MreB Mrl
CEW87_06620	COG0768	penicillin binding
CEW87_06625	COG0772	Belongs to the SEDS family
CEW87_06635	COG1686	Belongs to the peptidase S11 family
CEW87_06645	COG2921	Belongs to the UPF0250 family
CEW87_06650	COG0321	lipoyl(octanoyl) transferase activity
CEW87_06655	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CEW87_06670	COG0210	DNA helicase
CEW87_06680	COG3706	GGDEF domain
CEW87_06685	COG0741	lytic transglycosylase activity
CEW87_06695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEW87_06710	COG1309	transcriptional regulator
CEW87_06715	COG0604	alcohol dehydrogenase
CEW87_06760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CEW87_06765	COG0022	dehydrogenase e1 component
CEW87_06775	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW87_06780	COG0095	Lipoate-protein ligase
CEW87_06805	COG3284	Transcriptional regulator
CEW87_06820	COG4628	conserved protein (DUF2132)
CEW87_06825	COG2066	Belongs to the glutaminase family
CEW87_06855	COG1063	alcohol dehydrogenase
CEW87_06865	COG1397	ADP-ribosylglycohydrolase
CEW87_06980	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEW87_06985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW87_06995	COG0471	metal ion transport
CEW87_07015	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CEW87_07025	COG1053	succinate dehydrogenase
CEW87_07035	COG1012	belongs to the aldehyde dehydrogenase family
CEW87_07060	COG0583	DNA-binding transcription factor activity
CEW87_07090	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CEW87_07095	COG0668	transmembrane transport
CEW87_07170	COG1518	maintenance of DNA repeat elements
CEW87_07175	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CEW87_07195	COG0582	viral genome integration into host DNA
CEW87_07215	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CEW87_07220	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CEW87_07225	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CEW87_07235	COG2815	serine threonine protein kinase
CEW87_07235	COG0515	serine threonine protein kinase
CEW87_07240	COG1561	YicC-like family, N-terminal region
CEW87_07260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW87_07280	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CEW87_07300	COG5002	protein histidine kinase activity
CEW87_07300	COG0784	Response regulator, receiver
CEW87_07300	COG2198	Histidine kinase
CEW87_07310	COG0194	GDP metabolic process
CEW87_07315	COG1758	RNA polymerase activity
CEW87_07320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEW87_07330	COG2226	methyltransferase
CEW87_07335	COG0322	excinuclease ABC activity
CEW87_07345	COG3850	Histidine kinase
CEW87_07350	COG2197	response regulator
CEW87_07365	COG0243	molybdopterin cofactor binding
CEW87_07370	COG0437	4 iron, 4 sulfur cluster binding
CEW87_07375	COG0348	domain, Protein
CEW87_07380	COG3043	anaerobic respiration
CEW87_07385	COG3005	denitrification pathway
CEW87_07390	COG4133	protoheme IX ABC transporter activity
CEW87_07395	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CEW87_07410	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CEW87_07420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEW87_07435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CEW87_07470	COG3706	GGDEF domain
CEW87_07475	COG0475	glutathione-regulated potassium exporter activity
CEW87_07495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CEW87_07500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CEW87_07505	COG0726	polysaccharide deacetylase
CEW87_07510	COG1752	Esterase of the alpha-beta hydrolase superfamily
CEW87_07560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEW87_07570	COG1131	(ABC) transporter
CEW87_07585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CEW87_07630	COG1012	belongs to the aldehyde dehydrogenase family
CEW87_07635	COG1024	Enoyl-CoA hydratase
CEW87_07640	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW87_07645	COG2050	protein possibly involved in aromatic compounds catabolism
CEW87_07655	COG3396	Phenylacetate-CoA oxygenase
CEW87_07660	COG3460	Phenylacetate-CoA oxygenase
CEW87_07665	COG3396	Phenylacetate-CoA oxygenase
CEW87_07670	COG2151	metal-sulfur cluster biosynthetic enzyme
CEW87_07675	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEW87_07685	COG0183	Belongs to the thiolase family
CEW87_07700	COG0411	ABC transporter
CEW87_07715	COG0776	regulation of translation
CEW87_07720	COG0513	Belongs to the DEAD box helicase family
CEW87_07725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEW87_07730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CEW87_07745	COG4232	protein-disulfide reductase activity
CEW87_07780	COG3706	GGDEF domain
CEW87_07785	COG0534	Mate efflux family protein
CEW87_07800	COG2837	iron assimilation
CEW87_07805	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CEW87_07815	COG1028	Short-chain dehydrogenase reductase Sdr
CEW87_07815	COG3321	synthase
CEW87_07815	COG0604	alcohol dehydrogenase
CEW87_07820	COG0583	DNA-binding transcription factor activity
CEW87_07825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CEW87_07830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEW87_07840	COG0210	DNA helicase
CEW87_07860	COG2203	Gaf domain
CEW87_07860	COG3706	GGDEF domain
CEW87_07860	COG5001	Diguanylate cyclase
CEW87_07860	COG4251	negative regulation of phosphorylation
CEW87_07870	COG3706	GGDEF domain
CEW87_07870	COG0745	RESPONSE REGULATOR receiver
CEW87_07910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW87_07915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW87_07930	COG2824	Alkylphosphonate utilization operon protein PhnA
CEW87_07935	COG0366	Alpha amylase catalytic
CEW87_07945	COG4178	(ABC) transporter
CEW87_07955	COG0366	Alpha amylase catalytic
CEW87_07965	COG3706	GGDEF domain
CEW87_07975	COG0210	DNA helicase
CEW87_08000	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CEW87_08005	COG0714	Associated with various cellular activities
CEW87_08010	COG2703	oxygen carrier activity
CEW87_08015	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CEW87_08025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CEW87_08030	COG0235	Class ii aldolase
CEW87_08050	COG3971	2-oxopent-4-enoate hydratase activity
CEW87_08060	COG3384	dioxygenase
CEW87_08065	COG1012	belongs to the aldehyde dehydrogenase family
CEW87_08090	COG1846	Transcriptional regulator
CEW87_08105	COG1024	Enoyl-CoA hydratase
CEW87_08115	COG1024	Enoyl-CoA hydratase
CEW87_08120	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW87_08140	COG0625	glutathione transferase activity
CEW87_08165	COG0583	DNA-binding transcription factor activity
CEW87_08190	COG0642	Histidine kinase
CEW87_08210	COG0347	Belongs to the P(II) protein family
CEW87_08215	COG0004	ammonium transporteR
CEW87_08240	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW87_08240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEW87_08250	COG0174	glutamine synthetase
CEW87_08255	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CEW87_08265	COG0069	glutamate synthase activity
CEW87_08270	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CEW87_08275	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CEW87_08290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEW87_08310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEW87_08320	COG3850	Histidine kinase
CEW87_08325	COG2197	response regulator
CEW87_08340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CEW87_08365	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW87_08370	COG1522	sequence-specific DNA binding
CEW87_08380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW87_08415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CEW87_08420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CEW87_08425	COG0018	arginyl-trna synthetase
CEW87_08435	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CEW87_08440	COG0300	oxidoreductase activity
CEW87_08460	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CEW87_08470	COG3243	poly(R)-hydroxyalkanoic acid synthase
CEW87_08490	COG0288	reversible hydration of carbon dioxide
CEW87_08495	COG0183	Belongs to the thiolase family
CEW87_08500	COG1960	acyl-CoA dehydrogenase activity
CEW87_08510	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW87_08535	COG1309	transcriptional regulator
CEW87_08550	COG0625	glutathione transferase activity
CEW87_08570	COG1960	acyl-CoA dehydrogenase activity
CEW87_08585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CEW87_08590	COG1024	Enoyl-CoA hydratase
CEW87_08600	COG0318	PFAM AMP-dependent synthetase and ligase
CEW87_08625	COG1660	Displays ATPase and GTPase activities
CEW87_08645	COG0412	Dienelactone hydrolase
CEW87_08650	COG1611	Belongs to the LOG family
CEW87_08675	COG0410	ABC transporter
CEW87_08705	COG1522	sequence-specific DNA binding
CEW87_08710	COG0189	ligase activity
CEW87_08725	COG0697	spore germination
CEW87_08745	COG0788	formyltetrahydrofolate deformylase activity
CEW87_08750	COG0004	ammonium transporteR
CEW87_08755	COG0347	Belongs to the P(II) protein family
CEW87_08770	COG0606	chelatase, subunit chli
CEW87_08795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CEW87_08840	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CEW87_08885	COG0606	chelatase, subunit chli
CEW87_08895	COG2814	Major facilitator Superfamily
CEW87_08915	COG0411	ABC transporter
CEW87_08950	COG3501	Rhs element vgr protein
CEW87_09025	COG0604	alcohol dehydrogenase
CEW87_09045	COG1595	DNA-templated transcription, initiation
CEW87_09060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CEW87_09065	COG3284	Transcriptional regulator
CEW87_09070	COG1012	belongs to the aldehyde dehydrogenase family
CEW87_09115	COG2329	Antibiotic biosynthesis monooxygenase
CEW87_09135	COG1683	Conserved Protein
CEW87_09140	COG2076	Multidrug Resistance protein
CEW87_09150	COG0583	DNA-binding transcription factor activity
CEW87_09155	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEW87_09165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CEW87_09170	COG3876	Protein conserved in bacteria
CEW87_09185	COG0668	transmembrane transport
CEW87_09205	COG0180	Tryptophanyl-tRNA synthetase
CEW87_09215	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CEW87_09220	COG0726	polysaccharide deacetylase
CEW87_09260	COG1132	(ABC) transporter
CEW87_09270	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CEW87_09275	COG0859	PFAM glycosyl transferase family 9
CEW87_09280	COG0438	transferase activity, transferring glycosyl groups
CEW87_09285	COG0438	transferase activity, transferring glycosyl groups
CEW87_09290	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CEW87_09305	COG0129	dihydroxy-acid dehydratase activity
CEW87_09340	COG0745	RESPONSE REGULATOR receiver
CEW87_09345	COG2205	protein histidine kinase activity
CEW87_09355	COG1280	lysine exporter protein (LysE YggA)
CEW87_09370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEW87_09375	COG1970	mechanosensitive ion channel activity
CEW87_09380	COG2860	membrane
CEW87_09390	COG0559	Belongs to the binding-protein-dependent transport system permease family
CEW87_09420	COG1194	a g-specific adenine glycosylase
CEW87_09425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW87_09430	COG3706	GGDEF domain
CEW87_09435	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CEW87_09445	COG1132	(ABC) transporter
CEW87_09450	COG0438	transferase activity, transferring glycosyl groups
CEW87_09470	COG1215	transferase activity, transferring glycosyl groups
CEW87_09485	COG1368	sulfuric ester hydrolase activity
CEW87_09505	COG0438	transferase activity, transferring glycosyl groups
CEW87_09510	COG0859	PFAM glycosyl transferase family 9
CEW87_09520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW87_09525	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CEW87_09525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CEW87_09535	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CEW87_09540	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CEW87_09550	COG4206	TonB-dependent receptor
CEW87_09555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CEW87_09560	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CEW87_09570	COG1648	precorrin-2 dehydrogenase activity
CEW87_09570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEW87_09575	COG1797	cobyrinic acid a,c-diamide synthase activity
CEW87_09580	COG1902	pentaerythritol trinitrate reductase activity
CEW87_09600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CEW87_09605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEW87_09610	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CEW87_09615	COG0583	DNA-binding transcription factor activity
CEW87_09630	COG0306	phosphate transporter
CEW87_09650	COG0488	(ABC) transporter
CEW87_09670	COG0004	ammonium transporteR
CEW87_09675	COG2226	methyltransferase
CEW87_09695	COG1652	LysM domain
CEW87_09710	COG5001	Diguanylate cyclase
CEW87_09715	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CEW87_09730	COG1671	Belongs to the UPF0178 family
CEW87_09735	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CEW87_09755	COG1024	Enoyl-CoA hydratase
CEW87_09765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CEW87_09770	COG0602	queuosine metabolic process
CEW87_09785	COG0823	Involved in the tonB-independent uptake of proteins
CEW87_09795	COG0848	biopolymer transport protein
CEW87_09805	COG0824	Thioesterase
CEW87_09815	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CEW87_09820	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CEW87_09830	COG5001	Diguanylate cyclase
CEW87_09830	COG3300	MHYT domain
CEW87_09860	COG3128	pkhd-type hydroxylase
CEW87_09870	COG4774	siderophore transport
CEW87_09880	COG1136	(ABC) transporter
CEW87_09880	COG0577	efflux transmembrane transporter activity
CEW87_09885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW87_09930	COG5001	Diguanylate cyclase
CEW87_09940	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CEW87_09945	COG3132	Protein of unknown function, DUF480
CEW87_09950	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CEW87_09990	COG2264	protein methyltransferase activity
CEW87_09995	COG0439	Biotin carboxylase
CEW87_10000	COG0511	ligase activity, forming carbon-carbon bonds
CEW87_10005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CEW87_10010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEW87_10020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CEW87_10030	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CEW87_10035	COG0792	nuclease activity
CEW87_10045	COG0418	dihydroorotase activity
CEW87_10060	COG2001	Belongs to the MraZ family
CEW87_10065	COG0275	rRNA processing
CEW87_10080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CEW87_10085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CEW87_10090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CEW87_10095	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CEW87_10100	COG0772	Belongs to the SEDS family
CEW87_10105	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CEW87_10110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CEW87_10115	COG1181	Belongs to the D-alanine--D-alanine ligase family
CEW87_10120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CEW87_10135	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CEW87_10150	COG0653	protein targeting
CEW87_10155	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CEW87_10160	COG3158	transport of potassium into the cell
CEW87_10165	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CEW87_10175	COG2967	ApaG domain
CEW87_10190	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEW87_10195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CEW87_10200	COG1862	Preprotein translocase
CEW87_10205	COG0343	queuine tRNA-ribosyltransferase activity
CEW87_10210	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CEW87_10220	COG0583	DNA-binding transcription factor activity
CEW87_10230	COG0670	Belongs to the BI1 family
CEW87_10235	COG0825	malonyl-CoA metabolic process
CEW87_10240	COG0037	tRNA processing
CEW87_10270	COG1187	pseudouridine synthase activity
CEW87_10275	COG1253	flavin adenine dinucleotide binding
CEW87_10280	COG0861	Integral membrane protein TerC family
CEW87_10295	COG0577	efflux transmembrane transporter activity
CEW87_10295	COG1136	(ABC) transporter
CEW87_10300	COG1136	(ABC) transporter
CEW87_10300	COG0577	efflux transmembrane transporter activity
CEW87_10305	COG0577	efflux transmembrane transporter activity
CEW87_10305	COG1136	(ABC) transporter
CEW87_10315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEW87_10320	COG0668	transmembrane transport
CEW87_10325	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CEW87_10330	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CEW87_10330	COG2885	chlorophyll binding
CEW87_10335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CEW87_10345	COG4647	ligase activity
CEW87_10350	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CEW87_10355	COG0145	ligase activity
CEW87_10360	COG3284	Transcriptional regulator
CEW87_10365	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CEW87_10370	COG0351	phosphomethylpyrimidine kinase
CEW87_10380	COG1136	(ABC) transporter
CEW87_10380	COG0577	efflux transmembrane transporter activity
CEW87_10405	COG0489	protein tyrosine kinase activity
CEW87_10415	COG3409	Peptidoglycan-binding domain 1 protein
CEW87_10415	COG3267	Type II secretory pathway component ExeA
CEW87_10445	COG0367	asparagine synthase
CEW87_10450	COG0438	transferase activity, transferring glycosyl groups
CEW87_10455	COG0367	asparagine synthase
CEW87_10540	COG1216	Glycosyl transferase, family 2
CEW87_10580	COG2026	Addiction module toxin, RelE StbE family
CEW87_10590	COG0367	asparagine synthase
CEW87_10615	COG0318	PFAM AMP-dependent synthetase and ligase
CEW87_10635	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CEW87_10640	COG0071	Belongs to the small heat shock protein (HSP20) family
CEW87_10665	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CEW87_10675	COG0741	lytic transglycosylase activity
CEW87_10685	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CEW87_10690	COG0281	malic enzyme
CEW87_10690	COG0280	phosphate acetyltransferase
CEW87_10710	COG2111	Na H antiporter
CEW87_10710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CEW87_10715	COG1006	Multisubunit Na H antiporter MnhC subunit
CEW87_10720	COG0651	ATP synthesis coupled electron transport
CEW87_10725	COG1863	multisubunit Na H antiporter MnhE subunit
CEW87_10730	COG2212	antiporter activity
CEW87_10735	COG1320	monovalent cation:proton antiporter activity
CEW87_10740	COG1320	monovalent cation:proton antiporter activity
CEW87_10745	COG2212	antiporter activity
CEW87_10765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CEW87_10765	COG2111	Na H antiporter
CEW87_10770	COG0105	UTP biosynthetic process
CEW87_10775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CEW87_10785	COG1426	Protein conserved in bacteria
CEW87_10790	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CEW87_10795	COG0124	histidyl-tRNA synthetase
CEW87_10805	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEW87_10810	COG1160	GTP binding
CEW87_10815	COG1923	regulation of RNA biosynthetic process
CEW87_10820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CEW87_10825	COG0330	HflC and HflK could
CEW87_10830	COG0330	HflC and HflK could
CEW87_10840	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CEW87_10845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CEW87_10860	COG0557	exoribonuclease II activity
CEW87_10865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEW87_10870	COG3707	response regulator
CEW87_10875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CEW87_10875	COG1116	anion transmembrane transporter activity
CEW87_10880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CEW87_10890	COG1116	anion transmembrane transporter activity
CEW87_10900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEW87_10915	COG0517	IMP dehydrogenase activity
CEW87_10920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEW87_10945	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CEW87_10950	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CEW87_10955	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CEW87_10960	COG0723	plastoquinol--plastocyanin reductase activity
CEW87_10965	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CEW87_10970	COG2857	Cytochrome c1
CEW87_10975	COG0625	glutathione transferase activity
CEW87_10980	COG2969	positive regulation of protein catabolic process
CEW87_10985	COG0438	transferase activity, transferring glycosyl groups
CEW87_10995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW87_11000	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CEW87_11010	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CEW87_11015	COG0459	protein refolding
CEW87_11020	COG0745	RESPONSE REGULATOR receiver
CEW87_11025	COG0642	Histidine kinase
CEW87_11030	COG3162	membrane
CEW87_11040	COG0642	Histidine kinase
CEW87_11055	COG3046	protein related to deoxyribodipyrimidine photolyase
CEW87_11060	COG0415	Belongs to the DNA photolyase family
CEW87_11075	COG2902	Dehydrogenase
CEW87_11080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CEW87_11085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CEW87_11090	COG2890	protein-(glutamine-N5) methyltransferase activity
CEW87_11095	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CEW87_11120	COG2815	serine threonine protein kinase
CEW87_11120	COG0515	serine threonine protein kinase
CEW87_11125	COG0165	Argininosuccinate lyase
CEW87_11170	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CEW87_11180	COG0181	hydroxymethylbilane synthase activity
CEW87_11190	COG2959	enzyme of heme biosynthesis
CEW87_11200	COG0659	secondary active sulfate transmembrane transporter activity
CEW87_11205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEW87_11205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEW87_11215	COG0489	protein tyrosine kinase activity
CEW87_11220	COG0717	Belongs to the dCTP deaminase family
CEW87_11225	COG1982	Orn Lys Arg decarboxylase major
CEW87_11235	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CEW87_11380	COG3411	Ferredoxin
CEW87_11395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CEW87_11420	COG1858	cytochrome C peroxidase
CEW87_11445	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CEW87_11450	COG0393	Putative heavy-metal-binding
CEW87_11460	COG0217	transcriptional regulatory protein
CEW87_11465	COG0433	COG0433 Predicted ATPase
CEW87_11470	COG0697	spore germination
CEW87_11480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CEW87_11485	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CEW87_11490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW87_11490	COG3153	acetyltransferase
CEW87_11495	COG3153	acetyltransferase
CEW87_11495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW87_11500	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CEW87_11510	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CEW87_11520	COG1560	Kdo2-lipid A biosynthetic process
CEW87_11530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CEW87_11550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CEW87_11560	COG2255	four-way junction helicase activity
CEW87_11565	COG0632	four-way junction helicase activity
CEW87_11570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CEW87_11580	COG1530	ribonuclease E activity
CEW87_11585	COG0424	maF-like protein
CEW87_11590	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CEW87_11595	COG0799	negative regulation of ribosome biogenesis
CEW87_11600	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CEW87_11615	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CEW87_11640	COG1088	dTDP-glucose 4,6-dehydratase activity
CEW87_11645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CEW87_11655	COG2089	acid synthase
CEW87_11660	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CEW87_11665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEW87_11665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW87_11685	COG1083	cytidylyl-transferase
CEW87_11695	COG2192	nodulation
CEW87_11700	COG1028	Short-chain dehydrogenase reductase Sdr
CEW87_11710	COG2226	methyltransferase
CEW87_11720	COG0110	maltose O-acetyltransferase activity
CEW87_11725	COG0110	maltose O-acetyltransferase activity
CEW87_11735	COG1215	transferase activity, transferring glycosyl groups
CEW87_11740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CEW87_11745	COG1215	transferase activity, transferring glycosyl groups
CEW87_11750	COG1216	Glycosyl transferase, family 2
CEW87_11755	COG0438	transferase activity, transferring glycosyl groups
CEW87_11760	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CEW87_11770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CEW87_11780	COG2192	nodulation
CEW87_11795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CEW87_11800	COG2233	PERMEase
CEW87_11820	COG0708	Exodeoxyribonuclease III
CEW87_11825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CEW87_11835	COG0243	molybdopterin cofactor binding
CEW87_11850	COG0251	oxidation-reduction process
CEW87_11855	COG1238	metal cluster binding
CEW87_11870	COG0037	tRNA processing
CEW87_11875	COG1028	Short-chain dehydrogenase reductase Sdr
CEW87_11890	COG2267	carboxylic ester hydrolase activity
CEW87_11895	COG0625	glutathione transferase activity
CEW87_11905	COG0617	tRNA 3'-terminal CCA addition
CEW87_11920	COG0741	lytic transglycosylase activity
CEW87_11925	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CEW87_11930	COG3447	MASE1 domain protein
CEW87_11930	COG5001	Diguanylate cyclase
CEW87_11930	COG5002	protein histidine kinase activity
CEW87_11940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEW87_11945	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CEW87_11955	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CEW87_11960	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CEW87_11965	COG1137	ATPase activity
CEW87_11970	COG2137	regulation of response to DNA damage stimulus
CEW87_11975	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CEW87_11980	COG1546	Belongs to the CinA family
CEW87_11985	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CEW87_11990	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CEW87_11995	COG3300	MHYT domain
CEW87_11995	COG5001	Diguanylate cyclase
CEW87_12010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CEW87_12020	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CEW87_12025	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CEW87_12030	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CEW87_12045	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CEW87_12050	COG4974	Belongs to the 'phage' integrase family
CEW87_12055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CEW87_12060	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CEW87_12065	COG1466	dna polymerase III delta subunit
CEW87_12075	COG0495	leucyl-tRNA aminoacylation
CEW87_12085	COG0210	DNA helicase
CEW87_12090	COG1192	Involved in chromosome partitioning
CEW87_12095	COG0281	malic enzyme
CEW87_12095	COG0280	phosphate acetyltransferase
CEW87_12110	COG0668	transmembrane transport
CEW87_12120	COG0408	coproporphyrinogen oxidase activity
CEW87_12125	COG3422	double-strand break repair
CEW87_12130	COG0151	Belongs to the GarS family
CEW87_12135	COG0138	bifunctional purine biosynthesis protein purh
CEW87_12140	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CEW87_12150	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEW87_12155	COG0006	proline dipeptidase activity
CEW87_12170	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CEW87_12175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEW87_12180	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CEW87_12185	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CEW87_12205	COG0004	ammonium transporteR
CEW87_12220	COG0339	signal peptide processing
CEW87_12230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CEW87_12245	COG2353	YceI-like domain
CEW87_12255	COG3038	cytochrome b561
CEW87_12260	COG3384	dioxygenase
CEW87_12270	COG3437	response regulator, receiver
CEW87_12290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CEW87_12305	COG0191	fructose-bisphosphate aldolase activity
CEW87_12310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEW87_12320	COG3954	Phosphoribulokinase
CEW87_12335	COG4451	ribulose bisphosphate carboxylase, small
CEW87_12360	COG0469	pyruvate kinase activity
CEW87_12375	COG2205	protein histidine kinase activity
CEW87_12395	COG0126	phosphoglycerate kinase activity
CEW87_12405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEW87_12410	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CEW87_12425	COG0483	inositol monophosphate 1-phosphatase activity
CEW87_12430	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CEW87_12440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CEW87_12440	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CEW87_12450	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CEW87_12455	COG0704	Plays a role in the regulation of phosphate uptake
CEW87_12460	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CEW87_12465	COG0303	'Molybdopterin
CEW87_12470	COG2833	Protein of unknown function (DUF455)
CEW87_12475	COG2863	cytochrome
CEW87_12480	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CEW87_12495	COG2226	methyltransferase
CEW87_12500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CEW87_12505	COG1040	competence protein
CEW87_12510	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CEW87_12515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CEW87_12525	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CEW87_12535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CEW87_12540	COG0640	Transcriptional regulator
CEW87_12545	COG0588	phosphoglycerate mutase activity
CEW87_12555	COG0793	Belongs to the peptidase S41A family
CEW87_12570	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CEW87_12570	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CEW87_12575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CEW87_12580	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CEW87_12600	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW87_12605	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CEW87_12605	COG4651	solute:proton antiporter activity
CEW87_12615	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CEW87_12625	COG0402	S-adenosylhomocysteine deaminase activity
CEW87_12630	COG2815	serine threonine protein kinase
CEW87_12630	COG0515	serine threonine protein kinase
CEW87_12635	COG1950	PFAM Membrane protein of
CEW87_12640	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CEW87_12645	COG1420	regulation of RNA biosynthetic process
CEW87_12650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CEW87_12655	COG0497	DNA recombination
CEW87_12660	COG0735	belongs to the Fur family
CEW87_12665	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CEW87_12670	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CEW87_12675	COG0784	Response regulator, receiver
CEW87_12675	COG2205	protein histidine kinase activity
CEW87_12675	COG5002	protein histidine kinase activity
CEW87_12680	COG0505	Belongs to the CarA family
CEW87_12685	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CEW87_12690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CEW87_12700	COG1534	Rna-binding protein
CEW87_12705	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CEW87_12710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CEW87_12715	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CEW87_12720	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CEW87_12725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CEW87_12730	COG0573	inorganic phosphate transmembrane transporter activity
CEW87_12735	COG0581	inorganic phosphate transmembrane transporter activity
CEW87_12740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CEW87_12750	COG0149	triose-phosphate isomerase activity
CEW87_12765	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEW87_12770	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEW87_12775	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEW87_12780	COG0649	NAD binding
CEW87_12785	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CEW87_12790	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CEW87_12795	COG1034	ATP synthesis coupled electron transport
CEW87_12800	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CEW87_12805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CEW87_12815	COG0713	ATP synthesis coupled electron transport
CEW87_12830	COG1007	ATP synthesis coupled electron transport
CEW87_12855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CEW87_12860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CEW87_12865	COG1129	ABC transporter
CEW87_12865	COG0842	Transport permease protein
CEW87_12870	COG0842	Transport permease protein
CEW87_12890	COG0330	HflC and HflK could
CEW87_12900	COG1126	abc transporter atp-binding protein
CEW87_12905	COG0765	amino acid transport
CEW87_12925	COG2200	EAL domain
CEW87_12945	COG2259	Doxx family
CEW87_12950	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CEW87_12975	COG2409	Drug exporters of the RND superfamily
CEW87_12990	COG1012	belongs to the aldehyde dehydrogenase family
CEW87_12995	COG1522	sequence-specific DNA binding
CEW87_13005	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CEW87_13015	COG1304	FMN binding
CEW87_13025	COG0564	pseudouridine synthase activity
CEW87_13040	COG3243	poly(R)-hydroxyalkanoic acid synthase
CEW87_13045	COG1028	Short-chain dehydrogenase reductase Sdr
CEW87_13055	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CEW87_13060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CEW87_13065	COG1752	Esterase of the alpha-beta hydrolase superfamily
CEW87_13070	COG0277	FAD linked oxidase domain protein
CEW87_13105	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CEW87_13110	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW87_13115	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CEW87_13125	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CEW87_13135	COG0318	PFAM AMP-dependent synthetase and ligase
CEW87_13140	COG0028	Belongs to the TPP enzyme family
CEW87_13145	COG0440	acetolactate synthase activity
CEW87_13150	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CEW87_13160	COG4783	chaperone-mediated protein folding
CEW87_13165	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CEW87_13170	COG0066	3-isopropylmalate dehydratase activity
CEW87_13175	COG0473	3-isopropylmalate dehydrogenase activity
CEW87_13195	COG0101	tRNA pseudouridine synthase activity
CEW87_13200	COG0135	phosphoribosylanthranilate isomerase activity
CEW87_13205	COG0133	tryptophan synthase activity
CEW87_13210	COG0159	tryptophan synthase activity
CEW87_13215	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CEW87_13220	COG0285	dihydrofolate synthase activity
CEW87_13245	COG2239	Acts as a magnesium transporter
CEW87_13255	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW87_13260	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CEW87_13265	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CEW87_13270	COG0215	cysteine-tRNA ligase activity
CEW87_13280	COG0484	heat shock protein binding
CEW87_13285	COG0443	Heat shock 70 kDa protein
CEW87_13290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CEW87_13300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CEW87_13310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CEW87_13315	COG0287	Prephenate dehydrogenase
CEW87_13320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CEW87_13330	COG0776	regulation of translation
CEW87_13340	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CEW87_13380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CEW87_13385	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CEW87_13390	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CEW87_13395	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CEW87_13400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CEW87_13405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CEW87_13405	COG0072	phenylalanine-tRNA ligase activity
CEW87_13410	COG0776	regulation of translation
CEW87_13430	COG0494	nUDIX hydrolase
CEW87_13440	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CEW87_13445	COG1760	l-serine dehydratase
CEW87_13450	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CEW87_13455	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CEW87_13475	COG0298	carbon dioxide binding
CEW87_13485	COG1773	rubredoxin
CEW87_13505	COG0375	protein maturation
CEW87_13515	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CEW87_13520	COG0298	carbon dioxide binding
CEW87_13525	COG0409	Hydrogenase expression formation protein
CEW87_13530	COG0309	Hydrogenase expression formation protein (HypE)
CEW87_13535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CEW87_13535	COG1024	Enoyl-CoA hydratase
CEW87_13540	COG2204	response regulator
CEW87_13545	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CEW87_13555	COG3852	Histidine kinase
CEW87_13565	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CEW87_13570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CEW87_13585	COG2951	lytic endotransglycosylase activity
CEW87_13600	COG0714	Associated with various cellular activities
CEW87_13605	COG0123	including yeast histone deacetylase and acetoin utilization protein
CEW87_13610	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CEW87_13615	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CEW87_13630	COG2850	peptidyl-arginine hydroxylation
CEW87_13635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CEW87_13645	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CEW87_13665	COG0154	amidase activity
CEW87_13670	COG0444	Belongs to the ABC transporter superfamily
CEW87_13675	COG4608	Belongs to the ABC transporter superfamily
CEW87_13680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW87_13685	COG0601	transmembrane transport
CEW87_13690	COG0747	negative chemotaxis
CEW87_13715	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CEW87_13730	COG1191	sigma factor activity
CEW87_13735	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CEW87_13740	COG1360	Flagellar Motor Protein
CEW87_13755	COG0187	DNA topoisomerase II activity
CEW87_13775	COG1815	bacterial-type flagellum-dependent cell motility
CEW87_13780	COG1558	bacterial-type flagellum-dependent cell motility
CEW87_13785	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CEW87_13790	COG1749	Flagellar hook protein flgE
CEW87_13795	COG4787	bacterial-type flagellum-dependent cell motility
CEW87_13800	COG4786	Flagellar basal body rod
CEW87_13805	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CEW87_13810	COG1706	bacterial-type flagellum-dependent cell motility
CEW87_13815	COG3951	Flagellar rod assembly protein muramidase FlgJ
CEW87_13815	COG1705	Flagellar rod assembly protein muramidase FlgJ
CEW87_13820	COG1256	bacterial-type flagellum assembly
CEW87_13840	COG1987	bacterial-type flagellum assembly
CEW87_13855	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CEW87_13870	COG3144	bacterial-type flagellum assembly
CEW87_13880	COG3706	GGDEF domain
CEW87_13885	COG3706	GGDEF domain
CEW87_13895	COG0189	ligase activity
CEW87_13900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW87_13905	COG4215	(ABC) transporter
CEW87_13910	COG4160	amino acid transport
CEW87_13940	COG2814	Major facilitator Superfamily
CEW87_13950	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CEW87_13955	COG0471	metal ion transport
CEW87_13960	COG4181	ATPase activity
CEW87_14015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CEW87_14065	COG4804	nuclease activity
CEW87_14070	COG0514	ATP-dependent DNA helicase (RecQ)
CEW87_14105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CEW87_14115	COG3437	response regulator, receiver
CEW87_14115	COG2205	protein histidine kinase activity
CEW87_14115	COG3850	Histidine kinase
CEW87_14115	COG4999	Histidine kinase
CEW87_14120	COG2205	protein histidine kinase activity
CEW87_14120	COG0784	Response regulator, receiver
CEW87_14120	COG5002	protein histidine kinase activity
CEW87_14135	COG5001	Diguanylate cyclase
CEW87_14135	COG3300	MHYT domain
CEW87_14145	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CEW87_14150	COG0504	CTP synthase activity
CEW87_14155	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CEW87_14160	COG0148	phosphopyruvate hydratase activity
CEW87_14165	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CEW87_14175	COG0791	NLP P60 protein
CEW87_14185	COG0697	spore germination
CEW87_14210	COG2814	Major facilitator Superfamily
CEW87_14215	COG0583	DNA-binding transcription factor activity
CEW87_14230	COG0039	L-malate dehydrogenase activity
CEW87_14250	COG1053	succinate dehydrogenase
CEW87_14255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CEW87_14260	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CEW87_14265	COG0372	Belongs to the citrate synthase family
CEW87_14270	COG0567	Dehydrogenase, E1 component
CEW87_14275	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW87_14280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEW87_14285	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CEW87_14355	COG1199	ATP-dependent helicase activity
CEW87_14360	COG1763	Mo-molybdopterin cofactor biosynthetic process
CEW87_14365	COG0303	'Molybdopterin
CEW87_14370	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CEW87_14375	COG0314	molybdopterin synthase activity
CEW87_14385	COG0741	lytic transglycosylase activity
CEW87_14385	COG1388	LysM domain
CEW87_14390	COG4251	negative regulation of phosphorylation
CEW87_14390	COG5001	Diguanylate cyclase
CEW87_14390	COG2203	Gaf domain
CEW87_14390	COG3706	GGDEF domain
CEW87_14400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEW87_14405	COG2226	methyltransferase
CEW87_14410	COG0328	RNA-DNA hybrid ribonuclease activity
CEW87_14415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CEW87_14420	COG0517	IMP dehydrogenase activity
CEW87_14435	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CEW87_14460	COG1876	peptidase activity
CEW87_14485	COG3045	CreA protein
CEW87_14520	COG0840	transmembrane signaling receptor activity
CEW87_14530	COG2032	superoxide dismutase activity
CEW87_14545	COG4176	ABC-type proline glycine betaine transport system permease component
CEW87_14550	COG2113	Glycine betaine
CEW87_14555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CEW87_14565	COG0330	HflC and HflK could
CEW87_14580	COG0446	pyridine nucleotide-disulphide oxidoreductase
CEW87_14590	COG2197	response regulator
CEW87_14630	COG1294	oxidase, subunit
CEW87_14650	COG0723	plastoquinol--plastocyanin reductase activity
CEW87_14670	COG0450	alkyl hydroperoxide reductase
CEW87_14680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEW87_14695	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW87_14705	COG1522	sequence-specific DNA binding
CEW87_14710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEW87_14720	COG3608	succinylglutamate desuccinylase aspartoacylase
CEW87_14725	COG0006	proline dipeptidase activity
CEW87_14730	COG0006	proline dipeptidase activity
CEW87_14735	COG2423	ornithine cyclodeaminase activity
CEW87_14740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW87_14745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CEW87_14755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW87_14760	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CEW87_14765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW87_14780	COG2989	Protein conserved in bacteria
CEW87_14795	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CEW87_14800	COG0730	response to heat
CEW87_14805	COG0583	DNA-binding transcription factor activity
CEW87_14825	COG3622	Belongs to the hyi family
CEW87_14830	COG0697	spore germination
CEW87_14840	COG4266	Belongs to the allantoicase family
CEW87_14865	COG1953	Uracil, thiamine, allantoin
CEW87_14870	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CEW87_14875	COG4266	Belongs to the allantoicase family
CEW87_14890	COG2351	hydroxyisourate hydrolase activity
CEW87_14905	COG0701	Predicted permease
CEW87_14930	COG1944	ATP diphosphatase activity
CEW87_14950	COG1309	transcriptional regulator
CEW87_14970	COG2860	membrane
CEW87_15020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CEW87_15030	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CEW87_15035	COG0583	DNA-binding transcription factor activity
CEW87_15045	COG2217	Heavy metal translocating P-type atpase
CEW87_15055	COG3278	Belongs to the heme-copper respiratory oxidase family
CEW87_15070	COG2010	Cytochrome c
CEW87_15100	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CEW87_15105	COG3243	poly(R)-hydroxyalkanoic acid synthase
CEW87_15110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CEW87_15115	COG3094	Invasion gene expression up-regulator, SirB
CEW87_15120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CEW87_15125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CEW87_15140	COG2217	Heavy metal translocating P-type atpase
CEW87_15150	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CEW87_15165	COG2130	NADP-dependent
CEW87_15170	COG1979	alcohol dehydrogenase
CEW87_15175	COG1309	transcriptional regulator
CEW87_15190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CEW87_15190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW87_15195	COG0347	Belongs to the P(II) protein family
CEW87_15200	COG2840	Smr protein MutS2
CEW87_15205	COG0492	ferredoxin-NADP+ reductase activity
CEW87_15220	COG1674	ftsk spoiiie
CEW87_15225	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CEW87_15230	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CEW87_15240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CEW87_15245	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CEW87_15250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CEW87_15305	COG0583	DNA-binding transcription factor activity
CEW87_15310	COG2855	membrane
CEW87_15320	COG2188	Transcriptional regulator
CEW87_15325	COG1053	succinate dehydrogenase
CEW87_15340	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CEW87_15345	COG4521	taurine ABC transporter
CEW87_15355	COG1116	anion transmembrane transporter activity
CEW87_15405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CEW87_15405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CEW87_15410	COG1960	acyl-CoA dehydrogenase activity
CEW87_15415	COG0318	PFAM AMP-dependent synthetase and ligase
CEW87_15420	COG1024	Enoyl-CoA hydratase
CEW87_15440	COG2346	COG2346, Truncated hemoglobins
CEW87_15455	COG0753	catalase activity
CEW87_15470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEW87_15475	COG0745	RESPONSE REGULATOR receiver
CEW87_15480	COG0642	Histidine kinase
CEW87_15495	COG4585	Histidine kinase
CEW87_15520	COG0167	dihydroorotate dehydrogenase activity
CEW87_15535	COG1418	mRNA catabolic process
CEW87_15540	COG0348	domain, Protein
CEW87_15545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW87_15565	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CEW87_15570	COG0066	3-isopropylmalate dehydratase activity
CEW87_15580	COG0583	DNA-binding transcription factor activity
CEW87_15585	COG2828	Protein conserved in bacteria
CEW87_15600	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CEW87_15605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CEW87_15625	COG0431	NADPH-dependent FMN reductase
CEW87_15625	COG1053	succinate dehydrogenase
CEW87_15625	COG3976	FMN-binding domain protein
CEW87_15640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEW87_15645	COG2828	Protein conserved in bacteria
CEW87_15670	COG0702	epimerase
CEW87_15690	COG2918	glutathione biosynthetic process
CEW87_15755	COG1222	aaa ATPase
CEW87_15800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEW87_15805	COG0642	Histidine kinase
CEW87_15810	COG0745	RESPONSE REGULATOR receiver
CEW87_15830	COG5001	Diguanylate cyclase
CEW87_15845	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CEW87_15875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW87_15885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CEW87_15890	COG2022	thiamine diphosphate biosynthetic process
CEW87_15900	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CEW87_15905	COG2855	membrane
CEW87_15915	COG1414	Transcriptional regulator
CEW87_15950	COG0697	spore germination
CEW87_15970	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CEW87_15975	COG2823	Periplasmic or secreted lipoprotein
CEW87_16015	COG1414	Transcriptional regulator
CEW87_16020	COG0730	response to heat
CEW87_16035	COG1414	Transcriptional regulator
CEW87_16040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW87_16045	COG0242	peptide deformylase activity
CEW87_16055	COG0583	DNA-binding transcription factor activity
CEW87_16060	COG1960	acyl-CoA dehydrogenase activity
CEW87_16065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CEW87_16080	COG3240	lipase activity
CEW87_16080	COG4625	pathogenesis
CEW87_16085	COG0840	transmembrane signaling receptor activity
CEW87_16100	COG3220	belongs to the UPF0276 family
CEW87_16125	COG2030	dehydratase
CEW87_16125	COG1012	belongs to the aldehyde dehydrogenase family
CEW87_16150	COG0411	ABC transporter
CEW87_16180	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CEW87_16190	COG0411	ABC transporter
CEW87_16205	COG1028	Short-chain dehydrogenase reductase Sdr
CEW87_16210	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CEW87_16215	COG0300	oxidoreductase activity
CEW87_16225	COG0318	PFAM AMP-dependent synthetase and ligase
CEW87_16230	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CEW87_16260	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CEW87_16270	COG0596	Alpha beta hydrolase
CEW87_16270	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW87_16275	COG3384	dioxygenase
CEW87_16280	COG3971	2-oxopent-4-enoate hydratase activity
CEW87_16285	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CEW87_16290	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEW87_16295	COG1063	alcohol dehydrogenase
CEW87_16305	COG1802	Transcriptional regulator
CEW87_16320	COG0346	lactoylglutathione lyase activity
CEW87_16345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW87_16355	COG0633	Ferredoxin
CEW87_16355	COG0543	2 iron, 2 sulfur cluster binding
CEW87_16390	COG1028	Short-chain dehydrogenase reductase Sdr
CEW87_16395	COG0583	DNA-binding transcription factor activity
CEW87_16430	COG0437	4 iron, 4 sulfur cluster binding
CEW87_16445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEW87_16475	COG0840	transmembrane signaling receptor activity
CEW87_16510	COG0559	Belongs to the binding-protein-dependent transport system permease family
CEW87_16520	COG4638	Rieske (2fe-2S)
CEW87_16525	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CEW87_16540	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW87_16580	COG1024	Enoyl-CoA hydratase
CEW87_16590	COG1960	acyl-CoA dehydrogenase activity
CEW87_16605	COG1024	Enoyl-CoA hydratase
CEW87_16610	COG1250	3-hydroxyacyl-CoA dehydrogenase
CEW87_16620	COG0516	GMP reductase activity
CEW87_16640	COG0590	tRNA wobble adenosine to inosine editing
CEW87_16645	COG1376	ErfK ybiS ycfS ynhG family protein
CEW87_16650	COG2153	protein acetylation
CEW87_16670	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CEW87_16675	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CEW87_16690	COG0084	hydrolase, TatD family'
CEW87_16700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CEW87_16710	COG0123	including yeast histone deacetylase and acetoin utilization protein
CEW87_16720	COG2307	Protein conserved in bacteria
CEW87_16720	COG2308	Evidence 4 Homologs of previously reported genes of
CEW87_16730	COG1473	amidohydrolase
CEW87_16735	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CEW87_16745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CEW87_16755	COG1067	ATP-dependent peptidase activity
CEW87_16770	COG0583	DNA-binding transcription factor activity
CEW87_16775	COG2814	Major facilitator Superfamily
CEW87_16795	COG0556	nucleotide-excision repair
CEW87_16800	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CEW87_16805	COG1530	ribonuclease E activity
CEW87_16815	COG0564	pseudouridine synthase activity
CEW87_16820	COG0546	phosphoglycolate phosphatase activity
CEW87_16830	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CEW87_16835	COG0424	maF-like protein
CEW87_16840	COG1399	metal-binding, possibly nucleic acid-binding protein
CEW87_16845	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CEW87_16850	COG0416	fatty acid biosynthetic process
CEW87_16855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CEW87_16860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CEW87_16870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CEW87_16875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CEW87_16885	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CEW87_16910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CEW87_16920	COG0481	GTPase activity
CEW87_16925	COG0681	Belongs to the peptidase S26 family
CEW87_16935	COG0571	ribonuclease III activity
CEW87_16940	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CEW87_16945	COG1381	Involved in DNA repair and RecF pathway recombination
CEW87_16950	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CEW87_16955	COG0736	holo-[acyl-carrier-protein] synthase activity
CEW87_16960	COG1472	Belongs to the glycosyl hydrolase 3 family
CEW87_16965	COG0322	excinuclease ABC activity
CEW87_17000	COG0484	heat shock protein binding
CEW87_17010	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CEW87_17020	COG0850	regulation of cytokinetic process
CEW87_17025	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CEW87_17030	COG1393	Belongs to the ArsC family
CEW87_17035	COG2183	response to ionizing radiation
CEW87_17045	COG0045	succinate-CoA ligase (ADP-forming) activity
CEW87_17045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CEW87_17045	COG1042	CoA-binding domain protein
CEW87_17050	COG2205	protein histidine kinase activity
CEW87_17050	COG2202	Pas domain
CEW87_17060	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CEW87_17065	COG0709	Synthesizes selenophosphate from selenide and ATP
CEW87_17075	COG4181	ATPase activity
CEW87_17080	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CEW87_17085	COG1562	ergosterol biosynthetic process
CEW87_17095	COG1136	(ABC) transporter
CEW87_17110	COG5002	protein histidine kinase activity
CEW87_17110	COG5001	Diguanylate cyclase
CEW87_17130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW87_17135	COG0564	pseudouridine synthase activity
CEW87_17145	COG0583	DNA-binding transcription factor activity
CEW87_17155	COG1573	uracil-dna glycosylase
CEW87_17175	COG0745	RESPONSE REGULATOR receiver
CEW87_17180	COG2205	protein histidine kinase activity
CEW87_17185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CEW87_17195	COG2917	probably involved in intracellular septation
CEW87_17200	COG2350	Protein conserved in bacteria
CEW87_17205	COG0271	Belongs to the BolA IbaG family
CEW87_17210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEW87_17215	COG1960	acyl-CoA dehydrogenase activity
CEW87_17235	COG1309	transcriptional regulator
CEW87_17240	COG0084	hydrolase, TatD family'
CEW87_17245	COG1024	Enoyl-CoA hydratase
CEW87_17250	COG0318	PFAM AMP-dependent synthetase and ligase
CEW87_17265	COG1127	ABC transporter
CEW87_17270	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CEW87_17275	COG0248	Ppx GppA phosphatase
CEW87_17280	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CEW87_17285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEW87_17295	COG0697	spore germination
CEW87_17320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CEW87_17325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CEW87_17335	COG1355	regulation of microtubule-based process
CEW87_17340	COG2078	PFAM AMMECR1 domain protein
CEW87_17340	COG3885	ferrous iron binding
CEW87_17360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CEW87_17365	COG2205	protein histidine kinase activity
CEW87_17370	COG0745	RESPONSE REGULATOR receiver
CEW87_17375	COG2831	hemolysin activation secretion protein
CEW87_17385	COG0598	Magnesium transport protein CorA
CEW87_17395	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CEW87_17400	COG0560	Phosphoserine phosphatase
CEW87_17405	COG2866	Carboxypeptidase
CEW87_17410	COG3022	response to hydroperoxide
CEW87_17415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CEW87_17425	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CEW87_17430	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW87_17435	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW87_17440	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CEW87_17445	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CEW87_17465	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CEW87_17470	COG0575	Belongs to the CDS family
CEW87_17475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CEW87_17480	COG0233	cytoplasmic translational termination
CEW87_17485	COG0528	UMP kinase activity
CEW87_17490	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CEW87_17495	COG0052	Belongs to the universal ribosomal protein uS2 family
CEW87_17500	COG0024	Methionine aminopeptidase
CEW87_17505	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CEW87_17530	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CEW87_17540	COG1196	nuclear chromosome segregation
CEW87_17545	COG0436	Aminotransferase
CEW87_17550	COG2171	N-acyltransferase activity
CEW87_17560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CEW87_17570	COG0784	Response regulator, receiver
CEW87_17580	COG0633	Ferredoxin
CEW87_17585	COG0443	Heat shock 70 kDa protein
CEW87_17590	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CEW87_17600	COG0822	iron-sulfur transferase activity
CEW87_17605	COG1104	cysteine desulfurase activity
CEW87_17610	COG1104	cysteine desulfurase activity
CEW87_17620	COG1045	serine acetyltransferase
CEW87_17700	COG1028	Short-chain dehydrogenase reductase Sdr
CEW87_17705	COG2207	Transcriptional regulator
CEW87_17745	COG3344	reverse transcriptase
CEW87_17750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CEW87_17750	COG0519	Catalyzes the synthesis of GMP from XMP
CEW87_17765	COG2914	Belongs to the UPF0125 (RnfH) family
CEW87_17775	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CEW87_17780	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CEW87_17785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW87_17790	COG0601	transmembrane transport
CEW87_17800	COG3781	membrane
CEW87_17810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEW87_17815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CEW87_17820	COG0509	glycine decarboxylation via glycine cleavage system
CEW87_17825	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CEW87_17825	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CEW87_17840	COG1215	transferase activity, transferring glycosyl groups
CEW87_17850	COG0583	DNA-binding transcription factor activity
CEW87_17860	COG1858	cytochrome C peroxidase
CEW87_17870	COG0386	Belongs to the glutathione peroxidase family
CEW87_17880	COG0488	(ABC) transporter
CEW87_17885	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CEW87_17900	COG0243	molybdopterin cofactor binding
CEW87_17945	COG1136	(ABC) transporter
CEW87_17955	COG1032	radical SAM domain protein
CEW87_17975	COG0537	adenosine 5'-monophosphoramidase activity
CEW87_18000	COG1196	nuclear chromosome segregation
CEW87_18020	COG2814	Major facilitator Superfamily
CEW87_18060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW87_18065	COG0318	PFAM AMP-dependent synthetase and ligase
CEW87_18070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CEW87_18100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CEW87_18105	COG0765	amino acid transport
CEW87_18145	COG1280	lysine exporter protein (LysE YggA)
CEW87_18160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CEW87_18165	COG0318	PFAM AMP-dependent synthetase and ligase
CEW87_18235	COG1794	racemase activity, acting on amino acids and derivatives
CEW87_18245	COG1522	sequence-specific DNA binding
CEW87_18260	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CEW87_18265	COG1309	transcriptional regulator
CEW87_18270	COG1744	ABC transporter substrate-binding protein PnrA-like
CEW87_18290	COG0402	S-adenosylhomocysteine deaminase activity
CEW87_18295	COG1448	Aminotransferase
CEW87_18340	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CEW87_18395	COG1490	D-aminoacyl-tRNA deacylase activity
CEW87_18400	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CEW87_18405	COG3842	ATPase activity
CEW87_18410	COG1176	ABC-type spermidine putrescine transport system, permease component I
CEW87_18415	COG1177	transmembrane transport
CEW87_18420	COG1115	amino acid carrier protein
CEW87_18430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CEW87_18430	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CEW87_18445	COG3447	MASE1 domain protein
CEW87_18445	COG5001	Diguanylate cyclase
CEW87_18445	COG5002	protein histidine kinase activity
CEW87_18450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CEW87_18465	COG3706	GGDEF domain
CEW87_18475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CEW87_18485	COG1192	Involved in chromosome partitioning
CEW87_18505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEW87_18510	COG0587	DNA-directed DNA polymerase activity
CEW87_18520	COG0583	DNA-binding transcription factor activity
CEW87_18525	COG1063	alcohol dehydrogenase
CEW87_18550	COG0436	Aminotransferase
CEW87_18560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CEW87_18565	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CEW87_18570	COG0840	transmembrane signaling receptor activity
CEW87_18585	COG0791	NLP P60 protein
CEW87_18595	COG1840	ABC-type Fe3 transport system, periplasmic component
CEW87_18600	COG1178	ABC-type Fe3 transport system permease component
CEW87_18605	COG3842	ATPase activity
CEW87_18610	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CEW87_18615	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CEW87_18620	COG0167	dihydroorotate dehydrogenase activity
CEW87_18625	COG4657	Part of a membrane complex involved in electron transport
CEW87_18630	COG2878	Part of a membrane complex involved in electron transport
CEW87_18645	COG4659	FMN binding
CEW87_18655	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CEW87_18675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CEW87_18690	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CEW87_18690	COG0426	domain, Protein
CEW87_18695	COG1846	Transcriptional regulator
CEW87_18745	COG0326	Molecular chaperone. Has ATPase activity
CEW87_18760	COG1511	domain protein
CEW87_18760	COG3264	Mechanosensitive ion channel
CEW87_18775	COG0596	Alpha beta hydrolase
CEW87_18790	COG1230	cation diffusion facilitator family transporter
CEW87_18800	COG3135	benzoate transporter
CEW87_18810	COG3259	Nickel-dependent hydrogenase
CEW87_18815	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
CEW87_18820	COG3383	formate dehydrogenase (NAD+) activity
CEW87_18825	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CEW87_18830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CEW87_18840	COG2205	protein histidine kinase activity
CEW87_18840	COG3437	response regulator, receiver
CEW87_18840	COG3850	Histidine kinase
CEW87_18840	COG4999	Histidine kinase
CEW87_18860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEW87_18865	COG0824	Thioesterase
CEW87_18885	COG4771	TonB-dependent receptor
CEW87_18920	COG1999	signal sequence binding
CEW87_18930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CEW87_18930	COG0047	phosphoribosylformylglycinamidine synthase activity
CEW87_18935	COG0671	phosphoesterase, PA-phosphatase related
CEW87_18945	COG0463	Glycosyl transferase, family 2
CEW87_18965	COG0739	heme binding
CEW87_18965	COG0741	lytic transglycosylase activity
CEW87_18965	COG1196	nuclear chromosome segregation
CEW87_18975	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CEW87_18985	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CEW87_18990	COG2267	carboxylic ester hydrolase activity
CEW87_18995	COG2133	pyrroloquinoline quinone binding
CEW87_19005	COG0625	glutathione transferase activity
CEW87_19115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CEW87_19120	COG0006	proline dipeptidase activity
CEW87_19130	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CEW87_19135	COG5002	protein histidine kinase activity
CEW87_19135	COG2176	DNA-directed DNA polymerase activity
CEW87_19145	COG5002	protein histidine kinase activity
CEW87_19155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CEW87_19170	COG2010	Cytochrome c
CEW87_19185	COG2814	Major facilitator Superfamily
CEW87_19225	COG2223	nitrite transmembrane transporter activity
CEW87_19235	COG0535	radical SAM domain protein
CEW87_19240	COG2116	formate transmembrane transporter activity
CEW87_19245	COG0515	serine threonine protein kinase
CEW87_19250	COG1279	arginine transmembrane transporter activity
CEW87_19260	COG0697	spore germination
CEW87_19320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CEW87_19320	COG1648	precorrin-2 dehydrogenase activity
CEW87_19325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CEW87_19335	COG0840	transmembrane signaling receptor activity
CEW87_19355	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CEW87_19360	COG1185	polyribonucleotide nucleotidyltransferase activity
CEW87_19365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CEW87_19370	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CEW87_19375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CEW87_19380	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CEW87_19385	COG2251	uridine kinase activity
CEW87_19385	COG0195	Participates in both transcription termination and antitermination
CEW87_19390	COG0779	Required for maturation of 30S ribosomal subunits
CEW87_19400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CEW87_19405	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CEW87_19410	COG0180	Tryptophanyl-tRNA synthetase
CEW87_19415	COG1994	Peptidase M50
CEW87_19420	COG0009	L-threonylcarbamoyladenylate synthase
CEW87_19425	COG0613	PHP domain protein
CEW87_19440	COG0542	response to heat
CEW87_19455	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CEW87_19460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CEW87_19475	COG2154	pterin-4-alpha-carbinolamine dehydratase
CEW87_19485	COG2081	HI0933 family
CEW87_19520	COG0826	peptidase U32
CEW87_19550	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CEW87_19555	COG1278	Cold shock
CEW87_19560	COG0513	Belongs to the DEAD box helicase family
CEW87_19585	COG4681	YaeQ
CEW87_19600	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CEW87_19610	COG0302	gtp cyclohydrolase
CEW87_19620	COG0306	phosphate transporter
CEW87_19630	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CEW87_19635	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CEW87_19640	COG2233	PERMEase
CEW87_19655	COG4206	TonB-dependent receptor
CEW87_19660	COG4206	TonB-dependent receptor
CEW87_19665	COG2204	response regulator
CEW87_19690	COG0579	oxidoreductase
CEW87_19715	COG3647	Membrane
CEW87_19720	COG0348	domain, Protein
CEW87_19725	COG1959	2 iron, 2 sulfur cluster binding
CEW87_19730	COG0517	IMP dehydrogenase activity
CEW87_19730	COG0516	GMP reductase activity
CEW87_19735	COG2354	Protein conserved in bacteria
CEW87_19755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CEW87_19765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW87_19795	COG1363	Peptidase, m42
CEW87_19840	COG1741	Belongs to the pirin family
CEW87_19855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CEW87_19860	COG1254	Belongs to the acylphosphatase family
CEW87_19870	COG1077	Cell shape determining protein MreB Mrl
CEW87_19880	COG2195	Cleaves the N-terminal amino acid of tripeptides
CEW87_19900	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEW87_19920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CEW87_19925	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CEW87_19935	COG0356	it plays a direct role in the translocation of protons across the membrane
CEW87_19945	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CEW87_19945	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CEW87_19950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CEW87_19960	COG1132	(ABC) transporter
CEW87_19975	COG2814	Major facilitator Superfamily
CEW87_19985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CEW87_19990	COG1272	protein, Hemolysin III
CEW87_20000	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CEW87_20005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CEW87_20010	COG1960	acyl-CoA dehydrogenase activity
CEW87_20025	COG0183	Belongs to the thiolase family
CEW87_20030	COG1024	Enoyl-CoA hydratase
CEW87_20035	COG0318	PFAM AMP-dependent synthetase and ligase
CEW87_20050	COG0411	ABC transporter
CEW87_20075	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW87_20090	COG0583	DNA-binding transcription factor activity
CEW87_20100	COG0667	Aldo Keto reductase
CEW87_20130	COG2159	amidohydrolase
CEW87_20175	COG3706	GGDEF domain
CEW87_20215	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CEW87_20220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CEW87_20225	COG0740	serine-type endopeptidase activity
CEW87_20230	COG0544	peptidyl-prolyl cis-trans isomerase activity
CEW87_20235	COG2766	serine protein kinase
CEW87_20240	COG2718	Belongs to the UPF0229 family
CEW87_20245	COG2719	SpoVR family
CEW87_20250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CEW87_20250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CEW87_20260	COG0697	spore germination
CEW87_20270	COG1595	DNA-templated transcription, initiation
CEW87_20280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CEW87_20310	COG0438	transferase activity, transferring glycosyl groups
CEW87_20325	COG1183	phosphatidylcholine synthase activity
CEW87_20335	COG1403	HNH endonuclease
CEW87_20340	COG3360	Dodecin
CEW87_20375	COG1136	(ABC) transporter
CEW87_20385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CEW87_20395	COG0009	L-threonylcarbamoyladenylate synthase
CEW87_20400	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CEW87_20405	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CEW87_20410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CEW87_20420	COG4566	intracellular signal transduction
CEW87_20435	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CEW87_20440	COG0508	dehydrogenase complex catalyzes the overall conversion of
CEW87_20445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CEW87_20475	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CEW87_20480	COG0802	atpase or kinase
CEW87_20485	COG0860	N-Acetylmuramoyl-L-alanine amidase
CEW87_20490	COG0196	riboflavin kinase activity
CEW87_20495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CEW87_20500	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CEW87_20505	COG1047	Peptidyl-prolyl cis-trans
CEW87_20510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CEW87_20520	COG1722	exodeoxyribonuclease VII activity
CEW87_20525	COG0142	geranyltranstransferase activity
CEW87_20530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CEW87_20535	COG1469	GTP cyclohydrolase I activity
CEW87_20540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CEW87_20550	COG0022	dehydrogenase e1 component
CEW87_20555	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CEW87_20575	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CEW87_20615	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CEW87_20620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CEW87_20625	COG0254	rRNA binding
CEW87_20635	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CEW87_20640	COG0501	Belongs to the peptidase M48B family
CEW87_20660	COG2308	Evidence 4 Homologs of previously reported genes of
CEW87_20665	COG0183	Belongs to the thiolase family
CEW87_20695	COG1666	GTP binding
CEW87_20700	COG3123	guanosine phosphorylase activity
CEW87_20710	COG0137	argininosuccinate synthase activity
CEW87_20715	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CEW87_20720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CEW87_20730	COG0268	Binds directly to 16S ribosomal RNA
CEW87_20740	COG1881	PFAM PEBP family protein
CEW87_20755	COG0563	adenylate kinase activity
CEW87_20760	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CEW87_20765	COG2835	tetraacyldisaccharide 4'-kinase activity
CEW87_20770	COG1663	tetraacyldisaccharide 4'-kinase activity
CEW87_20780	COG0811	peptide transport
CEW87_20785	COG1570	exodeoxyribonuclease VII activity
CEW87_20790	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CEW87_20795	COG0564	pseudouridine synthase activity
CEW87_20805	COG2198	Histidine kinase
CEW87_20805	COG0643	Histidine kinase
CEW87_20810	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CEW87_20815	COG0745	RESPONSE REGULATOR receiver
CEW87_20820	COG0784	Response regulator, receiver
CEW87_20820	COG0835	chemotaxis
CEW87_20825	COG0784	Response regulator, receiver
CEW87_20825	COG0835	chemotaxis
CEW87_20830	COG0840	transmembrane signaling receptor activity
CEW87_20835	COG2201	protein-glutamate methylesterase activity
CEW87_20850	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CEW87_20865	COG3706	GGDEF domain
CEW87_20865	COG0745	RESPONSE REGULATOR receiver
CEW87_20955	COG2226	methyltransferase
CEW87_20960	COG3754	Rhamnan synthesis protein F
CEW87_20980	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CEW87_21000	COG2257	FlhB HrpN YscU SpaS Family
CEW87_21005	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CEW87_21010	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CEW87_21015	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CEW87_21020	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CEW87_21025	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CEW87_21030	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CEW87_21035	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CEW87_21040	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CEW87_21055	COG3181	Tripartite tricarboxylate transporter family receptor
CEW87_21060	COG2721	sulfolactate sulfo-lyase activity
CEW87_21065	COG2721	sulfolactate sulfo-lyase activity
CEW87_21070	COG2188	Transcriptional regulator
CEW87_21075	COG2188	Transcriptional regulator
CEW87_21080	COG2855	membrane
CEW87_21090	COG1609	Transcriptional regulator
CEW87_21100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CEW87_21120	COG1028	Short-chain dehydrogenase reductase Sdr
CEW87_21130	COG1677	Flagellar hook-basal body complex protein FliE
CEW87_21140	COG3852	Histidine kinase
CEW87_21150	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CEW87_21160	COG1157	protein secretion by the type III secretion system
CEW87_21170	COG0402	S-adenosylhomocysteine deaminase activity
CEW87_21185	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CEW87_21185	COG0662	Cupin 2, conserved barrel domain protein
CEW87_21190	COG0175	sulfate reduction
CEW87_21205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CEW87_21225	COG0583	DNA-binding transcription factor activity
CEW87_21240	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CEW87_21250	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CEW87_21275	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CEW87_21280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CEW87_21280	COG0517	IMP dehydrogenase activity
CEW87_21285	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CEW87_21295	COG0110	maltose O-acetyltransferase activity
CEW87_21330	COG1091	dTDP-4-dehydrorhamnose reductase activity
CEW87_21355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CEW87_21360	COG3852	Histidine kinase
CEW87_21395	COG3273	potassium ion transport
CEW87_21395	COG0471	metal ion transport
CEW87_21425	COG2204	response regulator
CEW87_21450	COG3383	formate dehydrogenase (NAD+) activity
CEW87_21515	COG2259	Doxx family
CEW87_21525	COG3220	belongs to the UPF0276 family
CEW87_21550	COG0793	Belongs to the peptidase S41A family
CEW87_21570	COG0527	aspartate kinase activity
CEW87_21585	COG0720	synthase
CEW87_21595	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CEW87_21595	COG3264	Mechanosensitive ion channel
CEW87_21600	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CEW87_21605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CEW87_21605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CEW87_21615	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CEW87_21625	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CEW87_21630	COG1238	metal cluster binding
CEW87_21640	COG3706	GGDEF domain
CEW87_21655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CEW87_21685	COG0028	Belongs to the TPP enzyme family
CEW87_21690	COG0440	acetolactate synthase activity
CEW87_21695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CEW87_21710	COG0745	RESPONSE REGULATOR receiver
CEW87_21720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CEW87_21725	COG1183	phosphatidylcholine synthase activity
CEW87_21740	COG0642	Histidine kinase
CEW87_21750	COG3642	lipopolysaccharide core region biosynthetic process
CEW87_21760	COG2205	protein histidine kinase activity
CEW87_21765	COG0745	RESPONSE REGULATOR receiver
CEW87_21775	COG1858	cytochrome C peroxidase
CEW87_21785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CEW87_21790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CEW87_21805	COG1295	ribonuclease BN
CEW87_21815	COG0228	four-way junction DNA binding
CEW87_21820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CEW87_21825	COG0336	Belongs to the RNA methyltransferase TrmD family
CEW87_21830	COG0335	large ribosomal subunit rRNA binding
CEW87_21840	COG0795	lipopolysaccharide-transporting ATPase activity
CEW87_21845	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CEW87_21860	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CEW87_21870	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CEW87_21875	COG0583	DNA-binding transcription factor activity
CEW87_21880	COG0525	valine-tRNA ligase activity
CEW87_21885	COG0425	Belongs to the sulfur carrier protein TusA family
CEW87_21890	COG4783	chaperone-mediated protein folding
CEW87_21895	COG0315	cyclic pyranopterin monophosphate synthase activity
CEW87_21925	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CEW87_21950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CEW87_21970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CEW87_21975	COG2414	aldehyde ferredoxin oxidoreductase
CEW87_21985	COG3284	Transcriptional regulator
CEW87_22005	COG3038	cytochrome b561
CEW87_22020	COG1012	belongs to the aldehyde dehydrogenase family
CEW87_22025	COG3284	Transcriptional regulator
CEW87_22045	COG0784	Response regulator, receiver
CEW87_22045	COG4191	Histidine kinase
CEW87_22050	COG0318	PFAM AMP-dependent synthetase and ligase
CEW87_22055	COG1960	acyl-CoA dehydrogenase activity
CEW87_22065	COG0659	secondary active sulfate transmembrane transporter activity
CEW87_22085	COG4172	Belongs to the ABC transporter superfamily
CEW87_22090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CEW87_22095	COG0601	transmembrane transport
CEW87_22100	COG0747	negative chemotaxis
CEW87_22110	COG0583	DNA-binding transcription factor activity
CEW87_22130	COG3264	Mechanosensitive ion channel
CEW87_22130	COG1511	domain protein
CEW87_22170	COG0732	type I restriction modification DNA specificity domain
CEW87_22220	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase