locus-tag	class	description
C0099_00055	COG0011	TIGRFAM Protein of
C0099_00075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C0099_00080	COG0022	dehydrogenase e1 component
C0099_00090	COG1960	acyl-CoA dehydrogenase activity
C0099_00095	COG2974	May be involved in recombination
C0099_00105	COG1187	pseudouridine synthase activity
C0099_00115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C0099_00125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C0099_00130	COG1160	GTP binding
C0099_00135	COG0123	including yeast histone deacetylase and acetoin utilization protein
C0099_00145	COG3634	alkyl hydroperoxide reductase activity
C0099_00160	COG0656	L-ascorbic acid biosynthetic process
C0099_00195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C0099_00210	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0099_00215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0099_00255	COG0700	Nucleoside recognition
C0099_00285	COG0589	response to stress
C0099_00290	COG0659	secondary active sulfate transmembrane transporter activity
C0099_00300	COG2226	methyltransferase
C0099_00305	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C0099_00315	COG1335	isochorismatase
C0099_00330	COG0829	nickel cation binding
C0099_00335	COG0831	urea catabolic process
C0099_00340	COG0832	Belongs to the urease beta subunit family
C0099_00345	COG0804	urea catabolic process
C0099_00350	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C0099_00355	COG0830	nickel cation binding
C0099_00360	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C0099_00375	COG0640	Transcriptional regulator
C0099_00380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0099_00385	COG0798	PFAM Bile acid sodium symporter
C0099_00410	COG0019	diaminopimelate decarboxylase activity
C0099_00455	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C0099_00460	COG4133	protoheme IX ABC transporter activity
C0099_00465	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C0099_00480	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C0099_00490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0099_00495	COG3088	subunit of a heme lyase
C0099_00510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C0099_00530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0099_00535	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C0099_00550	COG4232	protein-disulfide reductase activity
C0099_00555	COG1324	tolerance protein
C0099_00570	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C0099_00585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C0099_00600	COG3161	chorismate lyase activity
C0099_00605	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C0099_00615	COG0284	orotidine-5'-phosphate decarboxylase activity
C0099_00620	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C0099_00645	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C0099_00670	COG1965	Belongs to the frataxin family
C0099_00705	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C0099_00710	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C0099_00715	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C0099_00720	COG0070	glutamate synthase
C0099_00720	COG0069	glutamate synthase activity
C0099_00720	COG0067	glutamate synthase
C0099_00730	COG1233	COG1233 Phytoene dehydrogenase and related
C0099_00745	COG0559	Belongs to the binding-protein-dependent transport system permease family
C0099_00760	COG1028	Short-chain dehydrogenase reductase Sdr
C0099_00795	COG0534	Mate efflux family protein
C0099_00810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C0099_00815	COG1959	2 iron, 2 sulfur cluster binding
C0099_00855	COG2233	PERMEase
C0099_00860	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C0099_00865	COG2161	toxin-antitoxin pair type II binding
C0099_00870	COG4115	mRNA cleavage
C0099_00875	COG3093	addiction module antidote protein HigA
C0099_00895	COG1487	ribonuclease activity
C0099_00900	COG4691	Plasmid stability protein
C0099_00905	COG0653	protein targeting
C0099_00910	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C0099_00915	COG1074	ATP-dependent DNA helicase activity
C0099_00920	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C0099_00935	COG1194	a g-specific adenine glycosylase
C0099_00940	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C0099_00950	COG2226	methyltransferase
C0099_00965	COG2022	thiamine diphosphate biosynthetic process
C0099_00970	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C0099_00975	COG0616	signal peptide processing
C0099_00985	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0099_00990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C0099_00995	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C0099_01010	COG1561	YicC-like family, N-terminal region
C0099_01015	COG0194	GDP metabolic process
C0099_01020	COG1758	RNA polymerase activity
C0099_01025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0099_01030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0099_01030	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C0099_01035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0099_01045	COG1671	Belongs to the UPF0178 family
C0099_01060	COG0735	belongs to the Fur family
C0099_01070	COG0523	cobalamin synthesis protein
C0099_01075	COG2176	DNA-directed DNA polymerase activity
C0099_01110	COG0784	Response regulator, receiver
C0099_01110	COG5002	protein histidine kinase activity
C0099_01110	COG2198	Histidine kinase
C0099_01120	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
C0099_01130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0099_01135	COG1132	(ABC) transporter
C0099_01205	COG0625	glutathione transferase activity
C0099_01210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0099_01225	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C0099_01245	COG3093	addiction module antidote protein HigA
C0099_01315	COG1802	Transcriptional regulator
C0099_01320	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C0099_01325	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C0099_01335	COG1802	Transcriptional regulator
C0099_01355	COG4948	Mandelate Racemase Muconate Lactonizing
C0099_01360	COG0179	Fumarylacetoacetate (FAA) hydrolase
C0099_01365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C0099_01370	COG4948	Mandelate Racemase Muconate Lactonizing
C0099_01395	COG3119	arylsulfatase activity
C0099_01405	COG0583	DNA-binding transcription factor activity
C0099_01435	COG0583	DNA-binding transcription factor activity
C0099_01440	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0099_01445	COG1959	2 iron, 2 sulfur cluster binding
C0099_01450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C0099_01450	COG1017	nitric oxide dioxygenase activity
C0099_01455	COG1125	glycine betaine transport
C0099_01455	COG0517	IMP dehydrogenase activity
C0099_01470	COG0778	Nitroreductase
C0099_01520	COG0431	NADPH-dependent FMN reductase
C0099_01530	COG2205	protein histidine kinase activity
C0099_01535	COG0745	RESPONSE REGULATOR receiver
C0099_01550	COG2205	protein histidine kinase activity
C0099_01565	COG0583	DNA-binding transcription factor activity
C0099_01575	COG1335	isochorismatase
C0099_01580	COG1741	Belongs to the pirin family
C0099_01595	COG5001	Diguanylate cyclase
C0099_01595	COG3300	MHYT domain
C0099_01600	COG3012	SEC-C Motif Domain Protein
C0099_01625	COG4266	Belongs to the allantoicase family
C0099_01630	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C0099_01635	COG1802	Transcriptional regulator
C0099_01640	COG0154	amidase activity
C0099_01645	COG0402	S-adenosylhomocysteine deaminase activity
C0099_01685	COG0583	DNA-binding transcription factor activity
C0099_01695	COG1280	lysine exporter protein (LysE YggA)
C0099_01700	COG1024	Enoyl-CoA hydratase
C0099_01705	COG0477	Major facilitator Superfamily
C0099_01715	COG3963	phosphatidate phosphatase activity
C0099_01725	COG0438	transferase activity, transferring glycosyl groups
C0099_01735	COG1902	pentaerythritol trinitrate reductase activity
C0099_01750	COG1136	(ABC) transporter
C0099_01755	COG3447	MASE1 domain protein
C0099_01755	COG5002	protein histidine kinase activity
C0099_01755	COG5001	Diguanylate cyclase
C0099_01770	COG2084	Dehydrogenase
C0099_01775	COG0469	pyruvate kinase activity
C0099_01805	COG3383	formate dehydrogenase (NAD+) activity
C0099_01815	COG3344	reverse transcriptase
C0099_01825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C0099_01840	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0099_01865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C0099_01870	COG0602	queuosine metabolic process
C0099_01885	COG0823	Involved in the tonB-independent uptake of proteins
C0099_01900	COG0811	peptide transport
C0099_01905	COG0824	Thioesterase
C0099_01915	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C0099_01920	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C0099_01940	COG0330	HflC and HflK could
C0099_01955	COG2070	2-Nitropropane dioxygenase
C0099_01960	COG2895	sulfate adenylyltransferase (ATP) activity
C0099_01975	COG0175	sulfate reduction
C0099_01990	COG0583	DNA-binding transcription factor activity
C0099_01995	COG0252	asparaginase activity
C0099_02000	COG5265	(ABC) transporter
C0099_02005	COG1960	acyl-CoA dehydrogenase activity
C0099_02010	COG0183	Belongs to the thiolase family
C0099_02015	COG1024	Enoyl-CoA hydratase
C0099_02015	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0099_02020	COG1607	acyl-coa hydrolase
C0099_02025	COG1024	Enoyl-CoA hydratase
C0099_02025	COG1250	3-hydroxyacyl-CoA dehydrogenase
C0099_02035	COG0625	glutathione transferase activity
C0099_02070	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C0099_02075	COG2755	lipolytic protein G-D-S-L family
C0099_02075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C0099_02080	COG0018	arginyl-trna synthetase
C0099_02100	COG2902	Dehydrogenase
C0099_02115	COG0686	Belongs to the AlaDH PNT family
C0099_02125	COG3243	poly(R)-hydroxyalkanoic acid synthase
C0099_02155	COG1660	Displays ATPase and GTPase activities
C0099_02175	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C0099_02195	COG3447	MASE1 domain protein
C0099_02195	COG5002	protein histidine kinase activity
C0099_02195	COG5001	Diguanylate cyclase
C0099_02220	COG0412	Dienelactone hydrolase
C0099_02230	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C0099_02235	COG0697	spore germination
C0099_02240	COG0217	transcriptional regulatory protein
C0099_02250	COG0433	COG0433 Predicted ATPase
C0099_02260	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C0099_02270	COG3153	acetyltransferase
C0099_02270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0099_02275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0099_02275	COG3153	acetyltransferase
C0099_02280	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C0099_02290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C0099_02300	COG1560	Kdo2-lipid A biosynthetic process
C0099_02305	COG0235	Class ii aldolase
C0099_02310	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C0099_02350	COG2826	transposase and inactivated derivatives, IS30 family
C0099_02365	COG3744	PilT protein domain protein
C0099_02380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C0099_02385	COG4969	Belongs to the N-Me-Phe pilin family
C0099_02405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C0099_02410	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C0099_02420	COG2089	acid synthase
C0099_02435	COG4106	trans-aconitate 2-methyltransferase activity
C0099_02445	COG1083	cytidylyl-transferase
C0099_02455	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C0099_02460	COG1086	Polysaccharide biosynthesis protein
C0099_02465	COG1132	(ABC) transporter
C0099_02495	COG0741	lytic transglycosylase activity
C0099_02510	COG0436	Aminotransferase
C0099_02515	COG0281	malic enzyme
C0099_02515	COG0280	phosphate acetyltransferase
C0099_02520	COG1686	Belongs to the peptidase S11 family
C0099_02525	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C0099_02535	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C0099_02545	COG0803	Belongs to the bacterial solute-binding protein 9 family
C0099_02555	COG1121	(ABC) transporter
C0099_02565	COG1136	(ABC) transporter
C0099_02590	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C0099_02590	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C0099_02595	COG1331	Highly conserved protein containing a thioredoxin domain
C0099_02600	COG4654	Cytochrome c, class I
C0099_02610	COG5002	protein histidine kinase activity
C0099_02615	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C0099_02630	COG1981	membrane
C0099_02660	COG0762	integral membrane protein
C0099_02675	COG0540	Belongs to the ATCase OTCase family
C0099_02685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C0099_02690	COG1678	Uncharacterized ACR, COG1678
C0099_02695	COG0415	Belongs to the DNA photolyase family
C0099_02700	COG2198	Histidine kinase
C0099_02700	COG0643	Histidine kinase
C0099_02705	COG0840	transmembrane signaling receptor activity
C0099_02725	COG1773	rubredoxin
C0099_02730	COG0352	thiamine-phosphate diphosphorylase activity
C0099_02735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C0099_02745	COG2239	Acts as a magnesium transporter
C0099_02750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C0099_02755	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C0099_02765	COG0557	exoribonuclease II activity
C0099_02780	COG3150	esterase
C0099_02785	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
C0099_02785	COG1618	nucleotide phosphatase activity, acting on free nucleotides
C0099_02790	COG0471	metal ion transport
C0099_02790	COG3273	potassium ion transport
C0099_02800	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C0099_02805	COG0351	phosphomethylpyrimidine kinase
C0099_02810	COG2119	membrane
C0099_02840	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0099_02840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C0099_02845	COG1703	isobutyryl-CoA mutase activity
C0099_02850	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C0099_02855	COG4770	biotin carboxylase activity
C0099_02860	COG1509	lysine 2,3-aminomutase activity
C0099_02880	COG0784	Response regulator, receiver
C0099_02880	COG2198	Histidine kinase
C0099_02880	COG2205	protein histidine kinase activity
C0099_02915	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0099_02925	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C0099_02935	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C0099_02940	COG0081	regulation of translation
C0099_02945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C0099_02950	COG0222	ribosome binding
C0099_02955	COG0085	RNA polymerase activity
C0099_02960	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C0099_02965	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C0099_02970	COG0049	tRNA binding
C0099_02975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C0099_02980	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C0099_02985	COG0051	transcription antitermination factor activity, RNA binding
C0099_02990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C0099_02995	COG0088	Forms part of the polypeptide exit tunnel
C0099_03000	COG0089	rRNA binding
C0099_03005	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C0099_03010	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C0099_03015	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C0099_03020	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C0099_03025	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C0099_03030	COG0255	Belongs to the universal ribosomal protein uL29 family
C0099_03035	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C0099_03040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C0099_03045	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C0099_03050	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C0099_03055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C0099_03060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C0099_03065	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C0099_03070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C0099_03075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C0099_03080	COG1841	ribosomal large subunit assembly
C0099_03085	COG0200	Binds to the 23S rRNA
C0099_03090	COG0201	protein transport
C0099_03095	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C0099_03100	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C0099_03105	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C0099_03110	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C0099_03115	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C0099_03120	COG0202	RNA polymerase activity
C0099_03125	COG0203	ribosomal protein L17
C0099_03135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C0099_03155	COG2814	Major facilitator Superfamily
C0099_03160	COG0629	single-stranded DNA binding
C0099_03165	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C0099_03170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0099_03175	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C0099_03190	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C0099_03200	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C0099_03210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0099_03215	COG2084	Dehydrogenase
C0099_03220	COG2084	Dehydrogenase
C0099_03225	COG1414	Transcriptional regulator
C0099_03230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C0099_03235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0099_03235	COG2111	Na H antiporter
C0099_03240	COG1006	Multisubunit Na H antiporter MnhC subunit
C0099_03245	COG0651	ATP synthesis coupled electron transport
C0099_03250	COG1863	multisubunit Na H antiporter MnhE subunit
C0099_03255	COG2212	antiporter activity
C0099_03260	COG1320	monovalent cation:proton antiporter activity
C0099_03265	COG1187	pseudouridine synthase activity
C0099_03270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C0099_03270	COG2111	Na H antiporter
C0099_03275	COG1006	Multisubunit Na H antiporter MnhC subunit
C0099_03280	COG0651	ATP synthesis coupled electron transport
C0099_03285	COG1863	multisubunit Na H antiporter MnhE subunit
C0099_03290	COG2212	antiporter activity
C0099_03295	COG1320	monovalent cation:proton antiporter activity
C0099_03300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0099_03310	COG0668	transmembrane transport
C0099_03315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C0099_03320	COG0493	'glutamate synthase
C0099_03320	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0099_03335	COG1643	Atp-dependent helicase
C0099_03340	COG0360	Binds together with S18 to 16S ribosomal RNA
C0099_03345	COG2965	DNA replication, synthesis of RNA primer
C0099_03350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C0099_03355	COG0359	binds to the 23S rRNA
C0099_03360	COG0305	Participates in initiation and elongation during chromosome replication
C0099_03390	COG2967	ApaG domain
C0099_03405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0099_03410	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C0099_03415	COG1862	Preprotein translocase
C0099_03420	COG0343	queuine tRNA-ribosyltransferase activity
C0099_03425	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C0099_03440	COG0670	Belongs to the BI1 family
C0099_03445	COG0825	malonyl-CoA metabolic process
C0099_03450	COG0037	tRNA processing
C0099_03455	COG4566	intracellular signal transduction
C0099_03470	COG0105	UTP biosynthetic process
C0099_03475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C0099_03485	COG1426	Protein conserved in bacteria
C0099_03490	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C0099_03495	COG0124	histidyl-tRNA synthetase
C0099_03500	COG2976	Protein conserved in bacteria
C0099_03505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0099_03510	COG1160	GTP binding
C0099_03515	COG1923	regulation of RNA biosynthetic process
C0099_03520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C0099_03525	COG0330	HflC and HflK could
C0099_03530	COG0330	HflC and HflK could
C0099_03540	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C0099_03545	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C0099_03555	COG0557	exoribonuclease II activity
C0099_03560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0099_03565	COG3707	response regulator
C0099_03580	COG0243	molybdopterin cofactor binding
C0099_03595	COG0515	serine threonine protein kinase
C0099_03595	COG2815	serine threonine protein kinase
C0099_03600	COG2223	nitrite transmembrane transporter activity
C0099_03605	COG2146	nitrite reductase [NAD(P)H] activity
C0099_03610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C0099_03625	COG1127	ABC transporter
C0099_03630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C0099_03635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0099_03640	COG0842	Transport permease protein
C0099_03640	COG1129	ABC transporter
C0099_03645	COG0842	Transport permease protein
C0099_03660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C0099_03665	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C0099_03670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C0099_03675	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C0099_03680	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C0099_03685	COG0723	plastoquinol--plastocyanin reductase activity
C0099_03690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C0099_03695	COG2857	Cytochrome c1
C0099_03700	COG0625	glutathione transferase activity
C0099_03715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0099_03720	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C0099_03725	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C0099_03725	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
C0099_03725	COG0506	proline dehydrogenase activity
C0099_03750	COG1136	(ABC) transporter
C0099_03765	COG1309	transcriptional regulator
C0099_03770	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C0099_03775	COG0459	protein refolding
C0099_03785	COG0642	Histidine kinase
C0099_03810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
C0099_03815	COG0732	type I restriction modification DNA specificity domain
C0099_03825	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C0099_03915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C0099_03920	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C0099_03925	COG2890	protein-(glutamine-N5) methyltransferase activity
C0099_03930	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C0099_03940	COG3344	reverse transcriptase
C0099_03945	COG3001	Fructosamine kinase
C0099_03950	COG0165	Argininosuccinate lyase
C0099_03955	COG3275	phosphorelay sensor kinase activity
C0099_03965	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C0099_03975	COG0181	hydroxymethylbilane synthase activity
C0099_03985	COG2959	enzyme of heme biosynthesis
C0099_03995	COG0408	coproporphyrinogen oxidase activity
C0099_04000	COG0151	Belongs to the GarS family
C0099_04020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0099_04025	COG0006	proline dipeptidase activity
C0099_04040	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C0099_04045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0099_04050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C0099_04055	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C0099_04075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0099_04100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C0099_04110	COG0463	Glycosyl transferase, family 2
C0099_04135	COG1215	transferase activity, transferring glycosyl groups
C0099_04140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0099_04175	COG1595	DNA-templated transcription, initiation
C0099_04180	COG0114	fumarate hydratase activity
C0099_04185	COG0668	transmembrane transport
C0099_04200	COG0126	phosphoglycerate kinase activity
C0099_04205	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C0099_04210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C0099_04225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C0099_04230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0099_04230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C0099_04235	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C0099_04245	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C0099_04255	COG2833	Protein of unknown function (DUF455)
C0099_04265	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C0099_04280	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C0099_04285	COG1040	competence protein
C0099_04290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C0099_04295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C0099_04305	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C0099_04315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0099_04325	COG0588	phosphoglycerate mutase activity
C0099_04335	COG0793	Belongs to the peptidase S41A family
C0099_04355	COG0318	PFAM AMP-dependent synthetase and ligase
C0099_04370	COG0175	sulfate reduction
C0099_04380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C0099_04390	COG0494	nUDIX hydrolase
C0099_04405	COG2204	response regulator
C0099_04410	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C0099_04435	COG4536	flavin adenine dinucleotide binding
C0099_04445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C0099_04465	COG0346	lactoylglutathione lyase activity
C0099_04490	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C0099_04495	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C0099_04500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C0099_04520	COG2826	transposase and inactivated derivatives, IS30 family
C0099_04535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0099_04540	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C0099_04545	COG1466	dna polymerase III delta subunit
C0099_04555	COG0495	leucyl-tRNA aminoacylation
C0099_04560	COG0210	DNA helicase
C0099_04570	COG1192	Involved in chromosome partitioning
C0099_04585	COG1254	Belongs to the acylphosphatase family
C0099_04590	COG0659	secondary active sulfate transmembrane transporter activity
C0099_04595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0099_04595	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0099_04600	COG0489	protein tyrosine kinase activity
C0099_04605	COG0717	Belongs to the dCTP deaminase family
C0099_04620	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C0099_04655	COG0438	transferase activity, transferring glycosyl groups
C0099_04655	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0099_04665	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C0099_04670	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C0099_04675	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C0099_04685	COG0494	nUDIX hydrolase
C0099_04690	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
C0099_04695	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
C0099_04700	COG0237	dephospho-CoA kinase activity
C0099_04710	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C0099_04715	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C0099_04715	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C0099_04725	COG3852	Histidine kinase
C0099_04735	COG0174	glutamine synthetase
C0099_04740	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C0099_04750	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C0099_04755	COG3568	Endonuclease Exonuclease Phosphatase
C0099_04765	COG1832	CoA-binding protein
C0099_04770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0099_04775	COG0012	GTP binding
C0099_04780	COG0193	aminoacyl-tRNA hydrolase activity
C0099_04785	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C0099_04790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C0099_04800	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C0099_04805	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C0099_04815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C0099_04825	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C0099_04830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C0099_04835	COG0742	ribosomal rna small subunit methyltransferase
C0099_04840	COG0612	Peptidase, M16
C0099_04845	COG0612	Peptidase, M16
C0099_04855	COG2884	Cell division ATP-binding protein ftsE
C0099_04860	COG2177	Part of the ABC transporter FtsEX involved in
C0099_04895	COG0354	folic acid binding
C0099_04900	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C0099_04905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C0099_04920	COG0084	hydrolase, TatD family'
C0099_04930	COG1473	amidohydrolase
C0099_04935	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C0099_04940	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
C0099_04950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C0099_04955	COG1067	ATP-dependent peptidase activity
C0099_04960	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C0099_04985	COG0277	FAD linked oxidase domain protein
C0099_04990	COG0546	phosphoglycolate phosphatase activity
C0099_04990	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C0099_05025	COG0556	nucleotide-excision repair
C0099_05030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C0099_05040	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C0099_05060	COG1530	ribonuclease E activity
C0099_05065	COG0564	pseudouridine synthase activity
C0099_05070	COG0546	phosphoglycolate phosphatase activity
C0099_05075	COG0424	maF-like protein
C0099_05080	COG1399	metal-binding, possibly nucleic acid-binding protein
C0099_05085	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C0099_05090	COG0416	fatty acid biosynthetic process
C0099_05095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C0099_05110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0099_05125	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C0099_05150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0099_05160	COG0481	GTPase activity
C0099_05175	COG0571	ribonuclease III activity
C0099_05180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C0099_05185	COG1381	Involved in DNA repair and RecF pathway recombination
C0099_05190	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C0099_05195	COG0736	holo-[acyl-carrier-protein] synthase activity
C0099_05200	COG1472	Belongs to the glycosyl hydrolase 3 family
C0099_05205	COG0322	excinuclease ABC activity
C0099_05210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C0099_05240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C0099_05255	COG2201	protein-glutamate methylesterase activity
C0099_05260	COG0784	Response regulator, receiver
C0099_05260	COG0835	chemotaxis
C0099_05265	COG0784	Response regulator, receiver
C0099_05265	COG0835	chemotaxis
C0099_05270	COG0745	RESPONSE REGULATOR receiver
C0099_05275	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C0099_05280	COG2198	Histidine kinase
C0099_05280	COG0643	Histidine kinase
C0099_05280	COG0784	Response regulator, receiver
C0099_05285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C0099_05290	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C0099_05295	COG1570	exodeoxyribonuclease VII activity
C0099_05300	COG2358	TRAP transporter, solute receptor (TAXI family
C0099_05315	COG0811	peptide transport
C0099_05320	COG0848	biopolymer transport protein
C0099_05325	COG1663	tetraacyldisaccharide 4'-kinase activity
C0099_05330	COG2835	tetraacyldisaccharide 4'-kinase activity
C0099_05335	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C0099_05340	COG0563	adenylate kinase activity
C0099_05350	COG1368	sulfuric ester hydrolase activity
C0099_05360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C0099_05370	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C0099_05375	COG0598	Magnesium transport protein CorA
C0099_05380	COG0315	cyclic pyranopterin monophosphate synthase activity
C0099_05390	COG0425	Belongs to the sulfur carrier protein TusA family
C0099_05395	COG0525	valine-tRNA ligase activity
C0099_05400	COG3642	lipopolysaccharide core region biosynthetic process
C0099_05415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C0099_05420	COG0795	lipopolysaccharide-transporting ATPase activity
C0099_05430	COG0335	large ribosomal subunit rRNA binding
C0099_05435	COG0336	Belongs to the RNA methyltransferase TrmD family
C0099_05440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C0099_05445	COG0228	four-way junction DNA binding
C0099_05460	COG1183	phosphatidylcholine synthase activity
C0099_05465	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C0099_05470	COG0440	acetolactate synthase activity
C0099_05475	COG0028	Belongs to the TPP enzyme family
C0099_05480	COG1714	RDD family
C0099_05490	COG0308	aminopeptidase N
C0099_05495	COG0129	dihydroxy-acid dehydratase activity
C0099_05500	COG3634	alkyl hydroperoxide reductase activity
C0099_05515	COG2358	TRAP transporter, solute receptor (TAXI family
C0099_05520	COG2175	clavaminate synthase activity
C0099_05525	COG0583	DNA-binding transcription factor activity
C0099_05540	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C0099_05545	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C0099_05550	COG1428	Deoxynucleoside kinase
C0099_05555	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C0099_05570	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C0099_05575	COG0628	permease
C0099_05580	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C0099_05585	COG0300	oxidoreductase activity
C0099_05600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C0099_05605	COG1238	metal cluster binding
C0099_05610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0099_05620	COG2224	Isocitrate lyase
C0099_05625	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C0099_05625	COG2169	Transcriptional regulator
C0099_05640	COG3204	pilus organization
C0099_05655	COG1136	(ABC) transporter
C0099_05660	COG0390	transport system, permease component
C0099_05680	COG2826	transposase and inactivated derivatives, IS30 family
C0099_05695	COG2826	transposase and inactivated derivatives, IS30 family
C0099_05715	COG1944	ATP diphosphatase activity
C0099_05720	COG1960	acyl-CoA dehydrogenase activity
C0099_05735	COG1902	pentaerythritol trinitrate reductase activity
C0099_05755	COG0784	Response regulator, receiver
C0099_05755	COG2198	Histidine kinase
C0099_05755	COG2205	protein histidine kinase activity
C0099_05760	COG3437	response regulator, receiver
C0099_05765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0099_05770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0099_05780	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C0099_05790	COG3622	Belongs to the hyi family
C0099_05795	COG3960	tartronate-semialdehyde synthase activity
C0099_05800	COG0583	DNA-binding transcription factor activity
C0099_05815	COG0697	spore germination
C0099_05820	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C0099_05835	COG0154	amidase activity
C0099_05840	COG1278	Cold shock
C0099_05845	COG3550	peptidyl-serine autophosphorylation
C0099_05860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0099_05865	COG1702	phosphate starvation-inducible protein PhoH
C0099_05870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C0099_05875	COG4535	Mg2 and Co2 transporter CorC
C0099_05880	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C0099_05885	COG0752	glycyl-tRNA synthetase alpha subunit
C0099_05890	COG0751	glycine-tRNA ligase activity
C0099_05895	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C0099_05900	COG0204	Acyl-transferase
C0099_05915	COG1024	Enoyl-CoA hydratase
C0099_05930	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C0099_05940	COG1127	ABC transporter
C0099_05945	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C0099_05950	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C0099_05960	COG2854	intermembrane phospholipid transfer
C0099_05970	COG1131	(ABC) transporter
C0099_05975	COG0842	Transport permease protein
C0099_05980	COG0271	Belongs to the BolA IbaG family
C0099_05985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C0099_05990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0099_05995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C0099_06000	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C0099_06010	COG3344	reverse transcriptase
C0099_06015	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0099_06020	COG0131	Imidazoleglycerol-phosphate dehydratase
C0099_06025	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C0099_06030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C0099_06035	COG0107	imidazoleglycerol-phosphate synthase activity
C0099_06040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C0099_06045	COG0140	phosphoribosyl-ATP diphosphatase activity
C0099_06055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0099_06060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C0099_06065	COG0805	protein transport
C0099_06075	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C0099_06080	COG0045	succinate-CoA ligase (ADP-forming) activity
C0099_06085	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C0099_06090	COG1716	ATPase activity
C0099_06095	COG1234	tRNA 3'-trailer cleavage
C0099_06100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C0099_06105	COG0546	phosphoglycolate phosphatase activity
C0099_06115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C0099_06120	COG3246	L-lysine catabolic process to acetate
C0099_06130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C0099_06135	COG0134	indole-3-glycerol-phosphate synthase activity
C0099_06145	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0099_06150	COG0514	ATP-dependent DNA helicase (RecQ)
C0099_06160	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C0099_06175	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
C0099_06185	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C0099_06205	COG0300	oxidoreductase activity
C0099_06220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C0099_06225	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C0099_06255	COG1612	heme a metabolic process
C0099_06260	COG0109	protoheme IX farnesyltransferase activity
C0099_06265	COG1999	signal sequence binding
C0099_06275	COG0546	phosphoglycolate phosphatase activity
C0099_06280	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0099_06290	COG0402	S-adenosylhomocysteine deaminase activity
C0099_06300	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C0099_06310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C0099_06315	COG0287	Prephenate dehydrogenase
C0099_06320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C0099_06330	COG0776	regulation of translation
C0099_06340	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
C0099_06375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C0099_06380	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C0099_06385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C0099_06390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C0099_06395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C0099_06400	COG0072	phenylalanine-tRNA ligase activity
C0099_06400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C0099_06405	COG0776	regulation of translation
C0099_06420	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0099_06425	COG0765	amino acid transport
C0099_06445	COG0765	amino acid transport
C0099_06450	COG1126	abc transporter atp-binding protein
C0099_06455	COG0765	amino acid transport
C0099_06465	COG3647	Membrane
C0099_06485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0099_06490	COG5002	protein histidine kinase activity
C0099_06490	COG2176	DNA-directed DNA polymerase activity
C0099_06495	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0099_06505	COG2239	Acts as a magnesium transporter
C0099_06510	COG0840	transmembrane signaling receptor activity
C0099_06510	COG0840	transmembrane signaling receptor activity
C0099_06515	COG4251	negative regulation of phosphorylation
C0099_06520	COG0784	Response regulator, receiver
C0099_06535	COG1881	PFAM PEBP family protein
C0099_06540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0099_06545	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0099_06550	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C0099_06560	COG4566	intracellular signal transduction
C0099_06570	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C0099_06575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C0099_06580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C0099_06585	COG0009	L-threonylcarbamoyladenylate synthase
C0099_06640	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C0099_06640	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
C0099_06665	COG0546	phosphoglycolate phosphatase activity
C0099_06670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C0099_06690	COG0583	DNA-binding transcription factor activity
C0099_06820	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0099_06820	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C0099_06825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C0099_06830	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C0099_06835	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C0099_06840	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C0099_06845	COG0406	alpha-ribazole phosphatase activity
C0099_06850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C0099_06860	COG0312	modulator of DNA gyrase
C0099_06865	COG3028	Belongs to the UPF0307 family
C0099_06870	COG0521	Mo-molybdopterin cofactor biosynthetic process
C0099_06875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0099_06885	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C0099_06890	COG2096	Adenosyltransferase
C0099_06895	COG5002	protein histidine kinase activity
C0099_06905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C0099_06920	COG0429	hydrolase of the alpha beta-hydrolase fold
C0099_06930	COG0517	IMP dehydrogenase activity
C0099_06930	COG0617	tRNA 3'-terminal CCA addition
C0099_06930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C0099_06940	COG2871	sodium ion transport
C0099_06945	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C0099_06950	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C0099_06960	COG1805	sodium ion transport
C0099_06980	COG0482	sulfurtransferase activity
C0099_07005	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C0099_07015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0099_07020	COG0312	modulator of DNA gyrase
C0099_07030	COG0741	lytic transglycosylase activity
C0099_07035	COG0442	prolyl-tRNA aminoacylation
C0099_07040	COG0494	nUDIX hydrolase
C0099_07050	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C0099_07055	COG1765	OsmC-like protein
C0099_07060	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C0099_07065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C0099_07070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C0099_07075	COG0316	Belongs to the HesB IscA family
C0099_07080	COG0739	heme binding
C0099_07085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C0099_07120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C0099_07130	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C0099_07140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C0099_07145	COG2814	Major facilitator Superfamily
C0099_07150	COG4783	chaperone-mediated protein folding
C0099_07155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C0099_07165	COG0066	3-isopropylmalate dehydratase activity
C0099_07170	COG0473	3-isopropylmalate dehydrogenase activity
C0099_07190	COG0101	tRNA pseudouridine synthase activity
C0099_07195	COG0135	phosphoribosylanthranilate isomerase activity
C0099_07200	COG0133	tryptophan synthase activity
C0099_07205	COG0159	tryptophan synthase activity
C0099_07210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C0099_07215	COG0285	dihydrofolate synthase activity
C0099_07240	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0099_07245	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0099_07250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C0099_07255	COG0215	cysteine-tRNA ligase activity
C0099_07265	COG0484	heat shock protein binding
C0099_07270	COG0443	Heat shock 70 kDa protein
C0099_07275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C0099_07280	COG0515	serine threonine protein kinase
C0099_07280	COG2815	serine threonine protein kinase
C0099_07290	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C0099_07295	COG1420	regulation of RNA biosynthetic process
C0099_07300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C0099_07305	COG0497	DNA recombination
C0099_07310	COG0735	belongs to the Fur family
C0099_07315	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C0099_07320	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C0099_07325	COG0505	Belongs to the CarA family
C0099_07330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0099_07335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C0099_07350	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C0099_07355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0099_07365	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C0099_07370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C0099_07375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C0099_07380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0099_07395	COG0573	inorganic phosphate transmembrane transporter activity
C0099_07405	COG0149	triose-phosphate isomerase activity
C0099_07425	COG1739	Uncharacterized protein family UPF0029
C0099_07430	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C0099_07440	COG0052	Belongs to the universal ribosomal protein uS2 family
C0099_07445	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C0099_07450	COG0528	UMP kinase activity
C0099_07455	COG0233	cytoplasmic translational termination
C0099_07460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C0099_07470	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C0099_07490	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0099_07495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C0099_07500	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0099_07505	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C0099_07510	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C0099_07520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C0099_07525	COG0509	glycine decarboxylation via glycine cleavage system
C0099_07535	COG0613	PHP domain protein
C0099_07540	COG0009	L-threonylcarbamoyladenylate synthase
C0099_07550	COG0180	Tryptophanyl-tRNA synthetase
C0099_07555	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C0099_07560	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C0099_07570	COG0779	Required for maturation of 30S ribosomal subunits
C0099_07575	COG2251	uridine kinase activity
C0099_07575	COG0195	Participates in both transcription termination and antitermination
C0099_07580	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C0099_07585	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C0099_07590	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C0099_07595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C0099_07600	COG1185	polyribonucleotide nucleotidyltransferase activity
C0099_07610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C0099_07680	COG1917	Cupin 2, conserved barrel domain protein
C0099_07685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C0099_07690	COG0456	acetyltransferase
C0099_07700	COG2271	Major facilitator Superfamily
C0099_07705	COG2081	HI0933 family
C0099_07725	COG0587	DNA-directed DNA polymerase activity
C0099_07740	COG3344	reverse transcriptase
C0099_07760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C0099_07765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C0099_07775	COG2203	Gaf domain
C0099_07775	COG3706	GGDEF domain
C0099_07775	COG4251	negative regulation of phosphorylation
C0099_07775	COG5001	Diguanylate cyclase
C0099_07780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C0099_07785	COG2226	methyltransferase
C0099_07790	COG0328	RNA-DNA hybrid ribonuclease activity
C0099_07795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C0099_07805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C0099_07810	COG0483	inositol monophosphate 1-phosphatase activity
C0099_07820	COG1045	serine acetyltransferase
C0099_07835	COG1104	cysteine desulfurase activity
C0099_07840	COG0822	iron-sulfur transferase activity
C0099_07850	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C0099_07855	COG0443	Heat shock 70 kDa protein
C0099_07860	COG0633	Ferredoxin
C0099_07875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C0099_07885	COG2171	N-acyltransferase activity
C0099_07895	COG1196	nuclear chromosome segregation
C0099_07905	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C0099_07925	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
C0099_07930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C0099_07940	COG0583	DNA-binding transcription factor activity
C0099_07945	COG1573	uracil-dna glycosylase
C0099_07955	COG1214	PFAM Peptidase M22, glycoprotease
C0099_07970	COG2205	protein histidine kinase activity
C0099_07980	COG2350	Protein conserved in bacteria
C0099_07990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0099_08005	COG2086	electron transfer activity
C0099_08010	COG0084	hydrolase, TatD family'
C0099_08015	COG0248	Ppx GppA phosphatase
C0099_08025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C0099_08035	COG3228	Belongs to the MtfA family
C0099_08045	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C0099_08050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C0099_08055	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C0099_08060	COG1355	regulation of microtubule-based process
C0099_08065	COG2078	PFAM AMMECR1 domain protein
C0099_08085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C0099_08090	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C0099_08095	COG0560	Phosphoserine phosphatase
C0099_08100	COG3022	response to hydroperoxide
C0099_08110	COG0156	8-amino-7-oxononanoate synthase activity
C0099_08115	COG2267	carboxylic ester hydrolase activity
C0099_08120	COG2226	methyltransferase
C0099_08125	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
C0099_08130	COG0471	metal ion transport
C0099_08170	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C0099_08175	COG3657	addiction module killer protein
C0099_08180	COG1132	(ABC) transporter
C0099_08190	COG1215	transferase activity, transferring glycosyl groups
C0099_08200	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C0099_08205	COG0488	(ABC) transporter
C0099_08215	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C0099_08220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0099_08225	COG1393	Belongs to the ArsC family
C0099_08235	COG2116	formate transmembrane transporter activity
C0099_08265	COG2264	protein methyltransferase activity
C0099_08270	COG0531	amino acid
C0099_08280	COG2133	pyrroloquinoline quinone binding
C0099_08300	COG3360	Dodecin
C0099_08305	COG1178	ABC-type Fe3 transport system permease component
C0099_08310	COG3842	ATPase activity
C0099_08315	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C0099_08320	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C0099_08325	COG0167	dihydroorotate dehydrogenase activity
C0099_08330	COG4657	Part of a membrane complex involved in electron transport
C0099_08335	COG2878	Part of a membrane complex involved in electron transport
C0099_08350	COG4659	FMN binding
C0099_08360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C0099_08365	COG1704	LemA family
C0099_08370	COG0501	Belongs to the peptidase M48B family
C0099_08385	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C0099_08400	COG0326	Molecular chaperone. Has ATPase activity
C0099_08430	COG1230	cation diffusion facilitator family transporter
C0099_08435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C0099_08460	COG1028	Short-chain dehydrogenase reductase Sdr
C0099_08470	COG1522	sequence-specific DNA binding
C0099_08480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0099_08485	COG0471	metal ion transport
C0099_08485	COG3273	potassium ion transport
C0099_08490	COG2326	polyphosphate kinase activity
C0099_08495	COG2900	Belongs to the SlyX family
C0099_08520	COG3437	response regulator, receiver
C0099_08520	COG2205	protein histidine kinase activity
C0099_08520	COG4999	Histidine kinase
C0099_08520	COG3850	Histidine kinase
C0099_08530	COG3300	MHYT domain
C0099_08530	COG5001	Diguanylate cyclase
C0099_08540	COG0688	phosphatidylethanolamine metabolic process
C0099_08550	COG0582	viral genome integration into host DNA
C0099_08595	COG3154	lipid carrier protein
C0099_08600	COG0826	peptidase U32
C0099_08605	COG0826	peptidase U32
C0099_08610	COG2197	response regulator
C0099_08615	COG3850	Histidine kinase
C0099_08620	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0099_08625	COG2181	nitrate reductase activity
C0099_08630	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C0099_08635	COG1140	nitrate reductase beta subunit
C0099_08640	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C0099_08645	COG2223	nitrite transmembrane transporter activity
C0099_08695	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C0099_08710	COG4263	nitrous-oxide reductase activity
C0099_08715	COG0348	domain, Protein
C0099_08715	COG3901	Regulator of nitric oxide reductase transcription
C0099_08750	COG3945	hemerythrin HHE cation binding domain
C0099_08775	COG1136	(ABC) transporter
C0099_08780	COG1562	ergosterol biosynthetic process
C0099_08785	COG1562	ergosterol biosynthetic process
C0099_08790	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C0099_08800	COG1959	2 iron, 2 sulfur cluster binding
C0099_08805	COG2010	Cytochrome c
C0099_08810	COG3256	nitric oxide reductase
C0099_08815	COG0714	Associated with various cellular activities
C0099_08840	COG4181	ATPase activity
C0099_08850	COG1487	ribonuclease activity
C0099_08860	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C0099_08870	COG1012	belongs to the aldehyde dehydrogenase family
C0099_08875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C0099_08875	COG1042	CoA-binding domain protein
C0099_08875	COG0045	succinate-CoA ligase (ADP-forming) activity
C0099_08885	COG2183	response to ionizing radiation
C0099_08890	COG1393	Belongs to the ArsC family
C0099_08900	COG0850	regulation of cytokinetic process
C0099_08910	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C0099_08915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C0099_08920	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C0099_08920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C0099_08925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C0099_08945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C0099_08960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C0099_08965	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C0099_08970	COG0740	serine-type endopeptidase activity
C0099_08975	COG0544	peptidyl-prolyl cis-trans isomerase activity
C0099_08980	COG2766	serine protein kinase
C0099_08985	COG2718	Belongs to the UPF0229 family
C0099_08990	COG2719	SpoVR family
C0099_08995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C0099_08995	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C0099_09015	COG3263	regulation of cellular component size
C0099_09025	COG0436	Aminotransferase
C0099_09035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C0099_09040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C0099_09060	COG1840	ABC-type Fe3 transport system, periplasmic component
C0099_09065	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C0099_09085	COG1253	flavin adenine dinucleotide binding
C0099_09090	COG4681	YaeQ
C0099_09100	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0099_09105	COG0302	gtp cyclohydrolase
C0099_09115	COG0306	phosphate transporter
C0099_09125	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C0099_09145	COG1490	D-aminoacyl-tRNA deacylase activity
C0099_09150	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C0099_09155	COG0148	phosphopyruvate hydratase activity
C0099_09160	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C0099_09165	COG0504	CTP synthase activity
C0099_09180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C0099_09190	COG2847	Copper chaperone PCu(A)C
C0099_09210	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C0099_09210	COG0047	phosphoribosylformylglycinamidine synthase activity
C0099_09225	COG0739	heme binding
C0099_09235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C0099_09245	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C0099_09260	COG1136	(ABC) transporter
C0099_09275	COG3047	cAMP biosynthetic process
C0099_09280	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C0099_09285	COG2010	Cytochrome c
C0099_09290	COG3256	nitric oxide reductase
C0099_09325	COG0513	Belongs to the DEAD box helicase family
C0099_09340	COG1199	ATP-dependent helicase activity
C0099_09350	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C0099_09355	COG3657	addiction module killer protein
C0099_09360	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C0099_09365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C0099_09370	COG0508	dehydrogenase complex catalyzes the overall conversion of
C0099_09375	COG0567	Dehydrogenase, E1 component
C0099_09380	COG0372	Belongs to the citrate synthase family
C0099_09385	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C0099_09390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C0099_09395	COG1053	succinate dehydrogenase
C0099_09415	COG0039	L-malate dehydrogenase activity
C0099_09425	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
C0099_09435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C0099_09440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C0099_09445	COG1278	Cold shock
C0099_09450	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C0099_09470	COG0604	alcohol dehydrogenase
C0099_09480	COG0488	(ABC) transporter
C0099_09520	COG0277	FAD linked oxidase domain protein
C0099_09525	COG1752	Esterase of the alpha-beta hydrolase superfamily
C0099_09530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C0099_09545	COG1028	Short-chain dehydrogenase reductase Sdr
C0099_09550	COG3243	poly(R)-hydroxyalkanoic acid synthase
C0099_09565	COG0564	pseudouridine synthase activity
C0099_09585	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
C0099_09600	COG2860	membrane
C0099_09625	COG0720	synthase
C0099_09640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C0099_09640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C0099_09650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C0099_09660	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C0099_09680	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C0099_09685	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C0099_09690	COG0617	tRNA 3'-terminal CCA addition
C0099_09690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C0099_09690	COG0517	IMP dehydrogenase activity
C0099_09700	COG1598	PFAM Uncharacterised protein family UPF0150
C0099_09715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C0099_09720	COG0642	Histidine kinase
C0099_09745	COG0318	PFAM AMP-dependent synthetase and ligase
C0099_09755	COG4941	Belongs to the sigma-70 factor family
C0099_09760	COG3795	YCII-related domain
C0099_09765	COG3530	Putative quorum-sensing-regulated virulence factor
C0099_09770	COG0583	DNA-binding transcription factor activity
C0099_09780	COG3384	dioxygenase
C0099_09790	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0099_09810	COG4191	Histidine kinase
C0099_09825	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C0099_09830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C0099_09845	COG0028	Belongs to the TPP enzyme family
C0099_09850	COG2358	TRAP transporter, solute receptor (TAXI family
C0099_09855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C0099_09865	COG1012	belongs to the aldehyde dehydrogenase family
C0099_09870	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C0099_09875	COG1024	Enoyl-CoA hydratase
C0099_09900	COG1917	Cupin 2, conserved barrel domain protein
C0099_09900	COG2207	Transcriptional regulator
C0099_09930	COG4628	conserved protein (DUF2132)
C0099_09975	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C0099_09980	COG4988	ABC transporter
C0099_09985	COG1294	oxidase, subunit
C0099_09990	COG1271	oxidase subunit
C0099_10015	COG2814	Major facilitator Superfamily
C0099_10020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C0099_10060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C0099_10100	COG0798	PFAM Bile acid sodium symporter
C0099_10135	COG4691	Plasmid stability protein
C0099_10160	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C0099_10160	COG0519	Catalyzes the synthesis of GMP from XMP
C0099_10175	COG2914	Belongs to the UPF0125 (RnfH) family
C0099_10180	COG2867	negative regulation of translational initiation
C0099_10185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C0099_10195	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C0099_10205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0099_10215	COG0542	response to heat
C0099_10225	COG0314	molybdopterin synthase activity
C0099_10230	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C0099_10235	COG0303	'Molybdopterin
C0099_10240	COG1763	Mo-molybdopterin cofactor biosynthetic process
C0099_10250	COG1295	ribonuclease BN
C0099_10265	COG2032	superoxide dismutase activity
C0099_10270	COG0583	DNA-binding transcription factor activity
C0099_10280	COG0473	3-isopropylmalate dehydrogenase activity
C0099_10290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C0099_10330	COG3220	belongs to the UPF0276 family
C0099_10350	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0099_10385	COG1942	4-Oxalocrotonate Tautomerase
C0099_10405	COG0189	ligase activity
C0099_10405	COG4067	protein conserved in archaea
C0099_10435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C0099_10440	COG0601	transmembrane transport
C0099_10450	COG2951	lytic endotransglycosylase activity
C0099_10465	COG0438	transferase activity, transferring glycosyl groups
C0099_10505	COG5002	protein histidine kinase activity
C0099_10515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C0099_10515	COG0617	tRNA 3'-terminal CCA addition
C0099_10515	COG0517	IMP dehydrogenase activity
C0099_10520	COG0419	ATPase involved in DNA repair
C0099_10555	COG2860	membrane
C0099_10560	COG3706	GGDEF domain
C0099_10590	COG0840	transmembrane signaling receptor activity
C0099_10615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C0099_10620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C0099_10625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C0099_10630	COG1674	ftsk spoiiie
C0099_10635	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C0099_10640	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C0099_10650	COG0492	ferredoxin-NADP+ reductase activity
C0099_10665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C0099_10665	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C0099_10690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C0099_10695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C0099_10700	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C0099_10725	COG2010	Cytochrome c
C0099_10740	COG3278	Belongs to the heme-copper respiratory oxidase family
C0099_10750	COG2217	Heavy metal translocating P-type atpase
C0099_10755	COG1802	Transcriptional regulator
C0099_10760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C0099_10800	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C0099_10835	COG2308	Evidence 4 Homologs of previously reported genes of
C0099_10865	COG1192	Involved in chromosome partitioning
C0099_10895	COG2207	Transcriptional regulator
C0099_10895	COG1917	Cupin 2, conserved barrel domain protein
C0099_10920	COG4232	protein-disulfide reductase activity
C0099_10935	COG3179	chitinase
C0099_11115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C0099_11230	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C0099_11245	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C0099_11255	COG0737	Belongs to the 5'-nucleotidase family
C0099_11260	COG2010	Cytochrome c
C0099_11280	COG4654	Cytochrome c, class I
C0099_11285	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C0099_11290	COG0640	Transcriptional regulator
C0099_11300	COG0446	pyridine nucleotide-disulphide oxidoreductase
C0099_11315	COG0756	dUTP diphosphatase activity
C0099_11320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C0099_11325	COG2003	Belongs to the UPF0758 family
C0099_11335	COG2501	S4 domain
C0099_11345	COG0727	PFAM Uncharacterised protein family (UPF0153)
C0099_11355	COG3318	Belongs to the UPF0149 family
C0099_11355	COG3012	SEC-C Motif Domain Protein
C0099_11360	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C0099_11365	COG0254	rRNA binding
C0099_11375	COG0166	Belongs to the GPI family
C0099_11380	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C0099_11395	COG0183	Belongs to the thiolase family
C0099_11520	COG1666	GTP binding
C0099_11525	COG3123	guanosine phosphorylase activity
C0099_11535	COG0137	argininosuccinate synthase activity
C0099_11540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C0099_11545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C0099_11550	COG0268	Binds directly to 16S ribosomal RNA
C0099_11575	COG1160	GTP binding
C0099_11595	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0099_11610	COG0275	rRNA processing
C0099_11615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C0099_11620	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C0099_11625	COG0438	transferase activity, transferring glycosyl groups
C0099_11625	COG1216	Glycosyl transferase, family 2
C0099_11665	COG2257	FlhB HrpN YscU SpaS Family
C0099_11670	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C0099_11675	COG1677	Flagellar hook-basal body complex protein FliE
C0099_11695	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C0099_11730	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C0099_11740	COG1338	Plays a role in the flagellum-specific transport system
C0099_11760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C0099_11770	COG3951	Flagellar rod assembly protein muramidase FlgJ
C0099_11770	COG1705	Flagellar rod assembly protein muramidase FlgJ
C0099_11775	COG1706	bacterial-type flagellum-dependent cell motility
C0099_11780	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C0099_11790	COG4787	bacterial-type flagellum-dependent cell motility
C0099_11800	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C0099_11805	COG1558	bacterial-type flagellum-dependent cell motility
C0099_11855	COG1360	Flagellar Motor Protein
C0099_11860	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C0099_11880	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C0099_11885	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C0099_11910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C0099_11915	COG2850	peptidyl-arginine hydroxylation
C0099_11920	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
C0099_11925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C0099_11930	COG0123	including yeast histone deacetylase and acetoin utilization protein
C0099_11935	COG0714	Associated with various cellular activities
C0099_11950	COG2951	lytic endotransglycosylase activity
C0099_11955	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C0099_11960	COG1388	LysM domain
C0099_11960	COG4942	peptidase
C0099_11965	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C0099_11970	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C0099_11980	COG1278	Cold shock
C0099_11985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C0099_11995	COG0142	geranyltranstransferase activity
C0099_12005	COG0667	Aldo Keto reductase
C0099_12010	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C0099_12015	COG0513	Belongs to the DEAD box helicase family
C0099_12035	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
C0099_12045	COG0247	lactate metabolic process
C0099_12050	COG0277	FAD linked oxidase domain protein
C0099_12055	COG0277	FAD linked oxidase domain protein
C0099_12095	COG2188	Transcriptional regulator
C0099_12105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C0099_12110	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C0099_12115	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C0099_12120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C0099_12125	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C0099_12140	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C0099_12150	COG0802	atpase or kinase
C0099_12155	COG0860	N-Acetylmuramoyl-L-alanine amidase
C0099_12160	COG0196	riboflavin kinase activity
C0099_12165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C0099_12170	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C0099_12175	COG1047	Peptidyl-prolyl cis-trans
C0099_12180	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C0099_12190	COG1722	exodeoxyribonuclease VII activity
C0099_12195	COG0142	geranyltranstransferase activity
C0099_12200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C0099_12205	COG1469	GTP cyclohydrolase I activity
C0099_12220	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C0099_12225	COG0653	protein targeting
C0099_12240	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
C0099_12245	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C0099_12255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C0099_12260	COG1181	Belongs to the D-alanine--D-alanine ligase family
C0099_12265	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0099_12270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0099_12275	COG0772	Belongs to the SEDS family
C0099_12280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C0099_12285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0099_12290	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C0099_12295	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C0099_12310	COG0275	rRNA processing
C0099_12315	COG2001	Belongs to the MraZ family
C0099_12330	COG0418	dihydroorotase activity
C0099_12335	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C0099_12340	COG0792	nuclease activity
C0099_12345	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C0099_12355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C0099_12365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0099_12370	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C0099_12375	COG0511	ligase activity, forming carbon-carbon bonds
C0099_12380	COG0439	Biotin carboxylase
C0099_12385	COG2264	protein methyltransferase activity
C0099_12400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C0099_12415	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C0099_12440	COG1054	Belongs to the UPF0176 family
C0099_12460	COG2203	Gaf domain
C0099_12460	COG3706	GGDEF domain
C0099_12460	COG4251	negative regulation of phosphorylation
C0099_12460	COG5001	Diguanylate cyclase
C0099_12465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C0099_12470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C0099_12480	COG1596	polysaccharide export
C0099_12480	COG1555	photosystem II stabilization
C0099_12485	COG1648	precorrin-2 dehydrogenase activity
C0099_12485	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C0099_12490	COG1120	ATPase activity
C0099_12500	COG4206	TonB-dependent receptor
C0099_12505	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
C0099_12515	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C0099_12515	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C0099_12520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0099_12525	COG0859	PFAM glycosyl transferase family 9
C0099_12530	COG0859	PFAM glycosyl transferase family 9
C0099_12535	COG0438	transferase activity, transferring glycosyl groups
C0099_12555	COG1215	transferase activity, transferring glycosyl groups
C0099_12560	COG1404	Belongs to the peptidase S8 family
C0099_12570	COG1132	(ABC) transporter
C0099_12600	COG2192	nodulation
C0099_12640	COG1132	(ABC) transporter
C0099_12660	COG0438	transferase activity, transferring glycosyl groups
C0099_12680	COG0438	transferase activity, transferring glycosyl groups
C0099_12685	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0099_12700	COG2826	transposase and inactivated derivatives, IS30 family
C0099_12710	COG0438	transferase activity, transferring glycosyl groups
C0099_12715	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C0099_12740	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0099_12750	COG0438	transferase activity, transferring glycosyl groups
C0099_12755	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C0099_12780	COG0463	Glycosyl transferase, family 2
C0099_12825	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C0099_12830	COG0438	transferase activity, transferring glycosyl groups
C0099_12830	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C0099_12855	COG3754	Rhamnan synthesis protein F
C0099_12880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C0099_12895	COG1450	Type ii and iii secretion system protein
C0099_12925	COG2165	general secretion pathway protein
C0099_12935	COG2165	general secretion pathway protein
C0099_12940	COG1459	type II secretion system
C0099_12945	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C0099_12955	COG0463	Glycosyl transferase, family 2
C0099_12985	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C0099_12990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C0099_12995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0099_12995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C0099_13010	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C0099_13020	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C0099_13025	COG0799	negative regulation of ribosome biogenesis
C0099_13030	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C0099_13035	COG0424	maF-like protein
C0099_13055	COG0632	four-way junction helicase activity
C0099_13060	COG2255	four-way junction helicase activity
C0099_13070	COG0730	response to heat
C0099_13075	COG4191	Histidine kinase
C0099_13090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C0099_13115	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C0099_13125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C0099_13160	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C0099_13165	COG1136	(ABC) transporter
C0099_13165	COG0577	efflux transmembrane transporter activity
C0099_13175	COG4771	TonB-dependent receptor
C0099_13200	COG2204	response regulator
C0099_13205	COG3852	Histidine kinase
C0099_13235	COG1230	cation diffusion facilitator family transporter
C0099_13250	COG2132	Multicopper oxidase
C0099_13295	COG2217	Heavy metal translocating P-type atpase
C0099_13330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C0099_13350	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C0099_13365	COG0583	DNA-binding transcription factor activity
C0099_13370	COG1032	radical SAM domain protein
C0099_13375	COG3850	Histidine kinase
C0099_13385	COG0840	transmembrane signaling receptor activity
C0099_13385	COG0840	transmembrane signaling receptor activity
C0099_13430	COG0247	lactate metabolic process
C0099_13435	COG1139	Iron-sulfur cluster binding protein
C0099_13455	COG2818	Glycosylase
C0099_13460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C0099_13465	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C0099_13650	COG2369	cell adhesion
C0099_13655	COG4383	Mu-like prophage protein gp29
C0099_13780	COG1426	Protein conserved in bacteria
C0099_13800	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C0099_13810	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C0099_13815	COG2137	regulation of response to DNA damage stimulus
C0099_13820	COG1137	ATPase activity
C0099_13825	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C0099_13830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C0099_13840	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C0099_13845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C0099_13850	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C0099_13860	COG0702	epimerase
C0099_13865	COG0617	tRNA 3'-terminal CCA addition
C0099_13875	COG0625	glutathione transferase activity
C0099_13885	COG1028	Short-chain dehydrogenase reductase Sdr
C0099_13890	COG0037	tRNA processing
C0099_13910	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C0099_13915	COG0708	Exodeoxyribonuclease III
C0099_13925	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C0099_13950	COG1115	amino acid carrier protein
C0099_13965	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C0099_13980	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C0099_13990	COG0477	Major facilitator Superfamily
C0099_14020	COG5001	Diguanylate cyclase
C0099_14020	COG4251	negative regulation of phosphorylation
C0099_14020	COG3706	GGDEF domain
C0099_14020	COG2203	Gaf domain
C0099_14035	COG2208	phosphoserine phosphatase activity
C0099_14035	COG2770	Histidine kinase
C0099_14060	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C0099_14065	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C0099_14085	COG1012	belongs to the aldehyde dehydrogenase family
C0099_14090	COG0006	proline dipeptidase activity
C0099_14095	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C0099_14115	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C0099_14120	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
C0099_14130	COG0583	DNA-binding transcription factor activity
C0099_14150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C0099_14155	COG1984	allophanate hydrolase subunit 2
C0099_14160	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C0099_14170	COG3876	Protein conserved in bacteria
C0099_14185	COG0709	Synthesizes selenophosphate from selenide and ATP
C0099_14210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C0099_14230	COG0004	ammonium transporteR
C0099_14245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0099_14250	COG1115	amino acid carrier protein
C0099_14265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0099_14270	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C0099_14300	COG3932	Exopolysaccharide synthesis, ExoD
C0099_14305	COG1285	pathogenesis
C0099_14315	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C0099_14325	COG0590	tRNA wobble adenosine to inosine editing
C0099_14345	COG2738	Putative neutral zinc metallopeptidase
C0099_14355	COG2826	transposase and inactivated derivatives, IS30 family
C0099_14400	COG0259	pyridoxamine-phosphate oxidase activity
C0099_14410	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C0099_14415	COG3639	organic phosphonate transmembrane transporter activity
C0099_14425	COG2814	Major facilitator Superfamily
C0099_14435	COG4269	membrane
C0099_14445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C0099_14460	COG0405	Gamma-glutamyltransferase
C0099_14465	COG1309	transcriptional regulator
C0099_14475	COG0347	Belongs to the P(II) protein family
C0099_14480	COG0004	ammonium transporteR
C0099_14490	COG2205	protein histidine kinase activity
C0099_14515	COG0488	(ABC) transporter
C0099_14530	COG0189	ligase activity
C0099_14565	COG0501	Belongs to the peptidase M48B family
C0099_14575	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C0099_14585	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C0099_14590	COG3795	YCII-related domain
C0099_14635	COG2132	Multicopper oxidase
C0099_14640	COG1064	alcohol dehydrogenase
C0099_14645	COG2814	Major facilitator Superfamily
C0099_14675	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C0099_14695	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
C0099_14700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C0099_14705	COG1024	Enoyl-CoA hydratase
C0099_14710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C0099_14710	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C0099_14720	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C0099_14725	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C0099_14730	COG1802	Transcriptional regulator
C0099_14740	COG0318	PFAM AMP-dependent synthetase and ligase
C0099_14750	COG0242	peptide deformylase activity
C0099_14755	COG1238	metal cluster binding
C0099_14785	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
C0099_14805	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C0099_14810	COG3657	addiction module killer protein
C0099_14825	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C0099_14830	COG3383	formate dehydrogenase (NAD+) activity
C0099_14845	COG1910	domain protein
C0099_14850	COG0129	dihydroxy-acid dehydratase activity
C0099_14855	COG1047	Peptidyl-prolyl cis-trans
C0099_14870	COG0402	S-adenosylhomocysteine deaminase activity
C0099_14880	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
C0099_14885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C0099_14900	COG0402	S-adenosylhomocysteine deaminase activity
C0099_14905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C0099_14925	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C0099_14935	COG0745	RESPONSE REGULATOR receiver
C0099_14960	COG5487	UPF0391 membrane protein
C0099_14965	COG2823	Periplasmic or secreted lipoprotein
C0099_15000	COG0129	dihydroxy-acid dehydratase activity
C0099_15020	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C0099_15045	COG3181	Tripartite tricarboxylate transporter family receptor
C0099_15100	COG3344	reverse transcriptase
C0099_15125	COG4251	negative regulation of phosphorylation
C0099_15130	COG4968	Prepilin-type N-terminal cleavage methylation domain
C0099_15200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C0099_15205	COG0321	lipoyl(octanoyl) transferase activity
C0099_15210	COG2921	Belongs to the UPF0250 family
C0099_15220	COG1686	Belongs to the peptidase S11 family
C0099_15230	COG0772	Belongs to the SEDS family
C0099_15235	COG0768	penicillin binding
C0099_15250	COG1077	Cell shape determining protein MreB Mrl
C0099_15255	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C0099_15260	COG0154	amidase activity
C0099_15265	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C0099_15275	COG2391	methyltransferase activity
C0099_15280	COG0121	glutamine amidotransferase
C0099_15295	COG5002	protein histidine kinase activity
C0099_15300	COG0745	RESPONSE REGULATOR receiver
C0099_15310	COG2226	methyltransferase
C0099_15330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C0099_15335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C0099_15340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C0099_15345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C0099_15350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C0099_15355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C0099_15365	COG0356	it plays a direct role in the translocation of protons across the membrane
C0099_15380	COG1475	DNA binding
C0099_15385	COG1192	Involved in chromosome partitioning
C0099_15390	COG0357	Ribosomal RNA small subunit methyltransferase G
C0099_15395	COG0445	tRNA wobble uridine modification
C0099_15415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C0099_15425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C0099_15450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C0099_15455	COG0746	molybdenum cofactor guanylyltransferase activity
C0099_15475	COG0437	4 iron, 4 sulfur cluster binding
C0099_15515	COG0489	protein tyrosine kinase activity
C0099_15530	COG1763	Mo-molybdopterin cofactor biosynthetic process
C0099_15540	COG4191	Histidine kinase
C0099_15545	COG0501	Belongs to the peptidase M48B family
C0099_15550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C0099_15555	COG0242	peptide deformylase activity
C0099_15565	COG0758	DNA mediated transformation
C0099_15570	COG2922	Belongs to the Smg family
C0099_15585	COG3344	reverse transcriptase
C0099_15590	COG0783	Belongs to the Dps family
C0099_15595	COG0583	DNA-binding transcription factor activity
C0099_15600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C0099_15605	COG3909	cytochrome
C0099_15615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C0099_15645	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C0099_15665	COG0826	peptidase U32
C0099_15675	COG0488	(ABC) transporter
C0099_15680	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C0099_15690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C0099_15695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0099_15700	COG2813	Specifically methylates the guanine in position
C0099_15700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C0099_15715	COG2814	Major facilitator Superfamily
C0099_15725	COG0288	reversible hydration of carbon dioxide
C0099_15730	COG1940	carbohydrate kinase activity
C0099_15740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C0099_15745	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C0099_15755	COG0569	domain protein
C0099_15760	COG2204	response regulator
C0099_15765	COG5000	phosphorelay sensor kinase activity
C0099_15785	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C0099_15790	COG0706	membrane insertase activity
C0099_15795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C0099_15800	COG0594	ribonuclease P activity
C0099_15805	COG0230	Belongs to the bacterial ribosomal protein bL34 family