locus-tag	class	description
azo0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
azo0004	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
azo0011	COG1028	Short-chain dehydrogenase reductase Sdr
azo0012	COG0583	DNA-binding transcription factor activity
azo0013	COG0564	pseudouridine synthase activity
azo0018	COG0693	protein deglycase activity
azo0023	COG3608	succinylglutamate desuccinylase aspartoacylase
azo0023	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
azo0025	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
azo0026	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
azo0027	COG1216	Glycosyl transferase, family 2
azo0029	COG1253	flavin adenine dinucleotide binding
azo0030	COG0583	DNA-binding transcription factor activity
azo0031	COG0477	Major facilitator Superfamily
azo0039	COG1944	ATP diphosphatase activity
azo0040	COG4977	sequence-specific DNA binding
azo0040	COG1917	Cupin 2, conserved barrel domain protein
azo0043	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
azo0044	COG1984	allophanate hydrolase subunit 2
azo0045	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
azo0046	COG0596	Alpha beta hydrolase
azo0047	COG4676	Protein conserved in bacteria
azo0048	COG4676	Protein conserved in bacteria
azo0049	COG5445	Predicted secreted protein (DUF2300)
azo0053	COG2205	protein histidine kinase activity
azo0054	COG0745	RESPONSE REGULATOR receiver
azo0055	COG1136	(ABC) transporter
azo0056	COG0577	efflux transmembrane transporter activity
azo0059	COG2373	Large extracellular alpha-helical protein
azo0061	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
azo0064	COG0628	permease
azo0066	COG1024	Enoyl-CoA hydratase
azo0072	COG3852	Histidine kinase
azo0074	COG2304	oxidoreductase activity
azo0079	COG1690	Belongs to the RtcB family
azo0080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
azo0082	COG2974	May be involved in recombination
azo0084	COG1187	pseudouridine synthase activity
azo0086	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
azo0088	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
azo0090	COG3909	cytochrome
azo0091	COG0840	transmembrane signaling receptor activity
azo0092	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
azo0093	COG4206	TonB-dependent receptor
azo0095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
azo0095	COG0551	DNA topoisomerase type I activity
azo0096	COG2922	Belongs to the Smg family
azo0097	COG0758	DNA mediated transformation
azo0099	COG0242	peptide deformylase activity
azo0100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
azo0102	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
azo0103	COG1305	Transglutaminase-like
azo0109	COG1490	D-aminoacyl-tRNA deacylase activity
azo0110	COG1741	Belongs to the pirin family
azo0112	COG0583	DNA-binding transcription factor activity
azo0113	COG0625	glutathione transferase activity
azo0115	COG2030	dehydratase
azo0116	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
azo0122	COG0820	rRNA (adenine-C2-)-methyltransferase activity
azo0129	COG0840	transmembrane signaling receptor activity
azo0130	COG0840	transmembrane signaling receptor activity
azo0131	COG1942	4-Oxalocrotonate Tautomerase
azo0132	COG0583	DNA-binding transcription factor activity
azo0134	COG3706	GGDEF domain
azo0141	COG0445	tRNA wobble uridine modification
azo0142	COG0357	Ribosomal RNA small subunit methyltransferase G
azo0143	COG1192	Involved in chromosome partitioning
azo0146	COG1475	DNA binding
azo0148	COG0477	Major facilitator Superfamily
azo0151	COG0640	Transcriptional regulator
azo0153	COG0356	it plays a direct role in the translocation of protons across the membrane
azo0155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
azo0156	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
azo0157	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
azo0158	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
azo0159	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
azo0160	COG0355	proton-transporting ATP synthase activity, rotational mechanism
azo0162	COG2226	methyltransferase
azo0164	COG0745	RESPONSE REGULATOR receiver
azo0168	COG0121	glutamine amidotransferase
azo0170	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
azo0172	COG0154	amidase activity
azo0173	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
azo0174	COG1077	Cell shape determining protein MreB Mrl
azo0177	COG0768	penicillin binding
azo0178	COG0772	Belongs to the SEDS family
azo0180	COG1686	Belongs to the peptidase S11 family
azo0182	COG2921	Belongs to the UPF0250 family
azo0183	COG0321	lipoyl(octanoyl) transferase activity
azo0184	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
azo0189	COG1028	Short-chain dehydrogenase reductase Sdr
azo0192	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
azo0198	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
azo0198	COG0512	Glutamine amidotransferase of anthranilate synthase
azo0200	COG0419	ATPase involved in DNA repair
azo0205	COG1473	amidohydrolase
azo0206	COG2207	Transcriptional regulator
azo0212	COG1522	sequence-specific DNA binding
azo0215	COG1012	belongs to the aldehyde dehydrogenase family
azo0217	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
azo0219	COG0601	transmembrane transport
azo0220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
azo0236	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
azo0237	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
azo0240	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
azo0245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
azo0246	COG1538	Outer membrane efflux protein
azo0247	COG2193	ferroxidase activity
azo0248	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
azo0263	COG0642	Histidine kinase
azo0264	COG0745	RESPONSE REGULATOR receiver
azo0273	COG1595	DNA-templated transcription, initiation
azo0281	COG1360	Flagellar Motor Protein
azo0285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
azo0289	COG1131	(ABC) transporter
azo0292	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
azo0296	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
azo0298	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
azo0299	COG1012	belongs to the aldehyde dehydrogenase family
azo0300	COG1024	Enoyl-CoA hydratase
azo0301	COG1250	3-hydroxyacyl-CoA dehydrogenase
azo0302	COG2050	protein possibly involved in aromatic compounds catabolism
azo0304	COG3396	Phenylacetate-CoA oxygenase
azo0305	COG3460	Phenylacetate-CoA oxygenase
azo0306	COG3396	Phenylacetate-CoA oxygenase
azo0307	COG2151	metal-sulfur cluster biosynthetic enzyme
azo0308	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
azo0310	COG0183	Belongs to the thiolase family
azo0313	COG0411	ABC transporter
azo0315	COG0776	regulation of translation
azo0316	COG0513	Belongs to the DEAD box helicase family
azo0317	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
azo0318	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
azo0321	COG4232	protein-disulfide reductase activity
azo0322	COG1324	tolerance protein
azo0323	COG2070	2-Nitropropane dioxygenase
azo0325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
azo0327	COG1309	transcriptional regulator
azo0330	COG0583	DNA-binding transcription factor activity
azo0335	COG5001	Diguanylate cyclase
azo0335	COG1716	ATPase activity
azo0336	COG3706	GGDEF domain
azo0338	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
azo0343	COG1192	Involved in chromosome partitioning
azo0346	COG0025	NhaP-type Na H and K H
azo0348	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
azo0348	COG0546	phosphoglycolate phosphatase activity
azo0349	COG2076	Multidrug Resistance protein
azo0361	COG0625	glutathione transferase activity
azo0366	COG1045	serine acetyltransferase
azo0368	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
azo0369	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
azo0370	COG2119	membrane
azo0375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
azo0376	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
azo0377	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
azo0380	COG0018	arginyl-trna synthetase
azo0382	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
azo0383	COG0300	oxidoreductase activity
azo0389	COG3243	poly(R)-hydroxyalkanoic acid synthase
azo0393	COG0183	Belongs to the thiolase family
azo0394	COG1960	acyl-CoA dehydrogenase activity
azo0398	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
azo0399	COG1660	Displays ATPase and GTPase activities
azo0402	COG2201	protein-glutamate methylesterase activity
azo0404	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
azo0405	COG0835	chemotaxis
azo0406	COG0840	transmembrane signaling receptor activity
azo0407	COG0840	transmembrane signaling receptor activity
azo0408	COG2198	Histidine kinase
azo0408	COG0643	Histidine kinase
azo0413	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
azo0414	COG0602	queuosine metabolic process
azo0416	COG2885	chlorophyll binding
azo0417	COG0823	Involved in the tonB-independent uptake of proteins
azo0419	COG0848	biopolymer transport protein
azo0420	COG0811	peptide transport
azo0421	COG0824	Thioesterase
azo0423	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
azo0424	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
azo0426	COG5001	Diguanylate cyclase
azo0426	COG3300	MHYT domain
azo0427	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
azo0428	COG2895	sulfate adenylyltransferase (ATP) activity
azo0429	COG0175	sulfate reduction
azo0430	COG0175	sulfate reduction
azo0433	COG0730	response to heat
azo0434	COG0583	DNA-binding transcription factor activity
azo0439	COG1126	abc transporter atp-binding protein
azo0440	COG0765	amino acid transport
azo0441	COG0765	amino acid transport
azo0442	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
azo0444	COG1793	dna ligase
azo0444	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
azo0445	COG1201	RNA secondary structure unwinding
azo0450	COG5001	Diguanylate cyclase
azo0452	COG3634	alkyl hydroperoxide reductase activity
azo0453	COG5265	(ABC) transporter
azo0455	COG0523	cobalamin synthesis protein
azo0457	COG0745	RESPONSE REGULATOR receiver
azo0458	COG5002	protein histidine kinase activity
azo0459	COG0004	ammonium transporteR
azo0463	COG1960	acyl-CoA dehydrogenase activity
azo0465	COG1024	Enoyl-CoA hydratase
azo0465	COG1250	3-hydroxyacyl-CoA dehydrogenase
azo0466	COG1607	acyl-coa hydrolase
azo0467	COG2067	long-chain fatty acid transport protein
azo0468	COG1250	3-hydroxyacyl-CoA dehydrogenase
azo0468	COG1024	Enoyl-CoA hydratase
azo0469	COG0183	Belongs to the thiolase family
azo0470	COG1024	Enoyl-CoA hydratase
azo0475	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
azo0477	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
azo0478	COG3161	chorismate lyase activity
azo0479	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
azo0481	COG0251	oxidation-reduction process
azo0482	COG1238	metal cluster binding
azo0485	COG0037	tRNA processing
azo0491	COG0625	glutathione transferase activity
azo0493	COG0617	tRNA 3'-terminal CCA addition
azo0496	COG0741	lytic transglycosylase activity
azo0497	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
azo0498	COG3706	GGDEF domain
azo0500	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
azo0501	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
azo0503	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
azo0504	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
azo0506	COG2137	regulation of response to DNA damage stimulus
azo0507	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
azo0508	COG1546	Belongs to the CinA family
azo0509	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
azo0510	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
azo0511	COG2914	Belongs to the UPF0125 (RnfH) family
azo0517	COG4657	Part of a membrane complex involved in electron transport
azo0522	COG2032	superoxide dismutase activity
azo0524	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
azo0526	COG0426	domain, Protein
azo0533	COG3647	Membrane
azo0538	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
azo0545	COG0840	transmembrane signaling receptor activity
azo0571	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
azo0572	COG0393	Putative heavy-metal-binding
azo0574	COG0217	transcriptional regulatory protein
azo0576	COG0433	COG0433 Predicted ATPase
azo0577	COG0583	DNA-binding transcription factor activity
azo0578	COG2814	Major facilitator Superfamily
azo0579	COG0697	spore germination
azo0580	COG0840	transmembrane signaling receptor activity
azo0581	COG2814	Major facilitator Superfamily
azo0582	COG2814	Major facilitator Superfamily
azo0584	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
azo0585	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
azo0587	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
azo0589	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
azo0591	COG1560	Kdo2-lipid A biosynthetic process
azo0592	COG1560	Kdo2-lipid A biosynthetic process
azo0594	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
azo0596	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
azo0598	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
azo0601	COG2255	four-way junction helicase activity
azo0602	COG0632	four-way junction helicase activity
azo0607	COG4774	siderophore transport
azo0608	COG3128	pkhd-type hydroxylase
azo0609	COG1304	FMN binding
azo0611	COG0577	efflux transmembrane transporter activity
azo0611	COG1136	(ABC) transporter
azo0612	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
azo0618	COG4256	Hemin uptake protein
azo0622	COG5001	Diguanylate cyclase
azo0626	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
azo0627	COG3132	Protein of unknown function, DUF480
azo0631	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
azo0632	COG0129	dihydroxy-acid dehydratase activity
azo0634	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
azo0638	COG0247	lactate metabolic process
azo0642	COG1121	(ABC) transporter
azo0644	COG0735	belongs to the Fur family
azo0646	COG2274	protein secretion by the type I secretion system
azo0647	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
azo0652	COG5001	Diguanylate cyclase
azo0652	COG4251	negative regulation of phosphorylation
azo0652	COG2203	Gaf domain
azo0652	COG3706	GGDEF domain
azo0654	COG1538	Outer membrane efflux protein
azo0660	COG1132	(ABC) transporter
azo0661	COG1451	nucleotide metabolic process
azo0663	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
azo0664	COG2267	carboxylic ester hydrolase activity
azo0665	COG2453	phosphatase
azo0665	COG0671	phosphoesterase, PA-phosphatase related
azo0667	COG0204	Acyl-transferase
azo0668	COG4589	Belongs to the CDS family
azo0669	COG3005	denitrification pathway
azo0670	COG3043	anaerobic respiration
azo0671	COG0243	molybdopterin cofactor binding
azo0673	COG4459	periplasmic nitrate reductase
azo0675	COG0559	Belongs to the binding-protein-dependent transport system permease family
azo0679	COG0583	DNA-binding transcription factor activity
azo0680	COG1024	Enoyl-CoA hydratase
azo0681	COG3162	membrane
azo0682	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
azo0683	COG1253	flavin adenine dinucleotide binding
azo0684	COG1802	Transcriptional regulator
azo0685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
azo0685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
azo0686	COG1703	isobutyryl-CoA mutase activity
azo0687	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
azo0688	COG0439	Biotin carboxylase
azo0691	COG2321	neutral zinc metallopeptidase
azo0696	COG1703	isobutyryl-CoA mutase activity
azo0696	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
azo0696	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
azo0700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
azo0702	COG4452	Inner membrane protein CreD
azo0703	COG2205	protein histidine kinase activity
azo0704	COG0745	RESPONSE REGULATOR receiver
azo0705	COG2239	Acts as a magnesium transporter
azo0706	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
azo0707	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
azo0709	COG0557	exoribonuclease II activity
azo0710	COG2226	methyltransferase
azo0711	COG3150	esterase
azo0712	COG1968	undecaprenyl-diphosphatase activity
azo0716	COG1643	Atp-dependent helicase
azo0718	COG0360	Binds together with S18 to 16S ribosomal RNA
azo0719	COG2965	DNA replication, synthesis of RNA primer
azo0720	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
azo0721	COG0359	binds to the 23S rRNA
azo0722	COG0305	Participates in initiation and elongation during chromosome replication
azo0723	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
azo0724	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
azo0725	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
azo0728	COG0494	nUDIX hydrolase
azo0729	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
azo0730	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
azo0731	COG0237	dephospho-CoA kinase activity
azo0733	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
azo0734	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
azo0734	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
azo0736	COG3852	Histidine kinase
azo0741	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
azo0742	COG3568	Endonuclease Exonuclease Phosphatase
azo0743	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
azo0744	COG1832	CoA-binding protein
azo0745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
azo0749	COG0463	Glycosyl transferase, family 2
azo0752	COG0012	GTP binding
azo0753	COG0193	aminoacyl-tRNA hydrolase activity
azo0754	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
azo0755	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
azo0756	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
azo0757	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
azo0759	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
azo0760	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
azo0761	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
azo0762	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
azo0763	COG0742	ribosomal rna small subunit methyltransferase
azo0764	COG0612	Peptidase, M16
azo0765	COG0612	Peptidase, M16
azo0767	COG2884	Cell division ATP-binding protein ftsE
azo0768	COG2177	Part of the ABC transporter FtsEX involved in
azo0770	COG3634	alkyl hydroperoxide reductase activity
azo0772	COG0328	RNA-DNA hybrid ribonuclease activity
azo0775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
azo0778	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
azo0779	COG1702	phosphate starvation-inducible protein PhoH
azo0780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
azo0781	COG4535	Mg2 and Co2 transporter CorC
azo0782	COG0815	Transfers the fatty acyl group on membrane lipoproteins
azo0785	COG0752	glycyl-tRNA synthetase alpha subunit
azo0786	COG0751	glycine-tRNA ligase activity
azo0787	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
azo0788	COG0204	Acyl-transferase
azo0790	COG1024	Enoyl-CoA hydratase
azo0791	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
azo0793	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
azo0805	COG1450	Type ii and iii secretion system protein
azo0806	COG1127	ABC transporter
azo0807	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
azo0808	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
azo0809	COG2853	Lipoprotein
azo0812	COG1131	(ABC) transporter
azo0813	COG0842	Transport permease protein
azo0815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
azo0816	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
azo0817	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
azo0818	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
azo0819	COG0436	Aminotransferase
azo0820	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
azo0821	COG0281	malic enzyme
azo0821	COG0280	phosphate acetyltransferase
azo0823	COG1686	Belongs to the peptidase S11 family
azo0824	COG1414	Transcriptional regulator
azo0826	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
azo0828	COG1187	pseudouridine synthase activity
azo0829	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
azo0832	COG1136	(ABC) transporter
azo0832	COG0577	efflux transmembrane transporter activity
azo0833	COG1136	(ABC) transporter
azo0833	COG0577	efflux transmembrane transporter activity
azo0834	COG0577	efflux transmembrane transporter activity
azo0834	COG1136	(ABC) transporter
azo0836	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
azo0837	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
azo0838	COG2885	chlorophyll binding
azo0839	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
azo0840	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
azo0841	COG0351	phosphomethylpyrimidine kinase
azo0848	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
azo0849	COG0425	Belongs to the sulfur carrier protein TusA family
azo0849	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
azo0853	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
azo0861	COG2264	protein methyltransferase activity
azo0862	COG0439	Biotin carboxylase
azo0864	COG0511	ligase activity, forming carbon-carbon bonds
azo0865	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
azo0866	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
azo0868	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
azo0869	COG2823	Periplasmic or secreted lipoprotein
azo0870	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
azo0871	COG0792	nuclease activity
azo0873	COG0418	dihydroorotase activity
azo0875	COG2001	Belongs to the MraZ family
azo0876	COG0275	rRNA processing
azo0879	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
azo0880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
azo0881	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
azo0882	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
azo0883	COG0772	Belongs to the SEDS family
azo0884	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
azo0885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
azo0886	COG1181	Belongs to the D-alanine--D-alanine ligase family
azo0887	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
azo0889	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
azo0890	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
azo0893	COG0653	protein targeting
azo0895	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
azo0896	COG0631	protein serine/threonine phosphatase activity
azo0900	COG2967	ApaG domain
azo0903	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
azo0904	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
azo0905	COG1862	Preprotein translocase
azo0907	COG0343	queuine tRNA-ribosyltransferase activity
azo0908	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
azo0909	COG0583	DNA-binding transcription factor activity
azo0911	COG0670	Belongs to the BI1 family
azo0912	COG4651	solute:proton antiporter activity
azo0912	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
azo0913	COG1253	flavin adenine dinucleotide binding
azo0914	COG0861	Integral membrane protein TerC family
azo0915	COG0825	malonyl-CoA metabolic process
azo0916	COG0037	tRNA processing
azo0917	COG4566	intracellular signal transduction
azo0922	COG0586	Pfam SNARE associated Golgi protein
azo0923	COG0105	UTP biosynthetic process
azo0924	COG0820	rRNA (adenine-C2-)-methyltransferase activity
azo0927	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
azo0928	COG0124	histidyl-tRNA synthetase
azo0929	COG2976	Protein conserved in bacteria
azo0930	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
azo0931	COG1160	GTP binding
azo0932	COG1923	regulation of RNA biosynthetic process
azo0933	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
azo0934	COG0330	HflC and HflK could
azo0935	COG0330	HflC and HflK could
azo0936	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
azo0937	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
azo0938	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
azo0939	COG0557	exoribonuclease II activity
azo0940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
azo0941	COG3707	response regulator
azo0942	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
azo0944	COG1116	anion transmembrane transporter activity
azo0946	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
azo0947	COG0243	molybdopterin cofactor binding
azo0952	COG0551	DNA topoisomerase type I activity
azo0954	COG0716	FMN binding
azo0956	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
azo0957	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
azo0958	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
azo0959	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
azo0960	COG0723	plastoquinol--plastocyanin reductase activity
azo0961	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
azo0962	COG2857	Cytochrome c1
azo0963	COG0625	glutathione transferase activity
azo0965	COG0438	transferase activity, transferring glycosyl groups
azo0967	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
azo0968	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
azo0971	COG4120	Belongs to the binding-protein-dependent transport system permease family
azo0973	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
azo0974	COG0459	protein refolding
azo0975	COG0745	RESPONSE REGULATOR receiver
azo0976	COG0642	Histidine kinase
azo0977	COG3162	membrane
azo0980	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
azo0981	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
azo0983	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
azo0988	COG0515	serine threonine protein kinase
azo0988	COG2815	serine threonine protein kinase
azo0989	COG0165	Argininosuccinate lyase
azo0990	COG3275	phosphorelay sensor kinase activity
azo0992	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
azo0993	COG0181	hydroxymethylbilane synthase activity
azo0995	COG2959	enzyme of heme biosynthesis
azo0997	COG2186	Transcriptional regulator
azo0998	COG0277	FAD linked oxidase domain protein
azo1000	COG0277	FAD linked oxidase domain protein
azo1001	COG0247	lactate metabolic process
azo1002	COG0631	protein serine/threonine phosphatase activity
azo1003	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
azo1004	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
azo1005	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
azo1008	COG0513	Belongs to the DEAD box helicase family
azo1009	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
azo1010	COG0667	Aldo Keto reductase
azo1012	COG1653	transport
azo1013	COG0584	glycerophosphoryl diester phosphodiesterase
azo1014	COG0142	geranyltranstransferase activity
azo1015	COG0583	DNA-binding transcription factor activity
azo1016	COG1304	FMN binding
azo1018	COG0564	pseudouridine synthase activity
azo1021	COG3243	poly(R)-hydroxyalkanoic acid synthase
azo1022	COG1028	Short-chain dehydrogenase reductase Sdr
azo1025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
azo1026	COG1752	Esterase of the alpha-beta hydrolase superfamily
azo1027	COG0277	FAD linked oxidase domain protein
azo1028	COG1250	3-hydroxyacyl-CoA dehydrogenase
azo1029	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
azo1033	COG0318	PFAM AMP-dependent synthetase and ligase
azo1034	COG0028	Belongs to the TPP enzyme family
azo1035	COG0440	acetolactate synthase activity
azo1036	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
azo1037	COG2814	Major facilitator Superfamily
azo1038	COG4783	chaperone-mediated protein folding
azo1039	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
azo1040	COG0066	3-isopropylmalate dehydratase activity
azo1041	COG0473	3-isopropylmalate dehydrogenase activity
azo1045	COG0101	tRNA pseudouridine synthase activity
azo1046	COG0135	phosphoribosylanthranilate isomerase activity
azo1047	COG0133	tryptophan synthase activity
azo1048	COG0159	tryptophan synthase activity
azo1049	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
azo1050	COG0285	dihydrofolate synthase activity
azo1051	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
azo1055	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
azo1056	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
azo1057	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
azo1060	COG0215	cysteine-tRNA ligase activity
azo1062	COG0484	heat shock protein binding
azo1063	COG0443	Heat shock 70 kDa protein
azo1064	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
azo1067	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
azo1070	COG0287	Prephenate dehydrogenase
azo1071	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
azo1073	COG0776	regulation of translation
azo1075	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
azo1079	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
azo1080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
azo1081	COG0291	Belongs to the bacterial ribosomal protein bL35 family
azo1082	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
azo1083	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
azo1084	COG0072	phenylalanine-tRNA ligase activity
azo1084	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
azo1085	COG0776	regulation of translation
azo1087	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
azo1088	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
azo1090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
azo1091	COG2951	lytic endotransglycosylase activity
azo1094	COG0714	Associated with various cellular activities
azo1095	COG0123	including yeast histone deacetylase and acetoin utilization protein
azo1096	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
azo1097	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
azo1099	COG2850	peptidyl-arginine hydroxylation
azo1100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
azo1104	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
azo1107	COG1191	sigma factor activity
azo1108	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
azo1110	COG1360	Flagellar Motor Protein
azo1111	COG2703	oxygen carrier activity
azo1116	COG2860	membrane
azo1120	COG1028	Short-chain dehydrogenase reductase Sdr
azo1122	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
azo1123	COG4638	Rieske (2fe-2S)
azo1125	COG0559	Belongs to the binding-protein-dependent transport system permease family
azo1127	COG0411	ABC transporter
azo1130	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
azo1132	COG0542	response to heat
azo1133	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
azo1134	COG1278	Cold shock
azo1135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
azo1136	COG0227	Belongs to the bacterial ribosomal protein bL28 family
azo1137	COG2003	Belongs to the UPF0758 family
azo1138	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
azo1139	COG0756	dUTP diphosphatase activity
azo1141	COG0446	pyridine nucleotide-disulphide oxidoreductase
azo1145	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
azo1147	COG0538	isocitrate dehydrogenase activity
azo1149	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
azo1154	COG1346	cytolysis
azo1159	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
azo1160	COG0730	response to heat
azo1161	COG0583	DNA-binding transcription factor activity
azo1163	COG3622	Belongs to the hyi family
azo1167	COG1139	Iron-sulfur cluster binding protein
azo1169	COG0247	lactate metabolic process
azo1170	COG2186	Transcriptional regulator
azo1172	COG1278	Cold shock
azo1175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
azo1176	COG2146	nitrite reductase [NAD(P)H] activity
azo1177	COG2116	formate transmembrane transporter activity
azo1178	COG2815	serine threonine protein kinase
azo1178	COG0515	serine threonine protein kinase
azo1180	COG4266	Belongs to the allantoicase family
azo1187	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
azo1188	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
azo1190	COG0535	radical SAM domain protein
azo1195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
azo1196	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
azo1197	COG1469	GTP cyclohydrolase I activity
azo1198	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
azo1199	COG0142	geranyltranstransferase activity
azo1200	COG1722	exodeoxyribonuclease VII activity
azo1202	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
azo1203	COG1047	Peptidyl-prolyl cis-trans
azo1204	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
azo1205	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
azo1206	COG0196	riboflavin kinase activity
azo1208	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
azo1215	COG0803	Belongs to the bacterial solute-binding protein 9 family
azo1216	COG1121	(ABC) transporter
azo1217	COG1108	ABC-type Mn2 Zn2 transport systems permease components
azo1217	COG1321	iron dependent repressor
azo1218	COG1108	ABC-type Mn2 Zn2 transport systems permease components
azo1223	COG0459	protein refolding
azo1226	COG0346	lactoylglutathione lyase activity
azo1231	COG1294	oxidase, subunit
azo1234	COG2204	response regulator
azo1235	COG0723	plastoquinol--plastocyanin reductase activity
azo1236	COG1132	(ABC) transporter
azo1238	COG0644	oxidoreductase
azo1240	COG0641	radical SAM
azo1243	COG0860	N-Acetylmuramoyl-L-alanine amidase
azo1244	COG0802	atpase or kinase
azo1246	COG4948	Mandelate Racemase Muconate Lactonizing
azo1247	COG0583	DNA-binding transcription factor activity
azo1251	COG0826	peptidase U32
azo1253	COG2133	pyrroloquinoline quinone binding
azo1254	COG3300	MHYT domain
azo1254	COG5001	Diguanylate cyclase
azo1255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
azo1256	COG2815	serine threonine protein kinase
azo1256	COG0515	serine threonine protein kinase
azo1259	COG2195	Cleaves the N-terminal amino acid of tripeptides
azo1261	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
azo1262	COG1704	LemA family
azo1263	COG3360	Dodecin
azo1266	COG0484	heat shock protein binding
azo1267	COG1607	acyl-coa hydrolase
azo1268	COG4628	conserved protein (DUF2132)
azo1269	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
azo1273	COG1127	ABC transporter
azo1274	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
azo1275	COG0488	(ABC) transporter
azo1276	COG2226	methyltransferase
azo1277	COG0386	Belongs to the glutathione peroxidase family
azo1279	COG1858	cytochrome C peroxidase
azo1281	COG0583	DNA-binding transcription factor activity
azo1285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
azo1285	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
azo1286	COG0509	glycine decarboxylation via glycine cleavage system
azo1287	COG0404	The glycine cleavage system catalyzes the degradation of glycine
azo1288	COG2223	nitrite transmembrane transporter activity
azo1289	COG2815	serine threonine protein kinase
azo1289	COG0515	serine threonine protein kinase
azo1293	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
azo1295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
azo1296	COG0312	modulator of DNA gyrase
azo1307	COG3501	Rhs element vgr protein
azo1312	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
azo1313	COG2824	Alkylphosphonate utilization operon protein PhnA
azo1315	COG0390	transport system, permease component
azo1316	COG3842	ATPase activity
azo1324	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
azo1327	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
azo1328	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
azo1329	COG0765	amino acid transport
azo1330	COG4597	amino acid ABC transporter
azo1331	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
azo1332	COG0583	DNA-binding transcription factor activity
azo1333	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
azo1334	COG4208	sulfate ABC transporter
azo1335	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
azo1337	COG2951	lytic endotransglycosylase activity
azo1341	COG3278	Belongs to the heme-copper respiratory oxidase family
azo1350	COG3243	poly(R)-hydroxyalkanoic acid synthase
azo1351	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
azo1352	COG0635	Involved in the biosynthesis of porphyrin-containing compound
azo1355	COG2217	Heavy metal translocating P-type atpase
azo1356	COG2608	mercury ion transmembrane transporter activity
azo1358	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
azo1360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
azo1360	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
azo1361	COG0347	Belongs to the P(II) protein family
azo1362	COG2840	Smr protein MutS2
azo1363	COG0492	ferredoxin-NADP+ reductase activity
azo1365	COG1674	ftsk spoiiie
azo1366	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
azo1367	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
azo1369	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
azo1370	COG0840	transmembrane signaling receptor activity
azo1371	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
azo1372	COG0508	dehydrogenase complex catalyzes the overall conversion of
azo1373	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
azo1376	COG4566	intracellular signal transduction
azo1377	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
azo1378	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
azo1379	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
azo1380	COG0009	L-threonylcarbamoyladenylate synthase
azo1381	COG0505	Belongs to the CarA family
azo1382	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
azo1383	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
azo1385	COG1534	Rna-binding protein
azo1386	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
azo1387	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
azo1388	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
azo1389	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
azo1390	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
azo1391	COG0573	inorganic phosphate transmembrane transporter activity
azo1392	COG0581	inorganic phosphate transmembrane transporter activity
azo1393	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
azo1394	COG0149	triose-phosphate isomerase activity
azo1396	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
azo1397	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
azo1398	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
azo1399	COG0649	NAD binding
azo1400	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
azo1402	COG1034	ATP synthesis coupled electron transport
azo1403	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
azo1404	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
azo1406	COG0713	ATP synthesis coupled electron transport
azo1409	COG1007	ATP synthesis coupled electron transport
azo1411	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
azo1412	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
azo1414	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
azo1415	COG3259	Nickel-dependent hydrogenase
azo1418	COG1230	cation diffusion facilitator family transporter
azo1421	COG0596	Alpha beta hydrolase
azo1421	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
azo1421	COG2226	methyltransferase
azo1425	COG0326	Molecular chaperone. Has ATPase activity
azo1428	COG0426	domain, Protein
azo1428	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
azo1435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
azo1438	COG4658	electron transport chain
azo1439	COG4656	Part of a membrane complex involved in electron transport
azo1440	COG2878	Part of a membrane complex involved in electron transport
azo1444	COG0745	RESPONSE REGULATOR receiver
azo1444	COG3706	GGDEF domain
azo1448	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
azo1449	COG1360	Flagellar Motor Protein
azo1451	COG2198	Histidine kinase
azo1451	COG0643	Histidine kinase
azo1453	COG0840	transmembrane signaling receptor activity
azo1454	COG0840	transmembrane signaling receptor activity
azo1456	COG2201	protein-glutamate methylesterase activity
azo1458	COG0835	chemotaxis
azo1458	COG0784	Response regulator, receiver
azo1459	COG0784	Response regulator, receiver
azo1459	COG0835	chemotaxis
azo1460	COG0745	RESPONSE REGULATOR receiver
azo1461	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
azo1462	COG0643	Histidine kinase
azo1462	COG2198	Histidine kinase
azo1464	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
azo1466	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
azo1467	COG1570	exodeoxyribonuclease VII activity
azo1468	COG0811	peptide transport
azo1469	COG0848	biopolymer transport protein
azo1470	COG1663	tetraacyldisaccharide 4'-kinase activity
azo1471	COG2835	tetraacyldisaccharide 4'-kinase activity
azo1472	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
azo1473	COG0563	adenylate kinase activity
azo1475	COG0405	Gamma-glutamyltransferase
azo1476	COG5002	protein histidine kinase activity
azo1476	COG5001	Diguanylate cyclase
azo1477	COG2249	NAD(P)H dehydrogenase (quinone) activity
azo1479	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
azo1482	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
azo1482	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
azo1483	COG4085	toxin activity
azo1483	COG1525	nuclease
azo1483	COG0737	Belongs to the 5'-nucleotidase family
azo1486	COG2200	EAL domain
azo1486	COG2199	diguanylate cyclase activity
azo1486	COG3287	FIST C domain
azo1487	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
azo1489	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
azo1493	COG0501	Belongs to the peptidase M48B family
azo1494	COG1196	nuclear chromosome segregation
azo1497	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
azo1504	COG4585	Histidine kinase
azo1507	COG1032	radical SAM domain protein
azo1510	COG1136	(ABC) transporter
azo1513	COG2267	carboxylic ester hydrolase activity
azo1514	COG2308	Evidence 4 Homologs of previously reported genes of
azo1517	COG0501	Belongs to the peptidase M48B family
azo1518	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
azo1519	COG0166	Belongs to the GPI family
azo1521	COG0254	rRNA binding
azo1532	COG3012	SEC-C Motif Domain Protein
azo1533	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
azo1539	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
azo1540	COG0022	dehydrogenase e1 component
azo1540	COG0508	dehydrogenase complex catalyzes the overall conversion of
azo1542	COG2814	Major facilitator Superfamily
azo1547	COG0039	L-malate dehydrogenase activity
azo1548	COG2188	Transcriptional regulator
azo1551	COG1053	succinate dehydrogenase
azo1552	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
azo1553	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
azo1554	COG0372	Belongs to the citrate synthase family
azo1555	COG0567	Dehydrogenase, E1 component
azo1556	COG0508	dehydrogenase complex catalyzes the overall conversion of
azo1557	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
azo1559	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
azo1560	COG1199	ATP-dependent helicase activity
azo1561	COG1763	Mo-molybdopterin cofactor biosynthetic process
azo1562	COG0303	'Molybdopterin
azo1563	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
azo1564	COG0314	molybdopterin synthase activity
azo1566	COG0542	response to heat
azo1568	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
azo1570	COG3781	membrane
azo1571	COG0747	negative chemotaxis
azo1572	COG0601	transmembrane transport
azo1573	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
azo1574	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
azo1576	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
azo1577	COG2867	negative regulation of translational initiation
azo1578	COG2914	Belongs to the UPF0125 (RnfH) family
azo1581	COG0519	Catalyzes the synthesis of GMP from XMP
azo1581	COG0518	GMP synthase (glutamine-hydrolyzing) activity
azo1582	COG0583	DNA-binding transcription factor activity
azo1583	COG2249	NAD(P)H dehydrogenase (quinone) activity
azo1587	COG5002	protein histidine kinase activity
azo1588	COG0590	tRNA wobble adenosine to inosine editing
azo1589	COG1376	ErfK ybiS ycfS ynhG family protein
azo1594	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
azo1595	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
azo1598	COG0084	hydrolase, TatD family'
azo1602	COG1305	Transglutaminase-like
azo1603	COG2308	Evidence 4 Homologs of previously reported genes of
azo1603	COG2307	Protein conserved in bacteria
azo1605	COG1473	amidohydrolase
azo1606	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
azo1607	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
azo1609	COG1067	ATP-dependent peptidase activity
azo1611	COG0556	nucleotide-excision repair
azo1612	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
azo1613	COG1530	ribonuclease E activity
azo1614	COG0564	pseudouridine synthase activity
azo1615	COG0546	phosphoglycolate phosphatase activity
azo1617	COG0616	signal peptide processing
azo1618	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
azo1619	COG0424	maF-like protein
azo1620	COG1399	metal-binding, possibly nucleic acid-binding protein
azo1621	COG0333	Belongs to the bacterial ribosomal protein bL32 family
azo1622	COG0416	fatty acid biosynthetic process
azo1623	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
azo1624	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
azo1626	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
azo1627	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
azo1629	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
azo1634	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
azo1636	COG0583	DNA-binding transcription factor activity
azo1638	COG3181	Tripartite tricarboxylate transporter family receptor
azo1639	COG0481	GTPase activity
azo1640	COG0681	Belongs to the peptidase S26 family
azo1642	COG0571	ribonuclease III activity
azo1643	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
azo1644	COG1381	Involved in DNA repair and RecF pathway recombination
azo1645	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
azo1646	COG0736	holo-[acyl-carrier-protein] synthase activity
azo1647	COG1472	Belongs to the glycosyl hydrolase 3 family
azo1648	COG0322	excinuclease ABC activity
azo1649	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
azo1654	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
azo1656	COG0850	regulation of cytokinetic process
azo1657	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
azo1658	COG1393	Belongs to the ArsC family
azo1659	COG2183	response to ionizing radiation
azo1662	COG3852	Histidine kinase
azo1664	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
azo1667	COG4181	ATPase activity
azo1668	COG0560	Phosphoserine phosphatase
azo1669	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
azo1672	COG0598	Magnesium transport protein CorA
azo1673	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
azo1679	COG2078	PFAM AMMECR1 domain protein
azo1680	COG1355	regulation of microtubule-based process
azo1681	COG3174	membrane
azo1682	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
azo1683	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
azo1685	COG3228	Belongs to the MtfA family
azo1688	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
azo1689	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
azo1690	COG0248	Ppx GppA phosphatase
azo1691	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
azo1692	COG1127	ABC transporter
azo1693	COG3218	ABC-type transport auxiliary lipoprotein component
azo1693	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
azo1695	COG0318	PFAM AMP-dependent synthetase and ligase
azo1697	COG0084	hydrolase, TatD family'
azo1698	COG1309	transcriptional regulator
azo1702	COG1960	acyl-CoA dehydrogenase activity
azo1703	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
azo1705	COG2350	Protein conserved in bacteria
azo1706	COG2917	probably involved in intracellular septation
azo1708	COG2205	protein histidine kinase activity
azo1709	COG0745	RESPONSE REGULATOR receiver
azo1712	COG0456	acetyltransferase
azo1713	COG1573	uracil-dna glycosylase
azo1714	COG0477	Major facilitator Superfamily
azo1715	COG0583	DNA-binding transcription factor activity
azo1723	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
azo1725	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
azo1726	COG0366	Alpha amylase catalytic
azo1727	COG0366	Alpha amylase catalytic
azo1728	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
azo1732	COG1028	Short-chain dehydrogenase reductase Sdr
azo1739	COG1028	Short-chain dehydrogenase reductase Sdr
azo1740	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
azo1745	COG0189	ligase activity
azo1753	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
azo1757	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
azo1762	COG0628	permease
azo1763	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
azo1765	COG5487	UPF0391 membrane protein
azo1766	COG1252	NADH dehydrogenase
azo1771	COG1271	oxidase subunit
azo1772	COG1294	oxidase, subunit
azo1779	COG3023	N-Acetylmuramoyl-L-alanine amidase
azo1783	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
azo1786	COG0671	phosphoesterase, PA-phosphatase related
azo1788	COG0438	transferase activity, transferring glycosyl groups
azo1790	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
azo1796	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
azo1797	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
azo1798	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
azo1799	COG1640	4-alpha-glucanotransferase
azo1801	COG0297	glycogen (starch) synthase activity
azo1802	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
azo1805	COG2192	nodulation
azo1806	COG0859	PFAM glycosyl transferase family 9
azo1807	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
azo1809	COG0297	glycogen (starch) synthase activity
azo1811	COG2323	membrane
azo1812	COG2204	response regulator
azo1817	COG2205	protein histidine kinase activity
azo1818	COG1295	ribonuclease BN
azo1821	COG5265	(ABC) transporter
azo1823	COG1285	pathogenesis
azo1824	COG1058	Belongs to the CinA family
azo1824	COG1546	Belongs to the CinA family
azo1826	COG1090	epimerase
azo1828	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
azo1828	COG1017	nitric oxide dioxygenase activity
azo1830	COG4771	TonB-dependent receptor
azo1834	COG1252	NADH dehydrogenase
azo1841	COG0840	transmembrane signaling receptor activity
azo1856	COG4569	acetaldehyde dehydrogenase (acetylating) activity
azo1857	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
azo1862	COG0564	pseudouridine synthase activity
azo1863	COG0582	viral genome integration into host DNA
azo1870	COG0740	serine-type endopeptidase activity
azo1875	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
azo1876	COG1091	dTDP-4-dehydrorhamnose reductase activity
azo1879	COG3447	MASE1 domain protein
azo1879	COG5002	protein histidine kinase activity
azo1879	COG5001	Diguanylate cyclase
azo1882	COG4181	ATPase activity
azo1885	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
azo1886	COG2866	Carboxypeptidase
azo1887	COG3022	response to hydroperoxide
azo1889	COG0156	8-amino-7-oxononanoate synthase activity
azo1890	COG2267	carboxylic ester hydrolase activity
azo1891	COG2226	methyltransferase
azo1892	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
azo1893	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
azo1895	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
azo1896	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
azo1897	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
azo1898	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
azo1899	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
azo1903	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
azo1904	COG0575	Belongs to the CDS family
azo1905	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
azo1906	COG0233	cytoplasmic translational termination
azo1907	COG0528	UMP kinase activity
azo1908	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
azo1909	COG0052	Belongs to the universal ribosomal protein uS2 family
azo1910	COG0024	Methionine aminopeptidase
azo1911	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
azo1913	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
azo1914	COG2204	response regulator
azo1915	COG4191	Histidine kinase
azo1919	COG0579	oxidoreductase
azo1923	COG1804	L-carnitine dehydratase bile acid-inducible protein F
azo1924	COG1960	acyl-CoA dehydrogenase activity
azo1925	COG0583	DNA-binding transcription factor activity
azo1927	COG1024	Enoyl-CoA hydratase
azo1930	COG1960	acyl-CoA dehydrogenase activity
azo1931	COG1960	acyl-CoA dehydrogenase activity
azo1932	COG1024	Enoyl-CoA hydratase
azo1935	COG1846	Transcriptional regulator
azo1937	COG1028	Short-chain dehydrogenase reductase Sdr
azo1939	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
azo1940	COG2354	Protein conserved in bacteria
azo1943	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
azo1944	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
azo1946	COG0243	molybdopterin cofactor binding
azo1947	COG0437	4 iron, 4 sulfur cluster binding
azo1960	COG0543	2 iron, 2 sulfur cluster binding
azo1960	COG0633	Ferredoxin
azo1962	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
azo1964	COG2207	Transcriptional regulator
azo1966	COG0346	lactoylglutathione lyase activity
azo1969	COG1802	Transcriptional regulator
azo1971	COG1063	alcohol dehydrogenase
azo1972	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
azo1973	COG4569	acetaldehyde dehydrogenase (acetylating) activity
azo1974	COG3971	2-oxopent-4-enoate hydratase activity
azo1975	COG3384	dioxygenase
azo1976	COG0596	Alpha beta hydrolase
azo1976	COG0508	dehydrogenase complex catalyzes the overall conversion of
azo1978	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
azo1984	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
azo1985	COG0318	PFAM AMP-dependent synthetase and ligase
azo1988	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
azo1989	COG1028	Short-chain dehydrogenase reductase Sdr
azo1992	COG0411	ABC transporter
azo1994	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
azo2000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
azo2001	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
azo2003	COG1196	nuclear chromosome segregation
azo2004	COG0436	Aminotransferase
azo2005	COG2171	N-acyltransferase activity
azo2007	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
azo2009	COG0784	Response regulator, receiver
azo2011	COG0633	Ferredoxin
azo2012	COG0443	Heat shock 70 kDa protein
azo2013	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
azo2015	COG0822	iron-sulfur transferase activity
azo2016	COG1104	cysteine desulfurase activity
azo2017	COG1104	cysteine desulfurase activity
azo2019	COG1045	serine acetyltransferase
azo2023	COG2161	toxin-antitoxin pair type II binding
azo2024	COG4115	mRNA cleavage
azo2031	COG4372	Transposase
azo2047	COG2003	Belongs to the UPF0758 family
azo2048	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
azo2050	COG5433	transposase activity
azo2052	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
azo2054	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
azo2055	COG0328	RNA-DNA hybrid ribonuclease activity
azo2056	COG2226	methyltransferase
azo2057	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
azo2059	COG4251	negative regulation of phosphorylation
azo2059	COG3706	GGDEF domain
azo2059	COG2203	Gaf domain
azo2059	COG5001	Diguanylate cyclase
azo2060	COG0741	lytic transglycosylase activity
azo2060	COG1388	LysM domain
azo2062	COG1047	Peptidyl-prolyl cis-trans
azo2063	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
azo2064	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
azo2066	COG0534	Mate efflux family protein
azo2067	COG1393	Belongs to the ArsC family
azo2069	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
azo2070	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
azo2071	COG0740	serine-type endopeptidase activity
azo2072	COG0544	peptidyl-prolyl cis-trans isomerase activity
azo2073	COG2766	serine protein kinase
azo2074	COG2718	Belongs to the UPF0229 family
azo2075	COG2719	SpoVR family
azo2076	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
azo2076	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
azo2082	COG0436	Aminotransferase
azo2089	COG4968	Prepilin-type N-terminal cleavage methylation domain
azo2090	COG4796	Type ii and iii secretion system protein
azo2096	COG1459	type II secretion system
azo2097	COG2165	general secretion pathway protein
azo2098	COG1196	nuclear chromosome segregation
azo2098	COG0741	lytic transglycosylase activity
azo2098	COG0739	heme binding
azo2102	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
azo2103	COG1185	polyribonucleotide nucleotidyltransferase activity
azo2104	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
azo2105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
azo2106	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
azo2107	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
azo2108	COG2251	uridine kinase activity
azo2108	COG0195	Participates in both transcription termination and antitermination
azo2109	COG0779	Required for maturation of 30S ribosomal subunits
azo2110	COG1187	pseudouridine synthase activity
azo2111	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
azo2112	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
azo2113	COG1994	Peptidase M50
azo2114	COG0009	L-threonylcarbamoyladenylate synthase
azo2115	COG0613	PHP domain protein
azo2119	COG1012	belongs to the aldehyde dehydrogenase family
azo2120	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
azo2121	COG1278	Cold shock
azo2126	COG4681	YaeQ
azo2128	COG3706	GGDEF domain
azo2130	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
azo2132	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
azo2133	COG0302	gtp cyclohydrolase
azo2135	COG0306	phosphate transporter
azo2137	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
azo2141	COG0791	NLP P60 protein
azo2143	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
azo2144	COG0148	phosphopyruvate hydratase activity
azo2145	COG2877	3-deoxy-8-phosphooctulonate synthase activity
azo2146	COG0504	CTP synthase activity
azo2149	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
azo2150	COG0824	Thioesterase
azo2158	COG0047	phosphoribosylformylglycinamidine synthase activity
azo2158	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
azo2159	COG0671	phosphoesterase, PA-phosphatase related
azo2161	COG0463	Glycosyl transferase, family 2
azo2166	COG0739	heme binding
azo2168	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
azo2170	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
azo2171	COG0840	transmembrane signaling receptor activity
azo2172	COG0183	Belongs to the thiolase family
azo2173	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
azo2174	COG0494	nUDIX hydrolase
azo2180	COG4968	Prepilin-type N-terminal cleavage methylation domain
azo2183	COG1666	GTP binding
azo2184	COG3123	guanosine phosphorylase activity
azo2186	COG0137	argininosuccinate synthase activity
azo2187	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
azo2188	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
azo2190	COG0268	Binds directly to 16S ribosomal RNA
azo2195	COG2081	HI0933 family
azo2197	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
azo2198	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
azo2199	COG0840	transmembrane signaling receptor activity
azo2203	COG0791	NLP P60 protein
azo2205	COG1840	ABC-type Fe3 transport system, periplasmic component
azo2206	COG1178	ABC-type Fe3 transport system permease component
azo2207	COG3842	ATPase activity
azo2208	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
azo2209	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
azo2210	COG0167	dihydroorotate dehydrogenase activity
azo2214	COG1129	ABC transporter
azo2217	COG4772	TonB-dependent receptor
azo2219	COG0310	cobalt ion transport
azo2220	COG0310	cobalt ion transport
azo2222	COG1122	ATPase activity
azo2223	COG0402	S-adenosylhomocysteine deaminase activity
azo2224	COG1671	Belongs to the UPF0178 family
azo2231	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
azo2236	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
azo2237	COG0438	transferase activity, transferring glycosyl groups
azo2240	COG0489	protein tyrosine kinase activity
azo2246	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
azo2249	COG1573	uracil-dna glycosylase
azo2250	COG1012	belongs to the aldehyde dehydrogenase family
azo2253	COG2409	Drug exporters of the RND superfamily
azo2258	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
azo2259	COG2259	Doxx family
azo2265	COG0765	amino acid transport
azo2266	COG1126	abc transporter atp-binding protein
azo2272	COG3158	transport of potassium into the cell
azo2274	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
azo2275	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
azo2276	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
azo2279	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
azo2283	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
azo2284	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
azo2288	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
azo2290	COG0121	glutamine amidotransferase
azo2292	COG2169	Transcriptional regulator
azo2292	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
azo2296	COG2154	pterin-4-alpha-carbinolamine dehydratase
azo2299	COG1960	acyl-CoA dehydrogenase activity
azo2301	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
azo2307	COG1196	nuclear chromosome segregation
azo2310	COG0366	Alpha amylase catalytic
azo2313	COG0837	glucose binding
azo2316	COG1132	(ABC) transporter
azo2322	COG0297	glycogen (starch) synthase activity
azo2323	COG0438	transferase activity, transferring glycosyl groups
azo2324	COG0726	polysaccharide deacetylase
azo2327	COG0583	DNA-binding transcription factor activity
azo2328	COG3829	transcription factor binding
azo2334	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
azo2336	COG1538	Outer membrane efflux protein
azo2338	COG0793	Belongs to the peptidase S41A family
azo2343	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
azo2347	COG4771	TonB-dependent receptor
azo2353	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
azo2354	COG0798	PFAM Bile acid sodium symporter
azo2357	COG0154	amidase activity
azo2359	COG1942	4-Oxalocrotonate Tautomerase
azo2360	COG0583	DNA-binding transcription factor activity
azo2362	COG2205	protein histidine kinase activity
azo2363	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
azo2365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
azo2366	COG0459	protein refolding
azo2371	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
azo2373	COG1595	DNA-templated transcription, initiation
azo2374	COG3712	iron ion homeostasis
azo2375	COG4774	siderophore transport
azo2375	COG1629	transport
azo2380	COG0463	Glycosyl transferase, family 2
azo2391	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
azo2392	COG1116	anion transmembrane transporter activity
azo2393	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
azo2399	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
azo2402	COG0784	Response regulator, receiver
azo2402	COG2205	protein histidine kinase activity
azo2402	COG5002	protein histidine kinase activity
azo2403	COG4251	negative regulation of phosphorylation
azo2403	COG5001	Diguanylate cyclase
azo2403	COG3706	GGDEF domain
azo2403	COG2203	Gaf domain
azo2405	COG1764	response to oxidative stress
azo2407	COG1522	sequence-specific DNA binding
azo2408	COG3706	GGDEF domain
azo2409	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
azo2410	COG2176	DNA-directed DNA polymerase activity
azo2410	COG5002	protein histidine kinase activity
azo2411	COG0745	RESPONSE REGULATOR receiver
azo2412	COG5002	protein histidine kinase activity
azo2414	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
azo2418	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
azo2422	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
azo2424	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
azo2425	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
azo2425	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
azo2426	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
azo2431	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
azo2432	COG4569	acetaldehyde dehydrogenase (acetylating) activity
azo2433	COG1028	Short-chain dehydrogenase reductase Sdr
azo2437	COG1802	Transcriptional regulator
azo2450	COG2205	protein histidine kinase activity
azo2450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
azo2456	COG2202	Pas domain
azo2456	COG2205	protein histidine kinase activity
azo2457	COG2205	protein histidine kinase activity
azo2468	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
azo2474	COG0028	Belongs to the TPP enzyme family
azo2475	COG0583	DNA-binding transcription factor activity
azo2482	COG0784	Response regulator, receiver
azo2482	COG5002	protein histidine kinase activity
azo2482	COG2205	protein histidine kinase activity
azo2484	COG3437	response regulator, receiver
azo2489	COG0490	domain, Protein
azo2489	COG0471	metal ion transport
azo2490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
azo2494	COG1960	acyl-CoA dehydrogenase activity
azo2497	COG0183	Belongs to the thiolase family
azo2498	COG1024	Enoyl-CoA hydratase
azo2499	COG0318	PFAM AMP-dependent synthetase and ligase
azo2502	COG0411	ABC transporter
azo2504	COG1309	transcriptional regulator
azo2505	COG1309	transcriptional regulator
azo2524	COG0583	DNA-binding transcription factor activity
azo2527	COG2124	cytochrome p450
azo2528	COG0633	Ferredoxin
azo2531	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
azo2535	COG0667	Aldo Keto reductase
azo2542	COG2159	amidohydrolase
azo2543	COG2814	Major facilitator Superfamily
azo2545	COG2814	Major facilitator Superfamily
azo2547	COG0840	transmembrane signaling receptor activity
azo2549	COG0617	tRNA 3'-terminal CCA addition
azo2562	COG1858	cytochrome C peroxidase
azo2567	COG0583	DNA-binding transcription factor activity
azo2568	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
azo2576	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
azo2577	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
azo2578	COG0735	belongs to the Fur family
azo2579	COG0497	DNA recombination
azo2580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
azo2581	COG1420	regulation of RNA biosynthetic process
azo2582	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
azo2583	COG1950	PFAM Membrane protein of
azo2585	COG2815	serine threonine protein kinase
azo2585	COG0515	serine threonine protein kinase
azo2587	COG0402	S-adenosylhomocysteine deaminase activity
azo2589	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
azo2594	COG1858	cytochrome C peroxidase
azo2595	COG1858	cytochrome C peroxidase
azo2600	COG0583	DNA-binding transcription factor activity
azo2602	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
azo2603	COG1278	Cold shock
azo2607	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
azo2608	COG0235	Class ii aldolase
azo2612	COG5002	protein histidine kinase activity
azo2612	COG5001	Diguanylate cyclase
azo2612	COG3447	MASE1 domain protein
azo2617	COG0546	phosphoglycolate phosphatase activity
azo2618	COG0789	Transcriptional regulator
azo2622	COG0745	RESPONSE REGULATOR receiver
azo2622	COG3706	GGDEF domain
azo2630	COG1429	ligase activity, forming nitrogen-metal bonds
azo2633	COG4106	trans-aconitate 2-methyltransferase activity
azo2636	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
azo2637	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
azo2638	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
azo2647	COG0412	Dienelactone hydrolase
azo2649	COG3706	GGDEF domain
azo2649	COG0745	RESPONSE REGULATOR receiver
azo2653	COG0306	phosphate transporter
azo2656	COG1742	UPF0060 membrane protein
azo2660	COG1881	PFAM PEBP family protein
azo2663	COG0450	alkyl hydroperoxide reductase
azo2668	COG1902	pentaerythritol trinitrate reductase activity
azo2669	COG3258	Cytochrome c
azo2671	COG4566	intracellular signal transduction
azo2672	COG4191	Histidine kinase
azo2675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
azo2676	COG4106	trans-aconitate 2-methyltransferase activity
azo2678	COG1621	beta-fructofuranosidase activity
azo2684	COG0582	viral genome integration into host DNA
azo2688	COG3045	CreA protein
azo2691	COG3706	GGDEF domain
azo2692	COG3706	GGDEF domain
azo2698	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
azo2701	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
azo2706	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
azo2710	COG2257	FlhB HrpN YscU SpaS Family
azo2711	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
azo2713	COG1677	Flagellar hook-basal body complex protein FliE
azo2715	COG3852	Histidine kinase
azo2716	COG1766	The M ring may be actively involved in energy transduction
azo2717	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
azo2719	COG1157	protein secretion by the type III secretion system
azo2723	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
azo2724	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
azo2725	COG3190	flagellar
azo2726	COG1338	Plays a role in the flagellum-specific transport system
azo2727	COG1987	bacterial-type flagellum assembly
azo2731	COG1256	bacterial-type flagellum assembly
azo2732	COG3951	Flagellar rod assembly protein muramidase FlgJ
azo2732	COG1705	Flagellar rod assembly protein muramidase FlgJ
azo2733	COG1706	bacterial-type flagellum-dependent cell motility
azo2734	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
azo2735	COG4786	Flagellar basal body rod
azo2736	COG4787	bacterial-type flagellum-dependent cell motility
azo2737	COG1749	Flagellar hook protein flgE
azo2739	COG1558	bacterial-type flagellum-dependent cell motility
azo2740	COG1815	bacterial-type flagellum-dependent cell motility
azo2745	COG0745	RESPONSE REGULATOR receiver
azo2746	COG2205	protein histidine kinase activity
azo2750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
azo2751	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
azo2755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
azo2756	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
azo2757	COG0739	heme binding
azo2758	COG0316	Belongs to the HesB IscA family
azo2759	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
azo2760	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
azo2762	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
azo2764	COG0494	nUDIX hydrolase
azo2765	COG0442	prolyl-tRNA aminoacylation
azo2766	COG0741	lytic transglycosylase activity
azo2768	COG2205	protein histidine kinase activity
azo2770	COG2204	response regulator
azo2772	COG0482	sulfurtransferase activity
azo2780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
azo2781	COG2096	Adenosyltransferase
azo2786	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
azo2788	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
azo2790	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
azo2791	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
azo2792	COG0521	Mo-molybdopterin cofactor biosynthetic process
azo2793	COG3028	Belongs to the UPF0307 family
azo2794	COG0312	modulator of DNA gyrase
azo2795	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
azo2796	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
azo2799	COG2205	protein histidine kinase activity
azo2800	COG0745	RESPONSE REGULATOR receiver
azo2801	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
azo2802	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
azo2803	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
azo2803	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
azo2804	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
azo2806	COG0793	Belongs to the peptidase S41A family
azo2808	COG0588	phosphoglycerate mutase activity
azo2809	COG0640	Transcriptional regulator
azo2810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
azo2812	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
azo2814	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
azo2815	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
azo2816	COG1040	competence protein
azo2817	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
azo2818	COG2226	methyltransferase
azo2822	COG0218	Necessary for normal cell division and for the maintenance of normal septation
azo2824	COG2833	Protein of unknown function (DUF455)
azo2825	COG0303	'Molybdopterin
azo2826	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
azo2827	COG0704	Plays a role in the regulation of phosphate uptake
azo2828	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
azo2830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
azo2830	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
azo2832	COG1385	rRNA (uridine-N3-)-methyltransferase activity
azo2833	COG0483	inositol monophosphate 1-phosphatase activity
azo2836	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
azo2837	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
azo2839	COG0126	phosphoglycerate kinase activity
azo2842	COG0469	pyruvate kinase activity
azo2846	COG3284	Transcriptional regulator
azo2849	COG0745	RESPONSE REGULATOR receiver
azo2849	COG3706	GGDEF domain
azo2850	COG0477	Major facilitator Superfamily
azo2854	COG3220	belongs to the UPF0276 family
azo2856	COG2259	Doxx family
azo2857	COG1595	DNA-templated transcription, initiation
azo2860	COG2304	oxidoreductase activity
azo2862	COG0714	Associated with various cellular activities
azo2863	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
azo2864	COG2304	oxidoreductase activity
azo2867	COG0583	DNA-binding transcription factor activity
azo2868	COG3384	dioxygenase
azo2869	COG3038	cytochrome b561
azo2871	COG2353	YceI-like domain
azo2873	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
azo2877	COG0339	signal peptide processing
azo2878	COG1393	Belongs to the ArsC family
azo2879	COG0004	ammonium transporteR
azo2882	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
azo2884	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
azo2885	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
azo2886	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
azo2887	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
azo2890	COG0006	proline dipeptidase activity
azo2891	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
azo2893	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
azo2894	COG0138	bifunctional purine biosynthesis protein purh
azo2895	COG0151	Belongs to the GarS family
azo2896	COG0408	coproporphyrinogen oxidase activity
azo2898	COG0228	four-way junction DNA binding
azo2899	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
azo2900	COG0336	Belongs to the RNA methyltransferase TrmD family
azo2901	COG0335	large ribosomal subunit rRNA binding
azo2903	COG0795	lipopolysaccharide-transporting ATPase activity
azo2904	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
azo2907	COG0525	valine-tRNA ligase activity
azo2909	COG0842	Transport permease protein
azo2910	COG0842	Transport permease protein
azo2910	COG1129	ABC transporter
azo2911	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
azo2919	COG0425	Belongs to the sulfur carrier protein TusA family
azo2920	COG4783	chaperone-mediated protein folding
azo2921	COG0315	cyclic pyranopterin monophosphate synthase activity
azo2923	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
azo2929	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
azo2930	COG2414	aldehyde ferredoxin oxidoreductase
azo2932	COG3284	Transcriptional regulator
azo2936	COG3038	cytochrome b561
azo2937	COG4654	Cytochrome c, class I
azo2939	COG1012	belongs to the aldehyde dehydrogenase family
azo2940	COG3284	Transcriptional regulator
azo2945	COG5002	protein histidine kinase activity
azo2950	COG2132	Multicopper oxidase
azo2954	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
azo2955	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
azo2962	COG1595	DNA-templated transcription, initiation
azo2965	COG1741	Belongs to the pirin family
azo2966	COG2259	Doxx family
azo2967	COG0583	DNA-binding transcription factor activity
azo2968	COG0655	NAD(P)H dehydrogenase (quinone) activity
azo2979	COG3851	Histidine kinase
azo2981	COG0840	transmembrane signaling receptor activity
azo2983	COG5433	transposase activity
azo2986	COG4106	trans-aconitate 2-methyltransferase activity
azo2989	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
azo2990	COG1335	isochorismatase
azo2992	COG0583	DNA-binding transcription factor activity
azo2997	COG4774	siderophore transport
azo2999	COG3108	Peptidase M15
azo3000	COG2989	Protein conserved in bacteria
azo3003	COG0583	DNA-binding transcription factor activity
azo3011	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
azo3013	COG0069	glutamate synthase activity
azo3015	COG0004	ammonium transporteR
azo3021	COG1012	belongs to the aldehyde dehydrogenase family
azo3023	COG4772	TonB-dependent receptor
azo3025	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
azo3038	COG3383	formate dehydrogenase (NAD+) activity
azo3040	COG1250	3-hydroxyacyl-CoA dehydrogenase
azo3041	COG1773	rubredoxin
azo3042	COG3321	synthase
azo3042	COG0604	alcohol dehydrogenase
azo3042	COG1028	Short-chain dehydrogenase reductase Sdr
azo3043	COG1024	Enoyl-CoA hydratase
azo3047	COG0411	ABC transporter
azo3055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
azo3066	COG0318	PFAM AMP-dependent synthetase and ligase
azo3070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
azo3081	COG1960	acyl-CoA dehydrogenase activity
azo3083	COG3094	Invasion gene expression up-regulator, SirB
azo3088	COG2010	Cytochrome c
azo3091	COG0569	domain protein
azo3092	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
azo3093	COG0745	RESPONSE REGULATOR receiver
azo3094	COG2205	protein histidine kinase activity
azo3099	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
azo3101	COG1959	2 iron, 2 sulfur cluster binding
azo3102	COG2239	Acts as a magnesium transporter
azo3103	COG3245	cytochrome
azo3113	COG4263	nitrous-oxide reductase activity
azo3115	COG0527	aspartate kinase activity
azo3118	COG0720	synthase
azo3120	COG3264	Mechanosensitive ion channel
azo3120	COG1511	domain protein
azo3121	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
azo3122	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
azo3122	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
azo3124	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
azo3126	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
azo3128	COG0864	Transcriptional regulator
azo3130	COG1793	dna ligase
azo3131	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
azo3134	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
azo3136	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
azo3137	COG0628	permease
azo3138	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
azo3139	COG0560	Phosphoserine phosphatase
azo3140	COG0617	tRNA 3'-terminal CCA addition
azo3143	COG1428	Deoxynucleoside kinase
azo3144	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
azo3145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
azo3146	COG0516	GMP reductase activity
azo3146	COG0517	IMP dehydrogenase activity
azo3147	COG0308	aminopeptidase N
azo3154	COG0028	Belongs to the TPP enzyme family
azo3155	COG0440	acetolactate synthase activity
azo3156	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
azo3157	COG1183	phosphatidylcholine synthase activity
azo3159	COG2205	protein histidine kinase activity
azo3159	COG2198	Histidine kinase
azo3159	COG0784	Response regulator, receiver
azo3161	COG3642	lipopolysaccharide core region biosynthetic process
azo3162	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
azo3165	COG1295	ribonuclease BN
azo3167	COG0261	This protein binds to 23S rRNA in the presence of protein L20
azo3168	COG0211	Belongs to the bacterial ribosomal protein bL27 family
azo3169	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
azo3170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
azo3173	COG3320	Male sterility
azo3173	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
azo3174	COG0220	tRNA (guanine-N7-)-methyltransferase activity
azo3176	COG4591	ABC-type transport system involved in lipoprotein release permease component
azo3177	COG0577	efflux transmembrane transporter activity
azo3177	COG1136	(ABC) transporter
azo3179	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
azo3181	COG0604	alcohol dehydrogenase
azo3183	COG1704	LemA family
azo3188	COG1196	nuclear chromosome segregation
azo3188	COG0741	lytic transglycosylase activity
azo3188	COG0739	heme binding
azo3191	COG2204	response regulator
azo3193	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
azo3194	COG2030	dehydratase
azo3197	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
azo3199	COG1982	Orn Lys Arg decarboxylase major
azo3200	COG0717	Belongs to the dCTP deaminase family
azo3201	COG0489	protein tyrosine kinase activity
azo3202	COG2885	chlorophyll binding
azo3202	COG3047	cAMP biosynthetic process
azo3203	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
azo3203	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
azo3204	COG0659	secondary active sulfate transmembrane transporter activity
azo3205	COG1254	Belongs to the acylphosphatase family
azo3206	COG1368	sulfuric ester hydrolase activity
azo3211	COG0281	malic enzyme
azo3211	COG0280	phosphate acetyltransferase
azo3212	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
azo3213	COG0210	DNA helicase
azo3215	COG0495	leucyl-tRNA aminoacylation
azo3217	COG1466	dna polymerase III delta subunit
azo3218	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
azo3219	COG4974	Belongs to the 'phage' integrase family
azo3220	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
azo3223	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
azo3224	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
azo3225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
azo3227	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
azo3232	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
azo3239	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
azo3240	COG2204	response regulator
azo3243	COG0071	Belongs to the small heat shock protein (HSP20) family
azo3244	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
azo3246	COG0318	PFAM AMP-dependent synthetase and ligase
azo3255	COG2755	lipolytic protein G-D-S-L family
azo3255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
azo3256	COG2244	polysaccharide biosynthetic process
azo3257	COG5039	Polysaccharide pyruvyl transferase
azo3259	COG1215	transferase activity, transferring glycosyl groups
azo3261	COG0297	glycogen (starch) synthase activity
azo3262	COG0438	transferase activity, transferring glycosyl groups
azo3268	COG0297	glycogen (starch) synthase activity
azo3271	COG0367	asparagine synthase
azo3273	COG0367	asparagine synthase
azo3274	COG0438	transferase activity, transferring glycosyl groups
azo3279	COG3267	Type II secretory pathway component ExeA
azo3279	COG3409	Peptidoglycan-binding domain 1 protein
azo3281	COG0489	protein tyrosine kinase activity
azo3286	COG1136	(ABC) transporter
azo3286	COG0577	efflux transmembrane transporter activity
azo3288	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
azo3289	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
azo3292	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
azo3294	COG0109	protoheme IX farnesyltransferase activity
azo3295	COG1612	heme a metabolic process
azo3301	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
azo3303	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
azo3305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
azo3306	COG1283	sodium-dependent phosphate transmembrane transporter activity
azo3311	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
azo3317	COG0604	alcohol dehydrogenase
azo3320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
azo3322	COG0134	indole-3-glycerol-phosphate synthase activity
azo3323	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
azo3326	COG0546	phosphoglycolate phosphatase activity
azo3328	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
azo3329	COG1234	tRNA 3'-trailer cleavage
azo3331	COG0631	protein serine/threonine phosphatase activity
azo3332	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
azo3333	COG0045	succinate-CoA ligase (ADP-forming) activity
azo3336	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
azo3338	COG0805	protein transport
azo3339	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
azo3340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
azo3342	COG0140	phosphoribosyl-ATP diphosphatase activity
azo3343	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
azo3344	COG0107	imidazoleglycerol-phosphate synthase activity
azo3345	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
azo3346	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
azo3347	COG0131	Imidazoleglycerol-phosphate dehydratase
azo3348	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
azo3349	COG0741	lytic transglycosylase activity
azo3351	COG1131	(ABC) transporter
azo3359	COG0436	Aminotransferase
azo3360	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
azo3362	COG2084	Dehydrogenase
azo3363	COG2084	Dehydrogenase
azo3364	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
azo3368	COG3411	Ferredoxin
azo3370	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
azo3372	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
azo3378	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
azo3380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
azo3383	COG4251	negative regulation of phosphorylation
azo3385	COG0629	single-stranded DNA binding
azo3386	COG2814	Major facilitator Superfamily
azo3389	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
azo3390	COG0203	ribosomal protein L17
azo3391	COG0202	RNA polymerase activity
azo3392	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
azo3393	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
azo3394	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
azo3395	COG0257	Belongs to the bacterial ribosomal protein bL36 family
azo3396	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
azo3397	COG0201	protein transport
azo3398	COG0200	Binds to the 23S rRNA
azo3399	COG1841	ribosomal large subunit assembly
azo3400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
azo3401	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
azo3402	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
azo3403	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
azo3404	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
azo3405	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
azo3406	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
azo3407	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
azo3408	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
azo3409	COG0255	Belongs to the universal ribosomal protein uL29 family
azo3410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
azo3411	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
azo3412	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
azo3413	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
azo3414	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
azo3415	COG0089	rRNA binding
azo3416	COG0088	Forms part of the polypeptide exit tunnel
azo3417	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
azo3418	COG0051	transcription antitermination factor activity, RNA binding
azo3419	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
azo3420	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
azo3421	COG0049	tRNA binding
azo3422	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
azo3423	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
azo3424	COG0085	RNA polymerase activity
azo3425	COG0222	ribosome binding
azo3426	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
azo3427	COG0081	regulation of translation
azo3428	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
azo3430	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
azo3431	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
azo3432	COG0277	FAD linked oxidase domain protein
azo3436	COG2197	response regulator
azo3438	COG2198	Histidine kinase
azo3438	COG2205	protein histidine kinase activity
azo3438	COG0784	Response regulator, receiver
azo3440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
azo3445	COG0559	Belongs to the binding-protein-dependent transport system permease family
azo3446	COG0411	ABC transporter
azo3447	COG1022	Amp-dependent synthetase and ligase
azo3449	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
azo3450	COG0352	thiamine-phosphate diphosphorylase activity
azo3456	COG0840	transmembrane signaling receptor activity
azo3458	COG0415	Belongs to the DNA photolyase family
azo3459	COG1678	Uncharacterized ACR, COG1678
azo3460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
azo3461	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
azo3462	COG0540	Belongs to the ATCase OTCase family
azo3464	COG1872	DUF167
azo3465	COG0762	integral membrane protein
azo3470	COG3501	Rhs element vgr protein
azo3475	COG3290	protein histidine kinase activity
azo3475	COG0840	transmembrane signaling receptor activity
azo3476	COG0840	transmembrane signaling receptor activity
azo3481	COG0437	4 iron, 4 sulfur cluster binding
azo3482	COG0243	molybdopterin cofactor binding
azo3482	COG3383	formate dehydrogenase (NAD+) activity
azo3489	COG0746	molybdenum cofactor guanylyltransferase activity
azo3491	COG1763	Mo-molybdopterin cofactor biosynthetic process
azo3492	COG3852	Histidine kinase
azo3497	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
azo3498	COG5002	protein histidine kinase activity
azo3500	COG4654	Cytochrome c, class I
azo3501	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
azo3502	COG0830	nickel cation binding
azo3503	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
azo3504	COG0804	urea catabolic process
azo3505	COG0832	Belongs to the urease beta subunit family
azo3507	COG0831	urea catabolic process
azo3508	COG0829	nickel cation binding
azo3509	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
azo3509	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
azo3510	COG1368	sulfuric ester hydrolase activity
azo3512	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
azo3513	COG1116	anion transmembrane transporter activity
azo3514	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
azo3515	COG1733	regulation of RNA biosynthetic process
azo3517	COG1492	cobalamin metabolic process
azo3522	COG0513	Belongs to the DEAD box helicase family
azo3523	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
azo3524	COG0778	Nitroreductase
azo3527	COG5002	protein histidine kinase activity
azo3527	COG5001	Diguanylate cyclase
azo3532	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
azo3540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
azo3541	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
azo3542	COG0625	glutathione transferase activity
azo3544	COG0427	acetyl-CoA hydrolase
azo3546	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
azo3549	COG0688	phosphatidylethanolamine metabolic process
azo3550	COG1797	cobyrinic acid a,c-diamide synthase activity
azo3551	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
azo3551	COG1648	precorrin-2 dehydrogenase activity
azo3553	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
azo3554	COG4139	cobalamin transport
azo3555	COG4206	TonB-dependent receptor
azo3558	COG0501	Belongs to the peptidase M48B family
azo3559	COG4269	membrane
azo3560	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
azo3561	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
azo3563	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
azo3563	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
azo3564	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
azo3565	COG0859	PFAM glycosyl transferase family 9
azo3567	COG0438	transferase activity, transferring glycosyl groups
azo3572	COG1132	(ABC) transporter
azo3578	COG0438	transferase activity, transferring glycosyl groups
azo3579	COG2192	nodulation
azo3580	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
azo3580	COG2755	lipolytic protein G-D-S-L family
azo3582	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
azo3586	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
azo3595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
azo3599	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
azo3604	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
azo3607	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
azo3608	COG0799	negative regulation of ribosome biogenesis
azo3609	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
azo3610	COG0242	peptide deformylase activity
azo3611	COG0424	maF-like protein
azo3612	COG1530	ribonuclease E activity
azo3615	COG0745	RESPONSE REGULATOR receiver
azo3616	COG2205	protein histidine kinase activity
azo3618	COG0583	DNA-binding transcription factor activity
azo3621	COG2818	Glycosylase
azo3623	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
azo3624	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
azo3626	COG0443	Heat shock 70 kDa protein
azo3627	COG0741	lytic transglycosylase activity
azo3629	COG0583	DNA-binding transcription factor activity
azo3630	COG2814	Major facilitator Superfamily
azo3632	COG1132	(ABC) transporter
azo3636	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
azo3637	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
azo3642	COG0070	glutamate synthase
azo3642	COG0069	glutamate synthase activity
azo3642	COG0067	glutamate synthase
azo3643	COG0232	Belongs to the dGTPase family. Type 2 subfamily
azo3644	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
azo3645	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
azo3652	COG1965	Belongs to the frataxin family
azo3658	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
azo3659	COG0284	orotidine-5'-phosphate decarboxylase activity
azo3661	COG0243	molybdopterin cofactor binding
azo3663	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
azo3664	COG0708	Exodeoxyribonuclease III
azo3667	COG4575	ribosome binding
azo3672	COG0745	RESPONSE REGULATOR receiver
azo3673	COG0642	Histidine kinase
azo3674	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
azo3676	COG0625	glutathione transferase activity
azo3677	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
azo3689	COG0812	UDP-N-acetylmuramate dehydrogenase activity
azo3691	COG0840	transmembrane signaling receptor activity
azo3695	COG0180	Tryptophanyl-tRNA synthetase
azo3699	COG3876	Protein conserved in bacteria
azo3700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
azo3702	COG2226	methyltransferase
azo3703	COG2020	methyltransferase activity
azo3705	COG1917	Cupin 2, conserved barrel domain protein
azo3705	COG2169	Transcriptional regulator
azo3706	COG4106	trans-aconitate 2-methyltransferase activity
azo3709	COG0456	acetyltransferase
azo3711	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
azo3712	COG2816	NAD+ diphosphatase activity
azo3720	COG3547	Transposase (IS116 IS110 IS902 family)
azo3733	COG0411	ABC transporter
azo3735	COG2814	Major facilitator Superfamily
azo3739	COG0347	Belongs to the P(II) protein family
azo3740	COG0004	ammonium transporteR
azo3741	COG3047	cAMP biosynthetic process
azo3742	COG0788	formyltetrahydrofolate deformylase activity
azo3745	COG0488	(ABC) transporter
azo3750	COG1335	isochorismatase
azo3753	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
azo3753	COG0506	proline dehydrogenase activity
azo3753	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
azo3755	COG0189	ligase activity
azo3759	COG2703	oxygen carrier activity
azo3767	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
azo3768	COG0753	catalase activity
azo3769	COG0402	S-adenosylhomocysteine deaminase activity
azo3770	COG1652	LysM domain
azo3774	COG0515	serine threonine protein kinase
azo3774	COG2815	serine threonine protein kinase
azo3777	COG3706	GGDEF domain
azo3779	COG0488	(ABC) transporter
azo3780	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
azo3780	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
azo3781	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
azo3782	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
azo3786	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
azo3787	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
azo3795	COG1773	rubredoxin
azo3799	COG0375	protein maturation
azo3801	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
azo3803	COG0409	Hydrogenase expression formation protein
azo3804	COG0309	Hydrogenase expression formation protein (HypE)
azo3805	COG2204	response regulator
azo3809	COG5002	protein histidine kinase activity
azo3809	COG5001	Diguanylate cyclase
azo3809	COG3447	MASE1 domain protein
azo3810	COG4191	Histidine kinase
azo3811	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
azo3812	COG1194	a g-specific adenine glycosylase
azo3820	COG0559	Belongs to the binding-protein-dependent transport system permease family
azo3822	COG1970	mechanosensitive ion channel activity
azo3823	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
azo3826	COG3842	ATPase activity
azo3828	COG1349	DNA-binding transcription factor activity
azo3830	COG4302	ethanolamine ammonia-lyase activity
azo3841	COG2005	Transcriptional regulator
azo3841	COG3585	molybdate ion transport
azo3842	COG3842	ATPase activity
azo3845	COG4208	sulfate ABC transporter
azo3848	COG2982	Protein involved in outer membrane biogenesis
azo3850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
azo3851	COG1074	ATP-dependent DNA helicase activity
azo3852	COG4206	TonB-dependent receptor
azo3854	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
azo3855	COG1785	Belongs to the alkaline phosphatase family
azo3857	COG1024	Enoyl-CoA hydratase
azo3857	COG1250	3-hydroxyacyl-CoA dehydrogenase
azo3858	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
azo3859	COG0583	DNA-binding transcription factor activity
azo3860	COG0473	3-isopropylmalate dehydrogenase activity
azo3861	COG3530	Putative quorum-sensing-regulated virulence factor
azo3862	COG2095	MarC family integral membrane protein
azo3867	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
azo3868	COG0022	dehydrogenase e1 component
azo3871	COG0095	Lipoate-protein ligase
azo3875	COG3284	Transcriptional regulator
azo3876	COG3501	Rhs element vgr protein
azo3885	COG0631	protein serine/threonine phosphatase activity
azo3908	COG2815	serine threonine protein kinase
azo3908	COG0515	serine threonine protein kinase
azo3911	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
azo3914	COG1028	Short-chain dehydrogenase reductase Sdr
azo3915	COG0475	glutathione-regulated potassium exporter activity
azo3916	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
azo3924	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
azo3925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
azo3927	COG4235	cytochrome complex assembly
azo3928	COG3088	subunit of a heme lyase
azo3929	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
azo3931	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
azo3935	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
azo3936	COG4133	protoheme IX ABC transporter activity
azo3938	COG3005	denitrification pathway
azo3939	COG3043	anaerobic respiration
azo3940	COG0348	domain, Protein
azo3941	COG0437	4 iron, 4 sulfur cluster binding
azo3942	COG0243	molybdopterin cofactor binding
azo3944	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
azo3944	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
azo3945	COG2205	protein histidine kinase activity
azo3945	COG0784	Response regulator, receiver
azo3945	COG5002	protein histidine kinase activity
azo3946	COG2205	protein histidine kinase activity
azo3946	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
azo3947	COG4999	Histidine kinase
azo3947	COG3437	response regulator, receiver
azo3947	COG3850	Histidine kinase
azo3947	COG2205	protein histidine kinase activity
azo3948	COG2176	DNA-directed DNA polymerase activity
azo3948	COG5002	protein histidine kinase activity
azo3949	COG2226	methyltransferase
azo3951	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
azo3952	COG1758	RNA polymerase activity
azo3953	COG0194	GDP metabolic process
azo3957	COG0587	DNA-directed DNA polymerase activity
azo3959	COG0789	Transcriptional regulator
azo3960	COG1561	YicC-like family, N-terminal region
azo3961	COG3266	domain, Protein
azo3961	COG0515	serine threonine protein kinase
azo3962	COG0631	protein serine/threonine phosphatase activity
azo3963	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
azo3964	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
azo3965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
azo3967	COG0616	signal peptide processing
azo3968	COG0220	tRNA (guanine-N7-)-methyltransferase activity
azo3969	COG2022	thiamine diphosphate biosynthetic process
azo3971	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
azo3972	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
azo3972	COG2813	Specifically methylates the guanine in position
azo3975	COG2223	nitrite transmembrane transporter activity
azo3977	COG0288	reversible hydration of carbon dioxide
azo3978	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
azo3979	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
azo3980	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
azo3981	COG0569	domain protein
azo3982	COG2204	response regulator
azo3983	COG5000	phosphorelay sensor kinase activity
azo3986	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
azo3987	COG0730	response to heat
azo3988	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
azo3989	COG0706	membrane insertase activity
azo3990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
azo3991	COG0594	ribonuclease P activity
azo3992	COG0230	Belongs to the bacterial ribosomal protein bL34 family