locus-tag	class	description
CDA09_00005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CDA09_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CDA09_00060	COG3177	Filamentation induced by cAMP protein fic
CDA09_00065	COG2336	PFAM SpoVT AbrB
CDA09_00085	COG5001	Diguanylate cyclase
CDA09_00085	COG4251	negative regulation of phosphorylation
CDA09_00085	COG2203	Gaf domain
CDA09_00085	COG3706	GGDEF domain
CDA09_00095	COG0655	NAD(P)H dehydrogenase (quinone) activity
CDA09_00120	COG1116	anion transmembrane transporter activity
CDA09_00125	COG0686	Belongs to the AlaDH PNT family
CDA09_00140	COG3706	GGDEF domain
CDA09_00145	COG0583	DNA-binding transcription factor activity
CDA09_00150	COG1960	acyl-CoA dehydrogenase activity
CDA09_00155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDA09_00165	COG2974	May be involved in recombination
CDA09_00175	COG1187	pseudouridine synthase activity
CDA09_00185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CDA09_00195	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CDA09_00225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDA09_00230	COG4206	TonB-dependent receptor
CDA09_00240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDA09_00250	COG2922	Belongs to the Smg family
CDA09_00255	COG0758	DNA mediated transformation
CDA09_00265	COG0242	peptide deformylase activity
CDA09_00270	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CDA09_00275	COG0501	Belongs to the peptidase M48B family
CDA09_00280	COG3852	Histidine kinase
CDA09_00285	COG2204	response regulator
CDA09_00290	COG1763	Mo-molybdopterin cofactor biosynthetic process
CDA09_00310	COG0746	molybdenum cofactor guanylyltransferase activity
CDA09_00315	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CDA09_00345	COG3383	formate dehydrogenase (NAD+) activity
CDA09_00350	COG0437	4 iron, 4 sulfur cluster binding
CDA09_00405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDA09_00410	COG0765	amino acid transport
CDA09_00415	COG0765	amino acid transport
CDA09_00420	COG1126	abc transporter atp-binding protein
CDA09_00425	COG2824	Alkylphosphonate utilization operon protein PhnA
CDA09_00440	COG0445	tRNA wobble uridine modification
CDA09_00445	COG0357	Ribosomal RNA small subunit methyltransferase G
CDA09_00450	COG1192	Involved in chromosome partitioning
CDA09_00455	COG1475	DNA binding
CDA09_00465	COG0356	it plays a direct role in the translocation of protons across the membrane
CDA09_00475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CDA09_00480	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CDA09_00485	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CDA09_00490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CDA09_00495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CDA09_00500	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CDA09_00515	COG2226	methyltransferase
CDA09_00525	COG0745	RESPONSE REGULATOR receiver
CDA09_00545	COG0121	glutamine amidotransferase
CDA09_00550	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDA09_00560	COG0154	amidase activity
CDA09_00565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDA09_00570	COG1077	Cell shape determining protein MreB Mrl
CDA09_00585	COG0768	penicillin binding
CDA09_00590	COG0772	Belongs to the SEDS family
CDA09_00600	COG1686	Belongs to the peptidase S11 family
CDA09_00610	COG2921	Belongs to the UPF0250 family
CDA09_00615	COG0321	lipoyl(octanoyl) transferase activity
CDA09_00620	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CDA09_00625	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CDA09_00640	COG0840	transmembrane signaling receptor activity
CDA09_00660	COG4566	intracellular signal transduction
CDA09_00725	COG1902	pentaerythritol trinitrate reductase activity
CDA09_00730	COG0514	ATP-dependent DNA helicase (RecQ)
CDA09_00755	COG0411	ABC transporter
CDA09_00770	COG0683	leucine binding
CDA09_00790	COG0500	methyltransferase
CDA09_00810	COG2271	Major facilitator Superfamily
CDA09_00825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDA09_00840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CDA09_00855	COG3179	chitinase
CDA09_00865	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CDA09_00870	COG3842	ATPase activity
CDA09_00875	COG1176	ABC-type spermidine putrescine transport system, permease component I
CDA09_00880	COG1177	transmembrane transport
CDA09_00885	COG1132	(ABC) transporter
CDA09_00930	COG2205	protein histidine kinase activity
CDA09_00935	COG1131	(ABC) transporter
CDA09_00950	COG3134	Outer membrane lipoprotein
CDA09_00965	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CDA09_00970	COG1074	ATP-dependent DNA helicase activity
CDA09_00975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CDA09_00980	COG4191	Histidine kinase
CDA09_00985	COG2204	response regulator
CDA09_01000	COG0739	heme binding
CDA09_01000	COG1196	nuclear chromosome segregation
CDA09_01000	COG0741	lytic transglycosylase activity
CDA09_01080	COG2165	general secretion pathway protein
CDA09_01095	COG1278	Cold shock
CDA09_01105	COG0330	HflC and HflK could
CDA09_01135	COG0477	Major facilitator Superfamily
CDA09_01145	COG1305	Transglutaminase-like
CDA09_01150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDA09_01160	COG3045	CreA protein
CDA09_01170	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CDA09_01175	COG0484	heat shock protein binding
CDA09_01200	COG0194	GDP metabolic process
CDA09_01205	COG1758	RNA polymerase activity
CDA09_01210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDA09_01215	COG0523	cobalamin synthesis protein
CDA09_01220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDA09_01245	COG3850	Histidine kinase
CDA09_01250	COG2197	response regulator
CDA09_01265	COG0243	molybdopterin cofactor binding
CDA09_01270	COG0437	4 iron, 4 sulfur cluster binding
CDA09_01275	COG0348	domain, Protein
CDA09_01280	COG3043	anaerobic respiration
CDA09_01285	COG3005	denitrification pathway
CDA09_01290	COG4133	protoheme IX ABC transporter activity
CDA09_01295	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CDA09_01305	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CDA09_01310	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CDA09_01320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDA09_01325	COG3088	subunit of a heme lyase
CDA09_01330	COG3088	subunit of a heme lyase
CDA09_01330	COG4235	cytochrome complex assembly
CDA09_01345	COG2010	Cytochrome c
CDA09_01355	COG2204	response regulator
CDA09_01360	COG4191	Histidine kinase
CDA09_01375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDA09_01385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CDA09_01470	COG3245	cytochrome
CDA09_01475	COG2010	Cytochrome c
CDA09_01515	COG1215	transferase activity, transferring glycosyl groups
CDA09_01545	COG3706	GGDEF domain
CDA09_01555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CDA09_01575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CDA09_01580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDA09_01585	COG1522	sequence-specific DNA binding
CDA09_01635	COG0835	chemotaxis
CDA09_01640	COG0840	transmembrane signaling receptor activity
CDA09_01640	COG3290	protein histidine kinase activity
CDA09_01650	COG2201	protein-glutamate methylesterase activity
CDA09_01655	COG4191	Histidine kinase
CDA09_01670	COG1012	belongs to the aldehyde dehydrogenase family
CDA09_01675	COG1024	Enoyl-CoA hydratase
CDA09_01680	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDA09_01685	COG2050	protein possibly involved in aromatic compounds catabolism
CDA09_01695	COG3396	Phenylacetate-CoA oxygenase
CDA09_01700	COG3460	Phenylacetate-CoA oxygenase
CDA09_01705	COG3396	Phenylacetate-CoA oxygenase
CDA09_01710	COG2151	metal-sulfur cluster biosynthetic enzyme
CDA09_01715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDA09_01735	COG0411	ABC transporter
CDA09_01755	COG0583	DNA-binding transcription factor activity
CDA09_01765	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CDA09_01790	COG0513	Belongs to the DEAD box helicase family
CDA09_01795	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CDA09_01800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CDA09_01815	COG4232	protein-disulfide reductase activity
CDA09_01835	COG0745	RESPONSE REGULATOR receiver
CDA09_01840	COG2205	protein histidine kinase activity
CDA09_01865	COG3279	Response regulator of the LytR AlgR family
CDA09_01880	COG2203	Gaf domain
CDA09_01880	COG3706	GGDEF domain
CDA09_01880	COG4251	negative regulation of phosphorylation
CDA09_01880	COG5001	Diguanylate cyclase
CDA09_01895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDA09_01930	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CDA09_01935	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CDA09_01945	COG1845	cytochrome c oxidase, subunit III
CDA09_01960	COG0861	Integral membrane protein TerC family
CDA09_01990	COG0625	glutathione transferase activity
CDA09_01995	COG2945	thiolester hydrolase activity
CDA09_01995	COG0596	Alpha beta hydrolase
CDA09_02045	COG1331	Highly conserved protein containing a thioredoxin domain
CDA09_02080	COG0581	inorganic phosphate transmembrane transporter activity
CDA09_02085	COG0573	inorganic phosphate transmembrane transporter activity
CDA09_02090	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CDA09_02100	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CDA09_02120	COG0346	lactoylglutathione lyase activity
CDA09_02145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CDA09_02150	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CDA09_02155	COG0018	arginyl-trna synthetase
CDA09_02170	COG0300	oxidoreductase activity
CDA09_02175	COG2902	Dehydrogenase
CDA09_02185	COG0826	peptidase U32
CDA09_02230	COG3158	transport of potassium into the cell
CDA09_02235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CDA09_02245	COG3243	poly(R)-hydroxyalkanoic acid synthase
CDA09_02250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDA09_02255	COG0789	Transcriptional regulator
CDA09_02260	COG0288	reversible hydration of carbon dioxide
CDA09_02265	COG0183	Belongs to the thiolase family
CDA09_02270	COG1960	acyl-CoA dehydrogenase activity
CDA09_02275	COG1024	Enoyl-CoA hydratase
CDA09_02295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDA09_02300	COG1660	Displays ATPase and GTPase activities
CDA09_02320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CDA09_02335	COG1301	dicarboxylic acid transport
CDA09_02345	COG0217	transcriptional regulatory protein
CDA09_02355	COG0433	COG0433 Predicted ATPase
CDA09_02380	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CDA09_02390	COG1278	Cold shock
CDA09_02395	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CDA09_02405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CDA09_02415	COG1560	Kdo2-lipid A biosynthetic process
CDA09_02420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CDA09_02430	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CDA09_02440	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CDA09_02450	COG2255	four-way junction helicase activity
CDA09_02455	COG0632	four-way junction helicase activity
CDA09_02465	COG1530	ribonuclease E activity
CDA09_02470	COG0424	maF-like protein
CDA09_02475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CDA09_02480	COG0799	negative regulation of ribosome biogenesis
CDA09_02485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CDA09_02500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CDA09_02520	COG2192	nodulation
CDA09_02525	COG0726	polysaccharide deacetylase
CDA09_02535	COG0438	transferase activity, transferring glycosyl groups
CDA09_02550	COG0438	transferase activity, transferring glycosyl groups
CDA09_02555	COG0438	transferase activity, transferring glycosyl groups
CDA09_02570	COG0367	asparagine synthase
CDA09_02585	COG1132	(ABC) transporter
CDA09_02595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDA09_02600	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CDA09_02600	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CDA09_02605	COG2890	protein-(glutamine-N5) methyltransferase activity
CDA09_02610	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CDA09_02615	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CDA09_02635	COG4139	cobalamin transport
CDA09_02640	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CDA09_02650	COG1648	precorrin-2 dehydrogenase activity
CDA09_02650	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CDA09_02660	COG2818	Glycosylase
CDA09_02665	COG0583	DNA-binding transcription factor activity
CDA09_02685	COG1139	Iron-sulfur cluster binding protein
CDA09_02690	COG0247	lactate metabolic process
CDA09_02695	COG0697	spore germination
CDA09_02705	COG0583	DNA-binding transcription factor activity
CDA09_02710	COG1032	radical SAM domain protein
CDA09_02715	COG3023	N-Acetylmuramoyl-L-alanine amidase
CDA09_02720	COG0741	lytic transglycosylase activity
CDA09_02725	COG0436	Aminotransferase
CDA09_02735	COG0280	phosphate acetyltransferase
CDA09_02735	COG0281	malic enzyme
CDA09_02745	COG1686	Belongs to the peptidase S11 family
CDA09_02755	COG1187	pseudouridine synthase activity
CDA09_02770	COG0577	efflux transmembrane transporter activity
CDA09_02770	COG1136	(ABC) transporter
CDA09_02780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDA09_02785	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDA09_02790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CDA09_02810	COG1643	Atp-dependent helicase
CDA09_02815	COG0360	Binds together with S18 to 16S ribosomal RNA
CDA09_02820	COG2965	DNA replication, synthesis of RNA primer
CDA09_02825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CDA09_02830	COG0359	binds to the 23S rRNA
CDA09_02835	COG0305	Participates in initiation and elongation during chromosome replication
CDA09_02895	COG1704	LemA family
CDA09_02905	COG0604	alcohol dehydrogenase
CDA09_02910	COG0745	RESPONSE REGULATOR receiver
CDA09_02915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDA09_02925	COG0741	lytic transglycosylase activity
CDA09_02930	COG1459	type II secretion system
CDA09_02975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CDA09_02980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CDA09_02985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CDA09_02990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CDA09_03000	COG0277	FAD linked oxidase domain protein
CDA09_03005	COG0277	FAD linked oxidase domain protein
CDA09_03010	COG0247	lactate metabolic process
CDA09_03015	COG0631	protein serine/threonine phosphatase activity
CDA09_03020	COG0598	Magnesium transport protein CorA
CDA09_03025	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CDA09_03030	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
CDA09_03035	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
CDA09_03045	COG3300	MHYT domain
CDA09_03045	COG5001	Diguanylate cyclase
CDA09_03050	COG0513	Belongs to the DEAD box helicase family
CDA09_03055	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CDA09_03070	COG0584	glycerophosphoryl diester phosphodiesterase
CDA09_03075	COG0142	geranyltranstransferase activity
CDA09_03090	COG2353	YceI-like domain
CDA09_03095	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CDA09_03115	COG4654	Cytochrome c, class I
CDA09_03120	COG0583	DNA-binding transcription factor activity
CDA09_03135	COG1473	amidohydrolase
CDA09_03140	COG0583	DNA-binding transcription factor activity
CDA09_03150	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDA09_03155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDA09_03170	COG0583	DNA-binding transcription factor activity
CDA09_03175	COG0509	glycine decarboxylation via glycine cleavage system
CDA09_03185	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CDA09_03190	COG1113	amino acid transport
CDA09_03195	COG1760	l-serine dehydratase
CDA09_03200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CDA09_03205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CDA09_03220	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CDA09_03225	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CDA09_03265	COG0492	ferredoxin-NADP+ reductase activity
CDA09_03280	COG2030	dehydratase
CDA09_03285	COG1469	GTP cyclohydrolase I activity
CDA09_03290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CDA09_03295	COG0142	geranyltranstransferase activity
CDA09_03300	COG1722	exodeoxyribonuclease VII activity
CDA09_03310	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CDA09_03315	COG1047	Peptidyl-prolyl cis-trans
CDA09_03320	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CDA09_03325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CDA09_03330	COG0196	riboflavin kinase activity
CDA09_03335	COG0860	N-Acetylmuramoyl-L-alanine amidase
CDA09_03340	COG0802	atpase or kinase
CDA09_03350	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CDA09_03365	COG0697	spore germination
CDA09_03370	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CDA09_03375	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CDA09_03385	COG0583	DNA-binding transcription factor activity
CDA09_03390	COG2205	protein histidine kinase activity
CDA09_03395	COG0745	RESPONSE REGULATOR receiver
CDA09_03410	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDA09_03415	COG0542	response to heat
CDA09_03420	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CDA09_03425	COG1278	Cold shock
CDA09_03430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CDA09_03435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CDA09_03440	COG2003	Belongs to the UPF0758 family
CDA09_03445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CDA09_03450	COG0756	dUTP diphosphatase activity
CDA09_03460	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDA09_03465	COG2863	cytochrome
CDA09_03480	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CDA09_03490	COG0538	isocitrate dehydrogenase activity
CDA09_03510	COG1346	cytolysis
CDA09_03520	COG4206	TonB-dependent receptor
CDA09_03535	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CDA09_03550	COG0583	DNA-binding transcription factor activity
CDA09_03565	COG2308	Evidence 4 Homologs of previously reported genes of
CDA09_03605	COG3501	Rhs element vgr protein
CDA09_03670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CDA09_03685	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CDA09_03690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CDA09_03695	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CDA09_03715	COG4974	Belongs to the 'phage' integrase family
CDA09_03725	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CDA09_03730	COG1466	dna polymerase III delta subunit
CDA09_03740	COG0495	leucyl-tRNA aminoacylation
CDA09_03750	COG0210	DNA helicase
CDA09_03755	COG1192	Involved in chromosome partitioning
CDA09_03760	COG0281	malic enzyme
CDA09_03760	COG0280	phosphate acetyltransferase
CDA09_03785	COG0450	alkyl hydroperoxide reductase
CDA09_03790	COG1254	Belongs to the acylphosphatase family
CDA09_03795	COG0659	secondary active sulfate transmembrane transporter activity
CDA09_03800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDA09_03800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDA09_03805	COG2885	chlorophyll binding
CDA09_03805	COG3047	cAMP biosynthetic process
CDA09_03810	COG0489	protein tyrosine kinase activity
CDA09_03815	COG0717	Belongs to the dCTP deaminase family
CDA09_03820	COG1982	Orn Lys Arg decarboxylase major
CDA09_03830	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CDA09_03865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDA09_03870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CDA09_03875	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CDA09_03885	COG0494	nUDIX hydrolase
CDA09_03890	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CDA09_03895	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CDA09_03900	COG0237	dephospho-CoA kinase activity
CDA09_03910	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CDA09_03915	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CDA09_03925	COG2204	response regulator
CDA09_03930	COG3852	Histidine kinase
CDA09_03955	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CDA09_03960	COG3568	Endonuclease Exonuclease Phosphatase
CDA09_03965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CDA09_03980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDA09_03990	COG0463	Glycosyl transferase, family 2
CDA09_04005	COG0564	pseudouridine synthase activity
CDA09_04010	COG0012	GTP binding
CDA09_04015	COG0193	aminoacyl-tRNA hydrolase activity
CDA09_04020	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CDA09_04025	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CDA09_04035	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CDA09_04040	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CDA09_04050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CDA09_04055	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CDA09_04060	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDA09_04065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CDA09_04070	COG0742	ribosomal rna small subunit methyltransferase
CDA09_04080	COG0612	Peptidase, M16
CDA09_04090	COG2884	Cell division ATP-binding protein ftsE
CDA09_04095	COG2177	Part of the ABC transporter FtsEX involved in
CDA09_04105	COG0784	Response regulator, receiver
CDA09_04105	COG4191	Histidine kinase
CDA09_04115	COG1607	acyl-coa hydrolase
CDA09_04120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CDA09_04145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDA09_04150	COG1702	phosphate starvation-inducible protein PhoH
CDA09_04155	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CDA09_04160	COG4535	Mg2 and Co2 transporter CorC
CDA09_04165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CDA09_04170	COG0752	glycyl-tRNA synthetase alpha subunit
CDA09_04175	COG0751	glycine-tRNA ligase activity
CDA09_04180	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CDA09_04185	COG0204	Acyl-transferase
CDA09_04205	COG1024	Enoyl-CoA hydratase
CDA09_04230	COG1127	ABC transporter
CDA09_04235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CDA09_04240	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CDA09_04245	COG2853	Lipoprotein
CDA09_04260	COG1131	(ABC) transporter
CDA09_04265	COG0842	Transport permease protein
CDA09_04275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CDA09_04280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CDA09_04285	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CDA09_04290	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CDA09_04295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CDA09_04300	COG0131	Imidazoleglycerol-phosphate dehydratase
CDA09_04305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CDA09_04310	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CDA09_04315	COG0107	imidazoleglycerol-phosphate synthase activity
CDA09_04320	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CDA09_04325	COG0140	phosphoribosyl-ATP diphosphatase activity
CDA09_04335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CDA09_04340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CDA09_04345	COG0805	protein transport
CDA09_04350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDA09_04355	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CDA09_04370	COG0045	succinate-CoA ligase (ADP-forming) activity
CDA09_04375	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CDA09_04385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDA09_04395	COG0306	phosphate transporter
CDA09_04400	COG0105	UTP biosynthetic process
CDA09_04405	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CDA09_04415	COG1426	Protein conserved in bacteria
CDA09_04420	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CDA09_04425	COG0124	histidyl-tRNA synthetase
CDA09_04430	COG2976	Protein conserved in bacteria
CDA09_04435	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDA09_04440	COG1160	GTP binding
CDA09_04445	COG1923	regulation of RNA biosynthetic process
CDA09_04450	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CDA09_04455	COG0330	HflC and HflK could
CDA09_04460	COG0330	HflC and HflK could
CDA09_04470	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CDA09_04475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CDA09_04490	COG0557	exoribonuclease II activity
CDA09_04495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDA09_04500	COG3707	response regulator
CDA09_04515	COG0535	radical SAM domain protein
CDA09_04525	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CDA09_04530	COG0167	dihydroorotate dehydrogenase activity
CDA09_04535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDA09_04540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDA09_04545	COG1116	anion transmembrane transporter activity
CDA09_04555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDA09_04565	COG2223	nitrite transmembrane transporter activity
CDA09_04570	COG0515	serine threonine protein kinase
CDA09_04575	COG0243	molybdopterin cofactor binding
CDA09_04580	COG5001	Diguanylate cyclase
CDA09_04585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDA09_04600	COG1752	Esterase of the alpha-beta hydrolase superfamily
CDA09_04605	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CDA09_04610	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CDA09_04615	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CDA09_04620	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CDA09_04625	COG0723	plastoquinol--plastocyanin reductase activity
CDA09_04630	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CDA09_04635	COG2857	Cytochrome c1
CDA09_04640	COG0625	glutathione transferase activity
CDA09_04645	COG2969	positive regulation of protein catabolic process
CDA09_04650	COG0438	transferase activity, transferring glycosyl groups
CDA09_04655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDA09_04660	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CDA09_04670	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDA09_04670	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDA09_04670	COG0506	proline dehydrogenase activity
CDA09_04700	COG1448	Aminotransferase
CDA09_04705	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CDA09_04710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CDA09_04720	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_04745	COG0028	Belongs to the TPP enzyme family
CDA09_04755	COG0679	Auxin Efflux Carrier
CDA09_04770	COG1012	belongs to the aldehyde dehydrogenase family
CDA09_04800	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CDA09_04805	COG0459	protein refolding
CDA09_04815	COG0642	Histidine kinase
CDA09_04820	COG3162	membrane
CDA09_04920	COG0175	sulfate reduction
CDA09_04925	COG0730	response to heat
CDA09_04930	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CDA09_04935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CDA09_04940	COG2890	protein-(glutamine-N5) methyltransferase activity
CDA09_04945	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CDA09_04950	COG0515	serine threonine protein kinase
CDA09_04950	COG2815	serine threonine protein kinase
CDA09_04955	COG0165	Argininosuccinate lyase
CDA09_04965	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CDA09_04970	COG0181	hydroxymethylbilane synthase activity
CDA09_04980	COG2959	enzyme of heme biosynthesis
CDA09_04990	COG0408	coproporphyrinogen oxidase activity
CDA09_04995	COG0151	Belongs to the GarS family
CDA09_05005	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CDA09_05010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CDA09_05015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDA09_05020	COG0006	proline dipeptidase activity
CDA09_05035	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CDA09_05040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDA09_05045	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CDA09_05050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CDA09_05060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDA09_05080	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CDA09_05100	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CDA09_05110	COG2885	chlorophyll binding
CDA09_05115	COG5002	protein histidine kinase activity
CDA09_05115	COG5001	Diguanylate cyclase
CDA09_05125	COG3706	GGDEF domain
CDA09_05125	COG0745	RESPONSE REGULATOR receiver
CDA09_05135	COG0778	Nitroreductase
CDA09_05140	COG0469	pyruvate kinase activity
CDA09_05155	COG0126	phosphoglycerate kinase activity
CDA09_05160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CDA09_05165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CDA09_05170	COG3954	Phosphoribulokinase
CDA09_05175	COG0483	inositol monophosphate 1-phosphatase activity
CDA09_05180	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CDA09_05190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CDA09_05190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CDA09_05195	COG5001	Diguanylate cyclase
CDA09_05195	COG3300	MHYT domain
CDA09_05200	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CDA09_05205	COG0704	Plays a role in the regulation of phosphate uptake
CDA09_05210	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CDA09_05215	COG0303	'Molybdopterin
CDA09_05225	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CDA09_05240	COG2226	methyltransferase
CDA09_05245	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CDA09_05250	COG1040	competence protein
CDA09_05255	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CDA09_05260	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CDA09_05270	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CDA09_05280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CDA09_05285	COG0640	Transcriptional regulator
CDA09_05290	COG0588	phosphoglycerate mutase activity
CDA09_05300	COG0793	Belongs to the peptidase S41A family
CDA09_05310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDA09_05310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDA09_05315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CDA09_05320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CDA09_05325	COG0406	alpha-ribazole phosphatase activity
CDA09_05330	COG0312	modulator of DNA gyrase
CDA09_05335	COG3028	Belongs to the UPF0307 family
CDA09_05340	COG0521	Mo-molybdopterin cofactor biosynthetic process
CDA09_05345	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CDA09_05350	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CDA09_05365	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CDA09_05370	COG2096	Adenosyltransferase
CDA09_05375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CDA09_05420	COG0482	sulfurtransferase activity
CDA09_05440	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CDA09_05450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CDA09_05455	COG0312	modulator of DNA gyrase
CDA09_05465	COG2204	response regulator
CDA09_05475	COG2205	protein histidine kinase activity
CDA09_05490	COG0741	lytic transglycosylase activity
CDA09_05495	COG0442	prolyl-tRNA aminoacylation
CDA09_05500	COG0494	nUDIX hydrolase
CDA09_05510	COG1592	Rubrerythrin
CDA09_05515	COG0247	lactate metabolic process
CDA09_05530	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CDA09_05535	COG1765	OsmC-like protein
CDA09_05540	COG3033	Beta-eliminating lyase
CDA09_05545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CDA09_05550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CDA09_05555	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CDA09_05560	COG0316	Belongs to the HesB IscA family
CDA09_05570	COG0739	heme binding
CDA09_05575	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CDA09_05625	COG2423	ornithine cyclodeaminase activity
CDA09_05630	COG0583	DNA-binding transcription factor activity
CDA09_05650	COG1960	acyl-CoA dehydrogenase activity
CDA09_05655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CDA09_05665	COG0318	PFAM AMP-dependent synthetase and ligase
CDA09_05675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDA09_05680	COG0402	S-adenosylhomocysteine deaminase activity
CDA09_05690	COG0745	RESPONSE REGULATOR receiver
CDA09_05690	COG3706	GGDEF domain
CDA09_05705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CDA09_05710	COG1360	Flagellar Motor Protein
CDA09_05720	COG2201	protein-glutamate methylesterase activity
CDA09_05725	COG0835	chemotaxis
CDA09_05725	COG0784	Response regulator, receiver
CDA09_05730	COG0784	Response regulator, receiver
CDA09_05730	COG0835	chemotaxis
CDA09_05735	COG0745	RESPONSE REGULATOR receiver
CDA09_05740	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CDA09_05745	COG2198	Histidine kinase
CDA09_05745	COG0643	Histidine kinase
CDA09_05750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CDA09_05755	COG0564	pseudouridine synthase activity
CDA09_05760	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CDA09_05765	COG0583	DNA-binding transcription factor activity
CDA09_05770	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CDA09_05775	COG4208	sulfate ABC transporter
CDA09_05780	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CDA09_05855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDA09_05860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDA09_05865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDA09_05885	COG2814	Major facilitator Superfamily
CDA09_05925	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CDA09_05930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CDA09_05935	COG1570	exodeoxyribonuclease VII activity
CDA09_05940	COG0811	peptide transport
CDA09_05945	COG0848	biopolymer transport protein
CDA09_05950	COG1663	tetraacyldisaccharide 4'-kinase activity
CDA09_05955	COG2835	tetraacyldisaccharide 4'-kinase activity
CDA09_05960	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CDA09_05965	COG0563	adenylate kinase activity
CDA09_05970	COG0205	6-phosphofructokinase activity
CDA09_05990	COG0268	Binds directly to 16S ribosomal RNA
CDA09_06000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CDA09_06005	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CDA09_06010	COG0137	argininosuccinate synthase activity
CDA09_06020	COG3123	guanosine phosphorylase activity
CDA09_06025	COG1666	GTP binding
CDA09_06030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CDA09_06035	COG1127	ABC transporter
CDA09_06055	COG0335	large ribosomal subunit rRNA binding
CDA09_06060	COG0336	Belongs to the RNA methyltransferase TrmD family
CDA09_06065	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CDA09_06070	COG0228	four-way junction DNA binding
CDA09_06080	COG1295	ribonuclease BN
CDA09_06095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDA09_06110	COG1858	cytochrome C peroxidase
CDA09_06120	COG0745	RESPONSE REGULATOR receiver
CDA09_06125	COG2205	protein histidine kinase activity
CDA09_06130	COG1183	phosphatidylcholine synthase activity
CDA09_06135	COG0688	phosphatidylethanolamine metabolic process
CDA09_06140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CDA09_06150	COG0028	Belongs to the TPP enzyme family
CDA09_06175	COG0308	aminopeptidase N
CDA09_06185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CDA09_06190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CDA09_06195	COG1428	Deoxynucleoside kinase
CDA09_06210	COG0617	tRNA 3'-terminal CCA addition
CDA09_06220	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CDA09_06225	COG0628	permease
CDA09_06230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CDA09_06240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDA09_06250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CDA09_06265	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CDA09_06275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDA09_06285	COG0745	RESPONSE REGULATOR receiver
CDA09_06305	COG0745	RESPONSE REGULATOR receiver
CDA09_06310	COG2205	protein histidine kinase activity
CDA09_06315	COG2733	membrane
CDA09_06340	COG1785	Belongs to the alkaline phosphatase family
CDA09_06350	COG0655	NAD(P)H dehydrogenase (quinone) activity
CDA09_06355	COG0004	ammonium transporteR
CDA09_06360	COG0697	spore germination
CDA09_06365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CDA09_06370	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CDA09_06380	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDA09_06385	COG0438	transferase activity, transferring glycosyl groups
CDA09_06385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CDA09_06400	COG0651	ATP synthesis coupled electron transport
CDA09_06405	COG0650	Formate hydrogenlyase subunit 4
CDA09_06415	COG0651	ATP synthesis coupled electron transport
CDA09_06420	COG0649	NAD binding
CDA09_06425	COG3260	NADH ubiquinone oxidoreductase 20
CDA09_06430	COG2259	Doxx family
CDA09_06435	COG0469	pyruvate kinase activity
CDA09_06450	COG2084	Dehydrogenase
CDA09_06455	COG3622	Belongs to the hyi family
CDA09_06460	COG3960	tartronate-semialdehyde synthase activity
CDA09_06490	COG2201	protein-glutamate methylesterase activity
CDA09_06505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDA09_06515	COG4974	Belongs to the 'phage' integrase family
CDA09_06520	COG0517	IMP dehydrogenase activity
CDA09_06530	COG0583	DNA-binding transcription factor activity
CDA09_06540	COG3409	Peptidoglycan-binding domain 1 protein
CDA09_06540	COG3267	Type II secretory pathway component ExeA
CDA09_06570	COG1132	(ABC) transporter
CDA09_06575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDA09_06585	COG0765	amino acid transport
CDA09_06590	COG0765	amino acid transport
CDA09_06595	COG1126	abc transporter atp-binding protein
CDA09_06710	COG1815	bacterial-type flagellum-dependent cell motility
CDA09_06715	COG1558	bacterial-type flagellum-dependent cell motility
CDA09_06720	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CDA09_06725	COG1749	Flagellar hook protein flgE
CDA09_06730	COG4787	bacterial-type flagellum-dependent cell motility
CDA09_06735	COG4786	Flagellar basal body rod
CDA09_06740	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CDA09_06745	COG1706	bacterial-type flagellum-dependent cell motility
CDA09_06755	COG1256	bacterial-type flagellum assembly
CDA09_06775	COG1987	bacterial-type flagellum assembly
CDA09_06785	COG3190	flagellar
CDA09_06795	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CDA09_06815	COG1157	protein secretion by the type III secretion system
CDA09_06825	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CDA09_06830	COG1766	The M ring may be actively involved in energy transduction
CDA09_06835	COG3852	Histidine kinase
CDA09_06845	COG1677	Flagellar hook-basal body complex protein FliE
CDA09_06855	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CDA09_06860	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CDA09_06880	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CDA09_06885	COG1334	flagellar protein FlaG
CDA09_06895	COG3706	GGDEF domain
CDA09_06895	COG0745	RESPONSE REGULATOR receiver
CDA09_06900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDA09_06905	COG0508	dehydrogenase complex catalyzes the overall conversion of
CDA09_06910	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CDA09_06925	COG4566	intracellular signal transduction
CDA09_06945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CDA09_06950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CDA09_06955	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CDA09_06960	COG0009	L-threonylcarbamoyladenylate synthase
CDA09_06995	COG4691	Plasmid stability protein
CDA09_07025	COG2151	metal-sulfur cluster biosynthetic enzyme
CDA09_07035	COG2862	Uncharacterized protein family, UPF0114
CDA09_07040	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CDA09_07045	COG0024	Methionine aminopeptidase
CDA09_07050	COG0052	Belongs to the universal ribosomal protein uS2 family
CDA09_07055	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CDA09_07060	COG0528	UMP kinase activity
CDA09_07065	COG0233	cytoplasmic translational termination
CDA09_07070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CDA09_07075	COG0575	Belongs to the CDS family
CDA09_07080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CDA09_07100	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDA09_07105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CDA09_07110	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDA09_07115	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDA09_07120	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CDA09_07130	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDA09_07135	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CDA09_07140	COG2226	methyltransferase
CDA09_07145	COG2267	carboxylic ester hydrolase activity
CDA09_07150	COG0156	8-amino-7-oxononanoate synthase activity
CDA09_07160	COG3022	response to hydroperoxide
CDA09_07165	COG2866	Carboxypeptidase
CDA09_07170	COG0560	Phosphoserine phosphatase
CDA09_07175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CDA09_07180	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDA09_07185	COG1773	rubredoxin
CDA09_07215	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CDA09_07240	COG4263	nitrous-oxide reductase activity
CDA09_07250	COG2197	response regulator
CDA09_07255	COG3850	Histidine kinase
CDA09_07260	COG2181	nitrate reductase activity
CDA09_07265	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CDA09_07270	COG1140	nitrate reductase beta subunit
CDA09_07275	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CDA09_07315	COG2154	pterin-4-alpha-carbinolamine dehydratase
CDA09_07335	COG3706	GGDEF domain
CDA09_07340	COG0587	DNA-directed DNA polymerase activity
CDA09_07345	COG1671	Belongs to the UPF0178 family
CDA09_07355	COG0534	Mate efflux family protein
CDA09_07400	COG4447	cellulose binding
CDA09_07425	COG0604	alcohol dehydrogenase
CDA09_07425	COG3321	synthase
CDA09_07425	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_07430	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_07435	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_07460	COG1024	Enoyl-CoA hydratase
CDA09_07465	COG1881	PFAM PEBP family protein
CDA09_07595	COG1301	dicarboxylic acid transport
CDA09_07605	COG4191	Histidine kinase
CDA09_07660	COG2205	protein histidine kinase activity
CDA09_07665	COG0784	Response regulator, receiver
CDA09_07670	COG4585	Histidine kinase
CDA09_07675	COG2197	response regulator
CDA09_07685	COG0318	PFAM AMP-dependent synthetase and ligase
CDA09_07700	COG4191	Histidine kinase
CDA09_07710	COG2204	response regulator
CDA09_07715	COG1100	Small GTP-binding protein
CDA09_07720	COG4191	Histidine kinase
CDA09_07745	COG4566	intracellular signal transduction
CDA09_07770	COG4772	TonB-dependent receptor
CDA09_07790	COG0039	L-malate dehydrogenase activity
CDA09_07805	COG1403	HNH endonuclease
CDA09_07810	COG0386	Belongs to the glutathione peroxidase family
CDA09_07815	COG0625	glutathione transferase activity
CDA09_07830	COG3851	Histidine kinase
CDA09_07865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDA09_07870	COG4215	(ABC) transporter
CDA09_07895	COG4191	Histidine kinase
CDA09_07905	COG3158	transport of potassium into the cell
CDA09_07920	COG1999	signal sequence binding
CDA09_07935	COG3284	Transcriptional regulator
CDA09_07940	COG1012	belongs to the aldehyde dehydrogenase family
CDA09_07965	COG1131	(ABC) transporter
CDA09_08005	COG3284	Transcriptional regulator
CDA09_08015	COG2414	aldehyde ferredoxin oxidoreductase
CDA09_08020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDA09_08040	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDA09_08045	COG0583	DNA-binding transcription factor activity
CDA09_08050	COG0702	epimerase
CDA09_08055	COG3038	cytochrome b561
CDA09_08060	COG2353	YceI-like domain
CDA09_08125	COG0315	cyclic pyranopterin monophosphate synthase activity
CDA09_08130	COG4783	chaperone-mediated protein folding
CDA09_08135	COG0425	Belongs to the sulfur carrier protein TusA family
CDA09_08140	COG0525	valine-tRNA ligase activity
CDA09_08155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CDA09_08160	COG0795	lipopolysaccharide-transporting ATPase activity
CDA09_08180	COG1959	2 iron, 2 sulfur cluster binding
CDA09_08190	COG2814	Major facilitator Superfamily
CDA09_08195	COG0583	DNA-binding transcription factor activity
CDA09_08200	COG0564	pseudouridine synthase activity
CDA09_08245	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CDA09_08255	COG1192	Involved in chromosome partitioning
CDA09_08295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDA09_08315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDA09_08360	COG5554	nitrogen fixation
CDA09_08365	COG5554	nitrogen fixation
CDA09_08375	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CDA09_08390	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CDA09_08395	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
CDA09_08410	COG5420	small protein containing a coiled-coil domain
CDA09_08440	COG0583	DNA-binding transcription factor activity
CDA09_08445	COG1295	ribonuclease BN
CDA09_08450	COG0714	Associated with various cellular activities
CDA09_08455	COG2425	protein containing a von Willebrand factor type A (vWA) domain
CDA09_08480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDA09_08490	COG0683	leucine binding
CDA09_08500	COG0559	Belongs to the binding-protein-dependent transport system permease family
CDA09_08505	COG0411	ABC transporter
CDA09_08565	COG1176	ABC-type spermidine putrescine transport system, permease component I
CDA09_08575	COG3842	ATPase activity
CDA09_08610	COG1953	Uracil, thiamine, allantoin
CDA09_08630	COG0583	DNA-binding transcription factor activity
CDA09_08635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDA09_08650	COG0674	pyruvate-flavodoxin oxidoreductase activity
CDA09_08650	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CDA09_08655	COG1013	pyruvate-flavodoxin oxidoreductase activity
CDA09_08660	COG0179	Fumarylacetoacetate (FAA) hydrolase
CDA09_08675	COG2271	Major facilitator Superfamily
CDA09_08705	COG0513	Belongs to the DEAD box helicase family
CDA09_08710	COG1451	nucleotide metabolic process
CDA09_08715	COG0166	Belongs to the GPI family
CDA09_08740	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CDA09_08745	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CDA09_08755	COG0535	radical SAM domain protein
CDA09_08765	COG0435	Glutathione S-transferase
CDA09_08770	COG2259	Doxx family
CDA09_08775	COG0400	carboxylic ester hydrolase activity
CDA09_08785	COG1960	acyl-CoA dehydrogenase activity
CDA09_08790	COG0183	Belongs to the thiolase family
CDA09_08805	COG1902	pentaerythritol trinitrate reductase activity
CDA09_08820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDA09_08840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDA09_08845	COG0837	glucose binding
CDA09_08860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDA09_08900	COG2010	Cytochrome c
CDA09_08930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDA09_08940	COG5002	protein histidine kinase activity
CDA09_08945	COG0745	RESPONSE REGULATOR receiver
CDA09_08950	COG5002	protein histidine kinase activity
CDA09_08950	COG2176	DNA-directed DNA polymerase activity
CDA09_08955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CDA09_09000	COG1140	nitrate reductase beta subunit
CDA09_09005	COG0243	molybdopterin cofactor binding
CDA09_09045	COG0477	Major facilitator Superfamily
CDA09_09050	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_09070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDA09_09120	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CDA09_09145	COG2086	electron transfer activity
CDA09_09170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDA09_09180	COG1024	Enoyl-CoA hydratase
CDA09_09200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CDA09_09205	COG0318	PFAM AMP-dependent synthetase and ligase
CDA09_09210	COG2186	Transcriptional regulator
CDA09_09215	COG0318	PFAM AMP-dependent synthetase and ligase
CDA09_09220	COG1960	acyl-CoA dehydrogenase activity
CDA09_09225	COG1960	acyl-CoA dehydrogenase activity
CDA09_09235	COG2186	Transcriptional regulator
CDA09_09255	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_09270	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_09290	COG2197	response regulator
CDA09_09320	COG3436	PFAM IS66 Orf2 family protein
CDA09_09325	COG4372	Transposase
CDA09_09385	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_09395	COG1960	acyl-CoA dehydrogenase activity
CDA09_09410	COG1960	acyl-CoA dehydrogenase activity
CDA09_09460	COG2267	carboxylic ester hydrolase activity
CDA09_09470	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_09475	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_09485	COG0183	Belongs to the thiolase family
CDA09_09500	COG0318	PFAM AMP-dependent synthetase and ligase
CDA09_09505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDA09_09510	COG1960	acyl-CoA dehydrogenase activity
CDA09_09520	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDA09_09520	COG1024	Enoyl-CoA hydratase
CDA09_09525	COG0183	Belongs to the thiolase family
CDA09_09530	COG1309	transcriptional regulator
CDA09_09535	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CDA09_09560	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CDA09_09635	COG1024	Enoyl-CoA hydratase
CDA09_09640	COG2070	2-Nitropropane dioxygenase
CDA09_09645	COG1024	Enoyl-CoA hydratase
CDA09_09650	COG1960	acyl-CoA dehydrogenase activity
CDA09_09655	COG1960	acyl-CoA dehydrogenase activity
CDA09_09660	COG0183	Belongs to the thiolase family
CDA09_09665	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_09675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDA09_09695	COG1960	acyl-CoA dehydrogenase activity
CDA09_09710	COG2086	electron transfer activity
CDA09_09725	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_09735	COG1024	Enoyl-CoA hydratase
CDA09_09750	COG1902	pentaerythritol trinitrate reductase activity
CDA09_09750	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDA09_09755	COG1053	succinate dehydrogenase
CDA09_09770	COG3657	addiction module killer protein
CDA09_09775	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CDA09_09780	COG0477	Major facilitator Superfamily
CDA09_09785	COG1902	pentaerythritol trinitrate reductase activity
CDA09_09800	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_09810	COG3608	succinylglutamate desuccinylase aspartoacylase
CDA09_09810	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CDA09_09820	COG0488	(ABC) transporter
CDA09_09830	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CDA09_09850	COG1960	acyl-CoA dehydrogenase activity
CDA09_09855	COG1960	acyl-CoA dehydrogenase activity
CDA09_09865	COG1024	Enoyl-CoA hydratase
CDA09_09870	COG2852	Protein conserved in bacteria
CDA09_09885	COG0318	PFAM AMP-dependent synthetase and ligase
CDA09_09895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDA09_09900	COG2070	2-Nitropropane dioxygenase
CDA09_09925	COG3177	Filamentation induced by cAMP protein fic
CDA09_09935	COG1012	belongs to the aldehyde dehydrogenase family
CDA09_09940	COG2828	Protein conserved in bacteria
CDA09_09945	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDA09_09960	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CDA09_09965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDA09_09980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDA09_09985	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CDA09_10000	COG1024	Enoyl-CoA hydratase
CDA09_10015	COG2814	Major facilitator Superfamily
CDA09_10025	COG1902	pentaerythritol trinitrate reductase activity
CDA09_10025	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDA09_10030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDA09_10060	COG1024	Enoyl-CoA hydratase
CDA09_10075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDA09_10105	COG1960	acyl-CoA dehydrogenase activity
CDA09_10110	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CDA09_10125	COG0247	lactate metabolic process
CDA09_10125	COG2181	nitrate reductase activity
CDA09_10155	COG0745	RESPONSE REGULATOR receiver
CDA09_10160	COG5278	phosphoserine phosphatase activity
CDA09_10160	COG0840	transmembrane signaling receptor activity
CDA09_10170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CDA09_10175	COG0573	inorganic phosphate transmembrane transporter activity
CDA09_10180	COG0581	inorganic phosphate transmembrane transporter activity
CDA09_10185	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDA09_10235	COG4566	intracellular signal transduction
CDA09_10330	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CDA09_10335	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDA09_10395	COG1944	ATP diphosphatase activity
CDA09_10455	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CDA09_10460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDA09_10470	COG3851	Histidine kinase
CDA09_10475	COG2197	response regulator
CDA09_10480	COG3396	Phenylacetate-CoA oxygenase
CDA09_10485	COG3460	Phenylacetate-CoA oxygenase
CDA09_10490	COG3396	Phenylacetate-CoA oxygenase
CDA09_10495	COG2151	metal-sulfur cluster biosynthetic enzyme
CDA09_10500	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDA09_10515	COG0183	Belongs to the thiolase family
CDA09_10520	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CDA09_10535	COG0667	Aldo Keto reductase
CDA09_10545	COG0589	response to stress
CDA09_10575	COG0559	Belongs to the binding-protein-dependent transport system permease family
CDA09_10590	COG0410	ABC transporter
CDA09_10610	COG0463	Glycosyl transferase, family 2
CDA09_10625	COG2391	methyltransferase activity
CDA09_10665	COG1595	DNA-templated transcription, initiation
CDA09_10675	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CDA09_10690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CDA09_10710	COG0789	Transcriptional regulator
CDA09_10770	COG2226	methyltransferase
CDA09_10780	COG0573	inorganic phosphate transmembrane transporter activity
CDA09_10785	COG0573	inorganic phosphate transmembrane transporter activity
CDA09_10790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDA09_10800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDA09_10845	COG0745	RESPONSE REGULATOR receiver
CDA09_10860	COG0784	Response regulator, receiver
CDA09_10870	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CDA09_10875	COG5598	trimethylamine methyltransferase
CDA09_10900	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDA09_10900	COG1902	pentaerythritol trinitrate reductase activity
CDA09_10905	COG2181	nitrate reductase activity
CDA09_10905	COG0247	lactate metabolic process
CDA09_10910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CDA09_10925	COG2113	Glycine betaine
CDA09_10930	COG4175	Glycine betaine
CDA09_10945	COG4638	Rieske (2fe-2S)
CDA09_10965	COG2814	Major facilitator Superfamily
CDA09_10995	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CDA09_11010	COG1396	sequence-specific DNA binding
CDA09_11025	COG5598	trimethylamine methyltransferase
CDA09_11035	COG0583	DNA-binding transcription factor activity
CDA09_11040	COG4638	Rieske (2fe-2S)
CDA09_11050	COG4176	ABC-type proline glycine betaine transport system permease component
CDA09_11055	COG2113	Glycine betaine
CDA09_11065	COG4977	sequence-specific DNA binding
CDA09_11070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDA09_11075	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDA09_11080	COG1012	belongs to the aldehyde dehydrogenase family
CDA09_11085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDA09_11085	COG1017	nitric oxide dioxygenase activity
CDA09_11100	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CDA09_11110	COG5012	cobalamin binding
CDA09_11145	COG0477	Major facilitator Superfamily
CDA09_11150	COG0583	DNA-binding transcription factor activity
CDA09_11155	COG0583	DNA-binding transcription factor activity
CDA09_11160	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_11165	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_11175	COG0583	DNA-binding transcription factor activity
CDA09_11195	COG5012	cobalamin binding
CDA09_11200	COG0646	methionine synthase
CDA09_11200	COG1410	methionine synthase
CDA09_11215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CDA09_11220	COG1760	l-serine dehydratase
CDA09_11270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CDA09_11275	COG2011	ABC-type metal ion transport system permease component
CDA09_11285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CDA09_11305	COG0702	epimerase
CDA09_11315	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
CDA09_11320	COG0189	ligase activity
CDA09_11330	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
CDA09_11340	COG3284	Transcriptional regulator
CDA09_11350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CDA09_11390	COG1538	Outer membrane efflux protein
CDA09_11395	COG0745	RESPONSE REGULATOR receiver
CDA09_11400	COG2205	protein histidine kinase activity
CDA09_11415	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDA09_11440	COG0697	spore germination
CDA09_11470	COG2010	Cytochrome c
CDA09_11520	COG1229	Formylmethanofuran dehydrogenase subunit A
CDA09_11550	COG0019	diaminopimelate decarboxylase activity
CDA09_11555	COG0302	gtp cyclohydrolase
CDA09_11560	COG0583	DNA-binding transcription factor activity
CDA09_11570	COG4451	ribulose bisphosphate carboxylase, small
CDA09_11580	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CDA09_11585	COG3954	Phosphoribulokinase
CDA09_11590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CDA09_11595	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CDA09_11600	COG0126	phosphoglycerate kinase activity
CDA09_11605	COG0191	fructose-bisphosphate aldolase activity
CDA09_11655	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_11675	COG0798	PFAM Bile acid sodium symporter
CDA09_11680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CDA09_11690	COG0625	glutathione transferase activity
CDA09_11695	COG1063	alcohol dehydrogenase
CDA09_11725	COG1942	4-Oxalocrotonate Tautomerase
CDA09_11730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CDA09_11735	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CDA09_11745	COG1773	rubredoxin
CDA09_11750	COG1024	Enoyl-CoA hydratase
CDA09_11755	COG0318	PFAM AMP-dependent synthetase and ligase
CDA09_11765	COG1846	Transcriptional regulator
CDA09_11775	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CDA09_11780	COG1960	acyl-CoA dehydrogenase activity
CDA09_11795	COG1024	Enoyl-CoA hydratase
CDA09_11800	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDA09_11805	COG0183	Belongs to the thiolase family
CDA09_11835	COG1522	sequence-specific DNA binding
CDA09_11840	COG3108	Peptidase M15
CDA09_11845	COG2989	Protein conserved in bacteria
CDA09_11890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CDA09_11900	COG4172	Belongs to the ABC transporter superfamily
CDA09_11905	COG0741	lytic transglycosylase activity
CDA09_11905	COG1388	LysM domain
CDA09_11910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDA09_11920	COG0328	RNA-DNA hybrid ribonuclease activity
CDA09_11925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CDA09_11965	COG5001	Diguanylate cyclase
CDA09_11965	COG4251	negative regulation of phosphorylation
CDA09_11965	COG3706	GGDEF domain
CDA09_11965	COG2203	Gaf domain
CDA09_11970	COG0243	molybdopterin cofactor binding
CDA09_11980	COG1858	cytochrome C peroxidase
CDA09_11985	COG1858	cytochrome C peroxidase
CDA09_11990	COG2204	response regulator
CDA09_11995	COG3852	Histidine kinase
CDA09_12010	COG1858	cytochrome C peroxidase
CDA09_12020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CDA09_12025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CDA09_12030	COG0450	alkyl hydroperoxide reductase
CDA09_12055	COG2363	Small membrane protein
CDA09_12060	COG2814	Major facilitator Superfamily
CDA09_12070	COG0411	ABC transporter
CDA09_12095	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_12100	COG1024	Enoyl-CoA hydratase
CDA09_12165	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CDA09_12175	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDA09_12210	COG2133	pyrroloquinoline quinone binding
CDA09_12255	COG0410	ABC transporter
CDA09_12275	COG1966	Carbon starvation protein
CDA09_12280	COG2879	small protein
CDA09_12285	COG0523	cobalamin synthesis protein
CDA09_12300	COG2205	protein histidine kinase activity
CDA09_12300	COG0784	Response regulator, receiver
CDA09_12300	COG5002	protein histidine kinase activity
CDA09_12310	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CDA09_12315	COG0477	Major facilitator Superfamily
CDA09_12345	COG1012	belongs to the aldehyde dehydrogenase family
CDA09_12350	COG1253	flavin adenine dinucleotide binding
CDA09_12355	COG4681	YaeQ
CDA09_12365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CDA09_12370	COG0302	gtp cyclohydrolase
CDA09_12380	COG0306	phosphate transporter
CDA09_12390	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CDA09_12395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CDA09_12415	COG0791	NLP P60 protein
CDA09_12420	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CDA09_12425	COG0148	phosphopyruvate hydratase activity
CDA09_12430	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CDA09_12435	COG0504	CTP synthase activity
CDA09_12445	COG1335	isochorismatase
CDA09_12465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CDA09_12465	COG0047	phosphoribosylformylglycinamidine synthase activity
CDA09_12475	COG0463	Glycosyl transferase, family 2
CDA09_12485	COG0671	phosphoesterase, PA-phosphatase related
CDA09_12505	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDA09_12505	COG1902	pentaerythritol trinitrate reductase activity
CDA09_12525	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CDA09_12535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDA09_12555	COG1136	(ABC) transporter
CDA09_12565	COG1620	l-lactate permease
CDA09_12590	COG3047	cAMP biosynthetic process
CDA09_12610	COG1196	nuclear chromosome segregation
CDA09_12625	COG1473	amidohydrolase
CDA09_12635	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CDA09_12640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CDA09_12640	COG2169	Transcriptional regulator
CDA09_12645	COG3530	Putative quorum-sensing-regulated virulence factor
CDA09_12650	COG2195	Cleaves the N-terminal amino acid of tripeptides
CDA09_12665	COG1136	(ABC) transporter
CDA09_12665	COG0577	efflux transmembrane transporter activity
CDA09_12680	COG1309	transcriptional regulator
CDA09_12695	COG0477	Major facilitator Superfamily
CDA09_12700	COG1573	uracil-dna glycosylase
CDA09_12705	COG0456	acetyltransferase
CDA09_12710	COG1214	PFAM Peptidase M22, glycoprotease
CDA09_12720	COG0745	RESPONSE REGULATOR receiver
CDA09_12730	COG2917	probably involved in intracellular septation
CDA09_12735	COG2350	Protein conserved in bacteria
CDA09_12740	COG0271	Belongs to the BolA IbaG family
CDA09_12745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDA09_12750	COG1960	acyl-CoA dehydrogenase activity
CDA09_12765	COG1309	transcriptional regulator
CDA09_12770	COG0084	hydrolase, TatD family'
CDA09_12790	COG1127	ABC transporter
CDA09_12795	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CDA09_12805	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CDA09_12810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDA09_12840	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CDA09_12845	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CDA09_12855	COG1355	regulation of microtubule-based process
CDA09_12860	COG3885	ferrous iron binding
CDA09_12860	COG2078	PFAM AMMECR1 domain protein
CDA09_12865	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CDA09_12875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CDA09_12890	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CDA09_12895	COG4208	sulfate ABC transporter
CDA09_12900	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CDA09_12905	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CDA09_12915	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CDA09_12925	COG2353	YceI-like domain
CDA09_12940	COG0643	Histidine kinase
CDA09_12940	COG2198	Histidine kinase
CDA09_12945	COG2201	protein-glutamate methylesterase activity
CDA09_12955	COG1611	Belongs to the LOG family
CDA09_12975	COG2009	succinate dehydrogenase
CDA09_12985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CDA09_12990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDA09_12995	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CDA09_13040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CDA09_13060	COG4942	peptidase
CDA09_13070	COG4680	protein conserved in bacteria
CDA09_13075	COG0519	Catalyzes the synthesis of GMP from XMP
CDA09_13075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CDA09_13090	COG2914	Belongs to the UPF0125 (RnfH) family
CDA09_13095	COG2867	negative regulation of translational initiation
CDA09_13100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CDA09_13105	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CDA09_13110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDA09_13115	COG0601	transmembrane transport
CDA09_13130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDA09_13135	COG0542	response to heat
CDA09_13145	COG0314	molybdopterin synthase activity
CDA09_13150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CDA09_13155	COG0303	'Molybdopterin
CDA09_13160	COG1763	Mo-molybdopterin cofactor biosynthetic process
CDA09_13170	COG1199	ATP-dependent helicase activity
CDA09_13180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDA09_13185	COG0508	dehydrogenase complex catalyzes the overall conversion of
CDA09_13190	COG0567	Dehydrogenase, E1 component
CDA09_13200	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CDA09_13205	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CDA09_13210	COG1053	succinate dehydrogenase
CDA09_13225	COG2188	Transcriptional regulator
CDA09_13230	COG0039	L-malate dehydrogenase activity
CDA09_13240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CDA09_13255	COG1840	ABC-type Fe3 transport system, periplasmic component
CDA09_13270	COG1178	ABC-type Fe3 transport system permease component
CDA09_13275	COG3842	ATPase activity
CDA09_13280	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CDA09_13285	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CDA09_13290	COG0167	dihydroorotate dehydrogenase activity
CDA09_13295	COG4657	Part of a membrane complex involved in electron transport
CDA09_13300	COG2878	Part of a membrane complex involved in electron transport
CDA09_13310	COG4658	electron transport chain
CDA09_13315	COG4659	FMN binding
CDA09_13325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CDA09_13335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDA09_13355	COG0326	Molecular chaperone. Has ATPase activity
CDA09_13400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDA09_13415	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_13455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CDA09_13520	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CDA09_13540	COG2814	Major facilitator Superfamily
CDA09_13560	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_13565	COG1024	Enoyl-CoA hydratase
CDA09_13605	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDA09_13610	COG0179	Fumarylacetoacetate (FAA) hydrolase
CDA09_13645	COG2223	nitrite transmembrane transporter activity
CDA09_13650	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CDA09_13660	COG0179	Fumarylacetoacetate (FAA) hydrolase
CDA09_13665	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_13725	COG2086	electron transfer activity
CDA09_13735	COG0583	DNA-binding transcription factor activity
CDA09_13745	COG4974	Belongs to the 'phage' integrase family
CDA09_13750	COG0582	viral genome integration into host DNA
CDA09_13755	COG4974	Belongs to the 'phage' integrase family
CDA09_13760	COG0517	IMP dehydrogenase activity
CDA09_13770	COG4974	Belongs to the 'phage' integrase family
CDA09_13775	COG0582	viral genome integration into host DNA
CDA09_13780	COG4974	Belongs to the 'phage' integrase family
CDA09_13815	COG0302	gtp cyclohydrolase
CDA09_13825	COG1024	Enoyl-CoA hydratase
CDA09_13830	COG1960	acyl-CoA dehydrogenase activity
CDA09_13835	COG1960	acyl-CoA dehydrogenase activity
CDA09_13845	COG2124	cytochrome p450
CDA09_13850	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_13870	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_13875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDA09_13905	COG1233	COG1233 Phytoene dehydrogenase and related
CDA09_13930	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CDA09_13975	COG1192	Involved in chromosome partitioning
CDA09_14085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CDA09_14120	COG2003	Belongs to the UPF0758 family
CDA09_14160	COG4804	nuclease activity
CDA09_14225	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CDA09_14260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CDA09_14270	COG1185	polyribonucleotide nucleotidyltransferase activity
CDA09_14275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CDA09_14280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CDA09_14285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CDA09_14290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CDA09_14295	COG2251	uridine kinase activity
CDA09_14295	COG0195	Participates in both transcription termination and antitermination
CDA09_14300	COG0779	Required for maturation of 30S ribosomal subunits
CDA09_14310	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CDA09_14315	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CDA09_14320	COG0180	Tryptophanyl-tRNA synthetase
CDA09_14325	COG1994	Peptidase M50
CDA09_14330	COG0009	L-threonylcarbamoyladenylate synthase
CDA09_14335	COG0613	PHP domain protein
CDA09_14340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CDA09_14345	COG0509	glycine decarboxylation via glycine cleavage system
CDA09_14350	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CDA09_14350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CDA09_14365	COG1215	transferase activity, transferring glycosyl groups
CDA09_14370	COG0583	DNA-binding transcription factor activity
CDA09_14395	COG0488	(ABC) transporter
CDA09_14400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDA09_14405	COG3263	regulation of cellular component size
CDA09_14420	COG0577	efflux transmembrane transporter activity
CDA09_14420	COG1136	(ABC) transporter
CDA09_14425	COG1136	(ABC) transporter
CDA09_14435	COG3447	MASE1 domain protein
CDA09_14435	COG5001	Diguanylate cyclase
CDA09_14435	COG5002	protein histidine kinase activity
CDA09_14450	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CDA09_14455	COG4181	ATPase activity
CDA09_14465	COG0709	Synthesizes selenophosphate from selenide and ATP
CDA09_14470	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CDA09_14475	COG2204	response regulator
CDA09_14480	COG4191	Histidine kinase
CDA09_14485	COG1132	(ABC) transporter
CDA09_14500	COG0045	succinate-CoA ligase (ADP-forming) activity
CDA09_14500	COG1042	CoA-binding domain protein
CDA09_14500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CDA09_14510	COG2183	response to ionizing radiation
CDA09_14515	COG1393	Belongs to the ArsC family
CDA09_14525	COG0850	regulation of cytokinetic process
CDA09_14535	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CDA09_14545	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CDA09_14550	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CDA09_14550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDA09_14555	COG4585	Histidine kinase
CDA09_14560	COG2197	response regulator
CDA09_14590	COG0574	Belongs to the PEP-utilizing enzyme family
CDA09_14590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CDA09_14595	COG0517	IMP dehydrogenase activity
CDA09_14605	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CDA09_14620	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CDA09_14645	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CDA09_14660	COG2816	NAD+ diphosphatase activity
CDA09_14705	COG1960	acyl-CoA dehydrogenase activity
CDA09_14715	COG0183	Belongs to the thiolase family
CDA09_14720	COG1024	Enoyl-CoA hydratase
CDA09_14725	COG0318	PFAM AMP-dependent synthetase and ligase
CDA09_14740	COG0411	ABC transporter
CDA09_14750	COG1309	transcriptional regulator
CDA09_14760	COG5002	protein histidine kinase activity
CDA09_14780	COG0066	3-isopropylmalate dehydratase activity
CDA09_14790	COG2151	metal-sulfur cluster biosynthetic enzyme
CDA09_14800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CDA09_14805	COG0719	Fe-S assembly protein
CDA09_14810	COG0396	ATPase activity
CDA09_14815	COG0719	Fe-S assembly protein
CDA09_14820	COG1067	ATP-dependent peptidase activity
CDA09_14830	COG1881	PFAM PEBP family protein
CDA09_14850	COG2197	response regulator
CDA09_14865	COG1462	curli production assembly transport component CsgG
CDA09_14870	COG1881	PFAM PEBP family protein
CDA09_14890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CDA09_14895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CDA09_14905	COG1196	nuclear chromosome segregation
CDA09_14915	COG2171	N-acyltransferase activity
CDA09_14925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDA09_14940	COG0633	Ferredoxin
CDA09_14945	COG0443	Heat shock 70 kDa protein
CDA09_14950	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CDA09_14960	COG0822	iron-sulfur transferase activity
CDA09_14965	COG1104	cysteine desulfurase activity
CDA09_14970	COG1104	cysteine desulfurase activity
CDA09_14980	COG1045	serine acetyltransferase
CDA09_14995	COG0513	Belongs to the DEAD box helicase family
CDA09_15095	COG0583	DNA-binding transcription factor activity
CDA09_15115	COG4962	Type ii secretion system protein e
CDA09_15120	COG3838	Conjugal transfer protein Trbc
CDA09_15130	COG3451	type IV secretory pathway VirB4
CDA09_15155	COG2948	multi-organism process
CDA09_15185	COG0322	excinuclease ABC activity
CDA09_15190	COG1472	Belongs to the glycosyl hydrolase 3 family
CDA09_15195	COG0736	holo-[acyl-carrier-protein] synthase activity
CDA09_15200	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CDA09_15205	COG1381	Involved in DNA repair and RecF pathway recombination
CDA09_15210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CDA09_15215	COG0571	ribonuclease III activity
CDA09_15225	COG0681	Belongs to the peptidase S26 family
CDA09_15230	COG0481	GTPase activity
CDA09_15240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDA09_15265	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CDA09_15280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDA09_15295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CDA09_15300	COG0416	fatty acid biosynthetic process
CDA09_15305	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CDA09_15310	COG1399	metal-binding, possibly nucleic acid-binding protein
CDA09_15315	COG0424	maF-like protein
CDA09_15320	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CDA09_15335	COG1530	ribonuclease E activity
CDA09_15340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CDA09_15345	COG0556	nucleotide-excision repair
CDA09_15365	COG1067	ATP-dependent peptidase activity
CDA09_15375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CDA09_15390	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CDA09_15395	COG1473	amidohydrolase
CDA09_15410	COG0084	hydrolase, TatD family'
CDA09_15425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CDA09_15430	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CDA09_15455	COG0590	tRNA wobble adenosine to inosine editing
CDA09_15510	COG0243	molybdopterin cofactor binding
CDA09_15515	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CDA09_15520	COG3327	negative regulation of DNA-templated transcription, initiation
CDA09_15525	COG2814	Major facilitator Superfamily
CDA09_15535	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDA09_15540	COG1013	pyruvate-flavodoxin oxidoreductase activity
CDA09_15545	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CDA09_15545	COG0674	pyruvate-flavodoxin oxidoreductase activity
CDA09_15570	COG1012	belongs to the aldehyde dehydrogenase family
CDA09_15595	COG4974	Belongs to the 'phage' integrase family
CDA09_15600	COG0517	IMP dehydrogenase activity
CDA09_15625	COG2329	Antibiotic biosynthesis monooxygenase
CDA09_15630	COG1024	Enoyl-CoA hydratase
CDA09_15645	COG1742	UPF0060 membrane protein
CDA09_15660	COG2204	response regulator
CDA09_15670	COG2814	Major facilitator Superfamily
CDA09_15675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDA09_15685	COG1538	Outer membrane efflux protein
CDA09_15690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDA09_15695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDA09_15715	COG3474	cytochrome
CDA09_15720	COG0242	peptide deformylase activity
CDA09_15730	COG3145	DNA-N1-methyladenine dioxygenase activity
CDA09_15740	COG0776	regulation of translation
CDA09_15745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CDA09_15750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CDA09_15755	COG0740	serine-type endopeptidase activity
CDA09_15760	COG0544	peptidyl-prolyl cis-trans isomerase activity
CDA09_15765	COG2766	serine protein kinase
CDA09_15775	COG2719	SpoVR family
CDA09_15780	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CDA09_15780	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CDA09_15790	COG0697	spore germination
CDA09_15810	COG0436	Aminotransferase
CDA09_15820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CDA09_15825	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CDA09_15840	COG0791	NLP P60 protein
CDA09_15845	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CDA09_15855	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CDA09_15875	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CDA09_15880	COG3012	SEC-C Motif Domain Protein
CDA09_15915	COG3318	Belongs to the UPF0149 family
CDA09_15915	COG3012	SEC-C Motif Domain Protein
CDA09_15930	COG0254	rRNA binding
CDA09_15940	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CDA09_15945	COG0501	Belongs to the peptidase M48B family
CDA09_15950	COG1162	GTPase activity
CDA09_15955	COG0183	Belongs to the thiolase family
CDA09_15960	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CDA09_15965	COG3384	dioxygenase
CDA09_15975	COG1490	D-aminoacyl-tRNA deacylase activity
CDA09_16010	COG1027	Aspartate ammonia-lyase
CDA09_16025	COG1404	Belongs to the peptidase S8 family
CDA09_16030	COG1132	(ABC) transporter
CDA09_16055	COG1012	belongs to the aldehyde dehydrogenase family
CDA09_16070	COG2409	Drug exporters of the RND superfamily
CDA09_16095	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CDA09_16135	COG3259	Nickel-dependent hydrogenase
CDA09_16140	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
CDA09_16145	COG3383	formate dehydrogenase (NAD+) activity
CDA09_16150	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CDA09_16155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CDA09_16165	COG1007	ATP synthesis coupled electron transport
CDA09_16180	COG0713	ATP synthesis coupled electron transport
CDA09_16190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDA09_16195	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CDA09_16200	COG1034	ATP synthesis coupled electron transport
CDA09_16215	COG0649	NAD binding
CDA09_16220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDA09_16225	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDA09_16230	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDA09_16245	COG0149	triose-phosphate isomerase activity
CDA09_16250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDA09_16260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CDA09_16265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDA09_16275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDA09_16280	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CDA09_16285	COG1534	Rna-binding protein
CDA09_16290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CDA09_16295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CDA09_16300	COG0505	Belongs to the CarA family
CDA09_16305	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CDA09_16310	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDA09_16315	COG0735	belongs to the Fur family
CDA09_16320	COG0497	DNA recombination
CDA09_16325	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CDA09_16330	COG1420	regulation of RNA biosynthetic process
CDA09_16335	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CDA09_16345	COG0515	serine threonine protein kinase
CDA09_16345	COG2815	serine threonine protein kinase
CDA09_16350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CDA09_16355	COG0443	Heat shock 70 kDa protein
CDA09_16360	COG0484	heat shock protein binding
CDA09_16365	COG0215	cysteine-tRNA ligase activity
CDA09_16385	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CDA09_16390	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDA09_16410	COG0285	dihydrofolate synthase activity
CDA09_16415	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CDA09_16420	COG0159	tryptophan synthase activity
CDA09_16425	COG0133	tryptophan synthase activity
CDA09_16430	COG0135	phosphoribosylanthranilate isomerase activity
CDA09_16435	COG0101	tRNA pseudouridine synthase activity
CDA09_16455	COG0473	3-isopropylmalate dehydrogenase activity
CDA09_16460	COG0066	3-isopropylmalate dehydratase activity
CDA09_16465	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CDA09_16470	COG4783	chaperone-mediated protein folding
CDA09_16475	COG2814	Major facilitator Superfamily
CDA09_16480	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CDA09_16485	COG0440	acetolactate synthase activity
CDA09_16490	COG0028	Belongs to the TPP enzyme family
CDA09_16495	COG0318	PFAM AMP-dependent synthetase and ligase
CDA09_16505	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CDA09_16515	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CDA09_16520	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDA09_16555	COG0277	FAD linked oxidase domain protein
CDA09_16560	COG1752	Esterase of the alpha-beta hydrolase superfamily
CDA09_16565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDA09_16570	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CDA09_16580	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_16585	COG3243	poly(R)-hydroxyalkanoic acid synthase
CDA09_16600	COG0564	pseudouridine synthase activity
CDA09_16615	COG2951	lytic endotransglycosylase activity
CDA09_16630	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_16635	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDA09_16645	COG1473	amidohydrolase
CDA09_16650	COG2860	membrane
CDA09_16670	COG4657	Part of a membrane complex involved in electron transport
CDA09_16675	COG2878	Part of a membrane complex involved in electron transport
CDA09_16685	COG4658	electron transport chain
CDA09_16690	COG4659	FMN binding
CDA09_16715	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CDA09_16720	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CDA09_16730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CDA09_16735	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CDA09_16740	COG1674	ftsk spoiiie
CDA09_16750	COG0492	ferredoxin-NADP+ reductase activity
CDA09_16755	COG2840	Smr protein MutS2
CDA09_16765	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CDA09_16765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CDA09_16785	COG2217	Heavy metal translocating P-type atpase
CDA09_16800	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CDA09_16805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDA09_16815	COG3094	Invasion gene expression up-regulator, SirB
CDA09_16825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDA09_16830	COG3243	poly(R)-hydroxyalkanoic acid synthase
CDA09_16835	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CDA09_16860	COG2010	Cytochrome c
CDA09_16875	COG3278	Belongs to the heme-copper respiratory oxidase family
CDA09_16885	COG2217	Heavy metal translocating P-type atpase
CDA09_16895	COG0494	nUDIX hydrolase
CDA09_16905	COG2972	Histidine kinase
CDA09_16905	COG0745	RESPONSE REGULATOR receiver
CDA09_16940	COG4968	Prepilin-type N-terminal cleavage methylation domain
CDA09_16945	COG0588	phosphoglycerate mutase activity
CDA09_16960	COG1960	acyl-CoA dehydrogenase activity
CDA09_16965	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDA09_16970	COG0183	Belongs to the thiolase family
CDA09_16985	COG0183	Belongs to the thiolase family
CDA09_17000	COG2814	Major facilitator Superfamily
CDA09_17010	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_17015	COG1960	acyl-CoA dehydrogenase activity
CDA09_17020	COG1960	acyl-CoA dehydrogenase activity
CDA09_17035	COG2130	NADP-dependent
CDA09_17040	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDA09_17040	COG1024	Enoyl-CoA hydratase
CDA09_17045	COG0183	Belongs to the thiolase family
CDA09_17050	COG1024	Enoyl-CoA hydratase
CDA09_17060	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_17065	COG0318	PFAM AMP-dependent synthetase and ligase
CDA09_17085	COG2814	Major facilitator Superfamily
CDA09_17090	COG1053	succinate dehydrogenase
CDA09_17145	COG2814	Major facilitator Superfamily
CDA09_17150	COG1960	acyl-CoA dehydrogenase activity
CDA09_17155	COG1960	acyl-CoA dehydrogenase activity
CDA09_17160	COG3039	Transposase
CDA09_17190	COG0527	aspartate kinase activity
CDA09_17205	COG0720	synthase
CDA09_17210	COG3264	Mechanosensitive ion channel
CDA09_17210	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CDA09_17215	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CDA09_17220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CDA09_17220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CDA09_17230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CDA09_17235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CDA09_17265	COG0187	DNA topoisomerase II activity
CDA09_17275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CDA09_17280	COG1984	allophanate hydrolase subunit 2
CDA09_17285	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CDA09_17295	COG4336	lyase activity
CDA09_17315	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CDA09_17320	COG1191	sigma factor activity
CDA09_17335	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CDA09_17340	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CDA09_17360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CDA09_17375	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CDA09_17380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDA09_17385	COG0123	including yeast histone deacetylase and acetoin utilization protein
CDA09_17390	COG0714	Associated with various cellular activities
CDA09_17405	COG2951	lytic endotransglycosylase activity
CDA09_17410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CDA09_17420	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CDA09_17425	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CDA09_17440	COG0776	regulation of translation
CDA09_17445	COG0072	phenylalanine-tRNA ligase activity
CDA09_17445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDA09_17450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CDA09_17455	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CDA09_17460	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CDA09_17465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CDA09_17470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CDA09_17485	COG0535	radical SAM domain protein
CDA09_17505	COG3391	amine dehydrogenase activity
CDA09_17515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CDA09_17515	COG1648	precorrin-2 dehydrogenase activity
CDA09_17540	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CDA09_17550	COG0776	regulation of translation
CDA09_17560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CDA09_17565	COG0287	Prephenate dehydrogenase
CDA09_17575	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CDA09_17585	COG0402	S-adenosylhomocysteine deaminase activity
CDA09_17595	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CDA09_17645	COG0346	lactoylglutathione lyase activity
CDA09_17665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CDA09_17685	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CDA09_17700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CDA09_17720	COG0494	nUDIX hydrolase
CDA09_17725	COG0071	Belongs to the small heat shock protein (HSP20) family
CDA09_17730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CDA09_17735	COG1218	3'(2'),5'-bisphosphate nucleotidase
CDA09_17740	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDA09_17755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDA09_17760	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDA09_17770	COG1999	signal sequence binding
CDA09_17775	COG0109	protoheme IX farnesyltransferase activity
CDA09_17805	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CDA09_17810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CDA09_17820	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CDA09_17835	COG0514	ATP-dependent DNA helicase (RecQ)
CDA09_17840	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CDA09_17845	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CDA09_17865	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDA09_17880	COG2207	Transcriptional regulator
CDA09_17880	COG1917	Cupin 2, conserved barrel domain protein
CDA09_17885	COG0443	Heat shock 70 kDa protein
CDA09_17905	COG0411	ABC transporter
CDA09_17925	COG0643	Histidine kinase
CDA09_17925	COG2198	Histidine kinase
CDA09_17930	COG2201	protein-glutamate methylesterase activity
CDA09_17940	COG1522	sequence-specific DNA binding
CDA09_17950	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDA09_17960	COG0134	indole-3-glycerol-phosphate synthase activity
CDA09_17965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDA09_17980	COG0546	phosphoglycolate phosphatase activity
CDA09_17990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CDA09_17995	COG1234	tRNA 3'-trailer cleavage
CDA09_18000	COG1716	ATPase activity
CDA09_18005	COG0631	protein serine/threonine phosphatase activity
CDA09_18010	COG2423	ornithine cyclodeaminase activity
CDA09_18035	COG4566	intracellular signal transduction
CDA09_18040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CDA09_18045	COG0037	tRNA processing
CDA09_18050	COG0825	malonyl-CoA metabolic process
CDA09_18055	COG1253	flavin adenine dinucleotide binding
CDA09_18060	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CDA09_18065	COG0670	Belongs to the BI1 family
CDA09_18080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CDA09_18085	COG0343	queuine tRNA-ribosyltransferase activity
CDA09_18090	COG1862	Preprotein translocase
CDA09_18095	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CDA09_18100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CDA09_18105	COG2095	MarC family integral membrane protein
CDA09_18120	COG2967	ApaG domain
CDA09_18125	COG0784	Response regulator, receiver
CDA09_18125	COG4191	Histidine kinase
CDA09_18130	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CDA09_18140	COG0653	protein targeting
CDA09_18155	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CDA09_18160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CDA09_18170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CDA09_18175	COG1181	Belongs to the D-alanine--D-alanine ligase family
CDA09_18180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CDA09_18185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CDA09_18190	COG0772	Belongs to the SEDS family
CDA09_18195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CDA09_18200	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CDA09_18205	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CDA09_18210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CDA09_18225	COG0275	rRNA processing
CDA09_18230	COG2001	Belongs to the MraZ family
CDA09_18245	COG0418	dihydroorotase activity
CDA09_18255	COG0792	nuclease activity
CDA09_18260	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CDA09_18265	COG2823	Periplasmic or secreted lipoprotein
CDA09_18270	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CDA09_18285	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CDA09_18295	COG0439	Biotin carboxylase
CDA09_18300	COG2264	protein methyltransferase activity
CDA09_18315	COG3133	Outer membrane lipoprotein
CDA09_18325	COG0537	adenosine 5'-monophosphoramidase activity
CDA09_18340	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CDA09_18350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CDA09_18400	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
CDA09_18405	COG2076	Multidrug Resistance protein
CDA09_18445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CDA09_18460	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CDA09_18460	COG0662	Cupin 2, conserved barrel domain protein
CDA09_18490	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CDA09_18495	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CDA09_18510	COG1309	transcriptional regulator
CDA09_18520	COG2119	membrane
CDA09_18525	COG0351	phosphomethylpyrimidine kinase
CDA09_18530	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CDA09_18545	COG2022	thiamine diphosphate biosynthetic process
CDA09_18555	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CDA09_18565	COG0022	dehydrogenase e1 component
CDA09_18570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CDA09_18595	COG0318	PFAM AMP-dependent synthetase and ligase
CDA09_18610	COG2610	gluconate transmembrane transporter activity
CDA09_18640	COG1968	undecaprenyl-diphosphatase activity
CDA09_18645	COG3150	esterase
CDA09_18650	COG2226	methyltransferase
CDA09_18655	COG2962	Rard protein
CDA09_18660	COG0557	exoribonuclease II activity
CDA09_18670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CDA09_18675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CDA09_18680	COG2239	Acts as a magnesium transporter
CDA09_18685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CDA09_18690	COG0352	thiamine-phosphate diphosphorylase activity
CDA09_18730	COG1678	Uncharacterized ACR, COG1678
CDA09_18735	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CDA09_18740	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CDA09_18745	COG0540	Belongs to the ATCase OTCase family
CDA09_18755	COG1872	DUF167
CDA09_18760	COG0762	integral membrane protein
CDA09_18805	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
CDA09_18810	COG4654	Cytochrome c, class I
CDA09_18815	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CDA09_18815	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CDA09_18830	COG2200	EAL domain
CDA09_18840	COG2197	response regulator
CDA09_18845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDA09_18850	COG2274	protein secretion by the type I secretion system
CDA09_18855	COG0735	belongs to the Fur family
CDA09_18860	COG1121	(ABC) transporter
CDA09_18875	COG1280	lysine exporter protein (LysE YggA)
CDA09_18885	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CDA09_18895	COG0129	dihydroxy-acid dehydratase activity
CDA09_18900	COG3132	Protein of unknown function, DUF480
CDA09_18905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CDA09_18965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDA09_18970	COG1136	(ABC) transporter
CDA09_18970	COG0577	efflux transmembrane transporter activity
CDA09_19045	COG5002	protein histidine kinase activity
CDA09_19050	COG0745	RESPONSE REGULATOR receiver
CDA09_19075	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDA09_19145	COG4969	Belongs to the N-Me-Phe pilin family
CDA09_19155	COG3744	PilT protein domain protein
CDA09_19165	COG3609	addiction module antidote protein, CC2985 family
CDA09_19225	COG0436	Aminotransferase
CDA09_19230	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CDA09_19235	COG0235	Class ii aldolase
CDA09_19240	COG2084	Dehydrogenase
CDA09_19245	COG2084	Dehydrogenase
CDA09_19250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDA09_19260	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CDA09_19265	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CDA09_19295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CDA09_19310	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CDA09_19330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDA09_19355	COG4647	ligase activity
CDA09_19360	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CDA09_19365	COG0145	ligase activity
CDA09_19370	COG0629	single-stranded DNA binding
CDA09_19375	COG2814	Major facilitator Superfamily
CDA09_19390	COG0203	ribosomal protein L17
CDA09_19395	COG0202	RNA polymerase activity
CDA09_19400	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CDA09_19405	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CDA09_19410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CDA09_19415	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CDA09_19420	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CDA09_19425	COG0201	protein transport
CDA09_19430	COG0200	Binds to the 23S rRNA
CDA09_19435	COG1841	ribosomal large subunit assembly
CDA09_19440	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CDA09_19445	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CDA09_19450	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CDA09_19455	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CDA09_19460	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CDA09_19465	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CDA09_19470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CDA09_19475	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CDA09_19480	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CDA09_19485	COG0255	Belongs to the universal ribosomal protein uL29 family
CDA09_19490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CDA09_19495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CDA09_19500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CDA09_19505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CDA09_19510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CDA09_19515	COG0089	rRNA binding
CDA09_19520	COG0088	Forms part of the polypeptide exit tunnel
CDA09_19525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CDA09_19530	COG0051	transcription antitermination factor activity, RNA binding
CDA09_19535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CDA09_19540	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CDA09_19545	COG0049	tRNA binding
CDA09_19550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CDA09_19555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CDA09_19560	COG0085	RNA polymerase activity
CDA09_19565	COG0222	ribosome binding
CDA09_19570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CDA09_19575	COG0081	regulation of translation
CDA09_19580	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CDA09_19590	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CDA09_19600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CDA09_19620	COG0277	FAD linked oxidase domain protein
CDA09_19645	COG0784	Response regulator, receiver
CDA09_19645	COG2205	protein histidine kinase activity
CDA09_19645	COG2198	Histidine kinase
CDA09_19675	COG1032	radical SAM domain protein
CDA09_19680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CDA09_19690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CDA09_19700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDA09_19705	COG1116	anion transmembrane transporter activity
CDA09_19730	COG0559	Belongs to the binding-protein-dependent transport system permease family
CDA09_19735	COG0411	ABC transporter
CDA09_19740	COG1022	Amp-dependent synthetase and ligase
CDA09_19775	COG0586	Pfam SNARE associated Golgi protein
CDA09_19785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CDA09_19790	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CDA09_19790	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CDA09_19790	COG1703	isobutyryl-CoA mutase activity
CDA09_19800	COG0784	Response regulator, receiver
CDA09_19800	COG4191	Histidine kinase
CDA09_19830	COG3158	transport of potassium into the cell
CDA09_19835	COG0745	RESPONSE REGULATOR receiver
CDA09_19840	COG2205	protein histidine kinase activity
CDA09_19850	COG2321	neutral zinc metallopeptidase
CDA09_19865	COG2197	response regulator
CDA09_19875	COG1999	signal sequence binding
CDA09_19880	COG2197	response regulator
CDA09_19885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDA09_19905	COG0439	Biotin carboxylase
CDA09_19910	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CDA09_19915	COG1703	isobutyryl-CoA mutase activity
CDA09_19920	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CDA09_19920	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CDA09_19925	COG1802	Transcriptional regulator
CDA09_19930	COG0114	fumarate hydratase activity
CDA09_19945	COG2197	response regulator
CDA09_19990	COG4964	Belongs to the GSP D family
CDA09_20040	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CDA09_20045	COG3162	membrane
CDA09_20050	COG1024	Enoyl-CoA hydratase
CDA09_20055	COG1492	cobalamin metabolic process
CDA09_20060	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CDA09_20070	COG1242	4 iron, 4 sulfur cluster binding
CDA09_20075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CDA09_20085	COG0513	Belongs to the DEAD box helicase family
CDA09_20110	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CDA09_20155	COG0427	acetyl-CoA hydrolase
CDA09_20160	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CDA09_20165	COG0019	diaminopimelate decarboxylase activity
CDA09_20200	COG0583	DNA-binding transcription factor activity
CDA09_20205	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_20210	COG1280	lysine exporter protein (LysE YggA)
CDA09_20225	COG0545	Peptidyl-prolyl cis-trans isomerase
CDA09_20245	COG3038	cytochrome b561
CDA09_20260	COG0671	phosphoesterase, PA-phosphatase related
CDA09_20265	COG0671	phosphoesterase, PA-phosphatase related
CDA09_20290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CDA09_20300	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CDA09_20310	COG0067	glutamate synthase
CDA09_20310	COG0070	glutamate synthase
CDA09_20310	COG0069	glutamate synthase activity
CDA09_20315	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CDA09_20320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CDA09_20325	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CDA09_20360	COG1965	Belongs to the frataxin family
CDA09_20410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CDA09_20415	COG0284	orotidine-5'-phosphate decarboxylase activity
CDA09_20425	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CDA09_20430	COG3161	chorismate lyase activity
CDA09_20435	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CDA09_20445	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CDA09_20465	COG1741	Belongs to the pirin family
CDA09_20470	COG0778	Nitroreductase
CDA09_20480	COG0642	Histidine kinase
CDA09_20510	COG0183	Belongs to the thiolase family
CDA09_20515	COG1024	Enoyl-CoA hydratase
CDA09_20515	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDA09_20520	COG2067	long-chain fatty acid transport protein
CDA09_20525	COG1607	acyl-coa hydrolase
CDA09_20530	COG1024	Enoyl-CoA hydratase
CDA09_20530	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDA09_20535	COG0183	Belongs to the thiolase family
CDA09_20540	COG1960	acyl-CoA dehydrogenase activity
CDA09_20545	COG1309	transcriptional regulator
CDA09_20560	COG4178	(ABC) transporter
CDA09_20570	COG0366	Alpha amylase catalytic
CDA09_20575	COG1322	Protein conserved in bacteria
CDA09_20580	COG5265	(ABC) transporter
CDA09_20590	COG0252	asparaginase activity
CDA09_20595	COG0583	DNA-binding transcription factor activity
CDA09_20600	COG0730	response to heat
CDA09_20615	COG0175	sulfate reduction
CDA09_20620	COG0175	sulfate reduction
CDA09_20625	COG2895	sulfate adenylyltransferase (ATP) activity
CDA09_20640	COG0330	HflC and HflK could
CDA09_20645	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CDA09_20650	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CDA09_20660	COG0824	Thioesterase
CDA09_20680	COG0823	Involved in the tonB-independent uptake of proteins
CDA09_20685	COG2885	chlorophyll binding
CDA09_20695	COG0602	queuosine metabolic process
CDA09_20700	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CDA09_20710	COG2204	response regulator
CDA09_20780	COG5001	Diguanylate cyclase
CDA09_20780	COG3300	MHYT domain
CDA09_20785	COG0318	PFAM AMP-dependent synthetase and ligase
CDA09_20810	COG4214	carbohydrate transport
CDA09_20820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CDA09_20825	COG1546	Belongs to the CinA family
CDA09_20830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CDA09_20835	COG2137	regulation of response to DNA damage stimulus
CDA09_20840	COG1137	ATPase activity
CDA09_20845	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CDA09_20850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CDA09_20860	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CDA09_20865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CDA09_20870	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CDA09_20875	COG0741	lytic transglycosylase activity
CDA09_20890	COG0617	tRNA 3'-terminal CCA addition
CDA09_20915	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_20920	COG0037	tRNA processing
CDA09_20930	COG1238	metal cluster binding
CDA09_20935	COG0251	oxidation-reduction process
CDA09_20950	COG0243	molybdopterin cofactor binding
CDA09_20960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CDA09_20965	COG0708	Exodeoxyribonuclease III
CDA09_20995	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CDA09_21025	COG1203	CRISPR-associated helicase, Cas3
CDA09_21040	COG1857	crispr-associated protein
CDA09_21065	COG1518	maintenance of DNA repeat elements
CDA09_21070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CDA09_21085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CDA09_21105	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CDA09_21115	COG0861	Integral membrane protein TerC family
CDA09_21135	COG3876	Protein conserved in bacteria
CDA09_21145	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CDA09_21200	COG0411	ABC transporter
CDA09_21215	COG2814	Major facilitator Superfamily
CDA09_21220	COG0606	chelatase, subunit chli
CDA09_21235	COG0347	Belongs to the P(II) protein family
CDA09_21240	COG0004	ammonium transporteR
CDA09_21255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CDA09_21260	COG0488	(ABC) transporter
CDA09_21280	COG0189	ligase activity
CDA09_21290	COG0827	DNA restriction-modification system
CDA09_21290	COG0732	type I restriction modification DNA specificity domain
CDA09_21310	COG1561	YicC-like family, N-terminal region
CDA09_21315	COG0515	serine threonine protein kinase
CDA09_21315	COG2815	serine threonine protein kinase
CDA09_21320	COG0631	protein serine/threonine phosphatase activity
CDA09_21325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CDA09_21330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CDA09_21335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CDA09_21340	COG0616	signal peptide processing
CDA09_21345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CDA09_21350	COG2022	thiamine diphosphate biosynthetic process
CDA09_21365	COG0582	viral genome integration into host DNA
CDA09_21375	COG1396	sequence-specific DNA binding
CDA09_21380	COG0583	DNA-binding transcription factor activity
CDA09_21400	COG3436	PFAM IS66 Orf2 family protein
CDA09_21405	COG4372	Transposase
CDA09_21410	COG3012	SEC-C Motif Domain Protein
CDA09_21415	COG2267	carboxylic ester hydrolase activity
CDA09_21430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDA09_21435	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CDA09_21445	COG0346	lactoylglutathione lyase activity
CDA09_21460	COG2146	nitrite reductase [NAD(P)H] activity
CDA09_21480	COG1802	Transcriptional regulator
CDA09_21505	COG1733	regulation of RNA biosynthetic process
CDA09_21525	COG1902	pentaerythritol trinitrate reductase activity
CDA09_21530	COG0842	Transport permease protein
CDA09_21535	COG0842	Transport permease protein
CDA09_21535	COG1129	ABC transporter
CDA09_21540	COG1129	ABC transporter
CDA09_21540	COG0842	Transport permease protein
CDA09_21545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDA09_21560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDA09_21565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CDA09_21575	COG1752	Esterase of the alpha-beta hydrolase superfamily
CDA09_21655	COG2003	Belongs to the UPF0758 family
CDA09_21720	COG2814	Major facilitator Superfamily
CDA09_21730	COG1024	Enoyl-CoA hydratase
CDA09_21740	COG1960	acyl-CoA dehydrogenase activity
CDA09_21745	COG0427	acetyl-CoA hydrolase
CDA09_21750	COG1960	acyl-CoA dehydrogenase activity
CDA09_21755	COG1013	pyruvate-flavodoxin oxidoreductase activity
CDA09_21760	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CDA09_21760	COG0674	pyruvate-flavodoxin oxidoreductase activity
CDA09_21765	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDA09_21790	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDA09_21795	COG1024	Enoyl-CoA hydratase
CDA09_21800	COG0183	Belongs to the thiolase family
CDA09_21840	COG0559	Belongs to the binding-protein-dependent transport system permease family
CDA09_21850	COG0411	ABC transporter
CDA09_21865	COG1309	transcriptional regulator
CDA09_21950	COG1881	PFAM PEBP family protein
CDA09_21955	COG1024	Enoyl-CoA hydratase
CDA09_21980	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_21985	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_22075	COG0776	regulation of translation
CDA09_22105	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CDA09_22155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CDA09_22200	COG1192	Involved in chromosome partitioning
CDA09_22220	COG2032	superoxide dismutase activity
CDA09_22225	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDA09_22230	COG1194	a g-specific adenine glycosylase
CDA09_22240	COG0163	prenyltransferase activity
CDA09_22255	COG0559	Belongs to the binding-protein-dependent transport system permease family
CDA09_22260	COG2860	membrane
CDA09_22265	COG1970	mechanosensitive ion channel activity
CDA09_22270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDA09_22275	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CDA09_22335	COG1215	transferase activity, transferring glycosyl groups
CDA09_22340	COG0726	polysaccharide deacetylase
CDA09_22340	COG1649	PFAM Uncharacterised BCR, COG1649
CDA09_22440	COG4633	Protein conserved in bacteria
CDA09_22460	COG3383	formate dehydrogenase (NAD+) activity
CDA09_22470	COG0583	DNA-binding transcription factor activity
CDA09_22480	COG3040	lipid binding
CDA09_22500	COG1846	Transcriptional regulator
CDA09_22505	COG1538	Outer membrane efflux protein
CDA09_22510	COG1566	PFAM secretion protein HlyD family protein
CDA09_22525	COG2197	response regulator
CDA09_22535	COG2336	PFAM SpoVT AbrB
CDA09_22550	COG4453	Protein conserved in bacteria
CDA09_22585	COG1309	transcriptional regulator
CDA09_22590	COG1024	Enoyl-CoA hydratase
CDA09_22595	COG1024	Enoyl-CoA hydratase
CDA09_22600	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_22625	COG1960	acyl-CoA dehydrogenase activity
CDA09_22630	COG1028	Short-chain dehydrogenase reductase Sdr
CDA09_22665	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDA09_22670	COG1773	rubredoxin
CDA09_22695	COG0411	ABC transporter
CDA09_22730	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CDA09_22755	COG0840	transmembrane signaling receptor activity
CDA09_22790	COG0488	(ABC) transporter
CDA09_22795	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CDA09_22800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CDA09_22805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CDA09_22810	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDA09_22825	COG2814	Major facilitator Superfamily
CDA09_22840	COG0840	transmembrane signaling receptor activity
CDA09_22855	COG2258	MOSC domain
CDA09_22880	COG0309	Hydrogenase expression formation protein (HypE)
CDA09_22885	COG0409	Hydrogenase expression formation protein
CDA09_22890	COG0298	carbon dioxide binding
CDA09_22895	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CDA09_22905	COG0375	protein maturation
CDA09_22915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CDA09_22920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CDA09_22935	COG0830	nickel cation binding
CDA09_22940	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CDA09_22945	COG0804	urea catabolic process
CDA09_22950	COG0832	Belongs to the urease beta subunit family
CDA09_22955	COG0831	urea catabolic process
CDA09_22960	COG0829	nickel cation binding
CDA09_22980	COG0559	Belongs to the binding-protein-dependent transport system permease family
CDA09_22990	COG0840	transmembrane signaling receptor activity
CDA09_22995	COG2204	response regulator
CDA09_23000	COG5000	phosphorelay sensor kinase activity
CDA09_23010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CDA09_23015	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CDA09_23020	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CDA09_23025	COG0706	membrane insertase activity
CDA09_23030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CDA09_23035	COG0594	ribonuclease P activity
CDA09_23105	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity