locus-tag	class	description
AZKH_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AZKH_0002	COG0592	DNA-directed DNA polymerase activity
AZKH_0006	COG0517	IMP dehydrogenase activity
AZKH_0006	COG0516	GMP reductase activity
AZKH_0011	COG3706	GGDEF domain
AZKH_0011	COG0745	RESPONSE REGULATOR receiver
AZKH_0015	COG3706	GGDEF domain
AZKH_0015	COG0745	RESPONSE REGULATOR receiver
AZKH_0016	COG5002	protein histidine kinase activity
AZKH_0016	COG5001	Diguanylate cyclase
AZKH_0016	COG3447	MASE1 domain protein
AZKH_0020	COG3842	ATPase activity
AZKH_0022	COG1176	ABC-type spermidine putrescine transport system, permease component I
AZKH_0025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AZKH_0027	COG3706	GGDEF domain
AZKH_0028	COG0583	DNA-binding transcription factor activity
AZKH_0029	COG1960	acyl-CoA dehydrogenase activity
AZKH_0030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AZKH_0031	COG0745	RESPONSE REGULATOR receiver
AZKH_0033	COG2974	May be involved in recombination
AZKH_0035	COG1187	pseudouridine synthase activity
AZKH_0037	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AZKH_0039	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AZKH_0042	COG0784	Response regulator, receiver
AZKH_0044	COG0564	pseudouridine synthase activity
AZKH_0045	COG3909	cytochrome
AZKH_0046	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZKH_0048	COG4566	intracellular signal transduction
AZKH_0049	COG4206	TonB-dependent receptor
AZKH_0051	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AZKH_0052	COG0551	DNA topoisomerase type I activity
AZKH_0052	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AZKH_0053	COG2922	Belongs to the Smg family
AZKH_0054	COG0758	DNA mediated transformation
AZKH_0056	COG0242	peptide deformylase activity
AZKH_0057	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AZKH_0061	COG1763	Mo-molybdopterin cofactor biosynthetic process
AZKH_0068	COG0746	molybdenum cofactor guanylyltransferase activity
AZKH_0069	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AZKH_0075	COG0243	molybdopterin cofactor binding
AZKH_0075	COG3383	formate dehydrogenase (NAD+) activity
AZKH_0076	COG0437	4 iron, 4 sulfur cluster binding
AZKH_0081	COG1234	tRNA 3'-trailer cleavage
AZKH_0087	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZKH_0088	COG0765	amino acid transport
AZKH_0089	COG0765	amino acid transport
AZKH_0090	COG1126	abc transporter atp-binding protein
AZKH_0092	COG2824	Alkylphosphonate utilization operon protein PhnA
AZKH_0095	COG0583	DNA-binding transcription factor activity
AZKH_0096	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AZKH_0107	COG0445	tRNA wobble uridine modification
AZKH_0108	COG0357	Ribosomal RNA small subunit methyltransferase G
AZKH_0109	COG1192	Involved in chromosome partitioning
AZKH_0110	COG1475	DNA binding
AZKH_0112	COG0356	it plays a direct role in the translocation of protons across the membrane
AZKH_0114	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AZKH_0115	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AZKH_0116	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AZKH_0117	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AZKH_0118	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AZKH_0119	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AZKH_0121	COG2226	methyltransferase
AZKH_0127	COG0121	glutamine amidotransferase
AZKH_0128	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AZKH_0130	COG0154	amidase activity
AZKH_0131	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AZKH_0132	COG1077	Cell shape determining protein MreB Mrl
AZKH_0135	COG0768	penicillin binding
AZKH_0136	COG0772	Belongs to the SEDS family
AZKH_0138	COG1686	Belongs to the peptidase S11 family
AZKH_0140	COG2921	Belongs to the UPF0250 family
AZKH_0141	COG0321	lipoyl(octanoyl) transferase activity
AZKH_0142	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AZKH_0143	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AZKH_0148	COG1652	LysM domain
AZKH_0150	COG2194	sulfuric ester hydrolase activity
AZKH_0161	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AZKH_0163	COG3901	Regulator of nitric oxide reductase transcription
AZKH_0163	COG0348	domain, Protein
AZKH_0167	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AZKH_0169	COG0583	DNA-binding transcription factor activity
AZKH_0175	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_0179	COG3963	phosphatidate phosphatase activity
AZKH_0181	COG1845	cytochrome c oxidase, subunit III
AZKH_0183	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AZKH_0184	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AZKH_0191	COG2814	Major facilitator Superfamily
AZKH_0196	COG2045	Belongs to the ComB family
AZKH_0202	COG2733	membrane
AZKH_0203	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AZKH_0204	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AZKH_0210	COG2205	protein histidine kinase activity
AZKH_0212	COG2205	protein histidine kinase activity
AZKH_0220	COG2204	response regulator
AZKH_0227	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AZKH_0229	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AZKH_0231	COG0583	DNA-binding transcription factor activity
AZKH_0232	COG1368	sulfuric ester hydrolase activity
AZKH_0233	COG0300	oxidoreductase activity
AZKH_0239	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
AZKH_0246	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AZKH_0253	COG0662	Cupin 2, conserved barrel domain protein
AZKH_0253	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AZKH_0254	COG0156	8-amino-7-oxononanoate synthase activity
AZKH_0256	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AZKH_0257	COG3842	ATPase activity
AZKH_0258	COG1176	ABC-type spermidine putrescine transport system, permease component I
AZKH_0259	COG1177	transmembrane transport
AZKH_0260	COG1132	(ABC) transporter
AZKH_0265	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AZKH_0266	COG1074	ATP-dependent DNA helicase activity
AZKH_0267	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AZKH_0269	COG1278	Cold shock
AZKH_0271	COG0330	HflC and HflK could
AZKH_0280	COG0477	Major facilitator Superfamily
AZKH_0282	COG1305	Transglutaminase-like
AZKH_0283	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AZKH_0285	COG3045	CreA protein
AZKH_0289	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AZKH_0290	COG0484	heat shock protein binding
AZKH_0292	COG0194	GDP metabolic process
AZKH_0293	COG1758	RNA polymerase activity
AZKH_0294	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AZKH_0295	COG0523	cobalamin synthesis protein
AZKH_0296	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AZKH_0299	COG2176	DNA-directed DNA polymerase activity
AZKH_0299	COG5002	protein histidine kinase activity
AZKH_0301	COG3850	Histidine kinase
AZKH_0302	COG2197	response regulator
AZKH_0305	COG0243	molybdopterin cofactor binding
AZKH_0306	COG0437	4 iron, 4 sulfur cluster binding
AZKH_0307	COG0348	domain, Protein
AZKH_0309	COG3005	denitrification pathway
AZKH_0310	COG4133	protoheme IX ABC transporter activity
AZKH_0313	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AZKH_0314	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AZKH_0316	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AZKH_0317	COG3088	subunit of a heme lyase
AZKH_0323	COG2204	response regulator
AZKH_0324	COG4191	Histidine kinase
AZKH_0329	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AZKH_0331	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AZKH_0350	COG3245	cytochrome
AZKH_0361	COG2226	methyltransferase
AZKH_0370	COG0714	Associated with various cellular activities
AZKH_0372	COG0463	Glycosyl transferase, family 2
AZKH_0375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AZKH_0385	COG3706	GGDEF domain
AZKH_0387	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AZKH_0392	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AZKH_0393	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AZKH_0399	COG1368	sulfuric ester hydrolase activity
AZKH_0408	COG0745	RESPONSE REGULATOR receiver
AZKH_0408	COG3706	GGDEF domain
AZKH_0409	COG1012	belongs to the aldehyde dehydrogenase family
AZKH_0410	COG1024	Enoyl-CoA hydratase
AZKH_0411	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_0412	COG2050	protein possibly involved in aromatic compounds catabolism
AZKH_0414	COG3396	Phenylacetate-CoA oxygenase
AZKH_0415	COG3460	Phenylacetate-CoA oxygenase
AZKH_0416	COG3396	Phenylacetate-CoA oxygenase
AZKH_0417	COG2151	metal-sulfur cluster biosynthetic enzyme
AZKH_0418	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AZKH_0423	COG0411	ABC transporter
AZKH_0425	COG3501	Rhs element vgr protein
AZKH_0428	COG0583	DNA-binding transcription factor activity
AZKH_0429	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AZKH_0437	COG0513	Belongs to the DEAD box helicase family
AZKH_0438	COG1448	Aminotransferase
AZKH_0439	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AZKH_0440	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AZKH_0443	COG4232	protein-disulfide reductase activity
AZKH_0444	COG1324	tolerance protein
AZKH_0445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
AZKH_0460	COG2814	Major facilitator Superfamily
AZKH_0468	COG0861	Integral membrane protein TerC family
AZKH_0471	COG3842	ATPase activity
AZKH_0472	COG0604	alcohol dehydrogenase
AZKH_0473	COG1309	transcriptional regulator
AZKH_0477	COG0625	glutathione transferase activity
AZKH_0485	COG1309	transcriptional regulator
AZKH_0487	COG1910	domain protein
AZKH_0488	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AZKH_0492	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AZKH_0493	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AZKH_0494	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AZKH_0495	COG0018	arginyl-trna synthetase
AZKH_0498	COG0300	oxidoreductase activity
AZKH_0500	COG2902	Dehydrogenase
AZKH_0503	COG0826	peptidase U32
AZKH_0504	COG3158	transport of potassium into the cell
AZKH_0505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AZKH_0507	COG3243	poly(R)-hydroxyalkanoic acid synthase
AZKH_0508	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AZKH_0509	COG0789	Transcriptional regulator
AZKH_0511	COG0288	reversible hydration of carbon dioxide
AZKH_0512	COG0183	Belongs to the thiolase family
AZKH_0513	COG1960	acyl-CoA dehydrogenase activity
AZKH_0518	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AZKH_0519	COG1660	Displays ATPase and GTPase activities
AZKH_0522	COG0412	Dienelactone hydrolase
AZKH_0524	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AZKH_0527	COG1301	dicarboxylic acid transport
AZKH_0529	COG1053	succinate dehydrogenase
AZKH_0530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AZKH_0534	COG0217	transcriptional regulatory protein
AZKH_0536	COG0433	COG0433 Predicted ATPase
AZKH_0542	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AZKH_0543	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AZKH_0544	COG1278	Cold shock
AZKH_0545	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AZKH_0548	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AZKH_0550	COG1560	Kdo2-lipid A biosynthetic process
AZKH_0552	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AZKH_0554	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AZKH_0556	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AZKH_0558	COG2255	four-way junction helicase activity
AZKH_0559	COG3284	Transcriptional regulator
AZKH_0561	COG0145	ligase activity
AZKH_0562	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
AZKH_0563	COG4647	ligase activity
AZKH_0565	COG1033	growth of symbiont in host cell
AZKH_0565	COG2409	Drug exporters of the RND superfamily
AZKH_0568	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AZKH_0570	COG0632	four-way junction helicase activity
AZKH_0572	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AZKH_0572	COG0546	phosphoglycolate phosphatase activity
AZKH_0575	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AZKH_0575	COG0392	lysyltransferase activity
AZKH_0578	COG1530	ribonuclease E activity
AZKH_0579	COG0424	maF-like protein
AZKH_0582	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AZKH_0583	COG0799	negative regulation of ribosome biogenesis
AZKH_0584	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AZKH_0587	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AZKH_0591	COG2192	nodulation
AZKH_0592	COG0726	polysaccharide deacetylase
AZKH_0594	COG0438	transferase activity, transferring glycosyl groups
AZKH_0597	COG0438	transferase activity, transferring glycosyl groups
AZKH_0599	COG0438	transferase activity, transferring glycosyl groups
AZKH_0603	COG1132	(ABC) transporter
AZKH_0605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AZKH_0606	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AZKH_0606	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AZKH_0608	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AZKH_0609	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AZKH_0610	COG0745	RESPONSE REGULATOR receiver
AZKH_0610	COG3706	GGDEF domain
AZKH_0614	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AZKH_0616	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AZKH_0616	COG1648	precorrin-2 dehydrogenase activity
AZKH_0618	COG2818	Glycosylase
AZKH_0619	COG0583	DNA-binding transcription factor activity
AZKH_0624	COG0247	lactate metabolic process
AZKH_0627	COG0583	DNA-binding transcription factor activity
AZKH_0628	COG1032	radical SAM domain protein
AZKH_0630	COG0741	lytic transglycosylase activity
AZKH_0631	COG0436	Aminotransferase
AZKH_0632	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AZKH_0633	COG0281	malic enzyme
AZKH_0633	COG0280	phosphate acetyltransferase
AZKH_0635	COG1686	Belongs to the peptidase S11 family
AZKH_0639	COG1187	pseudouridine synthase activity
AZKH_0641	COG0577	efflux transmembrane transporter activity
AZKH_0641	COG1136	(ABC) transporter
AZKH_0643	COG0577	efflux transmembrane transporter activity
AZKH_0643	COG1136	(ABC) transporter
AZKH_0645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AZKH_0646	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AZKH_0647	COG2081	HI0933 family
AZKH_0650	COG1643	Atp-dependent helicase
AZKH_0651	COG0360	Binds together with S18 to 16S ribosomal RNA
AZKH_0652	COG2965	DNA replication, synthesis of RNA primer
AZKH_0653	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AZKH_0654	COG0359	binds to the 23S rRNA
AZKH_0655	COG0305	Participates in initiation and elongation during chromosome replication
AZKH_0661	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AZKH_0662	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AZKH_0666	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AZKH_0667	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
AZKH_0669	COG0237	dephospho-CoA kinase activity
AZKH_0671	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AZKH_0672	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AZKH_0675	COG3852	Histidine kinase
AZKH_0680	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AZKH_0681	COG3568	Endonuclease Exonuclease Phosphatase
AZKH_0682	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AZKH_0685	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AZKH_0687	COG0463	Glycosyl transferase, family 2
AZKH_0690	COG0012	GTP binding
AZKH_0691	COG0193	aminoacyl-tRNA hydrolase activity
AZKH_0692	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AZKH_0693	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AZKH_0695	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AZKH_0696	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AZKH_0698	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AZKH_0699	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AZKH_0700	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AZKH_0701	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AZKH_0702	COG0742	ribosomal rna small subunit methyltransferase
AZKH_0703	COG0612	Peptidase, M16
AZKH_0704	COG0612	Peptidase, M16
AZKH_0706	COG2884	Cell division ATP-binding protein ftsE
AZKH_0707	COG2177	Part of the ABC transporter FtsEX involved in
AZKH_0717	COG0753	catalase activity
AZKH_0719	COG1607	acyl-coa hydrolase
AZKH_0720	COG3622	Belongs to the hyi family
AZKH_0721	COG0587	DNA-directed DNA polymerase activity
AZKH_0722	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AZKH_0724	COG0242	peptide deformylase activity
AZKH_0725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AZKH_0727	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AZKH_0728	COG1702	phosphate starvation-inducible protein PhoH
AZKH_0729	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AZKH_0730	COG4535	Mg2 and Co2 transporter CorC
AZKH_0731	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AZKH_0732	COG0752	glycyl-tRNA synthetase alpha subunit
AZKH_0733	COG0751	glycine-tRNA ligase activity
AZKH_0734	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AZKH_0735	COG0204	Acyl-transferase
AZKH_0739	COG1024	Enoyl-CoA hydratase
AZKH_0740	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AZKH_0744	COG1127	ABC transporter
AZKH_0745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AZKH_0746	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AZKH_0747	COG2853	Lipoprotein
AZKH_0750	COG1131	(ABC) transporter
AZKH_0751	COG0842	Transport permease protein
AZKH_0753	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AZKH_0754	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AZKH_0755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AZKH_0756	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AZKH_0757	COG0131	Imidazoleglycerol-phosphate dehydratase
AZKH_0758	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AZKH_0759	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AZKH_0760	COG0107	imidazoleglycerol-phosphate synthase activity
AZKH_0761	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AZKH_0762	COG0140	phosphoribosyl-ATP diphosphatase activity
AZKH_0763	COG0537	adenosine 5'-monophosphoramidase activity
AZKH_0764	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AZKH_0765	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AZKH_0766	COG0805	protein transport
AZKH_0767	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZKH_0768	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AZKH_0771	COG0045	succinate-CoA ligase (ADP-forming) activity
AZKH_0772	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AZKH_0775	COG3485	protocatechuate 3,4-dioxygenase
AZKH_0779	COG5420	small protein containing a coiled-coil domain
AZKH_0782	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AZKH_0783	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AZKH_0784	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AZKH_0786	COG0306	phosphate transporter
AZKH_0790	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AZKH_0791	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AZKH_0797	COG5554	nitrogen fixation
AZKH_0799	COG3706	GGDEF domain
AZKH_0802	COG0105	UTP biosynthetic process
AZKH_0803	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AZKH_0806	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AZKH_0807	COG0124	histidyl-tRNA synthetase
AZKH_0809	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AZKH_0810	COG1160	GTP binding
AZKH_0811	COG1923	regulation of RNA biosynthetic process
AZKH_0812	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AZKH_0813	COG0330	HflC and HflK could
AZKH_0814	COG0330	HflC and HflK could
AZKH_0816	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AZKH_0817	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AZKH_0820	COG0557	exoribonuclease II activity
AZKH_0821	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AZKH_0822	COG3707	response regulator
AZKH_0824	COG0535	radical SAM domain protein
AZKH_0826	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AZKH_0827	COG0167	dihydroorotate dehydrogenase activity
AZKH_0828	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AZKH_0830	COG1116	anion transmembrane transporter activity
AZKH_0835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AZKH_0837	COG2223	nitrite transmembrane transporter activity
AZKH_0838	COG0515	serine threonine protein kinase
AZKH_0838	COG2815	serine threonine protein kinase
AZKH_0839	COG0243	molybdopterin cofactor binding
AZKH_0842	COG5001	Diguanylate cyclase
AZKH_0844	COG0840	transmembrane signaling receptor activity
AZKH_0847	COG2198	Histidine kinase
AZKH_0847	COG0643	Histidine kinase
AZKH_0848	COG0840	transmembrane signaling receptor activity
AZKH_0849	COG0835	chemotaxis
AZKH_0851	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AZKH_0852	COG1752	Esterase of the alpha-beta hydrolase superfamily
AZKH_0853	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AZKH_0854	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AZKH_0855	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AZKH_0856	COG0723	plastoquinol--plastocyanin reductase activity
AZKH_0857	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AZKH_0858	COG2857	Cytochrome c1
AZKH_0859	COG0625	glutathione transferase activity
AZKH_0860	COG2969	positive regulation of protein catabolic process
AZKH_0861	COG0438	transferase activity, transferring glycosyl groups
AZKH_0862	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AZKH_0863	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AZKH_0865	COG0506	proline dehydrogenase activity
AZKH_0865	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AZKH_0865	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AZKH_0870	COG1595	DNA-templated transcription, initiation
AZKH_0872	COG0625	glutathione transferase activity
AZKH_0873	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AZKH_0874	COG0459	protein refolding
AZKH_0875	COG0745	RESPONSE REGULATOR receiver
AZKH_0876	COG0642	Histidine kinase
AZKH_0877	COG3162	membrane
AZKH_0880	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AZKH_0881	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AZKH_0882	COG2890	protein-(glutamine-N5) methyltransferase activity
AZKH_0883	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AZKH_0888	COG0165	Argininosuccinate lyase
AZKH_0890	COG1596	polysaccharide export
AZKH_0893	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AZKH_0895	COG0489	protein tyrosine kinase activity
AZKH_0895	COG3206	protein involved in exopolysaccharide biosynthesis
AZKH_0896	COG0297	glycogen (starch) synthase activity
AZKH_0899	COG1086	Polysaccharide biosynthesis protein
AZKH_0903	COG0438	transferase activity, transferring glycosyl groups
AZKH_0907	COG0438	transferase activity, transferring glycosyl groups
AZKH_0908	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AZKH_0911	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AZKH_0912	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AZKH_0913	COG0181	hydroxymethylbilane synthase activity
AZKH_0915	COG2959	enzyme of heme biosynthesis
AZKH_0917	COG0408	coproporphyrinogen oxidase activity
AZKH_0918	COG0151	Belongs to the GarS family
AZKH_0919	COG0138	bifunctional purine biosynthesis protein purh
AZKH_0920	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AZKH_0921	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AZKH_0922	COG0745	RESPONSE REGULATOR receiver
AZKH_0922	COG3706	GGDEF domain
AZKH_0923	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AZKH_0924	COG0006	proline dipeptidase activity
AZKH_0927	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AZKH_0928	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AZKH_0929	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AZKH_0930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AZKH_0932	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AZKH_0934	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AZKH_0940	COG0489	protein tyrosine kinase activity
AZKH_0941	COG0463	Glycosyl transferase, family 2
AZKH_0941	COG1216	Glycosyl transferase, family 2
AZKH_0947	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AZKH_0950	COG0438	transferase activity, transferring glycosyl groups
AZKH_0951	COG2244	polysaccharide biosynthetic process
AZKH_0952	COG2327	Polysaccharide pyruvyl transferase
AZKH_0953	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AZKH_0963	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AZKH_0965	COG3047	cAMP biosynthetic process
AZKH_0965	COG2885	chlorophyll binding
AZKH_0966	COG5001	Diguanylate cyclase
AZKH_0966	COG5002	protein histidine kinase activity
AZKH_0968	COG0745	RESPONSE REGULATOR receiver
AZKH_0968	COG3706	GGDEF domain
AZKH_0971	COG0778	Nitroreductase
AZKH_0972	COG0469	pyruvate kinase activity
AZKH_0975	COG0126	phosphoglycerate kinase activity
AZKH_0976	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AZKH_0977	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AZKH_0978	COG3954	Phosphoribulokinase
AZKH_0981	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AZKH_0983	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AZKH_0983	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AZKH_0985	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AZKH_0986	COG0704	Plays a role in the regulation of phosphate uptake
AZKH_0987	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AZKH_0988	COG0303	'Molybdopterin
AZKH_0990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AZKH_0993	COG2226	methyltransferase
AZKH_0994	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AZKH_0995	COG1040	competence protein
AZKH_0996	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AZKH_0997	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AZKH_0999	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AZKH_1001	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AZKH_1002	COG0640	Transcriptional regulator
AZKH_1004	COG0793	Belongs to the peptidase S41A family
AZKH_1006	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AZKH_1007	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AZKH_1007	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AZKH_1008	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AZKH_1009	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AZKH_1010	COG0406	alpha-ribazole phosphatase activity
AZKH_1012	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AZKH_1013	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
AZKH_1014	COG0312	modulator of DNA gyrase
AZKH_1015	COG3028	Belongs to the UPF0307 family
AZKH_1016	COG0521	Mo-molybdopterin cofactor biosynthetic process
AZKH_1017	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AZKH_1018	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AZKH_1022	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AZKH_1024	COG2096	Adenosyltransferase
AZKH_1025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AZKH_1033	COG0482	sulfurtransferase activity
AZKH_1038	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AZKH_1040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AZKH_1041	COG0312	modulator of DNA gyrase
AZKH_1042	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AZKH_1043	COG2204	response regulator
AZKH_1047	COG0442	prolyl-tRNA aminoacylation
AZKH_1048	COG0494	nUDIX hydrolase
AZKH_1050	COG1592	Rubrerythrin
AZKH_1051	COG0247	lactate metabolic process
AZKH_1054	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AZKH_1055	COG1765	OsmC-like protein
AZKH_1056	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AZKH_1057	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AZKH_1058	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AZKH_1059	COG0316	Belongs to the HesB IscA family
AZKH_1061	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AZKH_1069	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AZKH_1070	COG3290	protein histidine kinase activity
AZKH_1071	COG2204	response regulator
AZKH_1075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZKH_1079	COG1704	LemA family
AZKH_1081	COG0604	alcohol dehydrogenase
AZKH_1083	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AZKH_1085	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AZKH_1092	COG1819	glycosyl
AZKH_1093	COG0741	lytic transglycosylase activity
AZKH_1094	COG2165	general secretion pathway protein
AZKH_1106	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AZKH_1107	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AZKH_1108	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AZKH_1109	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AZKH_1111	COG0277	FAD linked oxidase domain protein
AZKH_1113	COG0277	FAD linked oxidase domain protein
AZKH_1114	COG0247	lactate metabolic process
AZKH_1116	COG0631	protein serine/threonine phosphatase activity
AZKH_1117	COG0598	Magnesium transport protein CorA
AZKH_1118	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AZKH_1119	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
AZKH_1120	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
AZKH_1123	COG0513	Belongs to the DEAD box helicase family
AZKH_1124	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AZKH_1126	COG1653	transport
AZKH_1127	COG0584	glycerophosphoryl diester phosphodiesterase
AZKH_1128	COG0142	geranyltranstransferase activity
AZKH_1133	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AZKH_1137	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AZKH_1148	COG0714	Associated with various cellular activities
AZKH_1154	COG1484	DNA-dependent DNA replication
AZKH_1159	COG2815	serine threonine protein kinase
AZKH_1159	COG0515	serine threonine protein kinase
AZKH_1161	COG1196	nuclear chromosome segregation
AZKH_1166	COG1201	RNA secondary structure unwinding
AZKH_1173	COG2030	dehydratase
AZKH_1184	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AZKH_1186	COG1469	GTP cyclohydrolase I activity
AZKH_1187	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AZKH_1188	COG0142	geranyltranstransferase activity
AZKH_1189	COG1722	exodeoxyribonuclease VII activity
AZKH_1191	COG5002	protein histidine kinase activity
AZKH_1193	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AZKH_1194	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AZKH_1195	COG1047	Peptidyl-prolyl cis-trans
AZKH_1196	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AZKH_1197	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AZKH_1198	COG0196	riboflavin kinase activity
AZKH_1199	COG0860	N-Acetylmuramoyl-L-alanine amidase
AZKH_1200	COG0802	atpase or kinase
AZKH_1202	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AZKH_1205	COG0697	spore germination
AZKH_1206	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AZKH_1207	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AZKH_1210	COG0583	DNA-binding transcription factor activity
AZKH_1211	COG2205	protein histidine kinase activity
AZKH_1212	COG0745	RESPONSE REGULATOR receiver
AZKH_1214	COG2224	Isocitrate lyase
AZKH_1215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AZKH_1216	COG0542	response to heat
AZKH_1217	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AZKH_1218	COG1278	Cold shock
AZKH_1219	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AZKH_1220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AZKH_1221	COG2003	Belongs to the UPF0758 family
AZKH_1222	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AZKH_1223	COG0756	dUTP diphosphatase activity
AZKH_1225	COG0446	pyridine nucleotide-disulphide oxidoreductase
AZKH_1229	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AZKH_1231	COG0538	isocitrate dehydrogenase activity
AZKH_1232	COG3047	cAMP biosynthetic process
AZKH_1238	COG4206	TonB-dependent receptor
AZKH_1241	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AZKH_1242	COG0730	response to heat
AZKH_1244	COG0583	DNA-binding transcription factor activity
AZKH_1247	COG2308	Evidence 4 Homologs of previously reported genes of
AZKH_1256	COG3501	Rhs element vgr protein
AZKH_1259	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AZKH_1262	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AZKH_1263	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AZKH_1264	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AZKH_1267	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AZKH_1268	COG4974	Belongs to the 'phage' integrase family
AZKH_1269	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AZKH_1271	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AZKH_1272	COG1466	dna polymerase III delta subunit
AZKH_1273	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
AZKH_1274	COG0495	leucyl-tRNA aminoacylation
AZKH_1276	COG0210	DNA helicase
AZKH_1277	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AZKH_1278	COG0281	malic enzyme
AZKH_1278	COG0280	phosphate acetyltransferase
AZKH_1283	COG0450	alkyl hydroperoxide reductase
AZKH_1284	COG0840	transmembrane signaling receptor activity
AZKH_1288	COG1254	Belongs to the acylphosphatase family
AZKH_1289	COG0659	secondary active sulfate transmembrane transporter activity
AZKH_1290	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AZKH_1290	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AZKH_1293	COG0717	Belongs to the dCTP deaminase family
AZKH_1294	COG1982	Orn Lys Arg decarboxylase major
AZKH_1296	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AZKH_1306	COG1815	bacterial-type flagellum-dependent cell motility
AZKH_1307	COG1558	bacterial-type flagellum-dependent cell motility
AZKH_1308	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AZKH_1309	COG1749	Flagellar hook protein flgE
AZKH_1311	COG4786	Flagellar basal body rod
AZKH_1312	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AZKH_1313	COG1706	bacterial-type flagellum-dependent cell motility
AZKH_1314	COG1705	Flagellar rod assembly protein muramidase FlgJ
AZKH_1314	COG3951	Flagellar rod assembly protein muramidase FlgJ
AZKH_1315	COG1256	bacterial-type flagellum assembly
AZKH_1316	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AZKH_1319	COG1987	bacterial-type flagellum assembly
AZKH_1320	COG1338	Plays a role in the flagellum-specific transport system
AZKH_1323	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AZKH_1327	COG1157	protein secretion by the type III secretion system
AZKH_1329	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AZKH_1331	COG3852	Histidine kinase
AZKH_1333	COG1677	Flagellar hook-basal body complex protein FliE
AZKH_1334	COG0582	viral genome integration into host DNA
AZKH_1345	COG1074	ATP-dependent DNA helicase activity
AZKH_1349	COG1397	ADP-ribosylglycohydrolase
AZKH_1351	COG2176	DNA-directed DNA polymerase activity
AZKH_1363	COG0776	regulation of translation
AZKH_1380	COG0542	response to heat
AZKH_1382	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AZKH_1382	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AZKH_1398	COG0758	DNA mediated transformation
AZKH_1400	COG0629	single-stranded DNA binding
AZKH_1407	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AZKH_1408	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AZKH_1422	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AZKH_1427	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AZKH_1429	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AZKH_1430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AZKH_1433	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AZKH_1438	COG0028	Belongs to the TPP enzyme family
AZKH_1443	COG3706	GGDEF domain
AZKH_1445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AZKH_1446	COG0508	dehydrogenase complex catalyzes the overall conversion of
AZKH_1447	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AZKH_1450	COG4566	intracellular signal transduction
AZKH_1452	COG0840	transmembrane signaling receptor activity
AZKH_1455	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AZKH_1456	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AZKH_1457	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AZKH_1458	COG0009	L-threonylcarbamoyladenylate synthase
AZKH_1460	COG4691	Plasmid stability protein
AZKH_1468	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
AZKH_1470	COG4453	Protein conserved in bacteria
AZKH_1475	COG0288	reversible hydration of carbon dioxide
AZKH_1476	COG0583	DNA-binding transcription factor activity
AZKH_1477	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AZKH_1478	COG0861	Integral membrane protein TerC family
AZKH_1479	COG0628	permease
AZKH_1480	COG3260	NADH ubiquinone oxidoreductase 20
AZKH_1481	COG0649	NAD binding
AZKH_1482	COG0651	ATP synthesis coupled electron transport
AZKH_1484	COG0650	Formate hydrogenlyase subunit 4
AZKH_1485	COG0651	ATP synthesis coupled electron transport
AZKH_1490	COG3876	Protein conserved in bacteria
AZKH_1492	COG1796	DNA polymerase
AZKH_1492	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AZKH_1493	COG0459	protein refolding
AZKH_1496	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AZKH_1499	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_1502	COG0484	heat shock protein binding
AZKH_1504	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AZKH_1505	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AZKH_1506	COG0022	dehydrogenase e1 component
AZKH_1506	COG0508	dehydrogenase complex catalyzes the overall conversion of
AZKH_1507	COG0508	dehydrogenase complex catalyzes the overall conversion of
AZKH_1508	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AZKH_1510	COG0583	DNA-binding transcription factor activity
AZKH_1515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZKH_1519	COG4772	TonB-dependent receptor
AZKH_1520	COG2814	Major facilitator Superfamily
AZKH_1521	COG1566	PFAM secretion protein HlyD family protein
AZKH_1523	COG1846	Transcriptional regulator
AZKH_1525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AZKH_1528	COG2885	chlorophyll binding
AZKH_1535	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AZKH_1536	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AZKH_1538	COG0535	radical SAM domain protein
AZKH_1543	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AZKH_1549	COG2197	response regulator
AZKH_1550	COG0386	Belongs to the glutathione peroxidase family
AZKH_1551	COG1403	HNH endonuclease
AZKH_1552	COG0655	NAD(P)H dehydrogenase (quinone) activity
AZKH_1554	COG3851	Histidine kinase
AZKH_1563	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZKH_1564	COG4215	(ABC) transporter
AZKH_1570	COG2095	MarC family integral membrane protein
AZKH_1571	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AZKH_1573	COG1509	lysine 2,3-aminomutase activity
AZKH_1574	COG0604	alcohol dehydrogenase
AZKH_1576	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AZKH_1577	COG5012	cobalamin binding
AZKH_1578	COG1607	acyl-coa hydrolase
AZKH_1579	COG3246	L-lysine catabolic process to acetate
AZKH_1580	COG4191	Histidine kinase
AZKH_1585	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
AZKH_1593	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AZKH_1594	COG0589	response to stress
AZKH_1595	COG1802	Transcriptional regulator
AZKH_1601	COG0784	Response regulator, receiver
AZKH_1601	COG2205	protein histidine kinase activity
AZKH_1602	COG3284	Transcriptional regulator
AZKH_1603	COG1012	belongs to the aldehyde dehydrogenase family
AZKH_1605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AZKH_1608	COG1131	(ABC) transporter
AZKH_1614	COG3284	Transcriptional regulator
AZKH_1616	COG2414	aldehyde ferredoxin oxidoreductase
AZKH_1617	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AZKH_1621	COG0840	transmembrane signaling receptor activity
AZKH_1623	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AZKH_1624	COG0583	DNA-binding transcription factor activity
AZKH_1626	COG3038	cytochrome b561
AZKH_1627	COG2353	YceI-like domain
AZKH_1628	COG2353	YceI-like domain
AZKH_1639	COG0315	cyclic pyranopterin monophosphate synthase activity
AZKH_1640	COG4783	chaperone-mediated protein folding
AZKH_1641	COG0425	Belongs to the sulfur carrier protein TusA family
AZKH_1642	COG0525	valine-tRNA ligase activity
AZKH_1645	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AZKH_1646	COG0795	lipopolysaccharide-transporting ATPase activity
AZKH_1650	COG1959	2 iron, 2 sulfur cluster binding
AZKH_1651	COG0840	transmembrane signaling receptor activity
AZKH_1653	COG2814	Major facilitator Superfamily
AZKH_1654	COG0583	DNA-binding transcription factor activity
AZKH_1659	COG4585	Histidine kinase
AZKH_1659	COG2203	Gaf domain
AZKH_1661	COG0745	RESPONSE REGULATOR receiver
AZKH_1662	COG2205	protein histidine kinase activity
AZKH_1663	COG0443	Heat shock 70 kDa protein
AZKH_1664	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AZKH_1665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AZKH_1666	COG3474	cytochrome
AZKH_1669	COG1136	(ABC) transporter
AZKH_1674	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AZKH_1674	COG0674	pyruvate-flavodoxin oxidoreductase activity
AZKH_1675	COG1013	pyruvate-flavodoxin oxidoreductase activity
AZKH_1678	COG3706	GGDEF domain
AZKH_1678	COG0745	RESPONSE REGULATOR receiver
AZKH_1679	COG5002	protein histidine kinase activity
AZKH_1679	COG0784	Response regulator, receiver
AZKH_1679	COG2205	protein histidine kinase activity
AZKH_1683	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AZKH_1684	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AZKH_1693	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AZKH_1695	COG0582	viral genome integration into host DNA
AZKH_1713	COG3256	nitric oxide reductase
AZKH_1714	COG2010	Cytochrome c
AZKH_1719	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AZKH_1721	COG5002	protein histidine kinase activity
AZKH_1722	COG0745	RESPONSE REGULATOR receiver
AZKH_1723	COG2176	DNA-directed DNA polymerase activity
AZKH_1723	COG5002	protein histidine kinase activity
AZKH_1724	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AZKH_1728	COG3265	gluconokinase activity
AZKH_1729	COG1609	Transcriptional regulator
AZKH_1731	COG4221	oxidoreductase activity
AZKH_1734	COG4251	negative regulation of phosphorylation
AZKH_1734	COG3706	GGDEF domain
AZKH_1734	COG5001	Diguanylate cyclase
AZKH_1734	COG2203	Gaf domain
AZKH_1736	COG1960	acyl-CoA dehydrogenase activity
AZKH_1738	COG0179	Fumarylacetoacetate (FAA) hydrolase
AZKH_1741	COG2271	Major facilitator Superfamily
AZKH_1768	COG0045	succinate-CoA ligase (ADP-forming) activity
AZKH_1768	COG1042	CoA-binding domain protein
AZKH_1768	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AZKH_1773	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_1776	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AZKH_1781	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AZKH_1786	COG0326	Molecular chaperone. Has ATPase activity
AZKH_1794	COG3706	GGDEF domain
AZKH_1794	COG0745	RESPONSE REGULATOR receiver
AZKH_1795	COG4191	Histidine kinase
AZKH_1797	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AZKH_1801	COG4656	Part of a membrane complex involved in electron transport
AZKH_1802	COG2878	Part of a membrane complex involved in electron transport
AZKH_1803	COG4657	Part of a membrane complex involved in electron transport
AZKH_1804	COG0167	dihydroorotate dehydrogenase activity
AZKH_1805	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AZKH_1806	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AZKH_1807	COG3842	ATPase activity
AZKH_1808	COG1178	ABC-type Fe3 transport system permease component
AZKH_1811	COG1840	ABC-type Fe3 transport system, periplasmic component
AZKH_1814	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AZKH_1816	COG0039	L-malate dehydrogenase activity
AZKH_1817	COG2188	Transcriptional regulator
AZKH_1820	COG1053	succinate dehydrogenase
AZKH_1821	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AZKH_1822	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AZKH_1823	COG0372	Belongs to the citrate synthase family
AZKH_1824	COG0567	Dehydrogenase, E1 component
AZKH_1825	COG0508	dehydrogenase complex catalyzes the overall conversion of
AZKH_1826	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AZKH_1827	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AZKH_1828	COG1199	ATP-dependent helicase activity
AZKH_1831	COG1763	Mo-molybdopterin cofactor biosynthetic process
AZKH_1832	COG0303	'Molybdopterin
AZKH_1833	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AZKH_1834	COG0314	molybdopterin synthase activity
AZKH_1836	COG0542	response to heat
AZKH_1837	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AZKH_1840	COG0601	transmembrane transport
AZKH_1841	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AZKH_1842	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AZKH_1843	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AZKH_1844	COG2867	negative regulation of translational initiation
AZKH_1845	COG2914	Belongs to the UPF0125 (RnfH) family
AZKH_1848	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AZKH_1848	COG0519	Catalyzes the synthesis of GMP from XMP
AZKH_1851	COG2814	Major facilitator Superfamily
AZKH_1854	COG2086	electron transfer activity
AZKH_1855	COG0183	Belongs to the thiolase family
AZKH_1856	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_1857	COG1024	Enoyl-CoA hydratase
AZKH_1860	COG1960	acyl-CoA dehydrogenase activity
AZKH_1861	COG1024	Enoyl-CoA hydratase
AZKH_1862	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_1869	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AZKH_1871	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
AZKH_1877	COG2409	Drug exporters of the RND superfamily
AZKH_1881	COG3474	cytochrome
AZKH_1893	COG1960	acyl-CoA dehydrogenase activity
AZKH_1894	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_1895	COG3268	Saccharopine dehydrogenase
AZKH_1909	COG0765	amino acid transport
AZKH_1910	COG1126	abc transporter atp-binding protein
AZKH_1913	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AZKH_1916	COG0583	DNA-binding transcription factor activity
AZKH_1917	COG2828	Protein conserved in bacteria
AZKH_1921	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
AZKH_1925	COG0583	DNA-binding transcription factor activity
AZKH_1926	COG1053	succinate dehydrogenase
AZKH_1928	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AZKH_1929	COG2828	Protein conserved in bacteria
AZKH_1930	COG4221	oxidoreductase activity
AZKH_1930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AZKH_1930	COG3321	synthase
AZKH_1930	COG0300	oxidoreductase activity
AZKH_1931	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_1933	COG1960	acyl-CoA dehydrogenase activity
AZKH_1934	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_1935	COG3246	L-lysine catabolic process to acetate
AZKH_1939	COG2197	response regulator
AZKH_1945	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_1947	COG2197	response regulator
AZKH_1950	COG0641	radical SAM
AZKH_1952	COG0596	Alpha beta hydrolase
AZKH_1954	COG0028	Belongs to the TPP enzyme family
AZKH_1958	COG1063	alcohol dehydrogenase
AZKH_1960	COG1012	belongs to the aldehyde dehydrogenase family
AZKH_1969	COG2271	Major facilitator Superfamily
AZKH_1970	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_1971	COG1882	Formate acetyltransferase
AZKH_1972	COG2855	membrane
AZKH_1976	COG2175	clavaminate synthase activity
AZKH_1984	COG0300	oxidoreductase activity
AZKH_1986	COG1024	Enoyl-CoA hydratase
AZKH_1989	COG2249	NAD(P)H dehydrogenase (quinone) activity
AZKH_1990	COG4251	negative regulation of phosphorylation
AZKH_1990	COG5001	Diguanylate cyclase
AZKH_1990	COG3706	GGDEF domain
AZKH_1990	COG2203	Gaf domain
AZKH_1993	COG0583	DNA-binding transcription factor activity
AZKH_1995	COG0628	permease
AZKH_2003	COG3459	Glycosyltransferase 36 associated
AZKH_2006	COG0628	permease
AZKH_2018	COG2204	response regulator
AZKH_2019	COG2610	gluconate transmembrane transporter activity
AZKH_2021	COG1196	nuclear chromosome segregation
AZKH_2024	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AZKH_2030	COG1620	l-lactate permease
AZKH_2032	COG1136	(ABC) transporter
AZKH_2037	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AZKH_2041	COG0583	DNA-binding transcription factor activity
AZKH_2042	COG1902	pentaerythritol trinitrate reductase activity
AZKH_2042	COG0446	pyridine nucleotide-disulphide oxidoreductase
AZKH_2045	COG0463	Glycosyl transferase, family 2
AZKH_2047	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AZKH_2047	COG0047	phosphoribosylformylglycinamidine synthase activity
AZKH_2054	COG0824	Thioesterase
AZKH_2056	COG0504	CTP synthase activity
AZKH_2057	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AZKH_2058	COG0148	phosphopyruvate hydratase activity
AZKH_2059	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AZKH_2061	COG0791	NLP P60 protein
AZKH_2065	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AZKH_2066	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AZKH_2069	COG0302	gtp cyclohydrolase
AZKH_2071	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AZKH_2075	COG4681	YaeQ
AZKH_2077	COG1253	flavin adenine dinucleotide binding
AZKH_2078	COG1012	belongs to the aldehyde dehydrogenase family
AZKH_2081	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AZKH_2082	COG3360	Dodecin
AZKH_2083	COG0477	Major facilitator Superfamily
AZKH_2084	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AZKH_2088	COG0523	cobalamin synthesis protein
AZKH_2089	COG2879	small protein
AZKH_2090	COG1966	Carbon starvation protein
AZKH_2093	COG5002	protein histidine kinase activity
AZKH_2093	COG0784	Response regulator, receiver
AZKH_2093	COG2198	Histidine kinase
AZKH_2094	COG2205	protein histidine kinase activity
AZKH_2094	COG2202	Pas domain
AZKH_2096	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZKH_2096	COG2205	protein histidine kinase activity
AZKH_2098	COG3706	GGDEF domain
AZKH_2098	COG0745	RESPONSE REGULATOR receiver
AZKH_2101	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AZKH_2103	COG0840	transmembrane signaling receptor activity
AZKH_2104	COG0835	chemotaxis
AZKH_2105	COG2198	Histidine kinase
AZKH_2105	COG0643	Histidine kinase
AZKH_2106	COG0745	RESPONSE REGULATOR receiver
AZKH_2110	COG0410	ABC transporter
AZKH_2120	COG4206	TonB-dependent receptor
AZKH_2122	COG3300	MHYT domain
AZKH_2122	COG5001	Diguanylate cyclase
AZKH_2123	COG2133	pyrroloquinoline quinone binding
AZKH_2132	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AZKH_2136	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AZKH_2149	COG1024	Enoyl-CoA hydratase
AZKH_2150	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_2155	COG0411	ABC transporter
AZKH_2159	COG2197	response regulator
AZKH_2162	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_2163	COG1024	Enoyl-CoA hydratase
AZKH_2164	COG0183	Belongs to the thiolase family
AZKH_2166	COG1960	acyl-CoA dehydrogenase activity
AZKH_2167	COG2816	NAD+ diphosphatase activity
AZKH_2172	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AZKH_2172	COG0515	serine threonine protein kinase
AZKH_2177	COG3437	response regulator, receiver
AZKH_2178	COG1538	Outer membrane efflux protein
AZKH_2180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AZKH_2181	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AZKH_2183	COG2204	response regulator
AZKH_2189	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AZKH_2196	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AZKH_2197	COG3706	GGDEF domain
AZKH_2200	COG2197	response regulator
AZKH_2202	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AZKH_2202	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AZKH_2203	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AZKH_2205	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AZKH_2207	COG0850	regulation of cytokinetic process
AZKH_2208	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AZKH_2209	COG1393	Belongs to the ArsC family
AZKH_2210	COG2183	response to ionizing radiation
AZKH_2211	COG0676	glucose-6-phosphate 1-epimerase activity
AZKH_2212	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AZKH_2212	COG0045	succinate-CoA ligase (ADP-forming) activity
AZKH_2212	COG1042	CoA-binding domain protein
AZKH_2214	COG3852	Histidine kinase
AZKH_2216	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AZKH_2219	COG4181	ATPase activity
AZKH_2220	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AZKH_2221	COG1562	ergosterol biosynthetic process
AZKH_2222	COG1562	ergosterol biosynthetic process
AZKH_2223	COG3447	MASE1 domain protein
AZKH_2223	COG5002	protein histidine kinase activity
AZKH_2223	COG5001	Diguanylate cyclase
AZKH_2225	COG1136	(ABC) transporter
AZKH_2229	COG3263	regulation of cellular component size
AZKH_2230	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AZKH_2231	COG0488	(ABC) transporter
AZKH_2233	COG0508	dehydrogenase complex catalyzes the overall conversion of
AZKH_2235	COG1215	transferase activity, transferring glycosyl groups
AZKH_2238	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AZKH_2238	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AZKH_2239	COG0509	glycine decarboxylation via glycine cleavage system
AZKH_2240	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AZKH_2241	COG0613	PHP domain protein
AZKH_2243	COG0009	L-threonylcarbamoyladenylate synthase
AZKH_2244	COG1994	Peptidase M50
AZKH_2245	COG0180	Tryptophanyl-tRNA synthetase
AZKH_2246	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AZKH_2247	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AZKH_2249	COG0779	Required for maturation of 30S ribosomal subunits
AZKH_2250	COG0195	Participates in both transcription termination and antitermination
AZKH_2250	COG2251	uridine kinase activity
AZKH_2251	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AZKH_2252	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AZKH_2253	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AZKH_2254	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AZKH_2255	COG1185	polyribonucleotide nucleotidyltransferase activity
AZKH_2256	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AZKH_2261	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_2263	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_2267	COG2130	NADP-dependent
AZKH_2270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AZKH_2271	COG0022	dehydrogenase e1 component
AZKH_2273	COG0508	dehydrogenase complex catalyzes the overall conversion of
AZKH_2274	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_2277	COG0183	Belongs to the thiolase family
AZKH_2278	COG4638	Rieske (2fe-2S)
AZKH_2279	COG2130	NADP-dependent
AZKH_2280	COG1960	acyl-CoA dehydrogenase activity
AZKH_2281	COG1960	acyl-CoA dehydrogenase activity
AZKH_2282	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_2284	COG0183	Belongs to the thiolase family
AZKH_2285	COG1024	Enoyl-CoA hydratase
AZKH_2289	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_2291	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_2296	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_2299	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_2306	COG1960	acyl-CoA dehydrogenase activity
AZKH_2307	COG1960	acyl-CoA dehydrogenase activity
AZKH_2308	COG2814	Major facilitator Superfamily
AZKH_2319	COG1053	succinate dehydrogenase
AZKH_2320	COG2814	Major facilitator Superfamily
AZKH_2324	COG4974	Belongs to the 'phage' integrase family
AZKH_2332	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_2333	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_2335	COG1024	Enoyl-CoA hydratase
AZKH_2336	COG0183	Belongs to the thiolase family
AZKH_2337	COG1024	Enoyl-CoA hydratase
AZKH_2337	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_2338	COG2130	NADP-dependent
AZKH_2341	COG1960	acyl-CoA dehydrogenase activity
AZKH_2342	COG1960	acyl-CoA dehydrogenase activity
AZKH_2343	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_2345	COG2814	Major facilitator Superfamily
AZKH_2346	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_2348	COG0183	Belongs to the thiolase family
AZKH_2350	COG0183	Belongs to the thiolase family
AZKH_2351	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_2352	COG1960	acyl-CoA dehydrogenase activity
AZKH_2355	COG0588	phosphoglycerate mutase activity
AZKH_2357	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AZKH_2364	COG0488	(ABC) transporter
AZKH_2366	COG1053	succinate dehydrogenase
AZKH_2366	COG3976	FMN-binding domain protein
AZKH_2373	COG2151	metal-sulfur cluster biosynthetic enzyme
AZKH_2375	COG2862	Uncharacterized protein family, UPF0114
AZKH_2376	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AZKH_2377	COG0024	Methionine aminopeptidase
AZKH_2378	COG0052	Belongs to the universal ribosomal protein uS2 family
AZKH_2379	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AZKH_2380	COG0528	UMP kinase activity
AZKH_2381	COG0233	cytoplasmic translational termination
AZKH_2382	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AZKH_2383	COG0575	Belongs to the CDS family
AZKH_2384	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AZKH_2388	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AZKH_2389	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AZKH_2390	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AZKH_2391	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AZKH_2392	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AZKH_2394	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AZKH_2395	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AZKH_2396	COG2226	methyltransferase
AZKH_2397	COG2267	carboxylic ester hydrolase activity
AZKH_2398	COG0156	8-amino-7-oxononanoate synthase activity
AZKH_2400	COG3022	response to hydroperoxide
AZKH_2401	COG2866	Carboxypeptidase
AZKH_2402	COG0560	Phosphoserine phosphatase
AZKH_2403	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AZKH_2415	COG4263	nitrous-oxide reductase activity
AZKH_2424	COG3706	GGDEF domain
AZKH_2425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZKH_2426	COG0534	Mate efflux family protein
AZKH_2427	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AZKH_2428	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AZKH_2431	COG0741	lytic transglycosylase activity
AZKH_2431	COG1388	LysM domain
AZKH_2432	COG2203	Gaf domain
AZKH_2432	COG3706	GGDEF domain
AZKH_2432	COG4251	negative regulation of phosphorylation
AZKH_2432	COG5001	Diguanylate cyclase
AZKH_2433	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AZKH_2434	COG2226	methyltransferase
AZKH_2435	COG0328	RNA-DNA hybrid ribonuclease activity
AZKH_2436	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AZKH_2438	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AZKH_2441	COG2353	YceI-like domain
AZKH_2445	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AZKH_2447	COG4208	sulfate ABC transporter
AZKH_2448	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AZKH_2452	COG0666	response to abiotic stimulus
AZKH_2453	COG1024	Enoyl-CoA hydratase
AZKH_2456	COG0477	Major facilitator Superfamily
AZKH_2457	COG4191	Histidine kinase
AZKH_2471	COG5001	Diguanylate cyclase
AZKH_2472	COG1309	transcriptional regulator
AZKH_2475	COG1271	oxidase subunit
AZKH_2476	COG1294	oxidase, subunit
AZKH_2478	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AZKH_2483	COG2144	transferase activity, transferring acyl groups
AZKH_2484	COG0438	transferase activity, transferring glycosyl groups
AZKH_2488	COG5001	Diguanylate cyclase
AZKH_2488	COG4251	negative regulation of phosphorylation
AZKH_2488	COG3706	GGDEF domain
AZKH_2488	COG2203	Gaf domain
AZKH_2489	COG0446	pyridine nucleotide-disulphide oxidoreductase
AZKH_2489	COG1902	pentaerythritol trinitrate reductase activity
AZKH_2498	COG1960	acyl-CoA dehydrogenase activity
AZKH_2500	COG2909	trisaccharide binding
AZKH_2503	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_2504	COG1960	acyl-CoA dehydrogenase activity
AZKH_2505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AZKH_2506	COG4770	biotin carboxylase activity
AZKH_2507	COG0439	Biotin carboxylase
AZKH_2509	COG1024	Enoyl-CoA hydratase
AZKH_2512	COG2226	methyltransferase
AZKH_2513	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AZKH_2514	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_2514	COG1024	Enoyl-CoA hydratase
AZKH_2515	COG0183	Belongs to the thiolase family
AZKH_2519	COG4585	Histidine kinase
AZKH_2520	COG2197	response regulator
AZKH_2522	COG1335	isochorismatase
AZKH_2524	COG1228	amidohydrolase
AZKH_2527	COG0473	3-isopropylmalate dehydrogenase activity
AZKH_2528	COG1522	sequence-specific DNA binding
AZKH_2532	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AZKH_2534	COG1012	belongs to the aldehyde dehydrogenase family
AZKH_2536	COG0129	dihydroxy-acid dehydratase activity
AZKH_2537	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AZKH_2539	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AZKH_2541	COG0601	transmembrane transport
AZKH_2542	COG4171	peptide transport system, permease
AZKH_2546	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AZKH_2550	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AZKH_2558	COG5001	Diguanylate cyclase
AZKH_2558	COG3300	MHYT domain
AZKH_2559	COG1741	Belongs to the pirin family
AZKH_2561	COG0564	pseudouridine synthase activity
AZKH_2562	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AZKH_2563	COG0066	3-isopropylmalate dehydratase activity
AZKH_2568	COG4650	regulator
AZKH_2570	COG1690	Belongs to the RtcB family
AZKH_2571	COG0643	Histidine kinase
AZKH_2571	COG2198	Histidine kinase
AZKH_2572	COG2201	protein-glutamate methylesterase activity
AZKH_2574	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_2576	COG1611	Belongs to the LOG family
AZKH_2579	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AZKH_2582	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_2587	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AZKH_2593	COG0531	amino acid
AZKH_2597	COG0583	DNA-binding transcription factor activity
AZKH_2600	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AZKH_2601	COG0697	spore germination
AZKH_2607	COG4521	taurine ABC transporter
AZKH_2609	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AZKH_2610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AZKH_2612	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AZKH_2613	COG1012	belongs to the aldehyde dehydrogenase family
AZKH_2614	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_2616	COG3835	regulator
AZKH_2620	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AZKH_2623	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AZKH_2623	COG0723	plastoquinol--plastocyanin reductase activity
AZKH_2627	COG2205	protein histidine kinase activity
AZKH_2629	COG0297	glycogen (starch) synthase activity
AZKH_2630	COG1640	4-alpha-glucanotransferase
AZKH_2631	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AZKH_2632	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AZKH_2635	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AZKH_2637	COG0438	transferase activity, transferring glycosyl groups
AZKH_2641	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AZKH_2644	COG1294	oxidase, subunit
AZKH_2645	COG1271	oxidase subunit
AZKH_2648	COG5487	UPF0391 membrane protein
AZKH_2649	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZKH_2663	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_2666	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AZKH_2669	COG3530	Putative quorum-sensing-regulated virulence factor
AZKH_2670	COG2195	Cleaves the N-terminal amino acid of tripeptides
AZKH_2674	COG3842	ATPase activity
AZKH_2677	COG1653	transport
AZKH_2678	COG0366	Alpha amylase catalytic
AZKH_2682	COG1737	Transcriptional regulator
AZKH_2682	COG0837	glucose binding
AZKH_2683	COG0673	inositol 2-dehydrogenase activity
AZKH_2684	COG3842	ATPase activity
AZKH_2685	COG0395	ABC-type sugar transport system, permease component
AZKH_2687	COG1653	transport
AZKH_2688	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AZKH_2689	COG0837	glucose binding
AZKH_2691	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AZKH_2696	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AZKH_2699	COG5001	Diguanylate cyclase
AZKH_2699	COG3300	MHYT domain
AZKH_2701	COG1902	pentaerythritol trinitrate reductase activity
AZKH_2702	COG0583	DNA-binding transcription factor activity
AZKH_2705	COG1172	Belongs to the binding-protein-dependent transport system permease family
AZKH_2706	COG1879	ABC-type sugar transport system periplasmic component
AZKH_2708	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AZKH_2712	COG0166	Belongs to the GPI family
AZKH_2713	COG1737	Transcriptional regulator
AZKH_2715	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AZKH_2717	COG0800	Aldolase
AZKH_2720	COG1012	belongs to the aldehyde dehydrogenase family
AZKH_2721	COG0148	phosphopyruvate hydratase activity
AZKH_2722	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AZKH_2724	COG0346	lactoylglutathione lyase activity
AZKH_2725	COG0598	Magnesium transport protein CorA
AZKH_2728	COG2202	Pas domain
AZKH_2728	COG2205	protein histidine kinase activity
AZKH_2730	COG0583	DNA-binding transcription factor activity
AZKH_2731	COG0477	Major facilitator Superfamily
AZKH_2732	COG1573	uracil-dna glycosylase
AZKH_2733	COG0456	acetyltransferase
AZKH_2734	COG1214	PFAM Peptidase M22, glycoprotease
AZKH_2736	COG0745	RESPONSE REGULATOR receiver
AZKH_2738	COG2917	probably involved in intracellular septation
AZKH_2739	COG2350	Protein conserved in bacteria
AZKH_2740	COG0271	Belongs to the BolA IbaG family
AZKH_2741	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AZKH_2742	COG1960	acyl-CoA dehydrogenase activity
AZKH_2745	COG1309	transcriptional regulator
AZKH_2746	COG0084	hydrolase, TatD family'
AZKH_2747	COG1024	Enoyl-CoA hydratase
AZKH_2750	COG1127	ABC transporter
AZKH_2751	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AZKH_2754	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AZKH_2761	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AZKH_2762	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AZKH_2764	COG1355	regulation of microtubule-based process
AZKH_2765	COG2078	PFAM AMMECR1 domain protein
AZKH_2768	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AZKH_2771	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AZKH_2772	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AZKH_2773	COG0450	alkyl hydroperoxide reductase
AZKH_2775	COG1704	LemA family
AZKH_2778	COG2259	Doxx family
AZKH_2782	COG4191	Histidine kinase
AZKH_2785	COG2151	metal-sulfur cluster biosynthetic enzyme
AZKH_2787	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AZKH_2788	COG0719	Fe-S assembly protein
AZKH_2789	COG0396	ATPase activity
AZKH_2790	COG0719	Fe-S assembly protein
AZKH_2792	COG1067	ATP-dependent peptidase activity
AZKH_2793	COG1335	isochorismatase
AZKH_2795	COG1881	PFAM PEBP family protein
AZKH_2800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AZKH_2802	COG1196	nuclear chromosome segregation
AZKH_2803	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AZKH_2804	COG2171	N-acyltransferase activity
AZKH_2806	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AZKH_2808	COG0784	Response regulator, receiver
AZKH_2810	COG0633	Ferredoxin
AZKH_2811	COG0443	Heat shock 70 kDa protein
AZKH_2812	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AZKH_2814	COG0822	iron-sulfur transferase activity
AZKH_2815	COG1104	cysteine desulfurase activity
AZKH_2816	COG1104	cysteine desulfurase activity
AZKH_2818	COG1045	serine acetyltransferase
AZKH_2821	COG0513	Belongs to the DEAD box helicase family
AZKH_2828	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AZKH_2829	COG0322	excinuclease ABC activity
AZKH_2830	COG1472	Belongs to the glycosyl hydrolase 3 family
AZKH_2831	COG0736	holo-[acyl-carrier-protein] synthase activity
AZKH_2832	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AZKH_2833	COG1381	Involved in DNA repair and RecF pathway recombination
AZKH_2834	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AZKH_2835	COG0571	ribonuclease III activity
AZKH_2837	COG0681	Belongs to the peptidase S26 family
AZKH_2838	COG0481	GTPase activity
AZKH_2840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZKH_2845	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AZKH_2848	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AZKH_2850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AZKH_2851	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AZKH_2852	COG0416	fatty acid biosynthetic process
AZKH_2853	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AZKH_2854	COG1399	metal-binding, possibly nucleic acid-binding protein
AZKH_2855	COG0424	maF-like protein
AZKH_2856	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AZKH_2858	COG0564	pseudouridine synthase activity
AZKH_2859	COG1530	ribonuclease E activity
AZKH_2860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AZKH_2861	COG0556	nucleotide-excision repair
AZKH_2866	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AZKH_2872	COG1067	ATP-dependent peptidase activity
AZKH_2874	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AZKH_2877	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AZKH_2878	COG1473	amidohydrolase
AZKH_2881	COG0084	hydrolase, TatD family'
AZKH_2885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AZKH_2886	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AZKH_2887	COG0354	folic acid binding
AZKH_2890	COG2153	protein acetylation
AZKH_2891	COG0590	tRNA wobble adenosine to inosine editing
AZKH_2893	COG0840	transmembrane signaling receptor activity
AZKH_2904	COG0243	molybdopterin cofactor binding
AZKH_2905	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AZKH_2906	COG3327	negative regulation of DNA-templated transcription, initiation
AZKH_2907	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AZKH_2908	COG1013	pyruvate-flavodoxin oxidoreductase activity
AZKH_2909	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AZKH_2909	COG0674	pyruvate-flavodoxin oxidoreductase activity
AZKH_2910	COG1846	Transcriptional regulator
AZKH_2911	COG4628	conserved protein (DUF2132)
AZKH_2916	COG1012	belongs to the aldehyde dehydrogenase family
AZKH_2921	COG1566	PFAM secretion protein HlyD family protein
AZKH_2924	COG2204	response regulator
AZKH_2930	COG4657	Part of a membrane complex involved in electron transport
AZKH_2933	COG4658	electron transport chain
AZKH_2934	COG4659	FMN binding
AZKH_2939	COG0776	regulation of translation
AZKH_2940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AZKH_2941	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AZKH_2942	COG0740	serine-type endopeptidase activity
AZKH_2943	COG0544	peptidyl-prolyl cis-trans isomerase activity
AZKH_2944	COG2766	serine protein kinase
AZKH_2945	COG2718	Belongs to the UPF0229 family
AZKH_2946	COG2719	SpoVR family
AZKH_2947	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AZKH_2947	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AZKH_2953	COG0697	spore germination
AZKH_2957	COG0436	Aminotransferase
AZKH_2959	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AZKH_2960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AZKH_2963	COG0791	NLP P60 protein
AZKH_2964	COG4191	Histidine kinase
AZKH_2965	COG0784	Response regulator, receiver
AZKH_2965	COG3437	response regulator, receiver
AZKH_2967	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AZKH_2976	COG3318	Belongs to the UPF0149 family
AZKH_2976	COG3012	SEC-C Motif Domain Protein
AZKH_2979	COG0254	rRNA binding
AZKH_2981	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AZKH_2982	COG0501	Belongs to the peptidase M48B family
AZKH_2983	COG1162	GTPase activity
AZKH_2984	COG0183	Belongs to the thiolase family
AZKH_2985	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
AZKH_2986	COG3384	dioxygenase
AZKH_2989	COG1490	D-aminoacyl-tRNA deacylase activity
AZKH_2995	COG1522	sequence-specific DNA binding
AZKH_2998	COG0071	Belongs to the small heat shock protein (HSP20) family
AZKH_3001	COG0501	Belongs to the peptidase M48B family
AZKH_3003	COG0579	oxidoreductase
AZKH_3004	COG1131	(ABC) transporter
AZKH_3006	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AZKH_3007	COG1451	nucleotide metabolic process
AZKH_3008	COG0513	Belongs to the DEAD box helicase family
AZKH_3012	COG1027	Aspartate ammonia-lyase
AZKH_3018	COG1404	Belongs to the peptidase S8 family
AZKH_3019	COG1132	(ABC) transporter
AZKH_3024	COG1012	belongs to the aldehyde dehydrogenase family
AZKH_3027	COG2409	Drug exporters of the RND superfamily
AZKH_3031	COG0840	transmembrane signaling receptor activity
AZKH_3040	COG3259	Nickel-dependent hydrogenase
AZKH_3041	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
AZKH_3042	COG3383	formate dehydrogenase (NAD+) activity
AZKH_3043	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AZKH_3044	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AZKH_3045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZKH_3047	COG0765	amino acid transport
AZKH_3048	COG0765	amino acid transport
AZKH_3049	COG1126	abc transporter atp-binding protein
AZKH_3053	COG1007	ATP synthesis coupled electron transport
AZKH_3056	COG0713	ATP synthesis coupled electron transport
AZKH_3058	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AZKH_3059	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AZKH_3060	COG1034	ATP synthesis coupled electron transport
AZKH_3063	COG0649	NAD binding
AZKH_3064	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AZKH_3066	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AZKH_3067	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AZKH_3070	COG0149	triose-phosphate isomerase activity
AZKH_3071	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AZKH_3072	COG0573	inorganic phosphate transmembrane transporter activity
AZKH_3073	COG0573	inorganic phosphate transmembrane transporter activity
AZKH_3074	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AZKH_3075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AZKH_3077	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AZKH_3078	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AZKH_3079	COG1534	Rna-binding protein
AZKH_3080	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AZKH_3081	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AZKH_3082	COG0505	Belongs to the CarA family
AZKH_3083	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AZKH_3085	COG0735	belongs to the Fur family
AZKH_3086	COG0497	DNA recombination
AZKH_3087	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AZKH_3088	COG1420	regulation of RNA biosynthetic process
AZKH_3089	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AZKH_3092	COG0515	serine threonine protein kinase
AZKH_3092	COG2815	serine threonine protein kinase
AZKH_3093	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AZKH_3094	COG0443	Heat shock 70 kDa protein
AZKH_3095	COG0484	heat shock protein binding
AZKH_3096	COG0215	cysteine-tRNA ligase activity
AZKH_3100	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AZKH_3101	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AZKH_3105	COG0285	dihydrofolate synthase activity
AZKH_3106	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AZKH_3107	COG0159	tryptophan synthase activity
AZKH_3108	COG0133	tryptophan synthase activity
AZKH_3109	COG0135	phosphoribosylanthranilate isomerase activity
AZKH_3110	COG0101	tRNA pseudouridine synthase activity
AZKH_3114	COG0473	3-isopropylmalate dehydrogenase activity
AZKH_3115	COG0066	3-isopropylmalate dehydratase activity
AZKH_3116	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AZKH_3117	COG4783	chaperone-mediated protein folding
AZKH_3118	COG2814	Major facilitator Superfamily
AZKH_3119	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AZKH_3120	COG0440	acetolactate synthase activity
AZKH_3121	COG0028	Belongs to the TPP enzyme family
AZKH_3122	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_3126	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AZKH_3127	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_3134	COG0277	FAD linked oxidase domain protein
AZKH_3135	COG1752	Esterase of the alpha-beta hydrolase superfamily
AZKH_3136	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AZKH_3137	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
AZKH_3139	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_3140	COG3243	poly(R)-hydroxyalkanoic acid synthase
AZKH_3143	COG0564	pseudouridine synthase activity
AZKH_3145	COG0662	Cupin 2, conserved barrel domain protein
AZKH_3145	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AZKH_3147	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AZKH_3148	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AZKH_3149	COG4521	taurine ABC transporter
AZKH_3152	COG2022	thiamine diphosphate biosynthetic process
AZKH_3154	COG2855	membrane
AZKH_3156	COG1113	amino acid transport
AZKH_3162	COG0523	cobalamin synthesis protein
AZKH_3166	COG0145	ligase activity
AZKH_3167	COG4647	ligase activity
AZKH_3168	COG0145	ligase activity
AZKH_3169	COG3284	Transcriptional regulator
AZKH_3172	COG2409	Drug exporters of the RND superfamily
AZKH_3172	COG1033	growth of symbiont in host cell
AZKH_3176	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AZKH_3177	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_3178	COG0405	Gamma-glutamyltransferase
AZKH_3180	COG1414	Transcriptional regulator
AZKH_3181	COG2951	lytic endotransglycosylase activity
AZKH_3183	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
AZKH_3187	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AZKH_3188	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AZKH_3190	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AZKH_3191	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AZKH_3192	COG1674	ftsk spoiiie
AZKH_3194	COG0492	ferredoxin-NADP+ reductase activity
AZKH_3195	COG2840	Smr protein MutS2
AZKH_3197	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AZKH_3197	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AZKH_3199	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AZKH_3202	COG2217	Heavy metal translocating P-type atpase
AZKH_3205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AZKH_3206	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AZKH_3207	COG3094	Invasion gene expression up-regulator, SirB
AZKH_3210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AZKH_3211	COG3243	poly(R)-hydroxyalkanoic acid synthase
AZKH_3216	COG2010	Cytochrome c
AZKH_3219	COG3278	Belongs to the heme-copper respiratory oxidase family
AZKH_3221	COG2217	Heavy metal translocating P-type atpase
AZKH_3223	COG0494	nUDIX hydrolase
AZKH_3232	COG1666	GTP binding
AZKH_3233	COG3123	guanosine phosphorylase activity
AZKH_3235	COG0137	argininosuccinate synthase activity
AZKH_3236	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AZKH_3237	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AZKH_3239	COG0268	Binds directly to 16S ribosomal RNA
AZKH_3240	COG0728	peptidoglycan biosynthetic process
AZKH_3243	COG0563	adenylate kinase activity
AZKH_3244	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AZKH_3245	COG2835	tetraacyldisaccharide 4'-kinase activity
AZKH_3246	COG1663	tetraacyldisaccharide 4'-kinase activity
AZKH_3247	COG0848	biopolymer transport protein
AZKH_3248	COG0811	peptide transport
AZKH_3249	COG1570	exodeoxyribonuclease VII activity
AZKH_3250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AZKH_3251	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AZKH_3257	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
AZKH_3258	COG4208	sulfate ABC transporter
AZKH_3259	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AZKH_3260	COG0583	DNA-binding transcription factor activity
AZKH_3261	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AZKH_3265	COG0643	Histidine kinase
AZKH_3265	COG2198	Histidine kinase
AZKH_3266	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AZKH_3267	COG0745	RESPONSE REGULATOR receiver
AZKH_3268	COG0835	chemotaxis
AZKH_3268	COG0784	Response regulator, receiver
AZKH_3269	COG0784	Response regulator, receiver
AZKH_3269	COG0835	chemotaxis
AZKH_3270	COG2201	protein-glutamate methylesterase activity
AZKH_3274	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AZKH_3277	COG0745	RESPONSE REGULATOR receiver
AZKH_3277	COG3706	GGDEF domain
AZKH_3279	COG0402	S-adenosylhomocysteine deaminase activity
AZKH_3280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AZKH_3282	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_3284	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AZKH_3285	COG1960	acyl-CoA dehydrogenase activity
AZKH_3289	COG0583	DNA-binding transcription factor activity
AZKH_3290	COG2423	ornithine cyclodeaminase activity
AZKH_3291	COG1522	sequence-specific DNA binding
AZKH_3292	COG1228	amidohydrolase
AZKH_3293	COG0010	Belongs to the arginase family
AZKH_3296	COG4191	Histidine kinase
AZKH_3299	COG2188	Transcriptional regulator
AZKH_3303	COG1073	alpha beta
AZKH_3307	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
AZKH_3308	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AZKH_3311	COG3657	addiction module killer protein
AZKH_3316	COG0784	Response regulator, receiver
AZKH_3316	COG2205	protein histidine kinase activity
AZKH_3316	COG5002	protein histidine kinase activity
AZKH_3318	COG4771	TonB-dependent receptor
AZKH_3321	COG4191	Histidine kinase
AZKH_3332	COG2059	Chromate
AZKH_3335	COG0251	oxidation-reduction process
AZKH_3336	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AZKH_3338	COG1953	Uracil, thiamine, allantoin
AZKH_3341	COG2186	Transcriptional regulator
AZKH_3342	COG1953	Uracil, thiamine, allantoin
AZKH_3343	COG4266	Belongs to the allantoicase family
AZKH_3344	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AZKH_3348	COG0765	amino acid transport
AZKH_3349	COG1126	abc transporter atp-binding protein
AZKH_3350	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AZKH_3352	COG1301	dicarboxylic acid transport
AZKH_3353	COG4266	Belongs to the allantoicase family
AZKH_3361	COG3409	Peptidoglycan-binding domain 1 protein
AZKH_3361	COG3267	Type II secretory pathway component ExeA
AZKH_3364	COG0583	DNA-binding transcription factor activity
AZKH_3367	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AZKH_3376	COG1278	Cold shock
AZKH_3386	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AZKH_3388	COG2197	response regulator
AZKH_3393	COG3960	tartronate-semialdehyde synthase activity
AZKH_3394	COG3622	Belongs to the hyi family
AZKH_3395	COG2084	Dehydrogenase
AZKH_3398	COG0469	pyruvate kinase activity
AZKH_3399	COG2259	Doxx family
AZKH_3401	COG0438	transferase activity, transferring glycosyl groups
AZKH_3401	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AZKH_3403	COG0697	spore germination
AZKH_3404	COG0004	ammonium transporteR
AZKH_3407	COG4876	unkown
AZKH_3408	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AZKH_3409	COG0210	DNA helicase
AZKH_3410	COG0784	Response regulator, receiver
AZKH_3410	COG3437	response regulator, receiver
AZKH_3412	COG0183	Belongs to the thiolase family
AZKH_3413	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_3414	COG1024	Enoyl-CoA hydratase
AZKH_3416	COG1960	acyl-CoA dehydrogenase activity
AZKH_3417	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AZKH_3419	COG1846	Transcriptional regulator
AZKH_3421	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_3422	COG1024	Enoyl-CoA hydratase
AZKH_3423	COG4191	Histidine kinase
AZKH_3425	COG4191	Histidine kinase
AZKH_3427	COG4191	Histidine kinase
AZKH_3428	COG1100	Small GTP-binding protein
AZKH_3429	COG2204	response regulator
AZKH_3432	COG3158	transport of potassium into the cell
AZKH_3433	COG2205	protein histidine kinase activity
AZKH_3434	COG0745	RESPONSE REGULATOR receiver
AZKH_3437	COG0745	RESPONSE REGULATOR receiver
AZKH_3439	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AZKH_3441	COG2363	Small membrane protein
AZKH_3443	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AZKH_3449	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AZKH_3451	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AZKH_3452	COG0628	permease
AZKH_3454	COG0560	Phosphoserine phosphatase
AZKH_3455	COG0617	tRNA 3'-terminal CCA addition
AZKH_3458	COG1428	Deoxynucleoside kinase
AZKH_3459	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AZKH_3460	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AZKH_3461	COG0517	IMP dehydrogenase activity
AZKH_3461	COG0516	GMP reductase activity
AZKH_3462	COG0308	aminopeptidase N
AZKH_3467	COG0028	Belongs to the TPP enzyme family
AZKH_3468	COG0440	acetolactate synthase activity
AZKH_3469	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AZKH_3470	COG0688	phosphatidylethanolamine metabolic process
AZKH_3471	COG1183	phosphatidylcholine synthase activity
AZKH_3472	COG2205	protein histidine kinase activity
AZKH_3473	COG0745	RESPONSE REGULATOR receiver
AZKH_3478	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AZKH_3481	COG1295	ribonuclease BN
AZKH_3483	COG0228	four-way junction DNA binding
AZKH_3484	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AZKH_3485	COG0336	Belongs to the RNA methyltransferase TrmD family
AZKH_3486	COG0335	large ribosomal subunit rRNA binding
AZKH_3488	COG0527	aspartate kinase activity
AZKH_3491	COG0720	synthase
AZKH_3492	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
AZKH_3492	COG3264	Mechanosensitive ion channel
AZKH_3494	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AZKH_3494	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AZKH_3496	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AZKH_3497	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AZKH_3498	COG0187	DNA topoisomerase II activity
AZKH_3500	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AZKH_3501	COG1984	allophanate hydrolase subunit 2
AZKH_3502	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AZKH_3504	COG4336	lyase activity
AZKH_3505	COG0583	DNA-binding transcription factor activity
AZKH_3507	COG1360	Flagellar Motor Protein
AZKH_3508	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AZKH_3509	COG1191	sigma factor activity
AZKH_3512	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AZKH_3513	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AZKH_3517	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AZKH_3519	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AZKH_3520	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AZKH_3521	COG0123	including yeast histone deacetylase and acetoin utilization protein
AZKH_3522	COG0714	Associated with various cellular activities
AZKH_3525	COG2951	lytic endotransglycosylase activity
AZKH_3528	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AZKH_3529	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AZKH_3532	COG0776	regulation of translation
AZKH_3533	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AZKH_3533	COG0072	phenylalanine-tRNA ligase activity
AZKH_3534	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AZKH_3535	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AZKH_3536	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AZKH_3537	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AZKH_3538	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AZKH_3541	COG0535	radical SAM domain protein
AZKH_3545	COG3391	amine dehydrogenase activity
AZKH_3547	COG1648	precorrin-2 dehydrogenase activity
AZKH_3547	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AZKH_3552	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
AZKH_3554	COG0776	regulation of translation
AZKH_3556	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AZKH_3557	COG0287	Prephenate dehydrogenase
AZKH_3559	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AZKH_3561	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AZKH_3561	COG2885	chlorophyll binding
AZKH_3562	COG0402	S-adenosylhomocysteine deaminase activity
AZKH_3564	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AZKH_3565	COG0346	lactoylglutathione lyase activity
AZKH_3567	COG1058	Belongs to the CinA family
AZKH_3567	COG1546	Belongs to the CinA family
AZKH_3569	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AZKH_3574	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AZKH_3577	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AZKH_3578	COG2204	response regulator
AZKH_3581	COG0494	nUDIX hydrolase
AZKH_3582	COG0071	Belongs to the small heat shock protein (HSP20) family
AZKH_3583	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AZKH_3585	COG0175	sulfate reduction
AZKH_3586	COG1218	3'(2'),5'-bisphosphate nucleotidase
AZKH_3587	COG3273	potassium ion transport
AZKH_3587	COG0471	metal ion transport
AZKH_3588	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AZKH_3589	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_3594	COG0726	polysaccharide deacetylase
AZKH_3595	COG1215	transferase activity, transferring glycosyl groups
AZKH_3598	COG1216	Glycosyl transferase, family 2
AZKH_3601	COG1696	Membrane protein involved in D-alanine export
AZKH_3606	COG0438	transferase activity, transferring glycosyl groups
AZKH_3610	COG0367	asparagine synthase
AZKH_3614	COG0438	transferase activity, transferring glycosyl groups
AZKH_3616	COG0438	transferase activity, transferring glycosyl groups
AZKH_3617	COG0367	asparagine synthase
AZKH_3618	COG0438	transferase activity, transferring glycosyl groups
AZKH_3622	COG3267	Type II secretory pathway component ExeA
AZKH_3622	COG3409	Peptidoglycan-binding domain 1 protein
AZKH_3624	COG0489	protein tyrosine kinase activity
AZKH_3626	COG1596	polysaccharide export
AZKH_3629	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AZKH_3631	COG0109	protoheme IX farnesyltransferase activity
AZKH_3632	COG1612	heme a metabolic process
AZKH_3637	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AZKH_3638	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AZKH_3640	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AZKH_3641	COG3852	Histidine kinase
AZKH_3643	COG4251	negative regulation of phosphorylation
AZKH_3643	COG2203	Gaf domain
AZKH_3643	COG3706	GGDEF domain
AZKH_3643	COG5001	Diguanylate cyclase
AZKH_3645	COG0514	ATP-dependent DNA helicase (RecQ)
AZKH_3647	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AZKH_3653	COG1132	(ABC) transporter
AZKH_3655	COG0840	transmembrane signaling receptor activity
AZKH_3659	COG0745	RESPONSE REGULATOR receiver
AZKH_3660	COG0642	Histidine kinase
AZKH_3664	COG0411	ABC transporter
AZKH_3666	COG1522	sequence-specific DNA binding
AZKH_3668	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AZKH_3670	COG0134	indole-3-glycerol-phosphate synthase activity
AZKH_3671	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AZKH_3672	COG0512	Glutamine amidotransferase of anthranilate synthase
AZKH_3674	COG0546	phosphoglycolate phosphatase activity
AZKH_3675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AZKH_3676	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AZKH_3677	COG1234	tRNA 3'-trailer cleavage
AZKH_3678	COG1716	ATPase activity
AZKH_3685	COG4566	intracellular signal transduction
AZKH_3686	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AZKH_3687	COG0037	tRNA processing
AZKH_3688	COG0825	malonyl-CoA metabolic process
AZKH_3689	COG1253	flavin adenine dinucleotide binding
AZKH_3690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AZKH_3691	COG0670	Belongs to the BI1 family
AZKH_3694	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AZKH_3695	COG0343	queuine tRNA-ribosyltransferase activity
AZKH_3696	COG1862	Preprotein translocase
AZKH_3698	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AZKH_3699	COG2095	MarC family integral membrane protein
AZKH_3702	COG2967	ApaG domain
AZKH_3703	COG4191	Histidine kinase
AZKH_3703	COG0784	Response regulator, receiver
AZKH_3704	COG4566	intracellular signal transduction
AZKH_3707	COG1366	Belongs to the anti-sigma-factor antagonist family
AZKH_3708	COG2198	Histidine kinase
AZKH_3708	COG0643	Histidine kinase
AZKH_3709	COG0840	transmembrane signaling receptor activity
AZKH_3710	COG0835	chemotaxis
AZKH_3711	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AZKH_3715	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AZKH_3717	COG0653	protein targeting
AZKH_3720	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AZKH_3721	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AZKH_3723	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AZKH_3724	COG1181	Belongs to the D-alanine--D-alanine ligase family
AZKH_3725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AZKH_3726	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AZKH_3727	COG0772	Belongs to the SEDS family
AZKH_3728	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AZKH_3729	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AZKH_3730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AZKH_3731	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AZKH_3734	COG0275	rRNA processing
AZKH_3735	COG2001	Belongs to the MraZ family
AZKH_3737	COG0418	dihydroorotase activity
AZKH_3739	COG0792	nuclease activity
AZKH_3740	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AZKH_3741	COG2823	Periplasmic or secreted lipoprotein
AZKH_3742	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AZKH_3744	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AZKH_3745	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AZKH_3746	COG0511	ligase activity, forming carbon-carbon bonds
AZKH_3747	COG0439	Biotin carboxylase
AZKH_3748	COG2264	protein methyltransferase activity
AZKH_3755	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AZKH_3757	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AZKH_3771	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AZKH_3774	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AZKH_3778	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AZKH_3779	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AZKH_3783	COG0840	transmembrane signaling receptor activity
AZKH_3784	COG4191	Histidine kinase
AZKH_3786	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AZKH_3787	COG2204	response regulator
AZKH_3788	COG1024	Enoyl-CoA hydratase
AZKH_3788	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AZKH_3789	COG0309	Hydrogenase expression formation protein (HypE)
AZKH_3791	COG0409	Hydrogenase expression formation protein
AZKH_3792	COG0298	carbon dioxide binding
AZKH_3793	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AZKH_3795	COG0375	protein maturation
AZKH_3799	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AZKH_3800	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AZKH_3801	COG5557	Pfam Polysulphide reductase, NrfD
AZKH_3802	COG0437	4 iron, 4 sulfur cluster binding
AZKH_3803	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AZKH_3804	COG3338	carbonate dehydratase activity
AZKH_3805	COG2119	membrane
AZKH_3806	COG0351	phosphomethylpyrimidine kinase
AZKH_3807	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AZKH_3808	COG0622	Phosphoesterase
AZKH_3809	COG3258	Cytochrome c
AZKH_3810	COG2022	thiamine diphosphate biosynthetic process
AZKH_3812	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AZKH_3814	COG0022	dehydrogenase e1 component
AZKH_3815	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AZKH_3816	COG3284	Transcriptional regulator
AZKH_3822	COG1968	undecaprenyl-diphosphatase activity
AZKH_3823	COG3150	esterase
AZKH_3824	COG2226	methyltransferase
AZKH_3825	COG2962	Rard protein
AZKH_3826	COG0557	exoribonuclease II activity
AZKH_3828	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AZKH_3829	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AZKH_3830	COG2239	Acts as a magnesium transporter
AZKH_3831	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AZKH_3832	COG0352	thiamine-phosphate diphosphorylase activity
AZKH_3833	COG0351	phosphomethylpyrimidine kinase
AZKH_3837	COG0840	transmembrane signaling receptor activity
AZKH_3838	COG0643	Histidine kinase
AZKH_3838	COG2198	Histidine kinase
AZKH_3839	COG0415	Belongs to the DNA photolyase family
AZKH_3840	COG1678	Uncharacterized ACR, COG1678
AZKH_3841	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AZKH_3842	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AZKH_3843	COG0540	Belongs to the ATCase OTCase family
AZKH_3845	COG1872	DUF167
AZKH_3846	COG0762	integral membrane protein
AZKH_3853	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AZKH_3855	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AZKH_3856	COG4654	Cytochrome c, class I
AZKH_3857	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AZKH_3857	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AZKH_3860	COG2200	EAL domain
AZKH_3864	COG2197	response regulator
AZKH_3865	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AZKH_3870	COG1121	(ABC) transporter
AZKH_3872	COG0803	Belongs to the bacterial solute-binding protein 9 family
AZKH_3873	COG1280	lysine exporter protein (LysE YggA)
AZKH_3874	COG0730	response to heat
AZKH_3875	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AZKH_3877	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AZKH_3878	COG0129	dihydroxy-acid dehydratase activity
AZKH_3879	COG3132	Protein of unknown function, DUF480
AZKH_3880	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AZKH_3892	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AZKH_3893	COG1136	(ABC) transporter
AZKH_3893	COG0577	efflux transmembrane transporter activity
AZKH_3894	COG1538	Outer membrane efflux protein
AZKH_3903	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AZKH_3903	COG3608	succinylglutamate desuccinylase aspartoacylase
AZKH_3908	COG3781	membrane
AZKH_3911	COG2010	Cytochrome c
AZKH_3914	COG0642	Histidine kinase
AZKH_3919	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AZKH_3928	COG0436	Aminotransferase
AZKH_3929	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AZKH_3930	COG0235	Class ii aldolase
AZKH_3931	COG2084	Dehydrogenase
AZKH_3932	COG2084	Dehydrogenase
AZKH_3933	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AZKH_3935	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AZKH_3936	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AZKH_3942	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AZKH_3945	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AZKH_3947	COG0745	RESPONSE REGULATOR receiver
AZKH_3947	COG3706	GGDEF domain
AZKH_3954	COG3437	response regulator, receiver
AZKH_3956	COG0745	RESPONSE REGULATOR receiver
AZKH_3958	COG0784	Response regulator, receiver
AZKH_3958	COG2198	Histidine kinase
AZKH_3958	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZKH_3958	COG2205	protein histidine kinase activity
AZKH_3959	COG0784	Response regulator, receiver
AZKH_3959	COG4191	Histidine kinase
AZKH_3961	COG2201	protein-glutamate methylesterase activity
AZKH_3962	COG0840	transmembrane signaling receptor activity
AZKH_3963	COG0835	chemotaxis
AZKH_3964	COG0840	transmembrane signaling receptor activity
AZKH_3965	COG2198	Histidine kinase
AZKH_3965	COG0643	Histidine kinase
AZKH_3967	COG0629	single-stranded DNA binding
AZKH_3968	COG2814	Major facilitator Superfamily
AZKH_3971	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AZKH_3972	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AZKH_3973	COG0203	ribosomal protein L17
AZKH_3974	COG0202	RNA polymerase activity
AZKH_3975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AZKH_3976	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AZKH_3977	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AZKH_3978	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AZKH_3979	COG0201	protein transport
AZKH_3980	COG0200	Binds to the 23S rRNA
AZKH_3981	COG1841	ribosomal large subunit assembly
AZKH_3982	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AZKH_3983	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AZKH_3984	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AZKH_3985	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AZKH_3986	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AZKH_3987	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AZKH_3988	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AZKH_3989	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AZKH_3990	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AZKH_3991	COG0255	Belongs to the universal ribosomal protein uL29 family
AZKH_3992	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AZKH_3993	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AZKH_3994	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AZKH_3995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AZKH_3996	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AZKH_3997	COG0089	rRNA binding
AZKH_3998	COG0088	Forms part of the polypeptide exit tunnel
AZKH_3999	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AZKH_4000	COG0051	transcription antitermination factor activity, RNA binding
AZKH_4001	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AZKH_4002	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AZKH_4003	COG0049	tRNA binding
AZKH_4004	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AZKH_4005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AZKH_4006	COG0085	RNA polymerase activity
AZKH_4007	COG0222	ribosome binding
AZKH_4008	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AZKH_4009	COG0081	regulation of translation
AZKH_4010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AZKH_4012	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AZKH_4014	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AZKH_4018	COG0277	FAD linked oxidase domain protein
AZKH_4024	COG2198	Histidine kinase
AZKH_4024	COG2205	protein histidine kinase activity
AZKH_4024	COG0784	Response regulator, receiver
AZKH_4027	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AZKH_4032	COG0559	Belongs to the binding-protein-dependent transport system permease family
AZKH_4034	COG1022	Amp-dependent synthetase and ligase
AZKH_4041	COG0586	Pfam SNARE associated Golgi protein
AZKH_4043	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AZKH_4043	COG1703	isobutyryl-CoA mutase activity
AZKH_4043	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AZKH_4049	COG3746	phosphate-selective porin O and P
AZKH_4053	COG2321	neutral zinc metallopeptidase
AZKH_4054	COG3706	GGDEF domain
AZKH_4054	COG2203	Gaf domain
AZKH_4054	COG5001	Diguanylate cyclase
AZKH_4054	COG4251	negative regulation of phosphorylation
AZKH_4055	COG4191	Histidine kinase
AZKH_4056	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AZKH_4057	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AZKH_4061	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AZKH_4064	COG5554	nitrogen fixation
AZKH_4068	COG5554	nitrogen fixation
AZKH_4070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AZKH_4072	COG0740	serine-type endopeptidase activity
AZKH_4073	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AZKH_4075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AZKH_4078	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
AZKH_4080	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AZKH_4081	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AZKH_4082	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AZKH_4085	COG5420	small protein containing a coiled-coil domain
AZKH_4086	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
AZKH_4090	COG1620	l-lactate permease
AZKH_4093	COG1584	GPR1 FUN34 yaaH family protein
AZKH_4095	COG2116	formate transmembrane transporter activity
AZKH_4096	COG0515	serine threonine protein kinase
AZKH_4108	COG0443	Heat shock 70 kDa protein
AZKH_4110	COG0316	Belongs to the HesB IscA family
AZKH_4111	COG0822	iron-sulfur transferase activity
AZKH_4112	COG1104	cysteine desulfurase activity
AZKH_4113	COG0439	Biotin carboxylase
AZKH_4114	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AZKH_4115	COG1703	isobutyryl-CoA mutase activity
AZKH_4116	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AZKH_4116	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AZKH_4117	COG1802	Transcriptional regulator
AZKH_4118	COG0114	fumarate hydratase activity
AZKH_4119	COG4585	Histidine kinase
AZKH_4124	COG2197	response regulator
AZKH_4135	COG4964	Belongs to the GSP D family
AZKH_4145	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AZKH_4146	COG3162	membrane
AZKH_4147	COG1024	Enoyl-CoA hydratase
AZKH_4148	COG1492	cobalamin metabolic process
AZKH_4150	COG1242	4 iron, 4 sulfur cluster binding
AZKH_4151	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AZKH_4153	COG0513	Belongs to the DEAD box helicase family
AZKH_4158	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AZKH_4167	COG0427	acetyl-CoA hydrolase
AZKH_4169	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AZKH_4173	COG0583	DNA-binding transcription factor activity
AZKH_4175	COG0393	Putative heavy-metal-binding
AZKH_4176	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AZKH_4180	COG0686	Belongs to the AlaDH PNT family
AZKH_4181	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AZKH_4186	COG3706	GGDEF domain
AZKH_4186	COG0745	RESPONSE REGULATOR receiver
AZKH_4187	COG2197	response regulator
AZKH_4189	COG1858	cytochrome C peroxidase
AZKH_4190	COG4191	Histidine kinase
AZKH_4192	COG2204	response regulator
AZKH_4194	COG0745	RESPONSE REGULATOR receiver
AZKH_4196	COG2198	Histidine kinase
AZKH_4196	COG0643	Histidine kinase
AZKH_4198	COG0840	transmembrane signaling receptor activity
AZKH_4199	COG0835	chemotaxis
AZKH_4201	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
AZKH_4202	COG2201	protein-glutamate methylesterase activity
AZKH_4205	COG0537	adenosine 5'-monophosphoramidase activity
AZKH_4206	COG0557	exoribonuclease II activity
AZKH_4207	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AZKH_4208	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AZKH_4209	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AZKH_4211	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AZKH_4213	COG0069	glutamate synthase activity
AZKH_4213	COG0067	glutamate synthase
AZKH_4213	COG0070	glutamate synthase
AZKH_4214	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AZKH_4215	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AZKH_4216	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AZKH_4220	COG3166	PFAM Fimbrial assembly family protein
AZKH_4223	COG1965	Belongs to the frataxin family
AZKH_4233	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AZKH_4234	COG0284	orotidine-5'-phosphate decarboxylase activity
AZKH_4236	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AZKH_4237	COG3161	chorismate lyase activity
AZKH_4240	COG2204	response regulator
AZKH_4244	COG0517	IMP dehydrogenase activity
AZKH_4246	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AZKH_4248	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AZKH_4256	COG1858	cytochrome C peroxidase
AZKH_4258	COG1741	Belongs to the pirin family
AZKH_4259	COG1024	Enoyl-CoA hydratase
AZKH_4262	COG0183	Belongs to the thiolase family
AZKH_4263	COG1024	Enoyl-CoA hydratase
AZKH_4263	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_4264	COG2067	long-chain fatty acid transport protein
AZKH_4265	COG1607	acyl-coa hydrolase
AZKH_4266	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_4266	COG1024	Enoyl-CoA hydratase
AZKH_4268	COG1960	acyl-CoA dehydrogenase activity
AZKH_4273	COG4178	(ABC) transporter
AZKH_4275	COG0366	Alpha amylase catalytic
AZKH_4276	COG1322	Protein conserved in bacteria
AZKH_4277	COG5265	(ABC) transporter
AZKH_4279	COG0252	asparaginase activity
AZKH_4280	COG0583	DNA-binding transcription factor activity
AZKH_4281	COG0730	response to heat
AZKH_4284	COG0175	sulfate reduction
AZKH_4285	COG0175	sulfate reduction
AZKH_4286	COG2895	sulfate adenylyltransferase (ATP) activity
AZKH_4289	COG0330	HflC and HflK could
AZKH_4292	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AZKH_4293	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AZKH_4295	COG0824	Thioesterase
AZKH_4299	COG0823	Involved in the tonB-independent uptake of proteins
AZKH_4301	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AZKH_4302	COG0602	queuosine metabolic process
AZKH_4303	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AZKH_4305	COG2204	response regulator
AZKH_4308	COG1671	Belongs to the UPF0178 family
AZKH_4309	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AZKH_4312	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_4320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AZKH_4321	COG1546	Belongs to the CinA family
AZKH_4322	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AZKH_4323	COG2137	regulation of response to DNA damage stimulus
AZKH_4324	COG1137	ATPase activity
AZKH_4325	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AZKH_4326	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AZKH_4328	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AZKH_4329	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AZKH_4331	COG0741	lytic transglycosylase activity
AZKH_4334	COG0617	tRNA 3'-terminal CCA addition
AZKH_4336	COG2267	carboxylic ester hydrolase activity
AZKH_4340	COG0037	tRNA processing
AZKH_4343	COG1238	metal cluster binding
AZKH_4344	COG0251	oxidation-reduction process
AZKH_4347	COG0243	molybdopterin cofactor binding
AZKH_4349	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AZKH_4350	COG0708	Exodeoxyribonuclease III
AZKH_4351	COG2169	Transcriptional regulator
AZKH_4351	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AZKH_4354	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
AZKH_4358	COG2814	Major facilitator Superfamily
AZKH_4367	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AZKH_4376	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AZKH_4378	COG0861	Integral membrane protein TerC family
AZKH_4379	COG4772	TonB-dependent receptor
AZKH_4381	COG3876	Protein conserved in bacteria
AZKH_4382	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AZKH_4386	COG0730	response to heat
AZKH_4391	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AZKH_4393	COG2267	carboxylic ester hydrolase activity
AZKH_4401	COG0411	ABC transporter
AZKH_4405	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_4406	COG0574	Belongs to the PEP-utilizing enzyme family
AZKH_4406	COG3848	Pyruvate phosphate dikinase
AZKH_4412	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AZKH_4413	COG2814	Major facilitator Superfamily
AZKH_4415	COG3706	GGDEF domain
AZKH_4415	COG0745	RESPONSE REGULATOR receiver
AZKH_4418	COG1801	Protein of unknown function DUF72
AZKH_4419	COG0606	chelatase, subunit chli
AZKH_4422	COG0347	Belongs to the P(II) protein family
AZKH_4423	COG0004	ammonium transporteR
AZKH_4426	COG0788	formyltetrahydrofolate deformylase activity
AZKH_4428	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AZKH_4430	COG0488	(ABC) transporter
AZKH_4434	COG0583	DNA-binding transcription factor activity
AZKH_4436	COG0189	ligase activity
AZKH_4443	COG2329	Antibiotic biosynthesis monooxygenase
AZKH_4446	COG1561	YicC-like family, N-terminal region
AZKH_4447	COG0515	serine threonine protein kinase
AZKH_4447	COG2815	serine threonine protein kinase
AZKH_4448	COG0631	protein serine/threonine phosphatase activity
AZKH_4449	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AZKH_4450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AZKH_4451	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AZKH_4452	COG0616	signal peptide processing
AZKH_4453	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AZKH_4454	COG2022	thiamine diphosphate biosynthetic process
AZKH_4460	COG2032	superoxide dismutase activity
AZKH_4462	COG0022	dehydrogenase e1 component
AZKH_4463	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AZKH_4464	COG1956	GAF domain-containing protein
AZKH_4466	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AZKH_4467	COG1194	a g-specific adenine glycosylase
AZKH_4472	COG0559	Belongs to the binding-protein-dependent transport system permease family
AZKH_4473	COG2860	membrane
AZKH_4479	COG1970	mechanosensitive ion channel activity
AZKH_4480	COG0745	RESPONSE REGULATOR receiver
AZKH_4481	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AZKH_4482	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AZKH_4487	COG0840	transmembrane signaling receptor activity
AZKH_4488	COG4633	Protein conserved in bacteria
AZKH_4498	COG3383	formate dehydrogenase (NAD+) activity
AZKH_4504	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_4510	COG0411	ABC transporter
AZKH_4524	COG2273	Hydrolase Family 16
AZKH_4524	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AZKH_4531	COG0488	(ABC) transporter
AZKH_4534	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
AZKH_4535	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AZKH_4536	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AZKH_4540	COG0745	RESPONSE REGULATOR receiver
AZKH_4540	COG3706	GGDEF domain
AZKH_4541	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AZKH_4542	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AZKH_4542	COG2813	Specifically methylates the guanine in position
AZKH_4545	COG2814	Major facilitator Superfamily
AZKH_4572	COG3245	cytochrome
AZKH_4575	COG3033	Beta-eliminating lyase
AZKH_4577	COG1940	carbohydrate kinase activity
AZKH_4578	COG2258	MOSC domain
AZKH_4579	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AZKH_4580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AZKH_4582	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AZKH_4583	COG0830	nickel cation binding
AZKH_4584	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AZKH_4585	COG0804	urea catabolic process
AZKH_4586	COG0832	Belongs to the urease beta subunit family
AZKH_4587	COG0831	urea catabolic process
AZKH_4588	COG0829	nickel cation binding
AZKH_4590	COG3706	GGDEF domain
AZKH_4594	COG1295	ribonuclease BN
AZKH_4598	COG0559	Belongs to the binding-protein-dependent transport system permease family
AZKH_4600	COG2204	response regulator
AZKH_4601	COG5000	phosphorelay sensor kinase activity
AZKH_4604	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AZKH_4607	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AZKH_4608	COG0706	membrane insertase activity
AZKH_4609	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AZKH_4610	COG0594	ribonuclease P activity
AZKH_p0001	COG0583	DNA-binding transcription factor activity
AZKH_p0003	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AZKH_p0004	COG1113	amino acid transport
AZKH_p0005	COG0251	oxidation-reduction process
AZKH_p0006	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AZKH_p0012	COG0583	DNA-binding transcription factor activity
AZKH_p0013	COG1473	amidohydrolase
AZKH_p0016	COG0154	amidase activity
AZKH_p0020	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AZKH_p0021	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AZKH_p0022	COG1012	belongs to the aldehyde dehydrogenase family
AZKH_p0023	COG0583	DNA-binding transcription factor activity
AZKH_p0024	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AZKH_p0026	COG0583	DNA-binding transcription factor activity
AZKH_p0028	COG1953	Uracil, thiamine, allantoin
AZKH_p0031	COG0477	Major facilitator Superfamily
AZKH_p0032	COG3842	ATPase activity
AZKH_p0034	COG1176	ABC-type spermidine putrescine transport system, permease component I
AZKH_p0041	COG2226	methyltransferase
AZKH_p0043	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AZKH_p0046	COG0798	PFAM Bile acid sodium symporter
AZKH_p0048	COG2204	response regulator
AZKH_p0049	COG3852	Histidine kinase
AZKH_p0053	COG0243	molybdopterin cofactor binding
AZKH_p0056	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AZKH_p0062	COG0583	DNA-binding transcription factor activity
AZKH_p0064	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
AZKH_p0065	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
AZKH_p0067	COG1960	acyl-CoA dehydrogenase activity
AZKH_p0068	COG0183	Belongs to the thiolase family
AZKH_p0069	COG1024	Enoyl-CoA hydratase
AZKH_p0069	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_p0074	COG2186	Transcriptional regulator
AZKH_p0075	COG2271	Major facilitator Superfamily
AZKH_p0076	COG2084	Dehydrogenase
AZKH_p0077	COG3395	kinase activity
AZKH_p0078	COG0235	Class ii aldolase
AZKH_p0079	COG3622	Belongs to the hyi family
AZKH_p0080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AZKH_p0081	COG2084	Dehydrogenase
AZKH_p0083	COG1116	anion transmembrane transporter activity
AZKH_p0087	COG1360	Flagellar Motor Protein
AZKH_p0089	COG0625	glutathione transferase activity
AZKH_p0092	COG1272	protein, Hemolysin III
AZKH_p0093	COG1408	metallophosphoesterase
AZKH_p0097	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AZKH_p0098	COG2009	succinate dehydrogenase
AZKH_p0099	COG0583	DNA-binding transcription factor activity
AZKH_p0103	COG0024	Methionine aminopeptidase
AZKH_p0107	COG3851	Histidine kinase
AZKH_p0109	COG2176	DNA-directed DNA polymerase activity
AZKH_p0112	COG1011	Hydrolase
AZKH_p0122	COG1280	lysine exporter protein (LysE YggA)
AZKH_p0123	COG2828	Protein conserved in bacteria
AZKH_p0129	COG0574	Belongs to the PEP-utilizing enzyme family
AZKH_p0129	COG3848	Pyruvate phosphate dikinase
AZKH_p0130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AZKH_p0130	COG0574	Belongs to the PEP-utilizing enzyme family
AZKH_p0131	COG0517	IMP dehydrogenase activity
AZKH_p0133	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AZKH_p0136	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AZKH_p0140	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AZKH_p0143	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AZKH_p0146	COG2076	Multidrug Resistance protein
AZKH_p0149	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AZKH_p0150	COG1012	belongs to the aldehyde dehydrogenase family
AZKH_p0153	COG0730	response to heat
AZKH_p0154	COG0583	DNA-binding transcription factor activity
AZKH_p0157	COG2267	carboxylic ester hydrolase activity
AZKH_p0158	COG0604	alcohol dehydrogenase
AZKH_p0160	COG1902	pentaerythritol trinitrate reductase activity
AZKH_p0169	COG5012	cobalamin binding
AZKH_p0178	COG0285	dihydrofolate synthase activity
AZKH_p0179	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AZKH_p0182	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AZKH_p0182	COG0446	pyridine nucleotide-disulphide oxidoreductase
AZKH_p0185	COG1760	l-serine dehydratase
AZKH_p0186	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AZKH_p0187	COG0840	transmembrane signaling receptor activity
AZKH_p0193	COG0750	zinc metalloprotease
AZKH_p0203	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AZKH_p0209	COG2197	response regulator
AZKH_p0210	COG3850	Histidine kinase
AZKH_p0216	COG0247	lactate metabolic process
AZKH_p0216	COG2181	nitrate reductase activity
AZKH_p0218	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AZKH_p0219	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AZKH_p0222	COG3344	reverse transcriptase
AZKH_p0223	COG0191	fructose-bisphosphate aldolase activity
AZKH_p0224	COG0126	phosphoglycerate kinase activity
AZKH_p0225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AZKH_p0226	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AZKH_p0227	COG3954	Phosphoribulokinase
AZKH_p0230	COG4451	ribulose bisphosphate carboxylase, small
AZKH_p0234	COG0302	gtp cyclohydrolase
AZKH_p0240	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
AZKH_p0241	COG1229	Formylmethanofuran dehydrogenase subunit A
AZKH_p0245	COG3437	response regulator, receiver
AZKH_p0249	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZKH_p0249	COG4191	Histidine kinase
AZKH_p0250	COG0784	Response regulator, receiver
AZKH_p0250	COG3437	response regulator, receiver
AZKH_p0258	COG2010	Cytochrome c
AZKH_p0268	COG3284	Transcriptional regulator
AZKH_p0270	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
AZKH_p0272	COG0189	ligase activity
AZKH_p0273	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
AZKH_p0274	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AZKH_p0275	COG0702	epimerase
AZKH_p0279	COG3383	formate dehydrogenase (NAD+) activity
AZKH_p0280	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AZKH_p0283	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_p0286	COG1012	belongs to the aldehyde dehydrogenase family
AZKH_p0287	COG2010	Cytochrome c
AZKH_p0287	COG4993	Dehydrogenase
AZKH_p0289	COG0679	Auxin Efflux Carrier
AZKH_p0291	COG0028	Belongs to the TPP enzyme family
AZKH_p0296	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_p0298	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AZKH_p0299	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AZKH_p0300	COG3550	peptidyl-serine autophosphorylation
AZKH_p0302	COG1280	lysine exporter protein (LysE YggA)
AZKH_p0304	COG1131	(ABC) transporter
AZKH_p0305	COG0842	Transport permease protein
AZKH_p0306	COG0842	Transport permease protein
AZKH_p0310	COG1609	Transcriptional regulator
AZKH_p0317	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AZKH_p0319	COG0745	RESPONSE REGULATOR receiver
AZKH_p0320	COG5002	protein histidine kinase activity
AZKH_p0328	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AZKH_p0332	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_p0333	COG1960	acyl-CoA dehydrogenase activity
AZKH_p0339	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_p0342	COG0427	acetyl-CoA hydrolase
AZKH_p0343	COG0183	Belongs to the thiolase family
AZKH_p0346	COG2365	Tyrosine phosphatase family
AZKH_p0347	COG0183	Belongs to the thiolase family
AZKH_p0350	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_p0352	COG2030	dehydratase
AZKH_p0353	COG1024	Enoyl-CoA hydratase
AZKH_p0353	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_p0354	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AZKH_p0355	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_p0356	COG1960	acyl-CoA dehydrogenase activity
AZKH_p0357	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AZKH_p0363	COG2814	Major facilitator Superfamily
AZKH_p0367	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AZKH_p0368	COG1127	ABC transporter
AZKH_p0373	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AZKH_p0374	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AZKH_p0376	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AZKH_p0380	COG2010	Cytochrome c
AZKH_p0385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AZKH_p0387	COG2203	Gaf domain
AZKH_p0387	COG3706	GGDEF domain
AZKH_p0387	COG4251	negative regulation of phosphorylation
AZKH_p0387	COG5001	Diguanylate cyclase
AZKH_p0388	COG2201	protein-glutamate methylesterase activity
AZKH_p0393	COG0840	transmembrane signaling receptor activity
AZKH_p0394	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AZKH_p0396	COG4269	membrane
AZKH_p0397	COG0501	Belongs to the peptidase M48B family
AZKH_p0398	COG5002	protein histidine kinase activity
AZKH_p0398	COG5001	Diguanylate cyclase
AZKH_p0398	COG3447	MASE1 domain protein
AZKH_p0399	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AZKH_p0399	COG0316	Belongs to the HesB IscA family
AZKH_p0411	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AZKH_p0414	COG0435	Glutathione S-transferase
AZKH_p0417	COG1446	asparaginase
AZKH_p0419	COG0545	Peptidyl-prolyl cis-trans isomerase
AZKH_p0427	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AZKH_p0429	COG1192	Involved in chromosome partitioning
AZKH_p0445	COG1335	isochorismatase
AZKH_p0446	COG3135	benzoate transporter
AZKH_p0447	COG1396	sequence-specific DNA binding
AZKH_p0465	COG2425	protein containing a von Willebrand factor type A (vWA) domain
AZKH_p0466	COG0714	Associated with various cellular activities
AZKH_p0467	COG0508	dehydrogenase complex catalyzes the overall conversion of
AZKH_p0468	COG0567	Dehydrogenase, E1 component
AZKH_p0469	COG1012	belongs to the aldehyde dehydrogenase family
AZKH_p0471	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AZKH_p0472	COG0861	Integral membrane protein TerC family
AZKH_p0473	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AZKH_p0474	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AZKH_p0475	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
AZKH_p0476	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AZKH_p0477	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AZKH_p0478	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AZKH_p0479	COG0477	Major facilitator Superfamily
AZKH_p0480	COG0183	Belongs to the thiolase family
AZKH_p0481	COG1250	3-hydroxyacyl-CoA dehydrogenase
AZKH_p0486	COG1960	acyl-CoA dehydrogenase activity
AZKH_p0488	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AZKH_p0491	COG1024	Enoyl-CoA hydratase
AZKH_p0492	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_p0495	COG0410	ABC transporter
AZKH_p0501	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AZKH_p0504	COG0583	DNA-binding transcription factor activity
AZKH_p0505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AZKH_p0506	COG2814	Major facilitator Superfamily
AZKH_p0512	COG1063	alcohol dehydrogenase
AZKH_p0516	COG0686	Belongs to the AlaDH PNT family
AZKH_p0519	COG2409	Drug exporters of the RND superfamily
AZKH_p0524	COG0531	amino acid
AZKH_p0529	COG4670	ketone body catabolic process
AZKH_p0538	COG3209	COG3209 Rhs family protein
AZKH_p0542	COG0710	3-dehydroquinate dehydratase activity
AZKH_p0543	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AZKH_p0544	COG0028	Belongs to the TPP enzyme family
AZKH_p0551	COG2855	membrane
AZKH_p0560	COG2197	response regulator
AZKH_p0562	COG1924	4 iron, 4 sulfur cluster binding
AZKH_p0565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AZKH_p0571	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_p0572	COG0300	oxidoreductase activity
AZKH_p0572	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AZKH_p0572	COG4221	oxidoreductase activity
AZKH_p0572	COG3321	synthase
AZKH_p0575	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_p0576	COG1960	acyl-CoA dehydrogenase activity
AZKH_p0580	COG3909	cytochrome
AZKH_p0583	COG1013	pyruvate-flavodoxin oxidoreductase activity
AZKH_p0584	COG0674	pyruvate-flavodoxin oxidoreductase activity
AZKH_p0584	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AZKH_p0586	COG2814	Major facilitator Superfamily
AZKH_p0587	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AZKH_p0588	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AZKH_p0589	COG2855	membrane
AZKH_p0594	COG0318	PFAM AMP-dependent synthetase and ligase
AZKH_p0598	COG2175	clavaminate synthase activity
AZKH_p0599	COG3246	L-lysine catabolic process to acetate
AZKH_p0603	COG1393	Belongs to the ArsC family
AZKH_p0606	COG3852	Histidine kinase
AZKH_p0607	COG0583	DNA-binding transcription factor activity
AZKH_p0608	COG3959	Transketolase, thiamine diphosphate binding domain
AZKH_p0609	COG3958	Transketolase
AZKH_p0610	COG1028	Short-chain dehydrogenase reductase Sdr
AZKH_p0611	COG2084	Dehydrogenase
AZKH_p0612	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AZKH_p0613	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
AZKH_p0615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AZKH_p0624	COG1944	ATP diphosphatase activity
AZKH_p0625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AZKH_p0631	COG1012	belongs to the aldehyde dehydrogenase family
AZKH_p0636	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AZKH_p0637	COG0500	methyltransferase
AZKH_p0638	COG3134	Outer membrane lipoprotein
AZKH_p0641	COG4221	oxidoreductase activity
AZKH_p0645	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AZKH_p0651	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AZKH_p0652	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AZKH_p0653	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AZKH_p0654	COG1760	l-serine dehydratase
AZKH_p0655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AZKH_p0657	COG0509	glycine decarboxylation via glycine cleavage system