locus-tag class description C0099_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C0099_00015 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C0099_00050 ENOG4105CF1 Alkylated DNA repair protein C0099_00075 ENOG4107RUY (E1 component), alpha subunit C0099_00080 ENOG4105CPP Dehydrogenase, E1 component C0099_00090 ENOG4105C1G acyl-Coa dehydrogenase C0099_00095 ENOG4105DH7 May be involved in recombination (By similarity) C0099_00105 ENOG4105I08 Pseudouridine synthase C0099_00115 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C0099_00125 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C0099_00130 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C0099_00145 ENOG4108JU3 Alkyl hydroperoxide reductase C0099_00160 ENOG4105CV8 reductase C0099_00175 ENOG4105GMT ATPase associated with various cellular activities aaa_5 C0099_00180 ENOG4105FAE von Willebrand factor, type A C0099_00195 ENOG4105D82 Glutamate dehydrogenase C0099_00205 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C0099_00210 ENOG4105BZS acriflavin resistance protein C0099_00215 ENOG4105C1P efflux transporter, rnd family, mfp subunit C0099_00260 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C0099_00265 ENOG4105E0C molybdate abc transporter C0099_00270 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) C0099_00290 ENOG4105CHH sulfate transporter C0099_00300 ENOG4105DXX methyltransferase C0099_00305 ENOG4108UVJ appr-1-p processing domain protein C0099_00315 ENOG4108RWI nicotinamidase C0099_00330 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) C0099_00335 ENOG4108YZ9 Urea amidohydrolase subunit gamma C0099_00340 ENOG4105KI2 Urea amidohydrolase subunit beta C0099_00345 ENOG4105CQM Urea amidohydrolase subunit alpha C0099_00350 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) C0099_00355 ENOG4108WKG Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) C0099_00360 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) C0099_00375 ENOG41085FC arsR family transcriptional regulator C0099_00380 ENOG4108UXE Protein tyrosine phosphatase C0099_00385 ENOG4105D6J arsenicaL-resistance protein C0099_00395 ENOG4105BZU Histidine kinase C0099_00410 ENOG4105D3D Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) C0099_00425 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ C0099_00455 ENOG41080XQ Signal transduction protein with cbs domains C0099_00460 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) C0099_00465 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) C0099_00470 ENOG41060IM Heme exporter protein C0099_00480 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) C0099_00485 ENOG4105DA4 cytochrome c-type biogenesis protein C0099_00490 ENOG4107QX9 Thiol disulfide interChange protein C0099_00495 ENOG4105KWW Biogenesis protein C0099_00510 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C0099_00515 ENOG4107SDU Methyl-accepting chemotaxis C0099_00525 ENOG4105K70 DNA-binding protein C0099_00530 ENOG4107YIM Involved in the transcription termination process (By similarity) C0099_00535 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C0099_00550 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) C0099_00555 ENOG4105VF7 tolerance protein C0099_00570 ENOG41085EG Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) C0099_00575 ENOG4105WAP TPR repeat-containing protein C0099_00580 ENOG4105KME endoribonuclease L-psp C0099_00585 ENOG4105CB5 ATP-dependent DNA helicase recG C0099_00600 ENOG4105RUM Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) C0099_00605 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) C0099_00615 ENOG4105SKN orotidine 5''-phosphate decarboxylase C0099_00620 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) C0099_00645 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) C0099_00650 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase C0099_00660 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C0099_00670 ENOG4105XQ6 frataxin-like protein C0099_00675 ENOG4108JQC penicillin-binding protein 1A C0099_00700 ENOG4105E4G Type IV pilus C0099_00705 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C0099_00710 ENOG4105D49 3-dehydroquinate synthase C0099_00715 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein C0099_00745 ENOG4105C32 Amino acid ABC transporter (Permease) C0099_00750 ENOG4105C0Z ABC transporter C0099_00755 ENOG4108IV0 ABC, transporter C0099_00760 ENOG4105CHR reductase C0099_00795 ENOG4107R73 Mate efflux family protein C0099_00810 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C0099_00820 ENOG4105CEI nitrite reductase C0099_00835 ENOG4105CEI nitrite reductase C0099_00840 ENOG4107SDU Methyl-accepting chemotaxis C0099_00855 ENOG4105C2W permease C0099_00860 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C0099_00870 ENOG4105KRQ Addiction module toxin, Txe YoeB family C0099_00875 ENOG41082AG Plasmid maintenance system antidote protein C0099_00905 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving C0099_00910 ENOG4105DSY exodeoxyribonuclease V, gamma C0099_00915 ENOG4107QKA exodeoxyribonuclease V beta C0099_00920 ENOG4107QYX exodeoxyribonuclease v alpha C0099_00925 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase C0099_00935 ENOG4105CEN a g-specific adenine glycosylase C0099_00950 ENOG41089UC methyltransferase, type 11 C0099_00960 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C0099_00965 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C0099_00970 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C0099_00975 ENOG4105D07 Signal peptide peptidase, SppA C0099_00985 ENOG4105CSA Coproporphyrinogen iii oxidase C0099_00990 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C0099_00995 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) C0099_01010 ENOG4105DSJ YicC domain protein C0099_01015 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) C0099_01020 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) C0099_01025 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C0099_01030 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C0099_01035 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C0099_01045 ENOG4108UPT UPF0178 protein C0099_01060 ENOG4105MYN Zinc uptake regulation protein C0099_01065 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters C0099_01070 ENOG4105CKI cobalamin synthesis protein C0099_01075 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C0099_01110 ENOG4105BZU Histidine kinase C0099_01115 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C0099_01120 ENOG4108UQS dipeptidase C0099_01130 ENOG4108IAJ Nad-dependent epimerase dehydratase C0099_01135 ENOG4105BZ1 (ABC) transporter C0099_01155 ENOG4105C32 Amino acid ABC transporter (Permease) C0099_01160 ENOG4105CNN ABC, transporter C0099_01165 ENOG4105C0Z ABC transporter C0099_01170 ENOG4108IV0 ABC, transporter C0099_01190 ENOG4106FC9 Protein of unknown function (DUF3018) C0099_01205 ENOG4105CYM Glutathione S-transferase C0099_01210 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C0099_01215 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C0099_01225 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C0099_01230 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C0099_01245 ENOG4105VDM plasmid maintenance system antidote protein, xre family C0099_01295 ENOG4105BZU Histidine kinase C0099_01305 ENOG4105IW1 AmiS UreI transporter C0099_01315 ENOG4105DRR Transcriptional regulator, GntR family C0099_01320 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit C0099_01325 ENOG41069H7 transport system small permease component C0099_01330 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C0099_01335 ENOG4108WYP Transcriptional regulator C0099_01340 ENOG4105JN3 extra-cytoplasmic solute receptor family protein C0099_01355 ENOG4105CXK mandelate racemase muconate lactonizing C0099_01360 ENOG4105ERH Fumarylacetoacetate hydrolase C0099_01365 ENOG4108JQ1 Dehydrogenase C0099_01370 ENOG4105CXK mandelate racemase muconate lactonizing C0099_01395 ENOG4105CBG Sulfatase C0099_01405 ENOG4105DZ2 Transcriptional regulator C0099_01435 ENOG4105EGI Transcriptional regulator C0099_01440 ENOG4107QZF nitrite reductase NADPH large subunit C0099_01445 ENOG4105KPV Transcriptional regulator C0099_01450 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C0099_01455 ENOG4108IJ8 ABC transporter C0099_01470 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) C0099_01520 ENOG4105CAU Arsenical resistance protein, ArsH C0099_01530 ENOG4105C08 Histidine kinase C0099_01535 ENOG4108KXV response regulator C0099_01550 ENOG4105GR3 Histidine kinase C0099_01565 ENOG4105EQ2 LysR family Transcriptional regulator C0099_01570 ENOG4105EUB pirin domain protein C0099_01575 ENOG4105CHJ isochorismatase hydrolase C0099_01580 ENOG4105EUB pirin domain protein C0099_01590 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein C0099_01595 ENOG4105BZU Histidine kinase C0099_01600 ENOG4105K5B UPF0225 protein C0099_01610 ENOG4108YZN class I peptide chain release factor C0099_01625 ENOG4105DHG Allantoate amidinohydrolase C0099_01630 ENOG4108Z2U ureidoglycolate hydrolase C0099_01635 ENOG4107XBN GntR Family Transcriptional Regulator C0099_01640 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C0099_01645 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) C0099_01665 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C0099_01700 ENOG4105E39 Enoyl-CoA hydratase C0099_01705 ENOG4105CBP Major Facilitator C0099_01725 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) C0099_01735 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C0099_01750 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C0099_01755 ENOG4105BZU Histidine kinase C0099_01770 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C0099_01775 ENOG4105CA9 Pyruvate kinase C0099_01785 ENOG4105CFN oxalyl-CoA decarboxylase C0099_01805 ENOG4108IEG Formate dehydrogenase Alpha subunit C0099_01815 ENOG4105EKQ RNA-directed DNA polymerase C0099_01825 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C0099_01840 ENOG4107ZXU DSBA oxidoreductase C0099_01865 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C0099_01870 ENOG4107VRB Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C0099_01880 ENOG4105KCK Peptidoglycan-associated lipoprotein C0099_01885 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) C0099_01895 ENOG4105M8F Biopolymer transport protein exbD tolR C0099_01900 ENOG4105E02 MotA TolQ exbB proton channel C0099_01905 ENOG4107YD3 Thioesterase C0099_01915 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) C0099_01920 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) C0099_01940 ENOG4107QX8 SPFH domain, Band 7 family protein C0099_01955 ENOG4105EA8 2-Nitropropane dioxygenase C0099_01960 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) C0099_01965 ENOG4105EQR Transposase IS116 IS110 IS902 C0099_01990 ENOG4107R11 Transcriptional regulator C0099_01995 ENOG4107RB3 L-asparaginase C0099_02000 ENOG4108JJ7 ABC transporter C0099_02005 ENOG4107QPN acyl-Coa dehydrogenase C0099_02010 ENOG4105CHU acetyl-coa acetyltransferase C0099_02015 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C0099_02020 ENOG4105NAU thioesterase Superfamily protein C0099_02035 ENOG4108U78 Glutathione S-transferase C0099_02070 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) C0099_02075 ENOG4105EXC Acyl-transferase C0099_02080 ENOG4105C75 arginyL-tRNA synthetase C0099_02100 ENOG4105C7I Dehydrogenase C0099_02115 ENOG4105DCF alanine dehydrogenase C0099_02125 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class C0099_02140 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C0099_02155 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C0099_02175 ENOG4105D82 Glutamate dehydrogenase C0099_02195 ENOG4105BZU Histidine kinase C0099_02205 ENOG4107RNH Outer membrane receptor FepA C0099_02220 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) C0099_02230 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) C0099_02235 ENOG4108594 Permease of the drug metabolite transporter C0099_02240 ENOG4105CDY transcriptional regulatory protein C0099_02250 ENOG4105D7A ATP-binding protein C0099_02260 ENOG4105SYT Methylenetetrahydrofolate reductase C0099_02270 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C0099_02275 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C0099_02280 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) C0099_02290 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C0099_02300 ENOG4105D1S lipid A biosynthesis C0099_02305 ENOG4107W7X Aldolase C0099_02310 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) C0099_02330 ENOG4107TUY Histidine kinase C0099_02335 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C0099_02350 ENOG4105F9F transposase C0099_02380 ENOG4107QQG Dehydrogenase C0099_02385 ENOG4105KHS type IV fimbrial pilin protein C0099_02405 ENOG4107SJB teichoic acid biosynthesis C0099_02410 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase C0099_02420 ENOG4105D2T synthase C0099_02445 ENOG4105F0R Cytidylyltransferase C0099_02455 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C0099_02460 ENOG4105C5E polysaccharide biosynthesis protein C0099_02465 ENOG4105BZ1 (ABC) transporter C0099_02495 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division C0099_02515 ENOG4105C6K Malic enzyme C0099_02520 ENOG41061WM D-Alanyl-D-Alanine C0099_02525 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) C0099_02535 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C0099_02545 ENOG4105DSE periplasmic solute binding protein C0099_02550 ENOG4105CC5 ABC transporter C0099_02555 ENOG4105DIK (ABC) transporter C0099_02565 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C0099_02585 ENOG4105BZU Histidine kinase C0099_02590 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) C0099_02595 ENOG4105C7Z Conserved Protein C0099_02600 ENOG4105W2Z cytochrome C, class I C0099_02605 ENOG4105BZU Histidine kinase C0099_02610 ENOG4105BZU Histidine kinase C0099_02615 ENOG4105D58 Diguanylate phosphodiesterase C0099_02630 ENOG4108YXA Membrane C0099_02635 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C0099_02640 ENOG4105CZX twitching motility protein C0099_02645 ENOG4105CZX twitching motility protein C0099_02650 ENOG4105DFA alanine racemase domain protein C0099_02655 ENOG4105II7 pyrroline-5-carboxylate reductase C0099_02660 ENOG4108VIA integral membrane protein C0099_02665 ENOG4105EQR Transposase IS116 IS110 IS902 C0099_02670 ENOG4105CD3 dihydroorotase C0099_02675 ENOG4105CXT aspartate transcarbamylase C0099_02680 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) C0099_02685 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) C0099_02690 ENOG4108UJU UPF0301 protein C0099_02695 ENOG4105CVP deoxyribo-dipyrimidine photolyase C0099_02700 ENOG4105CBS Chea signal transduction histidine kinase C0099_02705 ENOG4105C8Q Methyl-accepting chemotaxis C0099_02715 ENOG4105M3Z response regulator C0099_02720 ENOG4108UNF response regulator C0099_02725 ENOG4105VCQ rubredoxin C0099_02730 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) C0099_02735 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C0099_02745 ENOG4105CJW magnesium transporter C0099_02750 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase C0099_02755 ENOG4105E2X shikimate dehydrogenase C0099_02780 ENOG4105IPS esterase C0099_02785 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) C0099_02795 ENOG4105BZU Histidine kinase C0099_02800 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) C0099_02805 ENOG4105DWF phosphomethylpyrimidine kinase C0099_02845 ENOG4105DJT lAO AO transport system ATPase C0099_02850 ENOG4107QX3 carboxylase C0099_02860 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C0099_02880 ENOG4105BZU Histidine kinase C0099_02915 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C0099_02925 ENOG4105PM1 preprotein translocase subunit SecE C0099_02935 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) C0099_02940 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) C0099_02945 ENOG4108VZM 50s ribosomal protein L10 C0099_02950 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) C0099_02955 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C0099_02960 ENOG4107QR0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C0099_02965 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C0099_02970 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C0099_02975 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C0099_02980 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C0099_02985 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) C0099_02990 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C0099_02995 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C0099_03000 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) C0099_03005 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C0099_03010 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) C0099_03015 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) C0099_03020 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) C0099_03025 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C0099_03030 ENOG41084PQ 50s ribosomal protein l29 C0099_03035 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C0099_03040 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) C0099_03045 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) C0099_03050 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits C0099_03055 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C0099_03060 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C0099_03065 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C0099_03070 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C0099_03075 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C0099_03080 ENOG4105VPB 50S ribosomal protein L30 C0099_03085 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C0099_03090 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C0099_03095 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) C0099_03100 ENOG41067V7 50S ribosomal protein L36 C0099_03105 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits C0099_03110 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C0099_03115 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C0099_03120 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C0099_03125 ENOG4108ZT0 50S ribosomal protein l17 C0099_03130 ENOG4105VEJ Heat shock protein C0099_03135 ENOG4105CMR udp-glucose 4-epimerase C0099_03150 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C0099_03155 ENOG4107RDB Major Facilitator C0099_03160 ENOG4108UUM single-stranded DNA-binding protein C0099_03165 ENOG4105C87 Aminotransferase class I and II C0099_03170 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) C0099_03175 ENOG4105CUZ uba thif-type nad fad binding protein C0099_03190 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) C0099_03200 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C0099_03205 ENOG4105EUB pirin domain protein C0099_03210 ENOG4108MTB glycosyl transferase family C0099_03215 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C0099_03220 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C0099_03230 ENOG4105C5I Dehydrogenase C0099_03235 ENOG4105D65 subunit l C0099_03240 ENOG4108ZE9 Monovalent cation H antiporter subunit C C0099_03245 ENOG4107R4Z monovalent cation h antiporter subunit d C0099_03250 ENOG4105SC1 monovalent cation H antiporter subunit E C0099_03255 ENOG4105W4C monovalent cation H antiporter subunit F C0099_03260 ENOG4105KJM monovalent cation h antiporter subunit g C0099_03265 ENOG4105FE9 pseudouridine synthase C0099_03270 ENOG4105D65 subunit l C0099_03275 ENOG4105MKQ Monovalent cation H antiporter subunit C C0099_03280 ENOG4108JPZ Monovalent cation H antiporter subunit D C0099_03285 ENOG4105SC1 monovalent cation H antiporter subunit E C0099_03295 ENOG4105KJM monovalent cation h antiporter subunit g C0099_03300 ENOG4105CX6 glutaminyL-tRNA synthetase C0099_03310 ENOG4105D64 Mechanosensitive ion channel C0099_03320 ENOG4105BZ8 glutamate synthase C0099_03335 ENOG4105CQ7 ATP-dependent helicase C0099_03340 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) C0099_03350 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C0099_03355 ENOG4105K9Q Binds to the 23S rRNA (By similarity) C0099_03360 ENOG4105CDU Replicative dna helicase C0099_03390 ENOG4105NWN ApaG protein C0099_03395 ENOG4107QTF adenylosuccinate lyase C0099_03405 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C0099_03410 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C0099_03415 ENOG4105VIE preprotein translocase, subunit YajC C0099_03420 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) C0099_03425 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) C0099_03440 ENOG4108MN8 Membrane C0099_03445 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) C0099_03450 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C0099_03455 ENOG4108ZXC Two component transcriptional regulator, luxr family C0099_03460 ENOG4105BZU Histidine kinase C0099_03465 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C0099_03470 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C0099_03475 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C0099_03485 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) C0099_03490 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C0099_03495 ENOG4105CUT histidyl-tRNA synthetase C0099_03500 ENOG4105N21 Membrane C0099_03505 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) C0099_03510 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C0099_03515 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C0099_03520 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C0099_03525 ENOG4107QJR hflk protein C0099_03530 ENOG4105EPW hflc protein C0099_03540 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) C0099_03545 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C0099_03555 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C0099_03560 ENOG4105C2N RNA methyltransferase TrmH family group 3 C0099_03575 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C0099_03595 ENOG4108DT4 serine threonine protein kinase C0099_03605 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit C0099_03610 ENOG4108IFG nitrite reductase, (NAD(P)H) C0099_03625 ENOG4105DHJ ABC, transporter C0099_03635 ENOG4105D0S secretion protein (HlyD C0099_03640 ENOG4105CJ1 ABC, transporter C0099_03645 ENOG4105CMI transporter C0099_03660 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C0099_03665 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) C0099_03670 ENOG4107QMP dna polymerase iii subunits gamma and tau C0099_03675 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) C0099_03680 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C0099_03685 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C0099_03690 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C0099_03695 ENOG4105EIX cytochrome c1 C0099_03700 ENOG4107MKT Stringent starvation protein a C0099_03715 ENOG4105MWK D-amino acid dehydrogenase, small subunit C0099_03720 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 C0099_03725 ENOG4105C26 Dehydrogenase C0099_03750 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C0099_03765 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) C0099_03770 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) C0099_03775 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C0099_03785 ENOG4105DHQ Histidine kinase C0099_03810 ENOG4105CVR type I restriction-modification system C0099_03815 ENOG4105EKX Restriction modification system DNA (Specificity C0099_03825 ENOG4105DZR Type I site-specific deoxyribonuclease C0099_03885 ENOG4105XJC Two component transcriptional regulator (Winged helix family C0099_03890 ENOG4105IFJ Histidine kinase C0099_03915 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) C0099_03920 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C0099_03925 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C0099_03940 ENOG4105EKQ RNA-directed DNA polymerase C0099_03950 ENOG4105CH7 arginosuccinase C0099_03955 ENOG4108HRK Histidine kinase C0099_03960 ENOG4108NEV two component transcriptional regulator, LytTR family C0099_03965 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) C0099_03975 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C0099_03980 ENOG41076E6 Uroporphyrinogen-III Synthase C0099_03985 ENOG4105ECF c-methyltransferase C0099_03995 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) C0099_04000 ENOG4105C12 Phosphoribosylglycinamide synthetase C0099_04015 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C0099_04020 ENOG4105D0A hydroxylase C0099_04025 ENOG4107RAQ aminopeptidase C0099_04030 ENOG4108S0S Nucleotidyl transferase C0099_04035 ENOG4105EHM Aminoglycoside phosphotransferase C0099_04040 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) C0099_04045 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) C0099_04050 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) C0099_04055 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C0099_04060 ENOG4105EQR Transposase IS116 IS110 IS902 C0099_04075 ENOG4107RU9 Transcriptional regulator, Crp Fnr family C0099_04085 ENOG4105DGW oligopeptidase A C0099_04100 ENOG4105C8V SAICAR synthetase C0099_04110 ENOG4105CKK Glycosyl transferase, family 2 C0099_04125 ENOG4105CDV Ompa motb domain protein C0099_04135 ENOG4105CKK Glycosyl transferase, family 2 C0099_04140 ENOG4107QN2 dihydrolipoyl dehydrogenase C0099_04175 ENOG4108WQI RNA Polymerase C0099_04180 ENOG4105C9Q fumarate hydratase class II C0099_04185 ENOG4105D8X mechanosensitive ion channel C0099_04200 ENOG4105BZA Phosphoglycerate kinase C0099_04205 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C0099_04210 ENOG4105CV1 Transketolase (EC 2.2.1.1) C0099_04220 ENOG4105ECY inositol monophosphatase C0099_04225 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C0099_04230 ENOG4108EKC n-acetylglutamate synthase C0099_04235 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) C0099_04240 ENOG4108UTW Plays a role in the regulation of phosphate uptake C0099_04245 ENOG4105E66 phosphoriboisomerase A C0099_04250 ENOG4105CVM Molybdenum cofactor synthesis domain protein C0099_04255 ENOG4105ED9 Protein of unknown function (DUF455) C0099_04265 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) C0099_04270 ENOG4105D52 delta-aminolevulinic acid dehydratase C0099_04280 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C0099_04285 ENOG4105MJ2 Competence protein C0099_04290 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C0099_04295 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C0099_04305 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) C0099_04310 ENOG4105VW4 glutaredoxin 3 C0099_04315 ENOG4107YZP Rhodanese domain protein C0099_04320 ENOG41080HT Transcriptional regulator, arsr family C0099_04325 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C0099_04335 ENOG4105CN1 protease C0099_04345 ENOG4105D06 uba thif-type nad fad binding protein C0099_04355 ENOG4105CEY Amp-dependent synthetase and ligase C0099_04365 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase C0099_04370 ENOG4105C11 sulfate adenylyltransferase), subunit 2 C0099_04380 ENOG4105CAS nag kinase C0099_04385 ENOG4105C6Y Udp-glucose 6-dehydrogenase C0099_04390 ENOG4108TIT dATP pyrophosphohydrolase C0099_04405 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C0099_04410 ENOG4105C9M aspartyl-trna synthetase C0099_04420 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) C0099_04430 ENOG4107QHF type ii secretion system protein e C0099_04435 ENOG4108JU6 CBS domain protein C0099_04445 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY C0099_04465 ENOG4108UYE Lactoylglutathione lyase C0099_04475 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C0099_04490 ENOG4105VCC 30S ribosomal protein S21 C0099_04495 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C0099_04500 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C0099_04510 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS C0099_04520 ENOG4105F9F transposase C0099_04530 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C0099_04535 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C0099_04540 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) C0099_04545 ENOG4105DJF DNA polymerase III, delta' subunit C0099_04555 ENOG4105C8T Leucyl-tRNA synthetase C0099_04560 ENOG4105C4R Atp-dependent dna helicase C0099_04565 ENOG4105BZU Histidine kinase C0099_04570 ENOG4107QJE Chromosome Partitioning Protein C0099_04575 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein C0099_04580 ENOG4105C0B DNA polymerase III (alpha subunit) C0099_04585 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 C0099_04590 ENOG4105CHH sulfate transporter C0099_04595 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C0099_04605 ENOG4105DHP deoxycytidine triphosphate deaminase C0099_04610 ENOG4105CXN decarboxylase C0099_04620 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) C0099_04650 ENOG41080IJ Diacylglycerol kinase C0099_04655 ENOG4105BZF Glycosyl transferase (Group 1 C0099_04665 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family C0099_04670 ENOG4105T95 Thiol disulfide interChange protein C0099_04675 ENOG4105CA3 membrane-bound lytic murein transglycosylase C0099_04685 ENOG4105M6F mutator MutT protein C0099_04690 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) C0099_04695 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) C0099_04700 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C0099_04710 ENOG4108194 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) C0099_04715 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase C0099_04720 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C0099_04725 ENOG4105CUX Signal transduction histidine kinase C0099_04735 ENOG4105C5F glutamine synthetase C0099_04750 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C0099_04755 ENOG4105X23 Endonuclease Exonuclease phosphatase C0099_04760 ENOG4105DZQ phospholipase D Transphosphatidylase C0099_04765 ENOG4105K4P CoA-binding domain protein C0099_04770 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) C0099_04775 ENOG4105C3G gtp-binding protein C0099_04780 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C0099_04785 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C0099_04790 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C0099_04800 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C0099_04805 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) C0099_04810 ENOG4105DJQ tetratricopeptide tpr_2 repeat protein C0099_04815 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C0099_04825 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding C0099_04830 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C0099_04835 ENOG4106H78 methyltransferase C0099_04840 ENOG4105C1V Peptidase, M16 C0099_04855 ENOG4105CAK Cell division ATP-binding protein ftsE C0099_04860 ENOG4105CRP Part of the ABC transporter FtsEX involved in C0099_04870 ENOG4108Z6B deaminase C0099_04880 ENOG41082BV acetyltransferase C0099_04895 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) C0099_04900 ENOG4105HHA aminodeoxychorismate lyase C0099_04905 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C0099_04910 ENOG4107QRG dna polymerase iii C0099_04920 ENOG4105F8V Hydrolase, tatD family C0099_04930 ENOG4105CH2 amidohydrolase C0099_04935 ENOG4105CV6 ABC transporter, permease C0099_04940 ENOG4108ESY Metal dependent phosphohydrolase C0099_04950 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C0099_04955 ENOG4105DAN ATP-dependent protease C0099_04960 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) C0099_04985 ENOG4105IQ5 FAD linked oxidase domain protein C0099_05020 ENOG4105CGF Aromatic amino acid aminotransferase C0099_05025 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C0099_05030 ENOG4105KJF protein tyrosine phosphatase C0099_05040 ENOG4105CH5 extracellular solute-binding protein, family 7 C0099_05050 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C0099_05055 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C0099_05060 ENOG4105C03 ribonuclease C0099_05065 ENOG4105EI2 Pseudouridine synthase C0099_05070 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C0099_05075 ENOG4108UHJ MAF-like protein C0099_05080 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein C0099_05085 ENOG4105VGS 50s ribosomal protein l32 C0099_05090 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) C0099_05095 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C0099_05100 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C0099_05105 ENOG4105CHR reductase C0099_05110 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C0099_05115 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C0099_05125 ENOG4108IYU L-aspartate oxidase C0099_05130 ENOG4105EMN RNA polymerase sigma factor C0099_05150 ENOG4105C0H protease C0099_05160 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C0099_05165 ENOG4105C3F Signal peptidase i C0099_05175 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C0099_05180 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C0099_05185 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) C0099_05190 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) C0099_05195 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) C0099_05200 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) C0099_05205 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C0099_05210 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C0099_05215 ENOG4105BZU Histidine kinase C0099_05225 ENOG4105BZU Histidine kinase C0099_05230 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) C0099_05235 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region C0099_05240 ENOG4107RD7 Flagellar Motor Protein, MotA C0099_05245 ENOG4105ER2 Ompa motb domain protein C0099_05250 ENOG4105BZU Histidine kinase C0099_05255 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C0099_05260 ENOG4107R88 Chemotaxis protein (CheV) C0099_05265 ENOG4107R88 Chemotaxis protein (CheV) C0099_05270 ENOG4108VYJ response regulator receiver protein C0099_05275 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) C0099_05280 ENOG4105CBS Chea signal transduction histidine kinase C0099_05285 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) C0099_05290 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C0099_05295 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C0099_05320 ENOG4109015 Biopolymer transport protein exbD tolR C0099_05325 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) C0099_05330 ENOG4105W49 UPF0434 protein C0099_05335 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) C0099_05340 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C0099_05350 ENOG4105E0M Sulfatase C0099_05360 ENOG4105C94 Transporter C0099_05370 ENOG4105C94 Transporter C0099_05375 ENOG4105D7N magnesium and cobalt transport protein CorA C0099_05380 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C0099_05385 ENOG4105ERG peptidase m48, ste24p C0099_05390 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) C0099_05395 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C0099_05400 ENOG4105FQR PH-inducible protein involved in stress response C0099_05415 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C0099_05420 ENOG4108M8S permease YjgP YjgQ family protein C0099_05430 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) C0099_05435 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C0099_05440 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) C0099_05445 ENOG4105K5M 30s ribosomal protein S16 C0099_05450 ENOG4105CS1 NAD(P)H quinone oxidoreductase C0099_05460 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C0099_05465 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C0099_05470 ENOG4108ZP8 Acetolactate synthase small subunit C0099_05475 ENOG4105C7K acetolactate synthase C0099_05480 ENOG4105VQU rdd domain containing protein C0099_05490 ENOG4105CD8 aminopeptidase N C0099_05500 ENOG4108JU3 Alkyl hydroperoxide reductase C0099_05520 ENOG4105E2B Taurine dioxygenase C0099_05525 ENOG4105W8I Transcriptional regulator C0099_05535 ENOG4107SDU Methyl-accepting chemotaxis C0099_05540 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) C0099_05545 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C0099_05555 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C0099_05560 ENOG4105DJ0 Poly(A) Polymerase C0099_05570 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) C0099_05575 ENOG4105C02 permease C0099_05580 ENOG4105CXB phosphoribosylaminoimidazole synthetase C0099_05585 ENOG4105E1F short-chain dehydrogenase reductase C0099_05600 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C0099_05605 ENOG4108UM1 dedA family C0099_05620 ENOG4108I9X Isocitrate lyase C0099_05625 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C0099_05640 ENOG4108ZK4 sdia-regulated domain-containing protein C0099_05655 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C0099_05680 ENOG4105F9F transposase C0099_05695 ENOG4105F9F transposase C0099_05715 ENOG4105DDY UPF0142 protein ycaO C0099_05720 ENOG4105C1G acyl-Coa dehydrogenase C0099_05735 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C0099_05755 ENOG4105BZU Histidine kinase C0099_05760 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C0099_05765 ENOG4105E0X reductase C0099_05780 ENOG4108ZJF Glcg protein C0099_05790 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) C0099_05795 ENOG41060W2 glyoxylate carboligase C0099_05800 ENOG4105EJC lysr family transcriptional regulator C0099_05815 ENOG4108Q5Y Membrane C0099_05820 ENOG4105CH5 extracellular solute-binding protein, family 7 C0099_05830 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C0099_05835 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C0099_05840 ENOG4105VEQ Cold shock protein C0099_05845 ENOG4105CAF HipA N-terminal domain protein C0099_05860 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C0099_05865 ENOG4105C9A Phoh family C0099_05870 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C0099_05875 ENOG4108JU5 Magnesium and cobalt efflux protein C0099_05880 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) C0099_05885 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit C0099_05890 ENOG4105C38 Glycyl-tRNA synthetase beta subunit C0099_05895 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase C0099_05900 ENOG4105E9Q Acyl-transferase C0099_05915 ENOG4105E39 Enoyl-CoA hydratase C0099_05930 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase C0099_05935 ENOG4105C2X Arabinose 5-phosphate isomerase C0099_05940 ENOG4105DHJ ABC, transporter C0099_05945 ENOG4105CY3 ABC transporter, permease C0099_05950 ENOG4107PE3 Mammalian cell entry related domain protein C0099_05960 ENOG4105E3I toluene tolerance C0099_05970 ENOG4105DA5 (ABC) transporter C0099_05975 ENOG4105E3A (ABC) transporter C0099_05985 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C0099_05990 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C0099_05995 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C0099_06000 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C0099_06010 ENOG4105EKQ RNA-directed DNA polymerase C0099_06015 ENOG4105CIH Imidazole acetol-phosphate transaminase C0099_06020 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C0099_06025 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C0099_06030 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C0099_06035 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C0099_06040 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C0099_06045 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase C0099_06050 ENOG4105K59 histidine triad (HIT) protein C0099_06055 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C0099_06060 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) C0099_06065 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C0099_06070 ENOG4105C0H protease C0099_06075 ENOG4107QNR UPF0135 protein C0099_06080 ENOG4105CMV Succinyl-CoA synthetase subunit beta C0099_06085 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C0099_06090 ENOG4108UW8 fha domain-containing protein C0099_06095 ENOG4107YM4 Beta-lactamase domain-containing protein C0099_06100 ENOG4105DJV ribulose-phosphate 3-epimerase C0099_06105 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C0099_06110 ENOG4105CRQ synthase (Component I) C0099_06115 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C0099_06125 ENOG4105DDQ anthranilate synthase C0099_06130 ENOG4107QYG anthranilate phosphoribosyltransferase C0099_06135 ENOG4105DK0 Indole-3-glycerol phosphate synthase C0099_06145 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C0099_06150 ENOG4105C9U ATP-dependent DNA helicase RecQ C0099_06160 ENOG4107Z67 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) C0099_06165 ENOG4108XDN Transcriptional regulator C0099_06185 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C0099_06205 ENOG4108IXY short-chain dehydrogenase reductase C0099_06215 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) C0099_06220 ENOG4105BZ9 Cytochrome C oxidase, subunit I C0099_06225 ENOG4105FT1 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) C0099_06235 ENOG4107QS1 Cytochrome C Oxidase, Subunit III C0099_06255 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) C0099_06260 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C0099_06265 ENOG4108ZX6 Electron transport protein SCO1 SenC C0099_06275 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C0099_06280 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) C0099_06285 ENOG4105UYK outer membrane protein a C0099_06290 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) C0099_06295 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C0099_06300 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C0099_06310 ENOG4105CIH Imidazole acetol-phosphate transaminase C0099_06320 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C0099_06325 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C0099_06330 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) C0099_06340 ENOG4105CFV Tetratricopeptide repeat protein C0099_06345 ENOG4105C6T cysteine synthase C0099_06375 ENOG4105C22 threonyL-tRNA synthetase C0099_06380 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C0099_06385 ENOG4105VJV 50s ribosomal protein L35 C0099_06390 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C0099_06395 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C0099_06400 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C0099_06405 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) C0099_06420 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C0099_06425 ENOG4105DRP amino acid AbC transporter C0099_06445 ENOG4105E5Q amino acid AbC transporter C0099_06450 ENOG4105CDA abc transporter atp-binding protein C0099_06455 ENOG4105E5Q amino acid AbC transporter C0099_06465 ENOG4108R5S membrane C0099_06485 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C0099_06490 ENOG4108IRC dna polymerase iii C0099_06495 ENOG4107QN1 sodium solute C0099_06505 ENOG4105CJW magnesium transporter C0099_06510 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C0099_06510 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C0099_06515 ENOG4105BZU Histidine kinase C0099_06525 ENOG4105BZU Histidine kinase C0099_06535 ENOG4108V1U phospholipid-binding protein C0099_06540 ENOG4107QN2 dihydrolipoyl dehydrogenase C0099_06545 ENOG4107QSN dihydrolipoamide acetyltransferase C0099_06550 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) C0099_06555 ENOG4105BZU Histidine kinase C0099_06560 ENOG4108ZXC Two component transcriptional regulator, luxr family C0099_06570 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C0099_06575 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C0099_06580 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C0099_06585 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C0099_06625 ENOG4108C33 Resolvase C0099_06665 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C0099_06670 ENOG4108X4D Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) C0099_06690 ENOG4105DUM transcriptional regulator, lysR family C0099_06750 ENOG4105XJC Two component transcriptional regulator (Winged helix family C0099_06755 ENOG4105IFJ Histidine kinase C0099_06810 ENOG41080HT Transcriptional regulator, arsr family C0099_06820 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C0099_06825 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) C0099_06830 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C0099_06835 ENOG4105CH5 extracellular solute-binding protein, family 7 C0099_06840 ENOG4105CH5 extracellular solute-binding protein, family 7 C0099_06845 ENOG4105CVJ phosphoglycerate mutase C0099_06850 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C0099_06860 ENOG4105CMS peptidase U62, modulator of DNA gyrase C0099_06865 ENOG4105N42 UPF0307 protein C0099_06870 ENOG4108RIR Molybdenum cofactor biosynthesis protein C0099_06875 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C0099_06890 ENOG4108WBT adenosyltransferase C0099_06895 ENOG4105US7 Histidine kinase C0099_06905 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C0099_06920 ENOG4105DNZ Alpha Beta Hydrolase C0099_06925 ENOG4105CM2 brancheD-chain amino acid aminotransferase C0099_06930 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C0099_06940 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) C0099_06945 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C0099_06950 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C0099_06955 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C0099_06960 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) C0099_06980 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C0099_07005 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) C0099_07020 ENOG4105D1U peptidase U62 modulator of DNA gyrase C0099_07030 ENOG4105E4C Lytic transglycosylase catalytic C0099_07035 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C0099_07040 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) C0099_07050 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) C0099_07055 ENOG4108UKZ OsmC family C0099_07060 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C0099_07065 ENOG4108UJD 30S ribosomal protein S9 C0099_07070 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C0099_07075 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C0099_07080 ENOG4105DR5 peptidase C0099_07085 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C0099_07120 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C0099_07125 ENOG4105K63 Thioredoxin C0099_07130 ENOG4108Z4U Ferredoxin C0099_07140 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C0099_07145 ENOG4105D8G Major Facilitator superfamily C0099_07150 ENOG4105ERG peptidase m48, ste24p C0099_07155 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C0099_07165 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C0099_07170 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C0099_07190 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C0099_07195 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase C0099_07200 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C0099_07205 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) C0099_07210 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) C0099_07215 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C0099_07230 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase C0099_07235 ENOG4105C28 cystathionine C0099_07240 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) C0099_07245 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) C0099_07250 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) C0099_07255 ENOG4105C8N cysteinyl-tRNA synthetase C0099_07265 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C0099_07270 ENOG4105CFG Acts as a chaperone (By similarity) C0099_07275 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C0099_07280 ENOG4105D9P serine threonine protein kinase C0099_07290 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C0099_07295 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) C0099_07300 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C0099_07305 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C0099_07310 ENOG41090R7 Ferric uptake C0099_07315 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) C0099_07320 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C0099_07330 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C0099_07335 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C0099_07345 ENOG4105HBR Rna-binding protein C0099_07350 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) C0099_07355 ENOG4107ZXU DSBA oxidoreductase C0099_07365 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C0099_07370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C0099_07375 ENOG4105EEI dihydropteroate synthase C0099_07380 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C0099_07390 ENOG4105C8U phosphate abc transporter C0099_07395 ENOG4105C8U phosphate abc transporter C0099_07400 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C0099_07405 ENOG4105CP7 Triose-phosphate isomerase C0099_07410 ENOG4107EJC Preprotein translocase subunit SecG C0099_07425 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C0099_07430 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) C0099_07435 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C0099_07440 ENOG4105CE9 30S ribosomal protein S2 C0099_07445 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) C0099_07450 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) C0099_07455 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C0099_07460 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C0099_07465 ENOG4105KNE Phosphatidate cytidylyltransferase C0099_07470 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) C0099_07475 ENOG4105DZP Membrane-associated zinc metalloprotease C0099_07480 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane C0099_07490 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C0099_07495 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C0099_07500 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C0099_07505 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C0099_07510 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C0099_07520 ENOG4108RWN rrna methyltransferase C0099_07525 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C0099_07535 ENOG4105DB7 PHP domain protein C0099_07540 ENOG4107RTD sua5 ycio yrdc ywlc family protein C0099_07550 ENOG4105C31 Tryptophanyl-tRNA synthetase C0099_07555 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) C0099_07560 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C0099_07565 ENOG4105FE9 pseudouridine synthase C0099_07570 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) C0099_07575 ENOG4105CHV Transcription elongation factor NusA C0099_07580 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) C0099_07585 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) C0099_07590 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C0099_07595 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C0099_07600 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C0099_07610 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters C0099_07680 ENOG4108Z6K Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity) C0099_07685 ENOG4108JPW Aminotransferase C0099_07690 ENOG4108Z24 l-2,4-diaminobutyric acid acetyltransferase C0099_07700 ENOG4105DJB Major Facilitator Superfamily C0099_07705 ENOG4105CBX hi0933 family C0099_07710 ENOG4105KZX Pterin carbinolamine dehydratase C0099_07725 ENOG4105C0B DNA polymerase III (alpha subunit) C0099_07740 ENOG4105EKQ RNA-directed DNA polymerase C0099_07760 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C0099_07765 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C0099_07770 ENOG4108YZY peptidylprolyl cis-trans isomerase C0099_07780 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) C0099_07785 ENOG4105D1A Methyltransferase C0099_07790 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C0099_07795 ENOG4107RZZ dna polymerase iii epsilon subunit C0099_07805 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) C0099_07810 ENOG4105ECY inositol monophosphatase C0099_07820 ENOG4105D7W serine acetyltransferase C0099_07825 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family C0099_07835 ENOG4105C3J Cysteine desulfurase C0099_07840 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins C0099_07850 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) C0099_07855 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB C0099_07860 ENOG4108ZIT Ferredoxin, 2FE-2S C0099_07865 ENOG4105WVQ Fe-S assembly protein IscX C0099_07875 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) C0099_07880 ENOG4105CZX twitching motility protein C0099_07885 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) C0099_07895 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C0099_07905 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C0099_07910 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C0099_07920 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) C0099_07925 ENOG41067HS methyltransferase C0099_07935 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C0099_07945 ENOG4108UN4 phage SPO1 DNA polymerase-related protein C0099_07955 ENOG41072GX Peptidase M22 Glycoprotease C0099_07965 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C0099_07970 ENOG4105E0F Histidine kinase C0099_07980 ENOG4105K9H YciI-like protein C0099_08000 ENOG4105C10 Electron transfer flavoprotein C0099_08005 ENOG4105BZJ Electron transfer flavoprotein C0099_08010 ENOG4105EYA deoxyribonuclease C0099_08015 ENOG4105C9X ppx gppa phosphatase C0099_08025 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C0099_08045 ENOG41081HM 2'-5' rna ligase C0099_08050 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C0099_08055 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C0099_08060 ENOG41074MP UPF0103 Mediator of ErbB2-driven cell motility-containing protein C0099_08065 ENOG4105NBF ammecr1 domain protein C0099_08085 ENOG4108JA2 transcriptioN-repair coupling factor C0099_08090 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) C0099_08095 ENOG4105EAC phosphoserine phosphatase C0099_08100 ENOG4105D1Q UPF0246 protein C0099_08110 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C0099_08115 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) C0099_08120 ENOG4106T9E Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C0099_08125 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) C0099_08130 ENOG4105C8P )-transporter C0099_08145 ENOG4105BZU Histidine kinase C0099_08170 ENOG4105YES addiction module antidote protein C0099_08175 ENOG4105VUH addiction module killer protein C0099_08180 ENOG4105BZ1 (ABC) transporter C0099_08190 ENOG4107QJZ Glycosyl transferase, family 2 C0099_08205 ENOG4105C5H ABC transporter C0099_08215 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C0099_08220 ENOG4105KQ5 peptidylprolyl cis-trans isomerase C0099_08225 ENOG4105K89 arsenate reductase C0099_08235 ENOG4105TMB Formate nitrite transporter C0099_08265 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C0099_08270 ENOG4107QHQ amino acid C0099_08280 ENOG4105D8V Glucose sorbosone dehydrogenase C0099_08300 ENOG4105WKW Pfam:DUF1458 C0099_08305 ENOG4107QVT Binding-protein-dependent transport systems, inner membrane component C0099_08310 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C0099_08315 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) C0099_08320 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate C0099_08325 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) C0099_08330 ENOG4105DGN Electron transport complex C0099_08335 ENOG4108R3D Electron transport complex C0099_08340 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) C0099_08345 ENOG4105D6A Electron transport complex C0099_08350 ENOG4108UQQ Electron transport complex C0099_08360 ENOG4105CSM endonuclease III C0099_08365 ENOG4108V0P LemA family C0099_08370 ENOG4105D0M Protease HtpX homolog C0099_08375 ENOG4105N7H Cytochrome C0099_08385 ENOG4105D58 Diguanylate phosphodiesterase C0099_08395 ENOG4105CMQ Chloride channel C0099_08400 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) C0099_08405 ENOG4108RRZ Transcription elongation factor GreB C0099_08430 ENOG4105PGM cation diffusion facilitator family transporter C0099_08435 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C0099_08450 ENOG4105BZU Histidine kinase C0099_08460 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C0099_08465 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) C0099_08470 ENOG4108YXU transcriptional regulator AsnC family C0099_08480 ENOG4105EYW Ion transport protein C0099_08490 ENOG4105CSR polyphosphate kinase 2 C0099_08495 ENOG41069P5 Protein slyX homolog C0099_08520 ENOG4105BZU Histidine kinase C0099_08525 ENOG4105BZU Histidine kinase C0099_08530 ENOG4105BZU Histidine kinase C0099_08540 ENOG4105DJ4 phosphatidylserine decarboxylase C0099_08550 ENOG4108KU3 Integrase C0099_08595 ENOG4105XPQ lipid carrier protein C0099_08600 ENOG4106RZ4 Peptidase U32 C0099_08605 ENOG4105CFP Peptidase U32 C0099_08610 ENOG4105WH1 Two component transcriptional regulator luxr family C0099_08615 ENOG4105BZU Histidine kinase C0099_08620 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) C0099_08625 ENOG4105D0D Nitrate reductase 2, gamma subunit C0099_08630 ENOG4105R3A Nitrate reductase C0099_08635 ENOG4108IUE nitrate reductase beta subunit C0099_08640 ENOG4105CRU nitrate reductase, alpha subunit C0099_08645 ENOG4105DQQ Major facilitator superfamily MFS_1 C0099_08675 ENOG4107SDU Methyl-accepting chemotaxis C0099_08680 ENOG4105BZU Histidine kinase C0099_08685 ENOG4105BZU Histidine kinase C0099_08695 ENOG4108T0W nitrous oxide maturation protein NosY C0099_08700 ENOG4105CIG ABC transporter C0099_08750 ENOG4105NSG hemerythrin hhe cation binding domain protein C0099_08755 ENOG4108YY7 Invasion gene expression up-regulator SirB C0099_08775 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C0099_08780 ENOG4105FE1 phytoene synthase C0099_08790 ENOG4107S11 squalene-associated FAD-dependent desaturase C0099_08800 ENOG4105KPV Transcriptional regulator C0099_08805 ENOG4108VKQ nitriC oxide reductase C0099_08815 ENOG4105GMT ATPase associated with various cellular activities aaa_5 C0099_08820 ENOG4105FAE von Willebrand factor, type A C0099_08840 ENOG4108I0Y (ABC) transporter C0099_08860 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) C0099_08870 ENOG4105C26 Dehydrogenase C0099_08875 ENOG4105CD5 CoA-binding domain protein C0099_08885 ENOG4105BZM domain protein C0099_08890 ENOG4105KUZ arsenate reductase C0099_08900 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) C0099_08905 ENOG4107QMS site-determining protein C0099_08910 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) C0099_08915 ENOG4105CRK lysyL-tRNA synthetase C0099_08920 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) C0099_08925 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C0099_08945 ENOG4108JPW Aminotransferase C0099_08960 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C0099_08965 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C0099_08970 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C0099_08975 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C0099_08980 ENOG4105CYN Serine protein kinase C0099_08985 ENOG4106AKX UPF0229 protein C0099_08990 ENOG4105ED1 spovr family C0099_08995 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) C0099_09000 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C0099_09015 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) C0099_09020 ENOG4105D6E homoserine dehydrogenase C0099_09025 ENOG4105CHM Aminotransferase C0099_09035 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C0099_09040 ENOG4108IAB Phoh family C0099_09065 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) C0099_09085 ENOG4105C37 (CBS) domain C0099_09090 ENOG4108VWS Yaeq family C0099_09100 ENOG4105E27 serine threonine protein kinase C0099_09105 ENOG4105EUJ GTP cyclohydrolase i C0099_09115 ENOG4105CJ3 phosphate transporter C0099_09125 ENOG4105D6S protein involved in catabolism of external DNA C0099_09130 ENOG4108Z0R Transferase C0099_09145 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) C0099_09150 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) C0099_09155 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C0099_09160 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C0099_09165 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C0099_09180 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C0099_09185 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase C0099_09190 ENOG41080T7 secreted protein C0099_09210 ENOG4107QIK phosphoribosylformylglycinamidine synthase C0099_09225 ENOG4105DR5 peptidase C0099_09235 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C0099_09245 ENOG4105E0X reductase C0099_09250 ENOG4108EC8 DNA internalization-related competence protein ComEC C0099_09260 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) C0099_09265 ENOG4105D60 lipoprotein releasing system transmembrane protein C0099_09270 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C0099_09275 ENOG4105EIF outer membrane protein W C0099_09280 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) C0099_09285 ENOG4108VKQ nitriC oxide reductase C0099_09305 ENOG4105GMT ATPase associated with various cellular activities aaa_5 C0099_09320 ENOG4105FAE von Willebrand factor, type A C0099_09325 ENOG4105C1J atp-dependent rna helicase C0099_09330 ENOG4105BZU Histidine kinase C0099_09340 ENOG4105DVT helicase C0099_09350 ENOG4105YES addiction module antidote protein C0099_09355 ENOG4105VUH addiction module killer protein C0099_09360 ENOG4105D6Z AFG1 family ATPase C0099_09365 ENOG4107QN2 dihydrolipoyl dehydrogenase C0099_09370 ENOG4105C7S Dehydrogenase C0099_09375 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 C0099_09380 ENOG4105BZN citrate synthase C0099_09385 ENOG410681N tpr repeat protein C0099_09390 ENOG4105E33 succinate dehydrogenase C0099_09410 ENOG4105FDP GntR family transcriptional regulator C0099_09415 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C0099_09425 ENOG4108QER Adenylate cyclase C0099_09430 ENOG4107QIJ Aconitate hydratase 2 C0099_09435 ENOG4105KDC 50s ribosomal protein l28 C0099_09440 ENOG4105W0E 50S ribosomal protein L33 C0099_09445 ENOG4105VEQ Cold shock protein C0099_09450 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) C0099_09460 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C0099_09465 ENOG4105CBS Chea signal transduction histidine kinase C0099_09480 ENOG4105C5H ABC transporter C0099_09520 ENOG4105CQB FAD linked oxidase domain protein C0099_09525 ENOG4105D78 K07001 NTE family protein C0099_09530 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) C0099_09545 ENOG4105CHR reductase C0099_09550 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class C0099_09560 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C0099_09565 ENOG4105C34 Pseudouridine synthase C0099_09580 ENOG4105C26 Dehydrogenase C0099_09590 ENOG4105C4W S-formylglutathione hydrolase C0099_09595 ENOG4105BZU Histidine kinase C0099_09600 ENOG4105EN6 Membrane C0099_09615 ENOG4105CFH Aspartokinase C0099_09625 ENOG4107XVI synthase C0099_09650 ENOG4108V3E phosphoribosylglycinamide formyltransferase C0099_09660 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C0099_09670 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C0099_09680 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C0099_09685 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) C0099_09690 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C0099_09695 ENOG4105N1F Hnh endonuclease C0099_09705 ENOG4105J0Q Transcriptional regulator C0099_09720 ENOG4105DHQ Histidine kinase C0099_09725 ENOG4105XJC Two component transcriptional regulator (Winged helix family C0099_09745 ENOG4105CEY Amp-dependent synthetase and ligase C0099_09755 ENOG4105CHP RNA polymerase C0099_09760 ENOG4105GRZ Ycii-related protein C0099_09765 ENOG4105VRT cytoplasmic protein C0099_09770 ENOG4108R4R Iron-regulated virulence regulatory protein C0099_09780 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b C0099_09790 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase C0099_09810 ENOG4105BZU Histidine kinase C0099_09815 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C0099_09825 ENOG4107QM5 aconitate hydratase C0099_09830 ENOG4105DEN Luciferase family C0099_09845 ENOG4105C7K acetolactate synthase C0099_09860 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) C0099_09865 ENOG4105C26 Dehydrogenase C0099_09870 ENOG4105XRQ Xanthine dehydrogenase accessory factor C0099_09875 ENOG4105E39 Enoyl-CoA hydratase C0099_09900 ENOG4106HBX Transcriptional Regulator AraC Family C0099_09930 ENOG4105VYA Uncharacterized conserved protein (DUF2132) C0099_09970 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) C0099_09975 ENOG4108JJ8 (ABC) transporter C0099_09980 ENOG4108JJ9 ABC, transporter C0099_09985 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C0099_09990 ENOG4105C4M (Ubiquinol oxidase) subunit I C0099_10015 ENOG4105DXI Major Facilitator superfamily C0099_10020 ENOG41082J7 Rhodanese domain protein C0099_10060 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C0099_10100 ENOG4105D6J arsenicaL-resistance protein C0099_10160 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C0099_10165 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C0099_10175 ENOG4105VDB UPF0125 protein C0099_10180 ENOG4108Z1B Cyclase dehydrase C0099_10185 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C0099_10195 ENOG4105CNG UPF0061 protein C0099_10200 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C0099_10205 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C0099_10210 ENOG4105BZU Histidine kinase C0099_10215 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C0099_10225 ENOG4108ZAF Molybdopterin C0099_10230 ENOG4105M00 molybdopterin converting factor, subunit 1 C0099_10235 ENOG4105CVM Molybdenum cofactor synthesis domain protein C0099_10240 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b C0099_10245 ENOG4108YYQ gCN5-related N-acetyltransferase C0099_10250 ENOG4107S2Z UPF0761 membrane protein C0099_10265 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C0099_10270 ENOG4105EJC lysr family transcriptional regulator C0099_10280 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C0099_10290 ENOG4105CH5 extracellular solute-binding protein, family 7 C0099_10330 ENOG4105E18 UPF0276 protein C0099_10385 ENOG41084KP 4-oxalocrotonate tautomerase C0099_10405 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) C0099_10435 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C0099_10450 ENOG4105CVE Lytic murein transglycosylase C0099_10465 ENOG4105E2K Glycosyl transferase (Group 1 C0099_10490 ENOG4105BZU Histidine kinase C0099_10505 ENOG4105BZU Histidine kinase C0099_10520 ENOG4105EYH Exonuclease C0099_10555 ENOG4105EN6 Membrane C0099_10560 ENOG4105BZU Histidine kinase C0099_10585 ENOG4105BZU Histidine kinase C0099_10590 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C0099_10595 ENOG4105BZU Histidine kinase C0099_10615 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C0099_10620 ENOG4105D1H recombination factor protein RarA C0099_10625 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) C0099_10630 ENOG4105CNU cell division protein FtsK C0099_10635 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for C0099_10640 ENOG4105F0N pyrophosphate phospho-hydrolase C0099_10645 ENOG4107RYR Transcriptional regulator, Crp Fnr family C0099_10650 ENOG4105C3M thioredoxin reductase C0099_10660 ENOG4108YZA Nitrogen regulatory protein pii C0099_10665 ENOG4105C4K Nad synthetase C0099_10690 ENOG4105D4P Coproporphyrinogen iii oxidase C0099_10695 ENOG4105DS0 Transcriptional regulator, Crp Fnr family C0099_10700 ENOG4105CY0 Metallo-Beta-Lactamase C0099_10725 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) C0099_10740 ENOG4105EUH cytochrome C oxidase, cbb3-type, subunit i C0099_10750 ENOG4105C59 p-type ATPase C0099_10755 ENOG4108WYP Transcriptional regulator C0099_10760 ENOG41085JF Trap dicarboxylate transporter-dctp subunit C0099_10770 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C0099_10795 ENOG41065ZS Transfers 2'-(5-triphosphoribosyl)-3'-dephosphocoenzyme- A to the apo- acyl-carrier-protein of the malonate decarboxylase to yield holo- acyl-carrier-protein (By similarity) C0099_10800 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase C0099_10810 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein C0099_10815 ENOG4107SDU Methyl-accepting chemotaxis C0099_10865 ENOG4107SKI cobyrinic Acid a,c-diamide synthase C0099_10895 ENOG4106AXJ AraC family transcriptional regulator C0099_10920 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) C0099_10935 ENOG4105NVB glycoside hydrolase, family 19 C0099_11115 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C0099_11230 ENOG4107QP3 malate synthase g C0099_11245 ENOG4105C5R Aminotransferase C0099_11250 ENOG4105E9K Isocitrate dehydrogenase C0099_11255 ENOG4105CGH 5'-nucleotidase C0099_11260 ENOG4108XRS Monoheme cytochrome SoxX (Sulfur oxidation) C0099_11280 ENOG4105W2Z cytochrome C, class I C0099_11285 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) C0099_11290 ENOG4107YCR Transcriptional regulator, ARSR family C0099_11300 ENOG4107S7U Sulfide dehydrogenase C0099_11315 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C0099_11320 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C0099_11325 ENOG4105W5Q DNA repair protein (RadC C0099_11335 ENOG4105WQ3 Rna-binding protein C0099_11345 ENOG4105PI0 Ferredoxin C0099_11355 ENOG4106RHG Yeca family C0099_11360 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C0099_11365 ENOG4105VFB Binds the 23S rRNA (By similarity) C0099_11375 ENOG4107QP8 phosphohexose isomerase C0099_11380 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) C0099_11395 ENOG4105CHU acetyl-coa acetyltransferase C0099_11435 ENOG4108ZUW Major pilin subunit C0099_11520 ENOG4108VPT UPF0234 protein C0099_11525 ENOG4105NBK UPF0345 protein C0099_11535 ENOG4105CDH Citrulline--aspartate ligase C0099_11540 ENOG4105DBV ornithine carbamoyltransferase C0099_11545 ENOG4105C8Y Acetylornithine aminotransferase C0099_11550 ENOG41082GY Binds directly to 16S ribosomal RNA (By similarity) C0099_11555 ENOG4105CJR Integral membrane protein (MviN C0099_11575 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C0099_11585 ENOG4105BZU Histidine kinase C0099_11595 ENOG4105CPF Cell wall formation (By similarity) C0099_11615 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase C0099_11620 ENOG4107SJB teichoic acid biosynthesis C0099_11645 ENOG4105DTS flagellar hook-associated C0099_11650 ENOG4105MQ3 flagellar protein FliS C0099_11655 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) C0099_11665 ENOG4105VM1 flagellar C0099_11670 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) C0099_11675 ENOG4105VQ0 flagellar hook-basal body complex protein fliE C0099_11685 ENOG4105BZU Histidine kinase C0099_11690 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) C0099_11695 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C0099_11705 ENOG4108JIR Flagellum-specific ATP synthase C0099_11725 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C0099_11730 ENOG4105DD5 Flagellar motor switch protein C0099_11735 ENOG4105K0P flagellar biosynthesis protein C0099_11740 ENOG4105CN7 Flagellar biosynthetic protein FliP C0099_11745 ENOG4105VS8 Flagellar biosynthetic protein fliq C0099_11750 ENOG4105D19 Role in flagellar biosynthesis (By similarity) C0099_11760 ENOG4105DTJ flagellar hook-associated protein C0099_11765 ENOG4105E1Q flagellar hook-associated protein C0099_11770 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj C0099_11775 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) C0099_11780 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) C0099_11785 ENOG4105CGA flagellar basal-body rod protein FlgG C0099_11790 ENOG4108KPB Flagellar basal-body rod protein FlgF C0099_11795 ENOG4105BZE flagellar hook protein, FlgE C0099_11800 ENOG4105W00 Flagellar hook capping protein C0099_11805 ENOG4108ZC9 flagellar basal-body rod protein flgc C0099_11810 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C0099_11830 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C0099_11840 ENOG4105VDM plasmid maintenance system antidote protein, xre family C0099_11845 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C0099_11855 ENOG4105ER2 Ompa motb domain protein C0099_11860 ENOG4105E14 MotA TolQ exbB proton channel C0099_11865 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C0099_11875 ENOG4105FZW flagellar biosynthesis regulator FlhF C0099_11880 ENOG4105D7B Flagellar biosynthesis protein flha C0099_11885 ENOG4105D00 flagellar biosynthetic protein flhB C0099_11895 ENOG4108R99 pseudouridine synthase C0099_11910 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C0099_11915 ENOG4105EZE Cupin 4 family protein C0099_11920 ENOG4105GJM (LipO)protein C0099_11925 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C0099_11935 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C0099_11945 ENOG4105F8C transglutaminase domain-containing protein C0099_11950 ENOG4105CVE Lytic murein transglycosylase C0099_11955 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C0099_11960 ENOG4108K5P (LipO)protein C0099_11965 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) C0099_11970 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) C0099_11975 ENOG4108Z9W Outer membrane porin C0099_11980 ENOG4105VEQ Cold shock protein C0099_11985 ENOG4105ETU transcriptional activator (TenA C0099_11995 ENOG4105EAH synthase C0099_12005 ENOG4105CPC Aldo Keto reductase C0099_12010 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) C0099_12015 ENOG4105C1J atp-dependent rna helicase C0099_12030 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) C0099_12035 ENOG4105W8H transhydrogenase (subunit alpha C0099_12040 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) C0099_12045 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C0099_12050 ENOG4105EU8 FAD linked oxidase domain protein C0099_12055 ENOG4105CQB FAD linked oxidase domain protein C0099_12060 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) C0099_12075 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C0099_12095 ENOG4105FDP GntR family transcriptional regulator C0099_12105 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C0099_12110 ENOG4105K46 50S ribosomal protein l27 C0099_12115 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C0099_12120 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C0099_12125 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C0099_12135 ENOG4105KHC sulfurtransferase C0099_12140 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C0099_12145 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) C0099_12150 ENOG4105K8N protein family UPF0079, ATPase C0099_12155 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C0099_12160 ENOG4105DTN riboflavin biosynthesis protein ribF C0099_12165 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C0099_12170 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C0099_12175 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase C0099_12180 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) C0099_12190 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C0099_12200 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) C0099_12205 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) C0099_12220 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) C0099_12225 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving C0099_12240 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) C0099_12245 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C0099_12250 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C0099_12255 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) C0099_12260 ENOG4105CPF Cell wall formation (By similarity) C0099_12265 ENOG4105DFU Cell wall formation (By similarity) C0099_12270 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C0099_12275 ENOG4105CNI cell division protein FtsW C0099_12280 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C0099_12285 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C0099_12290 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) C0099_12295 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C0099_12300 ENOG4105CJN penicillin-binding protein C0099_12310 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) C0099_12315 ENOG4108V6E Cell division protein mraZ C0099_12330 ENOG4105EKE dihydroorotase C0099_12335 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C0099_12340 ENOG41082RQ UPF0102 protein C0099_12345 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) C0099_12355 ENOG4105DFU Cell wall formation (By similarity) C0099_12365 ENOG4107ZT5 Thiol disulfide interchange protein C0099_12370 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C0099_12375 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein C0099_12380 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C0099_12385 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C0099_12415 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) C0099_12425 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase C0099_12430 ENOG4105EQR Transposase IS116 IS110 IS902 C0099_12440 ENOG4105C72 UPF0176 protein C0099_12445 ENOG4105BZU Histidine kinase C0099_12465 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C0099_12470 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C0099_12480 ENOG4105KQC Competence protein C0099_12485 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C0099_12490 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) C0099_12500 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) C0099_12505 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) C0099_12510 ENOG4108KHX Diguanylate cyclase C0099_12515 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) C0099_12520 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) C0099_12525 ENOG4105XA0 heptosyltransferase ii C0099_12530 ENOG4105D16 lipopolysaccharide heptosyltransferase i C0099_12535 ENOG4107RJ7 Glycosyl transferase (Group 1 C0099_12540 ENOG4107543 (lipo)polysaccharide C0099_12560 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C0099_12570 ENOG4105BZ1 (ABC) transporter C0099_12575 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C0099_12635 ENOG4105BZU Histidine kinase C0099_12640 ENOG4105BZ1 (ABC) transporter C0099_12660 ENOG4105E2K Glycosyl transferase (Group 1 C0099_12680 ENOG4105JNK Glycosyl transferase (Group 1 C0099_12685 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) C0099_12700 ENOG4105F9F transposase C0099_12710 ENOG4105CPK Glycosyl transferase (Group 1 C0099_12715 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family C0099_12740 ENOG4105C30 Nad-dependent epimerase dehydratase C0099_12750 ENOG4105CPK Glycosyl transferase (Group 1 C0099_12755 ENOG4105D3Q Sugar transferase C0099_12780 ENOG4105CKK Glycosyl transferase, family 2 C0099_12825 ENOG4105CY0 Metallo-Beta-Lactamase C0099_12830 ENOG4105BZF Glycosyl transferase (Group 1 C0099_12855 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein C0099_12870 ENOG4105EY8 ABC transporter C0099_12880 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C0099_12895 ENOG4105GVR general secretion pathway protein D C0099_12935 ENOG4108VAU general secretion pathway protein G C0099_12940 ENOG4105D7Q type ii secretion system C0099_12945 ENOG4107QHF type ii secretion system protein e C0099_12955 ENOG4105CKK Glycosyl transferase, family 2 C0099_12985 ENOG4105ESV Glycosyl transferase, family 4 C0099_12995 ENOG4105C2M dna polymerase I C0099_13000 ENOG4108URH decarboxylase C0099_13010 ENOG4105CUV Homoserine Kinase C0099_13020 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C0099_13025 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) C0099_13030 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C0099_13035 ENOG4108Z03 MAF-like protein C0099_13040 ENOG4105C03 ribonuclease C0099_13055 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) C0099_13060 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C0099_13070 ENOG4105HF0 Membrane C0099_13075 ENOG4105BZU Histidine kinase C0099_13090 ENOG4107QN1 sodium solute C0099_13115 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) C0099_13125 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) C0099_13140 ENOG4108UQY Iron-storage protein C0099_13155 ENOG4105SG9 biopolymer transport protein, ExbD C0099_13160 ENOG4105DJY efflux transporter, rnd family, mfp subunit C0099_13165 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C0099_13170 ENOG4105ENJ RND efflux system, outer membrane lipoprotein C0099_13175 ENOG4105D05 Receptor C0099_13200 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C0099_13205 ENOG4105BZU Histidine kinase C0099_13235 ENOG4105PGM cation diffusion facilitator family transporter C0099_13250 ENOG4107R16 Multicopper oxidase C0099_13295 ENOG4105C59 p-type ATPase C0099_13330 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C0099_13350 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) C0099_13365 ENOG4105ETT transcriptional Regulator, LysR family C0099_13370 ENOG4105CCT upf0313 protein C0099_13375 ENOG4105BZU Histidine kinase C0099_13380 ENOG4105WH1 Two component transcriptional regulator luxr family C0099_13385 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C0099_13385 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor C0099_13390 ENOG4105BZU Histidine kinase C0099_13395 ENOG4105BZU Histidine kinase C0099_13405 ENOG4105C8Q Methyl-accepting chemotaxis C0099_13430 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C0099_13440 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) C0099_13450 ENOG4108ZYK Acyl carrier protein phosphodiesterase C0099_13455 ENOG4108R3E Dna-3-methyladenine glycosylase i C0099_13460 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C0099_13465 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) C0099_13650 ENOG4108QUU Morphogenesis Protein C0099_13655 ENOG4105QIB mu-like prophage Flumu protein gp29 C0099_13780 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) C0099_13795 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) C0099_13800 ENOG4108ZAI phosphatidylglycerophosphatase a C0099_13810 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) C0099_13815 ENOG4108004 Modulates RecA activity (By similarity) C0099_13820 ENOG4108IUZ ABC transporter C0099_13825 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C0099_13830 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA C0099_13835 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN C0099_13840 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) C0099_13845 ENOG4105C7B Threonine dehydratase C0099_13850 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C0099_13860 ENOG4107S9F NmrA family C0099_13865 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate C0099_13875 ENOG4105CYM Glutathione S-transferase C0099_13890 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) C0099_13910 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C0099_13915 ENOG4105CGK Exodeoxyribonuclease III C0099_13925 ENOG4108UGV hypoxanthine phosphoribosyltransferase C0099_13950 ENOG4105BZG amino acid carrier protein C0099_13965 ENOG4108M8H domain protein C0099_13980 ENOG4105D4A Cell wall formation (By similarity) C0099_13990 ENOG4108ISG Major Facilitator C0099_13995 ENOG4105C0Z ABC transporter C0099_14000 ENOG4108IV0 ABC, transporter C0099_14005 ENOG4105C32 Amino acid ABC transporter (Permease) C0099_14050 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C0099_14060 ENOG4105FYV Amp nucleosidase C0099_14065 ENOG4107ZXU DSBA oxidoreductase C0099_14095 ENOG4108JPW Aminotransferase C0099_14115 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) C0099_14120 ENOG4107GFK fumarate C0099_14125 ENOG4106DSS Tartrate dehydratase subunit alpha C0099_14130 ENOG4105EJC lysr family transcriptional regulator C0099_14150 ENOG4105P4J Allophanate hydrolase, subunit 1 C0099_14155 ENOG4107R7A Allophanate hydrolase subunit 2 C0099_14160 ENOG4105E7W lamb ycsf family protein C0099_14165 ENOG41061RM osmotically inducible lipoprotein C0099_14170 ENOG4105EHZ conserved protein UCP016719 C0099_14180 ENOG4108URH decarboxylase C0099_14185 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) C0099_14210 ENOG41080RH Thioredoxin C0099_14245 ENOG4107SK7 Sarcosine-dimethylglycine methyltransferase C0099_14265 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C0099_14270 ENOG4107T8T UPF0173 metal-dependent hydrolase C0099_14305 ENOG4105KT7 mgtC SapB transporter C0099_14315 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) C0099_14325 ENOG4108Z6B deaminase C0099_14355 ENOG4105F9F transposase C0099_14390 ENOG4105C3R Methionine synthase C0099_14400 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) C0099_14410 ENOG4105D5T phosphonate abc transporter C0099_14415 ENOG4105S7S phosphonate abc transporter C0099_14425 ENOG4105C2C drug resistance transporter, Bcr CflA C0099_14430 ENOG4105C0P Mg chelatase subunit ChlI C0099_14435 ENOG4108M3P Membrane C0099_14445 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C0099_14450 ENOG4108RA0 tripartite ATP-independent periplasmic transporter, DctQ component C0099_14455 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C0099_14460 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C0099_14465 ENOG4108W9H Tetr family transcriptional regulator C0099_14470 ENOG4105W0Z cytoplasmic protein C0099_14490 ENOG4105E0F Histidine kinase C0099_14495 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C0099_14505 ENOG4105ECA phosphoserine phosphatase homoserine phosphotransferase bifunctional protein C0099_14515 ENOG4105C5H ABC transporter C0099_14525 ENOG41081YB ApbE family C0099_14530 ENOG4105D7Z glutathione synthase C0099_14540 ENOG4107U4J modification C0099_14565 ENOG4105D0M Protease HtpX homolog C0099_14575 ENOG4108Z86 Glutamine amidotransferase C0099_14585 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) C0099_14590 ENOG4105GRZ Ycii-related protein C0099_14635 ENOG4107R16 Multicopper oxidase C0099_14640 ENOG4105DQ4 alcohol dehydrogenase C0099_14645 ENOG4105D94 Major Facilitator Superfamily C0099_14675 ENOG4108T5I Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C0099_14695 ENOG4105C5W Aldolase C0099_14700 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F C0099_14705 ENOG4105E39 Enoyl-CoA hydratase C0099_14710 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C0099_14720 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C0099_14725 ENOG4105C5R Aminotransferase C0099_14730 ENOG4107XBN GntR Family Transcriptional Regulator C0099_14740 ENOG4105CEY Amp-dependent synthetase and ligase C0099_14750 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C0099_14755 ENOG4105W39 Membrane C0099_14780 ENOG4108VJC ABC transporter, periplasmic molybdate-binding protein C0099_14785 ENOG4105MRD Phage derived protein Gp49-like (DUF891) C0099_14805 ENOG4105YES addiction module antidote protein C0099_14810 ENOG4105VUH addiction module killer protein C0099_14825 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C0099_14830 ENOG4108JB9 formate dehydrogenase C0099_14835 ENOG4107QIZ NADH dehydrogenase C0099_14845 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family C0099_14850 ENOG4105C01 Dihydroxy-acid dehydratase C0099_14855 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase C0099_14870 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) C0099_14875 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C0099_14880 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter C0099_14885 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C0099_14900 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) C0099_14905 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C0099_14925 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) C0099_14935 ENOG4108VYJ response regulator receiver protein C0099_14950 ENOG41061RM osmotically inducible lipoprotein C0099_14960 ENOG4106H29 UPF0391 membrane protein C0099_14965 ENOG4105K3G Periplasmic Protein C0099_14970 ENOG4108Z9W Outer membrane porin C0099_15000 ENOG4105C01 Dihydroxy-acid dehydratase C0099_15010 ENOG4105CG6 trap dicarboxylate transporter dctm subunit C0099_15020 ENOG4105CH5 extracellular solute-binding protein, family 7 C0099_15030 ENOG4108T2C cysteine dioxygenase type I C0099_15065 ENOG4105WSE Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity) C0099_15085 ENOG4105BZU Histidine kinase C0099_15095 ENOG4105EN6 Membrane C0099_15100 ENOG4105EKQ RNA-directed DNA polymerase C0099_15125 ENOG4105BZU Histidine kinase C0099_15130 ENOG4106855 Competence protein C0099_15180 ENOG4105C4R Atp-dependent dna helicase C0099_15185 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters C0099_15200 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C0099_15205 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) C0099_15210 ENOG4108Z43 UPF0250 protein C0099_15215 ENOG4105F0I Aminotransferase C0099_15220 ENOG4105DZ1 carboxypeptidase C0099_15230 ENOG4105CNI cell division protein FtsW C0099_15235 ENOG4105CJN penicillin-binding protein C0099_15250 ENOG4105DFF Rod shape-determining protein mreb C0099_15255 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C0099_15260 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C0099_15265 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C0099_15275 ENOG4105CUC YeeE YedE family protein C0099_15280 ENOG4105E7A Glutamine amidotransferase C0099_15295 ENOG4105BZU Histidine kinase C0099_15300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C0099_15310 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C0099_15330 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) C0099_15335 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) C0099_15340 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) C0099_15345 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) C0099_15350 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C0099_15355 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C0099_15360 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) C0099_15365 ENOG4107RAZ it plays a direct role in the translocation of protons across the membrane (By similarity) C0099_15380 ENOG4105FA0 parb-like partition protein C0099_15385 ENOG4107QJE Chromosome Partitioning Protein C0099_15390 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) C0099_15395 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C0099_15415 ENOG4105BZS acriflavin resistance protein C0099_15425 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) C0099_15440 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C0099_15450 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C0099_15455 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) C0099_15475 ENOG4105QAX Iron-sulfur C0099_15530 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b C0099_15540 ENOG4105BZU Histidine kinase C0099_15545 ENOG4105D0M Protease HtpX homolog C0099_15550 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C0099_15555 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C0099_15565 ENOG4105C79 DNA protecting protein DprA C0099_15570 ENOG4108RPN Protein smg homolog C0099_15575 ENOG4105C9U ATP-dependent DNA helicase RecQ C0099_15585 ENOG4105EKQ RNA-directed DNA polymerase C0099_15595 ENOG4105C5Q Transcriptional regulator C0099_15600 ENOG4105C0H protease C0099_15605 ENOG4105KA7 cytochrome C C0099_15615 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C0099_15640 ENOG4107R3N Filamentation induced by cAMP protein fic C0099_15645 ENOG4105DZR Type I site-specific deoxyribonuclease C0099_15665 ENOG4105CFP Peptidase U32 C0099_15675 ENOG4105C5H ABC transporter C0099_15680 ENOG4105YHU PTS system C0099_15690 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C0099_15695 ENOG4105DWV Homoserine O-trans-acetylase C0099_15700 ENOG4105DWV Homoserine O-trans-acetylase C0099_15710 ENOG4105BZU Histidine kinase C0099_15715 ENOG4105EYM Major Facilitator superfamily C0099_15725 ENOG41077A9 carbonic anhydrase C0099_15730 ENOG4105DKQ ROK family C0099_15735 ENOG4105BZU Histidine kinase C0099_15740 ENOG4105C25 Primosomal protein n' C0099_15745 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) C0099_15750 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) C0099_15755 ENOG4105C1A potassium transporter peripheral membrane C0099_15760 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C0099_15765 ENOG4105ES5 Histidine kinase C0099_15775 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C0099_15785 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C0099_15790 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C0099_15795 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) C0099_15800 ENOG4105X5M RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)