locus-tag	class	description
IWH25_00005	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IWH25_00010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IWH25_00025	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
IWH25_00030	COG0508	dehydrogenase complex catalyzes the overall conversion of
IWH25_00035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IWH25_00050	COG5002	protein histidine kinase activity
IWH25_00060	COG0545	Peptidyl-prolyl cis-trans isomerase
IWH25_00075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IWH25_00080	COG0501	Belongs to the peptidase M48B family
IWH25_00100	COG0840	transmembrane signaling receptor activity
IWH25_00105	COG0438	transferase activity, transferring glycosyl groups
IWH25_00110	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IWH25_00115	COG2326	polyphosphate kinase activity
IWH25_00130	COG0704	Plays a role in the regulation of phosphate uptake
IWH25_00135	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IWH25_00145	COG0573	inorganic phosphate transmembrane transporter activity
IWH25_00150	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IWH25_00155	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
IWH25_00170	COG0640	Transcriptional regulator
IWH25_00175	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
IWH25_00180	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IWH25_00180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IWH25_00190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IWH25_00200	COG0483	inositol monophosphate 1-phosphatase activity
IWH25_00210	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IWH25_00215	COG3954	Phosphoribulokinase
IWH25_00225	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IWH25_00230	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
IWH25_00235	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IWH25_00240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IWH25_00245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IWH25_00250	COG0126	phosphoglycerate kinase activity
IWH25_00265	COG2226	methyltransferase
IWH25_00285	COG0469	pyruvate kinase activity
IWH25_00290	COG5002	protein histidine kinase activity
IWH25_00290	COG3447	MASE1 domain protein
IWH25_00290	COG5001	Diguanylate cyclase
IWH25_00295	COG0778	Nitroreductase
IWH25_00310	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IWH25_00320	COG0339	signal peptide processing
IWH25_00345	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IWH25_00350	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IWH25_00355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IWH25_00360	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
IWH25_00375	COG0006	proline dipeptidase activity
IWH25_00380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IWH25_00410	COG0717	Belongs to the dCTP deaminase family
IWH25_00415	COG0489	protein tyrosine kinase activity
IWH25_00420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IWH25_00420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IWH25_00440	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IWH25_00455	COG3002	Belongs to the UPF0753 family
IWH25_00460	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IWH25_00465	COG1254	Belongs to the acylphosphatase family
IWH25_00470	COG0450	alkyl hydroperoxide reductase
IWH25_00485	COG3047	cAMP biosynthetic process
IWH25_00505	COG0745	RESPONSE REGULATOR receiver
IWH25_00510	COG0655	NAD(P)H dehydrogenase (quinone) activity
IWH25_00515	COG0583	DNA-binding transcription factor activity
IWH25_00545	COG0210	DNA helicase
IWH25_00560	COG0495	leucyl-tRNA aminoacylation
IWH25_00580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IWH25_00595	COG2358	TRAP transporter, solute receptor (TAXI family
IWH25_00610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IWH25_00615	COG4974	Belongs to the 'phage' integrase family
IWH25_00620	COG2205	protein histidine kinase activity
IWH25_00625	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IWH25_00630	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IWH25_00635	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IWH25_00640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IWH25_00645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IWH25_00700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IWH25_00705	COG0751	glycine-tRNA ligase activity
IWH25_00710	COG0752	glycyl-tRNA synthetase alpha subunit
IWH25_00720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IWH25_00725	COG4535	Mg2 and Co2 transporter CorC
IWH25_00730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IWH25_00735	COG1702	phosphate starvation-inducible protein PhoH
IWH25_00740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IWH25_00785	COG0625	glutathione transferase activity
IWH25_00840	COG0583	DNA-binding transcription factor activity
IWH25_00845	COG3384	dioxygenase
IWH25_00850	COG3038	cytochrome b561
IWH25_00860	COG2353	YceI-like domain
IWH25_00875	COG0242	peptide deformylase activity
IWH25_00910	COG1250	3-hydroxyacyl-CoA dehydrogenase
IWH25_00915	COG1012	belongs to the aldehyde dehydrogenase family
IWH25_00920	COG1024	Enoyl-CoA hydratase
IWH25_00925	COG2050	protein possibly involved in aromatic compounds catabolism
IWH25_00945	COG0840	transmembrane signaling receptor activity
IWH25_00965	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IWH25_00995	COG0583	DNA-binding transcription factor activity
IWH25_01000	COG1067	ATP-dependent peptidase activity
IWH25_01030	COG1959	2 iron, 2 sulfur cluster binding
IWH25_01035	COG3001	Fructosamine kinase
IWH25_01050	COG0004	ammonium transporteR
IWH25_01055	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
IWH25_01065	COG0352	thiamine-phosphate diphosphorylase activity
IWH25_01075	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
IWH25_01080	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
IWH25_01085	COG0237	dephospho-CoA kinase activity
IWH25_01095	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
IWH25_01100	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IWH25_01105	COG1233	COG1233 Phytoene dehydrogenase and related
IWH25_01110	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IWH25_01135	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IWH25_01150	COG3852	Histidine kinase
IWH25_01160	COG0174	glutamine synthetase
IWH25_01170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IWH25_01175	COG5001	Diguanylate cyclase
IWH25_01175	COG3300	MHYT domain
IWH25_01180	COG3568	Endonuclease Exonuclease Phosphatase
IWH25_01190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IWH25_01205	COG0012	GTP binding
IWH25_01210	COG0193	aminoacyl-tRNA hydrolase activity
IWH25_01215	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IWH25_01220	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IWH25_01230	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IWH25_01235	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
IWH25_01245	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IWH25_01255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IWH25_01260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IWH25_01265	COG0742	ribosomal rna small subunit methyltransferase
IWH25_01270	COG0612	Peptidase, M16
IWH25_01275	COG0612	Peptidase, M16
IWH25_01285	COG2884	Cell division ATP-binding protein ftsE
IWH25_01290	COG2177	Part of the ABC transporter FtsEX involved in
IWH25_01305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IWH25_01310	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
IWH25_01335	COG0109	protoheme IX farnesyltransferase activity
IWH25_01340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IWH25_01350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IWH25_01355	COG0511	ligase activity, forming carbon-carbon bonds
IWH25_01360	COG0439	Biotin carboxylase
IWH25_01365	COG2264	protein methyltransferase activity
IWH25_01375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IWH25_01395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IWH25_01405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IWH25_01410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IWH25_01420	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IWH25_01425	COG2089	acid synthase
IWH25_01430	COG1028	Short-chain dehydrogenase reductase Sdr
IWH25_01435	COG1083	cytidylyl-transferase
IWH25_01450	COG0107	imidazoleglycerol-phosphate synthase activity
IWH25_01460	COG0702	epimerase
IWH25_01500	COG1028	Short-chain dehydrogenase reductase Sdr
IWH25_01500	COG3347	Dehydrogenase
IWH25_01515	COG1028	Short-chain dehydrogenase reductase Sdr
IWH25_01520	COG1083	cytidylyl-transferase
IWH25_01530	COG2089	acid synthase
IWH25_01565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IWH25_01570	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
IWH25_01575	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
IWH25_01575	COG0662	Cupin 2, conserved barrel domain protein
IWH25_01595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IWH25_01620	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IWH25_01650	COG0210	DNA helicase
IWH25_01675	COG3245	cytochrome
IWH25_01695	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IWH25_01715	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
IWH25_01720	COG0583	DNA-binding transcription factor activity
IWH25_01745	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IWH25_01755	COG0791	NLP P60 protein
IWH25_01775	COG2030	dehydratase
IWH25_01780	COG1530	ribonuclease E activity
IWH25_01785	COG0826	peptidase U32
IWH25_01800	COG0424	maF-like protein
IWH25_01805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IWH25_01810	COG0799	negative regulation of ribosome biogenesis
IWH25_01815	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IWH25_01830	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IWH25_01845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IWH25_01845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IWH25_01855	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IWH25_01860	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IWH25_01865	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
IWH25_01880	COG1492	cobalamin metabolic process
IWH25_01885	COG0840	transmembrane signaling receptor activity
IWH25_01900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IWH25_01915	COG0583	DNA-binding transcription factor activity
IWH25_01920	COG0473	3-isopropylmalate dehydrogenase activity
IWH25_01935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IWH25_01960	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IWH25_01975	COG0243	molybdopterin cofactor binding
IWH25_01980	COG0437	4 iron, 4 sulfur cluster binding
IWH25_01990	COG3381	protein complex oligomerization
IWH25_02000	COG0798	PFAM Bile acid sodium symporter
IWH25_02005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IWH25_02030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IWH25_02070	COG0683	leucine binding
IWH25_02105	COG1797	cobyrinic acid a,c-diamide synthase activity
IWH25_02115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IWH25_02120	COG0508	dehydrogenase complex catalyzes the overall conversion of
IWH25_02125	COG0508	dehydrogenase complex catalyzes the overall conversion of
IWH25_02125	COG0022	dehydrogenase e1 component
IWH25_02130	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IWH25_02135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IWH25_02140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IWH25_02155	COG1429	ligase activity, forming nitrogen-metal bonds
IWH25_02170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IWH25_02175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IWH25_02180	COG4206	TonB-dependent receptor
IWH25_02200	COG0730	response to heat
IWH25_02205	COG1802	Transcriptional regulator
IWH25_02210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IWH25_02260	COG0730	response to heat
IWH25_02270	COG1024	Enoyl-CoA hydratase
IWH25_02275	COG1802	Transcriptional regulator
IWH25_02280	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IWH25_02280	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IWH25_02285	COG1703	isobutyryl-CoA mutase activity
IWH25_02290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IWH25_02295	COG4770	biotin carboxylase activity
IWH25_02310	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IWH25_02315	COG0129	dihydroxy-acid dehydratase activity
IWH25_02320	COG1331	Highly conserved protein containing a thioredoxin domain
IWH25_02330	COG0683	leucine binding
IWH25_02335	COG0559	Belongs to the binding-protein-dependent transport system permease family
IWH25_02355	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IWH25_02370	COG1981	membrane
IWH25_02400	COG0762	integral membrane protein
IWH25_02405	COG1872	DUF167
IWH25_02415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IWH25_02420	COG0540	Belongs to the ATCase OTCase family
IWH25_02430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IWH25_02435	COG1678	Uncharacterized ACR, COG1678
IWH25_02440	COG0415	Belongs to the DNA photolyase family
IWH25_02445	COG2198	Histidine kinase
IWH25_02445	COG0784	Response regulator, receiver
IWH25_02445	COG0643	Histidine kinase
IWH25_02445	COG0784	Response regulator, receiver
IWH25_02445	COG0643	Histidine kinase
IWH25_02445	COG2198	Histidine kinase
IWH25_02475	COG0351	phosphomethylpyrimidine kinase
IWH25_02480	COG0352	thiamine-phosphate diphosphorylase activity
IWH25_02485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IWH25_02490	COG2076	Multidrug Resistance protein
IWH25_02500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IWH25_02505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IWH25_02520	COG3150	esterase
IWH25_02535	COG3154	lipid carrier protein
IWH25_02540	COG0826	peptidase U32
IWH25_02545	COG0826	peptidase U32
IWH25_02555	COG1999	signal sequence binding
IWH25_02575	COG0018	arginyl-trna synthetase
IWH25_02580	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IWH25_02585	COG0537	adenosine 5'-monophosphoramidase activity
IWH25_02600	COG3842	ATPase activity
IWH25_02605	COG1176	ABC-type spermidine putrescine transport system, permease component I
IWH25_02610	COG1177	transmembrane transport
IWH25_02625	COG0045	succinate-CoA ligase (ADP-forming) activity
IWH25_02625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IWH25_02625	COG1042	CoA-binding domain protein
IWH25_02640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IWH25_02645	COG1012	belongs to the aldehyde dehydrogenase family
IWH25_02650	COG2766	serine protein kinase
IWH25_02655	COG2718	Belongs to the UPF0229 family
IWH25_02660	COG2719	SpoVR family
IWH25_02685	COG1131	(ABC) transporter
IWH25_02700	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IWH25_02705	COG1324	tolerance protein
IWH25_02710	COG4232	protein-disulfide reductase activity
IWH25_02720	COG5001	Diguanylate cyclase
IWH25_02735	COG0840	transmembrane signaling receptor activity
IWH25_02760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IWH25_02765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IWH25_02770	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IWH25_02775	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IWH25_02780	COG1546	Belongs to the CinA family
IWH25_02785	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IWH25_02790	COG2137	regulation of response to DNA damage stimulus
IWH25_02795	COG1137	ATPase activity
IWH25_02800	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IWH25_02805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IWH25_02815	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IWH25_02835	COG2815	serine threonine protein kinase
IWH25_02835	COG0515	serine threonine protein kinase
IWH25_02840	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IWH25_02845	COG0037	tRNA processing
IWH25_02880	COG0625	glutathione transferase activity
IWH25_02910	COG0617	tRNA 3'-terminal CCA addition
IWH25_02930	COG0741	lytic transglycosylase activity
IWH25_02935	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IWH25_02940	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IWH25_02955	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IWH25_02960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IWH25_03000	COG1238	metal cluster binding
IWH25_03025	COG2226	methyltransferase
IWH25_03035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IWH25_03040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IWH25_03045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IWH25_03050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IWH25_03055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IWH25_03060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IWH25_03080	COG1475	DNA binding
IWH25_03085	COG1192	Involved in chromosome partitioning
IWH25_03090	COG0357	Ribosomal RNA small subunit methyltransferase G
IWH25_03095	COG0445	tRNA wobble uridine modification
IWH25_03100	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IWH25_03115	COG2045	Belongs to the ComB family
IWH25_03120	COG3634	alkyl hydroperoxide reductase activity
IWH25_03135	COG0745	RESPONSE REGULATOR receiver
IWH25_03145	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IWH25_03150	COG0706	membrane insertase activity
IWH25_03160	COG0594	ribonuclease P activity
IWH25_03165	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IWH25_03170	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IWH25_03175	COG0592	DNA-directed DNA polymerase activity
IWH25_03190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IWH25_03195	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IWH25_03210	COG1187	pseudouridine synthase activity
IWH25_03220	COG0583	DNA-binding transcription factor activity
IWH25_03225	COG0783	Belongs to the Dps family
IWH25_03235	COG2922	Belongs to the Smg family
IWH25_03240	COG0758	DNA mediated transformation
IWH25_03250	COG0242	peptide deformylase activity
IWH25_03255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IWH25_03265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IWH25_03270	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IWH25_03280	COG5000	phosphorelay sensor kinase activity
IWH25_03285	COG2204	response regulator
IWH25_03290	COG0569	domain protein
IWH25_03305	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IWH25_03310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IWH25_03345	COG2271	Major facilitator Superfamily
IWH25_03350	COG2258	MOSC domain
IWH25_03355	COG1940	carbohydrate kinase activity
IWH25_03360	COG0288	reversible hydration of carbon dioxide
IWH25_03380	COG3852	Histidine kinase
IWH25_03395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IWH25_03405	COG3876	Protein conserved in bacteria
IWH25_03410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IWH25_03420	COG0515	serine threonine protein kinase
IWH25_03420	COG2815	serine threonine protein kinase
IWH25_03445	COG2814	Major facilitator Superfamily
IWH25_03450	COG0697	spore germination
IWH25_03525	COG4453	Protein conserved in bacteria
IWH25_03540	COG3422	double-strand break repair
IWH25_03565	COG2963	transposase activity
IWH25_03600	COG0004	ammonium transporteR
IWH25_03610	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IWH25_03620	COG0788	formyltetrahydrofolate deformylase activity
IWH25_03635	COG0488	(ABC) transporter
IWH25_03650	COG0488	(ABC) transporter
IWH25_03670	COG0189	ligase activity
IWH25_03685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IWH25_03690	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IWH25_03695	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IWH25_03700	COG2813	Specifically methylates the guanine in position
IWH25_03700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IWH25_03715	COG2814	Major facilitator Superfamily
IWH25_03740	COG4575	ribosome binding
IWH25_03745	COG0708	Exodeoxyribonuclease III
IWH25_03750	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IWH25_03760	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IWH25_03770	COG0154	amidase activity
IWH25_03775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IWH25_03780	COG1077	Cell shape determining protein MreB Mrl
IWH25_03785	COG1792	Involved in formation and maintenance of cell shape
IWH25_03795	COG0768	penicillin binding
IWH25_03800	COG0772	Belongs to the SEDS family
IWH25_03810	COG1686	Belongs to the peptidase S11 family
IWH25_03820	COG2921	Belongs to the UPF0250 family
IWH25_03825	COG0321	lipoyl(octanoyl) transferase activity
IWH25_03830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IWH25_03855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IWH25_03860	COG3338	carbonate dehydratase activity
IWH25_03865	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IWH25_03885	COG1968	undecaprenyl-diphosphatase activity
IWH25_03905	COG1881	PFAM PEBP family protein
IWH25_03910	COG3243	poly(R)-hydroxyalkanoic acid synthase
IWH25_03930	COG1960	acyl-CoA dehydrogenase activity
IWH25_03935	COG0288	reversible hydration of carbon dioxide
IWH25_03940	COG0183	Belongs to the thiolase family
IWH25_03945	COG0697	spore germination
IWH25_03950	COG1960	acyl-CoA dehydrogenase activity
IWH25_03970	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IWH25_03975	COG1024	Enoyl-CoA hydratase
IWH25_03980	COG4770	biotin carboxylase activity
IWH25_04000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IWH25_04020	COG3852	Histidine kinase
IWH25_04030	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IWH25_04045	COG1067	ATP-dependent peptidase activity
IWH25_04050	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
IWH25_04055	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
IWH25_04060	COG3639	organic phosphonate transmembrane transporter activity
IWH25_04080	COG1473	amidohydrolase
IWH25_04085	COG1660	Displays ATPase and GTPase activities
IWH25_04110	COG1194	a g-specific adenine glycosylase
IWH25_04115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IWH25_04125	COG0582	viral genome integration into host DNA
IWH25_04185	COG2003	Belongs to the UPF0758 family
IWH25_04325	COG2205	protein histidine kinase activity
IWH25_04410	COG1742	UPF0060 membrane protein
IWH25_04415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IWH25_04455	COG0475	glutathione-regulated potassium exporter activity
IWH25_04475	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IWH25_04490	COG0723	plastoquinol--plastocyanin reductase activity
IWH25_04510	COG3437	response regulator, receiver
IWH25_04510	COG2770	Histidine kinase
IWH25_04515	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
IWH25_04565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IWH25_04625	COG0583	DNA-binding transcription factor activity
IWH25_04630	COG0789	Transcriptional regulator
IWH25_04660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IWH25_04665	COG3088	subunit of a heme lyase
IWH25_04675	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IWH25_04750	COG0583	DNA-binding transcription factor activity
IWH25_04760	COG1253	flavin adenine dinucleotide binding
IWH25_04765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IWH25_04775	COG1404	Belongs to the peptidase S8 family
IWH25_04780	COG1960	acyl-CoA dehydrogenase activity
IWH25_04790	COG2022	thiamine diphosphate biosynthetic process
IWH25_04795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IWH25_04825	COG3276	selenocysteine insertion sequence binding
IWH25_04840	COG2864	formate dehydrogenase
IWH25_04845	COG0437	4 iron, 4 sulfur cluster binding
IWH25_04860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IWH25_04865	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IWH25_04875	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IWH25_04890	COG1561	YicC-like family, N-terminal region
IWH25_04895	COG0194	GDP metabolic process
IWH25_04900	COG1758	RNA polymerase activity
IWH25_04905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IWH25_04910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IWH25_04915	COG1024	Enoyl-CoA hydratase
IWH25_04920	COG0084	hydrolase, TatD family'
IWH25_04930	COG0243	molybdopterin cofactor binding
IWH25_04935	COG0437	4 iron, 4 sulfur cluster binding
IWH25_04940	COG0348	domain, Protein
IWH25_04970	COG3088	subunit of a heme lyase
IWH25_04975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IWH25_04985	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
IWH25_05000	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IWH25_05005	COG4133	protoheme IX ABC transporter activity
IWH25_05010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IWH25_05015	COG2146	nitrite reductase [NAD(P)H] activity
IWH25_05025	COG0375	protein maturation
IWH25_05035	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IWH25_05040	COG0298	carbon dioxide binding
IWH25_05045	COG0409	Hydrogenase expression formation protein
IWH25_05050	COG0309	Hydrogenase expression formation protein (HypE)
IWH25_05060	COG1024	Enoyl-CoA hydratase
IWH25_05060	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IWH25_05065	COG2204	response regulator
IWH25_05085	COG2198	Histidine kinase
IWH25_05085	COG5002	protein histidine kinase activity
IWH25_05085	COG0784	Response regulator, receiver
IWH25_05100	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
IWH25_05110	COG0280	phosphate acetyltransferase
IWH25_05110	COG0281	malic enzyme
IWH25_05120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IWH25_05135	COG0251	oxidation-reduction process
IWH25_05160	COG0583	DNA-binding transcription factor activity
IWH25_05170	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IWH25_05185	COG1028	Short-chain dehydrogenase reductase Sdr
IWH25_05200	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IWH25_05240	COG0318	PFAM AMP-dependent synthetase and ligase
IWH25_05260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IWH25_05275	COG4206	TonB-dependent receptor
IWH25_05290	COG0028	Belongs to the TPP enzyme family
IWH25_05305	COG2391	methyltransferase activity
IWH25_05310	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IWH25_05345	COG0602	queuosine metabolic process
IWH25_05355	COG2885	chlorophyll binding
IWH25_05360	COG0823	Involved in the tonB-independent uptake of proteins
IWH25_05380	COG0824	Thioesterase
IWH25_05390	COG4191	Histidine kinase
IWH25_05400	COG2255	four-way junction helicase activity
IWH25_05405	COG0628	permease
IWH25_05410	COG0632	four-way junction helicase activity
IWH25_05415	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IWH25_05430	COG0217	transcriptional regulatory protein
IWH25_05435	COG0433	COG0433 Predicted ATPase
IWH25_05440	COG2824	Alkylphosphonate utilization operon protein PhnA
IWH25_05445	COG0583	DNA-binding transcription factor activity
IWH25_05450	COG3193	protein, possibly involved in utilization of glycolate and propanediol
IWH25_05455	COG0583	DNA-binding transcription factor activity
IWH25_05460	COG0697	spore germination
IWH25_05465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IWH25_05480	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IWH25_05485	COG1950	PFAM Membrane protein of
IWH25_05490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IWH25_05505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IWH25_05510	COG1560	Kdo2-lipid A biosynthetic process
IWH25_05515	COG0438	transferase activity, transferring glycosyl groups
IWH25_05535	COG1132	(ABC) transporter
IWH25_05550	COG1216	Glycosyl transferase, family 2
IWH25_05570	COG0438	transferase activity, transferring glycosyl groups
IWH25_05575	COG2192	nodulation
IWH25_05580	COG1560	Kdo2-lipid A biosynthetic process
IWH25_05590	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IWH25_05600	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
IWH25_05615	COG0450	alkyl hydroperoxide reductase
IWH25_05620	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IWH25_05635	COG0523	cobalamin synthesis protein
IWH25_05640	COG0523	cobalamin synthesis protein
IWH25_05660	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IWH25_05675	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IWH25_05680	COG1418	mRNA catabolic process
IWH25_05690	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IWH25_05700	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IWH25_05705	COG0477	Major facilitator Superfamily
IWH25_05710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IWH25_05715	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
IWH25_05720	COG4191	Histidine kinase
IWH25_05740	COG1965	Belongs to the frataxin family
IWH25_05775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IWH25_05780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IWH25_05785	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IWH25_05790	COG0070	glutamate synthase
IWH25_05790	COG0069	glutamate synthase activity
IWH25_05790	COG0067	glutamate synthase
IWH25_05805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IWH25_05810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IWH25_05820	COG0302	gtp cyclohydrolase
IWH25_05825	COG1278	Cold shock
IWH25_05840	COG1703	isobutyryl-CoA mutase activity
IWH25_05840	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IWH25_05840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IWH25_05865	COG1022	Amp-dependent synthetase and ligase
IWH25_05875	COG0559	Belongs to the binding-protein-dependent transport system permease family
IWH25_05895	COG0318	PFAM AMP-dependent synthetase and ligase
IWH25_05905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IWH25_05920	COG2197	response regulator
IWH25_05935	COG2354	Protein conserved in bacteria
IWH25_05940	COG0277	FAD linked oxidase domain protein
IWH25_05960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IWH25_05970	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IWH25_05980	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IWH25_05985	COG0081	regulation of translation
IWH25_05990	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IWH25_05995	COG0222	ribosome binding
IWH25_06000	COG0085	RNA polymerase activity
IWH25_06005	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IWH25_06010	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IWH25_06015	COG0049	tRNA binding
IWH25_06020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IWH25_06025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IWH25_06030	COG0051	transcription antitermination factor activity, RNA binding
IWH25_06035	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IWH25_06040	COG0088	Forms part of the polypeptide exit tunnel
IWH25_06045	COG0089	rRNA binding
IWH25_06055	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IWH25_06060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IWH25_06065	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IWH25_06070	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IWH25_06075	COG0255	Belongs to the universal ribosomal protein uL29 family
IWH25_06080	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IWH25_06085	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IWH25_06090	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IWH25_06095	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IWH25_06100	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IWH25_06105	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IWH25_06110	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IWH25_06115	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IWH25_06120	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IWH25_06125	COG1841	ribosomal large subunit assembly
IWH25_06130	COG0200	Binds to the 23S rRNA
IWH25_06135	COG0201	protein transport
IWH25_06140	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IWH25_06145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IWH25_06150	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IWH25_06155	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IWH25_06160	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IWH25_06165	COG0202	RNA polymerase activity
IWH25_06170	COG0203	ribosomal protein L17
IWH25_06175	COG4191	Histidine kinase
IWH25_06180	COG0745	RESPONSE REGULATOR receiver
IWH25_06185	COG2202	Pas domain
IWH25_06185	COG2205	protein histidine kinase activity
IWH25_06190	COG5265	(ABC) transporter
IWH25_06200	COG1960	acyl-CoA dehydrogenase activity
IWH25_06205	COG0183	Belongs to the thiolase family
IWH25_06210	COG1307	EDD domain protein, DegV family
IWH25_06215	COG1024	Enoyl-CoA hydratase
IWH25_06215	COG1250	3-hydroxyacyl-CoA dehydrogenase
IWH25_06220	COG1607	acyl-coa hydrolase
IWH25_06230	COG1024	Enoyl-CoA hydratase
IWH25_06230	COG1250	3-hydroxyacyl-CoA dehydrogenase
IWH25_06235	COG0183	Belongs to the thiolase family
IWH25_06265	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IWH25_06270	COG0477	Major facilitator Superfamily
IWH25_06280	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
IWH25_06285	COG3852	Histidine kinase
IWH25_06290	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IWH25_06295	COG0454	-acetyltransferase
IWH25_06295	COG0456	acetyltransferase
IWH25_06305	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IWH25_06310	COG2027	D-alanyl-D-alanine carboxypeptidase
IWH25_06320	COG2151	metal-sulfur cluster biosynthetic enzyme
IWH25_06345	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IWH25_06365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IWH25_06375	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IWH25_06445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IWH25_06465	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
IWH25_06485	COG0477	Major facilitator Superfamily
IWH25_06490	COG1028	Short-chain dehydrogenase reductase Sdr
IWH25_06495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IWH25_06525	COG0633	Ferredoxin
IWH25_06555	COG4657	Part of a membrane complex involved in electron transport
IWH25_06560	COG2878	Part of a membrane complex involved in electron transport
IWH25_06565	COG4656	Part of a membrane complex involved in electron transport
IWH25_06585	COG2914	Belongs to the UPF0125 (RnfH) family
IWH25_06620	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IWH25_06640	COG4191	Histidine kinase
IWH25_06645	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IWH25_06650	COG0459	protein refolding
IWH25_06655	COG0745	RESPONSE REGULATOR receiver
IWH25_06665	COG3162	membrane
IWH25_06670	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IWH25_06680	COG0642	Histidine kinase
IWH25_06690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IWH25_06705	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
IWH25_06710	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
IWH25_06715	COG4208	sulfate ABC transporter
IWH25_06720	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IWH25_06725	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IWH25_06730	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IWH25_06745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
IWH25_06770	COG3876	Protein conserved in bacteria
IWH25_06780	COG2815	serine threonine protein kinase
IWH25_06780	COG0515	serine threonine protein kinase
IWH25_06785	COG0165	Argininosuccinate lyase
IWH25_06790	COG3275	phosphorelay sensor kinase activity
IWH25_06800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IWH25_06830	COG0181	hydroxymethylbilane synthase activity
IWH25_06840	COG2959	enzyme of heme biosynthesis
IWH25_06860	COG0408	coproporphyrinogen oxidase activity
IWH25_06865	COG0151	Belongs to the GarS family
IWH25_06875	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
IWH25_06895	COG0166	Belongs to the GPI family
IWH25_06900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IWH25_06910	COG0521	Mo-molybdopterin cofactor biosynthetic process
IWH25_06915	COG3028	Belongs to the UPF0307 family
IWH25_06920	COG0312	modulator of DNA gyrase
IWH25_06925	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IWH25_06930	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IWH25_06945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IWH25_06950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IWH25_06955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IWH25_06955	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IWH25_06960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IWH25_06970	COG0793	Belongs to the peptidase S41A family
IWH25_06975	COG4942	peptidase
IWH25_06985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IWH25_06995	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
IWH25_07005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IWH25_07010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IWH25_07015	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IWH25_07020	COG1459	type II secretion system
IWH25_07030	COG2165	general secretion pathway protein
IWH25_07035	COG2165	general secretion pathway protein
IWH25_07085	COG1450	Type ii and iii secretion system protein
IWH25_07090	COG3409	Peptidoglycan-binding domain 1 protein
IWH25_07090	COG3267	Type II secretory pathway component ExeA
IWH25_07105	COG1040	competence protein
IWH25_07110	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IWH25_07115	COG2226	methyltransferase
IWH25_07125	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IWH25_07130	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IWH25_07150	COG0517	IMP dehydrogenase activity
IWH25_07160	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IWH25_07180	COG1309	transcriptional regulator
IWH25_07190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IWH25_07200	COG0071	Belongs to the small heat shock protein (HSP20) family
IWH25_07205	COG1595	DNA-templated transcription, initiation
IWH25_07220	COG3220	belongs to the UPF0276 family
IWH25_07235	COG0494	nUDIX hydrolase
IWH25_07250	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IWH25_07265	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IWH25_07280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IWH25_07285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IWH25_07290	COG0741	lytic transglycosylase activity
IWH25_07295	COG0442	prolyl-tRNA aminoacylation
IWH25_07300	COG0494	nUDIX hydrolase
IWH25_07315	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
IWH25_07320	COG1765	OsmC-like protein
IWH25_07325	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IWH25_07330	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IWH25_07345	COG0316	Belongs to the HesB IscA family
IWH25_07350	COG0739	heme binding
IWH25_07355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IWH25_07385	COG0596	Alpha beta hydrolase
IWH25_07395	COG0598	Magnesium transport protein CorA
IWH25_07400	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IWH25_07420	COG1187	pseudouridine synthase activity
IWH25_07450	COG1136	(ABC) transporter
IWH25_07450	COG0577	efflux transmembrane transporter activity
IWH25_07455	COG0577	efflux transmembrane transporter activity
IWH25_07455	COG1136	(ABC) transporter
IWH25_07460	COG0577	efflux transmembrane transporter activity
IWH25_07460	COG1136	(ABC) transporter
IWH25_07470	COG0284	orotidine-5'-phosphate decarboxylase activity
IWH25_07485	COG5001	Diguanylate cyclase
IWH25_07485	COG5002	protein histidine kinase activity
IWH25_07550	COG4953	penicillin-binding protein 1C
IWH25_07560	COG1690	Belongs to the RtcB family
IWH25_07585	COG0583	DNA-binding transcription factor activity
IWH25_07595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IWH25_07605	COG0784	Response regulator, receiver
IWH25_07605	COG3437	response regulator, receiver
IWH25_07610	COG4191	Histidine kinase
IWH25_07610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IWH25_07615	COG0501	Belongs to the peptidase M48B family
IWH25_07620	COG0583	DNA-binding transcription factor activity
IWH25_07630	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IWH25_07635	COG1643	Atp-dependent helicase
IWH25_07660	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
IWH25_07670	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
IWH25_07690	COG0142	geranyltranstransferase activity
IWH25_07725	COG0436	Aminotransferase
IWH25_07730	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IWH25_07740	COG0280	phosphate acetyltransferase
IWH25_07740	COG0281	malic enzyme
IWH25_07755	COG1414	Transcriptional regulator
IWH25_07760	COG0247	lactate metabolic process
IWH25_07775	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IWH25_07785	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IWH25_07800	COG1556	Lactate utilization protein
IWH25_07810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IWH25_07815	COG3447	MASE1 domain protein
IWH25_07815	COG5002	protein histidine kinase activity
IWH25_07815	COG5001	Diguanylate cyclase
IWH25_07825	COG1490	D-aminoacyl-tRNA deacylase activity
IWH25_07840	COG0475	glutathione-regulated potassium exporter activity
IWH25_07860	COG2084	Dehydrogenase
IWH25_07865	COG2084	Dehydrogenase
IWH25_07880	COG0235	Class ii aldolase
IWH25_07885	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IWH25_07890	COG0436	Aminotransferase
IWH25_07905	COG3437	response regulator, receiver
IWH25_07905	COG2205	protein histidine kinase activity
IWH25_07905	COG3850	Histidine kinase
IWH25_07905	COG4999	Histidine kinase
IWH25_07920	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IWH25_07930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IWH25_07935	COG0312	modulator of DNA gyrase
IWH25_07955	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IWH25_07970	COG2096	Adenosyltransferase
IWH25_07975	COG3622	Belongs to the hyi family
IWH25_07990	COG0277	FAD linked oxidase domain protein
IWH25_07995	COG0277	FAD linked oxidase domain protein
IWH25_08000	COG0247	lactate metabolic process
IWH25_08010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IWH25_08030	COG0513	Belongs to the DEAD box helicase family
IWH25_08040	COG0667	Aldo Keto reductase
IWH25_08060	COG0584	glycerophosphoryl diester phosphodiesterase
IWH25_08070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IWH25_08085	COG0564	pseudouridine synthase activity
IWH25_08095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IWH25_08120	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IWH25_08130	COG0429	hydrolase of the alpha beta-hydrolase fold
IWH25_08140	COG0859	PFAM glycosyl transferase family 9
IWH25_08165	COG0482	sulfurtransferase activity
IWH25_08190	COG0625	glutathione transferase activity
IWH25_08215	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IWH25_08220	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IWH25_08225	COG1862	Preprotein translocase
IWH25_08230	COG0343	queuine tRNA-ribosyltransferase activity
IWH25_08235	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IWH25_08245	COG1575	Belongs to the MenA family. Type 1 subfamily
IWH25_08250	COG1648	precorrin-2 dehydrogenase activity
IWH25_08250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IWH25_08255	COG2010	Cytochrome c
IWH25_08305	COG4263	nitrous-oxide reductase activity
IWH25_08310	COG2863	cytochrome
IWH25_08335	COG0348	domain, Protein
IWH25_08340	COG1122	ATPase activity
IWH25_08355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IWH25_08430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IWH25_08430	COG0189	ligase activity
IWH25_08435	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IWH25_08435	COG0189	ligase activity
IWH25_08445	COG1132	(ABC) transporter
IWH25_08460	COG0393	Putative heavy-metal-binding
IWH25_08465	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IWH25_08475	COG0535	radical SAM domain protein
IWH25_08500	COG3161	chorismate lyase activity
IWH25_08510	COG0651	ATP synthesis coupled electron transport
IWH25_08520	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IWH25_08525	COG0651	ATP synthesis coupled electron transport
IWH25_08530	COG1006	Multisubunit Na H antiporter MnhC subunit
IWH25_08560	COG4191	Histidine kinase
IWH25_08565	COG4566	intracellular signal transduction
IWH25_08575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IWH25_08585	COG1126	abc transporter atp-binding protein
IWH25_08595	COG2095	MarC family integral membrane protein
IWH25_08605	COG1522	sequence-specific DNA binding
IWH25_08610	COG2423	ornithine cyclodeaminase activity
IWH25_08630	COG1403	HNH endonuclease
IWH25_08655	COG1509	lysine 2,3-aminomutase activity
IWH25_08660	COG0604	alcohol dehydrogenase
IWH25_08670	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IWH25_08675	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IWH25_08680	COG1607	acyl-coa hydrolase
IWH25_08685	COG3246	L-lysine catabolic process to acetate
IWH25_08690	COG0384	phenazine biosynthesis protein PhzF
IWH25_08700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IWH25_08705	COG1570	exodeoxyribonuclease VII activity
IWH25_08740	COG0811	peptide transport
IWH25_08745	COG0848	biopolymer transport protein
IWH25_08750	COG1663	tetraacyldisaccharide 4'-kinase activity
IWH25_08755	COG2835	tetraacyldisaccharide 4'-kinase activity
IWH25_08760	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IWH25_08765	COG0563	adenylate kinase activity
IWH25_08770	COG0205	6-phosphofructokinase activity
IWH25_08775	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IWH25_08780	COG1881	PFAM PEBP family protein
IWH25_08790	COG0268	Binds directly to 16S ribosomal RNA
IWH25_08810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IWH25_08815	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IWH25_08820	COG0137	argininosuccinate synthase activity
IWH25_08830	COG3123	guanosine phosphorylase activity
IWH25_08835	COG1666	GTP binding
IWH25_08840	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IWH25_08850	COG0505	Belongs to the CarA family
IWH25_08870	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
IWH25_08875	COG0183	Belongs to the thiolase family
IWH25_08910	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IWH25_08915	COG1360	Flagellar Motor Protein
IWH25_08925	COG0745	RESPONSE REGULATOR receiver
IWH25_08930	COG2198	Histidine kinase
IWH25_08930	COG0643	Histidine kinase
IWH25_08935	COG0835	chemotaxis
IWH25_08940	COG0840	transmembrane signaling receptor activity
IWH25_08950	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IWH25_08955	COG2201	protein-glutamate methylesterase activity
IWH25_08970	COG0835	chemotaxis
IWH25_08970	COG0784	Response regulator, receiver
IWH25_08975	COG0835	chemotaxis
IWH25_08975	COG0784	Response regulator, receiver
IWH25_08985	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IWH25_08990	COG0784	Response regulator, receiver
IWH25_08990	COG0643	Histidine kinase
IWH25_08990	COG2198	Histidine kinase
IWH25_08995	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IWH25_09000	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IWH25_09020	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IWH25_09055	COG1558	bacterial-type flagellum-dependent cell motility
IWH25_09065	COG1749	Flagellar hook protein flgE
IWH25_09070	COG4787	bacterial-type flagellum-dependent cell motility
IWH25_09080	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
IWH25_09085	COG1706	bacterial-type flagellum-dependent cell motility
IWH25_09120	COG1338	Plays a role in the flagellum-specific transport system
IWH25_09125	COG3190	flagellar
IWH25_09130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IWH25_09135	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IWH25_09145	COG3144	bacterial-type flagellum assembly
IWH25_09155	COG1157	protein secretion by the type III secretion system
IWH25_09185	COG1677	Flagellar hook-basal body complex protein FliE
IWH25_09190	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
IWH25_09195	COG2257	FlhB HrpN YscU SpaS Family
IWH25_09225	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IWH25_09245	COG1216	Glycosyl transferase, family 2
IWH25_09245	COG0438	transferase activity, transferring glycosyl groups
IWH25_09270	COG0673	inositol 2-dehydrogenase activity
IWH25_09275	COG0318	PFAM AMP-dependent synthetase and ligase
IWH25_09310	COG3327	negative regulation of DNA-templated transcription, initiation
IWH25_09360	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IWH25_09365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IWH25_09370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IWH25_09375	COG0723	plastoquinol--plastocyanin reductase activity
IWH25_09380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IWH25_09385	COG2857	Cytochrome c1
IWH25_09390	COG0625	glutathione transferase activity
IWH25_09395	COG2969	positive regulation of protein catabolic process
IWH25_09400	COG0243	molybdopterin cofactor binding
IWH25_09405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IWH25_09410	COG4178	(ABC) transporter
IWH25_09415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IWH25_09425	COG2223	nitrite transmembrane transporter activity
IWH25_09430	COG2815	serine threonine protein kinase
IWH25_09430	COG0515	serine threonine protein kinase
IWH25_09455	COG5002	protein histidine kinase activity
IWH25_09460	COG3437	response regulator, receiver
IWH25_09470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IWH25_09475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IWH25_09480	COG1116	anion transmembrane transporter activity
IWH25_09500	COG0840	transmembrane signaling receptor activity
IWH25_09515	COG0247	lactate metabolic process
IWH25_09545	COG4628	conserved protein (DUF2132)
IWH25_09565	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IWH25_09570	COG1028	Short-chain dehydrogenase reductase Sdr
IWH25_09575	COG0583	DNA-binding transcription factor activity
IWH25_09585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IWH25_09600	COG0697	spore germination
IWH25_09605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IWH25_09625	COG1335	isochorismatase
IWH25_09645	COG1136	(ABC) transporter
IWH25_09675	COG0488	(ABC) transporter
IWH25_09690	COG2226	methyltransferase
IWH25_09705	COG1396	sequence-specific DNA binding
IWH25_09710	COG3135	benzoate transporter
IWH25_09715	COG1607	acyl-coa hydrolase
IWH25_09730	COG0235	Class ii aldolase
IWH25_09735	COG1309	transcriptional regulator
IWH25_09745	COG2084	Dehydrogenase
IWH25_09750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IWH25_09760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IWH25_09765	COG1028	Short-chain dehydrogenase reductase Sdr
IWH25_09770	COG3958	Transketolase
IWH25_09775	COG3959	Transketolase, thiamine diphosphate binding domain
IWH25_09780	COG0583	DNA-binding transcription factor activity
IWH25_09790	COG0583	DNA-binding transcription factor activity
IWH25_09810	COG0753	catalase activity
IWH25_09830	COG0564	pseudouridine synthase activity
IWH25_09845	COG1881	PFAM PEBP family protein
IWH25_09855	COG1028	Short-chain dehydrogenase reductase Sdr
IWH25_09905	COG2226	methyltransferase
IWH25_09910	COG2217	Heavy metal translocating P-type atpase
IWH25_09915	COG3437	response regulator, receiver
IWH25_09930	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IWH25_09935	COG2852	Protein conserved in bacteria
IWH25_09940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IWH25_09970	COG2205	protein histidine kinase activity
IWH25_09985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IWH25_09995	COG0402	S-adenosylhomocysteine deaminase activity
IWH25_10010	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IWH25_10020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IWH25_10025	COG0287	Prephenate dehydrogenase
IWH25_10030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IWH25_10040	COG0776	regulation of translation
IWH25_10050	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
IWH25_10055	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IWH25_10060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IWH25_10075	COG1678	Uncharacterized ACR, COG1678
IWH25_10085	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IWH25_10090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IWH25_10095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IWH25_10100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IWH25_10105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IWH25_10110	COG0072	phenylalanine-tRNA ligase activity
IWH25_10110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IWH25_10115	COG0776	regulation of translation
IWH25_10130	COG0778	Nitroreductase
IWH25_10135	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
IWH25_10160	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IWH25_10165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IWH25_10180	COG2951	lytic endotransglycosylase activity
IWH25_10195	COG0714	Associated with various cellular activities
IWH25_10205	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IWH25_10210	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
IWH25_10215	COG0321	lipoyl(octanoyl) transferase activity
IWH25_10215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IWH25_10230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IWH25_10245	COG0527	aspartate kinase activity
IWH25_10260	COG0720	synthase
IWH25_10285	COG0436	Aminotransferase
IWH25_10290	COG0436	Aminotransferase
IWH25_10325	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IWH25_10345	COG1335	isochorismatase
IWH25_10365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IWH25_10410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IWH25_10410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IWH25_10425	COG3706	GGDEF domain
IWH25_10430	COG0047	phosphoribosylformylglycinamidine synthase activity
IWH25_10430	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IWH25_10455	COG3132	Protein of unknown function, DUF480
IWH25_10465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IWH25_10475	COG2350	Protein conserved in bacteria
IWH25_10480	COG2917	probably involved in intracellular septation
IWH25_10500	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IWH25_10505	COG2226	methyltransferase
IWH25_10510	COG0596	Alpha beta hydrolase
IWH25_10515	COG0156	8-amino-7-oxononanoate synthase activity
IWH25_10530	COG3022	response to hydroperoxide
IWH25_10595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IWH25_10600	COG4106	trans-aconitate 2-methyltransferase activity
IWH25_10635	COG0625	glutathione transferase activity
IWH25_10655	COG1269	ATP hydrolysis coupled proton transport
IWH25_10675	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
IWH25_10680	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
IWH25_10740	COG0515	serine threonine protein kinase
IWH25_10785	COG0617	tRNA 3'-terminal CCA addition
IWH25_10785	COG0517	IMP dehydrogenase activity
IWH25_10785	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IWH25_10795	COG0688	phosphatidylethanolamine metabolic process
IWH25_10835	COG0386	Belongs to the glutathione peroxidase family
IWH25_10840	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IWH25_10860	COG0542	response to heat
IWH25_10885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IWH25_10890	COG4660	Part of a membrane complex involved in electron transport
IWH25_10910	COG2878	Part of a membrane complex involved in electron transport
IWH25_10915	COG4657	Part of a membrane complex involved in electron transport
IWH25_10920	COG0167	dihydroorotate dehydrogenase activity
IWH25_10930	COG0686	Belongs to the AlaDH PNT family
IWH25_10935	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IWH25_10940	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IWH25_10945	COG3842	ATPase activity
IWH25_10950	COG1178	ABC-type Fe3 transport system permease component
IWH25_10955	COG1840	ABC-type Fe3 transport system, periplasmic component
IWH25_10960	COG0791	NLP P60 protein
IWH25_10965	COG0604	alcohol dehydrogenase
IWH25_10995	COG2902	Dehydrogenase
IWH25_11005	COG1942	4-Oxalocrotonate Tautomerase
IWH25_11025	COG2188	Transcriptional regulator
IWH25_11050	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IWH25_11070	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IWH25_11075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IWH25_11080	COG0318	PFAM AMP-dependent synthetase and ligase
IWH25_11100	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IWH25_11105	COG1764	response to oxidative stress
IWH25_11110	COG1942	4-Oxalocrotonate Tautomerase
IWH25_11120	COG0583	DNA-binding transcription factor activity
IWH25_11160	COG0719	Fe-S assembly protein
IWH25_11165	COG0396	ATPase activity
IWH25_11170	COG0719	Fe-S assembly protein
IWH25_11180	COG0822	iron-sulfur transferase activity
IWH25_11185	COG2151	metal-sulfur cluster biosynthetic enzyme
IWH25_11200	COG1280	lysine exporter protein (LysE YggA)
IWH25_11215	COG1136	(ABC) transporter
IWH25_11230	COG5002	protein histidine kinase activity
IWH25_11230	COG2205	protein histidine kinase activity
IWH25_11230	COG0784	Response regulator, receiver
IWH25_11245	COG5002	protein histidine kinase activity
IWH25_11250	COG0745	RESPONSE REGULATOR receiver
IWH25_11255	COG5002	protein histidine kinase activity
IWH25_11255	COG2176	DNA-directed DNA polymerase activity
IWH25_11270	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IWH25_11315	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IWH25_11355	COG0251	oxidation-reduction process
IWH25_11370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IWH25_11375	COG0517	IMP dehydrogenase activity
IWH25_11375	COG0516	GMP reductase activity
IWH25_11380	COG2176	DNA-directed DNA polymerase activity
IWH25_11385	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IWH25_11395	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IWH25_11425	COG3300	MHYT domain
IWH25_11425	COG5001	Diguanylate cyclase
IWH25_11440	COG2204	response regulator
IWH25_11445	COG3852	Histidine kinase
IWH25_11460	COG2010	Cytochrome c
IWH25_11490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IWH25_11545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IWH25_11550	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IWH25_11595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IWH25_11600	COG3088	subunit of a heme lyase
IWH25_11615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IWH25_11625	COG4191	Histidine kinase
IWH25_11630	COG2204	response regulator
IWH25_11675	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
IWH25_11690	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IWH25_11715	COG0604	alcohol dehydrogenase
IWH25_11720	COG0477	Major facilitator Superfamily
IWH25_11725	COG0583	DNA-binding transcription factor activity
IWH25_11730	COG2827	Endonuclease containing a URI domain
IWH25_11770	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IWH25_11790	COG0840	transmembrane signaling receptor activity
IWH25_11805	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IWH25_11820	COG0824	Thioesterase
IWH25_11825	COG1454	alcohol dehydrogenase
IWH25_11835	COG1129	ABC transporter
IWH25_11855	COG0683	leucine binding
IWH25_11875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IWH25_11880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IWH25_11885	COG1944	ATP diphosphatase activity
IWH25_11895	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IWH25_11905	COG2204	response regulator
IWH25_11910	COG4191	Histidine kinase
IWH25_11915	COG2827	Endonuclease containing a URI domain
IWH25_11925	COG1136	(ABC) transporter
IWH25_11985	COG0697	spore germination
IWH25_11990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IWH25_11995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IWH25_12000	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IWH25_12005	COG0248	Ppx GppA phosphatase
IWH25_12010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IWH25_12015	COG1127	ABC transporter
IWH25_12030	COG1024	Enoyl-CoA hydratase
IWH25_12040	COG2832	Protein of unknown function (DUF454)
IWH25_12065	COG1960	acyl-CoA dehydrogenase activity
IWH25_12085	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IWH25_12095	COG0432	Pfam Uncharacterised protein family UPF0047
IWH25_12105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IWH25_12125	COG0587	DNA-directed DNA polymerase activity
IWH25_12145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IWH25_12160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IWH25_12165	COG1185	polyribonucleotide nucleotidyltransferase activity
IWH25_12170	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IWH25_12220	COG1538	Outer membrane efflux protein
IWH25_12235	COG0653	protein targeting
IWH25_12250	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
IWH25_12255	COG0745	RESPONSE REGULATOR receiver
IWH25_12265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IWH25_12275	COG2171	N-acyltransferase activity
IWH25_12295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IWH25_12315	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IWH25_12330	COG0483	inositol monophosphate 1-phosphatase activity
IWH25_12340	COG1045	serine acetyltransferase
IWH25_12350	COG1104	cysteine desulfurase activity
IWH25_12355	COG1104	cysteine desulfurase activity
IWH25_12360	COG0822	iron-sulfur transferase activity
IWH25_12370	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IWH25_12375	COG0443	Heat shock 70 kDa protein
IWH25_12420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IWH25_12425	COG0560	Phosphoserine phosphatase
IWH25_12435	COG5002	protein histidine kinase activity
IWH25_12435	COG2205	protein histidine kinase activity
IWH25_12435	COG0784	Response regulator, receiver
IWH25_12450	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IWH25_12475	COG1355	regulation of microtubule-based process
IWH25_12480	COG3174	membrane
IWH25_12485	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IWH25_12490	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IWH25_12510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IWH25_12515	COG2815	serine threonine protein kinase
IWH25_12515	COG0515	serine threonine protein kinase
IWH25_12525	COG0564	pseudouridine synthase activity
IWH25_12540	COG3243	poly(R)-hydroxyalkanoic acid synthase
IWH25_12545	COG1028	Short-chain dehydrogenase reductase Sdr
IWH25_12565	COG1902	pentaerythritol trinitrate reductase activity
IWH25_12570	COG1309	transcriptional regulator
IWH25_12585	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IWH25_12600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IWH25_12605	COG1752	Esterase of the alpha-beta hydrolase superfamily
IWH25_12610	COG0277	FAD linked oxidase domain protein
IWH25_12615	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IWH25_12620	COG1393	Belongs to the ArsC family
IWH25_12630	COG2183	response to ionizing radiation
IWH25_12645	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
IWH25_12685	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
IWH25_12690	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IWH25_12700	COG3321	synthase
IWH25_12700	COG0604	alcohol dehydrogenase
IWH25_12715	COG1278	Cold shock
IWH25_12735	COG3706	GGDEF domain
IWH25_12740	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IWH25_12745	COG1671	Belongs to the UPF0178 family
IWH25_12750	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IWH25_12755	COG5002	protein histidine kinase activity
IWH25_12755	COG2205	protein histidine kinase activity
IWH25_12755	COG0784	Response regulator, receiver
IWH25_12770	COG3437	response regulator, receiver
IWH25_12795	COG2900	Belongs to the SlyX family
IWH25_12800	COG0826	peptidase U32
IWH25_12810	COG0010	Belongs to the arginase family
IWH25_12855	COG0488	(ABC) transporter
IWH25_12875	COG1305	Transglutaminase-like
IWH25_12885	COG2308	Evidence 4 Homologs of previously reported genes of
IWH25_12895	COG0508	dehydrogenase complex catalyzes the overall conversion of
IWH25_12910	COG2205	protein histidine kinase activity
IWH25_12920	COG2204	response regulator
IWH25_12935	COG0583	DNA-binding transcription factor activity
IWH25_12970	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IWH25_12970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IWH25_12975	COG0509	glycine decarboxylation via glycine cleavage system
IWH25_12980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IWH25_12995	COG0613	PHP domain protein
IWH25_13000	COG0009	L-threonylcarbamoyladenylate synthase
IWH25_13005	COG1994	Peptidase M50
IWH25_13010	COG0180	Tryptophanyl-tRNA synthetase
IWH25_13020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IWH25_13025	COG1187	pseudouridine synthase activity
IWH25_13030	COG0779	Required for maturation of 30S ribosomal subunits
IWH25_13035	COG0195	Participates in both transcription termination and antitermination
IWH25_13035	COG2251	uridine kinase activity
IWH25_13040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IWH25_13045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IWH25_13050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IWH25_13060	COG3318	Belongs to the UPF0149 family
IWH25_13060	COG3012	SEC-C Motif Domain Protein
IWH25_13065	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IWH25_13075	COG3115	cell septum assembly
IWH25_13080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IWH25_13085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IWH25_13090	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IWH25_13105	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
IWH25_13110	COG0024	Methionine aminopeptidase
IWH25_13115	COG0052	Belongs to the universal ribosomal protein uS2 family
IWH25_13120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IWH25_13125	COG0528	UMP kinase activity
IWH25_13135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IWH25_13140	COG0575	Belongs to the CDS family
IWH25_13145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IWH25_13150	COG0750	zinc metalloprotease
IWH25_13165	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IWH25_13170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IWH25_13175	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IWH25_13180	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IWH25_13185	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IWH25_13190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IWH25_13200	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IWH25_13205	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IWH25_13210	COG0840	transmembrane signaling receptor activity
IWH25_13225	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IWH25_13235	COG4191	Histidine kinase
IWH25_13240	COG1139	Iron-sulfur cluster binding protein
IWH25_13250	COG0247	lactate metabolic process
IWH25_13255	COG2186	Transcriptional regulator
IWH25_13265	COG1028	Short-chain dehydrogenase reductase Sdr
IWH25_13285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IWH25_13315	COG1242	4 iron, 4 sulfur cluster binding
IWH25_13320	COG0443	Heat shock 70 kDa protein
IWH25_13330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IWH25_13335	COG1115	amino acid carrier protein
IWH25_13340	COG0251	oxidation-reduction process
IWH25_13345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IWH25_13360	COG3162	membrane
IWH25_13365	COG2030	dehydratase
IWH25_13370	COG0427	acetyl-CoA hydrolase
IWH25_13395	COG1024	Enoyl-CoA hydratase
IWH25_13400	COG1250	3-hydroxyacyl-CoA dehydrogenase
IWH25_13415	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IWH25_13420	COG2867	negative regulation of translational initiation
IWH25_13425	COG2914	Belongs to the UPF0125 (RnfH) family
IWH25_13440	COG0519	Catalyzes the synthesis of GMP from XMP
IWH25_13440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IWH25_13450	COG0659	secondary active sulfate transmembrane transporter activity
IWH25_13455	COG0513	Belongs to the DEAD box helicase family
IWH25_13470	COG2169	Transcriptional regulator
IWH25_13470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IWH25_13475	COG3447	MASE1 domain protein
IWH25_13475	COG5001	Diguanylate cyclase
IWH25_13475	COG5002	protein histidine kinase activity
IWH25_13500	COG0354	folic acid binding
IWH25_13505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IWH25_13510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IWH25_13525	COG0084	hydrolase, TatD family'
IWH25_13535	COG2176	DNA-directed DNA polymerase activity
IWH25_13545	COG0204	Acyl-transferase
IWH25_13580	COG0322	excinuclease ABC activity
IWH25_13590	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IWH25_13600	COG1472	Belongs to the glycosyl hydrolase 3 family
IWH25_13605	COG0736	holo-[acyl-carrier-protein] synthase activity
IWH25_13610	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IWH25_13615	COG1381	Involved in DNA repair and RecF pathway recombination
IWH25_13620	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IWH25_13625	COG0571	ribonuclease III activity
IWH25_13635	COG0681	Belongs to the peptidase S26 family
IWH25_13640	COG0481	GTPase activity
IWH25_13650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IWH25_13660	COG1595	DNA-templated transcription, initiation
IWH25_13665	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IWH25_13675	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IWH25_13680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IWH25_13695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IWH25_13700	COG0416	fatty acid biosynthetic process
IWH25_13705	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IWH25_13710	COG1399	metal-binding, possibly nucleic acid-binding protein
IWH25_13715	COG0424	maF-like protein
IWH25_13720	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IWH25_13725	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IWH25_13725	COG0616	signal peptide processing
IWH25_13740	COG0564	pseudouridine synthase activity
IWH25_13745	COG1530	ribonuclease E activity
IWH25_13750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IWH25_13755	COG0556	nucleotide-excision repair
IWH25_13775	COG0628	permease
IWH25_13780	COG2032	superoxide dismutase activity
IWH25_13785	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IWH25_13805	COG3706	GGDEF domain
IWH25_13810	COG1217	gtp-binding protein TYPA
IWH25_13830	COG1032	radical SAM domain protein
IWH25_13835	COG0745	RESPONSE REGULATOR receiver
IWH25_13845	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
IWH25_13855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IWH25_13855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IWH25_13860	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IWH25_13865	COG0583	DNA-binding transcription factor activity
IWH25_13870	COG0477	Major facilitator Superfamily
IWH25_13885	COG0574	Belongs to the PEP-utilizing enzyme family
IWH25_13885	COG3848	Pyruvate phosphate dikinase
IWH25_13890	COG0517	IMP dehydrogenase activity
IWH25_13890	COG1125	glycine betaine transport
IWH25_13910	COG1012	belongs to the aldehyde dehydrogenase family
IWH25_13920	COG1522	sequence-specific DNA binding
IWH25_13925	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IWH25_13925	COG1199	ATP-dependent helicase activity
IWH25_13930	COG4948	Mandelate Racemase Muconate Lactonizing
IWH25_13935	COG0583	DNA-binding transcription factor activity
IWH25_13940	COG4628	conserved protein (DUF2132)
IWH25_13950	COG2199	diguanylate cyclase activity
IWH25_13965	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IWH25_13970	COG1704	LemA family
IWH25_13985	COG1573	uracil-dna glycosylase
IWH25_13990	COG0456	acetyltransferase
IWH25_14000	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IWH25_14030	COG2203	Gaf domain
IWH25_14030	COG4251	negative regulation of phosphorylation
IWH25_14030	COG5001	Diguanylate cyclase
IWH25_14030	COG3706	GGDEF domain
IWH25_14035	COG2201	protein-glutamate methylesterase activity
IWH25_14040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IWH25_14045	COG2226	methyltransferase
IWH25_14050	COG0328	RNA-DNA hybrid ribonuclease activity
IWH25_14065	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IWH25_14095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IWH25_14130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IWH25_14135	COG1388	LysM domain
IWH25_14135	COG0741	lytic transglycosylase activity
IWH25_14150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IWH25_14155	COG0601	transmembrane transport
IWH25_14185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IWH25_14200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IWH25_14205	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IWH25_14210	COG0740	serine-type endopeptidase activity
IWH25_14215	COG0544	peptidyl-prolyl cis-trans isomerase activity
IWH25_14225	COG2197	response regulator
IWH25_14235	COG1538	Outer membrane efflux protein
IWH25_14245	COG2200	EAL domain
IWH25_14255	COG2274	protein secretion by the type I secretion system
IWH25_14265	COG0544	peptidyl-prolyl cis-trans isomerase activity
IWH25_14315	COG4964	Belongs to the GSP D family
IWH25_14345	COG1562	ergosterol biosynthetic process
IWH25_14350	COG1562	ergosterol biosynthetic process
IWH25_14355	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IWH25_14370	COG4181	ATPase activity
IWH25_14380	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
IWH25_14395	COG1136	(ABC) transporter
IWH25_14400	COG0577	efflux transmembrane transporter activity
IWH25_14400	COG1136	(ABC) transporter
IWH25_14410	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IWH25_14415	COG0148	phosphopyruvate hydratase activity
IWH25_14420	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IWH25_14435	COG0504	CTP synthase activity
IWH25_14450	COG0045	succinate-CoA ligase (ADP-forming) activity
IWH25_14450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IWH25_14450	COG1042	CoA-binding domain protein
IWH25_14470	COG0542	response to heat
IWH25_14475	COG1028	Short-chain dehydrogenase reductase Sdr
IWH25_14485	COG3604	Transcriptional regulator
IWH25_14510	COG0840	transmembrane signaling receptor activity
IWH25_14520	COG0314	molybdopterin synthase activity
IWH25_14525	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IWH25_14530	COG0303	'Molybdopterin
IWH25_14535	COG1763	Mo-molybdopterin cofactor biosynthetic process
IWH25_14545	COG1199	ATP-dependent helicase activity
IWH25_14555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IWH25_14560	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IWH25_14565	COG0318	PFAM AMP-dependent synthetase and ligase
IWH25_14575	COG1305	Transglutaminase-like
IWH25_14590	COG0305	Participates in initiation and elongation during chromosome replication
IWH25_14600	COG3706	GGDEF domain
IWH25_14605	COG0359	binds to the 23S rRNA
IWH25_14610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IWH25_14620	COG0360	Binds together with S18 to 16S ribosomal RNA
IWH25_14655	COG0583	DNA-binding transcription factor activity
IWH25_14660	COG0730	response to heat
IWH25_14665	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IWH25_14675	COG0175	sulfate reduction
IWH25_14685	COG0114	fumarate hydratase activity
IWH25_14690	COG0175	sulfate reduction
IWH25_14695	COG2895	sulfate adenylyltransferase (ATP) activity
IWH25_14710	COG2974	May be involved in recombination
IWH25_14715	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IWH25_14720	COG0557	exoribonuclease II activity
IWH25_14730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IWH25_14735	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IWH25_14745	COG0330	HflC and HflK could
IWH25_14750	COG0330	HflC and HflK could
IWH25_14755	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IWH25_14760	COG1923	regulation of RNA biosynthetic process
IWH25_14765	COG1160	GTP binding
IWH25_14770	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IWH25_14775	COG2976	Protein conserved in bacteria
IWH25_14780	COG0124	histidyl-tRNA synthetase
IWH25_14785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IWH25_14800	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IWH25_14805	COG0105	UTP biosynthetic process
IWH25_14840	COG0037	tRNA processing
IWH25_14845	COG0825	malonyl-CoA metabolic process
IWH25_14850	COG3300	MHYT domain
IWH25_14850	COG5001	Diguanylate cyclase
IWH25_14855	COG5002	protein histidine kinase activity
IWH25_14870	COG0746	molybdenum cofactor guanylyltransferase activity
IWH25_14875	COG3852	Histidine kinase
IWH25_14885	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IWH25_14895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IWH25_14905	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IWH25_14910	COG0508	dehydrogenase complex catalyzes the overall conversion of
IWH25_14915	COG0567	Dehydrogenase, E1 component
IWH25_14925	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
IWH25_14930	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IWH25_14935	COG1053	succinate dehydrogenase
IWH25_14945	COG2009	succinate dehydrogenase
IWH25_14950	COG2188	Transcriptional regulator
IWH25_14955	COG0039	L-malate dehydrogenase activity
IWH25_14965	COG4191	Histidine kinase
IWH25_14970	COG3038	cytochrome b561
IWH25_14985	COG4772	TonB-dependent receptor
IWH25_15000	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
IWH25_15005	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IWH25_15045	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IWH25_15050	COG0564	pseudouridine synthase activity
IWH25_15055	COG3901	Regulator of nitric oxide reductase transcription
IWH25_15055	COG0348	domain, Protein
IWH25_15075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IWH25_15075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IWH25_15085	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IWH25_15090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IWH25_15115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IWH25_15125	COG0535	radical SAM domain protein
IWH25_15145	COG4772	TonB-dependent receptor
IWH25_15150	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
IWH25_15165	COG4654	Cytochrome c, class I
IWH25_15170	COG0840	transmembrane signaling receptor activity
IWH25_15180	COG3258	Cytochrome c
IWH25_15185	COG4566	intracellular signal transduction
IWH25_15225	COG3284	Transcriptional regulator
IWH25_15230	COG1012	belongs to the aldehyde dehydrogenase family
IWH25_15240	COG4654	Cytochrome c, class I
IWH25_15290	COG3284	Transcriptional regulator
IWH25_15300	COG1024	Enoyl-CoA hydratase
IWH25_15305	COG1028	Short-chain dehydrogenase reductase Sdr
IWH25_15320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IWH25_15325	COG1984	allophanate hydrolase subunit 2
IWH25_15330	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IWH25_15340	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IWH25_15355	COG4336	lyase activity
IWH25_15360	COG0583	DNA-binding transcription factor activity
IWH25_15365	COG0326	Molecular chaperone. Has ATPase activity
IWH25_15370	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IWH25_15375	COG0569	domain protein
IWH25_15380	COG0745	RESPONSE REGULATOR receiver
IWH25_15385	COG2205	protein histidine kinase activity
IWH25_15395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IWH25_15425	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IWH25_15430	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IWH25_15435	COG5557	Pfam Polysulphide reductase, NrfD
IWH25_15440	COG0437	4 iron, 4 sulfur cluster binding
IWH25_15445	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IWH25_15460	COG2267	carboxylic ester hydrolase activity
IWH25_15465	COG0306	phosphate transporter
IWH25_15480	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
IWH25_15485	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IWH25_15495	COG2201	protein-glutamate methylesterase activity
IWH25_15500	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IWH25_15505	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IWH25_15510	COG0835	chemotaxis
IWH25_15515	COG0840	transmembrane signaling receptor activity
IWH25_15520	COG0643	Histidine kinase
IWH25_15520	COG2198	Histidine kinase
IWH25_15530	COG0745	RESPONSE REGULATOR receiver
IWH25_15535	COG0840	transmembrane signaling receptor activity
IWH25_15540	COG4566	intracellular signal transduction
IWH25_15550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IWH25_15565	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IWH25_15570	COG1674	ftsk spoiiie
IWH25_15575	COG0492	ferredoxin-NADP+ reductase activity
IWH25_15615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IWH25_15650	COG4633	Protein conserved in bacteria
IWH25_15655	COG0672	)-iron permease
IWH25_15725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IWH25_15745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IWH25_15750	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
IWH25_15770	COG1429	ligase activity, forming nitrogen-metal bonds
IWH25_15795	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IWH25_15800	COG3204	pilus organization
IWH25_15805	COG0709	Synthesizes selenophosphate from selenide and ATP
IWH25_15820	COG2217	Heavy metal translocating P-type atpase
IWH25_15830	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IWH25_15835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IWH25_15875	COG3243	poly(R)-hydroxyalkanoic acid synthase
IWH25_15880	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
IWH25_15900	COG3259	Nickel-dependent hydrogenase
IWH25_15905	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
IWH25_15910	COG3383	formate dehydrogenase (NAD+) activity
IWH25_15915	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IWH25_15925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IWH25_15945	COG1007	ATP synthesis coupled electron transport
IWH25_15960	COG0713	ATP synthesis coupled electron transport
IWH25_15970	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IWH25_15975	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IWH25_15990	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
IWH25_15995	COG0649	NAD binding
IWH25_16000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IWH25_16005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IWH25_16010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IWH25_16025	COG0149	triose-phosphate isomerase activity
IWH25_16030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IWH25_16040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IWH25_16045	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IWH25_16060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IWH25_16065	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IWH25_16070	COG0505	Belongs to the CarA family
IWH25_16080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IWH25_16085	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IWH25_16090	COG0735	belongs to the Fur family
IWH25_16095	COG2119	membrane
IWH25_16100	COG0497	DNA recombination
IWH25_16105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IWH25_16110	COG1420	regulation of RNA biosynthetic process
IWH25_16115	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IWH25_16125	COG0840	transmembrane signaling receptor activity
IWH25_16130	COG0515	serine threonine protein kinase
IWH25_16130	COG2815	serine threonine protein kinase
IWH25_16135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IWH25_16140	COG0443	Heat shock 70 kDa protein
IWH25_16145	COG0484	heat shock protein binding
IWH25_16160	COG0215	cysteine-tRNA ligase activity
IWH25_16180	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IWH25_16185	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IWH25_16195	COG0861	Integral membrane protein TerC family
IWH25_16200	COG0514	ATP-dependent DNA helicase (RecQ)
IWH25_16210	COG1607	acyl-coa hydrolase
IWH25_16245	COG0861	Integral membrane protein TerC family
IWH25_16250	COG0642	Histidine kinase
IWH25_16265	COG3180	Ammonia monooxygenase
IWH25_16290	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
IWH25_16305	COG0861	Integral membrane protein TerC family
IWH25_16315	COG2084	Dehydrogenase
IWH25_16320	COG3193	protein, possibly involved in utilization of glycolate and propanediol
IWH25_16335	COG2828	Protein conserved in bacteria
IWH25_16355	COG3976	FMN-binding domain protein
IWH25_16355	COG1053	succinate dehydrogenase
IWH25_16360	COG0583	DNA-binding transcription factor activity
IWH25_16380	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
IWH25_16405	COG0583	DNA-binding transcription factor activity
IWH25_16410	COG4122	O-methyltransferase activity
IWH25_16430	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
IWH25_16445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IWH25_16460	COG2207	Transcriptional regulator
IWH25_16485	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IWH25_16495	COG0789	Transcriptional regulator
IWH25_16530	COG1301	dicarboxylic acid transport
IWH25_16545	COG2198	Histidine kinase
IWH25_16545	COG2205	protein histidine kinase activity
IWH25_16545	COG0784	Response regulator, receiver
IWH25_16590	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
IWH25_16595	COG1116	anion transmembrane transporter activity
IWH25_16600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IWH25_16605	COG1116	anion transmembrane transporter activity
IWH25_16605	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IWH25_16615	COG2197	response regulator
IWH25_16635	COG1172	Belongs to the binding-protein-dependent transport system permease family
IWH25_16650	COG2188	Transcriptional regulator
IWH25_16665	COG0765	amino acid transport
IWH25_16670	COG1126	abc transporter atp-binding protein
IWH25_16675	COG4266	Belongs to the allantoicase family
IWH25_16685	COG0829	nickel cation binding
IWH25_16690	COG0831	urea catabolic process
IWH25_16695	COG0832	Belongs to the urease beta subunit family
IWH25_16700	COG0804	urea catabolic process
IWH25_16705	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
IWH25_16710	COG0830	nickel cation binding
IWH25_16715	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
IWH25_16720	COG0513	Belongs to the DEAD box helicase family
IWH25_16730	COG0840	transmembrane signaling receptor activity
IWH25_16755	COG0285	dihydrofolate synthase activity
IWH25_16760	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IWH25_16765	COG0159	tryptophan synthase activity
IWH25_16770	COG0133	tryptophan synthase activity
IWH25_16775	COG0135	phosphoribosylanthranilate isomerase activity
IWH25_16780	COG0101	tRNA pseudouridine synthase activity
IWH25_16800	COG0473	3-isopropylmalate dehydrogenase activity
IWH25_16805	COG0066	3-isopropylmalate dehydratase activity
IWH25_16815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IWH25_16825	COG2814	Major facilitator Superfamily
IWH25_16835	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IWH25_16855	COG0440	acetolactate synthase activity
IWH25_16860	COG0028	Belongs to the TPP enzyme family
IWH25_16865	COG0318	PFAM AMP-dependent synthetase and ligase
IWH25_16875	COG1074	ATP-dependent DNA helicase activity
IWH25_16880	COG2887	Belongs to the helicase family. UvrD subfamily
IWH25_16885	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
IWH25_16890	COG0741	lytic transglycosylase activity
IWH25_16900	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IWH25_16905	COG0254	rRNA binding
IWH25_16915	COG2193	ferroxidase activity
IWH25_16920	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IWH25_16925	COG0501	Belongs to the peptidase M48B family
IWH25_16930	COG1162	GTPase activity
IWH25_16965	COG3278	Belongs to the heme-copper respiratory oxidase family
IWH25_17045	COG4969	Belongs to the N-Me-Phe pilin family
IWH25_17055	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IWH25_17060	COG1047	Peptidyl-prolyl cis-trans
IWH25_17065	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IWH25_17070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IWH25_17075	COG0196	riboflavin kinase activity
IWH25_17080	COG0860	N-Acetylmuramoyl-L-alanine amidase
IWH25_17085	COG0802	atpase or kinase
IWH25_17105	COG0446	pyridine nucleotide-disulphide oxidoreductase
IWH25_17105	COG1902	pentaerythritol trinitrate reductase activity
IWH25_17145	COG1722	exodeoxyribonuclease VII activity
IWH25_17150	COG0142	geranyltranstransferase activity
IWH25_17155	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IWH25_17160	COG1469	GTP cyclohydrolase I activity
IWH25_17165	COG0335	large ribosomal subunit rRNA binding
IWH25_17170	COG0336	Belongs to the RNA methyltransferase TrmD family
IWH25_17175	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IWH25_17180	COG0228	four-way junction DNA binding
IWH25_17190	COG1295	ribonuclease BN
IWH25_17200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IWH25_17205	COG1183	phosphatidylcholine synthase activity
IWH25_17210	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IWH25_17215	COG0440	acetolactate synthase activity
IWH25_17220	COG0028	Belongs to the TPP enzyme family
IWH25_17250	COG0795	lipopolysaccharide-transporting ATPase activity
IWH25_17255	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IWH25_17270	COG0525	valine-tRNA ligase activity
IWH25_17285	COG0425	Belongs to the sulfur carrier protein TusA family
IWH25_17290	COG4783	chaperone-mediated protein folding
IWH25_17295	COG0315	cyclic pyranopterin monophosphate synthase activity
IWH25_17310	COG1278	Cold shock
IWH25_17315	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IWH25_17320	COG0542	response to heat
IWH25_17325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IWH25_17330	COG0840	transmembrane signaling receptor activity
IWH25_17335	COG2224	Isocitrate lyase
IWH25_17345	COG0583	DNA-binding transcription factor activity
IWH25_17350	COG0730	response to heat
IWH25_17355	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IWH25_17380	COG0559	Belongs to the binding-protein-dependent transport system permease family
IWH25_17435	COG0501	Belongs to the peptidase M48B family
IWH25_17440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IWH25_17445	COG0538	isocitrate dehydrogenase activity
IWH25_17460	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
IWH25_17470	COG0446	pyridine nucleotide-disulphide oxidoreductase
IWH25_17485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IWH25_17490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IWH25_17495	COG1368	sulfuric ester hydrolase activity
IWH25_17505	COG2194	sulfuric ester hydrolase activity
IWH25_17525	COG1022	Amp-dependent synthetase and ligase
IWH25_17535	COG0300	oxidoreductase activity
IWH25_17550	COG0642	Histidine kinase
IWH25_17555	COG2194	sulfuric ester hydrolase activity
IWH25_17560	COG2003	Belongs to the UPF0758 family
IWH25_17565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IWH25_17575	COG0756	dUTP diphosphatase activity
IWH25_17580	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IWH25_17600	COG0745	RESPONSE REGULATOR receiver
IWH25_17605	COG2205	protein histidine kinase activity
IWH25_17620	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IWH25_17620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IWH25_17630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IWH25_17640	COG0586	Pfam SNARE associated Golgi protein
IWH25_17650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IWH25_17655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IWH25_17680	COG0840	transmembrane signaling receptor activity
IWH25_17690	COG1116	anion transmembrane transporter activity
IWH25_17695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IWH25_17715	COG2201	protein-glutamate methylesterase activity
IWH25_17720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IWH25_17725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IWH25_17730	COG4191	Histidine kinase
IWH25_17735	COG4566	intracellular signal transduction
IWH25_17745	COG0784	Response regulator, receiver
IWH25_17745	COG2198	Histidine kinase
IWH25_17745	COG2205	protein histidine kinase activity
IWH25_17760	COG3437	response regulator, receiver
IWH25_17760	COG0784	Response regulator, receiver
IWH25_17770	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IWH25_17775	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IWH25_17785	COG0617	tRNA 3'-terminal CCA addition
IWH25_17800	COG0840	transmembrane signaling receptor activity
IWH25_17805	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IWH25_17810	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IWH25_17815	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IWH25_17820	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IWH25_17830	COG2217	Heavy metal translocating P-type atpase
IWH25_17835	COG0789	Transcriptional regulator
IWH25_17855	COG1538	Outer membrane efflux protein
IWH25_17860	COG1999	signal sequence binding
IWH25_17880	COG1612	heme a metabolic process
IWH25_17895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IWH25_17920	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IWH25_17920	COG0543	2 iron, 2 sulfur cluster binding
IWH25_17925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IWH25_17930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IWH25_17945	COG0492	ferredoxin-NADP+ reductase activity
IWH25_17975	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IWH25_17985	COG1216	Glycosyl transferase, family 2
IWH25_17990	COG0297	glycogen (starch) synthase activity
IWH25_18000	COG0438	transferase activity, transferring glycosyl groups
IWH25_18010	COG4969	Belongs to the N-Me-Phe pilin family
IWH25_18020	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
IWH25_18040	COG1131	(ABC) transporter
IWH25_18065	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IWH25_18070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IWH25_18090	COG1716	ATPase activity
IWH25_18100	COG2815	serine threonine protein kinase
IWH25_18100	COG0515	serine threonine protein kinase
IWH25_18105	COG0861	Integral membrane protein TerC family
IWH25_18110	COG3338	carbonate dehydratase activity
IWH25_18130	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IWH25_18135	COG0045	succinate-CoA ligase (ADP-forming) activity
IWH25_18150	COG4191	Histidine kinase
IWH25_18155	COG1027	Aspartate ammonia-lyase
IWH25_18175	COG1126	abc transporter atp-binding protein
IWH25_18180	COG0765	amino acid transport
IWH25_18185	COG0765	amino acid transport
IWH25_18205	COG1794	racemase activity, acting on amino acids and derivatives
IWH25_18210	COG0583	DNA-binding transcription factor activity
IWH25_18230	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
IWH25_18245	COG1595	DNA-templated transcription, initiation
IWH25_18250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IWH25_18265	COG1858	cytochrome C peroxidase
IWH25_18285	COG0534	Mate efflux family protein
IWH25_18295	COG0501	Belongs to the peptidase M48B family
IWH25_18310	COG2201	protein-glutamate methylesterase activity
IWH25_18320	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IWH25_18330	COG0121	glutamine amidotransferase
IWH25_18335	COG0805	protein transport
IWH25_18340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IWH25_18345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IWH25_18355	COG0140	phosphoribosyl-ATP diphosphatase activity
IWH25_18360	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IWH25_18365	COG0107	imidazoleglycerol-phosphate synthase activity
IWH25_18370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IWH25_18375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IWH25_18380	COG0131	Imidazoleglycerol-phosphate dehydratase
IWH25_18385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IWH25_18410	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IWH25_18415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IWH25_18425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IWH25_18430	COG0271	Belongs to the BolA IbaG family
IWH25_18435	COG0842	Transport permease protein
IWH25_18440	COG1131	(ABC) transporter
IWH25_18455	COG2853	Lipoprotein
IWH25_18460	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IWH25_18465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IWH25_18470	COG1127	ABC transporter
IWH25_18475	COG1450	Type ii and iii secretion system protein
IWH25_18490	COG1459	type II secretion system
IWH25_18520	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IWH25_18525	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IWH25_18530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IWH25_18535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IWH25_18550	COG0134	indole-3-glycerol-phosphate synthase activity
IWH25_18555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IWH25_18570	COG0546	phosphoglycolate phosphatase activity
IWH25_18575	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IWH25_18580	COG2967	ApaG domain
IWH25_18585	COG2226	methyltransferase
IWH25_18590	COG0628	permease
IWH25_18595	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IWH25_18600	COG0653	protein targeting
IWH25_18605	COG0739	heme binding
IWH25_18620	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
IWH25_18625	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IWH25_18635	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IWH25_18640	COG1181	Belongs to the D-alanine--D-alanine ligase family
IWH25_18645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IWH25_18650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IWH25_18655	COG0772	Belongs to the SEDS family
IWH25_18660	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IWH25_18665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IWH25_18670	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IWH25_18685	COG3116	cell division
IWH25_18690	COG0275	rRNA processing
IWH25_18695	COG2001	Belongs to the MraZ family
IWH25_18720	COG0418	dihydroorotase activity
IWH25_18725	COG2205	protein histidine kinase activity
IWH25_18725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IWH25_18730	COG1396	sequence-specific DNA binding
IWH25_18735	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IWH25_18740	COG0792	nuclease activity
IWH25_18750	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IWH25_18760	COG0179	Fumarylacetoacetate (FAA) hydrolase
IWH25_18765	COG1942	4-Oxalocrotonate Tautomerase
IWH25_18775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IWH25_18785	COG0583	DNA-binding transcription factor activity
IWH25_18790	COG0386	Belongs to the glutathione peroxidase family
IWH25_18795	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IWH25_18805	COG3158	transport of potassium into the cell
IWH25_18835	COG1126	abc transporter atp-binding protein
IWH25_18840	COG0765	amino acid transport
IWH25_18845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IWH25_18850	COG0629	single-stranded DNA binding
IWH25_18855	COG2814	Major facilitator Superfamily
IWH25_18865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IWH25_18870	COG0308	aminopeptidase N
IWH25_18905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IWH25_18910	COG3852	Histidine kinase
IWH25_18915	COG1100	Small GTP-binding protein
IWH25_18920	COG4566	intracellular signal transduction
IWH25_18935	COG2154	pterin-4-alpha-carbinolamine dehydratase
IWH25_18940	COG0009	L-threonylcarbamoyladenylate synthase
IWH25_18945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)