locus-tag	class	description
D3093_00040	COG0114	fumarate hydratase activity
D3093_00060	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D3093_00075	COG0205	6-phosphofructokinase activity
D3093_00105	COG0288	reversible hydration of carbon dioxide
D3093_00120	COG0604	alcohol dehydrogenase
D3093_00120	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_00120	COG3321	synthase
D3093_00145	COG2960	long-chain fatty acid transporting porin activity
D3093_00165	COG0318	PFAM AMP-dependent synthetase and ligase
D3093_00175	COG0840	transmembrane signaling receptor activity
D3093_00195	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D3093_00200	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3093_00205	COG0343	queuine tRNA-ribosyltransferase activity
D3093_00210	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D3093_00215	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3093_00260	COG2897	thiosulfate sulfurtransferase activity
D3093_00280	COG3629	intracellular signal transduction
D3093_00280	COG3903	Transcriptional regulator
D3093_00360	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D3093_00365	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3093_00370	COG0242	peptide deformylase activity
D3093_00380	COG3070	regulator of competence-specific genes
D3093_00395	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D3093_00420	COG4120	Belongs to the binding-protein-dependent transport system permease family
D3093_00435	COG0489	protein tyrosine kinase activity
D3093_00440	COG0330	HflC and HflK could
D3093_00445	COG0330	HflC and HflK could
D3093_00470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D3093_00475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3093_00480	COG0028	Belongs to the TPP enzyme family
D3093_00495	COG0704	Plays a role in the regulation of phosphate uptake
D3093_00500	COG2862	Uncharacterized protein family, UPF0114
D3093_00520	COG0768	penicillin binding
D3093_00540	COG1744	ABC transporter substrate-binding protein PnrA-like
D3093_00545	COG3845	ABC transporter
D3093_00550	COG4603	Belongs to the binding-protein-dependent transport system permease family
D3093_00555	COG1079	Belongs to the binding-protein-dependent transport system permease family
D3093_00560	COG0295	cytidine deaminase activity
D3093_00565	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3093_00570	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D3093_00585	COG0697	spore germination
D3093_00620	COG0038	chloride channel
D3093_00630	COG2326	polyphosphate kinase activity
D3093_00635	COG0366	Alpha amylase catalytic
D3093_00645	COG2199	diguanylate cyclase activity
D3093_00645	COG2200	EAL domain
D3093_00645	COG2203	Gaf domain
D3093_00655	COG2135	peptidase activity
D3093_00665	COG0784	Response regulator, receiver
D3093_00670	COG2261	transglycosylase associated protein
D3093_00675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3093_00690	COG1733	regulation of RNA biosynthetic process
D3093_00705	COG2084	Dehydrogenase
D3093_00710	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_00725	COG0546	phosphoglycolate phosphatase activity
D3093_00740	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3093_00750	COG2832	Protein of unknown function (DUF454)
D3093_00755	COG1238	metal cluster binding
D3093_00760	COG3852	Histidine kinase
D3093_00765	COG0469	pyruvate kinase activity
D3093_00770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D3093_00785	COG0203	ribosomal protein L17
D3093_00790	COG1238	metal cluster binding
D3093_00805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D3093_00820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D3093_00825	COG0564	pseudouridine synthase activity
D3093_00830	COG1802	Transcriptional regulator
D3093_00835	COG3135	benzoate transporter
D3093_00840	COG0546	phosphoglycolate phosphatase activity
D3093_00860	COG0354	folic acid binding
D3093_00865	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3093_00870	COG3845	ABC transporter
D3093_00875	COG4603	Belongs to the binding-protein-dependent transport system permease family
D3093_00880	COG1079	Belongs to the binding-protein-dependent transport system permease family
D3093_00920	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3093_00935	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_00940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3093_00945	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D3093_00955	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D3093_00960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3093_00965	COG0351	phosphomethylpyrimidine kinase
D3093_00970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3093_00985	COG0670	Belongs to the BI1 family
D3093_01005	COG2030	dehydratase
D3093_01005	COG1012	belongs to the aldehyde dehydrogenase family
D3093_01010	COG0443	Heat shock 70 kDa protein
D3093_01035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3093_01035	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D3093_01090	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3093_01095	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3093_01105	COG0649	NAD binding
D3093_01110	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D3093_01120	COG1034	ATP synthesis coupled electron transport
D3093_01125	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D3093_01130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3093_01140	COG0713	ATP synthesis coupled electron transport
D3093_01155	COG1007	ATP synthesis coupled electron transport
D3093_01175	COG0346	lactoylglutathione lyase activity
D3093_01185	COG0519	Catalyzes the synthesis of GMP from XMP
D3093_01200	COG0442	prolyl-tRNA aminoacylation
D3093_01245	COG0052	Belongs to the universal ribosomal protein uS2 family
D3093_01250	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D3093_01255	COG0528	UMP kinase activity
D3093_01260	COG0233	cytoplasmic translational termination
D3093_01265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3093_01275	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D3093_01280	COG0750	zinc metalloprotease
D3093_01300	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3093_01305	COG3494	Protein of unknown function (DUF1009)
D3093_01310	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3093_01325	COG0583	DNA-binding transcription factor activity
D3093_01340	COG0372	Belongs to the citrate synthase family
D3093_01345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3093_01350	COG0658	competence protein
D3093_01350	COG2333	competence protein COMEC
D3093_01355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3093_01360	COG0303	'Molybdopterin
D3093_01365	COG0315	cyclic pyranopterin monophosphate synthase activity
D3093_01410	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3093_01420	COG0149	triose-phosphate isomerase activity
D3093_01450	COG0535	radical SAM domain protein
D3093_01455	COG0535	radical SAM domain protein
D3093_01460	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
D3093_01465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D3093_01475	COG0148	phosphopyruvate hydratase activity
D3093_01485	COG0037	tRNA processing
D3093_01505	COG0678	peroxiredoxin activity
D3093_01520	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3093_01540	COG0596	Alpha beta hydrolase
D3093_01545	COG0728	peptidoglycan biosynthetic process
D3093_01555	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3093_01590	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3093_01595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3093_01610	COG0745	RESPONSE REGULATOR receiver
D3093_01620	COG0745	RESPONSE REGULATOR receiver
D3093_01655	COG5002	protein histidine kinase activity
D3093_01655	COG5001	Diguanylate cyclase
D3093_01655	COG3447	MASE1 domain protein
D3093_01690	COG1024	Enoyl-CoA hydratase
D3093_01700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D3093_01705	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D3093_01710	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D3093_01715	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D3093_01720	COG2885	chlorophyll binding
D3093_01720	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3093_01725	COG3243	poly(R)-hydroxyalkanoic acid synthase
D3093_01740	COG2814	Major facilitator Superfamily
D3093_01745	COG0436	Aminotransferase
D3093_01755	COG1494	fructose-1,6-bisphosphatase
D3093_01760	COG0371	Dehydrogenase
D3093_01790	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D3093_01790	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D3093_01800	COG0656	L-ascorbic acid biosynthetic process
D3093_01815	COG0123	including yeast histone deacetylase and acetoin utilization protein
D3093_01825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3093_01830	COG0517	IMP dehydrogenase activity
D3093_01865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3093_01870	COG0045	succinate-CoA ligase (ADP-forming) activity
D3093_01890	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D3093_01905	COG2084	Dehydrogenase
D3093_01910	COG3622	Belongs to the hyi family
D3093_01915	COG3960	tartronate-semialdehyde synthase activity
D3093_01920	COG0352	thiamine-phosphate diphosphorylase activity
D3093_01920	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D3093_01925	COG1802	Transcriptional regulator
D3093_01930	COG0469	pyruvate kinase activity
D3093_01940	COG0574	Belongs to the PEP-utilizing enzyme family
D3093_01940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3093_01970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3093_01980	COG0693	protein deglycase activity
D3093_01985	COG2197	response regulator
D3093_01990	COG2197	response regulator
D3093_02005	COG0829	nickel cation binding
D3093_02010	COG0831	urea catabolic process
D3093_02015	COG0832	Belongs to the urease beta subunit family
D3093_02020	COG0804	urea catabolic process
D3093_02025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D3093_02030	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D3093_02035	COG0830	nickel cation binding
D3093_02040	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D3093_02045	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
D3093_02055	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3093_02070	COG0640	Transcriptional regulator
D3093_02100	COG1396	sequence-specific DNA binding
D3093_02160	COG0463	Glycosyl transferase, family 2
D3093_02180	COG1940	carbohydrate kinase activity
D3093_02230	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3093_02230	COG2885	chlorophyll binding
D3093_02235	COG2197	response regulator
D3093_02240	COG2205	protein histidine kinase activity
D3093_02240	COG2198	Histidine kinase
D3093_02240	COG0784	Response regulator, receiver
D3093_02255	COG0564	pseudouridine synthase activity
D3093_02265	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D3093_02265	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D3093_02310	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_02320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3093_02325	COG1763	Mo-molybdopterin cofactor biosynthetic process
D3093_02335	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D3093_02340	COG0314	molybdopterin synthase activity
D3093_02350	COG1280	lysine exporter protein (LysE YggA)
D3093_02385	COG4957	zinc ion binding
D3093_02425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3093_02430	COG0174	glutamine synthetase
D3093_02440	COG3842	ATPase activity
D3093_02445	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3093_02450	COG1177	transmembrane transport
D3093_02455	COG2957	Belongs to the agmatine deiminase family
D3093_02480	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D3093_02480	COG0321	lipoyl(octanoyl) transferase activity
D3093_02485	COG0084	hydrolase, TatD family'
D3093_02490	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3093_02495	COG0470	DNA polymerase III
D3093_02500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D3093_02505	COG1686	Belongs to the peptidase S11 family
D3093_02520	COG0840	transmembrane signaling receptor activity
D3093_02525	COG0525	valine-tRNA ligase activity
D3093_02535	COG1538	Outer membrane efflux protein
D3093_02545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3093_02565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3093_02570	COG0494	nUDIX hydrolase
D3093_02585	COG2897	thiosulfate sulfurtransferase activity
D3093_02605	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3093_02610	COG1126	abc transporter atp-binding protein
D3093_02615	COG0765	amino acid transport
D3093_02620	COG4597	amino acid ABC transporter
D3093_02625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3093_02630	COG0626	cystathionine gamma-synthase activity
D3093_02680	COG0123	including yeast histone deacetylase and acetoin utilization protein
D3093_02710	COG2358	TRAP transporter, solute receptor (TAXI family
D3093_02745	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D3093_02745	COG3608	succinylglutamate desuccinylase aspartoacylase
D3093_02750	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3093_02755	COG0512	Glutamine amidotransferase of anthranilate synthase
D3093_02760	COG0737	Belongs to the 5'-nucleotidase family
D3093_02770	COG0686	Belongs to the AlaDH PNT family
D3093_02785	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3093_02805	COG1846	Transcriptional regulator
D3093_02810	COG1024	Enoyl-CoA hydratase
D3093_02815	COG1597	lipid kinase activity
D3093_02820	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3093_02825	COG0113	porphobilinogen synthase activity
D3093_02830	COG1881	PFAM PEBP family protein
D3093_02840	COG2813	Specifically methylates the guanine in position
D3093_02845	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D3093_02850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3093_02855	COG0741	lytic transglycosylase activity
D3093_02865	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D3093_02870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3093_02885	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D3093_02890	COG0360	Binds together with S18 to 16S ribosomal RNA
D3093_02895	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D3093_02905	COG0359	binds to the 23S rRNA
D3093_02915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3093_02920	COG0305	Participates in initiation and elongation during chromosome replication
D3093_02925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3093_02930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3093_02935	COG1127	ABC transporter
D3093_02950	COG0024	Methionine aminopeptidase
D3093_02965	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D3093_02970	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_02975	COG1160	GTP binding
D3093_02995	COG2197	response regulator
D3093_03005	COG2197	response regulator
D3093_03025	COG5002	protein histidine kinase activity
D3093_03025	COG2205	protein histidine kinase activity
D3093_03025	COG0784	Response regulator, receiver
D3093_03035	COG0840	transmembrane signaling receptor activity
D3093_03070	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D3093_03075	COG2814	Major facilitator Superfamily
D3093_03090	COG0789	Transcriptional regulator
D3093_03095	COG0318	PFAM AMP-dependent synthetase and ligase
D3093_03115	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3093_03125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3093_03125	COG1116	anion transmembrane transporter activity
D3093_03140	COG0175	sulfate reduction
D3093_03145	COG0175	sulfate reduction
D3093_03150	COG1648	precorrin-2 dehydrogenase activity
D3093_03150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3093_03165	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3093_03180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3093_03180	COG4651	solute:proton antiporter activity
D3093_03200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3093_03205	COG0416	fatty acid biosynthetic process
D3093_03210	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D3093_03230	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D3093_03240	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D3093_03245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3093_03250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D3093_03255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3093_03255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3093_03265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3093_03265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3093_03270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D3093_03275	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3093_03280	COG0698	ribose 5-phosphate isomerase
D3093_03300	COG3685	Protein conserved in bacteria
D3093_03320	COG2153	protein acetylation
D3093_03330	COG1793	dna ligase
D3093_03340	COG2313	pseudouridylate synthase activity
D3093_03350	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3093_03370	COG1217	gtp-binding protein TYPA
D3093_03405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_03415	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_03425	COG1755	Isoprenylcysteine carboxyl methyltransferase
D3093_03430	COG3424	synthase
D3093_03440	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3093_03445	COG1492	cobalamin metabolic process
D3093_03505	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3093_03520	COG1024	Enoyl-CoA hydratase
D3093_03530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3093_03535	COG3411	Ferredoxin
D3093_03555	COG3546	catalase activity
D3093_03560	COG2814	Major facilitator Superfamily
D3093_03565	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D3093_03610	COG0546	phosphoglycolate phosphatase activity
D3093_03620	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3093_03650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3093_03660	COG0628	permease
D3093_03665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3093_03680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3093_03780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3093_03830	COG3108	Peptidase M15
D3093_03840	COG1773	rubredoxin
D3093_03855	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3093_03860	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D3093_03880	COG2205	protein histidine kinase activity
D3093_03910	COG2824	Alkylphosphonate utilization operon protein PhnA
D3093_03925	COG0243	molybdopterin cofactor binding
D3093_03930	COG2070	2-Nitropropane dioxygenase
D3093_03935	COG3706	GGDEF domain
D3093_03950	COG1410	methionine synthase
D3093_03950	COG0646	methionine synthase
D3093_03970	COG2853	Lipoprotein
D3093_03985	COG0488	(ABC) transporter
D3093_03990	COG1671	Belongs to the UPF0178 family
D3093_03995	COG2176	DNA-directed DNA polymerase activity
D3093_03995	COG5002	protein histidine kinase activity
D3093_04020	COG1640	4-alpha-glucanotransferase
D3093_04025	COG0745	RESPONSE REGULATOR receiver
D3093_04045	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3093_04050	COG0366	Alpha amylase catalytic
D3093_04065	COG1218	3'(2'),5'-bisphosphate nucleotidase
D3093_04070	COG2833	Protein of unknown function (DUF455)
D3093_04085	COG1960	acyl-CoA dehydrogenase activity
D3093_04090	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_04095	COG0318	PFAM AMP-dependent synthetase and ligase
D3093_04100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_04105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3093_04155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_04165	COG1846	Transcriptional regulator
D3093_04170	COG2267	carboxylic ester hydrolase activity
D3093_04185	COG2226	methyltransferase
D3093_04210	COG1201	RNA secondary structure unwinding
D3093_04220	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D3093_04225	COG0415	Belongs to the DNA photolyase family
D3093_04235	COG0735	belongs to the Fur family
D3093_04240	COG0523	cobalamin synthesis protein
D3093_04255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D3093_04260	COG1234	tRNA 3'-trailer cleavage
D3093_04270	COG0840	transmembrane signaling receptor activity
D3093_04275	COG0840	transmembrane signaling receptor activity
D3093_04290	COG4520	surface antigen
D3093_04320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3093_04320	COG4191	Histidine kinase
D3093_04335	COG0784	Response regulator, receiver
D3093_04335	COG3437	response regulator, receiver
D3093_04355	COG2076	Multidrug Resistance protein
D3093_04360	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_04365	COG1765	OsmC-like protein
D3093_04375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D3093_04385	COG0697	spore germination
D3093_04390	COG0367	asparagine synthase
D3093_04405	COG0438	transferase activity, transferring glycosyl groups
D3093_04410	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3093_04420	COG1086	Polysaccharide biosynthesis protein
D3093_04430	COG2885	chlorophyll binding
D3093_04445	COG0848	biopolymer transport protein
D3093_04455	COG0824	Thioesterase
D3093_04460	COG2255	four-way junction helicase activity
D3093_04475	COG0217	transcriptional regulatory protein
D3093_04480	COG1692	metallophosphoesterase
D3093_04485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D3093_04530	COG1830	Aldolase
D3093_04535	COG0352	thiamine-phosphate diphosphorylase activity
D3093_04540	COG0730	response to heat
D3093_04545	COG2067	long-chain fatty acid transport protein
D3093_04550	COG0604	alcohol dehydrogenase
D3093_04555	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D3093_04560	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D3093_04565	COG0483	inositol monophosphate 1-phosphatase activity
D3093_04585	COG2826	transposase and inactivated derivatives, IS30 family
D3093_04590	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3093_04595	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3093_04600	COG0509	glycine decarboxylation via glycine cleavage system
D3093_04605	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D3093_04620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D3093_04630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D3093_04635	COG0328	RNA-DNA hybrid ribonuclease activity
D3093_04640	COG0318	PFAM AMP-dependent synthetase and ligase
D3093_04645	COG0678	peroxiredoxin activity
D3093_04650	COG4232	protein-disulfide reductase activity
D3093_04655	COG1678	Uncharacterized ACR, COG1678
D3093_04665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3093_04670	COG0612	Peptidase, M16
D3093_04680	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3093_04685	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D3093_04690	COG3346	SURF1 family
D3093_04705	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D3093_04710	COG0109	protoheme IX farnesyltransferase activity
D3093_04715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3093_04720	COG1565	acr, cog1565
D3093_04720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3093_04730	COG0312	modulator of DNA gyrase
D3093_04740	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3093_04750	COG5487	UPF0391 membrane protein
D3093_04760	COG0741	lytic transglycosylase activity
D3093_04785	COG0564	pseudouridine synthase activity
D3093_04800	COG0515	serine threonine protein kinase
D3093_04800	COG3266	domain, Protein
D3093_04805	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3093_04810	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D3093_04820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3093_04835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3093_04840	COG1295	ribonuclease BN
D3093_04845	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3093_04855	COG3547	Transposase (IS116 IS110 IS902 family)
D3093_04865	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D3093_04875	COG0745	RESPONSE REGULATOR receiver
D3093_04885	COG0616	signal peptide processing
D3093_04900	COG0784	Response regulator, receiver
D3093_04900	COG2198	Histidine kinase
D3093_04900	COG5002	protein histidine kinase activity
D3093_04910	COG0390	transport system, permease component
D3093_04915	COG1116	anion transmembrane transporter activity
D3093_04925	COG0628	permease
D3093_04930	COG2205	protein histidine kinase activity
D3093_04950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3093_04955	COG0251	oxidation-reduction process
D3093_04965	COG0551	DNA topoisomerase type I activity
D3093_04965	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3093_04995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3093_05005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3093_05030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3093_05045	COG0505	Belongs to the CarA family
D3093_05055	COG1403	HNH endonuclease
D3093_05070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3093_05075	COG1393	Belongs to the ArsC family
D3093_05080	COG2890	protein-(glutamine-N5) methyltransferase activity
D3093_05085	COG0456	acetyltransferase
D3093_05085	COG1214	PFAM Peptidase M22, glycoprotease
D3093_05125	COG0538	isocitrate dehydrogenase activity
D3093_05135	COG3932	Exopolysaccharide synthesis, ExoD
D3093_05155	COG0473	3-isopropylmalate dehydrogenase activity
D3093_05185	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3093_05205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3093_05220	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3093_05240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3093_05245	COG1684	flagellar biosynthetic protein fliR
D3093_05250	COG1987	bacterial-type flagellum assembly
D3093_05255	COG1677	Flagellar hook-basal body complex protein FliE
D3093_05260	COG1558	bacterial-type flagellum-dependent cell motility
D3093_05265	COG1815	bacterial-type flagellum-dependent cell motility
D3093_05270	COG2257	FlhB HrpN YscU SpaS Family
D3093_05285	COG1338	Plays a role in the flagellum-specific transport system
D3093_05305	COG1360	Flagellar Motor Protein
D3093_05345	COG4786	Flagellar basal body rod
D3093_05350	COG4786	Flagellar basal body rod
D3093_05360	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D3093_05400	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3093_05425	COG0500	methyltransferase
D3093_05430	COG1132	(ABC) transporter
D3093_05435	COG0254	rRNA binding
D3093_05445	COG0071	Belongs to the small heat shock protein (HSP20) family
D3093_05465	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3093_05480	COG2186	Transcriptional regulator
D3093_05485	COG0563	adenylate kinase activity
D3093_05490	COG0201	protein transport
D3093_05495	COG0200	Binds to the 23S rRNA
D3093_05500	COG1841	ribosomal large subunit assembly
D3093_05515	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D3093_05520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D3093_05525	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D3093_05535	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D3093_05545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D3093_05550	COG0255	Belongs to the universal ribosomal protein uL29 family
D3093_05555	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D3093_05560	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D3093_05565	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D3093_05570	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D3093_05575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D3093_05580	COG0089	rRNA binding
D3093_05585	COG0088	Forms part of the polypeptide exit tunnel
D3093_05595	COG0051	transcription antitermination factor activity, RNA binding
D3093_05610	COG0049	tRNA binding
D3093_05625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D3093_05630	COG0085	RNA polymerase activity
D3093_05635	COG0222	ribosome binding
D3093_05640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D3093_05645	COG0081	regulation of translation
D3093_05650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D3093_05750	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D3093_05760	COG1940	carbohydrate kinase activity
D3093_05770	COG0840	transmembrane signaling receptor activity
D3093_05770	COG2972	Histidine kinase
D3093_05775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3093_05785	COG0411	ABC transporter
D3093_05815	COG0673	inositol 2-dehydrogenase activity
D3093_05825	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3093_05835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3093_05840	COG1309	transcriptional regulator
D3093_05850	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3093_05870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3093_05915	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3093_05920	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3093_05925	COG1530	ribonuclease E activity
D3093_05955	COG0436	Aminotransferase
D3093_05965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D3093_05980	COG2264	protein methyltransferase activity
D3093_05990	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D3093_06020	COG1597	lipid kinase activity
D3093_06030	COG0438	transferase activity, transferring glycosyl groups
D3093_06040	COG1519	Transferase
D3093_06045	COG1663	tetraacyldisaccharide 4'-kinase activity
D3093_06055	COG1280	lysine exporter protein (LysE YggA)
D3093_06085	COG3719	Belongs to the RNase T2 family
D3093_06090	COG0439	Biotin carboxylase
D3093_06095	COG0511	ligase activity, forming carbon-carbon bonds
D3093_06115	COG1230	cation diffusion facilitator family transporter
D3093_06130	COG0840	transmembrane signaling receptor activity
D3093_06145	COG3108	Peptidase M15
D3093_06150	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3093_06150	COG3409	Peptidoglycan-binding domain 1 protein
D3093_06180	COG2205	protein histidine kinase activity
D3093_06190	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3093_06220	COG1073	alpha beta
D3093_06225	COG1380	Effector of murein hydrolase LrgA
D3093_06230	COG1346	cytolysis
D3093_06235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3093_06240	COG0751	glycine-tRNA ligase activity
D3093_06270	COG0142	geranyltranstransferase activity
D3093_06295	COG4191	Histidine kinase
D3093_06295	COG0784	Response regulator, receiver
D3093_06310	COG2084	Dehydrogenase
D3093_06315	COG0277	FAD linked oxidase domain protein
D3093_06330	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D3093_06335	COG0488	(ABC) transporter
D3093_06365	COG2001	Belongs to the MraZ family
D3093_06385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3093_06395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3093_06410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D3093_06420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3093_06425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D3093_06430	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3093_06435	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D3093_06440	COG0849	cell division
D3093_06445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D3093_06460	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D3093_06485	COG0497	DNA recombination
D3093_06490	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3093_06505	COG0745	RESPONSE REGULATOR receiver
D3093_06510	COG0006	proline dipeptidase activity
D3093_06510	COG0006	proline dipeptidase activity
D3093_06520	COG2264	protein methyltransferase activity
D3093_06535	COG0210	DNA helicase
D3093_06540	COG2197	response regulator
D3093_06545	COG2197	response regulator
D3093_06575	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D3093_06585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3093_06595	COG2205	protein histidine kinase activity
D3093_06605	COG2202	Pas domain
D3093_06605	COG2205	protein histidine kinase activity
D3093_06645	COG2988	succinylglutamate desuccinylase activity
D3093_06650	COG3180	Ammonia monooxygenase
D3093_06665	COG0628	permease
D3093_06670	COG0330	HflC and HflK could
D3093_06690	COG0745	RESPONSE REGULATOR receiver
D3093_06710	COG1116	anion transmembrane transporter activity
D3093_06715	COG1643	Atp-dependent helicase
D3093_06730	COG2719	SpoVR family
D3093_06735	COG2718	Belongs to the UPF0229 family
D3093_06740	COG2766	serine protein kinase
D3093_06745	COG0745	RESPONSE REGULATOR receiver
D3093_06755	COG2205	protein histidine kinase activity
D3093_06755	COG0784	Response regulator, receiver
D3093_06760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3093_06775	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D3093_06815	COG1116	anion transmembrane transporter activity
D3093_06865	COG1131	(ABC) transporter
D3093_06880	COG0723	plastoquinol--plastocyanin reductase activity
D3093_06895	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3093_06905	COG0463	Glycosyl transferase, family 2
D3093_06935	COG0602	queuosine metabolic process
D3093_06940	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D3093_06980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D3093_07000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3093_07025	COG2010	Cytochrome c
D3093_07030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D3093_07040	COG0799	negative regulation of ribosome biogenesis
D3093_07045	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D3093_07050	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D3093_07060	COG0793	Belongs to the peptidase S41A family
D3093_07070	COG1051	belongs to the nudix hydrolase family
D3093_07090	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D3093_07100	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3093_07120	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3093_07130	COG4974	Belongs to the 'phage' integrase family
D3093_07135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3093_07145	COG0596	Alpha beta hydrolase
D3093_07165	COG4191	Histidine kinase
D3093_07175	COG4106	trans-aconitate 2-methyltransferase activity
D3093_07195	COG2226	methyltransferase
D3093_07200	COG0126	phosphoglycerate kinase activity
D3093_07210	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D3093_07225	COG3474	cytochrome
D3093_07230	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3093_07260	COG4166	transmembrane transport
D3093_07265	COG4166	transmembrane transport
D3093_07270	COG4174	ABC transporter (Permease)
D3093_07275	COG4239	(ABC) transporter, permease
D3093_07290	COG4172	Belongs to the ABC transporter superfamily
D3093_07300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3093_07310	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3093_07315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3093_07325	COG2358	TRAP transporter, solute receptor (TAXI family
D3093_07345	COG0587	DNA-directed DNA polymerase activity
D3093_07380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3093_07385	COG0625	glutathione transferase activity
D3093_07400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3093_07405	COG0601	transmembrane transport
D3093_07415	COG1024	Enoyl-CoA hydratase
D3093_07430	COG0583	DNA-binding transcription factor activity
D3093_07455	COG5001	Diguanylate cyclase
D3093_07460	COG0625	glutathione transferase activity
D3093_07465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3093_07475	COG0156	8-amino-7-oxononanoate synthase activity
D3093_07490	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_07505	COG1322	Protein conserved in bacteria
D3093_07510	COG1278	Cold shock
D3093_07520	COG0242	peptide deformylase activity
D3093_07525	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3093_07530	COG0101	tRNA pseudouridine synthase activity
D3093_07550	COG2378	regulation of single-species biofilm formation
D3093_07555	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3093_07570	COG0335	large ribosomal subunit rRNA binding
D3093_07580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D3093_07585	COG0228	four-way junction DNA binding
D3093_07590	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D3093_07630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3093_07645	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D3093_07660	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3093_07670	COG1131	(ABC) transporter
D3093_07680	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D3093_07685	COG0697	spore germination
D3093_07705	COG0489	protein tyrosine kinase activity
D3093_07705	COG3206	protein involved in exopolysaccharide biosynthesis
D3093_07715	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D3093_07725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3093_07740	COG0438	transferase activity, transferring glycosyl groups
D3093_07770	COG1215	transferase activity, transferring glycosyl groups
D3093_07780	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D3093_07790	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D3093_07795	COG0706	membrane insertase activity
D3093_07800	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D3093_07815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3093_07825	COG0598	Magnesium transport protein CorA
D3093_07840	COG0825	malonyl-CoA metabolic process
D3093_07855	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3093_07860	COG4974	Belongs to the 'phage' integrase family
D3093_07880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D3093_07885	COG0517	IMP dehydrogenase activity
D3093_07900	COG0271	Belongs to the BolA IbaG family
D3093_07930	COG1840	ABC-type Fe3 transport system, periplasmic component
D3093_07935	COG1741	Belongs to the pirin family
D3093_07940	COG1178	ABC-type Fe3 transport system permease component
D3093_07945	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3093_07955	COG0135	phosphoribosylanthranilate isomerase activity
D3093_07975	COG2423	ornithine cyclodeaminase activity
D3093_07985	COG0776	regulation of translation
D3093_07995	COG0539	negative regulation of cytoplasmic translation
D3093_08010	COG0405	Gamma-glutamyltransferase
D3093_08030	COG1741	Belongs to the pirin family
D3093_08035	COG0303	'Molybdopterin
D3093_08050	COG2205	protein histidine kinase activity
D3093_08050	COG5002	protein histidine kinase activity
D3093_08050	COG0784	Response regulator, receiver
D3093_08060	COG0463	Glycosyl transferase, family 2
D3093_08070	COG0071	Belongs to the small heat shock protein (HSP20) family
D3093_08095	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D3093_08095	COG2755	lipolytic protein G-D-S-L family
D3093_08100	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D3093_08130	COG1215	transferase activity, transferring glycosyl groups
D3093_08150	COG1012	belongs to the aldehyde dehydrogenase family
D3093_08185	COG3162	membrane
D3093_08200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3093_08205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3093_08210	COG1040	competence protein
D3093_08215	COG1987	bacterial-type flagellum assembly
D3093_08220	COG4106	trans-aconitate 2-methyltransferase activity
D3093_08240	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D3093_08245	COG0513	Belongs to the DEAD box helicase family
D3093_08250	COG1970	mechanosensitive ion channel activity
D3093_08255	COG0653	protein targeting
D3093_08260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3093_08265	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D3093_08275	COG0494	nUDIX hydrolase
D3093_08280	COG0514	ATP-dependent DNA helicase (RecQ)
D3093_08305	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3093_08305	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3093_08315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3093_08345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3093_08360	COG0412	Dienelactone hydrolase
D3093_08365	COG0033	Phosphoglucomutase
D3093_08370	COG1278	Cold shock
D3093_08400	COG0302	gtp cyclohydrolase
D3093_08405	COG2202	Pas domain
D3093_08405	COG2205	protein histidine kinase activity
D3093_08420	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_08435	COG0285	dihydrofolate synthase activity
D3093_08440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3093_08450	COG0133	tryptophan synthase activity
D3093_08455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3093_08460	COG2205	protein histidine kinase activity
D3093_08460	COG5002	protein histidine kinase activity
D3093_08460	COG0784	Response regulator, receiver
D3093_08465	COG2205	protein histidine kinase activity
D3093_08470	COG1252	NADH dehydrogenase
D3093_08505	COG0802	atpase or kinase
D3093_08515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D3093_08520	COG2887	Belongs to the helicase family. UvrD subfamily
D3093_08525	COG1074	ATP-dependent DNA helicase activity
D3093_08535	COG0583	DNA-binding transcription factor activity
D3093_08545	COG3001	Fructosamine kinase
D3093_08550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3093_08555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D3093_08560	COG1573	uracil-dna glycosylase
D3093_08570	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3093_08580	COG0598	Magnesium transport protein CorA
D3093_08585	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D3093_08590	COG1872	DUF167
D3093_08610	COG1715	Restriction endonuclease
D3093_08625	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D3093_08735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3093_08740	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3093_08800	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3093_08805	COG4133	protoheme IX ABC transporter activity
D3093_08810	COG2985	domain, Protein
D3093_08845	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3093_08855	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D3093_08860	COG1138	Cytochrome C-type biogenesis protein
D3093_08865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3093_08870	COG3088	subunit of a heme lyase
D3093_08875	COG4235	cytochrome complex assembly
D3093_08880	COG0697	spore germination
D3093_08885	COG3339	Conserved Protein
D3093_08890	COG2897	thiosulfate sulfurtransferase activity
D3093_08905	COG0137	argininosuccinate synthase activity
D3093_08920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D3093_08930	COG1595	DNA-templated transcription, initiation
D3093_08935	COG3806	Anti-sigma factor
D3093_08960	COG0004	ammonium transporteR
D3093_08965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3093_08970	COG0297	glycogen (starch) synthase activity
D3093_08975	COG0481	GTPase activity
D3093_08985	COG0583	DNA-binding transcription factor activity
D3093_08995	COG0784	Response regulator, receiver
D3093_08995	COG3437	response regulator, receiver
D3093_09010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D3093_09015	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D3093_09020	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D3093_09040	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3093_09060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D3093_09065	COG0583	DNA-binding transcription factor activity
D3093_09070	COG0477	Major facilitator Superfamily
D3093_09085	COG1253	flavin adenine dinucleotide binding
D3093_09090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D3093_09110	COG2202	Pas domain
D3093_09110	COG2205	protein histidine kinase activity
D3093_09145	COG0803	Belongs to the bacterial solute-binding protein 9 family
D3093_09150	COG1121	(ABC) transporter
D3093_09155	COG1321	iron dependent repressor
D3093_09155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3093_09160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3093_09170	COG1278	Cold shock
D3093_09175	COG2204	response regulator
D3093_09180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D3093_09185	COG0756	dUTP diphosphatase activity
D3093_09195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3093_09205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D3093_09220	COG0745	RESPONSE REGULATOR receiver
D3093_09230	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3093_09240	COG0573	inorganic phosphate transmembrane transporter activity
D3093_09245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3093_09265	COG5002	protein histidine kinase activity
D3093_09270	COG0280	phosphate acetyltransferase
D3093_09270	COG0281	malic enzyme
D3093_09280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_09290	COG2217	Heavy metal translocating P-type atpase
D3093_09320	COG3278	Belongs to the heme-copper respiratory oxidase family
D3093_09340	COG2132	Multicopper oxidase
D3093_09355	COG1177	transmembrane transport
D3093_09360	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3093_09380	COG3842	ATPase activity
D3093_09385	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3093_09390	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3093_09395	COG0268	Binds directly to 16S ribosomal RNA
D3093_09400	COG1024	Enoyl-CoA hydratase
D3093_09410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D3093_09420	COG0859	PFAM glycosyl transferase family 9
D3093_09420	COG0457	Tetratricopeptide repeat
D3093_09425	COG2226	methyltransferase
D3093_09430	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3093_09440	COG4166	transmembrane transport
D3093_09445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D3093_09450	COG0039	L-malate dehydrogenase activity
D3093_09480	COG1592	Rubrerythrin
D3093_09495	COG0584	glycerophosphoryl diester phosphodiesterase
D3093_09500	COG1509	lysine 2,3-aminomutase activity
D3093_09510	COG2321	neutral zinc metallopeptidase
D3093_09520	COG1185	polyribonucleotide nucleotidyltransferase activity
D3093_09530	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D3093_09555	COG0779	Required for maturation of 30S ribosomal subunits
D3093_09560	COG2329	Antibiotic biosynthesis monooxygenase
D3093_09565	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D3093_09570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D3093_09575	COG1396	sequence-specific DNA binding
D3093_09580	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D3093_09585	COG1253	flavin adenine dinucleotide binding
D3093_09595	COG1702	phosphate starvation-inducible protein PhoH
D3093_09600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3093_09630	COG1214	PFAM Peptidase M22, glycoprotease
D3093_09635	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D3093_09645	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D3093_09670	COG0730	response to heat
D3093_09675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3093_09690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3093_09700	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3093_09705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D3093_09715	COG1121	(ABC) transporter
D3093_09720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3093_09740	COG0247	lactate metabolic process
D3093_09745	COG1139	Iron-sulfur cluster binding protein
D3093_09750	COG1556	Lactate utilization protein
D3093_09765	COG2205	protein histidine kinase activity
D3093_09770	COG0488	(ABC) transporter
D3093_09775	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D3093_09830	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D3093_09835	COG4395	Tim44
D3093_09845	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D3093_09850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D3093_09860	COG1981	membrane
D3093_09885	COG0237	dephospho-CoA kinase activity
D3093_09890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3093_09900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3093_09915	COG3411	Ferredoxin
D3093_09920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D3093_09925	COG0445	tRNA wobble uridine modification
D3093_09930	COG0357	Ribosomal RNA small subunit methyltransferase G
D3093_10005	COG0745	RESPONSE REGULATOR receiver
D3093_10025	COG1234	tRNA 3'-trailer cleavage
D3093_10035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3093_10040	COG0601	transmembrane transport
D3093_10070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3093_10070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_10075	COG1132	(ABC) transporter
D3093_10095	COG0438	transferase activity, transferring glycosyl groups
D3093_10120	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3093_10125	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D3093_10130	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D3093_10145	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_10150	COG1309	transcriptional regulator
D3093_10155	COG0110	maltose O-acetyltransferase activity
D3093_10170	COG3012	SEC-C Motif Domain Protein
D3093_10180	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D3093_10185	COG0180	Tryptophanyl-tRNA synthetase
D3093_10195	COG0784	Response regulator, receiver
D3093_10195	COG2205	protein histidine kinase activity
D3093_10200	COG0683	leucine binding
D3093_10235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3093_10245	COG1366	Belongs to the anti-sigma-factor antagonist family
D3093_10265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D3093_10270	COG0792	nuclease activity
D3093_10295	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D3093_10305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3093_10310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D3093_10315	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D3093_10320	COG1420	regulation of RNA biosynthetic process
D3093_10350	COG0443	Heat shock 70 kDa protein
D3093_10355	COG0484	heat shock protein binding
D3093_10360	COG3706	GGDEF domain
D3093_10370	COG4181	ATPase activity
D3093_10385	COG0667	Aldo Keto reductase
D3093_10390	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D3093_10395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3093_10400	COG0347	Belongs to the P(II) protein family
D3093_10405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3093_10430	COG0606	chelatase, subunit chli
D3093_10440	COG0747	negative chemotaxis
D3093_10450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3093_10455	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D3093_10475	COG3685	Protein conserved in bacteria
D3093_10495	COG1013	pyruvate-flavodoxin oxidoreductase activity
D3093_10500	COG0674	pyruvate-flavodoxin oxidoreductase activity
D3093_10500	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D3093_10505	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3093_10510	COG2205	protein histidine kinase activity
D3093_10510	COG2202	Pas domain
D3093_10515	COG0693	protein deglycase activity
D3093_10520	COG2224	Isocitrate lyase
D3093_10525	COG1396	sequence-specific DNA binding
D3093_10525	COG3800	Transcriptional regulator
D3093_10540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3093_10545	COG3437	response regulator, receiver
D3093_10545	COG0784	Response regulator, receiver
D3093_10550	COG0668	transmembrane transport
D3093_10560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3093_10585	COG1612	heme a metabolic process
D3093_10590	COG0493	'glutamate synthase
D3093_10590	COG0543	2 iron, 2 sulfur cluster binding
D3093_10595	COG3772	lysozyme
D3093_10600	COG5425	PFAM Usg family protein
D3093_10605	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3093_10610	COG0459	protein refolding
D3093_10615	COG0753	catalase activity
D3093_10620	COG1858	cytochrome C peroxidase
D3093_10625	COG3005	denitrification pathway
D3093_10645	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3093_10655	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D3093_10660	COG1842	Phage shock protein A
D3093_10675	COG0784	Response regulator, receiver
D3093_10675	COG3437	response regulator, receiver
D3093_10685	COG0671	phosphoesterase, PA-phosphatase related
D3093_10740	COG0747	negative chemotaxis
D3093_10745	COG0601	transmembrane transport
D3093_10750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3093_10755	COG0444	Belongs to the ABC transporter superfamily
D3093_10775	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D3093_10785	COG0302	gtp cyclohydrolase
D3093_10790	COG2967	ApaG domain
D3093_10820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3093_10835	COG5002	protein histidine kinase activity
D3093_10850	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3093_10855	COG4191	Histidine kinase
D3093_10855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3093_10865	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3093_10875	COG2885	chlorophyll binding
D3093_10905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3093_10935	COG0181	hydroxymethylbilane synthase activity
D3093_10955	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D3093_10960	COG2350	Protein conserved in bacteria
D3093_10975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3093_10990	COG5508	conserved small protein
D3093_10995	COG0501	Belongs to the peptidase M48B family
D3093_11010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D3093_11010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3093_11020	COG0138	bifunctional purine biosynthesis protein purh
D3093_11040	COG2264	protein methyltransferase activity
D3093_11045	COG2902	Dehydrogenase
D3093_11050	COG2770	Histidine kinase
D3093_11050	COG3437	response regulator, receiver
D3093_11060	COG0840	transmembrane signaling receptor activity
D3093_11070	COG0679	Auxin Efflux Carrier
D3093_11075	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3093_11090	COG3118	belongs to the thioredoxin family
D3093_11095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3093_11100	COG2835	tetraacyldisaccharide 4'-kinase activity
D3093_11140	COG1285	pathogenesis
D3093_11145	COG2814	Major facilitator Superfamily
D3093_11155	COG0784	Response regulator, receiver
D3093_11155	COG2205	protein histidine kinase activity
D3093_11185	COG0395	ABC-type sugar transport system, permease component
D3093_11190	COG3842	ATPase activity
D3093_11195	COG0625	glutathione transferase activity
D3093_11210	COG0513	Belongs to the DEAD box helicase family
D3093_11230	COG2205	protein histidine kinase activity
D3093_11230	COG5002	protein histidine kinase activity
D3093_11230	COG0784	Response regulator, receiver
D3093_11235	COG4191	Histidine kinase
D3093_11240	COG1366	Belongs to the anti-sigma-factor antagonist family
D3093_11250	COG0745	RESPONSE REGULATOR receiver
D3093_11270	COG0745	RESPONSE REGULATOR receiver
D3093_11285	COG1366	Belongs to the anti-sigma-factor antagonist family
D3093_11290	COG0840	transmembrane signaling receptor activity
D3093_11295	COG2201	protein-glutamate methylesterase activity
D3093_11300	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D3093_11310	COG0840	transmembrane signaling receptor activity
D3093_11315	COG0835	chemotaxis
D3093_11320	COG2198	Histidine kinase
D3093_11320	COG0643	Histidine kinase
D3093_11325	COG0745	RESPONSE REGULATOR receiver
D3093_11335	COG5002	protein histidine kinase activity
D3093_11345	COG2176	DNA-directed DNA polymerase activity
D3093_11345	COG5002	protein histidine kinase activity
D3093_11350	COG0745	RESPONSE REGULATOR receiver
D3093_11365	COG2917	probably involved in intracellular septation
D3093_11375	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D3093_11380	COG0552	protein localization to endoplasmic reticulum
D3093_11385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3093_11390	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D3093_11440	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D3093_11455	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D3093_11460	COG3706	GGDEF domain
D3093_11465	COG2205	protein histidine kinase activity
D3093_11470	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3093_11485	COG0045	succinate-CoA ligase (ADP-forming) activity
D3093_11490	COG0039	L-malate dehydrogenase activity
D3093_11505	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D3093_11510	COG2076	Multidrug Resistance protein
D3093_11520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3093_11525	COG1199	ATP-dependent helicase activity
D3093_11525	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3093_11540	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D3093_11560	COG2084	Dehydrogenase
D3093_11570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3093_11605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3093_11805	COG0167	dihydroorotate dehydrogenase activity
D3093_11815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D3093_11820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3093_11825	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3093_11915	COG3547	Transposase (IS116 IS110 IS902 family)
D3093_11955	COG1518	maintenance of DNA repeat elements
D3093_11960	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D3093_11970	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3093_11975	COG2304	oxidoreductase activity
D3093_12005	COG1136	(ABC) transporter
D3093_12060	COG0583	DNA-binding transcription factor activity
D3093_12065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3093_12070	COG1024	Enoyl-CoA hydratase
D3093_12085	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_12115	COG1902	pentaerythritol trinitrate reductase activity
D3093_12160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3093_12165	COG1116	anion transmembrane transporter activity
D3093_12170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3093_12175	COG0583	DNA-binding transcription factor activity
D3093_12225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3093_12230	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3093_12240	COG0783	Belongs to the Dps family
D3093_12250	COG0492	ferredoxin-NADP+ reductase activity
D3093_12265	COG3660	Nucleoside-diphosphate-sugar epimerase
D3093_12270	COG1522	sequence-specific DNA binding
D3093_12280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3093_12285	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3093_12310	COG1674	ftsk spoiiie
D3093_12320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3093_12330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3093_12335	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_12340	COG1238	metal cluster binding
D3093_12360	COG1012	belongs to the aldehyde dehydrogenase family
D3093_12390	COG2205	protein histidine kinase activity
D3093_12390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3093_12410	COG5002	protein histidine kinase activity
D3093_12420	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3093_12430	COG3279	Response regulator of the LytR AlgR family
D3093_12445	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D3093_12455	COG1902	pentaerythritol trinitrate reductase activity
D3093_12475	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D3093_12485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3093_12490	COG0047	phosphoribosylformylglycinamidine synthase activity
D3093_12495	COG0583	DNA-binding transcription factor activity
D3093_12505	COG2258	MOSC domain
D3093_12515	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3093_12520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3093_12545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D3093_12565	COG0024	Methionine aminopeptidase
D3093_12570	COG1489	DNA binding
D3093_12575	COG1058	Belongs to the CinA family
D3093_12575	COG1546	Belongs to the CinA family
D3093_12610	COG0124	histidyl-tRNA synthetase
D3093_12615	COG0418	dihydroorotase activity
D3093_12620	COG1570	exodeoxyribonuclease VII activity
D3093_12640	COG0590	tRNA wobble adenosine to inosine editing
D3093_12645	COG3360	Dodecin
D3093_12650	COG1187	pseudouridine synthase activity
D3093_12655	COG0742	ribosomal rna small subunit methyltransferase
D3093_12670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3093_12680	COG2084	Dehydrogenase
D3093_12690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3093_12695	COG3958	Transketolase
D3093_12700	COG3959	Transketolase, thiamine diphosphate binding domain
D3093_12705	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_12710	COG0583	DNA-binding transcription factor activity
D3093_12715	COG1309	transcriptional regulator
D3093_12770	COG1749	Flagellar hook protein flgE
D3093_12775	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3093_12785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3093_12795	COG0251	oxidation-reduction process
D3093_12805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3093_12815	COG0747	negative chemotaxis
D3093_12825	COG0583	DNA-binding transcription factor activity
D3093_12835	COG4221	oxidoreductase activity
D3093_12850	COG2201	protein-glutamate methylesterase activity
D3093_12860	COG0747	negative chemotaxis
D3093_12885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3093_12890	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_12925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D3093_12935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3093_12940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3093_12970	COG0667	Aldo Keto reductase
D3093_12975	COG5265	(ABC) transporter
D3093_12980	COG3284	Transcriptional regulator
D3093_12985	COG3199	ATP-NAD kinase
D3093_12990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3093_12995	COG0022	dehydrogenase e1 component
D3093_13000	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3093_13000	COG0596	Alpha beta hydrolase
D3093_13040	COG0644	oxidoreductase
D3093_13055	COG0745	RESPONSE REGULATOR receiver
D3093_13060	COG0784	Response regulator, receiver
D3093_13060	COG5002	protein histidine kinase activity
D3093_13065	COG2010	Cytochrome c
D3093_13080	COG1309	transcriptional regulator
D3093_13085	COG0604	alcohol dehydrogenase
D3093_13105	COG3547	Transposase (IS116 IS110 IS902 family)
D3093_13110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D3093_13130	COG0166	Belongs to the GPI family
D3093_13140	COG0612	Peptidase, M16
D3093_13145	COG0612	Peptidase, M16
D3093_13155	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3093_13160	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D3093_13165	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3093_13170	COG0196	riboflavin kinase activity
D3093_13175	COG2030	dehydratase
D3093_13185	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D3093_13210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3093_13215	COG2703	oxygen carrier activity
D3093_13240	COG0590	tRNA wobble adenosine to inosine editing
D3093_13250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3093_13265	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D3093_13290	COG1686	Belongs to the peptidase S11 family
D3093_13305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3093_13310	COG0746	molybdenum cofactor guanylyltransferase activity
D3093_13335	COG0243	molybdopterin cofactor binding
D3093_13335	COG3383	formate dehydrogenase (NAD+) activity
D3093_13340	COG0437	4 iron, 4 sulfur cluster binding
D3093_13365	COG0235	Class ii aldolase
D3093_13375	COG3384	dioxygenase
D3093_13385	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3093_13390	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3093_13395	COG0356	it plays a direct role in the translocation of protons across the membrane
D3093_13405	COG1999	signal sequence binding
D3093_13420	COG1702	phosphate starvation-inducible protein PhoH
D3093_13430	COG2894	cell division
D3093_13435	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D3093_13455	COG0840	transmembrane signaling receptor activity
D3093_13460	COG4948	Mandelate Racemase Muconate Lactonizing
D3093_13465	COG1104	cysteine desulfurase activity
D3093_13475	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3093_13490	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D3093_13515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3093_13520	COG1278	Cold shock
D3093_13530	COG5002	protein histidine kinase activity
D3093_13530	COG0784	Response regulator, receiver
D3093_13530	COG2205	protein histidine kinase activity
D3093_13555	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D3093_13610	COG5420	small protein containing a coiled-coil domain
D3093_13625	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D3093_13630	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D3093_13685	COG0121	glutamine amidotransferase
D3093_13700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3093_13725	COG5554	nitrogen fixation
D3093_13740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3093_13760	COG1309	transcriptional regulator
D3093_13770	COG1131	(ABC) transporter
D3093_13775	COG0842	Transport permease protein
D3093_13780	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D3093_13790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D3093_13800	COG0277	FAD linked oxidase domain protein
D3093_13805	COG0277	FAD linked oxidase domain protein
D3093_13810	COG0247	lactate metabolic process
D3093_13830	COG1960	acyl-CoA dehydrogenase activity
D3093_13845	COG0277	FAD linked oxidase domain protein
D3093_13850	COG0009	L-threonylcarbamoyladenylate synthase
D3093_13855	COG1192	Involved in chromosome partitioning
D3093_13865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3093_13870	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D3093_13885	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D3093_13890	COG2945	thiolester hydrolase activity
D3093_13895	COG1045	serine acetyltransferase
D3093_13910	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D3093_13915	COG0633	Ferredoxin
D3093_13920	COG0482	sulfurtransferase activity
D3093_13935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3093_13960	COG4221	oxidoreductase activity
D3093_13975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3093_13975	COG2010	Cytochrome c
D3093_13980	COG2080	2 iron, 2 sulfur cluster binding
D3093_13990	COG5002	protein histidine kinase activity
D3093_14000	COG0745	RESPONSE REGULATOR receiver
D3093_14025	COG0432	Pfam Uncharacterised protein family UPF0047
D3093_14035	COG2951	lytic endotransglycosylase activity
D3093_14105	COG0114	fumarate hydratase activity
D3093_14170	COG2205	protein histidine kinase activity
D3093_14175	COG2927	DNA polymerase III (CHI subunit)
D3093_14180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3093_14210	COG0741	lytic transglycosylase activity
D3093_14235	COG1561	YicC-like family, N-terminal region
D3093_14240	COG0300	oxidoreductase activity
D3093_14245	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3093_14250	COG3932	Exopolysaccharide synthesis, ExoD
D3093_14255	COG0488	(ABC) transporter
D3093_14260	COG0105	UTP biosynthetic process
D3093_14275	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D3093_14280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D3093_14290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3093_14295	COG0628	permease
D3093_14305	COG0300	oxidoreductase activity
D3093_14310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D3093_14325	COG3025	triphosphatase activity
D3093_14335	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3093_14340	COG0248	Ppx GppA phosphatase
D3093_14350	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D3093_14355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D3093_14375	COG3447	MASE1 domain protein
D3093_14375	COG5001	Diguanylate cyclase
D3093_14375	COG5002	protein histidine kinase activity
D3093_14380	COG2202	Pas domain
D3093_14380	COG2205	protein histidine kinase activity
D3093_14385	COG0784	Response regulator, receiver
D3093_14395	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D3093_14400	COG0793	Belongs to the peptidase S41A family
D3093_14405	COG0557	exoribonuclease II activity
D3093_14420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3093_14425	COG0758	DNA mediated transformation
D3093_14445	COG2814	Major facilitator Superfamily
D3093_14480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3093_14480	COG2205	protein histidine kinase activity
D3093_14485	COG0745	RESPONSE REGULATOR receiver
D3093_14520	COG0581	inorganic phosphate transmembrane transporter activity
D3093_14535	COG3842	ATPase activity
D3093_14545	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3093_14550	COG1732	Glycine betaine
D3093_14555	COG1174	glycine betaine transport
D3093_14560	COG1125	glycine betaine transport
D3093_14565	COG1174	glycine betaine transport
D3093_14575	COG1652	LysM domain
D3093_14580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3093_14590	COG1024	Enoyl-CoA hydratase
D3093_14595	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D3093_14600	COG1609	Transcriptional regulator
D3093_14605	COG3265	gluconokinase activity
D3093_14615	COG3971	2-oxopent-4-enoate hydratase activity
D3093_14620	COG1609	Transcriptional regulator
D3093_14625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3093_14630	COG1126	abc transporter atp-binding protein
D3093_14640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3093_14645	COG0765	amino acid transport
D3093_14650	COG0765	amino acid transport
D3093_14655	COG0303	'Molybdopterin
D3093_14680	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_14685	COG0730	response to heat
D3093_14700	COG0717	Belongs to the dCTP deaminase family
D3093_14710	COG0625	glutathione transferase activity
D3093_14715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3093_14735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3093_14735	COG2813	Specifically methylates the guanine in position
D3093_14740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3093_14750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3093_14755	COG0287	Prephenate dehydrogenase
D3093_14760	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D3093_14770	COG0583	DNA-binding transcription factor activity
D3093_14780	COG3634	alkyl hydroperoxide reductase activity
D3093_14785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3093_14790	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3093_14795	COG2080	2 iron, 2 sulfur cluster binding
D3093_14805	COG1988	membrane-bound metal-dependent
D3093_14825	COG0745	RESPONSE REGULATOR receiver
D3093_14835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3093_14840	COG0540	Belongs to the ATCase OTCase family
D3093_14855	COG0583	DNA-binding transcription factor activity
D3093_14870	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D3093_14885	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D3093_14895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3093_14900	COG0154	amidase activity
D3093_14905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3093_14925	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D3093_15055	COG1802	Transcriptional regulator
D3093_15055	COG4626	Terminase
D3093_15200	COG0714	Associated with various cellular activities
D3093_15220	COG0617	tRNA 3'-terminal CCA addition
D3093_15225	COG0408	coproporphyrinogen oxidase activity
D3093_15230	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D3093_15245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D3093_15245	COG2857	Cytochrome c1
D3093_15265	COG0640	Transcriptional regulator
D3093_15275	COG0425	Belongs to the sulfur carrier protein TusA family
D3093_15295	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D3093_15305	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D3093_15340	COG4372	Transposase
D3093_15390	COG1136	(ABC) transporter
D3093_15390	COG0577	efflux transmembrane transporter activity
D3093_15395	COG1136	(ABC) transporter
D3093_15395	COG0577	efflux transmembrane transporter activity
D3093_15435	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3093_15440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3093_15450	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D3093_15480	COG0667	Aldo Keto reductase
D3093_15485	COG0583	DNA-binding transcription factor activity
D3093_15490	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D3093_15545	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D3093_15550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3093_15555	COG1127	ABC transporter
D3093_15575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3093_15580	COG1271	oxidase subunit
D3093_15585	COG1294	oxidase, subunit
D3093_15600	COG0300	oxidoreductase activity
D3093_15615	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_15640	COG2089	acid synthase
D3093_15645	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D3093_15670	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_15675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3093_15680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3093_15695	COG0859	PFAM glycosyl transferase family 9
D3093_15695	COG0457	Tetratricopeptide repeat
D3093_15705	COG0457	Tetratricopeptide repeat
D3093_15705	COG0859	PFAM glycosyl transferase family 9
D3093_15755	COG0784	Response regulator, receiver
D3093_15790	COG1228	amidohydrolase
D3093_15805	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D3093_15820	COG2226	methyltransferase
D3093_15830	COG0747	negative chemotaxis
D3093_15835	COG0601	transmembrane transport
D3093_15840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3093_15845	COG0444	Belongs to the ABC transporter superfamily
D3093_15850	COG4608	Belongs to the ABC transporter superfamily
D3093_15890	COG1666	GTP binding
D3093_15945	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3093_15950	COG1132	(ABC) transporter
D3093_15955	COG4191	Histidine kinase
D3093_15980	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D3093_15990	COG2264	protein methyltransferase activity
D3093_15995	COG0583	DNA-binding transcription factor activity
D3093_16000	COG0655	NAD(P)H dehydrogenase (quinone) activity
D3093_16005	COG0435	Glutathione S-transferase
D3093_16015	COG2197	response regulator
D3093_16025	COG0492	ferredoxin-NADP+ reductase activity
D3093_16045	COG0484	heat shock protein binding
D3093_16065	COG3038	cytochrome b561
D3093_16085	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3093_16095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3093_16105	COG1846	Transcriptional regulator
D3093_16115	COG3920	Histidine kinase
D3093_16130	COG1758	RNA polymerase activity
D3093_16145	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D3093_16150	COG0736	holo-[acyl-carrier-protein] synthase activity
D3093_16155	COG0681	Belongs to the peptidase S26 family
D3093_16165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D3093_16175	COG3768	UPF0283 membrane protein
D3093_16195	COG0740	serine-type endopeptidase activity
D3093_16200	COG1215	transferase activity, transferring glycosyl groups
D3093_16205	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3093_16210	COG1566	PFAM secretion protein HlyD family protein
D3093_16215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3093_16225	COG2307	Protein conserved in bacteria
D3093_16225	COG2308	Evidence 4 Homologs of previously reported genes of
D3093_16245	COG2017	converts alpha-aldose to the beta-anomer
D3093_16285	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D3093_16295	COG0513	Belongs to the DEAD box helicase family
D3093_16315	COG0187	DNA topoisomerase II activity
D3093_16320	COG1607	acyl-coa hydrolase
D3093_16325	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D3093_16330	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3093_16335	COG0022	dehydrogenase e1 component
D3093_16335	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3093_16340	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3093_16345	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3093_16350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3093_16355	COG2867	negative regulation of translational initiation
D3093_16395	COG2204	response regulator
D3093_16400	COG0569	domain protein
D3093_16415	COG1923	regulation of RNA biosynthetic process
D3093_16420	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3093_16435	COG0483	inositol monophosphate 1-phosphatase activity
D3093_16450	COG3956	TIGRFAM MazG family protein
D3093_16455	COG3260	NADH ubiquinone oxidoreductase 20
D3093_16460	COG0649	NAD binding
D3093_16465	COG0651	ATP synthesis coupled electron transport
D3093_16475	COG0650	Formate hydrogenlyase subunit 4
D3093_16480	COG0651	ATP synthesis coupled electron transport
D3093_16485	COG2183	response to ionizing radiation
D3093_16495	COG1280	lysine exporter protein (LysE YggA)
D3093_16525	COG0393	Putative heavy-metal-binding
D3093_16530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3093_16545	COG4166	transmembrane transport
D3093_16550	COG0625	glutathione transferase activity
D3093_16555	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3093_16560	COG0366	Alpha amylase catalytic
D3093_16580	COG0840	transmembrane signaling receptor activity
D3093_16615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3093_16625	COG0583	DNA-binding transcription factor activity
D3093_16630	COG4336	lyase activity
D3093_16650	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D3093_16655	COG1984	allophanate hydrolase subunit 2
D3093_16660	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D3093_16675	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D3093_16680	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3093_16685	COG0058	SHG alpha-glucan phosphorylase activity
D3093_16740	COG5002	protein histidine kinase activity
D3093_16745	COG0745	RESPONSE REGULATOR receiver
D3093_16780	COG1959	2 iron, 2 sulfur cluster binding
D3093_16785	COG0719	Fe-S assembly protein
D3093_16790	COG0396	ATPase activity
D3093_16795	COG0719	Fe-S assembly protein
D3093_16800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3093_16805	COG0822	iron-sulfur transferase activity
D3093_16815	COG0316	Belongs to the HesB IscA family
D3093_16825	COG0308	aminopeptidase N
D3093_16845	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3093_16880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3093_16885	COG0697	spore germination
D3093_16895	COG2814	Major facilitator Superfamily
D3093_16900	COG0583	DNA-binding transcription factor activity
D3093_16915	COG3383	formate dehydrogenase (NAD+) activity
D3093_16920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3093_16940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3093_16945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3093_16965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3093_16975	COG0129	dihydroxy-acid dehydratase activity
D3093_17085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D3093_17090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3093_17095	COG0534	Mate efflux family protein
D3093_17135	COG0629	single-stranded DNA binding
D3093_17140	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3093_17175	COG1562	ergosterol biosynthetic process
D3093_17180	COG1562	ergosterol biosynthetic process
D3093_17185	COG1233	COG1233 Phytoene dehydrogenase and related
D3093_17195	COG3737	Protein of unknown function (DUF498/DUF598)
D3093_17205	COG1862	Preprotein translocase
D3093_17225	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3093_17235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3093_17245	COG0805	protein transport
D3093_17250	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3093_17255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3093_17260	COG3842	ATPase activity
D3093_17265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D3093_17270	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D3093_17275	COG1994	Peptidase M50
D3093_17280	COG1472	Belongs to the glycosyl hydrolase 3 family
D3093_17295	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D3093_17300	COG0316	Belongs to the HesB IscA family
D3093_17305	COG0708	Exodeoxyribonuclease III
D3093_17320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D3093_17325	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3093_17330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D3093_17350	COG0270	DNA (cytosine-5-)-methyltransferase activity
D3093_17380	COG0582	viral genome integration into host DNA
D3093_17390	COG0066	3-isopropylmalate dehydratase activity
D3093_17395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3093_17400	COG1053	succinate dehydrogenase
D3093_17405	COG1335	isochorismatase
D3093_17450	COG0683	leucine binding
D3093_17455	COG2188	Transcriptional regulator
D3093_17505	COG5002	protein histidine kinase activity
D3093_17505	COG2198	Histidine kinase
D3093_17505	COG0784	Response regulator, receiver
D3093_17515	COG4548	von Willebrand factor, type A
D3093_17525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3093_17535	COG0444	Belongs to the ABC transporter superfamily
D3093_17540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3093_17545	COG0601	transmembrane transport
D3093_17625	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D3093_17785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3093_17790	COG3806	Anti-sigma factor
D3093_17795	COG1595	DNA-templated transcription, initiation
D3093_17805	COG1882	Formate acetyltransferase
D3093_17815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3093_17815	COG3008	intermembrane lipid transfer
D3093_17820	COG2995	paraquat-inducible protein a
D3093_17830	COG0859	PFAM glycosyl transferase family 9
D3093_17830	COG0457	Tetratricopeptide repeat
D3093_17835	COG0281	malic enzyme
D3093_17835	COG0280	phosphate acetyltransferase
D3093_17840	COG1301	dicarboxylic acid transport
D3093_17845	COG4191	Histidine kinase
D3093_17850	COG2204	response regulator
D3093_17865	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3093_17865	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3093_17870	COG1268	BioY protein
D3093_17875	COG4770	biotin carboxylase activity
D3093_17880	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3093_17890	COG1794	racemase activity, acting on amino acids and derivatives
D3093_17910	COG0519	Catalyzes the synthesis of GMP from XMP
D3093_17915	COG1247	-acetyltransferase
D3093_17940	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D3093_17950	COG3813	Protein conserved in bacteria
D3093_17955	COG0357	Ribosomal RNA small subunit methyltransferase G
D3093_17955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3093_17990	COG4178	(ABC) transporter
D3093_18015	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D3093_18030	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D3093_18035	COG0437	4 iron, 4 sulfur cluster binding
D3093_18040	COG5557	Pfam Polysulphide reductase, NrfD
D3093_18045	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D3093_18050	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D3093_18055	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3093_18075	COG0298	carbon dioxide binding
D3093_18090	COG0375	protein maturation
D3093_18100	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D3093_18110	COG0309	Hydrogenase expression formation protein (HypE)
D3093_18120	COG0793	Belongs to the peptidase S41A family
D3093_18125	COG1278	Cold shock
D3093_18130	COG3012	SEC-C Motif Domain Protein
D3093_18135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3093_18135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_18145	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D3093_18165	COG1194	a g-specific adenine glycosylase
D3093_18180	COG1196	nuclear chromosome segregation
D3093_18195	COG3047	cAMP biosynthetic process
D3093_18210	COG1960	acyl-CoA dehydrogenase activity
D3093_18215	COG1024	Enoyl-CoA hydratase
D3093_18215	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3093_18220	COG0183	Belongs to the thiolase family
D3093_18235	COG2373	Large extracellular alpha-helical protein
D3093_18240	COG2205	protein histidine kinase activity
D3093_18240	COG2202	Pas domain
D3093_18245	COG0436	Aminotransferase
D3093_18260	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3093_18270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3093_18275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3093_18280	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3093_18285	COG1737	Transcriptional regulator
D3093_18285	COG0837	glucose binding
D3093_18300	COG0386	Belongs to the glutathione peroxidase family
D3093_18315	COG3264	Mechanosensitive ion channel
D3093_18315	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D3093_18365	COG1063	alcohol dehydrogenase
D3093_18370	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3093_18380	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3093_18385	COG2721	sulfolactate sulfo-lyase activity
D3093_18390	COG0246	Mannitol dehydrogenase
D3093_18415	COG2358	TRAP transporter, solute receptor (TAXI family
D3093_18420	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D3093_18425	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D3093_18430	COG0583	DNA-binding transcription factor activity
D3093_18440	COG2391	methyltransferase activity
D3093_18455	COG3842	ATPase activity
D3093_18460	COG4149	molybdate abc transporter
D3093_18465	COG1840	ABC-type Fe3 transport system, periplasmic component
D3093_18480	COG1686	Belongs to the peptidase S11 family
D3093_18520	COG1396	sequence-specific DNA binding
D3093_18525	COG1766	The M ring may be actively involved in energy transduction
D3093_18535	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3093_18540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3093_18545	COG2204	response regulator
D3093_18555	COG0552	protein localization to endoplasmic reticulum
D3093_18590	COG0745	RESPONSE REGULATOR receiver
D3093_18600	COG0583	DNA-binding transcription factor activity
D3093_18615	COG2198	Histidine kinase
D3093_18615	COG0643	Histidine kinase
D3093_18615	COG0784	Response regulator, receiver
D3093_18620	COG0835	chemotaxis
D3093_18625	COG0784	Response regulator, receiver
D3093_18625	COG0643	Histidine kinase
D3093_18625	COG2198	Histidine kinase
D3093_18650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3093_18655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3093_18660	COG1360	Flagellar Motor Protein
D3093_18665	COG2308	Evidence 4 Homologs of previously reported genes of
D3093_18685	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3093_18685	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3093_18690	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3093_18695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3093_18700	COG1381	Involved in DNA repair and RecF pathway recombination
D3093_18705	COG5001	Diguanylate cyclase
D3093_18740	COG2884	Cell division ATP-binding protein ftsE
D3093_18770	COG0586	Pfam SNARE associated Golgi protein
D3093_18775	COG0505	Belongs to the CarA family
D3093_18785	COG3135	benzoate transporter
D3093_18790	COG0583	DNA-binding transcription factor activity
D3093_18795	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3093_18810	COG0488	(ABC) transporter
D3093_18820	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3093_18840	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D3093_18850	COG0612	Peptidase, M16
D3093_18895	COG2223	nitrite transmembrane transporter activity
D3093_18900	COG0716	FMN binding
D3093_18915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3093_18925	COG1392	Phosphate transport regulator
D3093_18930	COG0306	phosphate transporter
D3093_18965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_18975	COG4191	Histidine kinase
D3093_18975	COG0784	Response regulator, receiver
D3093_18990	COG1283	sodium-dependent phosphate transmembrane transporter activity
D3093_19000	COG0583	DNA-binding transcription factor activity
D3093_19015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D3093_19025	COG0288	reversible hydration of carbon dioxide
D3093_19040	COG4948	Mandelate Racemase Muconate Lactonizing
D3093_19045	COG0583	DNA-binding transcription factor activity
D3093_19050	COG0625	glutathione transferase activity
D3093_19100	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D3093_19110	COG1335	isochorismatase
D3093_19115	COG4191	Histidine kinase
D3093_19120	COG4566	intracellular signal transduction
D3093_19165	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D3093_19175	COG1396	sequence-specific DNA binding
D3093_19185	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3093_19200	COG3547	Transposase (IS116 IS110 IS902 family)
D3093_19215	COG3920	Histidine kinase
D3093_19250	COG4651	solute:proton antiporter activity
D3093_19250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3093_19260	COG3243	poly(R)-hydroxyalkanoic acid synthase
D3093_19265	COG3932	Exopolysaccharide synthesis, ExoD
D3093_19335	COG0784	Response regulator, receiver
D3093_19335	COG2198	Histidine kinase
D3093_19335	COG2205	protein histidine kinase activity
D3093_19340	COG5002	protein histidine kinase activity
D3093_19340	COG2205	protein histidine kinase activity
D3093_19340	COG0784	Response regulator, receiver
D3093_19345	COG2204	response regulator
D3093_19350	COG0745	RESPONSE REGULATOR receiver
D3093_19365	COG2244	polysaccharide biosynthetic process
D3093_19380	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D3093_19400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D3093_19425	COG1216	Glycosyl transferase, family 2
D3093_19495	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D3093_19500	COG1082	Xylose isomerase domain protein TIM barrel
D3093_19525	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3093_19530	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_19540	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3093_19545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3093_19610	COG3328	transposase activity
D3093_19705	COG1881	PFAM PEBP family protein
D3093_19725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_19745	COG0484	heat shock protein binding
D3093_19770	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D3093_19770	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3093_19790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3093_19810	COG0071	Belongs to the small heat shock protein (HSP20) family
D3093_19825	COG0542	response to heat
D3093_19835	COG0459	protein refolding
D3093_19840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3093_19845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D3093_19880	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_19890	COG0583	DNA-binding transcription factor activity
D3093_19940	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3093_19945	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D3093_19950	COG1301	dicarboxylic acid transport
D3093_19955	COG2828	Protein conserved in bacteria
D3093_19960	COG0583	DNA-binding transcription factor activity
D3093_19965	COG0583	DNA-binding transcription factor activity
D3093_20015	COG0739	heme binding
D3093_20030	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D3093_20045	COG0745	RESPONSE REGULATOR receiver
D3093_20050	COG0642	Histidine kinase
D3093_20060	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D3093_20065	COG1660	Displays ATPase and GTPase activities
D3093_20070	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3093_20070	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3093_20075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3093_20095	COG4206	TonB-dependent receptor
D3093_20105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3093_20180	COG3547	Transposase (IS116 IS110 IS902 family)
D3093_20185	COG1116	anion transmembrane transporter activity
D3093_20185	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3093_20210	COG0784	Response regulator, receiver
D3093_20210	COG2205	protein histidine kinase activity
D3093_20210	COG5002	protein histidine kinase activity
D3093_20225	COG1695	Transcriptional regulator
D3093_20230	COG4607	ABC-type enterochelin transport system periplasmic component
D3093_20235	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3093_20240	COG4605	iron ion homeostasis
D3093_20245	COG4604	ABC transporter, ATP-binding protein
D3093_20260	COG3128	pkhd-type hydroxylase
D3093_20265	COG4774	siderophore transport
D3093_20285	COG0671	phosphoesterase, PA-phosphatase related
D3093_20290	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D3093_20305	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D3093_20310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3093_20315	COG0842	Transport permease protein
D3093_20320	COG2137	regulation of response to DNA damage stimulus
D3093_20330	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D3093_20340	COG1703	isobutyryl-CoA mutase activity
D3093_20350	COG5265	(ABC) transporter
D3093_20355	COG0840	transmembrane signaling receptor activity
D3093_20370	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D3093_20375	COG1272	protein, Hemolysin III
D3093_20380	COG0542	response to heat
D3093_20400	COG2890	protein-(glutamine-N5) methyltransferase activity
D3093_20410	COG2852	Protein conserved in bacteria
D3093_20420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D3093_20425	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D3093_20440	COG2070	2-Nitropropane dioxygenase
D3093_20445	COG0527	aspartate kinase activity
D3093_20450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3093_20455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3093_20460	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3093_20465	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D3093_20470	COG1137	ATPase activity
D3093_20505	COG2223	nitrite transmembrane transporter activity
D3093_20525	COG1214	PFAM Peptidase M22, glycoprotease
D3093_20525	COG0456	acetyltransferase
D3093_20570	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_20580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3093_20605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3093_20610	COG2864	formate dehydrogenase
D3093_20615	COG0437	4 iron, 4 sulfur cluster binding
D3093_20620	COG0243	molybdopterin cofactor binding
D3093_20620	COG3383	formate dehydrogenase (NAD+) activity
D3093_20660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D3093_20680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3093_20690	COG3648	Uricase
D3093_20690	COG3195	allantoin biosynthetic process
D3093_20705	COG0583	DNA-binding transcription factor activity
D3093_20710	COG1609	Transcriptional regulator
D3093_20760	COG1032	radical SAM domain protein
D3093_20770	COG0791	NLP P60 protein
D3093_20775	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3093_20775	COG1648	precorrin-2 dehydrogenase activity
D3093_20780	COG0243	molybdopterin cofactor binding
D3093_20785	COG2146	nitrite reductase [NAD(P)H] activity
D3093_20790	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3093_20795	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3093_20805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3093_20805	COG1116	anion transmembrane transporter activity
D3093_20810	COG3707	response regulator
D3093_20825	COG0251	oxidation-reduction process
D3093_20830	COG0583	DNA-binding transcription factor activity
D3093_20845	COG1475	DNA binding
D3093_20850	COG1192	Involved in chromosome partitioning
D3093_20865	COG0420	3'-5' exonuclease activity
D3093_20905	COG1942	4-Oxalocrotonate Tautomerase
D3093_20910	COG0235	Class ii aldolase
D3093_20930	COG0243	molybdopterin cofactor binding
D3093_20930	COG3383	formate dehydrogenase (NAD+) activity
D3093_20935	COG0437	4 iron, 4 sulfur cluster binding
D3093_20940	COG2864	formate dehydrogenase
D3093_20945	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3093_20955	COG2205	protein histidine kinase activity
D3093_20960	COG0745	RESPONSE REGULATOR receiver
D3093_20975	COG0840	transmembrane signaling receptor activity
D3093_20985	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3093_20995	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D3093_21025	COG2027	D-alanyl-D-alanine carboxypeptidase
D3093_21035	COG2091	lysine biosynthetic process via aminoadipic acid
D3093_21040	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3093_21045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3093_21055	COG2111	Na H antiporter
D3093_21055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3093_21060	COG1006	Multisubunit Na H antiporter MnhC subunit
D3093_21065	COG0651	ATP synthesis coupled electron transport
D3093_21070	COG1863	multisubunit Na H antiporter MnhE subunit
D3093_21075	COG2212	antiporter activity
D3093_21080	COG1320	monovalent cation:proton antiporter activity
D3093_21120	COG4615	Cyclic peptide transporter
D3093_21155	COG0683	leucine binding
D3093_21180	COG3842	ATPase activity
D3093_21190	COG1175	transmembrane transport
D3093_21210	COG1024	Enoyl-CoA hydratase
D3093_21225	COG4221	oxidoreductase activity
D3093_21230	COG1609	Transcriptional regulator
D3093_21260	COG1966	Carbon starvation protein
D3093_21265	COG2879	small protein
D3093_21280	COG4221	oxidoreductase activity
D3093_21300	COG0765	amino acid transport
D3093_21305	COG0765	amino acid transport
D3093_21340	COG0840	transmembrane signaling receptor activity
D3093_21345	COG2423	ornithine cyclodeaminase activity
D3093_21350	COG0657	acetylesterase activity
D3093_21380	COG2814	Major facilitator Superfamily
D3093_21385	COG0583	DNA-binding transcription factor activity
D3093_21390	COG0747	negative chemotaxis
D3093_21395	COG0601	transmembrane transport
D3093_21435	COG4520	surface antigen
D3093_21480	COG2900	Belongs to the SlyX family
D3093_21500	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3093_21505	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3093_21510	COG2080	2 iron, 2 sulfur cluster binding
D3093_21515	COG0583	DNA-binding transcription factor activity
D3093_21530	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D3093_21535	COG2301	Belongs to the HpcH HpaI aldolase family
D3093_21540	COG1960	acyl-CoA dehydrogenase activity
D3093_21580	COG0438	transferase activity, transferring glycosyl groups
D3093_21615	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3093_21620	COG0741	lytic transglycosylase activity
D3093_21625	COG1573	uracil-dna glycosylase
D3093_21650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_21675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3093_21680	COG1959	2 iron, 2 sulfur cluster binding
D3093_21690	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D3093_21700	COG4208	sulfate ABC transporter
D3093_21725	COG0745	RESPONSE REGULATOR receiver
D3093_21750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D3093_21755	COG0367	asparagine synthase
D3093_21760	COG0318	PFAM AMP-dependent synthetase and ligase
D3093_21780	COG0438	transferase activity, transferring glycosyl groups
D3093_21790	COG1215	transferase activity, transferring glycosyl groups
D3093_21810	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3093_21820	COG3693	PFAM glycoside hydrolase, family 10
D3093_21830	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D3093_21840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3093_21845	COG0588	phosphoglycerate mutase activity
D3093_21870	COG5002	protein histidine kinase activity
D3093_21880	COG4520	surface antigen
D3093_21895	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D3093_21905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3093_21920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D3093_21930	COG1530	ribonuclease E activity
D3093_21935	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D3093_21965	COG1192	Involved in chromosome partitioning
D3093_21970	COG1522	sequence-specific DNA binding
D3093_21980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3093_22000	COG1309	transcriptional regulator
D3093_22015	COG5507	3-demethylubiquinone-9 3-methyltransferase
D3093_22025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3093_22035	COG1396	sequence-specific DNA binding
D3093_22035	COG1917	Cupin 2, conserved barrel domain protein
D3093_22045	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3093_22050	COG2182	Extracellular solute-binding protein
D3093_22055	COG3842	ATPase activity
D3093_22060	COG0583	DNA-binding transcription factor activity
D3093_22070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3093_22100	COG3273	potassium ion transport
D3093_22100	COG0471	metal ion transport
D3093_22110	COG2814	Major facilitator Superfamily
D3093_22115	COG0583	DNA-binding transcription factor activity
D3093_22125	COG1566	PFAM secretion protein HlyD family protein
D3093_22170	COG4520	surface antigen
D3093_22175	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3093_22190	COG0789	Transcriptional regulator
D3093_22195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3093_22205	COG2860	membrane
D3093_22210	COG1741	Belongs to the pirin family
D3093_22235	COG2217	Heavy metal translocating P-type atpase
D3093_22270	COG1657	PFAM Prenyltransferase squalene oxidase
D3093_22290	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D3093_22305	COG2205	protein histidine kinase activity
D3093_22315	COG1253	flavin adenine dinucleotide binding
D3093_22320	COG0772	Belongs to the SEDS family
D3093_22340	COG0019	diaminopimelate decarboxylase activity
D3093_22355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3093_22365	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3093_22375	COG2086	electron transfer activity
D3093_22390	COG2723	6-phospho-beta-galactosidase activity
D3093_22450	COG1137	ATPase activity
D3093_22455	COG0840	transmembrane signaling receptor activity
D3093_22460	COG0795	lipopolysaccharide-transporting ATPase activity
D3093_22485	COG1749	Flagellar hook protein flgE
D3093_22485	COG1749	Flagellar hook protein flgE
D3093_22510	COG0737	Belongs to the 5'-nucleotidase family
D3093_22515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3093_22520	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3093_22525	COG1309	transcriptional regulator
D3093_22530	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_22535	COG0778	Nitroreductase
D3093_22540	COG1797	cobyrinic acid a,c-diamide synthase activity
D3093_22570	COG2099	Precorrin-6x reductase
D3093_22620	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3093_22630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3093_22635	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_22640	COG0625	glutathione transferase activity
D3093_22665	COG1640	4-alpha-glucanotransferase
D3093_22685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3093_22700	COG0745	RESPONSE REGULATOR receiver
D3093_22705	COG0784	Response regulator, receiver
D3093_22705	COG2198	Histidine kinase
D3093_22705	COG2205	protein histidine kinase activity
D3093_22710	COG1278	Cold shock
D3093_22720	COG1846	Transcriptional regulator
D3093_22725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3093_22730	COG0556	nucleotide-excision repair
D3093_22815	COG0438	transferase activity, transferring glycosyl groups
D3093_22830	COG0583	DNA-binding transcription factor activity
D3093_22835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3093_22850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3093_22855	COG4172	Belongs to the ABC transporter superfamily
D3093_22875	COG0028	Belongs to the TPP enzyme family
D3093_22880	COG3246	L-lysine catabolic process to acetate
D3093_22895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3093_22900	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3093_22910	COG1850	ribulose-bisphosphate carboxylase activity
D3093_22920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_22925	COG2204	response regulator
D3093_22950	COG0670	Belongs to the BI1 family
D3093_22970	COG4459	periplasmic nitrate reductase
D3093_22975	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3093_22995	COG3005	denitrification pathway
D3093_23025	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D3093_23030	COG1845	cytochrome c oxidase, subunit III
D3093_23035	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3093_23040	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3093_23045	COG0477	Major facilitator Superfamily
D3093_23060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3093_23090	COG0392	lysyltransferase activity
D3093_23095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3093_23125	COG0583	DNA-binding transcription factor activity
D3093_23130	COG0375	protein maturation
D3093_23135	COG3383	formate dehydrogenase (NAD+) activity
D3093_23140	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3093_23145	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3093_23150	COG0651	ATP synthesis coupled electron transport
D3093_23155	COG0650	Formate hydrogenlyase subunit 4
D3093_23160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3093_23165	COG4237	Hydrogenase 4 membrane
D3093_23170	COG0651	ATP synthesis coupled electron transport
D3093_23175	COG3261	NADH dehydrogenase
D3093_23175	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
D3093_23180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3093_23185	COG3260	NADH ubiquinone oxidoreductase 20
D3093_23195	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D3093_23200	COG2116	formate transmembrane transporter activity
D3093_23205	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3093_23210	COG0375	protein maturation
D3093_23245	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3093_23265	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3093_23270	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3093_23290	COG1846	Transcriptional regulator
D3093_23295	COG1764	response to oxidative stress
D3093_23320	COG2113	Glycine betaine
D3093_23325	COG4176	ABC-type proline glycine betaine transport system permease component
D3093_23330	COG4175	Glycine betaine
D3093_23335	COG0339	signal peptide processing
D3093_23365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3093_23370	COG0765	amino acid transport
D3093_23420	COG0840	transmembrane signaling receptor activity
D3093_23425	COG4178	(ABC) transporter
D3093_23435	COG1475	DNA binding
D3093_23440	COG1192	Involved in chromosome partitioning
D3093_23445	COG4783	chaperone-mediated protein folding
D3093_23465	COG3622	Belongs to the hyi family
D3093_23475	COG1215	transferase activity, transferring glycosyl groups
D3093_23490	COG3307	-O-antigen
D3093_23495	COG0489	protein tyrosine kinase activity
D3093_23495	COG3206	protein involved in exopolysaccharide biosynthesis
D3093_23525	COG1216	Glycosyl transferase, family 2
D3093_23595	COG0640	Transcriptional regulator
D3093_23600	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3093_23625	COG4566	intracellular signal transduction
D3093_23640	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_23650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3093_23660	COG1994	Peptidase M50
D3093_23660	COG0517	IMP dehydrogenase activity
D3093_23675	COG1522	sequence-specific DNA binding
D3093_23680	COG0583	DNA-binding transcription factor activity
D3093_23685	COG2271	Major facilitator Superfamily
D3093_23690	COG1802	Transcriptional regulator
D3093_23695	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3093_23705	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3093_23705	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3093_23710	COG2354	Protein conserved in bacteria
D3093_23730	COG1418	mRNA catabolic process
D3093_23735	COG1131	(ABC) transporter
D3093_23740	COG0842	Transport permease protein
D3093_23745	COG3791	Glutathione-dependent formaldehyde-activating
D3093_23750	COG0154	amidase activity
D3093_23755	COG0154	amidase activity
D3093_23760	COG1335	isochorismatase
D3093_23765	COG0747	negative chemotaxis
D3093_23770	COG0601	transmembrane transport
D3093_23775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3093_23785	COG4608	Belongs to the ABC transporter superfamily
D3093_23790	COG1335	isochorismatase
D3093_23795	COG3180	Ammonia monooxygenase
D3093_23800	COG1802	Transcriptional regulator
D3093_23810	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D3093_23815	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D3093_23820	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D3093_23825	COG2205	protein histidine kinase activity
D3093_23835	COG0861	Integral membrane protein TerC family
D3093_23845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_23850	COG2353	YceI-like domain
D3093_23865	COG4566	intracellular signal transduction
D3093_23870	COG4566	intracellular signal transduction
D3093_23875	COG4191	Histidine kinase
D3093_23895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3093_23910	COG0427	acetyl-CoA hydrolase
D3093_23925	COG0318	PFAM AMP-dependent synthetase and ligase
D3093_23930	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3093_23935	COG3842	ATPase activity
D3093_23945	COG1024	Enoyl-CoA hydratase
D3093_24055	COG0583	DNA-binding transcription factor activity
D3093_24065	COG3800	Transcriptional regulator
D3093_24065	COG1396	sequence-specific DNA binding
D3093_24075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3093_24095	COG2828	Protein conserved in bacteria
D3093_24115	COG2223	nitrite transmembrane transporter activity
D3093_24165	COG0489	protein tyrosine kinase activity
D3093_24175	COG4964	Belongs to the GSP D family
D3093_24205	COG3547	Transposase (IS116 IS110 IS902 family)
D3093_24215	COG0784	Response regulator, receiver
D3093_24215	COG2205	protein histidine kinase activity
D3093_24220	COG3609	addiction module antidote protein, CC2985 family
D3093_24225	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3093_24230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3093_24245	COG0784	Response regulator, receiver
D3093_24245	COG4191	Histidine kinase
D3093_24250	COG1454	alcohol dehydrogenase
D3093_24255	COG1012	belongs to the aldehyde dehydrogenase family
D3093_24290	COG0583	DNA-binding transcription factor activity
D3093_24315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3093_24320	COG1414	Transcriptional regulator
D3093_24325	COG2376	Dihydroxyacetone kinase
D3093_24340	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3093_24350	COG2610	gluconate transmembrane transporter activity
D3093_24370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3093_24375	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3093_24380	COG3842	ATPase activity
D3093_24390	COG0277	FAD linked oxidase domain protein
D3093_24405	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3093_24410	COG0459	protein refolding
D3093_24420	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3093_24425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_24430	COG1396	sequence-specific DNA binding
D3093_24435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3093_24440	COG0022	dehydrogenase e1 component
D3093_24445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3093_24455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3093_24455	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3093_24460	COG2175	clavaminate synthase activity
D3093_24470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3093_24475	COG1116	anion transmembrane transporter activity
D3093_24480	COG2175	clavaminate synthase activity
D3093_24500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3093_24505	COG3181	Tripartite tricarboxylate transporter family receptor
D3093_24515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3093_24520	COG4948	Mandelate Racemase Muconate Lactonizing
D3093_24530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3093_24535	COG0444	Belongs to the ABC transporter superfamily
D3093_24540	COG4608	Belongs to the ABC transporter superfamily
D3093_24550	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3093_24555	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3093_24560	COG0747	negative chemotaxis
D3093_24570	COG0601	transmembrane transport
D3093_24575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3093_24580	COG0444	Belongs to the ABC transporter superfamily
D3093_24585	COG4608	Belongs to the ABC transporter superfamily
D3093_24590	COG0697	spore germination
D3093_24595	COG1982	Orn Lys Arg decarboxylase major
D3093_24605	COG1335	isochorismatase
D3093_24615	COG1396	sequence-specific DNA binding
D3093_24615	COG1917	Cupin 2, conserved barrel domain protein
D3093_24620	COG0318	PFAM AMP-dependent synthetase and ligase
D3093_24640	COG1012	belongs to the aldehyde dehydrogenase family
D3093_24645	COG1024	Enoyl-CoA hydratase
D3093_24650	COG2186	Transcriptional regulator
D3093_24660	COG2382	esterase
D3093_24665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3093_24675	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_24680	COG1535	isochorismatase
D3093_24680	COG3433	isochorismatase activity
D3093_24685	COG1021	2,3-dihydroxybenzoate-AMP ligase
D3093_24690	COG1169	isochorismate synthase
D3093_24710	COG4771	TonB-dependent receptor
D3093_24765	COG1253	flavin adenine dinucleotide binding
D3093_24795	COG0586	Pfam SNARE associated Golgi protein
D3093_24815	COG1802	Transcriptional regulator
D3093_24820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3093_24825	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3093_24830	COG4948	Mandelate Racemase Muconate Lactonizing
D3093_24835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3093_24860	COG1126	abc transporter atp-binding protein
D3093_24880	COG3547	Transposase (IS116 IS110 IS902 family)
D3093_24890	COG3547	Transposase (IS116 IS110 IS902 family)
D3093_24895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3093_24945	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
D3093_24955	COG0189	ligase activity
D3093_24960	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
D3093_24970	COG0702	epimerase
D3093_24980	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3093_24990	COG1229	Formylmethanofuran dehydrogenase subunit A
D3093_24995	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
D3093_25015	COG1131	(ABC) transporter
D3093_25075	COG2010	Cytochrome c
D3093_25100	COG1573	uracil-dna glycosylase
D3093_25120	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D3093_25135	COG0583	DNA-binding transcription factor activity
D3093_25160	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_25175	COG3842	ATPase activity
D3093_25205	COG1764	response to oxidative stress
D3093_25210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3093_25215	COG1960	acyl-CoA dehydrogenase activity
D3093_25220	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3093_25290	COG0668	transmembrane transport
D3093_25330	COG1139	Iron-sulfur cluster binding protein
D3093_25335	COG0247	lactate metabolic process
D3093_25340	COG0277	FAD linked oxidase domain protein
D3093_25345	COG1620	l-lactate permease
D3093_25350	COG2186	Transcriptional regulator
D3093_25360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3093_25365	COG0542	response to heat
D3093_25370	COG1414	Transcriptional regulator
D3093_25375	COG3734	2-keto-3-deoxy-galactonokinase
D3093_25380	COG0800	Aldolase
D3093_25405	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_25430	COG5002	protein histidine kinase activity
D3093_25430	COG2205	protein histidine kinase activity
D3093_25430	COG0784	Response regulator, receiver
D3093_25440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3093_25480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3093_25485	COG4191	Histidine kinase
D3093_25490	COG4566	intracellular signal transduction
D3093_25500	COG0848	biopolymer transport protein
D3093_25545	COG3275	phosphorelay sensor kinase activity
D3093_25555	COG1966	Carbon starvation protein
D3093_25565	COG1363	Peptidase, m42
D3093_25570	COG0189	ligase activity
D3093_25570	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3093_25570	COG2918	glutathione biosynthetic process
D3093_25575	COG0367	asparagine synthase
D3093_25615	COG1802	Transcriptional regulator
D3093_25620	COG0517	IMP dehydrogenase activity
D3093_25620	COG0617	tRNA 3'-terminal CCA addition
D3093_25620	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D3093_25630	COG0861	Integral membrane protein TerC family
D3093_25700	COG2226	methyltransferase
D3093_25720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3093_25735	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D3093_25740	COG1846	Transcriptional regulator
D3093_25750	COG1309	transcriptional regulator
D3093_25755	COG0318	PFAM AMP-dependent synthetase and ligase
D3093_25760	COG2186	Transcriptional regulator
D3093_25765	COG1960	acyl-CoA dehydrogenase activity
D3093_25775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3093_25810	COG0318	PFAM AMP-dependent synthetase and ligase
D3093_25820	COG1960	acyl-CoA dehydrogenase activity
D3093_25825	COG0183	Belongs to the thiolase family
D3093_25830	COG1960	acyl-CoA dehydrogenase activity
D3093_25835	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3093_25840	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D3093_25845	COG4770	biotin carboxylase activity
D3093_25910	COG2723	6-phospho-beta-galactosidase activity
D3093_25920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3093_25930	COG4178	(ABC) transporter
D3093_25940	COG1216	Glycosyl transferase, family 2
D3093_25940	COG1442	glycosyl transferase family 8
D3093_25985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3093_26000	COG2197	response regulator
D3093_26010	COG2198	Histidine kinase
D3093_26010	COG0643	Histidine kinase
D3093_26020	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3093_26030	COG2201	protein-glutamate methylesterase activity
D3093_26035	COG0835	chemotaxis
D3093_26055	COG2095	MarC family integral membrane protein
D3093_26080	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_26085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3093_26100	COG0395	ABC-type sugar transport system, permease component
D3093_26110	COG3842	ATPase activity
D3093_26125	COG0586	Pfam SNARE associated Golgi protein
D3093_26145	COG4615	Cyclic peptide transporter
D3093_26175	COG0840	transmembrane signaling receptor activity
D3093_26180	COG0840	transmembrane signaling receptor activity
D3093_26180	COG3290	protein histidine kinase activity
D3093_26215	COG5002	protein histidine kinase activity
D3093_26215	COG0784	Response regulator, receiver
D3093_26220	COG0784	Response regulator, receiver
D3093_26220	COG4191	Histidine kinase
D3093_26235	COG2388	GCN5-related N-acetyl-transferase
D3093_26240	COG0366	Alpha amylase catalytic
D3093_26245	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_26270	COG0840	transmembrane signaling receptor activity
D3093_26270	COG3290	protein histidine kinase activity
D3093_26275	COG1971	Probably functions as a manganese efflux pump
D3093_26305	COG4122	O-methyltransferase activity
D3093_26320	COG1473	amidohydrolase
D3093_26325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3093_26365	COG0840	transmembrane signaling receptor activity
D3093_26365	COG0840	transmembrane signaling receptor activity
D3093_26390	COG3842	ATPase activity
D3093_26405	COG1653	transport
D3093_26450	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D3093_26460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3093_26480	COG0243	molybdopterin cofactor binding
D3093_26505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3093_26510	COG1116	anion transmembrane transporter activity
D3093_26515	COG0402	S-adenosylhomocysteine deaminase activity
D3093_26530	COG0154	amidase activity
D3093_26555	COG3842	ATPase activity
D3093_26565	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3093_26575	COG2351	hydroxyisourate hydrolase activity
D3093_26585	COG0154	amidase activity
D3093_26590	COG5002	protein histidine kinase activity
D3093_26590	COG0784	Response regulator, receiver
D3093_26635	COG3387	PFAM Glycoside hydrolase 15-related
D3093_26645	COG2197	response regulator
D3093_26650	COG2197	response regulator
D3093_26655	COG2197	response regulator
D3093_26665	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3093_26670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3093_26675	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3093_26680	COG0438	transferase activity, transferring glycosyl groups
D3093_26700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3093_26720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3093_26840	COG4383	Mu-like prophage protein gp29
D3093_26860	COG4397	Mu-like prophage major head subunit gpT
D3093_26940	COG0148	phosphopyruvate hydratase activity
D3093_26950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3093_26960	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_26965	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D3093_26970	COG1802	Transcriptional regulator
D3093_26990	COG0668	transmembrane transport
D3093_27065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3093_27065	COG2226	methyltransferase
D3093_27065	COG0596	Alpha beta hydrolase
D3093_27070	COG0183	Belongs to the thiolase family
D3093_27075	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_27085	COG2814	Major facilitator Superfamily
D3093_27090	COG0583	DNA-binding transcription factor activity
D3093_27100	COG5001	Diguanylate cyclase
D3093_27100	COG3300	MHYT domain
D3093_27105	COG0012	GTP binding
D3093_27125	COG2205	protein histidine kinase activity
D3093_27125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3093_27130	COG2201	protein-glutamate methylesterase activity
D3093_27135	COG2201	protein-glutamate methylesterase activity
D3093_27145	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3093_27145	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3093_27165	COG4251	negative regulation of phosphorylation
D3093_27170	COG0745	RESPONSE REGULATOR receiver
D3093_27175	COG0745	RESPONSE REGULATOR receiver
D3093_27195	COG1131	(ABC) transporter
D3093_27220	COG2011	ABC-type metal ion transport system permease component
D3093_27225	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D3093_27230	COG0318	PFAM AMP-dependent synthetase and ligase
D3093_27250	COG2010	Cytochrome c
D3093_27250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3093_27255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3093_27270	COG1254	Belongs to the acylphosphatase family
D3093_27295	COG2239	Acts as a magnesium transporter
D3093_27300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3093_27300	COG2022	thiamine diphosphate biosynthetic process
D3093_27310	COG2022	thiamine diphosphate biosynthetic process
D3093_27365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3093_27370	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D3093_27380	COG0191	fructose-bisphosphate aldolase activity
D3093_27395	COG0348	domain, Protein
D3093_27410	COG4251	negative regulation of phosphorylation
D3093_27415	COG0784	Response regulator, receiver
D3093_27460	COG1595	DNA-templated transcription, initiation
D3093_27465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3093_27470	COG1045	serine acetyltransferase
D3093_27495	COG3842	ATPase activity
D3093_27500	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3093_27505	COG1178	ABC-type Fe3 transport system permease component
D3093_27515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3093_27520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3093_27525	COG2233	PERMEase
D3093_27535	COG0747	negative chemotaxis
D3093_27540	COG0601	transmembrane transport
D3093_27555	COG4608	Belongs to the ABC transporter superfamily
D3093_27560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3093_27580	COG1744	ABC transporter substrate-binding protein PnrA-like
D3093_27615	COG0484	heat shock protein binding
D3093_27625	COG0564	pseudouridine synthase activity
D3093_27640	COG0156	8-amino-7-oxononanoate synthase activity
D3093_27650	COG4106	trans-aconitate 2-methyltransferase activity
D3093_27650	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3093_27655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3093_27660	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D3093_27670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3093_27670	COG0574	Belongs to the PEP-utilizing enzyme family
D3093_27685	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D3093_27690	COG1278	Cold shock
D3093_27695	COG0318	PFAM AMP-dependent synthetase and ligase
D3093_27715	COG1496	oxidoreductase activity
D3093_27725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3093_27730	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D3093_27740	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3093_27745	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3093_27750	COG1129	ABC transporter
D3093_27755	COG1879	ABC-type sugar transport system periplasmic component
D3093_27790	COG4214	carbohydrate transport
D3093_27800	COG0129	dihydroxy-acid dehydratase activity
D3093_27815	COG0246	Mannitol dehydrogenase
D3093_27820	COG0725	ABC transporter, periplasmic molybdate-binding protein
D3093_27835	COG5039	Polysaccharide pyruvyl transferase
D3093_27840	COG2132	Multicopper oxidase
D3093_27850	COG1309	transcriptional regulator
D3093_27855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3093_27860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3093_27865	COG0702	epimerase
D3093_27870	COG1733	regulation of RNA biosynthetic process
D3093_27880	COG0583	DNA-binding transcription factor activity
D3093_27895	COG2133	pyrroloquinoline quinone binding
D3093_27930	COG1312	Catalyzes the dehydration of D-mannonate
D3093_27935	COG0246	Mannitol dehydrogenase
D3093_27945	COG1802	Transcriptional regulator
D3093_27950	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_27955	COG1917	Cupin 2, conserved barrel domain protein
D3093_27960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3093_27970	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3093_27975	COG0667	Aldo Keto reductase
D3093_27980	COG1802	Transcriptional regulator
D3093_27985	COG1803	Methylglyoxal synthase
D3093_27990	COG1904	glucuronate isomerase
D3093_27995	COG2721	sulfolactate sulfo-lyase activity
D3093_28030	COG0861	Integral membrane protein TerC family
D3093_28070	COG4166	transmembrane transport
D3093_28080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3093_28085	COG0798	PFAM Bile acid sodium symporter
D3093_28100	COG2188	Transcriptional regulator
D3093_28115	COG0154	amidase activity
D3093_28130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3093_28135	COG1960	acyl-CoA dehydrogenase activity
D3093_28140	COG2079	MmgE PrpD family protein
D3093_28160	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3093_28165	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_28180	COG1595	DNA-templated transcription, initiation
D3093_28210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3093_28255	COG1132	(ABC) transporter
D3093_28260	COG0784	Response regulator, receiver
D3093_28260	COG4191	Histidine kinase
D3093_28270	COG2199	diguanylate cyclase activity
D3093_28270	COG2203	Gaf domain
D3093_28290	COG0405	Gamma-glutamyltransferase
D3093_28320	COG1858	cytochrome C peroxidase
D3093_28345	COG4964	Belongs to the GSP D family
D3093_28475	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3093_28500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3093_28510	COG3845	ABC transporter
D3093_28520	COG4603	Belongs to the binding-protein-dependent transport system permease family
D3093_28525	COG1079	Belongs to the binding-protein-dependent transport system permease family
D3093_28530	COG0402	S-adenosylhomocysteine deaminase activity
D3093_28535	COG0840	transmembrane signaling receptor activity
D3093_28545	COG4191	Histidine kinase
D3093_28570	COG1414	Transcriptional regulator
D3093_28575	COG3383	formate dehydrogenase (NAD+) activity
D3093_28595	COG1803	Methylglyoxal synthase
D3093_28595	COG1597	lipid kinase activity
D3093_28605	COG0628	permease
D3093_28610	COG3416	Protein conserved in bacteria
D3093_28655	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3093_28665	COG1338	Plays a role in the flagellum-specific transport system
D3093_28670	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3093_28680	COG1766	The M ring may be actively involved in energy transduction
D3093_28715	COG3005	denitrification pathway
D3093_28725	COG0243	molybdopterin cofactor binding
D3093_28745	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D3093_28750	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
D3093_28755	COG4786	Flagellar basal body rod
D3093_28760	COG4786	Flagellar basal body rod
D3093_28770	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3093_28775	COG1360	Flagellar Motor Protein
D3093_28845	COG2204	response regulator
D3093_28850	COG1454	alcohol dehydrogenase
D3093_28850	COG1012	belongs to the aldehyde dehydrogenase family
D3093_28865	COG0588	phosphoglycerate mutase activity
D3093_28875	COG3842	ATPase activity
D3093_28890	COG2985	domain, Protein
D3093_28900	COG2204	response regulator
D3093_28905	COG4191	Histidine kinase
D3093_28915	COG3300	MHYT domain
D3093_28915	COG5001	Diguanylate cyclase
D3093_28940	COG1522	sequence-specific DNA binding
D3093_28950	COG0028	Belongs to the TPP enzyme family
D3093_28960	COG4191	Histidine kinase
D3093_28970	COG5487	UPF0391 membrane protein
D3093_28975	COG0793	Belongs to the peptidase S41A family
D3093_28980	COG0583	DNA-binding transcription factor activity
D3093_28985	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_28995	COG0583	DNA-binding transcription factor activity
D3093_29000	COG0028	Belongs to the TPP enzyme family
D3093_29005	COG1012	belongs to the aldehyde dehydrogenase family
D3093_29030	COG0784	Response regulator, receiver
D3093_29030	COG4191	Histidine kinase
D3093_29035	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D3093_29065	COG0583	DNA-binding transcription factor activity
D3093_29070	COG2855	membrane
D3093_29085	COG0546	phosphoglycolate phosphatase activity
D3093_29105	COG1192	Involved in chromosome partitioning
D3093_29110	COG1475	DNA binding
D3093_29120	COG0028	Belongs to the TPP enzyme family
D3093_29135	COG0437	4 iron, 4 sulfur cluster binding
D3093_29145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D3093_29155	COG1012	belongs to the aldehyde dehydrogenase family
D3093_29175	COG0280	phosphate acetyltransferase
D3093_29180	COG1414	Transcriptional regulator
D3093_29185	COG1414	Transcriptional regulator
D3093_29195	COG1522	sequence-specific DNA binding
D3093_29200	COG0251	oxidation-reduction process
D3093_29205	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3093_29250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3093_29265	COG0583	DNA-binding transcription factor activity
D3093_29295	COG2197	response regulator
D3093_29300	COG3920	Histidine kinase
D3093_29310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3093_29310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3093_29315	COG1105	Belongs to the carbohydrate kinase PfkB family
D3093_29320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3093_29320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3093_29325	COG1609	Transcriptional regulator
D3093_29335	COG1335	isochorismatase
D3093_29340	COG2309	aminopeptidase activity
D3093_29345	COG0596	Alpha beta hydrolase
D3093_29350	COG3473	Maleate cis-trans isomerase
D3093_29380	COG0683	leucine binding
D3093_29400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3093_29455	COG0154	amidase activity
D3093_29485	COG2204	response regulator
D3093_29485	COG5564	TIM-barrel signal transduction protein
D3093_29490	COG5441	Belongs to the UPF0261 family
D3093_29495	COG5564	TIM-barrel signal transduction protein
D3093_29510	COG2086	electron transfer activity
D3093_29515	COG0277	FAD linked oxidase domain protein
D3093_29530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3093_29545	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3093_29550	COG0567	Dehydrogenase, E1 component
D3093_29570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3093_29575	COG1845	cytochrome c oxidase, subunit III
D3093_29585	COG2186	Transcriptional regulator
D3093_29590	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3093_29595	COG2267	carboxylic ester hydrolase activity
D3093_29640	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D3093_29650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3093_29655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3093_29660	COG1120	ATPase activity
D3093_29665	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D3093_29670	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3093_29685	COG1802	Transcriptional regulator
D3093_29690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3093_29710	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3093_29720	COG5443	negative regulation of bacterial-type flagellum assembly
D3093_29740	COG2814	Major facilitator Superfamily
D3093_29760	COG1815	bacterial-type flagellum-dependent cell motility
D3093_29765	COG1558	bacterial-type flagellum-dependent cell motility
D3093_29770	COG1677	Flagellar hook-basal body complex protein FliE
D3093_29775	COG4794	Type iii secretion
D3093_29785	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3093_29790	COG1684	flagellar biosynthetic protein fliR
D3093_29795	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3093_29825	COG1706	bacterial-type flagellum-dependent cell motility
D3093_29840	COG1749	Flagellar hook protein flgE
D3093_29870	COG0861	Integral membrane protein TerC family
D3093_29875	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3093_29885	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3093_29895	COG1802	Transcriptional regulator
D3093_29900	COG0697	spore germination
D3093_29905	COG2116	formate transmembrane transporter activity
D3093_29910	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3093_29915	COG0469	pyruvate kinase activity
D3093_29920	COG4251	negative regulation of phosphorylation
D3093_29925	COG5002	protein histidine kinase activity
D3093_29930	COG1309	transcriptional regulator
D3093_29935	COG1309	transcriptional regulator
D3093_29940	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3093_29945	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3093_29950	COG0837	glucose binding
D3093_29950	COG1737	Transcriptional regulator
D3093_29955	COG1882	Formate acetyltransferase
D3093_29985	COG2842	Transposition protein
D3093_30105	COG4383	Mu-like prophage protein gp29
D3093_30130	COG1192	Involved in chromosome partitioning
D3093_30140	COG1802	Transcriptional regulator
D3093_30140	COG4626	Terminase
D3093_30175	COG4774	siderophore transport
D3093_30185	COG1595	DNA-templated transcription, initiation
D3093_30205	COG0765	amino acid transport
D3093_30215	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3093_30225	COG1126	abc transporter atp-binding protein
D3093_30240	COG2115	Belongs to the xylose isomerase family
D3093_30245	COG0673	inositol 2-dehydrogenase activity
D3093_30255	COG1879	ABC-type sugar transport system periplasmic component
D3093_30260	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3093_30270	COG1940	carbohydrate kinase activity
D3093_30280	COG0631	protein serine/threonine phosphatase activity
D3093_30370	COG0631	protein serine/threonine phosphatase activity
D3093_30410	COG1121	(ABC) transporter
D3093_30425	COG1136	(ABC) transporter
D3093_30425	COG0577	efflux transmembrane transporter activity
D3093_30430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3093_30445	COG1595	DNA-templated transcription, initiation
D3093_30460	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_30485	COG1053	succinate dehydrogenase
D3093_30505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3093_30510	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D3093_30520	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_30530	COG2301	Belongs to the HpcH HpaI aldolase family
D3093_30535	COG2072	flavoprotein involved in K transport
D3093_30555	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D3093_30555	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3093_30565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3093_30615	COG4774	siderophore transport
D3093_30620	COG1120	ATPase activity
D3093_30630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3093_30635	COG1132	(ABC) transporter
D3093_30665	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3093_30670	COG0402	S-adenosylhomocysteine deaminase activity
D3093_30685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3093_30695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3093_30705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3093_30710	COG0842	Transport permease protein
D3093_30710	COG1129	ABC transporter
D3093_30715	COG0842	Transport permease protein
D3093_30725	COG3721	Heme iron utilization protein
D3093_30735	COG0745	RESPONSE REGULATOR receiver
D3093_30740	COG1120	ATPase activity
D3093_30745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3093_30755	COG3720	iron ion transport
D3093_30765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3093_30790	COG0583	DNA-binding transcription factor activity
D3093_30800	COG1017	nitric oxide dioxygenase activity
D3093_30800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3093_30805	COG0625	glutathione transferase activity
D3093_30810	COG1802	Transcriptional regulator
D3093_30820	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3093_30840	COG2197	response regulator
D3093_30850	COG0625	glutathione transferase activity
D3093_30865	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_30895	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_30900	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3093_30905	COG1053	succinate dehydrogenase
D3093_30915	COG0673	inositol 2-dehydrogenase activity
D3093_30935	COG0431	NADPH-dependent FMN reductase
D3093_30935	COG3976	FMN-binding domain protein
D3093_30935	COG1053	succinate dehydrogenase
D3093_30940	COG1902	pentaerythritol trinitrate reductase activity
D3093_30945	COG1053	succinate dehydrogenase
D3093_30955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3093_30965	COG0765	amino acid transport
D3093_30970	COG1126	abc transporter atp-binding protein
D3093_30975	COG1012	belongs to the aldehyde dehydrogenase family
D3093_30980	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3093_30985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D3093_30995	COG2721	sulfolactate sulfo-lyase activity
D3093_31020	COG0745	RESPONSE REGULATOR receiver
D3093_31050	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3093_31055	COG1024	Enoyl-CoA hydratase
D3093_31060	COG0022	dehydrogenase e1 component
D3093_31060	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3093_31065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3093_31075	COG0683	leucine binding
D3093_31110	COG0183	Belongs to the thiolase family
D3093_31140	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3093_31240	COG3842	ATPase activity
D3093_31245	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3093_31250	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3093_31255	COG3938	Belongs to the proline racemase family
D3093_31260	COG1802	Transcriptional regulator
D3093_31265	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D3093_31270	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3093_31275	COG0066	3-isopropylmalate dehydratase activity
D3093_31290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3093_31350	COG3842	ATPase activity
D3093_31360	COG1349	DNA-binding transcription factor activity
D3093_31385	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_31400	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3093_31410	COG1024	Enoyl-CoA hydratase
D3093_31415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3093_31420	COG0154	amidase activity
D3093_31450	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3093_31455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3093_31460	COG0697	spore germination
D3093_31475	COG2188	Transcriptional regulator
D3093_31500	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D3093_31550	COG4772	TonB-dependent receptor
D3093_31575	COG3842	ATPase activity
D3093_31595	COG0318	PFAM AMP-dependent synthetase and ligase
D3093_31600	COG1024	Enoyl-CoA hydratase
D3093_31605	COG0604	alcohol dehydrogenase
D3093_31615	COG1414	Transcriptional regulator
D3093_31625	COG0601	transmembrane transport
D3093_31630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3093_31635	COG0444	Belongs to the ABC transporter superfamily
D3093_31640	COG4608	Belongs to the ABC transporter superfamily
D3093_31660	COG3250	beta-galactosidase activity
D3093_31665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3093_31670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3093_31670	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3093_31690	COG0861	Integral membrane protein TerC family
D3093_31695	COG0251	oxidation-reduction process
D3093_31705	COG0251	oxidation-reduction process
D3093_31710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3093_31730	COG1177	transmembrane transport
D3093_31735	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3093_31740	COG3842	ATPase activity
D3093_31755	COG1126	abc transporter atp-binding protein
D3093_31760	COG0765	amino acid transport
D3093_31770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3093_31780	COG0277	FAD linked oxidase domain protein
D3093_31785	COG1396	sequence-specific DNA binding
D3093_31815	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_31820	COG3246	L-lysine catabolic process to acetate
D3093_31825	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3093_31830	COG2204	response regulator
D3093_31850	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3093_31855	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3093_31865	COG4566	intracellular signal transduction
D3093_31865	COG0745	RESPONSE REGULATOR receiver
D3093_31880	COG0411	ABC transporter
D3093_31895	COG0683	leucine binding
D3093_31900	COG2814	Major facilitator Superfamily
D3093_31910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D3093_31915	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3093_31945	COG0633	Ferredoxin
D3093_31950	COG2124	cytochrome p450
D3093_31965	COG0583	DNA-binding transcription factor activity
D3093_31975	COG1595	DNA-templated transcription, initiation
D3093_31980	COG4774	siderophore transport
D3093_31995	COG4774	siderophore transport
D3093_32015	COG1120	ATPase activity
D3093_32035	COG2271	Major facilitator Superfamily
D3093_32040	COG0583	DNA-binding transcription factor activity
D3093_32070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_32085	COG0826	peptidase U32
D3093_32110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3093_32125	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D3093_32140	COG4263	nitrous-oxide reductase activity
D3093_32160	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3093_32180	COG1053	succinate dehydrogenase
D3093_32180	COG3976	FMN-binding domain protein
D3093_32180	COG0431	NADPH-dependent FMN reductase
D3093_32185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3093_32195	COG1012	belongs to the aldehyde dehydrogenase family
D3093_32210	COG0583	DNA-binding transcription factor activity
D3093_32220	COG2814	Major facilitator Superfamily
D3093_32230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3093_32235	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3093_32240	COG2080	2 iron, 2 sulfur cluster binding
D3093_32255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3093_32265	COG0714	Associated with various cellular activities
D3093_32300	COG3119	arylsulfatase activity
D3093_32325	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_32335	COG0604	alcohol dehydrogenase
D3093_32335	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_32335	COG3321	synthase
D3093_32405	COG2207	Transcriptional regulator
D3093_32420	COG1566	PFAM secretion protein HlyD family protein
D3093_32430	COG0765	amino acid transport
D3093_32435	COG4597	amino acid ABC transporter
D3093_32450	COG0251	oxidation-reduction process
D3093_32455	COG3608	succinylglutamate desuccinylase aspartoacylase
D3093_32460	COG1609	Transcriptional regulator
D3093_32480	COG3425	synthase
D3093_32495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3093_32495	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_32495	COG3321	synthase
D3093_32495	COG4221	oxidoreductase activity
D3093_32500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3093_32500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3093_32500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3093_32500	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_32500	COG3321	synthase
D3093_32505	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3093_32505	COG4221	oxidoreductase activity
D3093_32505	COG3321	synthase
D3093_32505	COG0300	oxidoreductase activity
D3093_32510	COG2072	flavoprotein involved in K transport
D3093_32515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3093_32525	COG1024	Enoyl-CoA hydratase
D3093_32530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3093_32540	COG0300	oxidoreductase activity
D3093_32540	COG4221	oxidoreductase activity
D3093_32540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3093_32540	COG3321	synthase
D3093_32545	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_32545	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3093_32545	COG4221	oxidoreductase activity
D3093_32545	COG3321	synthase
D3093_32550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3093_32550	COG3321	synthase
D3093_32550	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_32550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3093_32550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3093_32570	COG4521	taurine ABC transporter
D3093_32575	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3093_32580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3093_32585	COG3119	arylsulfatase activity
D3093_32590	COG2175	clavaminate synthase activity
D3093_32600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3093_32605	COG1116	anion transmembrane transporter activity
D3093_32625	COG0714	Associated with various cellular activities
D3093_32630	COG3256	nitric oxide reductase
D3093_32680	COG0534	Mate efflux family protein
D3093_32705	COG3344	reverse transcriptase
D3093_32715	COG3328	transposase activity
D3093_32745	COG0210	DNA helicase
D3093_32750	COG1192	Involved in chromosome partitioning
D3093_32755	COG1475	DNA binding
D3093_32760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3093_32805	COG4974	Belongs to the 'phage' integrase family
D3093_32815	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3093_32825	COG2086	electron transfer activity
D3093_32830	COG0840	transmembrane signaling receptor activity
D3093_32855	COG1024	Enoyl-CoA hydratase
D3093_32860	COG1960	acyl-CoA dehydrogenase activity
D3093_32875	COG2084	Dehydrogenase
D3093_32885	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3093_32900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3093_32910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3093_32940	COG1028	Short-chain dehydrogenase reductase Sdr
D3093_32950	COG1881	PFAM PEBP family protein
D3093_32985	COG2205	protein histidine kinase activity
D3093_33015	COG2376	Dihydroxyacetone kinase
D3093_33025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3093_33030	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D3093_33050	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3093_33055	COG1879	ABC-type sugar transport system periplasmic component
D3093_33060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D3093_33075	COG4999	Histidine kinase
D3093_33075	COG3437	response regulator, receiver
D3093_33075	COG2205	protein histidine kinase activity
D3093_33075	COG3850	Histidine kinase
D3093_33095	COG1132	(ABC) transporter
D3093_33095	COG2375	cellular response to nickel ion
D3093_33100	COG1132	(ABC) transporter
D3093_33105	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3093_33110	COG4605	iron ion homeostasis
D3093_33115	COG4604	ABC transporter, ATP-binding protein
D3093_33120	COG4607	ABC-type enterochelin transport system periplasmic component
D3093_33125	COG4774	siderophore transport
D3093_33135	COG1404	Belongs to the peptidase S8 family
D3093_33265	COG0531	amino acid
D3093_33285	COG3485	protocatechuate 3,4-dioxygenase
D3093_33305	COG1518	maintenance of DNA repeat elements
D3093_33335	COG1203	CRISPR-associated helicase, Cas3
D3093_33405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3093_33475	COG0583	DNA-binding transcription factor activity
D3093_33490	COG1846	Transcriptional regulator
D3093_33550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3093_33700	COG1396	sequence-specific DNA binding
D3093_33745	COG3177	Filamentation induced by cAMP protein fic
D3093_33780	COG0551	DNA topoisomerase type I activity
D3093_33780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3093_33795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3093_33865	COG2963	transposase activity
D3093_33870	COG3549	Plasmid maintenance system killer
D3093_33985	COG3550	peptidyl-serine autophosphorylation
D3093_33995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3093_34000	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
D3093_34035	COG3451	type IV secretory pathway VirB4
D3093_34140	COG1509	lysine 2,3-aminomutase activity
D3093_34145	COG2175	clavaminate synthase activity
D3093_34165	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D3093_34195	COG0534	Mate efflux family protein
D3093_34240	COG3547	Transposase (IS116 IS110 IS902 family)
D3093_34260	COG0438	transferase activity, transferring glycosyl groups
D3093_34285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3093_34345	COG0438	transferase activity, transferring glycosyl groups
D3093_34350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3093_34370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3093_34375	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D3093_34390	COG0529	Catalyzes the synthesis of activated sulfate
D3093_34390	COG2895	sulfate adenylyltransferase (ATP) activity
D3093_34395	COG0175	sulfate reduction
D3093_34430	COG0500	methyltransferase
D3093_34440	COG1216	Glycosyl transferase, family 2
D3093_34440	COG0438	transferase activity, transferring glycosyl groups
D3093_34445	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D3093_34455	COG1091	dTDP-4-dehydrorhamnose reductase activity
D3093_34460	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D3093_34475	COG1216	Glycosyl transferase, family 2
D3093_34475	COG0438	transferase activity, transferring glycosyl groups
D3093_34520	COG2226	methyltransferase
D3093_34525	COG0528	UMP kinase activity
D3093_34530	COG0528	UMP kinase activity
D3093_34550	COG0494	nUDIX hydrolase
D3093_34565	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3093_34575	COG1086	Polysaccharide biosynthesis protein
D3093_34590	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3093_34600	COG1475	DNA binding
D3093_34605	COG1192	Involved in chromosome partitioning
D3093_34615	COG0579	oxidoreductase
D3093_34625	COG2274	protein secretion by the type I secretion system
D3093_34640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3093_34670	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3093_34700	COG0463	Glycosyl transferase, family 2
D3093_34700	COG1216	Glycosyl transferase, family 2
D3093_34705	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3093_34720	COG2089	acid synthase
D3093_34725	COG0367	asparagine synthase
D3093_34730	COG0438	transferase activity, transferring glycosyl groups
D3093_34855	COG3547	Transposase (IS116 IS110 IS902 family)
D3093_34875	COG0741	lytic transglycosylase activity
D3093_34915	COG3772	lysozyme
D3093_34985	COG0604	alcohol dehydrogenase
D3093_34990	COG1733	regulation of RNA biosynthetic process
D3093_35075	COG0328	RNA-DNA hybrid ribonuclease activity
D3093_35100	COG1396	sequence-specific DNA binding
D3093_35155	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D3093_35195	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3093_35285	COG0305	Participates in initiation and elongation during chromosome replication
D3093_35325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3093_35330	COG1518	maintenance of DNA repeat elements
D3093_35345	COG1857	crispr-associated protein
D3093_35360	COG1203	CRISPR-associated helicase, Cas3
D3093_35550	COG3328	transposase activity
D3093_35560	COG2226	methyltransferase
D3093_35580	COG1783	phage Terminase large subunit