locus-tag	class	description
D9623_00015	COG2835	tetraacyldisaccharide 4'-kinase activity
D9623_00020	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D9623_00025	COG3118	belongs to the thioredoxin family
D9623_00040	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9623_00055	COG0840	transmembrane signaling receptor activity
D9623_00065	COG2770	Histidine kinase
D9623_00065	COG3437	response regulator, receiver
D9623_00070	COG2902	Dehydrogenase
D9623_00075	COG2264	protein methyltransferase activity
D9623_00100	COG0138	bifunctional purine biosynthesis protein purh
D9623_00110	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D9623_00110	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D9623_00125	COG0501	Belongs to the peptidase M48B family
D9623_00130	COG5508	conserved small protein
D9623_00145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9623_00160	COG2350	Protein conserved in bacteria
D9623_00165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D9623_00180	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9623_00185	COG0181	hydroxymethylbilane synthase activity
D9623_00215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9623_00245	COG2885	chlorophyll binding
D9623_00255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9623_00265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_00265	COG4191	Histidine kinase
D9623_00270	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D9623_00290	COG5002	protein histidine kinase activity
D9623_00290	COG0784	Response regulator, receiver
D9623_00290	COG2205	protein histidine kinase activity
D9623_00305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_00325	COG0582	viral genome integration into host DNA
D9623_00410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D9623_00415	COG0443	Heat shock 70 kDa protein
D9623_00480	COG0514	ATP-dependent DNA helicase (RecQ)
D9623_00515	COG2967	ApaG domain
D9623_00520	COG0302	gtp cyclohydrolase
D9623_00530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D9623_00540	COG0302	gtp cyclohydrolase
D9623_00545	COG2205	protein histidine kinase activity
D9623_00560	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_00575	COG0285	dihydrofolate synthase activity
D9623_00580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D9623_00590	COG0133	tryptophan synthase activity
D9623_00595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_00605	COG2205	protein histidine kinase activity
D9623_00610	COG1252	NADH dehydrogenase
D9623_00620	COG0745	RESPONSE REGULATOR receiver
D9623_00640	COG0802	atpase or kinase
D9623_00650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D9623_00655	COG2887	Belongs to the helicase family. UvrD subfamily
D9623_00665	COG1074	ATP-dependent DNA helicase activity
D9623_00675	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9623_00680	COG4133	protoheme IX ABC transporter activity
D9623_00685	COG2985	domain, Protein
D9623_00730	COG1872	DUF167
D9623_00735	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D9623_00740	COG0598	Magnesium transport protein CorA
D9623_00760	COG1573	uracil-dna glycosylase
D9623_00765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D9623_00770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D9623_00780	COG0583	DNA-binding transcription factor activity
D9623_00785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D9623_00795	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D9623_00800	COG1138	Cytochrome C-type biogenesis protein
D9623_00805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9623_00810	COG3088	subunit of a heme lyase
D9623_00815	COG4235	cytochrome complex assembly
D9623_00820	COG0697	spore germination
D9623_00825	COG3339	Conserved Protein
D9623_00830	COG2897	thiosulfate sulfurtransferase activity
D9623_00845	COG0137	argininosuccinate synthase activity
D9623_00860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D9623_00870	COG1595	DNA-templated transcription, initiation
D9623_00890	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D9623_00900	COG0004	ammonium transporteR
D9623_00905	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D9623_00910	COG0297	glycogen (starch) synthase activity
D9623_00920	COG0481	GTPase activity
D9623_00930	COG0583	DNA-binding transcription factor activity
D9623_00940	COG0784	Response regulator, receiver
D9623_00940	COG3437	response regulator, receiver
D9623_00955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D9623_00960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D9623_00965	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D9623_00975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9623_00980	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D9623_01010	COG0583	DNA-binding transcription factor activity
D9623_01015	COG0477	Major facilitator Superfamily
D9623_01030	COG1253	flavin adenine dinucleotide binding
D9623_01035	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D9623_01055	COG2205	protein histidine kinase activity
D9623_01055	COG2202	Pas domain
D9623_01090	COG0803	Belongs to the bacterial solute-binding protein 9 family
D9623_01095	COG1121	(ABC) transporter
D9623_01100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9623_01100	COG1321	iron dependent repressor
D9623_01105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9623_01110	COG0784	Response regulator, receiver
D9623_01110	COG2205	protein histidine kinase activity
D9623_01110	COG5002	protein histidine kinase activity
D9623_01115	COG1278	Cold shock
D9623_01120	COG2204	response regulator
D9623_01125	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D9623_01130	COG0756	dUTP diphosphatase activity
D9623_01140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D9623_01150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D9623_01165	COG0745	RESPONSE REGULATOR receiver
D9623_01170	COG0704	Plays a role in the regulation of phosphate uptake
D9623_01175	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D9623_01185	COG0573	inorganic phosphate transmembrane transporter activity
D9623_01190	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D9623_01195	COG5002	protein histidine kinase activity
D9623_01200	COG0280	phosphate acetyltransferase
D9623_01200	COG0281	malic enzyme
D9623_01205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_01215	COG2217	Heavy metal translocating P-type atpase
D9623_01265	COG2132	Multicopper oxidase
D9623_01280	COG1177	transmembrane transport
D9623_01285	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_01305	COG3842	ATPase activity
D9623_01310	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D9623_01315	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D9623_01320	COG0268	Binds directly to 16S ribosomal RNA
D9623_01325	COG1024	Enoyl-CoA hydratase
D9623_01335	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D9623_01345	COG0457	Tetratricopeptide repeat
D9623_01345	COG0859	PFAM glycosyl transferase family 9
D9623_01350	COG2226	methyltransferase
D9623_01355	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D9623_01365	COG4166	transmembrane transport
D9623_01370	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D9623_01375	COG0039	L-malate dehydrogenase activity
D9623_01405	COG1592	Rubrerythrin
D9623_01420	COG0584	glycerophosphoryl diester phosphodiesterase
D9623_01425	COG1509	lysine 2,3-aminomutase activity
D9623_01435	COG2321	neutral zinc metallopeptidase
D9623_01445	COG1185	polyribonucleotide nucleotidyltransferase activity
D9623_01455	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D9623_01480	COG0779	Required for maturation of 30S ribosomal subunits
D9623_01485	COG2329	Antibiotic biosynthesis monooxygenase
D9623_01490	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D9623_01495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D9623_01500	COG1396	sequence-specific DNA binding
D9623_01505	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D9623_01510	COG1253	flavin adenine dinucleotide binding
D9623_01520	COG1702	phosphate starvation-inducible protein PhoH
D9623_01525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9623_01560	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D9623_01570	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D9623_01600	COG0730	response to heat
D9623_01605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9623_01620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D9623_01630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D9623_01635	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D9623_01645	COG1121	(ABC) transporter
D9623_01650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9623_01665	COG0840	transmembrane signaling receptor activity
D9623_01670	COG0247	lactate metabolic process
D9623_01675	COG1139	Iron-sulfur cluster binding protein
D9623_01680	COG1556	Lactate utilization protein
D9623_01695	COG2205	protein histidine kinase activity
D9623_01705	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D9623_01760	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D9623_01765	COG4395	Tim44
D9623_01775	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D9623_01780	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D9623_01825	COG0237	dephospho-CoA kinase activity
D9623_01830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9623_01840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D9623_01845	COG1331	Highly conserved protein containing a thioredoxin domain
D9623_01855	COG3411	Ferredoxin
D9623_01865	COG0445	tRNA wobble uridine modification
D9623_01870	COG0357	Ribosomal RNA small subunit methyltransferase G
D9623_01875	COG1192	Involved in chromosome partitioning
D9623_01880	COG1475	DNA binding
D9623_01945	COG0745	RESPONSE REGULATOR receiver
D9623_01965	COG1234	tRNA 3'-trailer cleavage
D9623_01975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_01980	COG0601	transmembrane transport
D9623_01985	COG0747	negative chemotaxis
D9623_02015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_02015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9623_02020	COG1132	(ABC) transporter
D9623_02035	COG3706	GGDEF domain
D9623_02040	COG0438	transferase activity, transferring glycosyl groups
D9623_02065	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D9623_02070	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D9623_02075	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D9623_02090	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_02095	COG1309	transcriptional regulator
D9623_02100	COG0110	maltose O-acetyltransferase activity
D9623_02115	COG3012	SEC-C Motif Domain Protein
D9623_02125	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D9623_02130	COG0180	Tryptophanyl-tRNA synthetase
D9623_02140	COG0784	Response regulator, receiver
D9623_02140	COG2205	protein histidine kinase activity
D9623_02180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D9623_02190	COG1366	Belongs to the anti-sigma-factor antagonist family
D9623_02210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D9623_02215	COG0792	nuclease activity
D9623_02245	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D9623_02250	COG0840	transmembrane signaling receptor activity
D9623_02255	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D9623_02260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D9623_02265	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D9623_02270	COG1420	regulation of RNA biosynthetic process
D9623_02280	COG0745	RESPONSE REGULATOR receiver
D9623_02305	COG0443	Heat shock 70 kDa protein
D9623_02315	COG3706	GGDEF domain
D9623_02325	COG4181	ATPase activity
D9623_02340	COG0667	Aldo Keto reductase
D9623_02345	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D9623_02350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D9623_02355	COG0347	Belongs to the P(II) protein family
D9623_02435	COG2264	protein methyltransferase activity
D9623_02470	COG3485	protocatechuate 3,4-dioxygenase
D9623_02475	COG0464	growth
D9623_02505	COG3436	PFAM IS66 Orf2 family protein
D9623_02510	COG4372	Transposase
D9623_02580	COG0747	negative chemotaxis
D9623_02595	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D9623_02610	COG3685	Protein conserved in bacteria
D9623_02630	COG1013	pyruvate-flavodoxin oxidoreductase activity
D9623_02635	COG0674	pyruvate-flavodoxin oxidoreductase activity
D9623_02635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D9623_02640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D9623_02645	COG2202	Pas domain
D9623_02645	COG2205	protein histidine kinase activity
D9623_02650	COG0693	protein deglycase activity
D9623_02655	COG2224	Isocitrate lyase
D9623_02660	COG1396	sequence-specific DNA binding
D9623_02660	COG3800	Transcriptional regulator
D9623_02675	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D9623_02680	COG0784	Response regulator, receiver
D9623_02680	COG3437	response regulator, receiver
D9623_02685	COG0668	transmembrane transport
D9623_02715	COG1612	heme a metabolic process
D9623_02720	COG0543	2 iron, 2 sulfur cluster binding
D9623_02720	COG0493	'glutamate synthase
D9623_02725	COG3772	lysozyme
D9623_02730	COG5425	PFAM Usg family protein
D9623_02735	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D9623_02740	COG0459	protein refolding
D9623_02745	COG0753	catalase activity
D9623_02750	COG1858	cytochrome C peroxidase
D9623_02755	COG3005	denitrification pathway
D9623_02770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D9623_02780	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D9623_02785	COG1842	Phage shock protein A
D9623_02795	COG1983	PspC domain protein
D9623_02810	COG0784	Response regulator, receiver
D9623_02810	COG3437	response regulator, receiver
D9623_02820	COG0671	phosphoesterase, PA-phosphatase related
D9623_02860	COG0747	negative chemotaxis
D9623_02870	COG0601	transmembrane transport
D9623_02880	COG0444	Belongs to the ABC transporter superfamily
D9623_02920	COG1278	Cold shock
D9623_02925	COG0033	Phosphoglucomutase
D9623_02930	COG0412	Dienelactone hydrolase
D9623_02935	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9623_02940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9623_02970	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_02975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D9623_03005	COG0514	ATP-dependent DNA helicase (RecQ)
D9623_03010	COG0494	nUDIX hydrolase
D9623_03020	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D9623_03025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9623_03030	COG0653	protein targeting
D9623_03035	COG1970	mechanosensitive ion channel activity
D9623_03040	COG0513	Belongs to the DEAD box helicase family
D9623_03045	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D9623_03070	COG1987	bacterial-type flagellum assembly
D9623_03075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D9623_03080	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D9623_03085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9623_03090	COG1971	Probably functions as a manganese efflux pump
D9623_03105	COG3162	membrane
D9623_03130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D9623_03155	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D9623_03185	COG0071	Belongs to the small heat shock protein (HSP20) family
D9623_03195	COG0463	Glycosyl transferase, family 2
D9623_03210	COG5002	protein histidine kinase activity
D9623_03210	COG2205	protein histidine kinase activity
D9623_03210	COG0784	Response regulator, receiver
D9623_03215	COG0745	RESPONSE REGULATOR receiver
D9623_03215	COG3706	GGDEF domain
D9623_03230	COG1741	Belongs to the pirin family
D9623_03245	COG0405	Gamma-glutamyltransferase
D9623_03260	COG0539	negative regulation of cytoplasmic translation
D9623_03270	COG0776	regulation of translation
D9623_03280	COG2423	ornithine cyclodeaminase activity
D9623_03300	COG0135	phosphoribosylanthranilate isomerase activity
D9623_03305	COG0745	RESPONSE REGULATOR receiver
D9623_03305	COG3706	GGDEF domain
D9623_03310	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D9623_03315	COG1178	ABC-type Fe3 transport system permease component
D9623_03320	COG1741	Belongs to the pirin family
D9623_03325	COG1840	ABC-type Fe3 transport system, periplasmic component
D9623_03355	COG0271	Belongs to the BolA IbaG family
D9623_03370	COG0517	IMP dehydrogenase activity
D9623_03375	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D9623_03395	COG4974	Belongs to the 'phage' integrase family
D9623_03400	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D9623_03410	COG0825	malonyl-CoA metabolic process
D9623_03425	COG0598	Magnesium transport protein CorA
D9623_03435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D9623_03450	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D9623_03455	COG0706	membrane insertase activity
D9623_03460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D9623_03470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D9623_03510	COG0438	transferase activity, transferring glycosyl groups
D9623_03525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9623_03535	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D9623_03545	COG3206	protein involved in exopolysaccharide biosynthesis
D9623_03545	COG0489	protein tyrosine kinase activity
D9623_03560	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D9623_03570	COG1131	(ABC) transporter
D9623_03580	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9623_03595	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D9623_03610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_03650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D9623_03655	COG0228	four-way junction DNA binding
D9623_03660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D9623_03670	COG0335	large ribosomal subunit rRNA binding
D9623_03685	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D9623_03690	COG2378	regulation of single-species biofilm formation
D9623_03705	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_03710	COG0101	tRNA pseudouridine synthase activity
D9623_03715	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D9623_03720	COG0242	peptide deformylase activity
D9623_03730	COG1278	Cold shock
D9623_03735	COG1322	Protein conserved in bacteria
D9623_03750	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_03765	COG0156	8-amino-7-oxononanoate synthase activity
D9623_03775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9623_03780	COG0625	glutathione transferase activity
D9623_03785	COG5001	Diguanylate cyclase
D9623_03800	COG0583	DNA-binding transcription factor activity
D9623_03830	COG0625	glutathione transferase activity
D9623_03835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D9623_03855	COG4544	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
D9623_03870	COG0587	DNA-directed DNA polymerase activity
D9623_03875	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9623_03900	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D9623_03905	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9623_03940	COG4172	Belongs to the ABC transporter superfamily
D9623_03945	COG4239	(ABC) transporter, permease
D9623_03950	COG4174	ABC transporter (Permease)
D9623_03955	COG4166	transmembrane transport
D9623_03965	COG4166	transmembrane transport
D9623_03970	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D9623_03995	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D9623_04000	COG3474	cytochrome
D9623_04015	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D9623_04025	COG0126	phosphoglycerate kinase activity
D9623_04030	COG2226	methyltransferase
D9623_04050	COG4106	trans-aconitate 2-methyltransferase activity
D9623_04060	COG4191	Histidine kinase
D9623_04080	COG0596	Alpha beta hydrolase
D9623_04090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9623_04095	COG4974	Belongs to the 'phage' integrase family
D9623_04105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D9623_04125	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9623_04135	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D9623_04155	COG1051	belongs to the nudix hydrolase family
D9623_04165	COG0793	Belongs to the peptidase S41A family
D9623_04175	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D9623_04180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D9623_04185	COG0799	negative regulation of ribosome biogenesis
D9623_04200	COG2010	Cytochrome c
D9623_04200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D9623_04220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D9623_04230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D9623_04240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D9623_04280	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D9623_04300	COG0840	transmembrane signaling receptor activity
D9623_04305	COG0463	Glycosyl transferase, family 2
D9623_04315	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D9623_04330	COG0723	plastoquinol--plastocyanin reductase activity
D9623_04360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D9623_04370	COG2205	protein histidine kinase activity
D9623_04380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9623_04390	COG3279	Response regulator of the LytR AlgR family
D9623_04405	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D9623_04415	COG1902	pentaerythritol trinitrate reductase activity
D9623_04425	COG2962	Rard protein
D9623_04435	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D9623_04445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D9623_04450	COG0047	phosphoribosylformylglycinamidine synthase activity
D9623_04455	COG0583	DNA-binding transcription factor activity
D9623_04465	COG2258	MOSC domain
D9623_04475	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D9623_04480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D9623_04495	COG0601	transmembrane transport
D9623_04500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_04505	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D9623_04525	COG0024	Methionine aminopeptidase
D9623_04530	COG1489	DNA binding
D9623_04535	COG1058	Belongs to the CinA family
D9623_04535	COG1546	Belongs to the CinA family
D9623_04575	COG0124	histidyl-tRNA synthetase
D9623_04580	COG0418	dihydroorotase activity
D9623_04590	COG1570	exodeoxyribonuclease VII activity
D9623_04605	COG0590	tRNA wobble adenosine to inosine editing
D9623_04610	COG3360	Dodecin
D9623_04615	COG1187	pseudouridine synthase activity
D9623_04620	COG0742	ribosomal rna small subunit methyltransferase
D9623_04635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9623_04675	COG1518	maintenance of DNA repeat elements
D9623_04685	COG1309	transcriptional regulator
D9623_04715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9623_04720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9623_04730	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D9623_04765	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_04770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9623_04795	COG0667	Aldo Keto reductase
D9623_04800	COG2188	Transcriptional regulator
D9623_04805	COG0179	Fumarylacetoacetate (FAA) hydrolase
D9623_04830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D9623_04835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9623_04860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9623_04875	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9623_04895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D9623_04915	COG0166	Belongs to the GPI family
D9623_04925	COG0612	Peptidase, M16
D9623_04930	COG0612	Peptidase, M16
D9623_04940	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D9623_04945	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D9623_04950	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D9623_04955	COG0196	riboflavin kinase activity
D9623_04960	COG2030	dehydratase
D9623_04970	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D9623_05000	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9623_05005	COG2703	oxygen carrier activity
D9623_05020	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9623_05050	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D9623_05055	COG2089	acid synthase
D9623_05080	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_05110	COG1294	oxidase, subunit
D9623_05115	COG1271	oxidase subunit
D9623_05120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9623_05140	COG1127	ABC transporter
D9623_05145	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D9623_05150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9623_05205	COG0583	DNA-binding transcription factor activity
D9623_05210	COG0667	Aldo Keto reductase
D9623_05230	COG0583	DNA-binding transcription factor activity
D9623_05275	COG0511	ligase activity, forming carbon-carbon bonds
D9623_05280	COG0439	Biotin carboxylase
D9623_05285	COG3719	Belongs to the RNase T2 family
D9623_05310	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D9623_05335	COG1686	Belongs to the peptidase S11 family
D9623_05350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D9623_05355	COG0746	molybdenum cofactor guanylyltransferase activity
D9623_05380	COG3383	formate dehydrogenase (NAD+) activity
D9623_05380	COG0243	molybdopterin cofactor binding
D9623_05385	COG0437	4 iron, 4 sulfur cluster binding
D9623_05410	COG0235	Class ii aldolase
D9623_05420	COG3384	dioxygenase
D9623_05430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9623_05435	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9623_05440	COG0356	it plays a direct role in the translocation of protons across the membrane
D9623_05450	COG1999	signal sequence binding
D9623_05460	COG0840	transmembrane signaling receptor activity
D9623_05465	COG1702	phosphate starvation-inducible protein PhoH
D9623_05470	COG0850	regulation of cytokinetic process
D9623_05475	COG2894	cell division
D9623_05480	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D9623_05495	COG0840	transmembrane signaling receptor activity
D9623_05505	COG4948	Mandelate Racemase Muconate Lactonizing
D9623_05515	COG1104	cysteine desulfurase activity
D9623_05525	COG2154	pterin-4-alpha-carbinolamine dehydratase
D9623_05540	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D9623_05555	COG0840	transmembrane signaling receptor activity
D9623_05560	COG0840	transmembrane signaling receptor activity
D9623_05565	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D9623_05570	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D9623_05575	COG1278	Cold shock
D9623_05610	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D9623_05665	COG5420	small protein containing a coiled-coil domain
D9623_05680	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D9623_05685	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D9623_05740	COG0121	glutamine amidotransferase
D9623_05755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D9623_05780	COG5554	nitrogen fixation
D9623_05795	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D9623_05820	COG1309	transcriptional regulator
D9623_05830	COG1131	(ABC) transporter
D9623_05840	COG0842	Transport permease protein
D9623_05845	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D9623_05855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D9623_05860	COG0277	FAD linked oxidase domain protein
D9623_05865	COG0277	FAD linked oxidase domain protein
D9623_05870	COG0247	lactate metabolic process
D9623_05890	COG1960	acyl-CoA dehydrogenase activity
D9623_05905	COG0277	FAD linked oxidase domain protein
D9623_05910	COG0009	L-threonylcarbamoyladenylate synthase
D9623_05915	COG1192	Involved in chromosome partitioning
D9623_05925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D9623_05930	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D9623_05945	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D9623_05950	COG2945	thiolester hydrolase activity
D9623_05955	COG1045	serine acetyltransferase
D9623_05970	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D9623_05975	COG0633	Ferredoxin
D9623_05980	COG0482	sulfurtransferase activity
D9623_05995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_06020	COG4221	oxidoreductase activity
D9623_06030	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D9623_06045	COG0784	Response regulator, receiver
D9623_06045	COG2205	protein histidine kinase activity
D9623_06055	COG0745	RESPONSE REGULATOR receiver
D9623_06080	COG0432	Pfam Uncharacterised protein family UPF0047
D9623_06090	COG2951	lytic endotransglycosylase activity
D9623_06110	COG1454	alcohol dehydrogenase
D9623_06135	COG0456	acetyltransferase
D9623_06150	COG0114	fumarate hydratase activity
D9623_06165	COG5002	protein histidine kinase activity
D9623_06165	COG5001	Diguanylate cyclase
D9623_06170	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D9623_06185	COG0205	6-phosphofructokinase activity
D9623_06215	COG0288	reversible hydration of carbon dioxide
D9623_06275	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_06285	COG0840	transmembrane signaling receptor activity
D9623_06305	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D9623_06310	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D9623_06315	COG0343	queuine tRNA-ribosyltransferase activity
D9623_06320	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D9623_06325	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D9623_06330	COG0840	transmembrane signaling receptor activity
D9623_06400	COG2201	protein-glutamate methylesterase activity
D9623_06435	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D9623_06445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D9623_06450	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D9623_06455	COG0242	peptide deformylase activity
D9623_06465	COG3070	regulator of competence-specific genes
D9623_06480	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D9623_06505	COG4120	Belongs to the binding-protein-dependent transport system permease family
D9623_06510	COG0410	ABC transporter
D9623_06520	COG0489	protein tyrosine kinase activity
D9623_06525	COG0330	HflC and HflK could
D9623_06530	COG0330	HflC and HflK could
D9623_06555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D9623_06560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9623_06565	COG0028	Belongs to the TPP enzyme family
D9623_06580	COG0704	Plays a role in the regulation of phosphate uptake
D9623_06585	COG2862	Uncharacterized protein family, UPF0114
D9623_06605	COG0768	penicillin binding
D9623_06610	COG0840	transmembrane signaling receptor activity
D9623_06645	COG0295	cytidine deaminase activity
D9623_06650	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D9623_06655	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D9623_06670	COG0697	spore germination
D9623_06690	COG0411	ABC transporter
D9623_06705	COG0038	chloride channel
D9623_06715	COG2326	polyphosphate kinase activity
D9623_06720	COG0366	Alpha amylase catalytic
D9623_06730	COG2199	diguanylate cyclase activity
D9623_06730	COG2200	EAL domain
D9623_06730	COG2203	Gaf domain
D9623_06740	COG2135	peptidase activity
D9623_06750	COG0784	Response regulator, receiver
D9623_06755	COG2261	transglycosylase associated protein
D9623_06760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D9623_06775	COG1733	regulation of RNA biosynthetic process
D9623_06785	COG2084	Dehydrogenase
D9623_06790	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_06805	COG0546	phosphoglycolate phosphatase activity
D9623_06820	COG0521	Mo-molybdopterin cofactor biosynthetic process
D9623_06830	COG2832	Protein of unknown function (DUF454)
D9623_06835	COG1238	metal cluster binding
D9623_06840	COG3852	Histidine kinase
D9623_06845	COG0469	pyruvate kinase activity
D9623_06850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D9623_06865	COG0203	ribosomal protein L17
D9623_06870	COG1238	metal cluster binding
D9623_06885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D9623_06895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D9623_06900	COG0564	pseudouridine synthase activity
D9623_06905	COG1802	Transcriptional regulator
D9623_06910	COG3135	benzoate transporter
D9623_06915	COG0546	phosphoglycolate phosphatase activity
D9623_06940	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9623_06945	COG1129	ABC transporter
D9623_06985	COG3706	GGDEF domain
D9623_06985	COG0745	RESPONSE REGULATOR receiver
D9623_06990	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D9623_06995	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D9623_07010	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_07015	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D9623_07020	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D9623_07030	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D9623_07035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D9623_07040	COG0351	phosphomethylpyrimidine kinase
D9623_07045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9623_07065	COG4325	translation initiation factor activity
D9623_07085	COG1012	belongs to the aldehyde dehydrogenase family
D9623_07085	COG2030	dehydratase
D9623_07090	COG0443	Heat shock 70 kDa protein
D9623_07115	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D9623_07115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D9623_07165	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9623_07170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9623_07180	COG0649	NAD binding
D9623_07185	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D9623_07195	COG1034	ATP synthesis coupled electron transport
D9623_07200	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D9623_07205	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9623_07215	COG0713	ATP synthesis coupled electron transport
D9623_07230	COG1007	ATP synthesis coupled electron transport
D9623_07260	COG0519	Catalyzes the synthesis of GMP from XMP
D9623_07275	COG0442	prolyl-tRNA aminoacylation
D9623_07305	COG0587	DNA-directed DNA polymerase activity
D9623_07310	COG0052	Belongs to the universal ribosomal protein uS2 family
D9623_07315	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D9623_07320	COG0528	UMP kinase activity
D9623_07325	COG0233	cytoplasmic translational termination
D9623_07330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D9623_07335	COG0575	Belongs to the CDS family
D9623_07340	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D9623_07345	COG0750	zinc metalloprotease
D9623_07365	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9623_07370	COG3494	Protein of unknown function (DUF1009)
D9623_07375	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9623_07390	COG0583	DNA-binding transcription factor activity
D9623_07405	COG0372	Belongs to the citrate synthase family
D9623_07410	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9623_07415	COG2333	competence protein COMEC
D9623_07415	COG0658	competence protein
D9623_07420	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D9623_07425	COG0303	'Molybdopterin
D9623_07430	COG0315	cyclic pyranopterin monophosphate synthase activity
D9623_07475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D9623_07485	COG0149	triose-phosphate isomerase activity
D9623_07515	COG0535	radical SAM domain protein
D9623_07520	COG0535	radical SAM domain protein
D9623_07525	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
D9623_07530	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D9623_07540	COG0148	phosphopyruvate hydratase activity
D9623_07550	COG0037	tRNA processing
D9623_07585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_07605	COG0596	Alpha beta hydrolase
D9623_07610	COG0728	peptidoglycan biosynthetic process
D9623_07620	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9623_07635	COG0436	Aminotransferase
D9623_07655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_07660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9623_07685	COG0745	RESPONSE REGULATOR receiver
D9623_07690	COG0840	transmembrane signaling receptor activity
D9623_07720	COG2205	protein histidine kinase activity
D9623_07725	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D9623_07755	COG1024	Enoyl-CoA hydratase
D9623_07765	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D9623_07770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D9623_07775	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D9623_07780	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D9623_07785	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D9623_07785	COG2885	chlorophyll binding
D9623_07790	COG3243	poly(R)-hydroxyalkanoic acid synthase
D9623_07815	COG0436	Aminotransferase
D9623_07825	COG1494	fructose-1,6-bisphosphatase
D9623_07835	COG0371	Dehydrogenase
D9623_07840	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D9623_07840	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D9623_07905	COG0656	L-ascorbic acid biosynthetic process
D9623_07930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9623_07935	COG0517	IMP dehydrogenase activity
D9623_07950	COG2814	Major facilitator Superfamily
D9623_07965	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D9623_07980	COG2084	Dehydrogenase
D9623_07985	COG3622	Belongs to the hyi family
D9623_07990	COG3960	tartronate-semialdehyde synthase activity
D9623_07995	COG0352	thiamine-phosphate diphosphorylase activity
D9623_07995	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D9623_08000	COG1802	Transcriptional regulator
D9623_08005	COG0469	pyruvate kinase activity
D9623_08015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D9623_08015	COG0574	Belongs to the PEP-utilizing enzyme family
D9623_08040	COG3283	Transcriptional regulator of aromatic amino acids metabolism
D9623_08045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_08055	COG0693	protein deglycase activity
D9623_08060	COG2197	response regulator
D9623_08065	COG2197	response regulator
D9623_08080	COG0829	nickel cation binding
D9623_08085	COG0831	urea catabolic process
D9623_08090	COG0832	Belongs to the urease beta subunit family
D9623_08095	COG0804	urea catabolic process
D9623_08100	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D9623_08105	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D9623_08110	COG0830	nickel cation binding
D9623_08115	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D9623_08120	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
D9623_08130	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D9623_08145	COG0640	Transcriptional regulator
D9623_08175	COG1396	sequence-specific DNA binding
D9623_08200	COG1846	Transcriptional regulator
D9623_08210	COG0704	Plays a role in the regulation of phosphate uptake
D9623_08230	COG0463	Glycosyl transferase, family 2
D9623_08250	COG1940	carbohydrate kinase activity
D9623_08275	COG0410	ABC transporter
D9623_08300	COG2885	chlorophyll binding
D9623_08300	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D9623_08305	COG2197	response regulator
D9623_08310	COG2198	Histidine kinase
D9623_08310	COG0784	Response regulator, receiver
D9623_08310	COG2205	protein histidine kinase activity
D9623_08325	COG0564	pseudouridine synthase activity
D9623_08330	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_08335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D9623_08350	COG0024	Methionine aminopeptidase
D9623_08365	COG1127	ABC transporter
D9623_08370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D9623_08375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D9623_08380	COG0305	Participates in initiation and elongation during chromosome replication
D9623_08385	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D9623_08390	COG0359	binds to the 23S rRNA
D9623_08400	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D9623_08405	COG0360	Binds together with S18 to 16S ribosomal RNA
D9623_08410	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D9623_08425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9623_08430	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D9623_08440	COG0741	lytic transglycosylase activity
D9623_08445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9623_08450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D9623_08455	COG2813	Specifically methylates the guanine in position
D9623_08465	COG1881	PFAM PEBP family protein
D9623_08470	COG0113	porphobilinogen synthase activity
D9623_08475	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D9623_08480	COG1597	lipid kinase activity
D9623_08485	COG1024	Enoyl-CoA hydratase
D9623_08490	COG1846	Transcriptional regulator
D9623_08510	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_08525	COG0686	Belongs to the AlaDH PNT family
D9623_08535	COG0737	Belongs to the 5'-nucleotidase family
D9623_08540	COG0512	Glutamine amidotransferase of anthranilate synthase
D9623_08545	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D9623_08550	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D9623_08550	COG3608	succinylglutamate desuccinylase aspartoacylase
D9623_08615	COG0123	including yeast histone deacetylase and acetoin utilization protein
D9623_08660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D9623_08665	COG0626	cystathionine gamma-synthase activity
D9623_08670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_08675	COG4597	amino acid ABC transporter
D9623_08680	COG0765	amino acid transport
D9623_08685	COG1126	abc transporter atp-binding protein
D9623_08690	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D9623_08710	COG2897	thiosulfate sulfurtransferase activity
D9623_08725	COG0494	nUDIX hydrolase
D9623_08730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9623_08755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D9623_08765	COG1538	Outer membrane efflux protein
D9623_08775	COG0525	valine-tRNA ligase activity
D9623_08780	COG0840	transmembrane signaling receptor activity
D9623_08795	COG1686	Belongs to the peptidase S11 family
D9623_08800	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D9623_08805	COG0470	DNA polymerase III
D9623_08810	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9623_08815	COG0084	hydrolase, TatD family'
D9623_08820	COG0321	lipoyl(octanoyl) transferase activity
D9623_08820	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D9623_08835	COG0631	protein serine/threonine phosphatase activity
D9623_08845	COG2957	Belongs to the agmatine deiminase family
D9623_08850	COG1177	transmembrane transport
D9623_08855	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_08860	COG3842	ATPase activity
D9623_08870	COG0174	glutamine synthetase
D9623_08875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_08905	COG0861	Integral membrane protein TerC family
D9623_08915	COG4957	zinc ion binding
D9623_08925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9623_08950	COG1280	lysine exporter protein (LysE YggA)
D9623_08960	COG0314	molybdopterin synthase activity
D9623_08965	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D9623_08975	COG1763	Mo-molybdopterin cofactor biosynthetic process
D9623_08980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D9623_08990	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_09010	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D9623_09055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9623_09060	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_09065	COG0625	glutathione transferase activity
D9623_09080	COG0745	RESPONSE REGULATOR receiver
D9623_09135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D9623_09140	COG1692	metallophosphoesterase
D9623_09145	COG0217	transcriptional regulatory protein
D9623_09160	COG2255	four-way junction helicase activity
D9623_09165	COG0824	Thioesterase
D9623_09175	COG0848	biopolymer transport protein
D9623_09190	COG2885	chlorophyll binding
D9623_09200	COG1086	Polysaccharide biosynthesis protein
D9623_09210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9623_09215	COG0438	transferase activity, transferring glycosyl groups
D9623_09230	COG0367	asparagine synthase
D9623_09235	COG0697	spore germination
D9623_09245	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D9623_09255	COG1765	OsmC-like protein
D9623_09260	COG0300	oxidoreductase activity
D9623_09265	COG2076	Multidrug Resistance protein
D9623_09285	COG0784	Response regulator, receiver
D9623_09285	COG3437	response regulator, receiver
D9623_09300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_09300	COG4191	Histidine kinase
D9623_09325	COG0484	heat shock protein binding
D9623_09330	COG4520	surface antigen
D9623_09345	COG0840	transmembrane signaling receptor activity
D9623_09350	COG0840	transmembrane signaling receptor activity
D9623_09360	COG1234	tRNA 3'-trailer cleavage
D9623_09365	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D9623_09370	COG0463	Glycosyl transferase, family 2
D9623_09380	COG0523	cobalamin synthesis protein
D9623_09385	COG0735	belongs to the Fur family
D9623_09395	COG0415	Belongs to the DNA photolyase family
D9623_09400	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D9623_09410	COG1201	RNA secondary structure unwinding
D9623_09430	COG2226	methyltransferase
D9623_09445	COG2267	carboxylic ester hydrolase activity
D9623_09450	COG1846	Transcriptional regulator
D9623_09460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_09500	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D9623_09505	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_09510	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_09515	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_09520	COG1960	acyl-CoA dehydrogenase activity
D9623_09535	COG2833	Protein of unknown function (DUF455)
D9623_09540	COG1218	3'(2'),5'-bisphosphate nucleotidase
D9623_09555	COG0366	Alpha amylase catalytic
D9623_09560	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D9623_09570	COG0745	RESPONSE REGULATOR receiver
D9623_09575	COG1640	4-alpha-glucanotransferase
D9623_09600	COG2176	DNA-directed DNA polymerase activity
D9623_09600	COG5002	protein histidine kinase activity
D9623_09605	COG1671	Belongs to the UPF0178 family
D9623_09610	COG0488	(ABC) transporter
D9623_09625	COG2853	Lipoprotein
D9623_09645	COG1410	methionine synthase
D9623_09645	COG0646	methionine synthase
D9623_09660	COG3706	GGDEF domain
D9623_09665	COG2070	2-Nitropropane dioxygenase
D9623_09670	COG0243	molybdopterin cofactor binding
D9623_09680	COG0840	transmembrane signaling receptor activity
D9623_09685	COG2824	Alkylphosphonate utilization operon protein PhnA
D9623_09715	COG2205	protein histidine kinase activity
D9623_09715	COG2202	Pas domain
D9623_09735	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D9623_09740	COG1752	Esterase of the alpha-beta hydrolase superfamily
D9623_09755	COG1773	rubredoxin
D9623_09765	COG3108	Peptidase M15
D9623_09780	COG0546	phosphoglycolate phosphatase activity
D9623_09825	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D9623_09830	COG2211	Major facilitator Superfamily
D9623_09835	COG3546	catalase activity
D9623_09855	COG3411	Ferredoxin
D9623_09860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D9623_09870	COG1024	Enoyl-CoA hydratase
D9623_09880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D9623_09940	COG1492	cobalamin metabolic process
D9623_09945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D9623_09965	COG3424	synthase
D9623_09970	COG1755	Isoprenylcysteine carboxyl methyltransferase
D9623_09990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_10040	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D9623_10050	COG2313	pseudouridylate synthase activity
D9623_10060	COG1793	dna ligase
D9623_10070	COG2153	protein acetylation
D9623_10090	COG3685	Protein conserved in bacteria
D9623_10110	COG0698	ribose 5-phosphate isomerase
D9623_10115	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D9623_10120	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D9623_10125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9623_10125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9623_10135	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9623_10135	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9623_10140	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D9623_10145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D9623_10150	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D9623_10160	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D9623_10180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D9623_10185	COG0416	fatty acid biosynthetic process
D9623_10190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9623_10215	COG4651	solute:proton antiporter activity
D9623_10215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D9623_10230	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9623_10245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D9623_10245	COG1648	precorrin-2 dehydrogenase activity
D9623_10250	COG0175	sulfate reduction
D9623_10255	COG0175	sulfate reduction
D9623_10265	COG1116	anion transmembrane transporter activity
D9623_10265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9623_10275	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D9623_10295	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_10300	COG0789	Transcriptional regulator
D9623_10315	COG2814	Major facilitator Superfamily
D9623_10320	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D9623_10350	COG0745	RESPONSE REGULATOR receiver
D9623_10350	COG3706	GGDEF domain
D9623_10360	COG0840	transmembrane signaling receptor activity
D9623_10390	COG2197	response regulator
D9623_10400	COG2197	response regulator
D9623_10420	COG1160	GTP binding
D9623_10425	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D9623_10425	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D9623_10465	COG1012	belongs to the aldehyde dehydrogenase family
D9623_10485	COG0668	transmembrane transport
D9623_10515	COG1830	Aldolase
D9623_10520	COG0352	thiamine-phosphate diphosphorylase activity
D9623_10525	COG0730	response to heat
D9623_10530	COG2067	long-chain fatty acid transport protein
D9623_10535	COG0604	alcohol dehydrogenase
D9623_10540	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D9623_10545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D9623_10550	COG0483	inositol monophosphate 1-phosphatase activity
D9623_10575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9623_10580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9623_10580	COG1565	acr, cog1565
D9623_10590	COG0312	modulator of DNA gyrase
D9623_10595	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D9623_10600	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9623_10610	COG5487	UPF0391 membrane protein
D9623_10620	COG0741	lytic transglycosylase activity
D9623_10650	COG0564	pseudouridine synthase activity
D9623_10655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9623_10670	COG0515	serine threonine protein kinase
D9623_10670	COG3266	domain, Protein
D9623_10675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D9623_10680	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D9623_10690	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D9623_10705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D9623_10710	COG1295	ribonuclease BN
D9623_10715	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D9623_10725	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D9623_10735	COG0745	RESPONSE REGULATOR receiver
D9623_10745	COG0616	signal peptide processing
D9623_10760	COG0784	Response regulator, receiver
D9623_10760	COG2198	Histidine kinase
D9623_10760	COG5002	protein histidine kinase activity
D9623_10770	COG0390	transport system, permease component
D9623_10775	COG0577	efflux transmembrane transporter activity
D9623_10775	COG1136	(ABC) transporter
D9623_10785	COG0628	permease
D9623_10790	COG2205	protein histidine kinase activity
D9623_10800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9623_10810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D9623_10815	COG0251	oxidation-reduction process
D9623_10825	COG0551	DNA topoisomerase type I activity
D9623_10825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9623_10855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D9623_10865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9623_10880	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D9623_10880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D9623_10890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9623_10905	COG0505	Belongs to the CarA family
D9623_10915	COG1403	HNH endonuclease
D9623_10925	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9623_10930	COG1393	Belongs to the ArsC family
D9623_10935	COG2890	protein-(glutamine-N5) methyltransferase activity
D9623_10940	COG0456	acetyltransferase
D9623_10940	COG1214	PFAM Peptidase M22, glycoprotease
D9623_10980	COG0538	isocitrate dehydrogenase activity
D9623_10990	COG3932	Exopolysaccharide synthesis, ExoD
D9623_11010	COG0473	3-isopropylmalate dehydrogenase activity
D9623_11040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D9623_11060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9623_11075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D9623_11095	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9623_11100	COG1684	flagellar biosynthetic protein fliR
D9623_11105	COG1987	bacterial-type flagellum assembly
D9623_11110	COG1677	Flagellar hook-basal body complex protein FliE
D9623_11115	COG1558	bacterial-type flagellum-dependent cell motility
D9623_11120	COG1815	bacterial-type flagellum-dependent cell motility
D9623_11125	COG2257	FlhB HrpN YscU SpaS Family
D9623_11140	COG1338	Plays a role in the flagellum-specific transport system
D9623_11155	COG1360	Flagellar Motor Protein
D9623_11195	COG4786	Flagellar basal body rod
D9623_11200	COG4786	Flagellar basal body rod
D9623_11210	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D9623_11220	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D9623_11250	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D9623_11275	COG0500	methyltransferase
D9623_11285	COG1132	(ABC) transporter
D9623_11290	COG0254	rRNA binding
D9623_11300	COG0071	Belongs to the small heat shock protein (HSP20) family
D9623_11320	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D9623_11335	COG2186	Transcriptional regulator
D9623_11340	COG0563	adenylate kinase activity
D9623_11345	COG0201	protein transport
D9623_11350	COG0200	Binds to the 23S rRNA
D9623_11355	COG1841	ribosomal large subunit assembly
D9623_11370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D9623_11375	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D9623_11380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D9623_11390	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D9623_11400	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D9623_11405	COG0255	Belongs to the universal ribosomal protein uL29 family
D9623_11410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D9623_11415	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D9623_11420	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D9623_11425	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D9623_11430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D9623_11435	COG0089	rRNA binding
D9623_11440	COG0088	Forms part of the polypeptide exit tunnel
D9623_11450	COG0051	transcription antitermination factor activity, RNA binding
D9623_11455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D9623_11520	COG0410	ABC transporter
D9623_11535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D9623_11545	COG1940	carbohydrate kinase activity
D9623_11560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_11565	COG0410	ABC transporter
D9623_11570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D9623_11575	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D9623_11580	COG0509	glycine decarboxylation via glycine cleavage system
D9623_11585	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D9623_11600	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D9623_11605	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9623_11615	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_11620	COG0678	peroxiredoxin activity
D9623_11625	COG4232	protein-disulfide reductase activity
D9623_11630	COG1678	Uncharacterized ACR, COG1678
D9623_11640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9623_11645	COG0612	Peptidase, M16
D9623_11655	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D9623_11660	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D9623_11665	COG3346	SURF1 family
D9623_11690	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D9623_11700	COG0049	tRNA binding
D9623_11715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D9623_11720	COG0085	RNA polymerase activity
D9623_11725	COG0222	ribosome binding
D9623_11730	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D9623_11735	COG0081	regulation of translation
D9623_11740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D9623_11760	COG0411	ABC transporter
D9623_11770	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_11795	COG0673	inositol 2-dehydrogenase activity
D9623_11805	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D9623_11815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_11820	COG1309	transcriptional regulator
D9623_11830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D9623_11850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9623_11890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D9623_11895	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9623_11900	COG1530	ribonuclease E activity
D9623_11940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D9623_11955	COG2264	protein methyltransferase activity
D9623_11965	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D9623_11980	COG0312	modulator of DNA gyrase
D9623_11990	COG1597	lipid kinase activity
D9623_12000	COG0438	transferase activity, transferring glycosyl groups
D9623_12010	COG1519	Transferase
D9623_12015	COG1663	tetraacyldisaccharide 4'-kinase activity
D9623_12050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9623_12060	COG0590	tRNA wobble adenosine to inosine editing
D9623_12095	COG3108	Peptidase M15
D9623_12100	COG3409	Peptidoglycan-binding domain 1 protein
D9623_12100	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9623_12130	COG2205	protein histidine kinase activity
D9623_12140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D9623_12165	COG1073	alpha beta
D9623_12170	COG1380	Effector of murein hydrolase LrgA
D9623_12175	COG1346	cytolysis
D9623_12180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9623_12185	COG0751	glycine-tRNA ligase activity
D9623_12190	COG0752	glycyl-tRNA synthetase alpha subunit
D9623_12210	COG2890	protein-(glutamine-N5) methyltransferase activity
D9623_12220	COG0142	geranyltranstransferase activity
D9623_12245	COG0784	Response regulator, receiver
D9623_12245	COG4191	Histidine kinase
D9623_12260	COG2084	Dehydrogenase
D9623_12265	COG0277	FAD linked oxidase domain protein
D9623_12280	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D9623_12305	COG2001	Belongs to the MraZ family
D9623_12325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D9623_12335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9623_12350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D9623_12360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D9623_12365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D9623_12370	COG1181	Belongs to the D-alanine--D-alanine ligase family
D9623_12375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D9623_12380	COG0849	cell division
D9623_12385	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D9623_12400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D9623_12420	COG0497	DNA recombination
D9623_12425	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9623_12440	COG0745	RESPONSE REGULATOR receiver
D9623_12445	COG0006	proline dipeptidase activity
D9623_12445	COG0006	proline dipeptidase activity
D9623_12455	COG2264	protein methyltransferase activity
D9623_12470	COG0210	DNA helicase
D9623_12475	COG2197	response regulator
D9623_12480	COG2197	response regulator
D9623_12510	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D9623_12520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D9623_12530	COG2205	protein histidine kinase activity
D9623_12540	COG2202	Pas domain
D9623_12540	COG2205	protein histidine kinase activity
D9623_12580	COG2988	succinylglutamate desuccinylase activity
D9623_12585	COG3180	Ammonia monooxygenase
D9623_12595	COG0628	permease
D9623_12600	COG0330	HflC and HflK could
D9623_12625	COG0745	RESPONSE REGULATOR receiver
D9623_12645	COG1116	anion transmembrane transporter activity
D9623_12650	COG1643	Atp-dependent helicase
D9623_12665	COG2719	SpoVR family
D9623_12670	COG2718	Belongs to the UPF0229 family
D9623_12675	COG2766	serine protein kinase
D9623_12680	COG0745	RESPONSE REGULATOR receiver
D9623_12690	COG2205	protein histidine kinase activity
D9623_12690	COG0784	Response regulator, receiver
D9623_12700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9623_12715	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D9623_12755	COG1116	anion transmembrane transporter activity
D9623_12805	COG1131	(ABC) transporter
D9623_12815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_12815	COG2205	protein histidine kinase activity
D9623_12830	COG1012	belongs to the aldehyde dehydrogenase family
D9623_12850	COG1238	metal cluster binding
D9623_12855	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_12860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D9623_12870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9623_12890	COG1674	ftsk spoiiie
D9623_12915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D9623_12920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9623_12930	COG1522	sequence-specific DNA binding
D9623_12935	COG3660	Nucleoside-diphosphate-sugar epimerase
D9623_12950	COG0492	ferredoxin-NADP+ reductase activity
D9623_12960	COG0783	Belongs to the Dps family
D9623_12970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9623_12975	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D9623_13020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9623_13025	COG2304	oxidoreductase activity
D9623_13055	COG1136	(ABC) transporter
D9623_13085	COG0411	ABC transporter
D9623_13095	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_13105	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_13110	COG0154	amidase activity
D9623_13120	COG1024	Enoyl-CoA hydratase
D9623_13125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9623_13130	COG0583	DNA-binding transcription factor activity
D9623_13145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D9623_13155	COG0714	Associated with various cellular activities
D9623_13190	COG3119	arylsulfatase activity
D9623_13255	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D9623_13260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D9623_13265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D9623_13275	COG0167	dihydroorotate dehydrogenase activity
D9623_13395	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9623_13415	COG1442	glycosyl transferase family 8
D9623_13415	COG1216	Glycosyl transferase, family 2
D9623_13425	COG4178	(ABC) transporter
D9623_13435	COG2723	6-phospho-beta-galactosidase activity
D9623_13440	COG2723	6-phospho-beta-galactosidase activity
D9623_13460	COG2819	hydrolase of the alpha beta superfamily
D9623_13495	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D9623_13500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D9623_13505	COG1960	acyl-CoA dehydrogenase activity
D9623_13540	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D9623_13550	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D9623_13560	COG3485	protocatechuate 3,4-dioxygenase
D9623_13580	COG0531	amino acid
D9623_13660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9623_13695	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D9623_13705	COG2084	Dehydrogenase
D9623_13720	COG0840	transmembrane signaling receptor activity
D9623_13720	COG2972	Histidine kinase
D9623_13730	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D9623_13745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9623_13745	COG1199	ATP-dependent helicase activity
D9623_13750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9623_13760	COG2076	Multidrug Resistance protein
D9623_13765	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D9623_13780	COG0039	L-malate dehydrogenase activity
D9623_13785	COG0045	succinate-CoA ligase (ADP-forming) activity
D9623_13795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9623_13800	COG0045	succinate-CoA ligase (ADP-forming) activity
D9623_13815	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9623_13820	COG2205	protein histidine kinase activity
D9623_13825	COG3706	GGDEF domain
D9623_13830	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D9623_13845	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D9623_13895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D9623_13900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9623_13905	COG0552	protein localization to endoplasmic reticulum
D9623_13910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D9623_13920	COG2917	probably involved in intracellular septation
D9623_13935	COG0745	RESPONSE REGULATOR receiver
D9623_13940	COG2176	DNA-directed DNA polymerase activity
D9623_13940	COG5002	protein histidine kinase activity
D9623_13950	COG5002	protein histidine kinase activity
D9623_13965	COG0643	Histidine kinase
D9623_13965	COG2198	Histidine kinase
D9623_13970	COG0835	chemotaxis
D9623_13975	COG0840	transmembrane signaling receptor activity
D9623_13985	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D9623_13990	COG2201	protein-glutamate methylesterase activity
D9623_13995	COG0840	transmembrane signaling receptor activity
D9623_14000	COG1366	Belongs to the anti-sigma-factor antagonist family
D9623_14010	COG3706	GGDEF domain
D9623_14010	COG0745	RESPONSE REGULATOR receiver
D9623_14015	COG3706	GGDEF domain
D9623_14015	COG0745	RESPONSE REGULATOR receiver
D9623_14035	COG0745	RESPONSE REGULATOR receiver
D9623_14045	COG1366	Belongs to the anti-sigma-factor antagonist family
D9623_14050	COG4191	Histidine kinase
D9623_14075	COG0513	Belongs to the DEAD box helicase family
D9623_14095	COG0625	glutathione transferase activity
D9623_14105	COG0395	ABC-type sugar transport system, permease component
D9623_14125	COG0784	Response regulator, receiver
D9623_14125	COG2205	protein histidine kinase activity
D9623_14135	COG2814	Major facilitator Superfamily
D9623_14140	COG1285	pathogenesis
D9623_14170	COG2307	Protein conserved in bacteria
D9623_14170	COG2308	Evidence 4 Homologs of previously reported genes of
D9623_14175	COG2010	Cytochrome c
D9623_14195	COG2017	converts alpha-aldose to the beta-anomer
D9623_14200	COG2815	serine threonine protein kinase
D9623_14200	COG0515	serine threonine protein kinase
D9623_14205	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D9623_14235	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D9623_14245	COG0513	Belongs to the DEAD box helicase family
D9623_14255	COG0596	Alpha beta hydrolase
D9623_14265	COG0187	DNA topoisomerase II activity
D9623_14270	COG1607	acyl-coa hydrolase
D9623_14275	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D9623_14280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9623_14285	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9623_14285	COG0022	dehydrogenase e1 component
D9623_14290	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9623_14295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9623_14300	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D9623_14305	COG2867	negative regulation of translational initiation
D9623_14310	COG1058	Belongs to the CinA family
D9623_14310	COG1546	Belongs to the CinA family
D9623_14345	COG2204	response regulator
D9623_14355	COG0569	domain protein
D9623_14370	COG1923	regulation of RNA biosynthetic process
D9623_14375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D9623_14390	COG0483	inositol monophosphate 1-phosphatase activity
D9623_14405	COG3956	TIGRFAM MazG family protein
D9623_14410	COG3260	NADH ubiquinone oxidoreductase 20
D9623_14415	COG0649	NAD binding
D9623_14420	COG0651	ATP synthesis coupled electron transport
D9623_14430	COG0650	Formate hydrogenlyase subunit 4
D9623_14435	COG0651	ATP synthesis coupled electron transport
D9623_14445	COG2183	response to ionizing radiation
D9623_14455	COG1280	lysine exporter protein (LysE YggA)
D9623_14485	COG0393	Putative heavy-metal-binding
D9623_14490	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D9623_14505	COG4166	transmembrane transport
D9623_14510	COG0625	glutathione transferase activity
D9623_14515	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D9623_14520	COG0366	Alpha amylase catalytic
D9623_14540	COG0840	transmembrane signaling receptor activity
D9623_14575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_14585	COG0583	DNA-binding transcription factor activity
D9623_14590	COG4336	lyase activity
D9623_14605	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_14610	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D9623_14615	COG1984	allophanate hydrolase subunit 2
D9623_14620	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D9623_14630	COG4191	Histidine kinase
D9623_14635	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D9623_14645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D9623_14650	COG0058	SHG alpha-glucan phosphorylase activity
D9623_14705	COG5002	protein histidine kinase activity
D9623_14710	COG0745	RESPONSE REGULATOR receiver
D9623_14745	COG0719	Fe-S assembly protein
D9623_14750	COG0396	ATPase activity
D9623_14755	COG0719	Fe-S assembly protein
D9623_14760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D9623_14765	COG0822	iron-sulfur transferase activity
D9623_14775	COG0316	Belongs to the HesB IscA family
D9623_14785	COG0308	aminopeptidase N
D9623_14805	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D9623_14840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9623_14845	COG0697	spore germination
D9623_14855	COG2814	Major facilitator Superfamily
D9623_14860	COG0583	DNA-binding transcription factor activity
D9623_14875	COG3383	formate dehydrogenase (NAD+) activity
D9623_14880	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D9623_14895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9623_14900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9623_14920	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D9623_14930	COG0129	dihydroxy-acid dehydratase activity
D9623_14965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D9623_14970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D9623_14975	COG0534	Mate efflux family protein
D9623_15015	COG0629	single-stranded DNA binding
D9623_15020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D9623_15040	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D9623_15055	COG1562	ergosterol biosynthetic process
D9623_15060	COG1562	ergosterol biosynthetic process
D9623_15065	COG1233	COG1233 Phytoene dehydrogenase and related
D9623_15075	COG3737	Protein of unknown function (DUF498/DUF598)
D9623_15105	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D9623_15115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D9623_15120	COG3706	GGDEF domain
D9623_15120	COG0745	RESPONSE REGULATOR receiver
D9623_15125	COG0805	protein transport
D9623_15130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9623_15135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9623_15140	COG3842	ATPase activity
D9623_15145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D9623_15150	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D9623_15155	COG1994	Peptidase M50
D9623_15160	COG1472	Belongs to the glycosyl hydrolase 3 family
D9623_15175	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D9623_15180	COG0316	Belongs to the HesB IscA family
D9623_15185	COG0708	Exodeoxyribonuclease III
D9623_15200	COG3706	GGDEF domain
D9623_15200	COG0745	RESPONSE REGULATOR receiver
D9623_15205	COG0066	3-isopropylmalate dehydratase activity
D9623_15210	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D9623_15220	COG1335	isochorismatase
D9623_15255	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_15260	COG0683	leucine binding
D9623_15265	COG2188	Transcriptional regulator
D9623_15270	COG0717	Belongs to the dCTP deaminase family
D9623_15285	COG0730	response to heat
D9623_15290	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_15310	COG0303	'Molybdopterin
D9623_15315	COG0765	amino acid transport
D9623_15320	COG0765	amino acid transport
D9623_15330	COG1126	abc transporter atp-binding protein
D9623_15335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9623_15340	COG1609	Transcriptional regulator
D9623_15355	COG3265	gluconokinase activity
D9623_15360	COG1609	Transcriptional regulator
D9623_15365	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D9623_15370	COG1024	Enoyl-CoA hydratase
D9623_15380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9623_15385	COG1652	LysM domain
D9623_15395	COG1174	glycine betaine transport
D9623_15400	COG1125	glycine betaine transport
D9623_15405	COG1174	glycine betaine transport
D9623_15410	COG1732	Glycine betaine
D9623_15415	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D9623_15425	COG3842	ATPase activity
D9623_15435	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_15440	COG0581	inorganic phosphate transmembrane transporter activity
D9623_15475	COG0745	RESPONSE REGULATOR receiver
D9623_15480	COG2205	protein histidine kinase activity
D9623_15480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_15515	COG2814	Major facilitator Superfamily
D9623_15535	COG0758	DNA mediated transformation
D9623_15540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9623_15555	COG0179	Fumarylacetoacetate (FAA) hydrolase
D9623_15565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_15570	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_15575	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D9623_15580	COG1737	Transcriptional regulator
D9623_15580	COG0837	glucose binding
D9623_15585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9623_15595	COG0386	Belongs to the glutathione peroxidase family
D9623_15600	COG2814	Major facilitator Superfamily
D9623_15610	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D9623_15610	COG3264	Mechanosensitive ion channel
D9623_15660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9623_15665	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D9623_15675	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_15680	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D9623_15695	COG0437	4 iron, 4 sulfur cluster binding
D9623_15730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9623_15735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9623_15740	COG1845	cytochrome c oxidase, subunit III
D9623_15785	COG0601	transmembrane transport
D9623_15795	COG0444	Belongs to the ABC transporter superfamily
D9623_15820	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D9623_15825	COG1902	pentaerythritol trinitrate reductase activity
D9623_15825	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9623_15840	COG5564	TIM-barrel signal transduction protein
D9623_15840	COG2204	response regulator
D9623_15845	COG5441	Belongs to the UPF0261 family
D9623_15850	COG5564	TIM-barrel signal transduction protein
D9623_15880	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D9623_15905	COG0557	exoribonuclease II activity
D9623_15910	COG0793	Belongs to the peptidase S41A family
D9623_15915	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D9623_15920	COG0745	RESPONSE REGULATOR receiver
D9623_15920	COG3706	GGDEF domain
D9623_15930	COG2202	Pas domain
D9623_15930	COG2205	protein histidine kinase activity
D9623_15935	COG5002	protein histidine kinase activity
D9623_15935	COG5001	Diguanylate cyclase
D9623_15935	COG3447	MASE1 domain protein
D9623_15955	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D9623_15960	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D9623_15970	COG0248	Ppx GppA phosphatase
D9623_15975	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D9623_15985	COG3025	triphosphatase activity
D9623_15990	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_16000	COG0628	permease
D9623_16005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D9623_16015	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D9623_16020	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D9623_16035	COG0105	UTP biosynthetic process
D9623_16040	COG0488	(ABC) transporter
D9623_16045	COG3932	Exopolysaccharide synthesis, ExoD
D9623_16050	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D9623_16055	COG0300	oxidoreductase activity
D9623_16060	COG1561	YicC-like family, N-terminal region
D9623_16075	COG3328	transposase activity
D9623_16085	COG0519	Catalyzes the synthesis of GMP from XMP
D9623_16090	COG1247	-acetyltransferase
D9623_16115	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D9623_16125	COG3813	Protein conserved in bacteria
D9623_16145	COG0741	lytic transglycosylase activity
D9623_16160	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D9623_16165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9623_16175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D9623_16180	COG2927	DNA polymerase III (CHI subunit)
D9623_16185	COG2205	protein histidine kinase activity
D9623_16205	COG0556	nucleotide-excision repair
D9623_16220	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9623_16225	COG1846	Transcriptional regulator
D9623_16230	COG1278	Cold shock
D9623_16240	COG0745	RESPONSE REGULATOR receiver
D9623_16245	COG2205	protein histidine kinase activity
D9623_16255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_16280	COG0411	ABC transporter
D9623_16285	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_16385	COG3547	Transposase (IS116 IS110 IS902 family)
D9623_16425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9623_16430	COG1414	Transcriptional regulator
D9623_16435	COG2376	Dihydroxyacetone kinase
D9623_16455	COG1917	Cupin 2, conserved barrel domain protein
D9623_16455	COG4977	sequence-specific DNA binding
D9623_16470	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_16485	COG1063	alcohol dehydrogenase
D9623_16490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_16500	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_16505	COG2721	sulfolactate sulfo-lyase activity
D9623_16510	COG0246	Mannitol dehydrogenase
D9623_16535	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D9623_16540	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D9623_16545	COG0583	DNA-binding transcription factor activity
D9623_16550	COG2391	methyltransferase activity
D9623_16565	COG3842	ATPase activity
D9623_16570	COG4149	molybdate abc transporter
D9623_16575	COG1840	ABC-type Fe3 transport system, periplasmic component
D9623_16590	COG1686	Belongs to the peptidase S11 family
D9623_16635	COG1640	4-alpha-glucanotransferase
D9623_16650	COG0745	RESPONSE REGULATOR receiver
D9623_16665	COG0625	glutathione transferase activity
D9623_16670	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_16675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9623_16735	COG2099	Precorrin-6x reductase
D9623_16765	COG1797	cobyrinic acid a,c-diamide synthase activity
D9623_16770	COG0778	Nitroreductase
D9623_16775	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_16780	COG1309	transcriptional regulator
D9623_16785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9623_16790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9623_16795	COG0737	Belongs to the 5'-nucleotidase family
D9623_16820	COG1749	Flagellar hook protein flgE
D9623_16845	COG0795	lipopolysaccharide-transporting ATPase activity
D9623_16850	COG0840	transmembrane signaling receptor activity
D9623_16855	COG1137	ATPase activity
D9623_16865	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_16870	COG1376	ErfK ybiS ycfS ynhG family protein
D9623_16890	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9623_16925	COG2723	6-phospho-beta-galactosidase activity
D9623_16970	COG0154	amidase activity
D9623_16980	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9623_16990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9623_17005	COG0019	diaminopimelate decarboxylase activity
D9623_17025	COG0772	Belongs to the SEDS family
D9623_17035	COG0745	RESPONSE REGULATOR receiver
D9623_17055	COG1253	flavin adenine dinucleotide binding
D9623_17060	COG3932	Exopolysaccharide synthesis, ExoD
D9623_17065	COG2205	protein histidine kinase activity
D9623_17080	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D9623_17100	COG1657	PFAM Prenyltransferase squalene oxidase
D9623_17125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9623_17130	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D9623_17135	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D9623_17140	COG2080	2 iron, 2 sulfur cluster binding
D9623_17145	COG0583	DNA-binding transcription factor activity
D9623_17160	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D9623_17170	COG1960	acyl-CoA dehydrogenase activity
D9623_17225	COG0438	transferase activity, transferring glycosyl groups
D9623_17250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D9623_17260	COG0288	reversible hydration of carbon dioxide
D9623_17270	COG4948	Mandelate Racemase Muconate Lactonizing
D9623_17275	COG0583	DNA-binding transcription factor activity
D9623_17280	COG0625	glutathione transferase activity
D9623_17345	COG1335	isochorismatase
D9623_17350	COG4191	Histidine kinase
D9623_17355	COG4566	intracellular signal transduction
D9623_17395	COG0592	DNA-directed DNA polymerase activity
D9623_17400	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D9623_17405	COG0187	DNA topoisomerase II activity
D9623_17425	COG1132	(ABC) transporter
D9623_17440	COG1120	ATPase activity
D9623_17445	COG4774	siderophore transport
D9623_17455	COG0583	DNA-binding transcription factor activity
D9623_17460	COG2814	Major facilitator Superfamily
D9623_17500	COG0840	transmembrane signaling receptor activity
D9623_17540	COG0765	amino acid transport
D9623_17565	COG2879	small protein
D9623_17570	COG1966	Carbon starvation protein
D9623_17600	COG1609	Transcriptional regulator
D9623_17605	COG4221	oxidoreductase activity
D9623_17620	COG1024	Enoyl-CoA hydratase
D9623_17640	COG1175	transmembrane transport
D9623_17650	COG3842	ATPase activity
D9623_17680	COG0683	leucine binding
D9623_17715	COG4615	Cyclic peptide transporter
D9623_17755	COG1320	monovalent cation:proton antiporter activity
D9623_17760	COG2212	antiporter activity
D9623_17765	COG1863	multisubunit Na H antiporter MnhE subunit
D9623_17770	COG0651	ATP synthesis coupled electron transport
D9623_17775	COG1006	Multisubunit Na H antiporter MnhC subunit
D9623_17780	COG2111	Na H antiporter
D9623_17780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D9623_17790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9623_17795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D9623_17800	COG2091	lysine biosynthetic process via aminoadipic acid
D9623_17810	COG2027	D-alanyl-D-alanine carboxypeptidase
D9623_17840	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D9623_17850	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9623_17860	COG0840	transmembrane signaling receptor activity
D9623_17875	COG0745	RESPONSE REGULATOR receiver
D9623_17880	COG2205	protein histidine kinase activity
D9623_17885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D9623_17890	COG2864	formate dehydrogenase
D9623_17895	COG0437	4 iron, 4 sulfur cluster binding
D9623_17900	COG3383	formate dehydrogenase (NAD+) activity
D9623_17900	COG0243	molybdopterin cofactor binding
D9623_17920	COG0235	Class ii aldolase
D9623_17925	COG1942	4-Oxalocrotonate Tautomerase
D9623_17955	COG0420	3'-5' exonuclease activity
D9623_17965	COG3591	Belongs to the peptidase S1B family
D9623_17975	COG1192	Involved in chromosome partitioning
D9623_17980	COG1475	DNA binding
D9623_17995	COG0583	DNA-binding transcription factor activity
D9623_18000	COG0251	oxidation-reduction process
D9623_18015	COG3707	response regulator
D9623_18020	COG1116	anion transmembrane transporter activity
D9623_18030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9623_18035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9623_18040	COG2146	nitrite reductase [NAD(P)H] activity
D9623_18045	COG0243	molybdopterin cofactor binding
D9623_18050	COG1648	precorrin-2 dehydrogenase activity
D9623_18050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D9623_18055	COG0791	NLP P60 protein
D9623_18065	COG1032	radical SAM domain protein
D9623_18115	COG1609	Transcriptional regulator
D9623_18120	COG0583	DNA-binding transcription factor activity
D9623_18135	COG3195	allantoin biosynthetic process
D9623_18135	COG3648	Uricase
D9623_18145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_18165	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D9623_18205	COG3383	formate dehydrogenase (NAD+) activity
D9623_18205	COG0243	molybdopterin cofactor binding
D9623_18210	COG0437	4 iron, 4 sulfur cluster binding
D9623_18215	COG2864	formate dehydrogenase
D9623_18220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_18245	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_18255	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_18285	COG0745	RESPONSE REGULATOR receiver
D9623_18290	COG0642	Histidine kinase
D9623_18290	COG3850	Histidine kinase
D9623_18340	COG2223	nitrite transmembrane transporter activity
D9623_18375	COG1137	ATPase activity
D9623_18380	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D9623_18385	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D9623_18390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9623_18395	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9623_18400	COG0527	aspartate kinase activity
D9623_18405	COG2070	2-Nitropropane dioxygenase
D9623_18420	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D9623_18425	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D9623_18435	COG2852	Protein conserved in bacteria
D9623_18440	COG2890	protein-(glutamine-N5) methyltransferase activity
D9623_18460	COG0542	response to heat
D9623_18465	COG1272	protein, Hemolysin III
D9623_18470	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D9623_18485	COG0840	transmembrane signaling receptor activity
D9623_18490	COG5265	(ABC) transporter
D9623_18500	COG1703	isobutyryl-CoA mutase activity
D9623_18510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D9623_18520	COG2137	regulation of response to DNA damage stimulus
D9623_18525	COG0842	Transport permease protein
D9623_18530	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D9623_18535	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D9623_18540	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D9623_18550	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D9623_18555	COG0671	phosphoesterase, PA-phosphatase related
D9623_18570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D9623_18575	COG4774	siderophore transport
D9623_18580	COG3128	pkhd-type hydroxylase
D9623_18600	COG4604	ABC transporter, ATP-binding protein
D9623_18605	COG4605	iron ion homeostasis
D9623_18610	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9623_18615	COG4607	ABC-type enterochelin transport system periplasmic component
D9623_18620	COG1695	Transcriptional regulator
D9623_18635	COG2205	protein histidine kinase activity
D9623_18635	COG0784	Response regulator, receiver
D9623_18635	COG5002	protein histidine kinase activity
D9623_18695	COG4206	TonB-dependent receptor
D9623_18745	COG3685	Protein conserved in bacteria
D9623_18780	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D9623_18790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9623_18795	COG1959	2 iron, 2 sulfur cluster binding
D9623_18805	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D9623_18815	COG4208	sulfate ABC transporter
D9623_18820	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D9623_18855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D9623_18860	COG0367	asparagine synthase
D9623_18865	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_18885	COG0438	transferase activity, transferring glycosyl groups
D9623_18890	COG0438	transferase activity, transferring glycosyl groups
D9623_18895	COG1215	transferase activity, transferring glycosyl groups
D9623_18920	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D9623_18930	COG3693	PFAM glycoside hydrolase, family 10
D9623_18940	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D9623_18950	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D9623_18955	COG0588	phosphoglycerate mutase activity
D9623_18980	COG5002	protein histidine kinase activity
D9623_18995	COG2011	ABC-type metal ion transport system permease component
D9623_19000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D9623_19005	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_19010	COG1464	Belongs to the NlpA lipoprotein family
D9623_19025	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D9623_19035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D9623_19050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D9623_19060	COG1530	ribonuclease E activity
D9623_19065	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D9623_19095	COG1192	Involved in chromosome partitioning
D9623_19100	COG1522	sequence-specific DNA binding
D9623_19110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D9623_19125	COG1309	transcriptional regulator
D9623_19140	COG5507	3-demethylubiquinone-9 3-methyltransferase
D9623_19150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D9623_19160	COG1917	Cupin 2, conserved barrel domain protein
D9623_19160	COG1396	sequence-specific DNA binding
D9623_19170	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_19175	COG2182	Extracellular solute-binding protein
D9623_19180	COG3842	ATPase activity
D9623_19185	COG0583	DNA-binding transcription factor activity
D9623_19195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9623_19225	COG0471	metal ion transport
D9623_19225	COG3273	potassium ion transport
D9623_19235	COG2814	Major facilitator Superfamily
D9623_19240	COG0583	DNA-binding transcription factor activity
D9623_19250	COG1566	PFAM secretion protein HlyD family protein
D9623_19295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9623_19310	COG0789	Transcriptional regulator
D9623_19315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9623_19325	COG2860	membrane
D9623_19330	COG1741	Belongs to the pirin family
D9623_19355	COG2217	Heavy metal translocating P-type atpase
D9623_19370	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D9623_19385	COG0521	Mo-molybdopterin cofactor biosynthetic process
D9623_19390	COG0741	lytic transglycosylase activity
D9623_19395	COG1573	uracil-dna glycosylase
D9623_19420	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_19535	COG0583	DNA-binding transcription factor activity
D9623_19545	COG1283	sodium-dependent phosphate transmembrane transporter activity
D9623_19570	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_19605	COG0306	phosphate transporter
D9623_19610	COG1392	Phosphate transport regulator
D9623_19620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9623_19630	COG2223	nitrite transmembrane transporter activity
D9623_19665	COG0612	Peptidase, M16
D9623_19675	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D9623_19695	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D9623_19705	COG0488	(ABC) transporter
D9623_19720	COG2249	NAD(P)H dehydrogenase (quinone) activity
D9623_19725	COG0583	DNA-binding transcription factor activity
D9623_19730	COG3135	benzoate transporter
D9623_19740	COG0505	Belongs to the CarA family
D9623_19745	COG0586	Pfam SNARE associated Golgi protein
D9623_19780	COG2884	Cell division ATP-binding protein ftsE
D9623_19790	COG1309	transcriptional regulator
D9623_19815	COG5001	Diguanylate cyclase
D9623_19820	COG1381	Involved in DNA repair and RecF pathway recombination
D9623_19825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D9623_19830	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D9623_19835	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_19845	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D9623_19855	COG2308	Evidence 4 Homologs of previously reported genes of
D9623_19860	COG1360	Flagellar Motor Protein
D9623_19865	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D9623_19870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9623_19895	COG0643	Histidine kinase
D9623_19895	COG2198	Histidine kinase
D9623_19900	COG0835	chemotaxis
D9623_19905	COG2201	protein-glutamate methylesterase activity
D9623_19920	COG0583	DNA-binding transcription factor activity
D9623_19930	COG0745	RESPONSE REGULATOR receiver
D9623_19935	COG1157	protein secretion by the type III secretion system
D9623_19950	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D9623_19960	COG0455	bacterial-type flagellum organization
D9623_19965	COG0552	protein localization to endoplasmic reticulum
D9623_19970	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9623_19975	COG2204	response regulator
D9623_19980	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9623_19985	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9623_19995	COG1766	The M ring may be actively involved in energy transduction
D9623_20000	COG1396	sequence-specific DNA binding
D9623_20010	COG2205	protein histidine kinase activity
D9623_20015	COG2373	Large extracellular alpha-helical protein
D9623_20030	COG0183	Belongs to the thiolase family
D9623_20035	COG1024	Enoyl-CoA hydratase
D9623_20035	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9623_20040	COG1960	acyl-CoA dehydrogenase activity
D9623_20055	COG3047	cAMP biosynthetic process
D9623_20070	COG1196	nuclear chromosome segregation
D9623_20085	COG1194	a g-specific adenine glycosylase
D9623_20105	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D9623_20115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9623_20115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_20120	COG3012	SEC-C Motif Domain Protein
D9623_20130	COG0793	Belongs to the peptidase S41A family
D9623_20140	COG0309	Hydrogenase expression formation protein (HypE)
D9623_20145	COG0298	carbon dioxide binding
D9623_20150	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D9623_20155	COG1280	lysine exporter protein (LysE YggA)
D9623_20165	COG0375	protein maturation
D9623_20180	COG0298	carbon dioxide binding
D9623_20200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D9623_20205	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D9623_20210	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D9623_20215	COG5557	Pfam Polysulphide reductase, NrfD
D9623_20220	COG0437	4 iron, 4 sulfur cluster binding
D9623_20225	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D9623_20240	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D9623_20270	COG0625	glutathione transferase activity
D9623_20275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9623_20295	COG2813	Specifically methylates the guanine in position
D9623_20295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D9623_20300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D9623_20310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D9623_20315	COG0287	Prephenate dehydrogenase
D9623_20320	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D9623_20330	COG0583	DNA-binding transcription factor activity
D9623_20335	COG0450	alkyl hydroperoxide reductase
D9623_20340	COG3634	alkyl hydroperoxide reductase activity
D9623_20345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D9623_20350	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D9623_20355	COG2080	2 iron, 2 sulfur cluster binding
D9623_20365	COG1988	membrane-bound metal-dependent
D9623_20385	COG0745	RESPONSE REGULATOR receiver
D9623_20390	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D9623_20395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9623_20400	COG0540	Belongs to the ATCase OTCase family
D9623_20415	COG0583	DNA-binding transcription factor activity
D9623_20445	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D9623_20455	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D9623_20460	COG0154	amidase activity
D9623_20465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D9623_20470	COG4191	Histidine kinase
D9623_20500	COG1794	racemase activity, acting on amino acids and derivatives
D9623_20510	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D9623_20520	COG1268	BioY protein
D9623_20540	COG2204	response regulator
D9623_20545	COG4191	Histidine kinase
D9623_20550	COG1301	dicarboxylic acid transport
D9623_20555	COG0280	phosphate acetyltransferase
D9623_20555	COG0281	malic enzyme
D9623_20560	COG0859	PFAM glycosyl transferase family 9
D9623_20560	COG0457	Tetratricopeptide repeat
D9623_20570	COG2995	paraquat-inducible protein a
D9623_20575	COG3008	intermembrane lipid transfer
D9623_20575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D9623_20585	COG1882	Formate acetyltransferase
D9623_20595	COG0277	FAD linked oxidase domain protein
D9623_20610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9623_20625	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D9623_20630	COG0567	Dehydrogenase, E1 component
D9623_20650	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D9623_20755	COG0714	Associated with various cellular activities
D9623_20775	COG0617	tRNA 3'-terminal CCA addition
D9623_20780	COG0408	coproporphyrinogen oxidase activity
D9623_20785	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D9623_20800	COG2857	Cytochrome c1
D9623_20800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D9623_20820	COG0640	Transcriptional regulator
D9623_20830	COG0425	Belongs to the sulfur carrier protein TusA family
D9623_20850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D9623_20860	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D9623_20875	COG0583	DNA-binding transcription factor activity
D9623_20885	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_20890	COG1846	Transcriptional regulator
D9623_20910	COG0583	DNA-binding transcription factor activity
D9623_20925	COG0300	oxidoreductase activity
D9623_20960	COG1396	sequence-specific DNA binding
D9623_20975	COG3284	Transcriptional regulator
D9623_20980	COG3199	ATP-NAD kinase
D9623_20985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9623_20990	COG0022	dehydrogenase e1 component
D9623_20995	COG0596	Alpha beta hydrolase
D9623_20995	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9623_21005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D9623_21015	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_21020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_21040	COG1082	Xylose isomerase domain protein TIM barrel
D9623_21050	COG0183	Belongs to the thiolase family
D9623_21090	COG1595	DNA-templated transcription, initiation
D9623_21095	COG3806	Anti-sigma factor
D9623_21100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9623_21120	COG3501	Rhs element vgr protein
D9623_21230	COG2862	Uncharacterized protein family, UPF0114
D9623_21260	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D9623_21345	COG0583	DNA-binding transcription factor activity
D9623_21365	COG0667	Aldo Keto reductase
D9623_21370	COG0583	DNA-binding transcription factor activity
D9623_21425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9623_21430	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D9623_21435	COG1127	ABC transporter
D9623_21455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9623_21460	COG1271	oxidase subunit
D9623_21465	COG1294	oxidase, subunit
D9623_21495	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_21520	COG2089	acid synthase
D9623_21525	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D9623_21555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9623_21570	COG2703	oxygen carrier activity
D9623_21575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9623_21605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D9623_21615	COG2030	dehydratase
D9623_21620	COG0196	riboflavin kinase activity
D9623_21625	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D9623_21630	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D9623_21640	COG0859	PFAM glycosyl transferase family 9
D9623_21640	COG0457	Tetratricopeptide repeat
D9623_21645	COG0457	Tetratricopeptide repeat
D9623_21645	COG0859	PFAM glycosyl transferase family 9
D9623_21660	COG0859	PFAM glycosyl transferase family 9
D9623_21660	COG0457	Tetratricopeptide repeat
D9623_21680	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9623_21710	COG0784	Response regulator, receiver
D9623_21740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D9623_21750	COG1228	amidohydrolase
D9623_21765	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D9623_21780	COG2226	methyltransferase
D9623_21795	COG0747	negative chemotaxis
D9623_21800	COG0601	transmembrane transport
D9623_21805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_21810	COG0444	Belongs to the ABC transporter superfamily
D9623_21815	COG4608	Belongs to the ABC transporter superfamily
D9623_21850	COG1666	GTP binding
D9623_21870	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9623_21875	COG5001	Diguanylate cyclase
D9623_21905	COG1752	Esterase of the alpha-beta hydrolase superfamily
D9623_21910	COG1132	(ABC) transporter
D9623_21915	COG4191	Histidine kinase
D9623_21940	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D9623_21950	COG2264	protein methyltransferase activity
D9623_21955	COG0583	DNA-binding transcription factor activity
D9623_21960	COG0655	NAD(P)H dehydrogenase (quinone) activity
D9623_21965	COG0435	Glutathione S-transferase
D9623_21975	COG2197	response regulator
D9623_21985	COG0492	ferredoxin-NADP+ reductase activity
D9623_22015	COG0501	Belongs to the peptidase M48B family
D9623_22025	COG3038	cytochrome b561
D9623_22030	COG3240	lipase activity
D9623_22045	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9623_22055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D9623_22065	COG1846	Transcriptional regulator
D9623_22075	COG3920	Histidine kinase
D9623_22090	COG1758	RNA polymerase activity
D9623_22105	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D9623_22110	COG0736	holo-[acyl-carrier-protein] synthase activity
D9623_22115	COG0681	Belongs to the peptidase S26 family
D9623_22120	COG0571	ribonuclease III activity
D9623_22125	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D9623_22130	COG3106	COG3106 Predicted ATPase
D9623_22135	COG3768	UPF0283 membrane protein
D9623_22155	COG0740	serine-type endopeptidase activity
D9623_22160	COG1216	Glycosyl transferase, family 2
D9623_22165	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D9623_22170	COG1566	PFAM secretion protein HlyD family protein
D9623_22175	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_22185	COG0183	Belongs to the thiolase family
D9623_22190	COG1960	acyl-CoA dehydrogenase activity
D9623_22200	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_22220	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_22235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9623_22240	COG0747	negative chemotaxis
D9623_22250	COG2201	protein-glutamate methylesterase activity
D9623_22270	COG4771	TonB-dependent receptor
D9623_22295	COG1169	isochorismate synthase
D9623_22300	COG1021	2,3-dihydroxybenzoate-AMP ligase
D9623_22305	COG1535	isochorismatase
D9623_22305	COG3433	isochorismatase activity
D9623_22310	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_22320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9623_22325	COG2382	esterase
D9623_22335	COG1960	acyl-CoA dehydrogenase activity
D9623_22340	COG2186	Transcriptional regulator
D9623_22345	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_22350	COG1309	transcriptional regulator
D9623_22360	COG1846	Transcriptional regulator
D9623_22365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D9623_22375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_22395	COG2226	methyltransferase
D9623_22460	COG0861	Integral membrane protein TerC family
D9623_22470	COG2239	Acts as a magnesium transporter
D9623_22475	COG1802	Transcriptional regulator
D9623_22515	COG0367	asparagine synthase
D9623_22520	COG1181	Belongs to the D-alanine--D-alanine ligase family
D9623_22520	COG2918	glutathione biosynthetic process
D9623_22525	COG1363	Peptidase, m42
D9623_22535	COG1966	Carbon starvation protein
D9623_22545	COG3275	phosphorelay sensor kinase activity
D9623_22585	COG0848	biopolymer transport protein
D9623_22595	COG4566	intracellular signal transduction
D9623_22600	COG4191	Histidine kinase
D9623_22605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D9623_22640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_22650	COG5002	protein histidine kinase activity
D9623_22650	COG0784	Response regulator, receiver
D9623_22650	COG2205	protein histidine kinase activity
D9623_22675	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_22680	COG2890	protein-(glutamine-N5) methyltransferase activity
D9623_22700	COG0542	response to heat
D9623_22710	COG0402	S-adenosylhomocysteine deaminase activity
D9623_22715	COG1116	anion transmembrane transporter activity
D9623_22720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_22740	COG3842	ATPase activity
D9623_22745	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D9623_22750	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_22760	COG2351	hydroxyisourate hydrolase activity
D9623_22770	COG0154	amidase activity
D9623_22775	COG0784	Response regulator, receiver
D9623_22775	COG5002	protein histidine kinase activity
D9623_22810	COG3387	PFAM Glycoside hydrolase 15-related
D9623_22820	COG2197	response regulator
D9623_22825	COG2197	response regulator
D9623_22840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D9623_22845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9623_22850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9623_22855	COG0438	transferase activity, transferring glycosyl groups
D9623_22875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9623_22895	COG0438	transferase activity, transferring glycosyl groups
D9623_22910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D9623_22925	COG0583	DNA-binding transcription factor activity
D9623_22930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_22945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_22950	COG4172	Belongs to the ABC transporter superfamily
D9623_22970	COG0028	Belongs to the TPP enzyme family
D9623_22975	COG3246	L-lysine catabolic process to acetate
D9623_22995	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_23000	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_23010	COG1850	ribulose-bisphosphate carboxylase activity
D9623_23020	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_23025	COG2204	response regulator
D9623_23080	COG4459	periplasmic nitrate reductase
D9623_23105	COG3005	denitrification pathway
D9623_23140	COG1845	cytochrome c oxidase, subunit III
D9623_23145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9623_23150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9623_23155	COG0477	Major facilitator Superfamily
D9623_23165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D9623_23170	COG0406	alpha-ribazole phosphatase activity
D9623_23170	COG0328	RNA-DNA hybrid ribonuclease activity
D9623_23195	COG0392	lysyltransferase activity
D9623_23200	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D9623_23255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D9623_23275	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D9623_23280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_23300	COG1846	Transcriptional regulator
D9623_23305	COG1764	response to oxidative stress
D9623_23325	COG2113	Glycine betaine
D9623_23330	COG4176	ABC-type proline glycine betaine transport system permease component
D9623_23335	COG4175	Glycine betaine
D9623_23340	COG0339	signal peptide processing
D9623_23365	COG1522	sequence-specific DNA binding
D9623_23370	COG0251	oxidation-reduction process
D9623_23375	COG4336	lyase activity
D9623_23380	COG0405	Gamma-glutamyltransferase
D9623_23385	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9623_23390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_23415	COG1595	DNA-templated transcription, initiation
D9623_23420	COG4774	siderophore transport
D9623_23435	COG4774	siderophore transport
D9623_23455	COG1120	ATPase activity
D9623_23485	COG0431	NADPH-dependent FMN reductase
D9623_23490	COG0798	PFAM Bile acid sodium symporter
D9623_23520	COG3842	ATPase activity
D9623_23530	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_23540	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_23545	COG1024	Enoyl-CoA hydratase
D9623_23550	COG0604	alcohol dehydrogenase
D9623_23570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_23625	COG0840	transmembrane signaling receptor activity
D9623_23630	COG4178	(ABC) transporter
D9623_23640	COG1475	DNA binding
D9623_23645	COG1192	Involved in chromosome partitioning
D9623_23650	COG4783	chaperone-mediated protein folding
D9623_23670	COG3622	Belongs to the hyi family
D9623_23680	COG1215	transferase activity, transferring glycosyl groups
D9623_23695	COG3307	-O-antigen
D9623_23700	COG3206	protein involved in exopolysaccharide biosynthesis
D9623_23700	COG0489	protein tyrosine kinase activity
D9623_23730	COG1216	Glycosyl transferase, family 2
D9623_23800	COG0640	Transcriptional regulator
D9623_23805	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9623_23825	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9623_23835	COG4566	intracellular signal transduction
D9623_23850	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_23870	COG0517	IMP dehydrogenase activity
D9623_23870	COG1994	Peptidase M50
D9623_23880	COG1959	2 iron, 2 sulfur cluster binding
D9623_23890	COG1522	sequence-specific DNA binding
D9623_23905	COG0583	DNA-binding transcription factor activity
D9623_23910	COG1802	Transcriptional regulator
D9623_23915	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_23925	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_23930	COG2354	Protein conserved in bacteria
D9623_23950	COG1418	mRNA catabolic process
D9623_23955	COG1131	(ABC) transporter
D9623_23960	COG0842	Transport permease protein
D9623_23965	COG3791	Glutathione-dependent formaldehyde-activating
D9623_23970	COG0154	amidase activity
D9623_23975	COG0154	amidase activity
D9623_23980	COG1335	isochorismatase
D9623_23985	COG0747	negative chemotaxis
D9623_24005	COG4608	Belongs to the ABC transporter superfamily
D9623_24010	COG1335	isochorismatase
D9623_24015	COG3180	Ammonia monooxygenase
D9623_24020	COG1802	Transcriptional regulator
D9623_24030	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D9623_24035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D9623_24040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D9623_24045	COG2205	protein histidine kinase activity
D9623_24070	COG0840	transmembrane signaling receptor activity
D9623_24075	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_24080	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_24085	COG3842	ATPase activity
D9623_24095	COG1024	Enoyl-CoA hydratase
D9623_24100	COG1414	Transcriptional regulator
D9623_24155	COG0583	DNA-binding transcription factor activity
D9623_24165	COG1396	sequence-specific DNA binding
D9623_24165	COG3800	Transcriptional regulator
D9623_24175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9623_24195	COG2828	Protein conserved in bacteria
D9623_24280	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
D9623_24290	COG0189	ligase activity
D9623_24295	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
D9623_24305	COG0702	epimerase
D9623_24315	COG2154	pterin-4-alpha-carbinolamine dehydratase
D9623_24325	COG1229	Formylmethanofuran dehydrogenase subunit A
D9623_24330	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
D9623_24350	COG1131	(ABC) transporter
D9623_24410	COG2010	Cytochrome c
D9623_24435	COG1573	uracil-dna glycosylase
D9623_24455	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D9623_24465	COG0583	DNA-binding transcription factor activity
D9623_24490	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_24535	COG1764	response to oxidative stress
D9623_24540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9623_24545	COG1960	acyl-CoA dehydrogenase activity
D9623_24550	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D9623_24625	COG0668	transmembrane transport
D9623_24665	COG1139	Iron-sulfur cluster binding protein
D9623_24670	COG0247	lactate metabolic process
D9623_24675	COG0277	FAD linked oxidase domain protein
D9623_24680	COG1620	l-lactate permease
D9623_24685	COG2186	Transcriptional regulator
D9623_24695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D9623_24700	COG0542	response to heat
D9623_24705	COG1414	Transcriptional regulator
D9623_24710	COG3734	2-keto-3-deoxy-galactonokinase
D9623_24715	COG0800	Aldolase
D9623_24745	COG0861	Integral membrane protein TerC family
D9623_24755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_24760	COG2353	YceI-like domain
D9623_24780	COG4566	intracellular signal transduction
D9623_24785	COG4566	intracellular signal transduction
D9623_24790	COG4191	Histidine kinase
D9623_24800	COG1538	Outer membrane efflux protein
D9623_24805	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_24810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_24815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_24825	COG0427	acetyl-CoA hydrolase
D9623_24850	COG0243	molybdopterin cofactor binding
D9623_24940	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D9623_24950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_24955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_24965	COG0628	permease
D9623_24970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D9623_24980	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D9623_25010	COG1192	Involved in chromosome partitioning
D9623_25020	COG1653	transport
D9623_25035	COG3842	ATPase activity
D9623_25060	COG0840	transmembrane signaling receptor activity
D9623_25060	COG0840	transmembrane signaling receptor activity
D9623_25075	COG0411	ABC transporter
D9623_25085	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_25100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_25105	COG1473	amidohydrolase
D9623_25150	COG1971	Probably functions as a manganese efflux pump
D9623_25155	COG0840	transmembrane signaling receptor activity
D9623_25155	COG3290	protein histidine kinase activity
D9623_25180	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_25185	COG0366	Alpha amylase catalytic
D9623_25190	COG2388	GCN5-related N-acetyl-transferase
D9623_25205	COG4191	Histidine kinase
D9623_25205	COG0784	Response regulator, receiver
D9623_25210	COG0784	Response regulator, receiver
D9623_25210	COG5002	protein histidine kinase activity
D9623_25235	COG0840	transmembrane signaling receptor activity
D9623_25270	COG4615	Cyclic peptide transporter
D9623_25290	COG0586	Pfam SNARE associated Golgi protein
D9623_25305	COG3842	ATPase activity
D9623_25315	COG0395	ABC-type sugar transport system, permease component
D9623_25330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D9623_25335	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_25360	COG2095	MarC family integral membrane protein
D9623_25375	COG0840	transmembrane signaling receptor activity
D9623_25380	COG0835	chemotaxis
D9623_25385	COG2201	protein-glutamate methylesterase activity
D9623_25395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9623_25400	COG3706	GGDEF domain
D9623_25400	COG0745	RESPONSE REGULATOR receiver
D9623_25405	COG0643	Histidine kinase
D9623_25405	COG2198	Histidine kinase
D9623_25415	COG2197	response regulator
D9623_25430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_25440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9623_25470	COG2204	response regulator
D9623_25480	COG2985	domain, Protein
D9623_25495	COG3842	ATPase activity
D9623_25510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_25520	COG0251	oxidation-reduction process
D9623_25540	COG0747	negative chemotaxis
D9623_25550	COG0583	DNA-binding transcription factor activity
D9623_25560	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9623_25565	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9623_25565	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9623_25570	COG1660	Displays ATPase and GTPase activities
D9623_25585	COG0642	Histidine kinase
D9623_25590	COG0745	RESPONSE REGULATOR receiver
D9623_25605	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D9623_25620	COG0739	heme binding
D9623_25645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9623_25665	COG1216	Glycosyl transferase, family 2
D9623_25665	COG1442	glycosyl transferase family 8
D9623_25675	COG4178	(ABC) transporter
D9623_25685	COG2723	6-phospho-beta-galactosidase activity
D9623_25690	COG2723	6-phospho-beta-galactosidase activity
D9623_25710	COG2819	hydrolase of the alpha beta superfamily
D9623_25745	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D9623_25750	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D9623_25755	COG1960	acyl-CoA dehydrogenase activity
D9623_25765	COG0604	alcohol dehydrogenase
D9623_25770	COG1024	Enoyl-CoA hydratase
D9623_25775	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_25785	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_25795	COG3842	ATPase activity
D9623_25825	COG0798	PFAM Bile acid sodium symporter
D9623_25830	COG0431	NADPH-dependent FMN reductase
D9623_25860	COG1120	ATPase activity
D9623_25880	COG4774	siderophore transport
D9623_25895	COG4774	siderophore transport
D9623_25900	COG1595	DNA-templated transcription, initiation
D9623_25925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_25930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9623_25935	COG0405	Gamma-glutamyltransferase
D9623_25940	COG4336	lyase activity
D9623_25945	COG0251	oxidation-reduction process
D9623_25950	COG1522	sequence-specific DNA binding
D9623_25990	COG1749	Flagellar hook protein flgE
D9623_25995	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D9623_26010	COG0667	Aldo Keto reductase
D9623_26030	COG4772	TonB-dependent receptor
D9623_26055	COG4251	negative regulation of phosphorylation
D9623_26060	COG0745	RESPONSE REGULATOR receiver
D9623_26065	COG0745	RESPONSE REGULATOR receiver
D9623_26080	COG2080	2 iron, 2 sulfur cluster binding
D9623_26085	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D9623_26090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D9623_26100	COG2814	Major facilitator Superfamily
D9623_26115	COG0583	DNA-binding transcription factor activity
D9623_26155	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9623_26160	COG1024	Enoyl-CoA hydratase
D9623_26165	COG0022	dehydrogenase e1 component
D9623_26165	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9623_26170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D9623_26180	COG0683	leucine binding
D9623_26185	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_26195	COG0410	ABC transporter
D9623_26210	COG4221	oxidoreductase activity
D9623_26215	COG2814	Major facilitator Superfamily
D9623_26230	COG4774	siderophore transport
D9623_26245	COG1802	Transcriptional regulator
D9623_26250	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_26255	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D9623_26260	COG4948	Mandelate Racemase Muconate Lactonizing
D9623_26265	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_26275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D9623_26295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9623_26300	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_26305	COG3842	ATPase activity
D9623_26315	COG0277	FAD linked oxidase domain protein
D9623_26325	COG0842	Transport permease protein
D9623_26330	COG1129	ABC transporter
D9623_26330	COG0842	Transport permease protein
D9623_26335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_26340	COG1940	carbohydrate kinase activity
D9623_26350	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9623_26355	COG1879	ABC-type sugar transport system periplasmic component
D9623_26365	COG0673	inositol 2-dehydrogenase activity
D9623_26370	COG2115	Belongs to the xylose isomerase family
D9623_26375	COG1070	Carbohydrate kinase
D9623_26380	COG0583	DNA-binding transcription factor activity
D9623_26390	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D9623_26390	COG1017	nitric oxide dioxygenase activity
D9623_26395	COG0625	glutathione transferase activity
D9623_26400	COG1802	Transcriptional regulator
D9623_26405	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_26425	COG1012	belongs to the aldehyde dehydrogenase family
D9623_26430	COG1024	Enoyl-CoA hydratase
D9623_26435	COG2186	Transcriptional regulator
D9623_26535	COG1136	(ABC) transporter
D9623_26535	COG0577	efflux transmembrane transporter activity
D9623_26540	COG1136	(ABC) transporter
D9623_26540	COG0577	efflux transmembrane transporter activity
D9623_26560	COG0523	cobalamin synthesis protein
D9623_26585	COG4977	sequence-specific DNA binding
D9623_26895	COG3772	lysozyme
D9623_27005	COG2814	Major facilitator Superfamily
D9623_27010	COG0683	leucine binding
D9623_27025	COG0411	ABC transporter
D9623_27040	COG4566	intracellular signal transduction
D9623_27040	COG0745	RESPONSE REGULATOR receiver
D9623_27050	COG1278	Cold shock
D9623_27055	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D9623_27060	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D9623_27075	COG2204	response regulator
D9623_27080	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9623_27085	COG3246	L-lysine catabolic process to acetate
D9623_27090	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_27100	COG1396	sequence-specific DNA binding
D9623_27105	COG1304	FMN binding
D9623_27120	COG3842	ATPase activity
D9623_27125	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_27130	COG1177	transmembrane transport
D9623_27150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_27155	COG0251	oxidation-reduction process
D9623_27165	COG0251	oxidation-reduction process
D9623_27170	COG0861	Integral membrane protein TerC family
D9623_27195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_27200	COG3250	beta-galactosidase activity
D9623_27225	COG1783	phage Terminase large subunit
D9623_27300	COG2205	protein histidine kinase activity
D9623_27300	COG5002	protein histidine kinase activity
D9623_27300	COG0784	Response regulator, receiver
D9623_27315	COG1695	Transcriptional regulator
D9623_27320	COG4607	ABC-type enterochelin transport system periplasmic component
D9623_27325	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9623_27330	COG4605	iron ion homeostasis
D9623_27335	COG4604	ABC transporter, ATP-binding protein
D9623_27380	COG4302	ethanolamine ammonia-lyase activity
D9623_27405	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9623_27405	COG0515	serine threonine protein kinase
D9623_27415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_27420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_27435	COG0066	3-isopropylmalate dehydratase activity
D9623_27440	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D9623_27445	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D9623_27450	COG1802	Transcriptional regulator
D9623_27455	COG3938	Belongs to the proline racemase family
D9623_27460	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_27465	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_27470	COG3842	ATPase activity
D9623_27475	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D9623_27525	COG3436	PFAM IS66 Orf2 family protein
D9623_27575	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_27580	COG0583	DNA-binding transcription factor activity
D9623_27585	COG1846	Transcriptional regulator
D9623_27590	COG1764	response to oxidative stress
D9623_27695	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D9623_27720	COG1595	DNA-templated transcription, initiation
D9623_27725	COG3712	iron ion homeostasis
D9623_27735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_27740	COG0577	efflux transmembrane transporter activity
D9623_27740	COG1136	(ABC) transporter
D9623_27755	COG1121	(ABC) transporter
D9623_27785	COG2188	Transcriptional regulator
D9623_27800	COG0697	spore germination
D9623_27815	COG1595	DNA-templated transcription, initiation
D9623_27835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9623_27855	COG0154	amidase activity
D9623_27860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9623_27865	COG1024	Enoyl-CoA hydratase
D9623_27875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9623_27890	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_27930	COG1959	2 iron, 2 sulfur cluster binding
D9623_28065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D9623_28070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9623_28100	COG0633	Ferredoxin
D9623_28105	COG2124	cytochrome p450
D9623_28120	COG0583	DNA-binding transcription factor activity
D9623_28150	COG2271	Major facilitator Superfamily
D9623_28160	COG0583	DNA-binding transcription factor activity
D9623_28190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_28230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9623_28245	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D9623_28260	COG4263	nitrous-oxide reductase activity
D9623_28280	COG0714	Associated with various cellular activities
D9623_28285	COG3256	nitric oxide reductase
D9623_28315	COG2223	nitrite transmembrane transporter activity
D9623_28365	COG0489	protein tyrosine kinase activity
D9623_28375	COG4964	Belongs to the GSP D family
D9623_28410	COG1278	Cold shock
D9623_28420	COG0513	Belongs to the DEAD box helicase family
D9623_28445	COG3842	ATPase activity
D9623_28475	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_28495	COG2610	gluconate transmembrane transporter activity
D9623_28525	COG3920	Histidine kinase
D9623_28555	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_28560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D9623_28575	COG0071	Belongs to the small heat shock protein (HSP20) family
D9623_28585	COG1802	Transcriptional regulator
D9623_28585	COG4626	Terminase
D9623_28595	COG3316	Transposase and inactivated derivatives
D9623_28685	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D9623_28705	COG0356	it plays a direct role in the translocation of protons across the membrane
D9623_28715	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9623_28720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D9623_28725	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D9623_28735	COG1566	PFAM secretion protein HlyD family protein
D9623_28750	COG2207	Transcriptional regulator
D9623_28765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9623_28775	COG0765	amino acid transport
D9623_28780	COG1126	abc transporter atp-binding protein
D9623_28785	COG1012	belongs to the aldehyde dehydrogenase family
D9623_28795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D9623_28805	COG2721	sulfolactate sulfo-lyase activity
D9623_28830	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D9623_28850	COG1414	Transcriptional regulator
D9623_28860	COG0601	transmembrane transport
D9623_28865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9623_28870	COG0444	Belongs to the ABC transporter superfamily
D9623_28875	COG4608	Belongs to the ABC transporter superfamily
D9623_28890	COG4302	ethanolamine ammonia-lyase activity
D9623_28895	COG4303	Ethanolamine ammonia lyase large subunit
D9623_28900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_28925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9623_28935	COG0457	Tetratricopeptide repeat
D9623_28935	COG0859	PFAM glycosyl transferase family 9
D9623_28965	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_28985	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_29000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9623_29005	COG0747	negative chemotaxis
D9623_29015	COG2201	protein-glutamate methylesterase activity
D9623_29035	COG4771	TonB-dependent receptor
D9623_29060	COG1169	isochorismate synthase
D9623_29065	COG1021	2,3-dihydroxybenzoate-AMP ligase
D9623_29070	COG3433	isochorismatase activity
D9623_29070	COG1535	isochorismatase
D9623_29075	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_29085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9623_29090	COG2382	esterase
D9623_29100	COG1960	acyl-CoA dehydrogenase activity
D9623_29105	COG2186	Transcriptional regulator
D9623_29110	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_29115	COG1309	transcriptional regulator
D9623_29125	COG1846	Transcriptional regulator
D9623_29130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D9623_29140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_29160	COG2226	methyltransferase
D9623_29185	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_29195	COG0411	ABC transporter
D9623_29250	COG0277	FAD linked oxidase domain protein
D9623_29265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9623_29280	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D9623_29285	COG0567	Dehydrogenase, E1 component
D9623_29310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9623_29315	COG1845	cytochrome c oxidase, subunit III
D9623_29325	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D9623_29345	COG1120	ATPase activity
D9623_29350	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D9623_29355	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D9623_29370	COG1802	Transcriptional regulator
D9623_29375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9623_29400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D9623_29410	COG5443	negative regulation of bacterial-type flagellum assembly
D9623_29430	COG2814	Major facilitator Superfamily
D9623_29445	COG1157	protein secretion by the type III secretion system
D9623_29450	COG1815	bacterial-type flagellum-dependent cell motility
D9623_29455	COG1558	bacterial-type flagellum-dependent cell motility
D9623_29460	COG1677	Flagellar hook-basal body complex protein FliE
D9623_29470	COG4794	Type iii secretion
D9623_29480	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9623_29485	COG1684	flagellar biosynthetic protein fliR
D9623_29490	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9623_29500	COG1522	sequence-specific DNA binding
D9623_29510	COG0028	Belongs to the TPP enzyme family
D9623_29520	COG4191	Histidine kinase
D9623_29530	COG5487	UPF0391 membrane protein
D9623_29535	COG0793	Belongs to the peptidase S41A family
D9623_29540	COG0583	DNA-binding transcription factor activity
D9623_29545	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_29570	COG3300	MHYT domain
D9623_29570	COG5001	Diguanylate cyclase
D9623_29595	COG1706	bacterial-type flagellum-dependent cell motility
D9623_29605	COG1256	bacterial-type flagellum assembly
D9623_29610	COG1749	Flagellar hook protein flgE
D9623_29635	COG0840	transmembrane signaling receptor activity
D9623_29640	COG0861	Integral membrane protein TerC family
D9623_29645	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_29655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_29660	COG1802	Transcriptional regulator
D9623_29665	COG0697	spore germination
D9623_29670	COG2116	formate transmembrane transporter activity
D9623_29675	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D9623_29680	COG0469	pyruvate kinase activity
D9623_29690	COG4251	negative regulation of phosphorylation
D9623_29695	COG5002	protein histidine kinase activity
D9623_29700	COG1309	transcriptional regulator
D9623_29705	COG1309	transcriptional regulator
D9623_29710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_29715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_29720	COG1737	Transcriptional regulator
D9623_29720	COG0837	glucose binding
D9623_29725	COG1882	Formate acetyltransferase
D9623_29755	COG0861	Integral membrane protein TerC family
D9623_29765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9623_29770	COG2353	YceI-like domain
D9623_29790	COG4566	intracellular signal transduction
D9623_29795	COG4566	intracellular signal transduction
D9623_29800	COG4191	Histidine kinase
D9623_29810	COG1538	Outer membrane efflux protein
D9623_29815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_29820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_29825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_29835	COG0427	acetyl-CoA hydrolase
D9623_29860	COG0243	molybdopterin cofactor binding
D9623_29950	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D9623_29960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_29965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_29975	COG0628	permease
D9623_29980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D9623_29990	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D9623_30020	COG1192	Involved in chromosome partitioning
D9623_30030	COG1653	transport
D9623_30045	COG3842	ATPase activity
D9623_30070	COG0840	transmembrane signaling receptor activity
D9623_30070	COG0840	transmembrane signaling receptor activity
D9623_30085	COG0411	ABC transporter
D9623_30095	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_30110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_30115	COG1473	amidohydrolase
D9623_30160	COG1971	Probably functions as a manganese efflux pump
D9623_30165	COG3290	protein histidine kinase activity
D9623_30165	COG0840	transmembrane signaling receptor activity
D9623_30190	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_30195	COG0366	Alpha amylase catalytic
D9623_30200	COG2388	GCN5-related N-acetyl-transferase
D9623_30215	COG4191	Histidine kinase
D9623_30215	COG0784	Response regulator, receiver
D9623_30220	COG0784	Response regulator, receiver
D9623_30220	COG5002	protein histidine kinase activity
D9623_30245	COG0840	transmembrane signaling receptor activity
D9623_30280	COG4615	Cyclic peptide transporter
D9623_30300	COG0586	Pfam SNARE associated Golgi protein
D9623_30315	COG3842	ATPase activity
D9623_30325	COG0395	ABC-type sugar transport system, permease component
D9623_30340	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D9623_30345	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_30370	COG2095	MarC family integral membrane protein
D9623_30385	COG0840	transmembrane signaling receptor activity
D9623_30390	COG0835	chemotaxis
D9623_30395	COG2201	protein-glutamate methylesterase activity
D9623_30405	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9623_30410	COG0745	RESPONSE REGULATOR receiver
D9623_30410	COG3706	GGDEF domain
D9623_30415	COG0643	Histidine kinase
D9623_30415	COG2198	Histidine kinase
D9623_30425	COG2197	response regulator
D9623_30440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_30450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9623_30480	COG2204	response regulator
D9623_30490	COG2985	domain, Protein
D9623_30505	COG3842	ATPase activity
D9623_30520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_30530	COG0251	oxidation-reduction process
D9623_30550	COG0747	negative chemotaxis
D9623_30560	COG0583	DNA-binding transcription factor activity
D9623_30570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9623_30575	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9623_30575	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9623_30580	COG1660	Displays ATPase and GTPase activities
D9623_30595	COG0642	Histidine kinase
D9623_30600	COG0745	RESPONSE REGULATOR receiver
D9623_30615	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D9623_30630	COG0739	heme binding
D9623_30680	COG2226	methyltransferase
D9623_30680	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D9623_30680	COG0596	Alpha beta hydrolase
D9623_30685	COG0183	Belongs to the thiolase family
D9623_30690	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_30700	COG2814	Major facilitator Superfamily
D9623_30705	COG0583	DNA-binding transcription factor activity
D9623_30715	COG3300	MHYT domain
D9623_30715	COG5001	Diguanylate cyclase
D9623_30720	COG0012	GTP binding
D9623_30740	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9623_30740	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9623_30765	COG1131	(ABC) transporter
D9623_30810	COG1254	Belongs to the acylphosphatase family
D9623_30815	COG2233	PERMEase
D9623_30820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9623_30825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9623_30835	COG1178	ABC-type Fe3 transport system permease component
D9623_30840	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_30845	COG3842	ATPase activity
D9623_30870	COG1045	serine acetyltransferase
D9623_30885	COG4191	Histidine kinase
D9623_30910	COG0784	Response regulator, receiver
D9623_30915	COG4251	negative regulation of phosphorylation
D9623_30940	COG0191	fructose-bisphosphate aldolase activity
D9623_30950	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D9623_30955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9623_31010	COG2022	thiamine diphosphate biosynthetic process
D9623_31020	COG2022	thiamine diphosphate biosynthetic process
D9623_31020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_31025	COG2239	Acts as a magnesium transporter
D9623_31055	COG0747	negative chemotaxis
D9623_31060	COG0601	transmembrane transport
D9623_31070	COG0444	Belongs to the ABC transporter superfamily
D9623_31075	COG4608	Belongs to the ABC transporter superfamily
D9623_31080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9623_31090	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_31135	COG0484	heat shock protein binding
D9623_31145	COG0564	pseudouridine synthase activity
D9623_31160	COG0156	8-amino-7-oxononanoate synthase activity
D9623_31170	COG4106	trans-aconitate 2-methyltransferase activity
D9623_31170	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D9623_31180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D9623_31190	COG0574	Belongs to the PEP-utilizing enzyme family
D9623_31190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D9623_31200	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D9623_31205	COG1278	Cold shock
D9623_31210	COG0318	PFAM AMP-dependent synthetase and ligase
D9623_31240	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D9623_31245	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D9623_31255	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9623_31260	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9623_31265	COG1129	ABC transporter
D9623_31270	COG1879	ABC-type sugar transport system periplasmic component
D9623_31310	COG4214	carbohydrate transport
D9623_31320	COG0129	dihydroxy-acid dehydratase activity
D9623_31335	COG0246	Mannitol dehydrogenase
D9623_31340	COG0725	ABC transporter, periplasmic molybdate-binding protein
D9623_31355	COG5039	Polysaccharide pyruvyl transferase
D9623_31360	COG2132	Multicopper oxidase
D9623_31370	COG1309	transcriptional regulator
D9623_31375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_31380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_31385	COG0702	epimerase
D9623_31390	COG1733	regulation of RNA biosynthetic process
D9623_31400	COG0583	DNA-binding transcription factor activity
D9623_31415	COG2133	pyrroloquinoline quinone binding
D9623_31450	COG1312	Catalyzes the dehydration of D-mannonate
D9623_31455	COG0246	Mannitol dehydrogenase
D9623_31470	COG1802	Transcriptional regulator
D9623_31475	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_31480	COG1917	Cupin 2, conserved barrel domain protein
D9623_31485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_31495	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D9623_31515	COG4774	siderophore transport
D9623_31520	COG0667	Aldo Keto reductase
D9623_31525	COG1802	Transcriptional regulator
D9623_31530	COG1803	Methylglyoxal synthase
D9623_31535	COG1904	glucuronate isomerase
D9623_31540	COG2721	sulfolactate sulfo-lyase activity
D9623_31575	COG0861	Integral membrane protein TerC family
D9623_31630	COG2188	Transcriptional regulator
D9623_31645	COG0154	amidase activity
D9623_31660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9623_31665	COG1960	acyl-CoA dehydrogenase activity
D9623_31670	COG2079	MmgE PrpD family protein
D9623_31690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9623_31695	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_31710	COG1595	DNA-templated transcription, initiation
D9623_31780	COG1132	(ABC) transporter
D9623_31795	COG2199	diguanylate cyclase activity
D9623_31795	COG2203	Gaf domain
D9623_31815	COG0405	Gamma-glutamyltransferase
D9623_31845	COG1858	cytochrome C peroxidase
D9623_31865	COG4964	Belongs to the GSP D family
D9623_31965	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D9623_31990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D9623_32005	COG4603	Belongs to the binding-protein-dependent transport system permease family
D9623_32015	COG0402	S-adenosylhomocysteine deaminase activity
D9623_32020	COG0840	transmembrane signaling receptor activity
D9623_32025	COG4191	Histidine kinase
D9623_32055	COG1414	Transcriptional regulator
D9623_32060	COG3383	formate dehydrogenase (NAD+) activity
D9623_32070	COG0028	Belongs to the TPP enzyme family
D9623_32085	COG1597	lipid kinase activity
D9623_32095	COG0628	permease
D9623_32100	COG3416	Protein conserved in bacteria
D9623_32145	COG1802	Transcriptional regulator
D9623_32150	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D9623_32155	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_32165	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D9623_32185	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9623_32195	COG1338	Plays a role in the flagellum-specific transport system
D9623_32200	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9623_32210	COG1766	The M ring may be actively involved in energy transduction
D9623_32250	COG3005	denitrification pathway
D9623_32260	COG0243	molybdopterin cofactor binding
D9623_32280	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D9623_32285	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
D9623_32290	COG4786	Flagellar basal body rod
D9623_32295	COG4786	Flagellar basal body rod
D9623_32305	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9623_32310	COG1360	Flagellar Motor Protein
D9623_32385	COG1012	belongs to the aldehyde dehydrogenase family
D9623_32385	COG1454	alcohol dehydrogenase
D9623_32440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9623_32470	COG4221	oxidoreductase activity
D9623_32485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9623_32490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9623_32495	COG0583	DNA-binding transcription factor activity
D9623_32500	COG0028	Belongs to the TPP enzyme family
D9623_32505	COG1012	belongs to the aldehyde dehydrogenase family
D9623_32530	COG4191	Histidine kinase
D9623_32530	COG0784	Response regulator, receiver
D9623_32535	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D9623_32575	COG2855	membrane
D9623_32600	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9623_32620	COG0683	leucine binding
D9623_32625	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_32650	COG3473	Maleate cis-trans isomerase
D9623_32655	COG0596	Alpha beta hydrolase
D9623_32660	COG2309	aminopeptidase activity
D9623_32665	COG1335	isochorismatase
D9623_32675	COG1609	Transcriptional regulator
D9623_32680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D9623_32680	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9623_32685	COG1105	Belongs to the carbohydrate kinase PfkB family
D9623_32690	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9623_32690	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9623_32700	COG3920	Histidine kinase
D9623_32705	COG2197	response regulator
D9623_32735	COG0583	DNA-binding transcription factor activity
D9623_32750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_32770	COG0411	ABC transporter
D9623_32780	COG0559	Belongs to the binding-protein-dependent transport system permease family
D9623_32795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D9623_32800	COG0251	oxidation-reduction process
D9623_32805	COG1522	sequence-specific DNA binding
D9623_32815	COG1414	Transcriptional regulator
D9623_32820	COG0280	phosphate acetyltransferase
D9623_32840	COG1012	belongs to the aldehyde dehydrogenase family
D9623_32845	COG0045	succinate-CoA ligase (ADP-forming) activity
D9623_32850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D9623_32855	COG0243	molybdopterin cofactor binding
D9623_32860	COG0437	4 iron, 4 sulfur cluster binding
D9623_32875	COG0028	Belongs to the TPP enzyme family
D9623_32880	COG1475	DNA binding
D9623_32885	COG1192	Involved in chromosome partitioning
D9623_32905	COG0546	phosphoglycolate phosphatase activity
D9623_32920	COG0438	transferase activity, transferring glycosyl groups
D9623_32925	COG0500	methyltransferase
D9623_32930	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D9623_32935	COG0579	oxidoreductase
D9623_32940	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D9623_32945	COG0297	glycogen (starch) synthase activity
D9623_32950	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D9623_32955	COG1088	dTDP-glucose 4,6-dehydratase activity
D9623_32975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9623_32990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9623_33010	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D9623_33015	COG3754	Rhamnan synthesis protein F
D9623_33075	COG0297	glycogen (starch) synthase activity
D9623_33085	COG1215	transferase activity, transferring glycosyl groups
D9623_33125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9623_33135	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D9623_33165	COG1192	Involved in chromosome partitioning
D9623_33170	COG1475	DNA binding
D9623_33180	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D9623_33195	COG1086	Polysaccharide biosynthesis protein
D9623_33205	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9623_33220	COG1051	belongs to the nudix hydrolase family
D9623_33240	COG0528	UMP kinase activity
D9623_33260	COG0861	Integral membrane protein TerC family
D9623_33265	COG0251	oxidation-reduction process
D9623_33275	COG0251	oxidation-reduction process
D9623_33280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9623_33300	COG1177	transmembrane transport
D9623_33305	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9623_33310	COG3842	ATPase activity
D9623_33325	COG1304	FMN binding
D9623_33330	COG1396	sequence-specific DNA binding
D9623_33340	COG1028	Short-chain dehydrogenase reductase Sdr
D9623_33345	COG3246	L-lysine catabolic process to acetate
D9623_33350	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9623_33355	COG2204	response regulator
D9623_33370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D9623_33375	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D9623_33380	COG1278	Cold shock
D9623_33390	COG0745	RESPONSE REGULATOR receiver
D9623_33390	COG4566	intracellular signal transduction
D9623_33405	COG0411	ABC transporter
D9623_33420	COG0683	leucine binding
D9623_33425	COG2814	Major facilitator Superfamily
D9623_33535	COG3772	lysozyme
D9623_33950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D9623_33955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9623_33985	COG0633	Ferredoxin
D9623_33990	COG2124	cytochrome p450
D9623_34005	COG0583	DNA-binding transcription factor activity
D9623_34035	COG2271	Major facilitator Superfamily
D9623_34065	COG1088	dTDP-glucose 4,6-dehydratase activity
D9623_34085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9623_34095	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9623_34115	COG0438	transferase activity, transferring glycosyl groups
D9623_34125	COG1216	Glycosyl transferase, family 2
D9623_34125	COG0438	transferase activity, transferring glycosyl groups
D9623_34135	COG0438	transferase activity, transferring glycosyl groups
D9623_34175	COG0463	Glycosyl transferase, family 2
D9623_34185	COG1215	transferase activity, transferring glycosyl groups
D9623_34190	COG0438	transferase activity, transferring glycosyl groups