locus-tag class description D3868_00055 ENOG4105NXH GreA GreB family elongation factor D3868_00060 ENOG4105C2J ABC transporter D3868_00065 ENOG4105UIB (ABC) transporter D3868_00100 ENOG4105BZU Histidine kinase D3868_00105 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) D3868_00110 ENOG4105CY0 Metallo-Beta-Lactamase D3868_00120 ENOG4105BZU Histidine kinase D3868_00125 ENOG4107JEE Short-chain dehydrogenase reductase Sdr D3868_00135 ENOG41067HS methyltransferase D3868_00145 ENOG4105EEI dihydropteroate synthase D3868_00150 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) D3868_00155 ENOG4105DWF phosphomethylpyrimidine kinase D3868_00160 ENOG4107SQD Transcriptional regulator, GntR family D3868_00175 ENOG4105HFZ Membrane D3868_00180 ENOG4105EXU Membrane D3868_00195 ENOG4105JAB phenazine biosynthesis protein, phzf family D3868_00200 ENOG4105DXM phenylacetic acid degradation protein D3868_00205 ENOG4105R8A Heat shock protein D3868_00210 ENOG4105C5F glutamine synthetase D3868_00215 ENOG4108YZA Nitrogen regulatory protein pii D3868_00230 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) D3868_00245 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation D3868_00250 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) D3868_00255 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) D3868_00260 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) D3868_00280 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain D3868_00285 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3868_00290 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain D3868_00295 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3868_00305 ENOG4107QIZ NADH dehydrogenase D3868_00315 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) D3868_00320 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3868_00325 ENOG4105DF2 NADH dehydrogenase subunit j D3868_00330 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3868_00335 ENOG4105D65 subunit l D3868_00340 ENOG4105C8S subunit m D3868_00345 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3868_00350 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase D3868_00355 ENOG4107QNB Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) D3868_00375 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D3868_00390 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) D3868_00400 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) D3868_00410 ENOG4108594 Permease of the drug metabolite transporter D3868_00420 ENOG4105C0B DNA polymerase III (alpha subunit) D3868_00425 ENOG4105CE9 30S ribosomal protein S2 D3868_00430 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) D3868_00435 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) D3868_00440 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) D3868_00445 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) D3868_00450 ENOG4105KNE Phosphatidate cytidylyltransferase D3868_00455 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) D3868_00460 ENOG4105DZP Membrane-associated zinc metalloprotease D3868_00465 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane D3868_00475 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) D3868_00480 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D3868_00485 ENOG4105GYT Protein of unknown function (DUF1009) D3868_00490 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D3868_00505 ENOG4105ETT transcriptional Regulator, LysR family D3868_00510 ENOG4108RXX maleylacetoacetate isomerase D3868_00520 ENOG4105BZN citrate synthase D3868_00525 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) D3868_00530 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 D3868_00535 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) D3868_00540 ENOG4105CVM Molybdenum cofactor synthesis domain protein D3868_00545 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D3868_00555 ENOG4105DK0 Indole-3-glycerol phosphate synthase D3868_00560 ENOG4107QYG anthranilate phosphoribosyltransferase D3868_00565 ENOG4105DDQ anthranilate synthase D3868_00590 ENOG4105CRQ synthase (Component I) D3868_00600 ENOG4105CP7 Triose-phosphate isomerase D3868_00605 ENOG4107EJC Preprotein translocase subunit SecG D3868_00610 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) D3868_00630 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E D3868_00640 ENOG41086XE Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity) D3868_00645 ENOG4105JIE May be involved in the transport of PQQ or its precursor to the periplasm (By similarity) D3868_00655 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) D3868_00665 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) D3868_00705 ENOG4107ZHV Transcriptional regulator D3868_00720 ENOG4105EV9 Alpha Beta Hydrolase D3868_00725 ENOG4105CJR Integral membrane protein (MviN D3868_00735 ENOG4105DD5 Flagellar motor switch protein D3868_00745 ENOG4107RCH Diaminopropionate ammonia-lyase D3868_00750 ENOG4105CHM Aminotransferase D3868_00770 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D3868_00775 ENOG4105D2X ABC transporter substrate-binding protein D3868_00780 ENOG4105ND9 Nitrogenase-associated protein D3868_00805 ENOG41080BE Methyl-accepting chemotaxis sensory transducer D3868_00835 ENOG4105BZU Histidine kinase D3868_00840 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) D3868_00850 ENOG4105VF7 tolerance protein D3868_00870 ENOG4105E39 Enoyl-CoA hydratase D3868_00880 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) D3868_00885 ENOG4108UJD 30S ribosomal protein S9 D3868_00890 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase D3868_00895 ENOG4108Z0R Transferase D3868_00905 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class D3868_00930 ENOG4105CHM Aminotransferase D3868_00935 ENOG4105D6E homoserine dehydrogenase D3868_00940 ENOG4105CBT Fructose-1,6-bisphosphatase D3868_00945 ENOG4105DCT glycerol dehydrogenase D3868_00950 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) D3868_00960 ENOG4108F3G Type I restriction-modification system, R subunit D3868_01015 ENOG4105CV8 reductase D3868_01025 ENOG4105FCD Major Facilitator D3868_01030 ENOG4105DGU Histone deacetylase D3868_01040 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) D3868_01045 ENOG41080XP Cbs domain D3868_01050 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D3868_01055 ENOG4105W8H transhydrogenase (subunit alpha D3868_01060 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D3868_01075 ENOG4105CFN oxalyl-CoA decarboxylase D3868_01080 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D3868_01085 ENOG4105CMV Succinyl-CoA synthetase subunit beta D3868_01095 ENOG4105DXI Major Facilitator superfamily D3868_01100 ENOG4105FCD Major Facilitator D3868_01110 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) D3868_01115 ENOG4105FCD Major Facilitator D3868_01125 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D3868_01130 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) D3868_01135 ENOG41060W2 glyoxylate carboligase D3868_01140 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase D3868_01145 ENOG4105DRR Transcriptional regulator, GntR family D3868_01150 ENOG4105CA9 Pyruvate kinase D3868_01160 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) D3868_01175 ENOG4108Z0R Transferase D3868_01185 ENOG4108JU8 Transcriptional regulator D3868_01190 ENOG4105MWK D-amino acid dehydrogenase, small subunit D3868_01200 ENOG4107R7Y intracellular protease Pfpi family D3868_01205 ENOG4105WH1 Two component transcriptional regulator luxr family D3868_01210 ENOG4108VB1 regulatoR D3868_01225 ENOG4108M9X Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) D3868_01230 ENOG4108YZ9 Urea amidohydrolase subunit gamma D3868_01235 ENOG4105KI2 Urea amidohydrolase subunit beta D3868_01240 ENOG4105CQM Urea amidohydrolase subunit alpha D3868_01245 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) D3868_01250 ENOG4105MMR Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) D3868_01255 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) D3868_01260 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) D3868_01265 ENOG4105T2N Domain of unknown function (DUF2382) D3868_01275 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH D3868_01320 ENOG4108WRK Transcriptional regulator D3868_01345 ENOG41067TZ transcriptional regulator, MarR family D3868_01355 ENOG4108UTW Plays a role in the regulation of phosphate uptake D3868_01375 ENOG4105CKK Glycosyl transferase, family 2 D3868_01395 ENOG4105DKQ ROK family D3868_01405 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_01410 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D3868_01415 ENOG4105C0Z ABC transporter D3868_01420 ENOG4108IV0 ABC, transporter D3868_01450 ENOG4105WH1 Two component transcriptional regulator luxr family D3868_01455 ENOG4105BZU Histidine kinase D3868_01475 ENOG4105H9W Short-chain dehydrogenase reductase Sdr D3868_01480 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase D3868_01495 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) D3868_01510 ENOG4105DHJ ABC, transporter D3868_01515 ENOG4105CY3 ABC transporter, permease D3868_01520 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D3868_01530 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase D3868_01535 ENOG4105K9Q Binds to the 23S rRNA (By similarity) D3868_01545 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) D3868_01550 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) D3868_01555 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D3868_01565 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D3868_01570 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D3868_01575 ENOG4105HHA aminodeoxychorismate lyase D3868_01585 ENOG4105E4C Lytic transglycosylase catalytic D3868_01590 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D3868_01595 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) D3868_01600 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) D3868_01610 ENOG4108V1U phospholipid-binding protein D3868_01615 ENOG4105D52 delta-aminolevulinic acid dehydratase D3868_01625 ENOG4105CBD Diacylglycerol kinase D3868_01630 ENOG4105E39 Enoyl-CoA hydratase D3868_01640 ENOG4105C0Z ABC transporter D3868_01645 ENOG4108IV0 ABC, transporter D3868_01655 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_01670 ENOG4105DCF alanine dehydrogenase D3868_01680 ENOG4105CGH 5'-nucleotidase D3868_01685 ENOG4105DDQ anthranilate synthase D3868_01690 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) D3868_01695 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family D3868_01760 ENOG4105DGU Histone deacetylase D3868_01805 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase D3868_01810 ENOG4105C28 cystathionine D3868_01815 ENOG4107QXX ABC transporter D3868_01820 ENOG4105EZ7 amino acid ABC transporter D3868_01825 ENOG4105DRP amino acid AbC transporter D3868_01830 ENOG4105CDA abc transporter atp-binding protein D3868_01835 ENOG4105CIH Imidazole acetol-phosphate transaminase D3868_01855 ENOG4105KHC sulfurtransferase D3868_01870 ENOG41087AY ADP-Ribose pyrophosphatase D3868_01875 ENOG4105C0H protease D3868_01900 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) D3868_01910 ENOG4105DFG type I secretion outer membrane protein D3868_01920 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) D3868_01940 ENOG4105DZ1 carboxypeptidase D3868_01945 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) D3868_01950 ENOG4107QRG dna polymerase iii D3868_01955 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) D3868_01960 ENOG4105F8V Hydrolase, tatD family D3868_01965 ENOG4108H5C Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) D3868_01980 ENOG4108ZF3 Phosphatase D3868_01990 ENOG4105DWY Agmatine deiminase D3868_01995 ENOG4105D38 putrescine abc transporter D3868_02000 ENOG4105F38 ABC transporter, permease D3868_02005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_02010 ENOG4108HM4 ABC transporter D3868_02015 ENOG4105CFQ glutamine synthetase D3868_02020 ENOG4105CJP fad dependent oxidoreductase D3868_02050 ENOG4105DU1 integral membrane protein, terc D3868_02070 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3868_02105 ENOG4108ZAF Molybdopterin D3868_02110 ENOG4105M00 molybdopterin converting factor, subunit 1 D3868_02115 ENOG4105CVM Molybdenum cofactor synthesis domain protein D3868_02120 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b D3868_02130 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) D3868_02180 ENOG4107GFK fumarate D3868_02185 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) D3868_02215 ENOG4105WH1 Two component transcriptional regulator luxr family D3868_02230 ENOG4105DFH Transport of potassium into the cell (By similarity) D3868_02240 ENOG4105BZU Histidine kinase D3868_02255 ENOG4105BZU Histidine kinase D3868_02285 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) D3868_02290 ENOG4105D94 Major Facilitator Superfamily D3868_02305 ENOG4108Z6Z Transcriptional regulator D3868_02310 ENOG4105CEY Amp-dependent synthetase and ligase D3868_02350 ENOG4105C11 sulfate adenylyltransferase), subunit 2 D3868_02355 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) D3868_02360 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D3868_02375 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) D3868_02390 ENOG4105CKD glutathione-regulated potassium-efflux system protein D3868_02405 ENOG4105WJX transcriptional regulator MERR family D3868_02410 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) D3868_02415 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D3868_02420 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) D3868_02425 ENOG41082R8 50S ribosomal protein l32 D3868_02445 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for D3868_02455 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) D3868_02460 ENOG4107XZX Involved in the transcription termination process (By similarity) D3868_02465 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) D3868_02470 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) D3868_02480 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) D3868_02485 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) D3868_02490 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) D3868_02495 ENOG4108YZG isomerase D3868_02515 ENOG4108Z9Z response to DNA damage stimulus D3868_02545 ENOG4107T0X DNA ligase D3868_02555 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) D3868_02565 ENOG4107RHB Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) D3868_02615 ENOG4105DS0 Transcriptional regulator, Crp Fnr family D3868_02640 ENOG41065KQ synthase D3868_02660 ENOG4105D5G Transposase D3868_02665 ENOG4105CB5 ATP-dependent DNA helicase recG D3868_02670 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) D3868_02675 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase D3868_02710 ENOG4108YZN class I peptide chain release factor D3868_02740 ENOG41060WC Enoyl-CoA hydratase D3868_02750 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process D3868_02755 ENOG4105NZG Ferredoxin D3868_02770 ENOG4105DC8 reductase D3868_02775 ENOG4105WEF catalase D3868_02785 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase D3868_02795 ENOG4105C26 Dehydrogenase D3868_02800 ENOG4107R03 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) D3868_02830 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D3868_02835 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) D3868_02845 ENOG4105EAQ (twin-arginine translocation) pathway signal D3868_02855 ENOG41082X2 rubredoxin D3868_02870 ENOG4105D78 K07001 NTE family protein D3868_02875 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) D3868_02900 ENOG4108ZXC Two component transcriptional regulator, luxr family D3868_02905 ENOG4105BZU Histidine kinase D3868_02910 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D3868_02915 ENOG4108RA0 tripartite ATP-independent periplasmic transporter, DctQ component D3868_02920 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_02925 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA D3868_02930 ENOG4105C8Q Methyl-accepting chemotaxis D3868_02940 ENOG4105C3J Cysteine desulfurase D3868_02945 ENOG4105EA8 2-Nitropropane dioxygenase D3868_02950 ENOG4106TD9 Diguanylate cyclase D3868_02965 ENOG4105C3R Methionine synthase D3868_02975 ENOG4105SYT Methylenetetrahydrofolate reductase D3868_03000 ENOG4105C5H ABC transporter D3868_03005 ENOG4108UPT UPF0178 protein D3868_03010 ENOG4108IRC dna polymerase iii D3868_03035 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) D3868_03040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D3868_03050 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) D3868_03055 ENOG4105CG3 alpha amylase, catalytic region D3868_03070 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase D3868_03075 ENOG4105ED9 Protein of unknown function (DUF455) D3868_03090 ENOG4105C1G acyl-Coa dehydrogenase D3868_03095 ENOG4105CHR reductase D3868_03100 ENOG4105CEY Amp-dependent synthetase and ligase D3868_03105 ENOG4107V6Q Cyclic nucleotide-binding domain D3868_03110 ENOG4105E6M Sulphatase-modifying factor protein D3868_03115 ENOG4105F8J Adenylate Guanylate cyclase D3868_03150 ENOG4105IJJ transcriptional regulator, crp fnr family D3868_03165 ENOG4106HB6 Alpha beta hydrolase D3868_03180 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D3868_03200 ENOG4107QRT dEAD DEAH box helicase D3868_03215 ENOG4105CVP deoxyribo-dipyrimidine photolyase D3868_03225 ENOG4105MYN Zinc uptake regulation protein D3868_03230 ENOG4105CKI cobalamin synthesis protein D3868_03240 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) D3868_03245 ENOG4107R3E Citrate transporter D3868_03250 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) D3868_03265 ENOG4107U4H Methyl-accepting chemotaxis D3868_03270 ENOG41076HS cation diffusion facilitator family transporter D3868_03275 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) D3868_03280 ENOG4105MQ2 17 kDa surface antigen D3868_03285 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) D3868_03305 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D3868_03310 ENOG4105BZU Histidine kinase D3868_03325 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D3868_03350 ENOG4105KPY Small multidrug resistance protein D3868_03355 ENOG4108W6C Dehydrogenase D3868_03360 ENOG4108UKZ OsmC family D3868_03370 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) D3868_03380 ENOG4108UZ3 Transporter D3868_03385 ENOG4105CAQ asparagine synthetase D3868_03400 ENOG4105CGN Glycosyl transferase (Group 1 D3868_03405 ENOG4105ESV Glycosyl transferase, family 4 D3868_03425 ENOG4105KCK Peptidoglycan-associated lipoprotein D3868_03430 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) D3868_03440 ENOG4108ZZF transport protein (ExbD) D3868_03445 ENOG4105E02 MotA TolQ exbB proton channel D3868_03450 ENOG4107YD3 Thioesterase D3868_03455 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) D3868_03460 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) D3868_03470 ENOG4105CDY transcriptional regulatory protein D3868_03475 ENOG4105D48 metallophosphoesterase D3868_03480 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase D3868_03525 ENOG4105EIE fructose-bisphosphate aldolase D3868_03530 ENOG4106HMZ Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) D3868_03535 ENOG4105EJ9 Membrane D3868_03540 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation D3868_03545 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family D3868_03550 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) D3868_03555 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) D3868_03560 ENOG4105ECY inositol monophosphatase D3868_03575 ENOG4106VK6 Flagellar motor protein D3868_03580 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor D3868_03590 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) D3868_03595 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) D3868_03610 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) D3868_03615 ENOG4105CUV Homoserine Kinase D3868_03620 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D3868_03625 ENOG4105CEY Amp-dependent synthetase and ligase D3868_03635 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) D3868_03640 ENOG4108UJU UPF0301 protein D3868_03650 ENOG4105D9U N-acetyltransferase D3868_03655 ENOG4105C1V Peptidase, M16 D3868_03660 ENOG4105D98 threonine synthase D3868_03670 ENOG4105CTD carboxy-peptidase D3868_03685 ENOG4107QS1 Cytochrome C Oxidase, Subunit III D3868_03695 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) D3868_03705 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) D3868_03715 ENOG4105D1U peptidase U62 modulator of DNA gyrase D3868_03720 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) D3868_03725 ENOG4105E3R (LipO)protein D3868_03745 ENOG4105E4C Lytic transglycosylase catalytic D3868_03765 ENOG4105C5W Aldolase D3868_03780 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3868_03790 ENOG4107WDG serine threonine protein kinase D3868_03795 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis D3868_03800 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) D3868_03810 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) D3868_03825 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) D3868_03830 ENOG4107S2Z UPF0761 membrane protein D3868_03835 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH D3868_03845 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase D3868_03855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D3868_03865 ENOG4105D07 Signal peptide peptidase, SppA D3868_03875 ENOG4105BZU Histidine kinase D3868_03880 ENOG4105BZU Histidine kinase D3868_03895 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3868_03905 ENOG4105C02 permease D3868_03910 ENOG41062D9 Histidine kinase D3868_03920 ENOG4105C0H protease D3868_03930 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D3868_03935 ENOG4105M4H endoribonuclease L-psp D3868_03945 ENOG4105C9U ATP-dependent DNA helicase RecQ D3868_03975 ENOG4105CSM endonuclease III D3868_04000 ENOG4108EKC n-acetylglutamate synthase D3868_04010 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3868_04015 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) D3868_04025 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D3868_04045 ENOG4108JQ1 Dehydrogenase D3868_04050 ENOG4105K89 arsenate reductase D3868_04055 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) D3868_04110 ENOG4108TPP exopolysaccharide synthesis D3868_04160 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D3868_04180 ENOG4105C7B Threonine dehydratase D3868_04195 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) D3868_04200 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) D3868_04215 ENOG4105D00 flagellar biosynthetic protein flhB D3868_04220 ENOG4105D19 Role in flagellar biosynthesis (By similarity) D3868_04225 ENOG4105VS8 Flagellar biosynthetic protein fliq D3868_04230 ENOG4105UVF flagellar hook-basal body complex protein fliE D3868_04235 ENOG4108ZC9 flagellar basal-body rod protein flgc D3868_04240 ENOG4105SFI flagellar basal-body rod protein D3868_04245 ENOG4105VM1 flagellar D3868_04260 ENOG4105CN7 Flagellar biosynthetic protein FliP D3868_04265 ENOG4105DFH Transport of potassium into the cell (By similarity) D3868_04275 ENOG4105ER2 Ompa motb domain protein D3868_04315 ENOG4105KTQ flagellar basal-body rod protein D3868_04320 ENOG4105CGA flagellar basal-body rod protein FlgG D3868_04330 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) D3868_04340 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters D3868_04345 ENOG4106909 Flagellar assembly regulator FliX D3868_04350 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) D3868_04355 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj D3868_04370 ENOG410822I Flagellar hook capping protein D3868_04405 ENOG4105BZ1 (ABC) transporter D3868_04410 ENOG41082FS 50S ribosomal protein L31 D3868_04420 ENOG4108ZNX Heat shock protein D3868_04430 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 D3868_04440 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) D3868_04455 ENOG4105EMF GntR family transcriptional regulator D3868_04460 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) D3868_04465 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) D3868_04470 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) D3868_04475 ENOG41084HQ 50S ribosomal protein L30 D3868_04480 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) D3868_04485 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) D3868_04490 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) D3868_04495 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) D3868_04500 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) D3868_04505 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits D3868_04510 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) D3868_04515 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) D3868_04520 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal D3868_04525 ENOG41083MP 50s ribosomal protein l29 D3868_04530 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) D3868_04535 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) D3868_04540 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) D3868_04545 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) D3868_04550 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity D3868_04555 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) D3868_04560 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) D3868_04565 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) D3868_04570 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) D3868_04575 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D3868_04580 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) D3868_04585 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) D3868_04590 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) D3868_04600 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D3868_04605 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D3868_04610 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) D3868_04615 ENOG4108VZM 50s ribosomal protein L10 D3868_04620 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) D3868_04625 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) D3868_04645 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) D3868_04660 ENOG4105C2N RNA methyltransferase TrmH family group 3 D3868_04705 ENOG4105C0Z ABC transporter D3868_04710 ENOG4108IV0 ABC, transporter D3868_04735 ENOG4105DKQ ROK family D3868_04750 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) D3868_04755 ENOG4108IV0 ABC, transporter D3868_04760 ENOG4105C0Z ABC transporter D3868_04770 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_04815 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D3868_04830 ENOG4105E6M Sulphatase-modifying factor protein D3868_04850 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D3868_04885 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein D3868_04900 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D3868_04905 ENOG4105C03 ribonuclease D3868_04910 ENOG4108RRZ Transcription elongation factor GreB D3868_04935 ENOG4105CHM Aminotransferase D3868_04945 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) D3868_04960 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D3868_04970 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) D3868_04985 ENOG4105CMS peptidase U62, modulator of DNA gyrase D3868_04995 ENOG4105CBD Diacylglycerol kinase D3868_05005 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) D3868_05015 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase D3868_05020 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) D3868_05030 ENOG4108NIW Leucine export protein LeuE D3868_05055 ENOG410846T CoA-transferase family III D3868_05065 ENOG4107Y2X deaminase D3868_05090 ENOG4105W3S hemerythrin-like, metal-binding protein D3868_05095 ENOG4107RTZ reductase D3868_05125 ENOG4105K6T rare lipoprotein A D3868_05135 ENOG4108Z7G MaoC domain protein dehydratase D3868_05140 ENOG4105DTN riboflavin biosynthesis protein ribF D3868_05145 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) D3868_05150 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) D3868_05155 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) D3868_05180 ENOG4107QP8 phosphohexose isomerase D3868_05220 ENOG4107QN1 sodium solute D3868_05235 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) D3868_05260 ENOG4107Z6I Thiamine biosynthesis protein D3868_05265 ENOG4105E6M Sulphatase-modifying factor protein D3868_05270 ENOG4107QRH Arylsulfatase (Ec 3.1.6.1) D3868_05275 ENOG4105CI0 Citrate lyase D3868_05290 ENOG4105ERH Fumarylacetoacetate hydrolase D3868_05295 ENOG4107414 GntR family transcriptional regulator D3868_05300 ENOG4105CPC Aldo Keto reductase D3868_05320 ENOG4105EWK phytoene D3868_05325 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D3868_05330 ENOG4105C2D reductase D3868_05360 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) D3868_05375 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D3868_05405 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) D3868_05415 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) D3868_05435 ENOG4105FB9 CRISPR-associated protein D3868_05445 ENOG4107S1E Beta-lactamase D3868_05450 ENOG4107RP9 extracellular solute-binding protein, family 3 D3868_05455 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) D3868_05460 ENOG4105CG3 alpha amylase, catalytic region D3868_05470 ENOG4106H78 methyltransferase D3868_05475 ENOG4105FE9 pseudouridine synthase D3868_05480 ENOG4105WKW Pfam:DUF1458 D3868_05485 ENOG4108Z6B deaminase D3868_05500 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D3868_05510 ENOG4105EKE dihydroorotase D3868_05515 ENOG4105CUT histidyl-tRNA synthetase D3868_05555 ENOG4108I62 cina-like protein D3868_05560 ENOG4105PW4 Sugar fermentation stimulation protein homolog D3868_05570 ENOG4105W5Q DNA repair protein (RadC D3868_05580 ENOG4105BZU Histidine kinase D3868_05585 ENOG4105C83 adenylosuccinate lyase D3868_05600 ENOG4107QPR SAICAR synthetase D3868_05605 ENOG4105VR9 phosphoribosylformylglycinamidine synthase D3868_05615 ENOG4108RPX mosc domain containing protein D3868_05625 ENOG4105ETT transcriptional Regulator, LysR family D3868_05630 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I D3868_05635 ENOG4107QIK phosphoribosylformylglycinamidine synthase D3868_05645 ENOG4105M2J Glutaredoxin D3868_05655 ENOG4105FR1 rard protein D3868_05665 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D3868_05675 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) D3868_05680 ENOG4105XEI Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO (By similarity) D3868_05690 ENOG4105DY0 carbon monoxide dehydrogenase operon C protein D3868_05700 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) D3868_05710 ENOG4105BZU Histidine kinase D3868_05720 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) D3868_05725 ENOG4105C8N cysteinyl-tRNA synthetase D3868_05735 ENOG4107RA9 decarboxylase D3868_05745 ENOG4105C4K Nad synthetase D3868_05750 ENOG4108UDB Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) D3868_05765 ENOG4107R6D beta-lactam binding protein AmpH D3868_05795 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_05800 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) D3868_05820 ENOG4105C0Z ABC transporter D3868_05825 ENOG4108IV0 ABC, transporter D3868_05840 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) D3868_05845 ENOG4105K46 50S ribosomal protein l27 D3868_05850 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control D3868_05855 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) D3868_05860 ENOG4107VXZ Hydrolase D3868_05880 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding D3868_05885 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) D3868_05900 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) D3868_05905 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) D3868_05915 ENOG4105CN1 protease D3868_05925 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) D3868_05935 ENOG4107ZDE Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) D3868_05940 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) D3868_05945 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) D3868_05950 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) D3868_05955 ENOG4105E3N F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D3868_05970 ENOG4105C25 Primosomal protein n' D3868_05975 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D3868_05985 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D3868_05990 ENOG4107QN2 dihydrolipoyl dehydrogenase D3868_06000 ENOG4105EBM Alpha Beta Hydrolase Fold protein D3868_06010 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) D3868_06030 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) D3868_06050 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) D3868_06055 ENOG4105BZA Phosphoglycerate kinase D3868_06060 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) D3868_06065 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) D3868_06070 ENOG4107QMP dna polymerase iii subunits gamma and tau D3868_06080 ENOG4105G9V cytochrome C D3868_06085 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) D3868_06110 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D3868_06130 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component D3868_06140 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component D3868_06145 ENOG4108JQ5 ABC transporter D3868_06155 ENOG4108R99 pseudouridine synthase D3868_06160 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase D3868_06180 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D3868_06185 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) D3868_06210 ENOG4107F83 nucleotidyltransferase DNA polymerase involved in DNA D3868_06230 ENOG4105E3E D3868_06250 ENOG4105D4P Coproporphyrinogen iii oxidase D3868_06255 ENOG4105CYM Glutathione S-transferase D3868_06265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D3868_06285 ENOG4105C0R drug resistance transporter emrb qaca subfamily D3868_06295 ENOG4105ETT transcriptional Regulator, LysR family D3868_06330 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D3868_06345 ENOG4106PGW Short-chain dehydrogenase reductase Sdr D3868_06375 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D3868_06380 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) D3868_06385 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) D3868_06390 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_06405 ENOG4105D29 Helix-turn-helix type 11 domain protein D3868_06410 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D3868_06425 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) D3868_06430 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) D3868_06435 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) D3868_06440 ENOG4105K5M 30s ribosomal protein S16 D3868_06445 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY D3868_06470 ENOG4105BZU Histidine kinase D3868_06480 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) D3868_06495 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) D3868_06500 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) D3868_06515 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D3868_06525 ENOG4105CJ1 ABC, transporter D3868_06530 ENOG4105TX3 Histidine kinase D3868_06560 ENOG4108IJ1 Dehydrogenase D3868_06570 ENOG4105C30 Nad-dependent epimerase dehydratase D3868_06585 ENOG4105CG5 Glycosyl transferase (Group 1 D3868_06615 ENOG4108NV9 Glycosyl Transferase D3868_06625 ENOG4105VG0 50S ribosomal protein l34 D3868_06630 ENOG41087PG RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) D3868_06635 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) D3868_06640 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins D3868_06645 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) D3868_06660 ENOG4105CAS nag kinase D3868_06670 ENOG4107QUT magnesium and cobalt transport protein CorA D3868_06685 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) D3868_06695 ENOG4107QP3 malate synthase g D3868_06700 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D3868_06715 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) D3868_06720 ENOG4105D49 3-dehydroquinate synthase D3868_06725 ENOG41080XP Cbs domain D3868_06740 ENOG4105M85 Bola protein D3868_06770 ENOG4107QKW extracellular solute-binding protein family 1 D3868_06775 ENOG4105EUB pirin domain protein D3868_06785 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) D3868_06790 ENOG4105BZU Histidine kinase D3868_06795 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase D3868_06800 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) D3868_06815 ENOG4105CIF Ornithine Cyclodeaminase D3868_06825 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) D3868_06835 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) D3868_06840 ENOG4105CAT Cytidine monophosphate kinase D3868_06845 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase D3868_06850 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D3868_06865 ENOG4105EUB pirin domain protein D3868_06880 ENOG4105BZU Histidine kinase D3868_06885 ENOG4105BZU Histidine kinase D3868_06890 ENOG4105BZU Histidine kinase D3868_06900 ENOG4105CKK Glycosyl transferase, family 2 D3868_06910 ENOG4108ZNX Heat shock protein D3868_06940 ENOG4105EXC Acyl-transferase D3868_06950 ENOG4108I0Z Aconitate hydratase D3868_06975 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) D3868_06995 ENOG4107QN1 sodium solute D3868_07000 ENOG41062QD Membrane D3868_07020 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) D3868_07030 ENOG4105VW4 glutaredoxin 3 D3868_07035 ENOG4105C5T Phosphoribosyl pyrophosphate synthase D3868_07040 ENOG4105VS8 Flagellar biosynthetic protein fliq D3868_07045 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) D3868_07065 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) D3868_07070 ENOG4105C1J atp-dependent rna helicase D3868_07075 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) D3868_07080 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving D3868_07085 ENOG4107TF3 peptidylprolyl cis-trans isomerase D3868_07090 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) D3868_07100 ENOG4105M6F mutator MutT protein D3868_07105 ENOG4105C9U ATP-dependent DNA helicase RecQ D3868_07130 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_07135 ENOG410835K Tripartite ATP-Independent Periplasmic transporter DctQ D3868_07140 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D3868_07170 ENOG4105DEN Luciferase family D3868_07175 ENOG4105E0X reductase D3868_07185 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 D3868_07190 ENOG4105VEQ Cold shock protein D3868_07225 ENOG4108JQ7 (ABC) transporter D3868_07235 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D3868_07240 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D3868_07250 ENOG4105DEF Extracellular solute-binding protein, family 5 D3868_07280 ENOG4105BZU Histidine kinase D3868_07310 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase D3868_07320 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D3868_07335 ENOG4105FM1 phage shock protein C D3868_07340 ENOG4105YYT phage shock protein B D3868_07345 ENOG41087YS Phage shock protein A D3868_07350 ENOG4105E51 psp operon transcriptional activator D3868_07360 ENOG4108JQC penicillin-binding protein 1A D3868_07375 ENOG4105CUW cytochrome C-TYPE protein D3868_07380 ENOG4105CA0 peroxidase D3868_07385 ENOG4105CH6 catalase D3868_07390 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) D3868_07395 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) D3868_07400 ENOG4105P0T Usg family D3868_07405 ENOG4105KUS lysozyme D3868_07415 ENOG4107TQK Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) D3868_07440 ENOG4108JQ7 (ABC) transporter D3868_07445 ENOG4105D8X mechanosensitive ion channel D3868_07450 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D3868_07455 ENOG4107SW0 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) D3868_07465 ENOG4105DP0 ferredoxin-NADP reductase D3868_07470 ENOG4105CFF transcriptional regulator D3868_07480 ENOG4108Z0Z intracellular protease Pfpi family D3868_07485 ENOG4105BZU Histidine kinase D3868_07495 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein D3868_07500 ENOG4105DQU oxidoreductase, subunit beta D3868_07520 ENOG4108N8X transition metal ion binding D3868_07535 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) D3868_07540 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D3868_07550 ENOG4105DEF Extracellular solute-binding protein, family 5 D3868_07625 ENOG4108YXQ IS66 Orf2 family protein D3868_07630 ENOG4105D5G Transposase D3868_07655 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) D3868_07680 ENOG4105VU5 Resolvase domain-containing protein D3868_07790 ENOG4105DDI hemolysin-type calcium-binding region D3868_07820 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta D3868_07855 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D3868_07925 ENOG4105CNU cell division protein FtsK D3868_07930 ENOG4105CIH Imidazole acetol-phosphate transaminase D3868_07935 ENOG4108YZA Nitrogen regulatory protein pii D3868_07945 ENOG4107XID 2'-5' rna ligase D3868_07960 ENOG4108UJV acyl-CoA thioesterase i D3868_07965 ENOG4108I0Y (ABC) transporter D3868_07975 ENOG4105BZU Histidine kinase D3868_07980 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) D3868_07985 ENOG4105CFG Acts as a chaperone (By similarity) D3868_08005 ENOG4107SDU Methyl-accepting chemotaxis D3868_08010 ENOG4108VYJ response regulator receiver protein D3868_08015 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ D3868_08020 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) D3868_08025 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) D3868_08030 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D3868_08035 ENOG4105CSA Coproporphyrinogen iii oxidase D3868_08045 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) D3868_08070 ENOG41063JG Transcriptional regulator D3868_08075 ENOG41082FP UPF0102 protein D3868_08080 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) D3868_08100 ENOG4105WN5 stage II sporulation protein D3868_08110 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D3868_08125 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) D3868_08150 ENOG4105BZU Histidine kinase D3868_08160 ENOG4105C31 Tryptophanyl-tRNA synthetase D3868_08165 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) D3868_08175 ENOG4105K5B UPF0225 protein D3868_08190 ENOG4105EQK -acetyltransferase D3868_08195 ENOG4108IND Tetr family transcriptional regulator D3868_08200 ENOG4105F6U Short-chain dehydrogenase reductase Sdr D3868_08215 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) D3868_08220 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) D3868_08225 ENOG4108Z86 Glutamine amidotransferase D3868_08250 ENOG4105CPK Glycosyl transferase (Group 1 D3868_08255 ENOG4105BZU Histidine kinase D3868_08260 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) D3868_08270 ENOG4105BZ1 (ABC) transporter D3868_08275 ENOG410870F Cyclic nucleotide-binding protein D3868_08305 ENOG4105DEF Extracellular solute-binding protein, family 5 D3868_08310 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D3868_08315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D3868_08325 ENOG4107YM4 Beta-lactamase domain-containing protein D3868_08345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D3868_08350 ENOG4107QJN gtp cyclohydrolase ii D3868_08365 ENOG4105DFA alanine racemase domain protein D3868_08390 ENOG4105C8T Leucyl-tRNA synthetase D3868_08410 ENOG4105FA0 parb-like partition protein D3868_08415 ENOG4107QJE Chromosome Partitioning Protein D3868_08420 ENOG4107YTN Specifically methylates the N7 position of guanine in position 527 of 16S rRNA (By similarity) D3868_08425 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) D3868_08430 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) D3868_08435 ENOG4105NZG Ferredoxin D3868_08450 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D3868_08455 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein D3868_08460 ENOG4107RZZ dna polymerase iii epsilon subunit D3868_08465 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) D3868_08470 ENOG4105E2X shikimate dehydrogenase D3868_08475 ENOG4108UHJ MAF-like protein D3868_08480 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) D3868_08485 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) D3868_08490 ENOG4108YXA Membrane D3868_08510 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) D3868_08515 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) D3868_08530 ENOG4105CA3 membrane-bound lytic murein transglycosylase D3868_08540 ENOG4105K59 histidine triad (HIT) protein D3868_08550 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) D3868_08560 ENOG4108154 Acetyltransferase (GNAT) family D3868_08570 ENOG4105ECC imidazole-glycerol-phosphate dehydratase D3868_08580 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) D3868_08585 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) D3868_08590 ENOG4105C5H ABC transporter D3868_08595 ENOG4105BZU Histidine kinase D3868_08610 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) D3868_08620 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D3868_08625 ENOG4105C8Q Methyl-accepting chemotaxis D3868_08640 ENOG4105FAV ABC, transporter D3868_08645 ENOG4105FDK ABC transporter D3868_08655 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) D3868_08660 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D3868_08670 ENOG4105CSM endonuclease III D3868_08690 ENOG4108VCT Sulfite exporter TauE/SafE D3868_08720 ENOG41083MR nifu domain-containing protein D3868_08735 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D3868_08765 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D3868_08770 ENOG4105C9A Phoh family D3868_08775 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) D3868_08780 ENOG4107RCQ (CBS) domain D3868_08785 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) D3868_08790 ENOG4108WRK Transcriptional regulator D3868_08795 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP D3868_08810 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) D3868_08825 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) D3868_08830 ENOG4107ZGG Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) D3868_08835 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) D3868_08840 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) D3868_08845 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) D3868_08855 ENOG4105CGZ zinc metallopeptidase D3868_08865 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein D3868_08870 ENOG4107VXM glycerophosphoryl diester phosphodiesterase D3868_08885 ENOG4108RAC Rubrerythrin D3868_08910 ENOG4105CD5 CoA-binding domain protein D3868_08915 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) D3868_08920 ENOG4105F0N pyrophosphate phospho-hydrolase D3868_08925 ENOG4105E43 Extracellular solute-binding protein, family 5 D3868_08935 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) D3868_08940 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D3868_08945 ENOG4105RQ9 TPR repeat-containing protein D3868_08955 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) D3868_08965 ENOG4105E39 Enoyl-CoA hydratase D3868_08970 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) D3868_08975 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) D3868_08980 ENOG4107RUE extracellular solute-binding protein family 1 D3868_08985 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_09005 ENOG4105F38 ABC transporter, permease D3868_09010 ENOG4105D38 putrescine abc transporter D3868_09025 ENOG4105E3B Multicopper oxidase D3868_09035 ENOG4105DR4 Methyltransferase D3868_09060 ENOG4105D6P C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) D3868_09075 ENOG4105C59 p-type ATPase D3868_09085 ENOG4105DS0 Transcriptional regulator, Crp Fnr family D3868_09090 ENOG4105C6K Malic enzyme D3868_09100 ENOG4105PWN phosphate abc transporter D3868_09105 ENOG4105C8U phosphate abc transporter D3868_09115 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) D3868_09120 ENOG4108UTW Plays a role in the regulation of phosphate uptake D3868_09125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D3868_09140 ENOG4105D06 uba thif-type nad fad binding protein D3868_09155 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family D3868_09160 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) D3868_09170 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D3868_09175 ENOG4105VEQ Cold shock protein D3868_09180 ENOG4105BZU Histidine kinase D3868_09185 ENOG4105CC5 ABC transporter D3868_09190 ENOG4105CC5 ABC transporter D3868_09195 ENOG4105DIK (ABC) transporter D3868_09200 ENOG4105DSE periplasmic solute binding protein D3868_09225 ENOG41090R7 Ferric uptake D3868_09235 ENOG4105BZU Histidine kinase D3868_09240 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) D3868_09255 ENOG4105VEJ Heat shock protein D3868_09260 ENOG4105EE5 Membrane protein terC D3868_09275 ENOG4105CBP Major Facilitator D3868_09285 ENOG4108Z4U Ferredoxin D3868_09310 ENOG4108T5G Adenylate D3868_09315 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3868_09325 ENOG41082BR 50S ribosomal protein L35 D3868_09330 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) D3868_09335 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) D3868_09340 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) D3868_09350 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D3868_09370 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) D3868_09380 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) D3868_09385 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) D3868_09390 ENOG4105BZU Histidine kinase D3868_09400 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) D3868_09420 ENOG4105K6V RNA polymerase D3868_09430 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs D3868_09445 ENOG4105CDH Citrulline--aspartate ligase D3868_09460 ENOG4105KHC sulfurtransferase D3868_09470 ENOG4108SXK Transporter Drug Metabolite Exporter family D3868_09475 ENOG4106FI7 cytochrome c-type biogenesis protein D3868_09480 ENOG4105KWW Biogenesis protein D3868_09485 ENOG4107QX9 Thiol disulfide interChange protein D3868_09490 ENOG4105DA4 cytochrome c-type biogenesis protein D3868_09495 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) D3868_09505 ENOG41060IM Heme exporter protein D3868_09510 ENOG4105ETT transcriptional Regulator, LysR family D3868_09520 ENOG4105KJF protein tyrosine phosphatase D3868_09525 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) D3868_09530 ENOG4108RG0 uracil-dna glycosylase D3868_09540 ENOG4105KZX Pterin carbinolamine dehydratase D3868_09545 ENOG4107XWS modD protein D3868_09550 ENOG4107QUT magnesium and cobalt transport protein CorA D3868_09555 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) D3868_09560 ENOG410856B UPF0235 protein D3868_09595 ENOG4108JEH abc transporter atp-binding protein D3868_09605 ENOG4105D0C transport protein D3868_09610 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) D3868_09615 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) D3868_09620 ENOG4105K63 Thioredoxin D3868_09640 ENOG4108S0S Nucleotidyl transferase D3868_09650 ENOG4108E87 P-loop hydrolase UPF0079 D3868_09660 ENOG4105CAY ferredoxin--nadp reductase D3868_09670 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D3868_09675 ENOG4105E0F Histidine kinase D3868_09685 ENOG4105I8F Histidine kinase D3868_09690 ENOG4105BZU Histidine kinase D3868_09695 ENOG4107QXX ABC transporter D3868_09700 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) D3868_09705 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) D3868_09710 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) D3868_09715 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase D3868_09730 ENOG410642E Short chain dehydrogenase D3868_09745 ENOG4105BZU Histidine kinase D3868_09750 ENOG4105EUJ GTP cyclohydrolase i D3868_09760 ENOG4108Z66 YbaK ebsC protein D3868_09770 ENOG4105EUJ GTP cyclohydrolase i D3868_09775 ENOG4105NWN ApaG protein D3868_09810 ENOG4105C9U ATP-dependent DNA helicase RecQ D3868_09875 ENOG4105CFG Acts as a chaperone (By similarity) D3868_09880 ENOG4107QYX exodeoxyribonuclease v alpha D3868_09965 ENOG4108KU3 Integrase D3868_09985 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D3868_10000 ENOG4105BZU Histidine kinase D3868_10020 ENOG4108Z86 Glutamine amidotransferase D3868_10025 ENOG4105BZU Histidine kinase D3868_10035 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) D3868_10040 ENOG4108W2P Methyl-accepting chemotaxis D3868_10045 ENOG4108ZG0 Ompa motb domain protein D3868_10075 ENOG4105C0H protease D3868_10105 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) D3868_10110 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D3868_10115 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D3868_10125 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase D3868_10130 ENOG4105K9H YciI-like protein D3868_10145 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D3868_10165 ENOG4105D0M Protease HtpX homolog D3868_10180 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B D3868_10190 ENOG4105DC1 bifunctional purine biosynthesis protein purh D3868_10215 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D3868_10220 ENOG4105C7I Dehydrogenase D3868_10225 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D3868_10245 ENOG4108N2Y auxin Efflux D3868_10250 ENOG4105JSC dimethylmenaquinone methyltransferase D3868_10265 ENOG4105K63 Thioredoxin D3868_10270 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) D3868_10275 ENOG4105W49 UPF0434 protein D3868_10310 ENOG4105KT7 mgtC SapB transporter D3868_10315 ENOG4105C2C drug resistance transporter, Bcr CflA D3868_10325 ENOG4105BZU Histidine kinase D3868_10355 ENOG4108K3A Glutathione S-transferase D3868_10375 ENOG4105C1J atp-dependent rna helicase D3868_10380 ENOG41090R7 Ferric uptake D3868_10395 ENOG4105BZU Histidine kinase D3868_10405 ENOG41084GC stage II sporulation protein D3868_10435 ENOG4105BZU Histidine kinase D3868_10440 ENOG4105BZU Histidine kinase D3868_10450 ENOG41084GC stage II sporulation protein D3868_10460 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D3868_10465 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) D3868_10470 ENOG4105BZU Histidine kinase D3868_10475 ENOG4105C8Q Methyl-accepting chemotaxis D3868_10480 ENOG4108V3W Chemotaxis protein, CheW D3868_10485 ENOG4105CBS Chea signal transduction histidine kinase D3868_10500 ENOG4105BZU Histidine kinase D3868_10510 ENOG4108IRC dna polymerase iii D3868_10515 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D3868_10530 ENOG4107835 probably involved in intracellular septation (By similarity) D3868_10540 ENOG4105FYV Amp nucleosidase D3868_10545 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) D3868_10550 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) D3868_10555 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) D3868_10570 ENOG41089I4 Inherit from COG: Glycosyl transferase, family 2 D3868_10580 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D3868_10585 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D3868_10605 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) D3868_10610 ENOG4108URH decarboxylase D3868_10620 ENOG4105D6Z AFG1 family ATPase D3868_10625 ENOG4105BZU Histidine kinase D3868_10630 ENOG4105BZU Histidine kinase D3868_10635 ENOG4105C7S Dehydrogenase D3868_10650 ENOG4105CMV Succinyl-CoA synthetase subunit beta D3868_10655 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) D3868_10670 ENOG4105DK7 lysyl-tRNA synthetase D3868_10675 ENOG4105KPY Small multidrug resistance protein D3868_10685 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase D3868_10690 ENOG4105DVT helicase D3868_10705 ENOG4105CVG Homoserine O-transsuccinylase D3868_10730 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D3868_10735 ENOG4105K5X acetyltransferase D3868_10750 ENOG410612Q succinate dehydrogenase (cytochrome b-556 subunit) D3868_10765 ENOG4105E33 succinate dehydrogenase D3868_10860 ENOG4105DVH amino acid D3868_10880 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta D3868_10890 ENOG4105ETU transcriptional activator (TenA D3868_10895 ENOG4105M0C cytoplasmic protein D3868_10900 ENOG4108C33 Resolvase D3868_10905 ENOG4108ZXE D3868_10935 ENOG4105D5G Transposase D3868_10975 ENOG4107RTG Major Facilitator superfamily D3868_11035 ENOG4105BZU Histidine kinase D3868_11070 ENOG4105DDI hemolysin-type calcium-binding region D3868_11100 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) D3868_11110 ENOG4105C22 threonyL-tRNA synthetase D3868_11115 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) D3868_11120 ENOG4108JQC penicillin-binding protein 1A D3868_11165 ENOG4108VN5 Inherit from COG: PepSY-associated TM helix D3868_11190 ENOG4105ENH Sulfatase D3868_11225 ENOG4105C7R Atpase associated with various cellular activities aaa_3 D3868_11235 ENOG4105E6M Sulphatase-modifying factor protein D3868_11250 ENOG4108KAM Transcriptional regulator D3868_11255 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D3868_11260 ENOG4105E39 Enoyl-CoA hydratase D3868_11270 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D3868_11275 ENOG4105CHR reductase D3868_11285 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_11290 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D3868_11295 ENOG4105C0Z ABC transporter D3868_11300 ENOG4108IV0 ABC, transporter D3868_11325 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) D3868_11355 ENOG4108TF4 von Willebrand factor, type A D3868_11390 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) D3868_11425 ENOG4105C3M thioredoxin reductase D3868_11440 ENOG4108AWY Nucleoside-diphosphate-sugar epimerase D3868_11445 ENOG4105F7P transcriptional regulator AsnC family D3868_11455 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) D3868_11460 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain D3868_11505 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) D3868_11515 ENOG4105EIB trna rrna methyltransferase D3868_11520 ENOG4107JEE Short-chain dehydrogenase reductase Sdr D3868_11525 ENOG4108UM1 dedA family D3868_11535 ENOG4105G9V cytochrome C D3868_11540 ENOG4105F4R Transcriptional regulator mode D3868_11545 ENOG4105C26 Dehydrogenase D3868_11560 ENOG4105BZU Histidine kinase D3868_11570 ENOG4105DA5 (ABC) transporter D3868_11605 ENOG4105DZG Dehydrogenase D3868_11620 ENOG4105E2Y ABC, transporter D3868_11660 ENOG4108S0N Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) D3868_11675 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) D3868_11680 ENOG4105BZU Histidine kinase D3868_11690 ENOG4107QQR Sporulation D3868_11695 ENOG4105CYN Serine protein kinase D3868_11700 ENOG4106AKX UPF0229 protein D3868_11705 ENOG4105ED1 spovr family D3868_11720 ENOG4105CQ7 ATP-dependent helicase D3868_11745 ENOG4105ETX regulatoR D3868_11770 ENOG4107QX8 SPFH domain, Band 7 family protein D3868_11775 ENOG4105DSF transport protein D3868_11785 ENOG4108KK1 membrane protein AbrB duplication D3868_11790 ENOG4108Q6X Aspartoacylase (EC 3.5.1.15) D3868_11800 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) D3868_11820 ENOG4105BZU Histidine kinase D3868_11830 ENOG4105BZU Histidine kinase D3868_11850 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D3868_11860 ENOG41080XQ Signal transduction protein with cbs domains D3868_11890 ENOG4105WH1 Two component transcriptional regulator luxr family D3868_11895 ENOG4105WH1 Two component transcriptional regulator luxr family D3868_11915 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D3868_11925 ENOG4105DC7 peptidase M24 D3868_11925 ENOG4105DC7 peptidase M24 D3868_11930 ENOG4108VYJ response regulator receiver protein D3868_11945 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane D3868_11950 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) D3868_11970 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) D3868_11980 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D3868_11985 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) D3868_11990 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) D3868_11995 ENOG4108UFP Essential cell division protein (By similarity) D3868_12000 ENOG4105CPF Cell wall formation (By similarity) D3868_12005 ENOG4105D4A Cell wall formation (By similarity) D3868_12010 ENOG4105DFU Cell wall formation (By similarity) D3868_12020 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) D3868_12030 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) D3868_12035 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) D3868_12045 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) D3868_12060 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) D3868_12065 ENOG4107YUR Cell division protein mraZ D3868_12085 ENOG4105C5H ABC transporter D3868_12090 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) D3868_12105 ENOG4105CQB FAD linked oxidase domain protein D3868_12110 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D3868_12150 ENOG4105EAH synthase D3868_12180 ENOG4107QIB glycyl-tRNA synthetase, alpha subunit D3868_12185 ENOG4105C38 Glycyl-tRNA synthetase beta subunit D3868_12190 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) D3868_12195 ENOG41067MG lrgb family D3868_12200 ENOG4105VAW lrga family D3868_12205 ENOG4107XM9 (LipO)protein D3868_12230 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) D3868_12240 ENOG4105I8F Histidine kinase D3868_12270 ENOG4108E1C hydrolase D3868_12275 ENOG4105EAQ (twin-arginine translocation) pathway signal D3868_12315 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) D3868_12320 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein D3868_12325 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D3868_12330 ENOG41083KI ribonuclease, T2 D3868_12335 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) D3868_12355 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) D3868_12380 ENOG4105DZ1 carboxypeptidase D3868_12395 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) D3868_12400 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) D3868_12425 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D3868_12430 ENOG4105QAX Iron-sulfur D3868_12455 ENOG4107W7X Aldolase D3868_12460 ENOG4105BZU Histidine kinase D3868_12465 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b D3868_12470 ENOG4108505 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D3868_12475 ENOG4108VHN F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D3868_12485 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) D3868_12505 ENOG4105C8Q Methyl-accepting chemotaxis D3868_12510 ENOG4105C9A Phoh family D3868_12515 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) D3868_12520 ENOG4107QMS site-determining protein D3868_12525 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) D3868_12540 ENOG4105C8Q Methyl-accepting chemotaxis D3868_12550 ENOG4107S8C mandelate racemase muconate lactonizing D3868_12560 ENOG4105C3J Cysteine desulfurase D3868_12570 ENOG41090A4 Pterin carbinolamine dehydratase D3868_12580 ENOG4105CHC glucokinase (EC 2.7.1.2) D3868_12585 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase D3868_12600 ENOG4105C8Q Methyl-accepting chemotaxis D3868_12605 ENOG4105C8Q Methyl-accepting chemotaxis D3868_12610 ENOG4107QP3 malate synthase g D3868_12615 ENOG4105C7H Helicase, RecD TraA family D3868_12620 ENOG4105VEQ Cold shock protein D3868_12645 ENOG41090P5 ferredoxin-like protein D3868_12655 ENOG4105C10 Electron transfer flavoprotein D3868_12660 ENOG4105BZJ Electron transfer flavoprotein D3868_12705 ENOG4105WCA Ferredoxin D3868_12710 ENOG4105X87 nitrogen fixation D3868_12715 ENOG4108VQE nitrogen fixation protein D3868_12720 ENOG4108UR2 Nitrogen fixation protein NifX D3868_12725 ENOG4105DK8 Nitrogenase molybdenum-iron cofactor biosynthesis protein NifN D3868_12730 ENOG4105D0B Nitrogenase protein alpha chain D3868_12735 ENOG4107SDU Methyl-accepting chemotaxis D3868_12760 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) D3868_12770 ENOG4108K8Z nad( )--dinitrogen-reductase ADP-d-ribosyltransferase D3868_12775 ENOG41065RQ ADP-ribosylation crystallin J1 D3868_12780 ENOG4105ND9 Nitrogenase-associated protein D3868_12785 ENOG4105E7A Glutamine amidotransferase D3868_12790 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) D3868_12800 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D3868_12815 ENOG4105C3J Cysteine desulfurase D3868_12830 ENOG4108QWQ LRV FeS4 cluster domain protein D3868_12840 ENOG4107IVC 4Fe-4S ferredoxin, iron-sulfur binding D3868_12845 ENOG4105CGC Nitrogenase cofactor biosynthesis protein NifB D3868_12865 ENOG4108R86 Transcriptional regulator D3868_12875 ENOG4105CJ1 ABC, transporter D3868_12885 ENOG4107QWP ABC-2 type transporter D3868_12890 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) D3868_12900 ENOG4105YK5 50S ribosomal protein L36 D3868_12905 ENOG4105CQB FAD linked oxidase domain protein D3868_12910 ENOG4105EU8 FAD linked oxidase domain protein D3868_12915 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D3868_12920 ENOG4105VE1 Phosphatidylcholine synthase D3868_12935 ENOG4105CSU acyl-Coa dehydrogenase D3868_12950 ENOG4105CQB FAD linked oxidase domain protein D3868_12955 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) D3868_12960 ENOG4107QJE Chromosome Partitioning Protein D3868_12970 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D3868_12975 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) D3868_12985 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) D3868_12990 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) D3868_12995 ENOG4105DHZ alpha beta D3868_13000 ENOG4105D7W serine acetyltransferase D3868_13005 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family D3868_13015 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) D3868_13025 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) D3868_13045 ENOG4108JJ6 Type I secretion system ATPase D3868_13065 ENOG4105EMU Dehydrogenase D3868_13070 ENOG4105EQ2 LysR family Transcriptional regulator D3868_13075 ENOG4105DTA methyltransferase D3868_13085 ENOG4105BZU Histidine kinase D3868_13095 ENOG4108VYJ response regulator receiver protein D3868_13130 ENOG4105CVE Lytic murein transglycosylase D3868_13150 ENOG4105C0A alcohol dehydrogenase D3868_13170 ENOG4107T8Q Glycosyl transferase (Group 1 D3868_13180 ENOG4105KD7 acetyltransferase D3868_13195 ENOG4105C9Q fumarate hydratase class II D3868_13210 ENOG4105BZU Histidine kinase D3868_13215 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit D3868_13240 ENOG4108YYQ gCN5-related N-acetyltransferase D3868_13260 ENOG4107B2H carbonic anhydrase D3868_13310 ENOG4105II7 pyrroline-5-carboxylate reductase D3868_13320 ENOG4105CEY Amp-dependent synthetase and ligase D3868_13350 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) D3868_13355 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) D3868_13360 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) D3868_13365 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) D3868_13405 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D3868_13450 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D3868_13480 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D3868_13485 ENOG4105W8H transhydrogenase (subunit alpha D3868_13490 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D3868_13500 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) D3868_13505 ENOG4105K5G 30S ribosomal protein S21 D3868_13510 ENOG4108RBJ Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) D3868_13520 ENOG4105HP8 regulator of competence-specific genes D3868_13535 ENOG4107R2U Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) D3868_13560 ENOG4105C7J ABC transporter, permease D3868_13565 ENOG4108IV0 ABC, transporter D3868_13570 ENOG4105CKD glutathione-regulated potassium-efflux system protein D3868_13580 ENOG4107QJR hflk protein D3868_13585 ENOG4105EPW hflc protein D3868_13610 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) D3868_13615 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D3868_13620 ENOG4105C7K acetolactate synthase D3868_13630 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase D3868_13635 ENOG4108UTW Plays a role in the regulation of phosphate uptake D3868_13640 ENOG4108TEB UPF0114 protein D3868_13660 ENOG4105CJN penicillin-binding protein D3868_13680 ENOG4105DIH basic membrane D3868_13685 ENOG4108JQ9 ABC transporter D3868_13700 ENOG4105KG3 cytidine deaminase D3868_13705 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) D3868_13710 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) D3868_13725 ENOG4108EHX EamA-like transporter family D3868_13745 ENOG4105C0Z ABC transporter D3868_13750 ENOG4108IV0 ABC, transporter D3868_13765 ENOG4105CSR polyphosphate kinase 2 D3868_13770 ENOG4105CSR polyphosphate kinase 2 D3868_13775 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) D3868_13785 ENOG4108NJZ Sensory box GGDEF EAL domain protein D3868_13795 ENOG4108RAV Conserved protein D3868_13805 ENOG41074H6 response regulator D3868_13810 ENOG4105Y3U Transglycosylase-associated protein D3868_13815 ENOG4105DJV ribulose-phosphate 3-epimerase D3868_13820 ENOG4105F4R Transcriptional regulator mode D3868_13830 ENOG4105KVH Transcriptional regulator D3868_13840 ENOG4105ZXK Dehydrogenase D3868_13845 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D3868_13860 ENOG4107XGZ Hydrolase D3868_13875 ENOG4108RIR Molybdenum cofactor biosynthesis protein D3868_13885 ENOG4105WD1 Membrane D3868_13890 ENOG4105W39 Membrane D3868_13895 ENOG4105BZU Histidine kinase D3868_13900 ENOG4105CA9 Pyruvate kinase D3868_13905 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits D3868_13910 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) D3868_13915 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D3868_13920 ENOG4108ZT0 50S ribosomal protein l17 D3868_13925 ENOG4108UM1 dedA family D3868_13940 ENOG4105D1H recombination factor protein RarA D3868_13960 ENOG4105DRR Transcriptional regulator, GntR family D3868_13965 ENOG4105DKK Benzoate D3868_13970 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D3868_13995 ENOG4105NXH GreA GreB family elongation factor D3868_14000 ENOG4105C2J ABC transporter D3868_14005 ENOG4105UIB (ABC) transporter D3868_14040 ENOG4105BZU Histidine kinase D3868_14145 ENOG4105CVR type I restriction-modification system D3868_14215 ENOG4107MV2 Inherit from COG: Hemolysin-type calcium-binding D3868_14300 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D3868_14305 ENOG41069M3 Transcriptional regulator D3868_14310 ENOG4105CMT Dihydroxyacetone kinase D3868_14330 ENOG4105E7U AraC family transcriptional regulator D3868_14345 ENOG4105C1P efflux transporter, rnd family, mfp subunit D3868_14360 ENOG4105CPQ Dehydrogenase D3868_14365 ENOG4108ERU trap dicarboxylate transporter subunit DctP D3868_14375 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_14380 ENOG4105CTX dehydratase D3868_14385 ENOG4107QZW Altronate oxidoreductase D3868_14410 ENOG4105C4W S-formylglutathione hydrolase D3868_14420 ENOG4105CC0 LysR family Transcriptional regulator D3868_14425 ENOG41066VF YeeE YedE family protein D3868_14430 ENOG4105EEQ Na H antiporter D3868_14440 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_14445 ENOG4105E0C molybdate abc transporter D3868_14450 ENOG4105C4Y ABC transporter D3868_14465 ENOG4105DZ1 carboxypeptidase D3868_14490 ENOG4105BZU Histidine kinase D3868_14510 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) D3868_14540 ENOG4105CYM Glutathione S-transferase D3868_14545 ENOG4105DTD Dehydrogenase D3868_14550 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D3868_14560 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_14570 ENOG4108IV0 ABC, transporter D3868_14575 ENOG4105C0Z ABC transporter D3868_14610 ENOG4105QUC reductase D3868_14630 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) D3868_14640 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) D3868_14645 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase D3868_14650 ENOG4105F6U Short-chain dehydrogenase reductase Sdr D3868_14655 ENOG4108XFH Transcriptional regulator D3868_14660 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) D3868_14665 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D3868_14670 ENOG4105CGH 5'-nucleotidase D3868_14695 ENOG4105BZE flagellar hook protein, FlgE D3868_14730 ENOG4108IUZ ABC transporter D3868_14740 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_14745 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein D3868_14815 ENOG4105BZJ Electron transfer flavoprotein D3868_14820 ENOG4105C10 Electron transfer flavoprotein D3868_14825 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D3868_14835 ENOG4107ZT5 Thiol disulfide interchange protein D3868_14840 ENOG4105CH7 arginosuccinase D3868_14870 ENOG4105CNI cell division protein FtsW D3868_14880 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D3868_14905 ENOG4108TPP exopolysaccharide synthesis D3868_14910 ENOG4105C08 Histidine kinase D3868_14920 ENOG4108VYJ response regulator receiver protein D3868_14925 ENOG4108R7K Metal Dependent Phosphohydrolase D3868_14975 ENOG4105C7W Xanthine dehydrogenase D3868_14980 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding D3868_14985 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit D3868_14990 ENOG4106P55 Transcriptional regulator D3868_15005 ENOG4108M9J MaoC like domain protein D3868_15010 ENOG4105CI0 Citrate lyase D3868_15015 ENOG4105C1G acyl-Coa dehydrogenase D3868_15055 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) D3868_15080 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) D3868_15085 ENOG4105BZU Histidine kinase D3868_15090 ENOG4108ZZA carbonate dehydratase activity D3868_15100 ENOG4105CMJ mandelate racemase muconate lactonizing D3868_15105 ENOG4107YNJ LysR family Transcriptional regulator D3868_15110 ENOG4108N27 Glutathione S-transferase D3868_15175 ENOG4105CHJ isochorismatase hydrolase D3868_15180 ENOG4105BZU Histidine kinase D3868_15185 ENOG4108ZXC Two component transcriptional regulator, luxr family D3868_15195 ENOG4105BZU Histidine kinase D3868_15205 ENOG4105CE1 Ferrous iron transport protein b D3868_15225 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) D3868_15230 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D3868_15235 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D3868_15255 ENOG4105BZ1 (ABC) transporter D3868_15260 ENOG4105S6R Iron-hydroxamate transporter permease subunit D3868_15270 ENOG4105E0A ABC, transporter D3868_15275 ENOG4105E0K tonB-dependent siderophore receptor D3868_15290 ENOG4105C0R drug resistance transporter emrb qaca subfamily D3868_15365 ENOG4105E5Q amino acid AbC transporter D3868_15395 ENOG4105VCD cytoplasmic protein D3868_15400 ENOG4105D22 carbon starvation protein D3868_15435 ENOG4105EMU Dehydrogenase D3868_15450 ENOG4105E39 Enoyl-CoA hydratase D3868_15480 ENOG4108IJ9 (ABC) transporter D3868_15495 ENOG4108JJA ABC, transporter D3868_15500 ENOG4107QZV Type I secretion membrane fusion protein D3868_15505 ENOG4105CP9 extracellular ligand-binding receptor D3868_15540 ENOG4105IBP Cyclic peptide transporter D3868_15550 ENOG4105IBP Cyclic peptide transporter D3868_15580 ENOG4105KJM monovalent cation h antiporter subunit g D3868_15585 ENOG4105W4C monovalent cation H antiporter subunit F D3868_15590 ENOG4105SC1 monovalent cation H antiporter subunit E D3868_15595 ENOG4107R4Z monovalent cation h antiporter subunit d D3868_15600 ENOG4108ZE9 Monovalent cation H antiporter subunit C D3868_15605 ENOG4105D65 subunit l D3868_15610 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN D3868_15615 ENOG4108JQ1 Dehydrogenase D3868_15620 ENOG4105C8V SAICAR synthetase D3868_15635 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family D3868_15640 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) D3868_15645 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) D3868_15665 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) D3868_15675 ENOG4105BZU Histidine kinase D3868_15685 ENOG4105C8Q Methyl-accepting chemotaxis D3868_15690 ENOG4105CBS Chea signal transduction histidine kinase D3868_15695 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D3868_15700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D3868_15705 ENOG4105BZU Histidine kinase D3868_15710 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) D3868_15715 ENOG4108MG3 formate dehydrogenase D3868_15720 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D3868_15725 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D3868_15730 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) D3868_15745 ENOG4105MP9 class II Aldolase D3868_15750 ENOG41084KP 4-oxalocrotonate tautomerase D3868_15790 ENOG4107RH8 nuclease SbcCD subunit D D3868_15795 ENOG4105EYH Exonuclease D3868_15800 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases D3868_15810 ENOG4107QJE Chromosome Partitioning Protein D3868_15815 ENOG4105FA0 parb-like partition protein D3868_15830 ENOG410642W LysR family Transcriptional regulator D3868_15835 ENOG4108UQ8 endoribonuclease L-psp D3868_15855 ENOG4105D7T ABC transporter D3868_15865 ENOG4105I5W Transporter D3868_15870 ENOG4108IFG nitrite reductase, (NAD(P)H) D3868_15875 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit D3868_15885 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) D3868_15890 ENOG4107SN7 NLP P60 protein D3868_15900 ENOG4105CCT upf0313 protein D3868_15945 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) D3868_15950 ENOG4105DIQ Transcriptional regulator D3868_15955 ENOG4105CR8 Transcriptional regulator D3868_15965 ENOG4105VT2 5-hydroxyisourate hydrolase D3868_15970 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) D3868_15980 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) D3868_15985 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D3868_15995 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase D3868_16000 ENOG4108EU5 L-aspartate oxidase D3868_16040 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D3868_16045 ENOG4105QAX Iron-sulfur D3868_16050 ENOG4108MG3 formate dehydrogenase D3868_16055 ENOG4107S4Y M20 DapE family protein YgeY D3868_16080 ENOG4108I05 Binding-protein-dependent transport systems, inner membrane component D3868_16090 ENOG4105CHR reductase D3868_16120 ENOG4105XJC Two component transcriptional regulator (Winged helix family D3868_16125 ENOG41062D9 Histidine kinase D3868_16175 ENOG4106UW1 Major Facilitator superfamily D3868_16195 ENOG4105C2X Arabinose 5-phosphate isomerase D3868_16210 ENOG4108IUZ ABC transporter D3868_16215 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3868_16220 ENOG4107TNS sigma 54 modulation protein ribosomal protein S30ea D3868_16225 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN D3868_16230 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D3868_16235 ENOG4105CFH Aspartokinase D3868_16245 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase D3868_16255 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) D3868_16260 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) D3868_16265 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) D3868_16270 ENOG4105WDY DNA (cytosine-5-)-methyltransferase D3868_16275 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) D3868_16295 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D3868_16300 ENOG4108UT2 hemolysin iii D3868_16305 ENOG4108UMN azlc family D3868_16325 ENOG4108JJ7 ABC transporter D3868_16335 ENOG4105DJT lAO AO transport system ATPase D3868_16345 ENOG4105KDC 50s ribosomal protein l28 D3868_16355 ENOG4105GB5 regulatory protein RecX D3868_16360 ENOG4105E3A (ABC) transporter D3868_16365 ENOG4105C8Y Acetylornithine aminotransferase D3868_16370 ENOG4105DBV ornithine carbamoyltransferase D3868_16375 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) D3868_16385 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) D3868_16390 ENOG410841Q phosphoesterase PA-phosphatase related protein D3868_16405 ENOG4107QYG anthranilate phosphoribosyltransferase D3868_16410 ENOG4108ESX Receptor D3868_16415 ENOG4107E2E PKHD-type hydroxylase D3868_16430 ENOG4108IPW abc transporter atp-binding protein D3868_16435 ENOG4105CM4 permease protein D3868_16440 ENOG4105DHS permease protein D3868_16450 ENOG4105NTW Transcriptional regulator D3868_16465 ENOG4105BZU Histidine kinase D3868_16470 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D3868_16525 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) D3868_16540 ENOG4105DU1 integral membrane protein, terc D3868_16575 ENOG4108Z9Z response to DNA damage stimulus D3868_16610 ENOG4105CH5 extracellular solute-binding protein, family 7 D3868_16620 ENOG4105C5X domain protein D3868_16625 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family D3868_16635 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein D3868_16640 ENOG4108I5D sulfate abc transporter D3868_16650 ENOG4108IJ6 ABC transporter D3868_16700 ENOG4105CAQ asparagine synthetase D3868_16705 ENOG4105CEY Amp-dependent synthetase and ligase D3868_16730 ENOG4105CG5 Glycosyl transferase (Group 1 D3868_16745 ENOG4105D3Q Sugar transferase D3868_16755 ENOG4106R7G Glycoside hydrolase family 5 D3868_16765 ENOG4105D9F endo-1,4-beta-xylanase (EC 3.2.1.8) D3868_16775 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family D3868_16785 ENOG4105CB5 ATP-dependent DNA helicase recG D3868_16790 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) D3868_16815 ENOG4105ES5 Histidine kinase D3868_16825 ENOG4105D01 (LipO)protein D3868_16830 ENOG4108UMI ABC transporter, permease D3868_16835 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) D3868_16840 ENOG4105CEY Amp-dependent synthetase and ligase D3868_16845 ENOG4105D01 (LipO)protein D3868_16855 ENOG4107VBH Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) D3868_16860 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) D3868_16865 ENOG4108ZTZ UPF0262 protein D3868_16870 ENOG4108UXE Protein tyrosine phosphatase D3868_16875 ENOG4105BZU Histidine kinase D3868_16885 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) D3868_16890 ENOG4108Z03 MAF-like protein D3868_16895 ENOG4105C03 ribonuclease D3868_16900 ENOG4105VYE Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) D3868_16930 ENOG4107QJE Chromosome Partitioning Protein D3868_16945 ENOG4105C8Y Acetylornithine aminotransferase D3868_16960 ENOG4108IG5 Transcriptional regulator D3868_16975 ENOG4105KCV RNA signal recognition particle 4.5S RNA D3868_16985 ENOG4108JPW Aminotransferase D3868_16990 ENOG4105C26 Dehydrogenase D3868_16995 ENOG4107VRI Transcriptional regulator D3868_17005 ENOG4105F38 ABC transporter, permease D3868_17010 ENOG4107FKK extracellular solute-binding protein family 1 D3868_17015 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_17020 ENOG4106NZI LysR family Transcriptional regulator D3868_17025 ENOG4105C1G acyl-Coa dehydrogenase D3868_17030 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D3868_17065 ENOG4105CV8 reductase D3868_17070 ENOG4105F27 Major Facilitator D3868_17075 ENOG4105HEI LysR family (Transcriptional regulator D3868_17085 ENOG4105Y49 secretion protein, HlyD family D3868_17090 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) D3868_17095 ENOG4105ZQC membrane protein AaeX D3868_17125 ENOG4105MQ2 17 kDa surface antigen D3868_17140 ENOG4108IV0 ABC, transporter D3868_17145 ENOG4105VUF Transcriptional regulator D3868_17150 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase D3868_17160 ENOG4105EN6 Membrane D3868_17190 ENOG4105C59 p-type ATPase D3868_17205 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) D3868_17220 ENOG4108RIR Molybdenum cofactor biosynthesis protein D3868_17225 ENOG4105E4C Lytic transglycosylase catalytic D3868_17230 ENOG4108UN4 phage SPO1 DNA polymerase-related protein D3868_17235 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase D3868_17255 ENOG4105DS0 Transcriptional regulator, Crp Fnr family D3868_17305 ENOG4105MQ2 17 kDa surface antigen D3868_17320 ENOG4105C8Q Methyl-accepting chemotaxis D3868_17340 ENOG41090R7 Ferric uptake D3868_17360 ENOG4105BZU Histidine kinase D3868_17380 ENOG4105EAM Na Pi-cotransporter D3868_17405 ENOG4105IJJ transcriptional regulator, crp fnr family D3868_17430 ENOG4105F8J Adenylate Guanylate cyclase D3868_17440 ENOG4107QXV Phosphate transporter D3868_17445 ENOG4107GRR phosphate transport regulator D3868_17455 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) D3868_17465 ENOG4105EU0 Major facilitator Superfamily D3868_17475 ENOG4107QIJ Aconitate hydratase 2 D3868_17500 ENOG4105C1V Peptidase, M16 D3868_17510 ENOG4108NH8 Cation transport protein D3868_17530 ENOG4105CH5 extracellular solute-binding protein, family 7 D3868_17540 ENOG4105C5H ABC transporter D3868_17555 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF D3868_17560 ENOG4105HEI LysR family (Transcriptional regulator D3868_17565 ENOG4105DKK Benzoate D3868_17575 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D3868_17580 ENOG4108KF1 Membrane D3868_17615 ENOG4105CAK Cell division ATP-binding protein ftsE D3868_17625 ENOG4108IG5 Transcriptional regulator D3868_17660 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D3868_17665 ENOG4105CH5 extracellular solute-binding protein, family 7 D3868_17670 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_17680 ENOG4105DWA May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate D3868_17695 ENOG4105ER2 Ompa motb domain protein D3868_17705 ENOG4105C7B Threonine dehydratase D3868_17730 ENOG4105CBS Chea signal transduction histidine kinase D3868_17735 ENOG4105YFD chemotaxis, protein D3868_17740 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D3868_17750 ENOG4105BZU Histidine kinase D3868_17755 ENOG4105ETT transcriptional Regulator, LysR family D3868_17765 ENOG4105EFQ Two component transcriptional regulator (Winged helix family D3868_17770 ENOG4108JIR Flagellum-specific ATP synthase D3868_17780 ENOG4105BZU Histidine kinase D3868_17785 ENOG4107YRI Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) D3868_17795 ENOG4107R21 site-determining protein D3868_17800 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) D3868_17805 ENOG4105D7B Flagellar biosynthesis protein flha D3868_17810 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D3868_17815 ENOG4105E14 MotA TolQ exbB proton channel D3868_17820 ENOG4105DD5 Flagellar motor switch protein D3868_17830 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) D3868_17835 ENOG4108WRK Transcriptional regulator D3868_17845 ENOG4105BZU Histidine kinase D3868_17850 ENOG4105DN3 alpha-2-macroglobulin domain protein D3868_17865 ENOG4105CHU acetyl-coa acetyltransferase D3868_17875 ENOG4105CSU acyl-Coa dehydrogenase D3868_17900 ENOG4105FC8 fad dependent oxidoreductase D3868_17905 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) D3868_17920 ENOG4105CEN a g-specific adenine glycosylase D3868_17945 ENOG4105CEC DNA methylase N-4 N-6 D3868_17950 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) D3868_17955 ENOG410870F Cyclic nucleotide-binding protein D3868_17960 ENOG4105K5B UPF0225 protein D3868_17965 ENOG4105VEQ Cold shock protein D3868_17970 ENOG4105CN1 protease D3868_17975 ENOG4105D3Q Sugar transferase D3868_18000 ENOG4107RSS Hydrogenase accessory protein HypB D3868_18005 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) D3868_18020 ENOG4105X9Y Hydrogenase assembly chaperone hypC hupF D3868_18040 ENOG4105CY0 Metallo-Beta-Lactamase D3868_18045 ENOG4108USZ hydrogenase D3868_18050 ENOG4105DPX Hydrogenase, large subunit D3868_18055 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit D3868_18060 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D3868_18065 ENOG4105E3S small subunit D3868_18080 ENOG4105CPN adenine deaminase D3868_18110 ENOG4108U78 Glutathione S-transferase D3868_18115 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) D3868_18135 ENOG4105DWV Homoserine O-trans-acetylase D3868_18140 ENOG4105DWV Homoserine O-trans-acetylase D3868_18150 ENOG4105CIH Imidazole acetol-phosphate transaminase D3868_18160 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein D3868_18170 ENOG4105C5Q Transcriptional regulator D3868_18175 ENOG4105D3R alkyl hydroperoxide reductase D3868_18180 ENOG4108JU3 Alkyl hydroperoxide reductase D3868_18185 ENOG4105C7W Xanthine dehydrogenase D3868_18190 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding D3868_18195 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit D3868_18205 ENOG4107K5X Membrane-bound metal-dependent hydrolase D3868_18215 ENOG4105K8K Cupin 2, conserved barrel D3868_18225 ENOG4105ETX regulatoR D3868_18230 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) D3868_18235 ENOG4105CD3 dihydroorotase D3868_18240 ENOG4105CXT aspartate transcarbamylase D3868_18255 ENOG4105ETT transcriptional Regulator, LysR family D3868_18285 ENOG4107ZJC Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) D3868_18295 ENOG41080G2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) D3868_18300 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D3868_18305 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) D3868_18350 ENOG4107QX3 carboxylase D3868_18360 ENOG4105VKD bioY protein D3868_18390 ENOG4105CK2 sodium dicarboxylate symporter D3868_18395 ENOG4105C6K Malic enzyme D3868_18400 ENOG4105RQ9 TPR repeat-containing protein D3868_18410 ENOG4105F1S paraquat-inducible protein a D3868_18415 ENOG4105DY2 Paraquat-inducible protein b D3868_18425 ENOG4105C6N Formate acetyltransferase D3868_18430 ENOG4108JUA Transcriptional regulator D3868_18435 ENOG4105K6V RNA polymerase D3868_18440 ENOG4108NIX Factor ChrR D3868_18445 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D3868_18465 ENOG4105CS6 Rhs element vgr protein D3868_18470 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D3868_18575 ENOG4108TEB UPF0114 protein D3868_18590 ENOG4105F4R Transcriptional regulator mode D3868_18595 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein D3868_18600 ENOG4105E0C molybdate abc transporter D3868_18605 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) D3868_18660 ENOG4105BZU Histidine kinase D3868_18670 ENOG4107QK4 glycoside hydrolase, family 3 domain protein D3868_18695 ENOG4107S9D Alpha beta hydrolase D3868_18710 ENOG4105C0A alcohol dehydrogenase D3868_18715 ENOG4105CH5 extracellular solute-binding protein, family 7 D3868_18725 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_18745 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) D3868_18770 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) D3868_18780 ENOG4108JEZ rRNA small subunit methyltransferase G D3868_18790 ENOG4105XDF Protein of unknown function (DUF1272) D3868_18800 ENOG4105CA3 membrane-bound lytic murein transglycosylase D3868_18805 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B D3868_18825 ENOG4105VRR gCN5-related N-acetyltransferase D3868_18830 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) D3868_18845 ENOG4105D5G Transposase D3868_18855 ENOG4108PTX LysR family Transcriptional regulator D3868_18875 ENOG4108FN7 Aldo keto reductase D3868_18880 ENOG410642W LysR family Transcriptional regulator D3868_18935 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) D3868_18945 ENOG4105DHJ ABC, transporter D3868_18965 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3868_18970 ENOG4105C4M (Ubiquinol oxidase) subunit I D3868_18975 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D3868_19005 ENOG41061TZ Short-chain dehydrogenase reductase Sdr D3868_19035 ENOG4107TY6 Acylneuraminate cytidylyltransferase D3868_19045 ENOG4108EMS branched-chain alpha-keto acid dehydrogenase subunit E2 D3868_19060 ENOG4105CHR reductase D3868_19065 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) D3868_19085 ENOG4105RQ9 TPR repeat-containing protein D3868_19100 ENOG4105RQ9 TPR repeat-containing protein D3868_19115 ENOG41082WC Transport-associated protein D3868_19120 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase D3868_19150 ENOG41074H6 response regulator D3868_19180 ENOG4108SM1 rRNA (Adenine-N(6)-)-methyltransferase D3868_19190 ENOG4105CI2 imidazolone-5-propionate hydrolase D3868_19205 ENOG4105CGP Urocanate hydratase D3868_19220 ENOG4105F2W methyltransferase D3868_19235 ENOG4105DEF Extracellular solute-binding protein, family 5 D3868_19240 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D3868_19245 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D3868_19250 ENOG4105C3U ABC transporter D3868_19255 ENOG4108JQ7 (ABC) transporter D3868_19290 ENOG4108VPT UPF0234 protein D3868_19310 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D3868_19320 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) D3868_19345 ENOG4105D78 K07001 NTE family protein D3868_19350 ENOG4105BZ1 (ABC) transporter D3868_19355 ENOG4105BZU Histidine kinase D3868_19380 ENOG4105D6S protein involved in catabolism of external DNA D3868_19390 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) D3868_19395 ENOG4105CC0 LysR family Transcriptional regulator D3868_19400 ENOG4105CS1 NAD(P)H quinone oxidoreductase D3868_19405 ENOG4105CHF Glutathione S-transferase D3868_19415 ENOG4105WH1 Two component transcriptional regulator luxr family D3868_19425 ENOG4105C3M thioredoxin reductase D3868_19445 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) D3868_19455 ENOG4105D0M Protease HtpX homolog D3868_19465 ENOG4105DS1 cytochrome b561 D3868_19485 ENOG4108Q71 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) D3868_19495 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) D3868_19515 ENOG4105RAK Histidine kinase D3868_19530 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) D3868_19545 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) D3868_19550 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) D3868_19555 ENOG4105C3F Signal peptidase i D3868_19560 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) D3868_19565 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) D3868_19575 ENOG4106K28 UPF0283 membrane protein D3868_19595 ENOG4108S10 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) D3868_19600 ENOG4105K64 Glycosyl transferase, family 2 D3868_19605 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) D3868_19610 ENOG4105Y49 secretion protein, HlyD family D3868_19615 ENOG4105BZS acriflavin resistance protein D3868_19625 ENOG4105NPQ Pfam:DUF403 D3868_19650 ENOG4108N2V aldose 1-epimerase D3868_19655 ENOG4105D9P serine threonine protein kinase D3868_19660 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) D3868_19690 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) D3868_19700 ENOG4105C1J atp-dependent rna helicase D3868_19710 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) D3868_19720 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D3868_19730 ENOG4106ABQ septum formation initiator D3868_19735 ENOG4108JYK Dehydrogenase D3868_19740 ENOG4105CPP Dehydrogenase, E1 component D3868_19745 ENOG4105C7S Dehydrogenase D3868_19750 ENOG4107QN2 dihydrolipoyl dehydrogenase D3868_19755 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) D3868_19760 ENOG4108Z1B Cyclase dehydrase D3868_19765 ENOG4107TH8 cina domain protein D3868_19770 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) D3868_19800 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D3868_19810 ENOG4105C1A potassium transporter peripheral membrane D3868_19815 ENOG4105F0I Aminotransferase D3868_19825 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) D3868_19830 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) D3868_19845 ENOG4105ECY inositol monophosphatase D3868_19860 ENOG4105DXN mazG family D3868_19865 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit D3868_19870 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D3868_19875 ENOG4108JPZ Monovalent cation H antiporter subunit D D3868_19885 ENOG4107TDF Formate hydrogenlyase subunit 4 D3868_19890 ENOG4108JPZ Monovalent cation H antiporter subunit D D3868_19900 ENOG4105BZM domain protein D3868_19905 ENOG4105BZU Histidine kinase D3868_19910 ENOG4105CCF Lysine exporter protein (Lyse ygga) D3868_19940 ENOG4105K8R UPF0145 protein D3868_19945 ENOG4105DWV Homoserine O-trans-acetylase D3868_19955 ENOG4108UXN response regulator D3868_19965 ENOG4107MKT Stringent starvation protein a D3868_19970 ENOG4105CH5 extracellular solute-binding protein, family 7 D3868_19975 ENOG4105CG3 alpha amylase, catalytic region D3868_19995 ENOG4105C8Q Methyl-accepting chemotaxis D3868_20030 ENOG4105BZS acriflavin resistance protein D3868_20035 ENOG4105ENT Efflux transporter rnd family, mfp subunit D3868_20040 ENOG4105EGI Transcriptional regulator D3868_20045 ENOG4105CFM UPF0317 protein D3868_20060 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_20065 ENOG4105P4J Allophanate hydrolase, subunit 1 D3868_20075 ENOG4105E7W lamb ycsf family protein D3868_20090 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) D3868_20105 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) D3868_20160 ENOG4105EWM Histidine kinase D3868_20165 ENOG4105ETX regulatoR D3868_20205 ENOG4105C3K feS assembly ATPase SufC D3868_20215 ENOG4105C9B Cysteine desulfurase D3868_20220 ENOG4108UNV SUF system FeS assembly protein, NifU family D3868_20230 ENOG4108Z4V iron-sulfur cluster assembly D3868_20240 ENOG4105CD8 aminopeptidase N D3868_20260 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase D3868_20295 ENOG4108Q71 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) D3868_20300 ENOG4108SXK Transporter Drug Metabolite Exporter family D3868_20305 ENOG4105BZU Histidine kinase D3868_20310 ENOG4105CZQ inner membrane transport protein YdhC D3868_20315 ENOG4105C5Q Transcriptional regulator D3868_20325 ENOG4107QIZ NADH dehydrogenase D3868_20330 ENOG4108IEG Formate dehydrogenase Alpha subunit D3868_20335 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) D3868_20350 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) D3868_20355 ENOG4108Z7R Chaperone CsaA D3868_20375 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) D3868_20385 ENOG4105C01 Dihydroxy-acid dehydratase D3868_20420 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) D3868_20425 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D3868_20430 ENOG4107QI1 Mate efflux family protein D3868_20465 ENOG4108UUM single-stranded DNA-binding protein D3868_20470 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D3868_20490 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) D3868_20510 ENOG4105FE1 phytoene synthase D3868_20525 ENOG4108UIV Protein of unknown function (DUF498/DUF598) D3868_20555 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) D3868_20560 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) D3868_20565 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) D3868_20570 ENOG4105BZU Histidine kinase D3868_20575 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) D3868_20580 ENOG41081BE Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) D3868_20585 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D3868_20590 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_20595 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) D3868_20600 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) D3868_20605 ENOG4108Z4T Peptidase M50 D3868_20610 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) D3868_20620 ENOG4105C75 arginyL-tRNA synthetase D3868_20625 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein D3868_20630 ENOG4108YX9 iron--sulfur cluster insertion protein erpA D3868_20635 ENOG4105CGK Exodeoxyribonuclease III D3868_20650 ENOG4105BZU Histidine kinase D3868_20655 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D3868_20660 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D3868_20665 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein D3868_20670 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) D3868_20690 ENOG4108IV0 ABC, transporter D3868_20695 ENOG4105C0Z ABC transporter D3868_20700 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D3868_20705 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_20710 ENOG41083Z3 extracellular ligand-binding receptor D3868_20715 ENOG4105FDP GntR family transcriptional regulator D3868_20720 ENOG41080ZP deoxycytidine triphosphate deaminase D3868_20740 ENOG4107JEE Short-chain dehydrogenase reductase Sdr D3868_20760 ENOG4105CVM Molybdenum cofactor synthesis domain protein D3868_20765 ENOG4105DRP amino acid AbC transporter D3868_20770 ENOG4105E5Q amino acid AbC transporter D3868_20775 ENOG4105EAB amino acid AbC transporter D3868_20780 ENOG4105CDA abc transporter atp-binding protein D3868_20785 ENOG4105C5I Dehydrogenase D3868_20790 ENOG4107P2S Transcriptional regulator D3868_20800 ENOG4105C01 Dihydroxy-acid dehydratase D3868_20805 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family D3868_20810 ENOG4105DIQ Transcriptional regulator D3868_20815 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) D3868_20820 ENOG4105E39 Enoyl-CoA hydratase D3868_20835 ENOG4109066 lysm domain bon superfamily protein D3868_20845 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component D3868_20850 ENOG4108IJ8 ABC transporter D3868_20855 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component D3868_20860 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system D3868_20865 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) D3868_20875 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_20885 ENOG4105F38 ABC transporter, permease D3868_20890 ENOG4105E2Z phosphate ABC transporter (Permease D3868_20895 ENOG410633P Hydantoin racemase D3868_20925 ENOG4106WF9 DNA-binding transcriptional regulator TorR D3868_20930 ENOG4105BZU Histidine kinase D3868_20965 ENOG4105C0R drug resistance transporter emrb qaca subfamily D3868_20985 ENOG4105C79 DNA protecting protein DprA D3868_21005 ENOG4105ERH Fumarylacetoacetate hydrolase D3868_21015 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D3868_21020 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_21025 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter D3868_21030 ENOG4105CHC glucokinase (EC 2.7.1.2) D3868_21035 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D3868_21050 ENOG41083G8 Multidrug resistance protein MdtM D3868_21060 ENOG4105EGS Mechanosensitive ion channel D3868_21110 ENOG4105C5I Dehydrogenase D3868_21115 ENOG4105DG4 malate L-lactate dehydrogenase D3868_21125 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component D3868_21145 ENOG4107SFQ iron-sulfur binding D3868_21190 ENOG4105CCU oxidase (Subunit III) D3868_21240 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D3868_21295 ENOG4105EQN UPF0261 protein D3868_21330 ENOG4108JA2 transcriptioN-repair coupling factor D3868_21355 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) D3868_21360 ENOG4105CN1 protease D3868_21365 ENOG4105W0E 50S ribosomal protein L33 D3868_21370 ENOG4105BZU Histidine kinase D3868_21375 ENOG4108UXN response regulator D3868_21380 ENOG4105BZU Histidine kinase D3868_21385 ENOG4105BZU Histidine kinase D3868_21405 ENOG4105C9M aspartyl-trna synthetase D3868_21410 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) D3868_21420 ENOG4107R33 ppx gppa phosphatase D3868_21425 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) D3868_21435 ENOG4105I7R Adenylate cyclase D3868_21440 ENOG4105CHR reductase D3868_21450 ENOG4105C02 permease D3868_21455 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase D3868_21465 ENOG4105CXB phosphoribosylaminoimidazole synthetase D3868_21470 ENOG4108V3E phosphoribosylglycinamide formyltransferase D3868_21485 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) D3868_21490 ENOG4105C5H ABC transporter D3868_21495 ENOG4108TPP exopolysaccharide synthesis D3868_21500 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) D3868_21505 ENOG4107FW0 short-chain dehydrogenase reductase D3868_21510 ENOG4105DSJ YicC domain protein D3868_21515 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) D3868_21520 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) D3868_21535 ENOG4105E4C Lytic transglycosylase catalytic D3868_21550 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) D3868_21555 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) D3868_21565 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) D3868_21575 ENOG4105BZU Histidine kinase D3868_21595 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) D3868_21615 ENOG41090HR transcriptional regulator D3868_21625 ENOG4105BZU Histidine kinase D3868_21630 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D3868_21635 ENOG4105E0F Histidine kinase D3868_21665 ENOG4108IV0 ABC, transporter D3868_21670 ENOG4105C0Z ABC transporter D3868_21675 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_21705 ENOG4105CHU acetyl-coa acetyltransferase D3868_21715 ENOG4107TTA Xylose isomerase domain protein TIM barrel D3868_21735 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_21740 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr D3868_21750 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) D3868_21755 ENOG4105CHR reductase D3868_21760 ENOG4107TTQ Alpha beta hydrolase fold D3868_21765 ENOG4105CPP Dehydrogenase, E1 component D3868_21770 ENOG4107R0V Pyruvate dehydrogenase D3868_21775 ENOG4106Z86 ATP-nad acox kinase D3868_21780 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family D3868_21830 ENOG4108IXY short-chain dehydrogenase reductase D3868_21845 ENOG4105DUM transcriptional regulator, lysR family D3868_21865 ENOG4105K56 Transcriptional regulator D3868_21870 ENOG4105CHR reductase D3868_21880 ENOG410642W LysR family Transcriptional regulator D3868_21895 ENOG4105DX0 Hemolysin A D3868_21905 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) D3868_21915 ENOG41083BM Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) D3868_21920 ENOG4105DGU Histone deacetylase D3868_21925 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) D3868_21935 ENOG41080HT Transcriptional regulator, arsr family D3868_21945 ENOG4105BZU Histidine kinase D3868_21955 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) D3868_21960 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) D3868_21965 ENOG4108R5F Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) D3868_21970 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) D3868_21975 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) D3868_21980 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate D3868_21990 ENOG4105P8F nudix hydrolase D3868_22000 ENOG4105C7R Atpase associated with various cellular activities aaa_3 D3868_22105 ENOG4105C1G acyl-Coa dehydrogenase D3868_22110 ENOG410609C Acyl carrier protein D3868_22115 ENOG4108Z9K Osmotically inducible protein D3868_22160 ENOG4105CHR reductase D3868_22185 ENOG4105HEI LysR family (Transcriptional regulator D3868_22195 ENOG4105CV6 ABC transporter, permease D3868_22215 ENOG4108UN4 phage SPO1 DNA polymerase-related protein D3868_22235 ENOG4105DZG Dehydrogenase D3868_22240 ENOG4105WJN methanol dehydrogenase-like protein, cytochrome cL (XoxG) D3868_22280 ENOG4105I9Z UPF0264 protein D3868_22300 ENOG4105CJ1 ABC, transporter D3868_22320 ENOG4105FIE Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) (By similarity) D3868_22325 ENOG4105DCC Formylmethanofuran dehydrogenase subunit A D3868_22335 ENOG4108ZCD Transcriptional coactivator pterin dehydratase D3868_22345 ENOG4108M6X Dehydrogenase D3868_22355 ENOG41068T5 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT (By similarity) D3868_22360 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) D3868_22370 ENOG4108P4C Formaldehyde-activating enzyme D3868_22465 ENOG4107HP6 Transcriptional regulator D3868_22470 ENOG4105E39 Enoyl-CoA hydratase D3868_22480 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_22485 ENOG4105F38 ABC transporter, permease D3868_22490 ENOG4105CEY Amp-dependent synthetase and ligase D3868_22520 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) D3868_22530 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D3868_22550 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_22555 ENOG4107RUE extracellular solute-binding protein family 1 D3868_22560 ENOG4105F38 ABC transporter, permease D3868_22570 ENOG4105VT2 5-hydroxyisourate hydrolase D3868_22580 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D3868_22585 ENOG4105BZU Histidine kinase D3868_22620 ENOG4105BZP glycoside hydrolase 15-related D3868_22635 ENOG4105WH1 Two component transcriptional regulator luxr family D3868_22640 ENOG4105WH1 Two component transcriptional regulator luxr family D3868_22655 ENOG4105C6Y Udp-glucose 6-dehydrogenase D3868_22660 ENOG4105C1B dTDP-glucose 4-6-dehydratase D3868_22665 ENOG4108IAJ Nad-dependent epimerase dehydratase D3868_22670 ENOG4105CPK Glycosyl transferase (Group 1 D3868_22675 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family D3868_22690 ENOG4108IAJ Nad-dependent epimerase dehydratase D3868_22710 ENOG4108MJN Glycosyl Transferase D3868_22725 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D3868_22740 ENOG4108KB2 LysR family Transcriptional regulator D3868_22745 ENOG4107S4Y M20 DapE family protein YgeY D3868_22760 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D3868_22765 ENOG4108JQ6 ABC transporter D3868_22775 ENOG4105CE7 Amidase, hydantoinase carbamoylase family D3868_22790 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme D3868_22795 ENOG4108594 Permease of the drug metabolite transporter D3868_22800 ENOG4105ETE Transcriptional regulator (LacI family D3868_22805 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit D3868_22810 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_22820 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate D3868_22830 ENOG4105DS0 Transcriptional regulator, Crp Fnr family D3868_22835 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D3868_22845 ENOG4105K70 DNA-binding protein D3868_22860 ENOG4105HFZ Membrane D3868_22870 ENOG4105FCD Major Facilitator D3868_22905 ENOG4105K70 DNA-binding protein D3868_22915 ENOG4108UYB regulatoR D3868_22920 ENOG4105TX3 Histidine kinase D3868_22930 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) D3868_22935 ENOG4105CCU oxidase (Subunit III) D3868_22940 ENOG4105BZ9 Cytochrome C oxidase, subunit I D3868_22945 ENOG4105E2S oxidase) subunit II D3868_22950 ENOG4105CSH Transporter D3868_22960 ENOG4107Z4K Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) D3868_22965 ENOG4105CVJ phosphoglycerate mutase D3868_22975 ENOG4105BZU Histidine kinase D3868_22995 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) D3868_23045 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D3868_23065 ENOG4108T5G Adenylate D3868_23070 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D3868_23090 ENOG4105K56 Transcriptional regulator D3868_23095 ENOG4108ZHJ Organic hydroperoxide resistance protein D3868_23105 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D3868_23110 ENOG4105BZU Histidine kinase D3868_23120 ENOG4108HQS Glycine betaine D3868_23125 ENOG4108IJ7 Glycine betaine D3868_23130 ENOG4105DGW oligopeptidase A D3868_23135 ENOG41090B9 response to stress D3868_23160 ENOG4105EAB amino acid AbC transporter D3868_23165 ENOG4105E5Q amino acid AbC transporter D3868_23185 ENOG4105DB1 molybdopterin oxidoreductase D3868_23190 ENOG4106WHD Tetrathionate reductase D3868_23195 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D3868_23205 ENOG4105ETT transcriptional Regulator, LysR family D3868_23230 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) D3868_23235 ENOG4107QJE Chromosome Partitioning Protein D3868_23240 ENOG4105ERG peptidase m48, ste24p D3868_23260 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) D3868_23285 ENOG4105VFN O-Antigen polymerase D3868_23295 ENOG4107QQG Dehydrogenase D3868_23320 ENOG4108RYC glycosyltransferase D3868_23330 ENOG4105EW9 transcriptional regulator AsnC family D3868_23335 ENOG4105II7 pyrroline-5-carboxylate reductase D3868_23390 ENOG41080HT Transcriptional regulator, arsr family D3868_23395 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) D3868_23415 ENOG4107SA8 fad-dependent pyridine nucleotide-disulfide oxidoreductase D3868_23420 ENOG4106AFQ Histidine kinase D3868_23425 ENOG4108ZXC Two component transcriptional regulator, luxr family D3868_23440 ENOG4105CHR reductase D3868_23470 ENOG41062ES Transcriptional regulator D3868_23480 ENOG4108YXU transcriptional regulator AsnC family D3868_23495 ENOG4105HEI LysR family (Transcriptional regulator D3868_23500 ENOG4107XBN GntR Family Transcriptional Regulator D3868_23505 ENOG4108ERU trap dicarboxylate transporter subunit DctP D3868_23510 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_23515 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_23520 ENOG4105CKW Inner membrane protein yedI D3868_23540 ENOG4105EST Metal Dependent Phosphohydrolase D3868_23545 ENOG4105DA5 (ABC) transporter D3868_23550 ENOG4105E3A (ABC) transporter D3868_23555 ENOG4108Y50 Glutathione-dependent formaldehyde-activating Gfa D3868_23560 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D3868_23565 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D3868_23570 ENOG4108UAU isochorismatase D3868_23575 ENOG4105DEF Extracellular solute-binding protein, family 5 D3868_23580 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D3868_23585 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D3868_23595 ENOG4108JQ7 (ABC) transporter D3868_23600 ENOG4108UAU isochorismatase D3868_23605 ENOG4108KK1 membrane protein AbrB duplication D3868_23610 ENOG4105DRR Transcriptional regulator, GntR family D3868_23620 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) D3868_23625 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) D3868_23630 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) D3868_23635 ENOG4105C08 Histidine kinase D3868_23645 ENOG4108ZCF integral membrane protein D3868_23650 ENOG4105F8J Adenylate Guanylate cyclase D3868_23655 ENOG4105DS0 Transcriptional regulator, Crp Fnr family D3868_23660 ENOG4108YYC ycei family D3868_23680 ENOG4108ZXC Two component transcriptional regulator, luxr family D3868_23685 ENOG4108ZXC Two component transcriptional regulator, luxr family D3868_23690 ENOG4105BZU Histidine kinase D3868_23700 ENOG4105ENJ RND efflux system, outer membrane lipoprotein D3868_23705 ENOG4105BZS acriflavin resistance protein D3868_23710 ENOG4105BZS acriflavin resistance protein D3868_23715 ENOG4105ENT Efflux transporter rnd family, mfp subunit D3868_23720 ENOG4105CHM Aminotransferase D3868_23725 ENOG4105CYC Transferase D3868_23750 ENOG4105C3J Cysteine desulfurase D3868_23810 ENOG4106JUT Streptomycin 3''-adenylyltransferase D3868_23840 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D3868_23850 ENOG4105D0S secretion protein (HlyD D3868_23855 ENOG4105BZS acriflavin resistance protein D3868_23865 ENOG4105IPI Membrane D3868_23870 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) D3868_23910 ENOG4107QJE Chromosome Partitioning Protein D3868_23915 ENOG4107UX3 phosphatidylethanolamine N-methyltransferase D3868_23920 ENOG4107T3P ABC, transporter D3868_23935 ENOG4108IJ9 (ABC) transporter D3868_23940 ENOG4105E98 transcriptional regulator DeoR family D3868_23950 ENOG4108YYH Nadph-dependent fmn reductase D3868_23960 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor D3868_23960 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor D3868_23970 ENOG4108IV0 ABC, transporter D3868_23975 ENOG4105C0Z ABC transporter D3868_23980 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D3868_23985 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_24000 ENOG4105CJP fad dependent oxidoreductase D3868_24005 ENOG4105CH2 amidohydrolase D3868_24015 ENOG4105CEY Amp-dependent synthetase and ligase D3868_24050 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) D3868_24055 ENOG4105C8Q Methyl-accepting chemotaxis D3868_24080 ENOG4105CHR reductase D3868_24085 ENOG4105CG3 alpha amylase, catalytic region D3868_24090 ENOG410830R acetyltransferase D3868_24105 ENOG4105CQZ Histidine kinase D3868_24110 ENOG4105BZU Histidine kinase D3868_24115 ENOG4107ZHV Transcriptional regulator D3868_24135 ENOG4105C8Q Methyl-accepting chemotaxis D3868_24165 ENOG4105IBP Cyclic peptide transporter D3868_24170 ENOG4105IBP Cyclic peptide transporter D3868_24195 ENOG4107T5V SNARE associated Golgi D3868_24200 ENOG4105C6V Glycerol-3-phosphate dehydrogenase D3868_24205 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_24220 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component D3868_24235 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) D3868_24240 ENOG4105H9W Short-chain dehydrogenase reductase Sdr D3868_24265 ENOG41081FY multiple antibiotic resistance (MarC)-related D3868_24270 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D3868_24280 ENOG4105C8Q Methyl-accepting chemotaxis D3868_24285 ENOG4108V3W Chemotaxis protein, CheW D3868_24290 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D3868_24300 ENOG4105BZU Histidine kinase D3868_24305 ENOG4105BZU Histidine kinase D3868_24310 ENOG4105CBS Chea signal transduction histidine kinase D3868_24320 ENOG4108VB1 regulatoR D3868_24335 ENOG4105CWC Acetylornithine deacetylase D3868_24345 ENOG4108Q71 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) D3868_24370 ENOG4105CQZ Histidine kinase D3868_24395 ENOG4108I5D sulfate abc transporter D3868_24400 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_24415 ENOG4105CWC Acetylornithine deacetylase D3868_24420 ENOG4105CYW agmatinase D3868_24425 ENOG4105KME endoribonuclease L-psp D3868_24435 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D3868_24445 ENOG4105DEF Extracellular solute-binding protein, family 5 D3868_24455 ENOG4108M0I Transcriptional regulator D3868_24465 ENOG41080Z8 PHOSPHOCARRIER protein D3868_24470 ENOG4108EQA pts system D3868_24475 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) D3868_24480 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) D3868_24490 ENOG4105EB3 Histidine kinase D3868_24495 ENOG4105E3W Two component transcriptional regulator (Winged helix family D3868_24510 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) D3868_24515 ENOG4107RD7 Flagellar Motor Protein, MotA D3868_24525 ENOG4105DR5 peptidase D3868_24575 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) D3868_24605 ENOG4105CQ0 ABC transporter D3868_24640 ENOG4105NIV Esterase D3868_24655 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase D3868_24665 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase D3868_24675 ENOG4108IPT Naphthoate synthase D3868_24680 ENOG4107QX3 carboxylase D3868_24685 ENOG4105C1G acyl-Coa dehydrogenase D3868_24690 ENOG4105CHU acetyl-coa acetyltransferase D3868_24695 ENOG4105C1G acyl-Coa dehydrogenase D3868_24710 ENOG4108IV0 ABC, transporter D3868_24725 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_24735 ENOG4105C0Z ABC transporter D3868_24745 ENOG4105DEF Extracellular solute-binding protein, family 5 D3868_24750 ENOG4105BZU Histidine kinase D3868_24755 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D3868_24775 ENOG4105D05 Receptor D3868_24780 ENOG4105E8G Major facilitator Superfamily D3868_24790 ENOG4105BZS acriflavin resistance protein D3868_24800 ENOG4105E4F Isochorismate synthase D3868_24805 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase D3868_24810 ENOG4105WQI isochorismatase D3868_24815 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase D3868_24825 ENOG4105CEY Amp-dependent synthetase and ligase D3868_24830 ENOG4105E93 esterase D3868_24840 ENOG4105C1G acyl-Coa dehydrogenase D3868_24845 ENOG4107YCY Transcriptional regulator D3868_24850 ENOG4105CEY Amp-dependent synthetase and ligase D3868_24855 ENOG4108IG5 Transcriptional regulator D3868_24870 ENOG4105CMR udp-glucose 4-epimerase D3868_24875 ENOG4108JJ6 Type I secretion system ATPase D3868_24900 ENOG4105G47 Methyltransferase, type 11 D3868_24965 ENOG4108ZCF integral membrane protein D3868_24975 ENOG4105CJW magnesium transporter D3868_24980 ENOG4105DRR Transcriptional regulator, GntR family D3868_24985 ENOG4105C26 Dehydrogenase D3868_24990 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D3868_24995 ENOG4105EVZ LysR family transcriptional regulator D3868_25020 ENOG4105CAQ asparagine synthetase D3868_25025 ENOG4105D9M gamma-glutamylcysteine synthetase D3868_25030 ENOG4105DER m42 family D3868_25045 ENOG4108NEV two component transcriptional regulator, LytTR family D3868_25050 ENOG4108HRK Histidine kinase D3868_25060 ENOG4105K6T rare lipoprotein A D3868_25090 ENOG4108ZZF transport protein (ExbD) D3868_25095 ENOG4105YHG TonB family D3868_25100 ENOG4108ZXC Two component transcriptional regulator, luxr family D3868_25105 ENOG4105BZU Histidine kinase D3868_25125 ENOG4108NVR Methyl-accepting chemotaxis D3868_25145 ENOG4107R0W ABC transporter D3868_25150 ENOG4105E89 ABC transporter D3868_25155 ENOG4105BZU Histidine kinase D3868_25160 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D3868_25165 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D3868_25180 ENOG4105CHR reductase D3868_25200 ENOG4105JN3 extra-cytoplasmic solute receptor family protein D3868_25205 ENOG4108RTU Aldolase D3868_25210 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 D3868_25215 ENOG4107HP6 Transcriptional regulator D3868_25220 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D3868_25225 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) D3868_25235 ENOG41073TP transcriptional regulator D3868_25240 ENOG4105DAA L-lactate D3868_25245 ENOG4105CQB FAD linked oxidase domain protein D3868_25250 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D3868_25255 ENOG4107QR9 Iron-sulfur cluster binding protein D3868_25260 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) D3868_25295 ENOG4105D8X mechanosensitive ion channel D3868_25400 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D3868_25425 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) D3868_25435 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein D3868_25440 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) D3868_25455 ENOG4107R9N ABC transporter D3868_25460 ENOG4105C0Z ABC transporter D3868_25465 ENOG4108IV0 ABC, transporter D3868_25475 ENOG4105CHR reductase D3868_25490 ENOG4108RXX maleylacetoacetate isomerase D3868_25505 ENOG4107Y5K Resolvase D3868_25570 ENOG4105E5H Transposase D3868_25575 ENOG4108YXQ IS66 Orf2 family protein D3868_25610 ENOG4105MP0 transposase D3868_25615 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family D3868_25620 ENOG4105E39 Enoyl-CoA hydratase D3868_25625 ENOG4105CEY Amp-dependent synthetase and ligase D3868_25635 ENOG4105F38 ABC transporter, permease D3868_25645 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_25675 ENOG4105D6J arsenicaL-resistance protein D3868_25680 ENOG4105CAU Arsenical resistance protein, ArsH D3868_25710 ENOG4105E0A ABC, transporter D3868_25720 ENOG4105S6R Iron-hydroxamate transporter permease subunit D3868_25730 ENOG4105E0K tonB-dependent siderophore receptor D3868_25735 ENOG4105IBP Cyclic peptide transporter D3868_25745 ENOG4105E0K tonB-dependent siderophore receptor D3868_25750 ENOG4108SF5 RNA Polymerase D3868_25760 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_25780 ENOG4107RCH Diaminopropionate ammonia-lyase D3868_25785 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D3868_25795 ENOG4105KME endoribonuclease L-psp D3868_25830 ENOG4105E1F short-chain dehydrogenase reductase D3868_25850 ENOG4105CY2 Citrate transporter D3868_25880 ENOG4105RAK Histidine kinase D3868_25890 ENOG4105D1N poly(r)-hydroxyalkanoic acid synthase, class D3868_25910 ENOG4105CEY Amp-dependent synthetase and ligase D3868_25915 ENOG4105C5T Phosphoribosyl pyrophosphate synthase D3868_25930 ENOG4105VN1 Heat shock protein D3868_25940 ENOG4105CAR Terminase, large subunit D3868_25980 ENOG4105CDA abc transporter atp-binding protein D3868_26040 ENOG4105UHE Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) D3868_26060 ENOG4107WCG it plays a direct role in the translocation of protons across the membrane (By similarity) D3868_26070 ENOG4108Q71 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) D3868_26075 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) D3868_26080 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) D3868_26090 ENOG4105Y49 secretion protein, HlyD family D3868_26105 ENOG4105R1U AraC Family Transcriptional Regulator D3868_26120 ENOG4108HW3 (ABC) transporter D3868_26130 ENOG4105E5Q amino acid AbC transporter D3868_26135 ENOG4105CDA abc transporter atp-binding protein D3868_26140 ENOG4105C26 Dehydrogenase D3868_26150 ENOG4105E2X shikimate dehydrogenase D3868_26160 ENOG4105CTX dehydratase D3868_26170 ENOG4105JN3 extra-cytoplasmic solute receptor family protein D3868_26185 ENOG4105DG4 malate L-lactate dehydrogenase D3868_26190 ENOG4105CEI nitrite reductase D3868_26200 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase D3868_26205 ENOG4107258 Transcriptional regulator D3868_26215 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D3868_26220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D3868_26245 ENOG4107FQ9 ethanolamine ammonia-lyase D3868_26250 ENOG4105CPD ethanolamine ammonia-lyase D3868_26255 ENOG4105MWK D-amino acid dehydrogenase, small subunit D3868_26265 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_26275 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D3868_26280 ENOG4107SQD Transcriptional regulator, GntR family D3868_26290 ENOG4105RQ9 TPR repeat-containing protein D3868_26310 ENOG4105DTS flagellar hook-associated D3868_26315 ENOG4105I03 Flagellin D3868_26340 ENOG4105BZE flagellar hook protein, FlgE D3868_26345 ENOG4105W00 Flagellar hook capping protein D3868_26360 ENOG4105CPC Aldo Keto reductase D3868_26380 ENOG4105CHB tonB-dependent Receptor D3868_26410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D3868_26415 ENOG4105XJC Two component transcriptional regulator (Winged helix family D3868_26430 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit D3868_26435 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding D3868_26440 ENOG4105C7W Xanthine dehydrogenase D3868_26465 ENOG410642W LysR family Transcriptional regulator D3868_26510 ENOG4105E39 Enoyl-CoA hydratase D3868_26515 ENOG4105CPP Dehydrogenase, E1 component D3868_26520 ENOG4107RUY (E1 component), alpha subunit D3868_26530 ENOG41083Z3 extracellular ligand-binding receptor D3868_26535 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_26540 ENOG4105C0Z ABC transporter D3868_26545 ENOG4108IV0 ABC, transporter D3868_26555 ENOG4105ECQ AraC Family Transcriptional Regulator D3868_26560 ENOG4105EMU Dehydrogenase D3868_26565 ENOG4108RWP Major Facilitator Superfamily protein D3868_26580 ENOG4105E0K tonB-dependent siderophore receptor D3868_26595 ENOG4105DRR Transcriptional regulator, GntR family D3868_26600 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_26605 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter D3868_26610 ENOG4105CXK mandelate racemase muconate lactonizing D3868_26615 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D3868_26625 ENOG4107Z5M This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) D3868_26630 ENOG4108R9S DSBA oxidoreductase D3868_26635 ENOG4105PGM cation diffusion facilitator family transporter D3868_26645 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) D3868_26650 ENOG4105F38 ABC transporter, permease D3868_26655 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_26665 ENOG4105CQB FAD linked oxidase domain protein D3868_26675 ENOG4105CMI transporter D3868_26680 ENOG4105CJ1 ABC, transporter D3868_26685 ENOG4105D0S secretion protein (HlyD D3868_26690 ENOG4105E2R ROK family D3868_26700 ENOG4105CNN ABC, transporter D3868_26705 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator D3868_26720 ENOG4105C93 Xylose Isomerase D3868_26725 ENOG4105CMG Carbohydrate kinase D3868_26730 ENOG4105CC0 LysR family Transcriptional regulator D3868_26740 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D3868_26750 ENOG4108WYP Transcriptional regulator D3868_26760 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D3868_26770 ENOG4105KVH Transcriptional regulator D3868_26780 ENOG4105DZG Dehydrogenase D3868_26785 ENOG4105BZU Histidine kinase D3868_26790 ENOG4105WH1 Two component transcriptional regulator luxr family D3868_26800 ENOG4107RUE extracellular solute-binding protein family 1 D3868_26805 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_26810 ENOG4105F38 ABC transporter, permease D3868_26815 ENOG4105D81 ABC transporter, permease D3868_26820 ENOG4105CTU Proline racemase D3868_26825 ENOG4105DRR Transcriptional regulator, GntR family D3868_26830 ENOG4105CR4 methylisocitrate lyase D3868_26835 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D3868_26840 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) D3868_26855 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component D3868_26860 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D3868_26870 ENOG4107QPV Serine Threonine protein kinase D3868_26895 ENOG4107FQ9 ethanolamine ammonia-lyase D3868_26900 ENOG4105CPD ethanolamine ammonia-lyase D3868_26975 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein D3868_26990 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3868_27015 ENOG4105CKI cobalamin synthesis protein D3868_27055 ENOG4105CHR reductase D3868_27110 ENOG41061TZ Short-chain dehydrogenase reductase Sdr D3868_27135 ENOG4105E39 Enoyl-CoA hydratase D3868_27140 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D3868_27145 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D3868_27165 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D3868_27185 ENOG4105EMN RNA polymerase sigma factor D3868_27200 ENOG4105T38 integral membrane protein D3868_27215 ENOG4105FDP GntR family transcriptional regulator D3868_27245 ENOG4105FDK ABC transporter D3868_27260 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D3868_27275 ENOG4108S3W Anti-feci sigma factor, fecr D3868_27280 ENOG4108SF5 RNA Polymerase D3868_27305 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family D3868_27365 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) D3868_27410 ENOG4108ZHJ Organic hydroperoxide resistance protein D3868_27415 ENOG4105K56 Transcriptional regulator D3868_27420 ENOG4105ETT transcriptional Regulator, LysR family D3868_27425 ENOG4105CHR reductase D3868_27460 ENOG4105C7F AcnD-accessory protein PrpF D3868_27465 ENOG4108I0Z Aconitate hydratase D3868_27470 ENOG4105BZN citrate synthase D3868_27480 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D3868_27490 ENOG4105CFF transcriptional regulator D3868_27500 ENOG4105DZ2 Transcriptional regulator D3868_27535 ENOG4108N0N Phage Terminase Large Subunit D3868_27560 ENOG4105CNT hydrolase family 2 D3868_27565 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D3868_27575 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_27590 ENOG4108ZCF integral membrane protein D3868_27595 ENOG4105M4H endoribonuclease L-psp D3868_27605 ENOG4105M4H endoribonuclease L-psp D3868_27610 ENOG4105MWK D-amino acid dehydrogenase, small subunit D3868_27630 ENOG4105D38 putrescine abc transporter D3868_27635 ENOG4105F38 ABC transporter, permease D3868_27640 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_27655 ENOG4105DMF Dehydrogenase D3868_27660 ENOG4108JCI Transcriptional regulator D3868_27675 ENOG4105DE9 3-keto-5-aminohexanoate cleavage enzyme D3868_27680 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) D3868_27685 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D3868_27700 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) D3868_27705 ENOG4105K5G 30S ribosomal protein S21 D3868_27720 ENOG4106322 response regulator D3868_27730 ENOG4108IV0 ABC, transporter D3868_27735 ENOG4105C0Z ABC transporter D3868_27750 ENOG4105CAD extracellular ligand-binding receptor D3868_27755 ENOG4105D2S major facilitator superfamily D3868_27865 ENOG4105KUS lysozyme D3868_28285 ENOG4105JSC dimethylmenaquinone methyltransferase D3868_28295 ENOG4105GAK amidohydrolase 2 D3868_28315 ENOG4107Z7P Ferredoxin D3868_28320 ENOG4106A3M Cytochrome p-450 D3868_28335 ENOG4107F9Y LysR family transcriptional regulator D3868_28360 ENOG4105CHU acetyl-coa acetyltransferase D3868_28365 ENOG4105DCM major facilitator superfamily D3868_28370 ENOG4105CBN LysR family transcriptional regulator D3868_28400 ENOG4108W3Y Transcriptional regulator, Crp Fnr family D3868_28415 ENOG4105CFP Peptidase U32 D3868_28440 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D3868_28455 ENOG4108T0W nitrous oxide maturation protein NosY D3868_28460 ENOG4105CIG ABC transporter D3868_28475 ENOG4105EQJ Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) D3868_28480 ENOG4105HEE Binding Domain protein D3868_28495 ENOG4105GMT ATPase associated with various cellular activities aaa_5 D3868_28530 ENOG4105DQQ Major facilitator superfamily MFS_1 D3868_28580 ENOG4105D1F ATP-binding protein D3868_28635 ENOG4105C1J atp-dependent rna helicase D3868_28660 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_28685 ENOG4105CEY Amp-dependent synthetase and ligase D3868_28705 ENOG4105C26 Dehydrogenase D3868_28715 ENOG4107YCY Transcriptional regulator D3868_28755 ENOG4108YXQ IS66 Orf2 family protein D3868_28780 ENOG4105CHR reductase D3868_28800 ENOG4108R6W Transcriptional regulator, ARAC family D3868_28835 ENOG4105CHR reductase D3868_28850 ENOG4105CHR reductase D3868_28865 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component D3868_28880 ENOG4107EFR Flavocytochrome c D3868_28885 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D3868_28890 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) D3868_28910 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) D3868_28920 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein D3868_29020 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) D3868_29030 ENOG4105DD5 Flagellar motor switch protein D3868_29035 ENOG4105CN7 Flagellar biosynthetic protein FliP D3868_29045 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D3868_29065 ENOG4105D8X mechanosensitive ion channel D3868_29085 ENOG4105C26 Dehydrogenase D3868_29270 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D3868_29280 ENOG4105DG4 malate L-lactate dehydrogenase D3868_29290 ENOG410620I Diguanylate cyclase D3868_29305 ENOG4105BZ1 (ABC) transporter D3868_29355 ENOG4105ETT transcriptional Regulator, LysR family D3868_29360 ENOG4105JXB ankyrin repeat-containing protein D3868_29375 ENOG4105EMN RNA polymerase sigma factor D3868_29395 ENOG41085JF Trap dicarboxylate transporter-dctp subunit D3868_29415 ENOG4108PGP mmge prpd family protein D3868_29420 ENOG4105C1G acyl-Coa dehydrogenase D3868_29425 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D3868_29440 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D3868_29450 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_29455 ENOG4105FDP GntR family transcriptional regulator D3868_29495 ENOG41062D9 Histidine kinase D3868_29510 ENOG4108ZCF integral membrane protein D3868_29545 ENOG4105CTX dehydratase D3868_29550 ENOG4105D2H Uronic isomerase D3868_29555 ENOG4108Z5K methylglyoxal synthase D3868_29560 ENOG4107XBN GntR Family Transcriptional Regulator D3868_29565 ENOG4105CPC Aldo Keto reductase D3868_29570 ENOG4108ESX Receptor D3868_29590 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_29600 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D3868_29605 ENOG4105M5J Cupin 2, conserved barrel domain protein D3868_29610 ENOG4105CHR reductase D3868_29615 ENOG4107XBN GntR Family Transcriptional Regulator D3868_29630 ENOG4105DEI Mannitol dehydrogenase D3868_29635 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) D3868_29675 ENOG4105D8V Glucose sorbosone dehydrogenase D3868_29690 ENOG4105C5Q Transcriptional regulator D3868_29700 ENOG4105KVH Transcriptional regulator D3868_29705 ENOG4105ECR NmrA family D3868_29710 ENOG4105BZS acriflavin resistance protein D3868_29715 ENOG4105ENT Efflux transporter rnd family, mfp subunit D3868_29720 ENOG4105MKU Transcriptional regulator D3868_29730 ENOG4105E3B Multicopper oxidase D3868_29735 ENOG4108ZPC Polysaccharide pyruvyl transferase D3868_29750 ENOG4107XNE ABC transporter, periplasmic molybdate-binding protein D3868_29755 ENOG4107QZW Altronate oxidoreductase D3868_29760 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) D3868_29780 ENOG4108HWW ABC transporter D3868_29820 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator D3868_29825 ENOG4105C2J ABC transporter D3868_29830 ENOG4107R9N ABC transporter D3868_29835 ENOG41062B0 ABC transporter, permease D3868_29840 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) D3868_29845 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) D3868_29850 ENOG4105C5T Phosphoribosyl pyrophosphate synthase D3868_29860 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase D3868_29880 ENOG4105CEY Amp-dependent synthetase and ligase D3868_29885 ENOG4105VEQ Cold shock protein D3868_29890 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) D3868_29900 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) D3868_29910 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) D3868_29915 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D3868_29920 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) D3868_29930 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D3868_29955 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) D3868_29990 ENOG4105DIH basic membrane D3868_30000 ENOG4105CAN Short-chain dehydrogenase reductase Sdr D3868_30010 ENOG4105CWC Acetylornithine deacetylase D3868_30015 ENOG4108JQ7 (ABC) transporter D3868_30020 ENOG4105C3U ABC transporter D3868_30030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D3868_30035 ENOG4105DEF Extracellular solute-binding protein, family 5 D3868_30050 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) D3868_30065 ENOG4105CJW magnesium transporter D3868_30080 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) D3868_30135 ENOG4107SQD Transcriptional regulator, GntR family D3868_30140 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) D3868_30150 ENOG4105D2N Aldolase D3868_30175 ENOG4105BZU Histidine kinase D3868_30190 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) D3868_30195 ENOG4105DE4 1-phosphofructokinase D3868_30200 ENOG4105DM4 PTS System D3868_30215 ENOG4108JQC penicillin-binding protein 1A D3868_30220 ENOG4105D7W serine acetyltransferase D3868_30235 ENOG4105EVZ LysR family transcriptional regulator D3868_30245 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D3868_30250 ENOG4105F38 ABC transporter, permease D3868_30255 ENOG4107RCV ABC transporter, permease D3868_30270 ENOG4105C7B Threonine dehydratase D3868_30275 ENOG4105C2W permease D3868_30280 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) D3868_30295 ENOG4105BZ9 Cytochrome C oxidase, subunit I D3868_30300 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) D3868_30305 ENOG4106RE7 Cytochrome D3868_30315 ENOG4105BZU Histidine kinase D3868_30325 ENOG4105DA5 (ABC) transporter D3868_30350 ENOG4105C2M dna polymerase I D3868_30370 ENOG4105C3G gtp-binding protein D3868_30375 ENOG4105BZU Histidine kinase D3868_30385 ENOG410811B TRANSCRIPTIONal D3868_30390 ENOG4105CZM Major Facilitator D3868_30400 ENOG4105CHR reductase D3868_30405 ENOG4105CHU acetyl-coa acetyltransferase D3868_30410 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) D3868_30505 ENOG4106R7G Glycoside hydrolase family 5 D3868_30530 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) D3868_30540 ENOG4108JQ9 ABC transporter D3868_30545 ENOG41083U2 ABC transporter, permease D3868_30555 ENOG4105DZC cytosine deaminase D3868_30565 ENOG4105BZU Histidine kinase D3868_30585 ENOG4108Z4X TRANSCRIPTIONal D3868_30595 ENOG41069M3 Transcriptional regulator D3868_30600 ENOG4108IEG Formate dehydrogenase Alpha subunit D3868_30610 ENOG4105CFN oxalyl-CoA decarboxylase D3868_30620 ENOG4107TE5 Lipid kinase D3868_30625 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D3868_30630 ENOG4105DSF transport protein D3868_30635 ENOG4105G4C Periplasmic ligand-binding sensor protein D3868_30670 ENOG4105EFQ Two component transcriptional regulator (Winged helix family D3868_30680 ENOG4107XBN GntR Family Transcriptional Regulator D3868_30685 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) D3868_30690 ENOG4105CHR reductase D3868_30700 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D3868_30710 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) D3868_30715 ENOG4105C6N Formate acetyltransferase D3868_30720 ENOG4105CHC glucokinase (EC 2.7.1.2) D3868_30725 ENOG4105BZS acriflavin resistance protein D3868_30730 ENOG4105C1P efflux transporter, rnd family, mfp subunit D3868_30735 ENOG4108IND Tetr family transcriptional regulator D3868_30740 ENOG4105YA8 Transcriptional regulator D3868_30745 ENOG4105BZU Histidine kinase D3868_30750 ENOG4105BZU Histidine kinase D3868_30760 ENOG4105CA9 Pyruvate kinase D3868_30765 ENOG4105F1A Pyruvate formate-lyase D3868_30770 ENOG4105TMB Formate nitrite transporter D3868_30775 ENOG4108SXK Transporter Drug Metabolite Exporter family D3868_30780 ENOG4107XBN GntR Family Transcriptional Regulator D3868_30785 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D3868_30795 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_30800 ENOG4108ZCF integral membrane protein D3868_30830 ENOG4105BZE flagellar hook protein, FlgE D3868_30835 ENOG4105E1Q flagellar hook-associated protein D3868_30845 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) D3868_30865 ENOG4105XYF acetyltransferase D3868_30870 ENOG4105BZU Histidine kinase D3868_30875 ENOG4105EQ2 LysR family Transcriptional regulator D3868_30895 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr D3868_30905 ENOG4105CN1 protease D3868_30910 ENOG4107FSV UPF0391 membrane protein D3868_30920 ENOG4105BZU Histidine kinase D3868_30950 ENOG4105D00 flagellar biosynthetic protein flhB D3868_30955 ENOG4105D19 Role in flagellar biosynthesis (By similarity) D3868_30960 ENOG4105D7B Flagellar biosynthesis protein flha D3868_30975 ENOG4105X50 flagellar hook-basal body complex protein fliE D3868_30980 ENOG4108ZC9 flagellar basal-body rod protein flgc D3868_30985 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) D3868_30990 ENOG4108JIR Flagellum-specific ATP synthase D3868_31000 ENOG4105JQN Transcriptional regulator D3868_31005 ENOG4105EQ0 Major Facilitator superfamily D3868_31025 ENOG4105IE4 repressor protein FlbT D3868_31035 ENOG4107W75 Flagellin D3868_31040 ENOG4105EFQ Two component transcriptional regulator (Winged helix family D3868_31060 ENOG4107SS6 2-dehydro-3-deoxygluconokinase D3868_31065 ENOG4107XBN GntR Family Transcriptional Regulator D3868_31070 ENOG4108UHU Aldolase D3868_31080 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) D3868_31085 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) D3868_31090 ENOG4105E0A ABC, transporter D3868_31095 ENOG4105EHG Permease protein D3868_31100 ENOG4105S10 periplasmic binding protein D3868_31115 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR D3868_31130 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F D3868_31145 ENOG4105C1G acyl-Coa dehydrogenase D3868_31150 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 D3868_31155 ENOG4105CH5 extracellular solute-binding protein, family 7 D3868_31165 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D3868_31170 ENOG41084M5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) D3868_31185 ENOG4105CQB FAD linked oxidase domain protein D3868_31190 ENOG4105BZJ Electron transfer flavoprotein D3868_31195 ENOG4105C10 Electron transfer flavoprotein D3868_31215 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) D3868_31235 ENOG4108IV0 ABC, transporter D3868_31240 ENOG4105C0Z ABC transporter D3868_31250 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_31265 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D3868_31275 ENOG4105CD3 dihydroorotase D3868_31295 ENOG4105CP9 extracellular ligand-binding receptor D3868_31300 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_31305 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D3868_31310 ENOG4105C0Z ABC transporter D3868_31315 ENOG4108IV0 ABC, transporter D3868_31325 ENOG4105RE0 Asp Glu hydantoin racemase D3868_31340 ENOG4108UAU isochorismatase D3868_31350 ENOG4108M60 Transcriptional regulator D3868_31355 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) D3868_31360 ENOG4105DE4 1-phosphofructokinase D3868_31365 ENOG4105DM4 PTS System D3868_31375 ENOG4105RAK Histidine kinase D3868_31380 ENOG4105WH1 Two component transcriptional regulator luxr family D3868_31410 ENOG410642W LysR family Transcriptional regulator D3868_31415 ENOG4107S1E Beta-lactamase D3868_31425 ENOG4105CJP fad dependent oxidoreductase D3868_31430 ENOG4105CH2 amidohydrolase D3868_31440 ENOG4108IV0 ABC, transporter D3868_31445 ENOG4105C0Z ABC transporter D3868_31450 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D3868_31455 ENOG4105C32 Amino acid ABC transporter (Permease) D3868_31480 ENOG4108XM1 transcriptional regulator AsnC family D3868_31490 ENOG4108FUF Transcriptional regulator, IclR family D3868_31495 ENOG4107QYA phosphate D3868_31515 ENOG4108EKI Dehydrogenase D3868_31520 ENOG4105CMV Succinyl-CoA synthetase subunit beta D3868_31525 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha D3868_31530 ENOG4105DB1 molybdopterin oxidoreductase D3868_31535 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D3868_31555 ENOG4105FA0 parb-like partition protein D3868_31560 ENOG4107QJE Chromosome Partitioning Protein D3868_31580 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 D3868_31595 ENOG4105HMI Membrane D3868_31600 ENOG4105DUM transcriptional regulator, lysR family D3868_31665 ENOG4105C26 Dehydrogenase D3868_31670 ENOG4105C7K acetolactate synthase D3868_31675 ENOG4105ETT transcriptional Regulator, LysR family D3868_31680 ENOG4105C0D helicase D3868_31685 ENOG4105BZS acriflavin resistance protein D3868_31700 ENOG4105EMU Dehydrogenase D3868_31730 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D3868_31785 ENOG4108EKI Dehydrogenase D3868_31790 ENOG4108JUA Transcriptional regulator D3868_31855 ENOG4105F9N Major Facilitator Superfamily D3868_31860 ENOG4105ER2 Ompa motb domain protein D3868_31865 ENOG4107RD7 Flagellar Motor Protein, MotA D3868_31875 ENOG4105KTQ flagellar basal-body rod protein D3868_31880 ENOG4105CGA flagellar basal-body rod protein FlgG D3868_31885 ENOG4105XZC flagellar basal body P-ring biosynthesis protein FlgA D3868_31890 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) D3868_31910 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) D3868_31975 ENOG4105DD5 Flagellar motor switch protein D3868_32020 ENOG4105EY8 ABC transporter D3868_32055 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) D3868_32060 ENOG4105K64 Glycosyl transferase, family 2 D3868_32070 ENOG4105CKK Glycosyl transferase, family 2 D3868_32110 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) D3868_32125 ENOG4105E2K Glycosyl transferase (Group 1 D3868_32145 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D3868_32155 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) D3868_32175 ENOG4105C1B dTDP-glucose 4-6-dehydratase D3868_32200 ENOG4105EWA aspartate glutamate uridylate kinase D3868_32205 ENOG4107YCI aspartate glutamate uridylate kinase D3868_32225 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) D3868_32240 ENOG4105JSC dimethylmenaquinone methyltransferase D3868_32250 ENOG4105C5E polysaccharide biosynthesis protein D3868_32265 ENOG4105C6Y Udp-glucose 6-dehydrogenase D3868_32275 ENOG4105FA0 parb-like partition protein D3868_32280 ENOG4107QJE Chromosome Partitioning Protein D3868_32305 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase D3868_32315 ENOG4108IAJ Nad-dependent epimerase dehydratase D3868_32360 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) D3868_32365 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) D3868_32425 ENOG4105CTC Lipopolysaccharide biosynthesis protein-like protein D3868_32435 ENOG4105C0K Gdp-mannose 4,6-dehydratase D3868_32460 ENOG4108JJA ABC, transporter D3868_32465 ENOG4105C42 Type I secretion membrane fusion protein (HlyD D3868_32485 ENOG4105C1B dTDP-glucose 4-6-dehydratase D3868_32495 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) D3868_32500 ENOG4105QNJ serralysin (EC 3.4.24.40) D3868_32505 ENOG4105D5U fad dependent oxidoreductase D3868_32510 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) D3868_32520 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) D3868_32555 ENOG4105EY8 ABC transporter