locus-tag	class	description
D3868_00055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3868_00060	COG1129	ABC transporter
D3868_00100	COG3706	GGDEF domain
D3868_00100	COG0745	RESPONSE REGULATOR receiver
D3868_00105	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3868_00110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3868_00125	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_00130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3868_00135	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D3868_00145	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D3868_00150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3868_00155	COG0351	phosphomethylpyrimidine kinase
D3868_00160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3868_00175	COG0670	Belongs to the BI1 family
D3868_00180	COG4325	translation initiation factor activity
D3868_00200	COG2030	dehydratase
D3868_00200	COG1012	belongs to the aldehyde dehydrogenase family
D3868_00205	COG0443	Heat shock 70 kDa protein
D3868_00230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3868_00230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D3868_00280	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3868_00285	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3868_00295	COG0649	NAD binding
D3868_00300	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D3868_00310	COG1034	ATP synthesis coupled electron transport
D3868_00315	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D3868_00320	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3868_00330	COG0713	ATP synthesis coupled electron transport
D3868_00345	COG1007	ATP synthesis coupled electron transport
D3868_00375	COG0519	Catalyzes the synthesis of GMP from XMP
D3868_00390	COG0442	prolyl-tRNA aminoacylation
D3868_00420	COG0587	DNA-directed DNA polymerase activity
D3868_00425	COG0052	Belongs to the universal ribosomal protein uS2 family
D3868_00430	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D3868_00435	COG0528	UMP kinase activity
D3868_00440	COG0233	cytoplasmic translational termination
D3868_00445	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3868_00450	COG0575	Belongs to the CDS family
D3868_00455	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D3868_00460	COG0750	zinc metalloprotease
D3868_00480	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3868_00485	COG3494	Protein of unknown function (DUF1009)
D3868_00490	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3868_00505	COG0583	DNA-binding transcription factor activity
D3868_00520	COG0372	Belongs to the citrate synthase family
D3868_00525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3868_00530	COG2333	competence protein COMEC
D3868_00530	COG0658	competence protein
D3868_00535	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3868_00540	COG0303	'Molybdopterin
D3868_00545	COG0315	cyclic pyranopterin monophosphate synthase activity
D3868_00590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3868_00600	COG0149	triose-phosphate isomerase activity
D3868_00630	COG0535	radical SAM domain protein
D3868_00635	COG0535	radical SAM domain protein
D3868_00640	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
D3868_00645	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D3868_00655	COG0148	phosphopyruvate hydratase activity
D3868_00665	COG0037	tRNA processing
D3868_00700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_00720	COG0596	Alpha beta hydrolase
D3868_00725	COG0728	peptidoglycan biosynthetic process
D3868_00735	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3868_00750	COG0436	Aminotransferase
D3868_00770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_00775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3868_00805	COG0840	transmembrane signaling receptor activity
D3868_00835	COG2205	protein histidine kinase activity
D3868_00840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D3868_00870	COG1024	Enoyl-CoA hydratase
D3868_00880	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D3868_00885	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D3868_00890	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D3868_00895	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D3868_00900	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3868_00900	COG2885	chlorophyll binding
D3868_00905	COG3243	poly(R)-hydroxyalkanoic acid synthase
D3868_00930	COG0436	Aminotransferase
D3868_00940	COG1494	fructose-1,6-bisphosphatase
D3868_00945	COG0371	Dehydrogenase
D3868_00950	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D3868_00950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D3868_01015	COG0656	L-ascorbic acid biosynthetic process
D3868_01040	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3868_01045	COG0517	IMP dehydrogenase activity
D3868_01050	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3868_01055	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3868_01060	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D3868_01080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3868_01085	COG0045	succinate-CoA ligase (ADP-forming) activity
D3868_01095	COG2814	Major facilitator Superfamily
D3868_01110	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D3868_01125	COG2084	Dehydrogenase
D3868_01130	COG3622	Belongs to the hyi family
D3868_01135	COG3960	tartronate-semialdehyde synthase activity
D3868_01140	COG0352	thiamine-phosphate diphosphorylase activity
D3868_01140	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D3868_01145	COG1802	Transcriptional regulator
D3868_01150	COG0469	pyruvate kinase activity
D3868_01160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3868_01160	COG0574	Belongs to the PEP-utilizing enzyme family
D3868_01185	COG3283	Transcriptional regulator of aromatic amino acids metabolism
D3868_01190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_01200	COG0693	protein deglycase activity
D3868_01205	COG2197	response regulator
D3868_01210	COG2197	response regulator
D3868_01225	COG0829	nickel cation binding
D3868_01230	COG0831	urea catabolic process
D3868_01235	COG0832	Belongs to the urease beta subunit family
D3868_01240	COG0804	urea catabolic process
D3868_01245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D3868_01250	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D3868_01255	COG0830	nickel cation binding
D3868_01260	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D3868_01265	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
D3868_01275	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3868_01290	COG0640	Transcriptional regulator
D3868_01320	COG1396	sequence-specific DNA binding
D3868_01345	COG1846	Transcriptional regulator
D3868_01355	COG0704	Plays a role in the regulation of phosphate uptake
D3868_01375	COG0463	Glycosyl transferase, family 2
D3868_01395	COG1940	carbohydrate kinase activity
D3868_01420	COG0410	ABC transporter
D3868_01445	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3868_01445	COG2885	chlorophyll binding
D3868_01450	COG2197	response regulator
D3868_01455	COG2198	Histidine kinase
D3868_01455	COG0784	Response regulator, receiver
D3868_01455	COG2205	protein histidine kinase activity
D3868_01470	COG0564	pseudouridine synthase activity
D3868_01475	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_01480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D3868_01495	COG0024	Methionine aminopeptidase
D3868_01510	COG1127	ABC transporter
D3868_01515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3868_01520	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3868_01525	COG0305	Participates in initiation and elongation during chromosome replication
D3868_01530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3868_01535	COG0359	binds to the 23S rRNA
D3868_01545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D3868_01550	COG0360	Binds together with S18 to 16S ribosomal RNA
D3868_01555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D3868_01570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3868_01575	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D3868_01585	COG0741	lytic transglycosylase activity
D3868_01590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3868_01595	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D3868_01600	COG2813	Specifically methylates the guanine in position
D3868_01610	COG1881	PFAM PEBP family protein
D3868_01615	COG0113	porphobilinogen synthase activity
D3868_01620	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3868_01625	COG1597	lipid kinase activity
D3868_01630	COG1024	Enoyl-CoA hydratase
D3868_01635	COG1846	Transcriptional regulator
D3868_01655	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_01670	COG0686	Belongs to the AlaDH PNT family
D3868_01680	COG0737	Belongs to the 5'-nucleotidase family
D3868_01685	COG0512	Glutamine amidotransferase of anthranilate synthase
D3868_01690	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3868_01695	COG3608	succinylglutamate desuccinylase aspartoacylase
D3868_01695	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D3868_01760	COG0123	including yeast histone deacetylase and acetoin utilization protein
D3868_01805	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D3868_01810	COG0626	cystathionine gamma-synthase activity
D3868_01815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_01820	COG4597	amino acid ABC transporter
D3868_01825	COG0765	amino acid transport
D3868_01830	COG1126	abc transporter atp-binding protein
D3868_01835	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3868_01855	COG2897	thiosulfate sulfurtransferase activity
D3868_01870	COG0494	nUDIX hydrolase
D3868_01875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3868_01900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3868_01910	COG1538	Outer membrane efflux protein
D3868_01920	COG0525	valine-tRNA ligase activity
D3868_01925	COG0840	transmembrane signaling receptor activity
D3868_01940	COG1686	Belongs to the peptidase S11 family
D3868_01945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D3868_01950	COG0470	DNA polymerase III
D3868_01955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3868_01960	COG0084	hydrolase, TatD family'
D3868_01965	COG0321	lipoyl(octanoyl) transferase activity
D3868_01965	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D3868_01980	COG0631	protein serine/threonine phosphatase activity
D3868_01990	COG2957	Belongs to the agmatine deiminase family
D3868_01995	COG1177	transmembrane transport
D3868_02000	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_02005	COG3842	ATPase activity
D3868_02015	COG0174	glutamine synthetase
D3868_02020	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_02050	COG0861	Integral membrane protein TerC family
D3868_02060	COG4957	zinc ion binding
D3868_02070	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3868_02095	COG1280	lysine exporter protein (LysE YggA)
D3868_02105	COG0314	molybdopterin synthase activity
D3868_02110	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D3868_02120	COG1763	Mo-molybdopterin cofactor biosynthetic process
D3868_02125	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3868_02135	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_02180	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D3868_02180	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D3868_02185	COG1160	GTP binding
D3868_02215	COG2197	response regulator
D3868_02255	COG0745	RESPONSE REGULATOR receiver
D3868_02255	COG3706	GGDEF domain
D3868_02285	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D3868_02290	COG2814	Major facilitator Superfamily
D3868_02305	COG0789	Transcriptional regulator
D3868_02310	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_02340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3868_02340	COG1116	anion transmembrane transporter activity
D3868_02350	COG0175	sulfate reduction
D3868_02355	COG0175	sulfate reduction
D3868_02360	COG1648	precorrin-2 dehydrogenase activity
D3868_02360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3868_02375	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3868_02390	COG4651	solute:proton antiporter activity
D3868_02390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3868_02415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3868_02420	COG0416	fatty acid biosynthetic process
D3868_02425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D3868_02445	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D3868_02455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D3868_02460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3868_02465	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D3868_02470	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3868_02470	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3868_02480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3868_02480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3868_02485	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D3868_02490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3868_02495	COG0698	ribose 5-phosphate isomerase
D3868_02515	COG3685	Protein conserved in bacteria
D3868_02535	COG2153	protein acetylation
D3868_02545	COG1793	dna ligase
D3868_02555	COG2313	pseudouridylate synthase activity
D3868_02565	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3868_02615	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_02635	COG1755	Isoprenylcysteine carboxyl methyltransferase
D3868_02640	COG3424	synthase
D3868_02660	COG3328	transposase activity
D3868_02665	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3868_02670	COG1492	cobalamin metabolic process
D3868_02730	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3868_02740	COG1024	Enoyl-CoA hydratase
D3868_02750	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3868_02755	COG3411	Ferredoxin
D3868_02775	COG3546	catalase activity
D3868_02780	COG2211	Major facilitator Superfamily
D3868_02785	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D3868_02830	COG0546	phosphoglycolate phosphatase activity
D3868_02845	COG3108	Peptidase M15
D3868_02855	COG1773	rubredoxin
D3868_02870	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3868_02875	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D3868_02925	COG2824	Alkylphosphonate utilization operon protein PhnA
D3868_02930	COG0840	transmembrane signaling receptor activity
D3868_02940	COG0243	molybdopterin cofactor binding
D3868_02945	COG2070	2-Nitropropane dioxygenase
D3868_02950	COG3706	GGDEF domain
D3868_02965	COG1410	methionine synthase
D3868_02965	COG0646	methionine synthase
D3868_02985	COG2853	Lipoprotein
D3868_03000	COG0488	(ABC) transporter
D3868_03005	COG1671	Belongs to the UPF0178 family
D3868_03010	COG2176	DNA-directed DNA polymerase activity
D3868_03010	COG5002	protein histidine kinase activity
D3868_03035	COG1640	4-alpha-glucanotransferase
D3868_03040	COG0745	RESPONSE REGULATOR receiver
D3868_03050	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3868_03055	COG0366	Alpha amylase catalytic
D3868_03070	COG1218	3'(2'),5'-bisphosphate nucleotidase
D3868_03075	COG2833	Protein of unknown function (DUF455)
D3868_03090	COG1960	acyl-CoA dehydrogenase activity
D3868_03095	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_03100	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_03105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_03110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3868_03150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_03160	COG1846	Transcriptional regulator
D3868_03165	COG2267	carboxylic ester hydrolase activity
D3868_03180	COG2226	methyltransferase
D3868_03200	COG1201	RNA secondary structure unwinding
D3868_03210	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D3868_03215	COG0415	Belongs to the DNA photolyase family
D3868_03225	COG0735	belongs to the Fur family
D3868_03230	COG0523	cobalamin synthesis protein
D3868_03240	COG0463	Glycosyl transferase, family 2
D3868_03245	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D3868_03250	COG1234	tRNA 3'-trailer cleavage
D3868_03265	COG0840	transmembrane signaling receptor activity
D3868_03280	COG4520	surface antigen
D3868_03285	COG0484	heat shock protein binding
D3868_03310	COG4191	Histidine kinase
D3868_03310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_03325	COG0784	Response regulator, receiver
D3868_03325	COG3437	response regulator, receiver
D3868_03350	COG2076	Multidrug Resistance protein
D3868_03355	COG0300	oxidoreductase activity
D3868_03360	COG1765	OsmC-like protein
D3868_03370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D3868_03380	COG0697	spore germination
D3868_03385	COG0367	asparagine synthase
D3868_03400	COG0438	transferase activity, transferring glycosyl groups
D3868_03405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3868_03425	COG2885	chlorophyll binding
D3868_03440	COG0848	biopolymer transport protein
D3868_03450	COG0824	Thioesterase
D3868_03455	COG2255	four-way junction helicase activity
D3868_03470	COG0217	transcriptional regulatory protein
D3868_03475	COG1692	metallophosphoesterase
D3868_03480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D3868_03525	COG1830	Aldolase
D3868_03530	COG0352	thiamine-phosphate diphosphorylase activity
D3868_03535	COG0730	response to heat
D3868_03540	COG2067	long-chain fatty acid transport protein
D3868_03545	COG0604	alcohol dehydrogenase
D3868_03550	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D3868_03555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D3868_03560	COG0483	inositol monophosphate 1-phosphatase activity
D3868_03580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3868_03590	COG0509	glycine decarboxylation via glycine cleavage system
D3868_03595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D3868_03610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D3868_03615	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D3868_03625	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_03630	COG0678	peroxiredoxin activity
D3868_03635	COG4232	protein-disulfide reductase activity
D3868_03640	COG1678	Uncharacterized ACR, COG1678
D3868_03650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3868_03655	COG0612	Peptidase, M16
D3868_03670	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D3868_03675	COG3346	SURF1 family
D3868_03695	COG0109	protoheme IX farnesyltransferase activity
D3868_03700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3868_03705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3868_03705	COG1565	acr, cog1565
D3868_03715	COG0312	modulator of DNA gyrase
D3868_03720	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D3868_03725	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3868_03735	COG5487	UPF0391 membrane protein
D3868_03745	COG0741	lytic transglycosylase activity
D3868_03775	COG0564	pseudouridine synthase activity
D3868_03780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3868_03790	COG0515	serine threonine protein kinase
D3868_03790	COG3266	domain, Protein
D3868_03795	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3868_03800	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D3868_03810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3868_03825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3868_03830	COG1295	ribonuclease BN
D3868_03835	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3868_03845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D3868_03855	COG0745	RESPONSE REGULATOR receiver
D3868_03865	COG0616	signal peptide processing
D3868_03880	COG0784	Response regulator, receiver
D3868_03880	COG2198	Histidine kinase
D3868_03880	COG5002	protein histidine kinase activity
D3868_03890	COG0390	transport system, permease component
D3868_03895	COG1136	(ABC) transporter
D3868_03895	COG0577	efflux transmembrane transporter activity
D3868_03905	COG0628	permease
D3868_03910	COG2205	protein histidine kinase activity
D3868_03920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3868_03930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3868_03935	COG0251	oxidation-reduction process
D3868_03945	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3868_03945	COG0551	DNA topoisomerase type I activity
D3868_03975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3868_03985	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3868_04000	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3868_04000	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D3868_04010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3868_04025	COG0505	Belongs to the CarA family
D3868_04035	COG1403	HNH endonuclease
D3868_04045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3868_04050	COG1393	Belongs to the ArsC family
D3868_04055	COG2890	protein-(glutamine-N5) methyltransferase activity
D3868_04060	COG1214	PFAM Peptidase M22, glycoprotease
D3868_04060	COG0456	acetyltransferase
D3868_04100	COG0538	isocitrate dehydrogenase activity
D3868_04110	COG3932	Exopolysaccharide synthesis, ExoD
D3868_04130	COG0473	3-isopropylmalate dehydrogenase activity
D3868_04160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3868_04180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3868_04195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3868_04215	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3868_04220	COG1684	flagellar biosynthetic protein fliR
D3868_04225	COG1987	bacterial-type flagellum assembly
D3868_04230	COG1677	Flagellar hook-basal body complex protein FliE
D3868_04235	COG1558	bacterial-type flagellum-dependent cell motility
D3868_04240	COG1815	bacterial-type flagellum-dependent cell motility
D3868_04245	COG2257	FlhB HrpN YscU SpaS Family
D3868_04260	COG1338	Plays a role in the flagellum-specific transport system
D3868_04275	COG1360	Flagellar Motor Protein
D3868_04315	COG4786	Flagellar basal body rod
D3868_04320	COG4786	Flagellar basal body rod
D3868_04330	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D3868_04340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D3868_04370	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3868_04395	COG0500	methyltransferase
D3868_04405	COG1132	(ABC) transporter
D3868_04410	COG0254	rRNA binding
D3868_04420	COG0071	Belongs to the small heat shock protein (HSP20) family
D3868_04440	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3868_04455	COG2186	Transcriptional regulator
D3868_04460	COG0563	adenylate kinase activity
D3868_04465	COG0201	protein transport
D3868_04470	COG0200	Binds to the 23S rRNA
D3868_04475	COG1841	ribosomal large subunit assembly
D3868_04490	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D3868_04495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D3868_04500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D3868_04510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D3868_04520	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D3868_04525	COG0255	Belongs to the universal ribosomal protein uL29 family
D3868_04530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D3868_04535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D3868_04540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D3868_04545	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D3868_04550	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D3868_04555	COG0089	rRNA binding
D3868_04560	COG0088	Forms part of the polypeptide exit tunnel
D3868_04570	COG0051	transcription antitermination factor activity, RNA binding
D3868_04575	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3868_04585	COG0049	tRNA binding
D3868_04600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D3868_04605	COG0085	RNA polymerase activity
D3868_04610	COG0222	ribosome binding
D3868_04615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D3868_04620	COG0081	regulation of translation
D3868_04625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D3868_04645	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3868_04710	COG0410	ABC transporter
D3868_04735	COG1940	carbohydrate kinase activity
D3868_04750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_04755	COG0410	ABC transporter
D3868_04760	COG0411	ABC transporter
D3868_04770	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_04795	COG0673	inositol 2-dehydrogenase activity
D3868_04805	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3868_04815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_04820	COG1309	transcriptional regulator
D3868_04830	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3868_04850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3868_04895	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3868_04900	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3868_04905	COG1530	ribonuclease E activity
D3868_04945	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D3868_04960	COG2264	protein methyltransferase activity
D3868_04970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D3868_04985	COG0312	modulator of DNA gyrase
D3868_04995	COG1597	lipid kinase activity
D3868_05005	COG0438	transferase activity, transferring glycosyl groups
D3868_05015	COG1519	Transferase
D3868_05020	COG1663	tetraacyldisaccharide 4'-kinase activity
D3868_05055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3868_05065	COG0590	tRNA wobble adenosine to inosine editing
D3868_05090	COG2703	oxygen carrier activity
D3868_05095	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3868_05125	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D3868_05135	COG2030	dehydratase
D3868_05140	COG0196	riboflavin kinase activity
D3868_05145	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3868_05150	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D3868_05155	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3868_05165	COG0612	Peptidase, M16
D3868_05170	COG0612	Peptidase, M16
D3868_05180	COG0166	Belongs to the GPI family
D3868_05220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3868_05235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3868_05260	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3868_05265	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3868_05290	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3868_05295	COG2188	Transcriptional regulator
D3868_05300	COG0667	Aldo Keto reductase
D3868_05325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3868_05330	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_05360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D3868_05370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3868_05375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3868_05405	COG1309	transcriptional regulator
D3868_05415	COG1518	maintenance of DNA repeat elements
D3868_05455	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3868_05470	COG0742	ribosomal rna small subunit methyltransferase
D3868_05475	COG1187	pseudouridine synthase activity
D3868_05480	COG3360	Dodecin
D3868_05485	COG0590	tRNA wobble adenosine to inosine editing
D3868_05500	COG1570	exodeoxyribonuclease VII activity
D3868_05510	COG0418	dihydroorotase activity
D3868_05515	COG0124	histidyl-tRNA synthetase
D3868_05555	COG1546	Belongs to the CinA family
D3868_05555	COG1058	Belongs to the CinA family
D3868_05560	COG1489	DNA binding
D3868_05585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D3868_05600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3868_05605	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3868_05615	COG2258	MOSC domain
D3868_05625	COG0583	DNA-binding transcription factor activity
D3868_05630	COG0047	phosphoribosylformylglycinamidine synthase activity
D3868_05635	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3868_05645	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D3868_05655	COG2962	Rard protein
D3868_05665	COG1902	pentaerythritol trinitrate reductase activity
D3868_05675	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D3868_05690	COG3279	Response regulator of the LytR AlgR family
D3868_05700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3868_05710	COG2205	protein histidine kinase activity
D3868_05720	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D3868_05750	COG0723	plastoquinol--plastocyanin reductase activity
D3868_05765	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3868_05775	COG0463	Glycosyl transferase, family 2
D3868_05780	COG0840	transmembrane signaling receptor activity
D3868_05800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D3868_05840	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D3868_05850	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D3868_05860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3868_05880	COG2010	Cytochrome c
D3868_05880	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3868_05895	COG0799	negative regulation of ribosome biogenesis
D3868_05900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D3868_05905	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D3868_05915	COG0793	Belongs to the peptidase S41A family
D3868_05925	COG1051	belongs to the nudix hydrolase family
D3868_05945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D3868_05955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3868_05975	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3868_05985	COG4974	Belongs to the 'phage' integrase family
D3868_05990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3868_06000	COG0596	Alpha beta hydrolase
D3868_06020	COG4191	Histidine kinase
D3868_06030	COG4106	trans-aconitate 2-methyltransferase activity
D3868_06050	COG2226	methyltransferase
D3868_06055	COG0126	phosphoglycerate kinase activity
D3868_06065	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D3868_06080	COG3474	cytochrome
D3868_06085	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3868_06110	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3868_06115	COG4166	transmembrane transport
D3868_06125	COG4166	transmembrane transport
D3868_06130	COG4174	ABC transporter (Permease)
D3868_06140	COG4239	(ABC) transporter, permease
D3868_06145	COG4172	Belongs to the ABC transporter superfamily
D3868_06180	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3868_06185	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3868_06210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3868_06230	COG4544	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
D3868_06250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3868_06255	COG0625	glutathione transferase activity
D3868_06265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_06270	COG0601	transmembrane transport
D3868_06295	COG0583	DNA-binding transcription factor activity
D3868_06310	COG5001	Diguanylate cyclase
D3868_06315	COG0625	glutathione transferase activity
D3868_06320	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3868_06330	COG0156	8-amino-7-oxononanoate synthase activity
D3868_06345	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_06360	COG1322	Protein conserved in bacteria
D3868_06365	COG1278	Cold shock
D3868_06375	COG0242	peptide deformylase activity
D3868_06380	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3868_06385	COG0101	tRNA pseudouridine synthase activity
D3868_06390	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_06405	COG2378	regulation of single-species biofilm formation
D3868_06410	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3868_06425	COG0335	large ribosomal subunit rRNA binding
D3868_06435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D3868_06440	COG0228	four-way junction DNA binding
D3868_06445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D3868_06500	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D3868_06515	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3868_06525	COG1131	(ABC) transporter
D3868_06535	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D3868_06550	COG0489	protein tyrosine kinase activity
D3868_06550	COG3206	protein involved in exopolysaccharide biosynthesis
D3868_06560	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D3868_06570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3868_06585	COG0438	transferase activity, transferring glycosyl groups
D3868_06625	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D3868_06635	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D3868_06640	COG0706	membrane insertase activity
D3868_06645	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D3868_06660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3868_06670	COG0598	Magnesium transport protein CorA
D3868_06685	COG0825	malonyl-CoA metabolic process
D3868_06695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3868_06700	COG4974	Belongs to the 'phage' integrase family
D3868_06720	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D3868_06725	COG0517	IMP dehydrogenase activity
D3868_06740	COG0271	Belongs to the BolA IbaG family
D3868_06770	COG1840	ABC-type Fe3 transport system, periplasmic component
D3868_06775	COG1741	Belongs to the pirin family
D3868_06785	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3868_06790	COG3706	GGDEF domain
D3868_06790	COG0745	RESPONSE REGULATOR receiver
D3868_06795	COG0135	phosphoribosylanthranilate isomerase activity
D3868_06815	COG2423	ornithine cyclodeaminase activity
D3868_06825	COG0776	regulation of translation
D3868_06835	COG0539	negative regulation of cytoplasmic translation
D3868_06850	COG0405	Gamma-glutamyltransferase
D3868_06865	COG1741	Belongs to the pirin family
D3868_06880	COG0745	RESPONSE REGULATOR receiver
D3868_06880	COG3706	GGDEF domain
D3868_06885	COG0784	Response regulator, receiver
D3868_06885	COG5002	protein histidine kinase activity
D3868_06885	COG2205	protein histidine kinase activity
D3868_06900	COG0463	Glycosyl transferase, family 2
D3868_06910	COG0071	Belongs to the small heat shock protein (HSP20) family
D3868_06950	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D3868_06975	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D3868_07000	COG3162	membrane
D3868_07020	COG1971	Probably functions as a manganese efflux pump
D3868_07025	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3868_07030	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3868_07035	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3868_07040	COG1987	bacterial-type flagellum assembly
D3868_07065	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D3868_07070	COG0513	Belongs to the DEAD box helicase family
D3868_07075	COG1970	mechanosensitive ion channel activity
D3868_07080	COG0653	protein targeting
D3868_07085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3868_07090	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D3868_07100	COG0494	nUDIX hydrolase
D3868_07105	COG0514	ATP-dependent DNA helicase (RecQ)
D3868_07135	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3868_07140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_07170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3868_07175	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3868_07180	COG0412	Dienelactone hydrolase
D3868_07185	COG0033	Phosphoglucomutase
D3868_07190	COG1278	Cold shock
D3868_07230	COG0444	Belongs to the ABC transporter superfamily
D3868_07240	COG0601	transmembrane transport
D3868_07250	COG0747	negative chemotaxis
D3868_07310	COG0671	phosphoesterase, PA-phosphatase related
D3868_07320	COG0784	Response regulator, receiver
D3868_07320	COG3437	response regulator, receiver
D3868_07335	COG1983	PspC domain protein
D3868_07345	COG1842	Phage shock protein A
D3868_07350	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D3868_07360	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3868_07375	COG3005	denitrification pathway
D3868_07380	COG1858	cytochrome C peroxidase
D3868_07385	COG0753	catalase activity
D3868_07390	COG0459	protein refolding
D3868_07395	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3868_07400	COG5425	PFAM Usg family protein
D3868_07405	COG3772	lysozyme
D3868_07410	COG0493	'glutamate synthase
D3868_07410	COG0543	2 iron, 2 sulfur cluster binding
D3868_07415	COG1612	heme a metabolic process
D3868_07445	COG0668	transmembrane transport
D3868_07450	COG0784	Response regulator, receiver
D3868_07450	COG3437	response regulator, receiver
D3868_07455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3868_07470	COG1396	sequence-specific DNA binding
D3868_07470	COG3800	Transcriptional regulator
D3868_07475	COG2224	Isocitrate lyase
D3868_07480	COG0693	protein deglycase activity
D3868_07485	COG2202	Pas domain
D3868_07485	COG2205	protein histidine kinase activity
D3868_07490	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3868_07495	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D3868_07495	COG0674	pyruvate-flavodoxin oxidoreductase activity
D3868_07500	COG1013	pyruvate-flavodoxin oxidoreductase activity
D3868_07520	COG3685	Protein conserved in bacteria
D3868_07535	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D3868_07550	COG0747	negative chemotaxis
D3868_07625	COG3436	PFAM IS66 Orf2 family protein
D3868_07630	COG3328	transposase activity
D3868_07655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D3868_07680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3868_07815	COG0464	growth
D3868_07820	COG3485	protocatechuate 3,4-dioxygenase
D3868_07855	COG2264	protein methyltransferase activity
D3868_07935	COG0347	Belongs to the P(II) protein family
D3868_07940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3868_07945	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D3868_07965	COG4181	ATPase activity
D3868_07975	COG3706	GGDEF domain
D3868_07985	COG0443	Heat shock 70 kDa protein
D3868_08010	COG0745	RESPONSE REGULATOR receiver
D3868_08020	COG1420	regulation of RNA biosynthetic process
D3868_08025	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D3868_08030	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D3868_08035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3868_08045	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D3868_08075	COG0792	nuclease activity
D3868_08080	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D3868_08100	COG1366	Belongs to the anti-sigma-factor antagonist family
D3868_08110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3868_08150	COG2205	protein histidine kinase activity
D3868_08150	COG0784	Response regulator, receiver
D3868_08160	COG0180	Tryptophanyl-tRNA synthetase
D3868_08165	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D3868_08175	COG3012	SEC-C Motif Domain Protein
D3868_08190	COG0110	maltose O-acetyltransferase activity
D3868_08195	COG1309	transcriptional regulator
D3868_08200	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_08215	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D3868_08220	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D3868_08225	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3868_08250	COG0438	transferase activity, transferring glycosyl groups
D3868_08255	COG3706	GGDEF domain
D3868_08270	COG1132	(ABC) transporter
D3868_08275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_08275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3868_08305	COG0747	negative chemotaxis
D3868_08310	COG0601	transmembrane transport
D3868_08315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_08325	COG1234	tRNA 3'-trailer cleavage
D3868_08345	COG0745	RESPONSE REGULATOR receiver
D3868_08410	COG1475	DNA binding
D3868_08415	COG1192	Involved in chromosome partitioning
D3868_08420	COG0357	Ribosomal RNA small subunit methyltransferase G
D3868_08425	COG0445	tRNA wobble uridine modification
D3868_08435	COG3411	Ferredoxin
D3868_08450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3868_08460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3868_08465	COG0237	dephospho-CoA kinase activity
D3868_08510	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D3868_08515	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D3868_08525	COG4395	Tim44
D3868_08530	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D3868_08585	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D3868_08595	COG2205	protein histidine kinase activity
D3868_08610	COG1556	Lactate utilization protein
D3868_08615	COG1139	Iron-sulfur cluster binding protein
D3868_08620	COG0247	lactate metabolic process
D3868_08625	COG0840	transmembrane signaling receptor activity
D3868_08640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3868_08645	COG1121	(ABC) transporter
D3868_08655	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D3868_08660	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3868_08670	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3868_08685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3868_08690	COG0730	response to heat
D3868_08720	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D3868_08730	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D3868_08765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3868_08770	COG1702	phosphate starvation-inducible protein PhoH
D3868_08780	COG1253	flavin adenine dinucleotide binding
D3868_08785	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D3868_08790	COG1396	sequence-specific DNA binding
D3868_08795	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D3868_08810	COG0779	Required for maturation of 30S ribosomal subunits
D3868_08835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D3868_08845	COG1185	polyribonucleotide nucleotidyltransferase activity
D3868_08855	COG2321	neutral zinc metallopeptidase
D3868_08865	COG1509	lysine 2,3-aminomutase activity
D3868_08870	COG0584	glycerophosphoryl diester phosphodiesterase
D3868_08885	COG1592	Rubrerythrin
D3868_08915	COG0039	L-malate dehydrogenase activity
D3868_08920	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D3868_08925	COG4166	transmembrane transport
D3868_08935	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3868_08940	COG2226	methyltransferase
D3868_08945	COG0457	Tetratricopeptide repeat
D3868_08945	COG0859	PFAM glycosyl transferase family 9
D3868_08955	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D3868_08965	COG1024	Enoyl-CoA hydratase
D3868_08970	COG0268	Binds directly to 16S ribosomal RNA
D3868_08975	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3868_08980	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3868_08985	COG3842	ATPase activity
D3868_09005	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_09010	COG1177	transmembrane transport
D3868_09025	COG2132	Multicopper oxidase
D3868_09075	COG2217	Heavy metal translocating P-type atpase
D3868_09085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_09090	COG0281	malic enzyme
D3868_09090	COG0280	phosphate acetyltransferase
D3868_09100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3868_09105	COG0573	inorganic phosphate transmembrane transporter activity
D3868_09115	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3868_09120	COG0704	Plays a role in the regulation of phosphate uptake
D3868_09125	COG0745	RESPONSE REGULATOR receiver
D3868_09140	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D3868_09150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3868_09160	COG0756	dUTP diphosphatase activity
D3868_09165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D3868_09170	COG2204	response regulator
D3868_09175	COG1278	Cold shock
D3868_09180	COG0784	Response regulator, receiver
D3868_09180	COG2205	protein histidine kinase activity
D3868_09180	COG5002	protein histidine kinase activity
D3868_09185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3868_09190	COG1321	iron dependent repressor
D3868_09190	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3868_09195	COG1121	(ABC) transporter
D3868_09200	COG0803	Belongs to the bacterial solute-binding protein 9 family
D3868_09235	COG2205	protein histidine kinase activity
D3868_09235	COG2202	Pas domain
D3868_09255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D3868_09260	COG1253	flavin adenine dinucleotide binding
D3868_09275	COG0477	Major facilitator Superfamily
D3868_09280	COG0583	DNA-binding transcription factor activity
D3868_09310	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3868_09315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3868_09325	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D3868_09330	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D3868_09335	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D3868_09350	COG3437	response regulator, receiver
D3868_09350	COG0784	Response regulator, receiver
D3868_09360	COG0583	DNA-binding transcription factor activity
D3868_09370	COG0481	GTPase activity
D3868_09380	COG0297	glycogen (starch) synthase activity
D3868_09385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3868_09390	COG0004	ammonium transporteR
D3868_09400	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
D3868_09420	COG1595	DNA-templated transcription, initiation
D3868_09430	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D3868_09445	COG0137	argininosuccinate synthase activity
D3868_09460	COG2897	thiosulfate sulfurtransferase activity
D3868_09465	COG3339	Conserved Protein
D3868_09470	COG0697	spore germination
D3868_09475	COG4235	cytochrome complex assembly
D3868_09480	COG3088	subunit of a heme lyase
D3868_09485	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3868_09490	COG1138	Cytochrome C-type biogenesis protein
D3868_09495	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D3868_09505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3868_09510	COG0583	DNA-binding transcription factor activity
D3868_09520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3868_09525	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D3868_09530	COG1573	uracil-dna glycosylase
D3868_09550	COG0598	Magnesium transport protein CorA
D3868_09555	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D3868_09560	COG1872	DUF167
D3868_09605	COG2985	domain, Protein
D3868_09610	COG4133	protoheme IX ABC transporter activity
D3868_09615	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3868_09640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D3868_09650	COG0802	atpase or kinase
D3868_09670	COG0745	RESPONSE REGULATOR receiver
D3868_09680	COG1252	NADH dehydrogenase
D3868_09685	COG2205	protein histidine kinase activity
D3868_09695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_09700	COG0133	tryptophan synthase activity
D3868_09710	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3868_09715	COG0285	dihydrofolate synthase activity
D3868_09730	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_09745	COG2205	protein histidine kinase activity
D3868_09750	COG0302	gtp cyclohydrolase
D3868_09760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D3868_09770	COG0302	gtp cyclohydrolase
D3868_09775	COG2967	ApaG domain
D3868_09810	COG0514	ATP-dependent DNA helicase (RecQ)
D3868_09875	COG0443	Heat shock 70 kDa protein
D3868_09880	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3868_09965	COG0582	viral genome integration into host DNA
D3868_09985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_10000	COG2205	protein histidine kinase activity
D3868_10000	COG0784	Response regulator, receiver
D3868_10000	COG5002	protein histidine kinase activity
D3868_10020	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3868_10025	COG4191	Histidine kinase
D3868_10025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_10035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3868_10045	COG2885	chlorophyll binding
D3868_10075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3868_10105	COG0181	hydroxymethylbilane synthase activity
D3868_10110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3868_10125	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D3868_10130	COG2350	Protein conserved in bacteria
D3868_10145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3868_10160	COG5508	conserved small protein
D3868_10165	COG0501	Belongs to the peptidase M48B family
D3868_10180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3868_10180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D3868_10190	COG0138	bifunctional purine biosynthesis protein purh
D3868_10215	COG2264	protein methyltransferase activity
D3868_10220	COG2902	Dehydrogenase
D3868_10225	COG3437	response regulator, receiver
D3868_10225	COG2770	Histidine kinase
D3868_10235	COG0840	transmembrane signaling receptor activity
D3868_10245	COG0679	Auxin Efflux Carrier
D3868_10250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3868_10265	COG3118	belongs to the thioredoxin family
D3868_10270	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3868_10275	COG2835	tetraacyldisaccharide 4'-kinase activity
D3868_10310	COG1285	pathogenesis
D3868_10315	COG2814	Major facilitator Superfamily
D3868_10325	COG0784	Response regulator, receiver
D3868_10325	COG2205	protein histidine kinase activity
D3868_10345	COG0395	ABC-type sugar transport system, permease component
D3868_10355	COG0625	glutathione transferase activity
D3868_10375	COG0513	Belongs to the DEAD box helicase family
D3868_10400	COG4191	Histidine kinase
D3868_10405	COG1366	Belongs to the anti-sigma-factor antagonist family
D3868_10415	COG0745	RESPONSE REGULATOR receiver
D3868_10435	COG0745	RESPONSE REGULATOR receiver
D3868_10435	COG3706	GGDEF domain
D3868_10440	COG0745	RESPONSE REGULATOR receiver
D3868_10440	COG3706	GGDEF domain
D3868_10450	COG1366	Belongs to the anti-sigma-factor antagonist family
D3868_10455	COG0840	transmembrane signaling receptor activity
D3868_10460	COG2201	protein-glutamate methylesterase activity
D3868_10465	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D3868_10475	COG0840	transmembrane signaling receptor activity
D3868_10480	COG0835	chemotaxis
D3868_10485	COG2198	Histidine kinase
D3868_10485	COG0643	Histidine kinase
D3868_10500	COG5002	protein histidine kinase activity
D3868_10510	COG5002	protein histidine kinase activity
D3868_10510	COG2176	DNA-directed DNA polymerase activity
D3868_10515	COG0745	RESPONSE REGULATOR receiver
D3868_10530	COG2917	probably involved in intracellular septation
D3868_10540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D3868_10545	COG0552	protein localization to endoplasmic reticulum
D3868_10550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3868_10555	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D3868_10605	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D3868_10620	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D3868_10625	COG3706	GGDEF domain
D3868_10630	COG2205	protein histidine kinase activity
D3868_10635	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3868_10650	COG0045	succinate-CoA ligase (ADP-forming) activity
D3868_10655	COG0039	L-malate dehydrogenase activity
D3868_10670	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D3868_10675	COG2076	Multidrug Resistance protein
D3868_10685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3868_10690	COG1199	ATP-dependent helicase activity
D3868_10690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3868_10695	COG0840	transmembrane signaling receptor activity
D3868_10705	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D3868_10715	COG2972	Histidine kinase
D3868_10715	COG0840	transmembrane signaling receptor activity
D3868_10730	COG2084	Dehydrogenase
D3868_10740	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3868_10775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3868_10860	COG0531	amino acid
D3868_10880	COG3485	protocatechuate 3,4-dioxygenase
D3868_10890	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D3868_10900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3868_10935	COG3328	transposase activity
D3868_10955	COG1074	ATP-dependent DNA helicase activity
D3868_10975	COG2814	Major facilitator Superfamily
D3868_11100	COG0167	dihydroorotate dehydrogenase activity
D3868_11110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D3868_11115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3868_11120	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3868_11190	COG3119	arylsulfatase activity
D3868_11225	COG0714	Associated with various cellular activities
D3868_11235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3868_11250	COG0583	DNA-binding transcription factor activity
D3868_11255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3868_11260	COG1024	Enoyl-CoA hydratase
D3868_11270	COG0154	amidase activity
D3868_11275	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_11285	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_11295	COG0411	ABC transporter
D3868_11325	COG1136	(ABC) transporter
D3868_11355	COG2304	oxidoreductase activity
D3868_11360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3868_11415	COG0783	Belongs to the Dps family
D3868_11425	COG0492	ferredoxin-NADP+ reductase activity
D3868_11440	COG3660	Nucleoside-diphosphate-sugar epimerase
D3868_11445	COG1522	sequence-specific DNA binding
D3868_11455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3868_11460	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3868_11485	COG1674	ftsk spoiiie
D3868_11505	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3868_11515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3868_11520	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_11525	COG1238	metal cluster binding
D3868_11545	COG1012	belongs to the aldehyde dehydrogenase family
D3868_11560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_11560	COG2205	protein histidine kinase activity
D3868_11570	COG1131	(ABC) transporter
D3868_11620	COG1116	anion transmembrane transporter activity
D3868_11660	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D3868_11675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3868_11680	COG2205	protein histidine kinase activity
D3868_11680	COG0784	Response regulator, receiver
D3868_11690	COG0745	RESPONSE REGULATOR receiver
D3868_11695	COG2766	serine protein kinase
D3868_11700	COG2718	Belongs to the UPF0229 family
D3868_11705	COG2719	SpoVR family
D3868_11720	COG1643	Atp-dependent helicase
D3868_11725	COG1116	anion transmembrane transporter activity
D3868_11745	COG0745	RESPONSE REGULATOR receiver
D3868_11770	COG0330	HflC and HflK could
D3868_11775	COG0628	permease
D3868_11785	COG3180	Ammonia monooxygenase
D3868_11790	COG2988	succinylglutamate desuccinylase activity
D3868_11830	COG2205	protein histidine kinase activity
D3868_11830	COG2202	Pas domain
D3868_11850	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3868_11860	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D3868_11890	COG2197	response regulator
D3868_11895	COG2197	response regulator
D3868_11915	COG2264	protein methyltransferase activity
D3868_11925	COG0006	proline dipeptidase activity
D3868_11925	COG0006	proline dipeptidase activity
D3868_11930	COG0745	RESPONSE REGULATOR receiver
D3868_11945	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3868_11950	COG0497	DNA recombination
D3868_11970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D3868_11985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D3868_11990	COG0849	cell division
D3868_11995	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D3868_12000	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3868_12005	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D3868_12010	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3868_12020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D3868_12035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3868_12045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3868_12065	COG2001	Belongs to the MraZ family
D3868_12090	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D3868_12105	COG0277	FAD linked oxidase domain protein
D3868_12110	COG2084	Dehydrogenase
D3868_12125	COG4191	Histidine kinase
D3868_12125	COG0784	Response regulator, receiver
D3868_12150	COG0142	geranyltranstransferase activity
D3868_12160	COG2890	protein-(glutamine-N5) methyltransferase activity
D3868_12180	COG0752	glycyl-tRNA synthetase alpha subunit
D3868_12185	COG0751	glycine-tRNA ligase activity
D3868_12190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3868_12195	COG1346	cytolysis
D3868_12200	COG1380	Effector of murein hydrolase LrgA
D3868_12205	COG1073	alpha beta
D3868_12230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3868_12240	COG2205	protein histidine kinase activity
D3868_12270	COG3409	Peptidoglycan-binding domain 1 protein
D3868_12270	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3868_12275	COG3108	Peptidase M15
D3868_12290	COG0840	transmembrane signaling receptor activity
D3868_12320	COG0511	ligase activity, forming carbon-carbon bonds
D3868_12325	COG0439	Biotin carboxylase
D3868_12330	COG3719	Belongs to the RNase T2 family
D3868_12355	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D3868_12380	COG1686	Belongs to the peptidase S11 family
D3868_12395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3868_12400	COG0746	molybdenum cofactor guanylyltransferase activity
D3868_12425	COG3383	formate dehydrogenase (NAD+) activity
D3868_12425	COG0243	molybdopterin cofactor binding
D3868_12430	COG0437	4 iron, 4 sulfur cluster binding
D3868_12455	COG0235	Class ii aldolase
D3868_12465	COG3384	dioxygenase
D3868_12475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3868_12480	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3868_12485	COG0356	it plays a direct role in the translocation of protons across the membrane
D3868_12495	COG1999	signal sequence binding
D3868_12505	COG0840	transmembrane signaling receptor activity
D3868_12510	COG1702	phosphate starvation-inducible protein PhoH
D3868_12515	COG0850	regulation of cytokinetic process
D3868_12520	COG2894	cell division
D3868_12525	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D3868_12540	COG0840	transmembrane signaling receptor activity
D3868_12550	COG4948	Mandelate Racemase Muconate Lactonizing
D3868_12560	COG1104	cysteine desulfurase activity
D3868_12570	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3868_12585	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D3868_12600	COG0840	transmembrane signaling receptor activity
D3868_12605	COG0840	transmembrane signaling receptor activity
D3868_12610	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3868_12615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3868_12620	COG1278	Cold shock
D3868_12655	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D3868_12710	COG5420	small protein containing a coiled-coil domain
D3868_12725	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D3868_12730	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D3868_12785	COG0121	glutamine amidotransferase
D3868_12800	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3868_12825	COG5554	nitrogen fixation
D3868_12840	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3868_12865	COG1309	transcriptional regulator
D3868_12875	COG1131	(ABC) transporter
D3868_12885	COG0842	Transport permease protein
D3868_12890	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D3868_12900	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D3868_12905	COG0277	FAD linked oxidase domain protein
D3868_12910	COG0277	FAD linked oxidase domain protein
D3868_12915	COG0247	lactate metabolic process
D3868_12935	COG1960	acyl-CoA dehydrogenase activity
D3868_12950	COG0277	FAD linked oxidase domain protein
D3868_12955	COG0009	L-threonylcarbamoyladenylate synthase
D3868_12960	COG1192	Involved in chromosome partitioning
D3868_12970	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3868_12975	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D3868_12990	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D3868_12995	COG2945	thiolester hydrolase activity
D3868_13000	COG1045	serine acetyltransferase
D3868_13015	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D3868_13020	COG0633	Ferredoxin
D3868_13025	COG0482	sulfurtransferase activity
D3868_13040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_13065	COG4221	oxidoreductase activity
D3868_13075	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D3868_13085	COG2205	protein histidine kinase activity
D3868_13085	COG0784	Response regulator, receiver
D3868_13095	COG0745	RESPONSE REGULATOR receiver
D3868_13120	COG0432	Pfam Uncharacterised protein family UPF0047
D3868_13130	COG2951	lytic endotransglycosylase activity
D3868_13150	COG1454	alcohol dehydrogenase
D3868_13180	COG0456	acetyltransferase
D3868_13195	COG0114	fumarate hydratase activity
D3868_13210	COG5002	protein histidine kinase activity
D3868_13210	COG5001	Diguanylate cyclase
D3868_13215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D3868_13230	COG0205	6-phosphofructokinase activity
D3868_13260	COG0288	reversible hydration of carbon dioxide
D3868_13320	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_13350	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D3868_13355	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3868_13360	COG0343	queuine tRNA-ribosyltransferase activity
D3868_13365	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D3868_13370	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3868_13375	COG0840	transmembrane signaling receptor activity
D3868_13450	COG2201	protein-glutamate methylesterase activity
D3868_13480	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3868_13485	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3868_13490	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D3868_13500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D3868_13505	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3868_13510	COG0242	peptide deformylase activity
D3868_13520	COG3070	regulator of competence-specific genes
D3868_13535	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D3868_13560	COG4120	Belongs to the binding-protein-dependent transport system permease family
D3868_13565	COG0410	ABC transporter
D3868_13575	COG0489	protein tyrosine kinase activity
D3868_13580	COG0330	HflC and HflK could
D3868_13585	COG0330	HflC and HflK could
D3868_13610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D3868_13615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3868_13620	COG0028	Belongs to the TPP enzyme family
D3868_13635	COG0704	Plays a role in the regulation of phosphate uptake
D3868_13640	COG2862	Uncharacterized protein family, UPF0114
D3868_13660	COG0768	penicillin binding
D3868_13665	COG0840	transmembrane signaling receptor activity
D3868_13700	COG0295	cytidine deaminase activity
D3868_13705	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3868_13710	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D3868_13725	COG0697	spore germination
D3868_13745	COG0411	ABC transporter
D3868_13760	COG0038	chloride channel
D3868_13770	COG2326	polyphosphate kinase activity
D3868_13775	COG0366	Alpha amylase catalytic
D3868_13785	COG2199	diguanylate cyclase activity
D3868_13785	COG2200	EAL domain
D3868_13785	COG2203	Gaf domain
D3868_13795	COG2135	peptidase activity
D3868_13805	COG0784	Response regulator, receiver
D3868_13810	COG2261	transglycosylase associated protein
D3868_13815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3868_13830	COG1733	regulation of RNA biosynthetic process
D3868_13840	COG2084	Dehydrogenase
D3868_13845	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_13860	COG0546	phosphoglycolate phosphatase activity
D3868_13875	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3868_13885	COG2832	Protein of unknown function (DUF454)
D3868_13890	COG1238	metal cluster binding
D3868_13895	COG3852	Histidine kinase
D3868_13900	COG0469	pyruvate kinase activity
D3868_13905	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D3868_13920	COG0203	ribosomal protein L17
D3868_13925	COG1238	metal cluster binding
D3868_13940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D3868_13955	COG0564	pseudouridine synthase activity
D3868_13960	COG1802	Transcriptional regulator
D3868_13965	COG3135	benzoate transporter
D3868_13970	COG0546	phosphoglycolate phosphatase activity
D3868_13995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3868_14000	COG1129	ABC transporter
D3868_14040	COG0745	RESPONSE REGULATOR receiver
D3868_14040	COG3706	GGDEF domain
D3868_14145	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D3868_14260	COG3547	Transposase (IS116 IS110 IS902 family)
D3868_14300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3868_14305	COG1414	Transcriptional regulator
D3868_14310	COG2376	Dihydroxyacetone kinase
D3868_14330	COG4977	sequence-specific DNA binding
D3868_14330	COG1917	Cupin 2, conserved barrel domain protein
D3868_14345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_14360	COG1063	alcohol dehydrogenase
D3868_14365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_14375	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_14380	COG2721	sulfolactate sulfo-lyase activity
D3868_14385	COG0246	Mannitol dehydrogenase
D3868_14410	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D3868_14415	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D3868_14420	COG0583	DNA-binding transcription factor activity
D3868_14425	COG2391	methyltransferase activity
D3868_14440	COG3842	ATPase activity
D3868_14445	COG4149	molybdate abc transporter
D3868_14450	COG1840	ABC-type Fe3 transport system, periplasmic component
D3868_14465	COG1686	Belongs to the peptidase S11 family
D3868_14510	COG1640	4-alpha-glucanotransferase
D3868_14525	COG0745	RESPONSE REGULATOR receiver
D3868_14540	COG0625	glutathione transferase activity
D3868_14545	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_14550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3868_14610	COG2099	Precorrin-6x reductase
D3868_14640	COG1797	cobyrinic acid a,c-diamide synthase activity
D3868_14645	COG0778	Nitroreductase
D3868_14650	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_14655	COG1309	transcriptional regulator
D3868_14660	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3868_14665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3868_14670	COG0737	Belongs to the 5'-nucleotidase family
D3868_14695	COG1749	Flagellar hook protein flgE
D3868_14720	COG0795	lipopolysaccharide-transporting ATPase activity
D3868_14725	COG0840	transmembrane signaling receptor activity
D3868_14730	COG1137	ATPase activity
D3868_14740	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_14745	COG1376	ErfK ybiS ycfS ynhG family protein
D3868_14765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3868_14800	COG2723	6-phospho-beta-galactosidase activity
D3868_14815	COG2086	electron transfer activity
D3868_14825	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3868_14835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3868_14850	COG0019	diaminopimelate decarboxylase activity
D3868_14870	COG0772	Belongs to the SEDS family
D3868_14880	COG0745	RESPONSE REGULATOR receiver
D3868_14900	COG1253	flavin adenine dinucleotide binding
D3868_14905	COG3932	Exopolysaccharide synthesis, ExoD
D3868_14910	COG2205	protein histidine kinase activity
D3868_14925	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D3868_14945	COG1657	PFAM Prenyltransferase squalene oxidase
D3868_14970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3868_14975	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3868_14980	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3868_14985	COG2080	2 iron, 2 sulfur cluster binding
D3868_14990	COG0583	DNA-binding transcription factor activity
D3868_15005	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D3868_15015	COG1960	acyl-CoA dehydrogenase activity
D3868_15055	COG0438	transferase activity, transferring glycosyl groups
D3868_15080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D3868_15090	COG0288	reversible hydration of carbon dioxide
D3868_15100	COG4948	Mandelate Racemase Muconate Lactonizing
D3868_15105	COG0583	DNA-binding transcription factor activity
D3868_15110	COG0625	glutathione transferase activity
D3868_15175	COG1335	isochorismatase
D3868_15180	COG4191	Histidine kinase
D3868_15185	COG4566	intracellular signal transduction
D3868_15225	COG0592	DNA-directed DNA polymerase activity
D3868_15230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D3868_15235	COG0187	DNA topoisomerase II activity
D3868_15255	COG1132	(ABC) transporter
D3868_15270	COG1120	ATPase activity
D3868_15275	COG4774	siderophore transport
D3868_15285	COG0583	DNA-binding transcription factor activity
D3868_15290	COG2814	Major facilitator Superfamily
D3868_15330	COG0840	transmembrane signaling receptor activity
D3868_15370	COG0765	amino acid transport
D3868_15395	COG2879	small protein
D3868_15400	COG1966	Carbon starvation protein
D3868_15430	COG1609	Transcriptional regulator
D3868_15435	COG4221	oxidoreductase activity
D3868_15450	COG1024	Enoyl-CoA hydratase
D3868_15470	COG1175	transmembrane transport
D3868_15480	COG3842	ATPase activity
D3868_15505	COG0683	leucine binding
D3868_15540	COG4615	Cyclic peptide transporter
D3868_15580	COG1320	monovalent cation:proton antiporter activity
D3868_15585	COG2212	antiporter activity
D3868_15590	COG1863	multisubunit Na H antiporter MnhE subunit
D3868_15595	COG0651	ATP synthesis coupled electron transport
D3868_15600	COG1006	Multisubunit Na H antiporter MnhC subunit
D3868_15605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3868_15605	COG2111	Na H antiporter
D3868_15615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3868_15620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3868_15625	COG2091	lysine biosynthetic process via aminoadipic acid
D3868_15635	COG2027	D-alanyl-D-alanine carboxypeptidase
D3868_15665	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D3868_15675	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3868_15685	COG0840	transmembrane signaling receptor activity
D3868_15700	COG0745	RESPONSE REGULATOR receiver
D3868_15705	COG2205	protein histidine kinase activity
D3868_15710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3868_15715	COG2864	formate dehydrogenase
D3868_15720	COG0437	4 iron, 4 sulfur cluster binding
D3868_15725	COG3383	formate dehydrogenase (NAD+) activity
D3868_15725	COG0243	molybdopterin cofactor binding
D3868_15745	COG0235	Class ii aldolase
D3868_15750	COG1942	4-Oxalocrotonate Tautomerase
D3868_15790	COG0420	3'-5' exonuclease activity
D3868_15800	COG3591	Belongs to the peptidase S1B family
D3868_15810	COG1192	Involved in chromosome partitioning
D3868_15815	COG1475	DNA binding
D3868_15830	COG0583	DNA-binding transcription factor activity
D3868_15835	COG0251	oxidation-reduction process
D3868_15850	COG3707	response regulator
D3868_15855	COG1116	anion transmembrane transporter activity
D3868_15865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3868_15870	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3868_15875	COG2146	nitrite reductase [NAD(P)H] activity
D3868_15885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3868_15885	COG1648	precorrin-2 dehydrogenase activity
D3868_15890	COG0791	NLP P60 protein
D3868_15900	COG1032	radical SAM domain protein
D3868_15950	COG1609	Transcriptional regulator
D3868_15955	COG0583	DNA-binding transcription factor activity
D3868_15970	COG3648	Uricase
D3868_15970	COG3195	allantoin biosynthetic process
D3868_15980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_16000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D3868_16040	COG3383	formate dehydrogenase (NAD+) activity
D3868_16040	COG0243	molybdopterin cofactor binding
D3868_16045	COG0437	4 iron, 4 sulfur cluster binding
D3868_16050	COG2864	formate dehydrogenase
D3868_16055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_16080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_16090	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_16120	COG0745	RESPONSE REGULATOR receiver
D3868_16125	COG3850	Histidine kinase
D3868_16125	COG0642	Histidine kinase
D3868_16175	COG2223	nitrite transmembrane transporter activity
D3868_16210	COG1137	ATPase activity
D3868_16215	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D3868_16220	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3868_16225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3868_16230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3868_16235	COG0527	aspartate kinase activity
D3868_16240	COG2070	2-Nitropropane dioxygenase
D3868_16255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D3868_16260	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D3868_16270	COG2852	Protein conserved in bacteria
D3868_16275	COG2890	protein-(glutamine-N5) methyltransferase activity
D3868_16295	COG0542	response to heat
D3868_16300	COG1272	protein, Hemolysin III
D3868_16305	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D3868_16320	COG0840	transmembrane signaling receptor activity
D3868_16325	COG5265	(ABC) transporter
D3868_16335	COG1703	isobutyryl-CoA mutase activity
D3868_16345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D3868_16355	COG2137	regulation of response to DNA damage stimulus
D3868_16360	COG0842	Transport permease protein
D3868_16365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3868_16370	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D3868_16375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D3868_16385	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D3868_16390	COG0671	phosphoesterase, PA-phosphatase related
D3868_16405	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3868_16410	COG4774	siderophore transport
D3868_16415	COG3128	pkhd-type hydroxylase
D3868_16430	COG4604	ABC transporter, ATP-binding protein
D3868_16435	COG4605	iron ion homeostasis
D3868_16440	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3868_16445	COG4607	ABC-type enterochelin transport system periplasmic component
D3868_16450	COG1695	Transcriptional regulator
D3868_16465	COG2205	protein histidine kinase activity
D3868_16465	COG0784	Response regulator, receiver
D3868_16465	COG5002	protein histidine kinase activity
D3868_16525	COG4206	TonB-dependent receptor
D3868_16575	COG3685	Protein conserved in bacteria
D3868_16610	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3868_16620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3868_16625	COG1959	2 iron, 2 sulfur cluster binding
D3868_16635	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D3868_16645	COG4208	sulfate ABC transporter
D3868_16650	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D3868_16695	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D3868_16700	COG0367	asparagine synthase
D3868_16705	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_16725	COG0438	transferase activity, transferring glycosyl groups
D3868_16730	COG0438	transferase activity, transferring glycosyl groups
D3868_16735	COG1215	transferase activity, transferring glycosyl groups
D3868_16755	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3868_16765	COG3693	PFAM glycoside hydrolase, family 10
D3868_16775	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D3868_16785	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3868_16790	COG0588	phosphoglycerate mutase activity
D3868_16815	COG5002	protein histidine kinase activity
D3868_16830	COG2011	ABC-type metal ion transport system permease component
D3868_16835	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D3868_16840	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_16845	COG1464	Belongs to the NlpA lipoprotein family
D3868_16860	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D3868_16870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3868_16885	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D3868_16895	COG1530	ribonuclease E activity
D3868_16900	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D3868_16930	COG1192	Involved in chromosome partitioning
D3868_16935	COG1522	sequence-specific DNA binding
D3868_16945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3868_16960	COG1309	transcriptional regulator
D3868_16975	COG5507	3-demethylubiquinone-9 3-methyltransferase
D3868_16985	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3868_16995	COG1917	Cupin 2, conserved barrel domain protein
D3868_16995	COG1396	sequence-specific DNA binding
D3868_17005	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_17010	COG2182	Extracellular solute-binding protein
D3868_17015	COG3842	ATPase activity
D3868_17020	COG0583	DNA-binding transcription factor activity
D3868_17030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3868_17060	COG0471	metal ion transport
D3868_17060	COG3273	potassium ion transport
D3868_17070	COG2814	Major facilitator Superfamily
D3868_17075	COG0583	DNA-binding transcription factor activity
D3868_17085	COG1566	PFAM secretion protein HlyD family protein
D3868_17130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3868_17145	COG0789	Transcriptional regulator
D3868_17150	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3868_17160	COG2860	membrane
D3868_17165	COG1741	Belongs to the pirin family
D3868_17190	COG2217	Heavy metal translocating P-type atpase
D3868_17205	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D3868_17220	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3868_17225	COG0741	lytic transglycosylase activity
D3868_17230	COG1573	uracil-dna glycosylase
D3868_17255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_17320	COG0840	transmembrane signaling receptor activity
D3868_17370	COG0583	DNA-binding transcription factor activity
D3868_17380	COG1283	sodium-dependent phosphate transmembrane transporter activity
D3868_17405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_17440	COG0306	phosphate transporter
D3868_17445	COG1392	Phosphate transport regulator
D3868_17455	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3868_17465	COG2223	nitrite transmembrane transporter activity
D3868_17500	COG0612	Peptidase, M16
D3868_17510	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D3868_17530	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3868_17540	COG0488	(ABC) transporter
D3868_17555	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3868_17560	COG0583	DNA-binding transcription factor activity
D3868_17565	COG3135	benzoate transporter
D3868_17575	COG0505	Belongs to the CarA family
D3868_17580	COG0586	Pfam SNARE associated Golgi protein
D3868_17615	COG2884	Cell division ATP-binding protein ftsE
D3868_17625	COG1309	transcriptional regulator
D3868_17650	COG5001	Diguanylate cyclase
D3868_17660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3868_17665	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3868_17670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_17680	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D3868_17690	COG2308	Evidence 4 Homologs of previously reported genes of
D3868_17695	COG1360	Flagellar Motor Protein
D3868_17700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3868_17705	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3868_17730	COG2198	Histidine kinase
D3868_17730	COG0643	Histidine kinase
D3868_17735	COG0835	chemotaxis
D3868_17740	COG2201	protein-glutamate methylesterase activity
D3868_17755	COG0583	DNA-binding transcription factor activity
D3868_17765	COG0745	RESPONSE REGULATOR receiver
D3868_17770	COG1157	protein secretion by the type III secretion system
D3868_17785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3868_17795	COG0455	bacterial-type flagellum organization
D3868_17800	COG0552	protein localization to endoplasmic reticulum
D3868_17805	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3868_17810	COG2204	response regulator
D3868_17815	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3868_17820	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3868_17830	COG1766	The M ring may be actively involved in energy transduction
D3868_17835	COG1396	sequence-specific DNA binding
D3868_17845	COG2205	protein histidine kinase activity
D3868_17850	COG2373	Large extracellular alpha-helical protein
D3868_17865	COG0183	Belongs to the thiolase family
D3868_17870	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3868_17870	COG1024	Enoyl-CoA hydratase
D3868_17875	COG1960	acyl-CoA dehydrogenase activity
D3868_17890	COG3047	cAMP biosynthetic process
D3868_17905	COG1196	nuclear chromosome segregation
D3868_17920	COG1194	a g-specific adenine glycosylase
D3868_17945	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D3868_17955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3868_17955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_17960	COG3012	SEC-C Motif Domain Protein
D3868_17970	COG0793	Belongs to the peptidase S41A family
D3868_17980	COG0309	Hydrogenase expression formation protein (HypE)
D3868_17985	COG0298	carbon dioxide binding
D3868_17990	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D3868_17995	COG1280	lysine exporter protein (LysE YggA)
D3868_18005	COG0375	protein maturation
D3868_18020	COG0298	carbon dioxide binding
D3868_18040	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3868_18045	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D3868_18050	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D3868_18055	COG5557	Pfam Polysulphide reductase, NrfD
D3868_18060	COG0437	4 iron, 4 sulfur cluster binding
D3868_18065	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D3868_18080	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D3868_18110	COG0625	glutathione transferase activity
D3868_18115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3868_18135	COG2813	Specifically methylates the guanine in position
D3868_18135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3868_18140	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3868_18150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3868_18155	COG0287	Prephenate dehydrogenase
D3868_18160	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D3868_18170	COG0583	DNA-binding transcription factor activity
D3868_18175	COG0450	alkyl hydroperoxide reductase
D3868_18180	COG3634	alkyl hydroperoxide reductase activity
D3868_18185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3868_18190	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3868_18195	COG2080	2 iron, 2 sulfur cluster binding
D3868_18205	COG1988	membrane-bound metal-dependent
D3868_18225	COG0745	RESPONSE REGULATOR receiver
D3868_18230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D3868_18235	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3868_18240	COG0540	Belongs to the ATCase OTCase family
D3868_18255	COG0583	DNA-binding transcription factor activity
D3868_18285	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D3868_18295	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3868_18300	COG0154	amidase activity
D3868_18305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3868_18310	COG4191	Histidine kinase
D3868_18340	COG1794	racemase activity, acting on amino acids and derivatives
D3868_18350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3868_18360	COG1268	BioY protein
D3868_18380	COG2204	response regulator
D3868_18385	COG4191	Histidine kinase
D3868_18390	COG1301	dicarboxylic acid transport
D3868_18395	COG0281	malic enzyme
D3868_18395	COG0280	phosphate acetyltransferase
D3868_18400	COG0859	PFAM glycosyl transferase family 9
D3868_18400	COG0457	Tetratricopeptide repeat
D3868_18410	COG2995	paraquat-inducible protein a
D3868_18415	COG3008	intermembrane lipid transfer
D3868_18415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3868_18425	COG1882	Formate acetyltransferase
D3868_18435	COG1595	DNA-templated transcription, initiation
D3868_18440	COG3806	Anti-sigma factor
D3868_18445	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3868_18465	COG3501	Rhs element vgr protein
D3868_18575	COG2862	Uncharacterized protein family, UPF0114
D3868_18605	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D3868_18660	COG5002	protein histidine kinase activity
D3868_18695	COG2267	carboxylic ester hydrolase activity
D3868_18710	COG1454	alcohol dehydrogenase
D3868_18715	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3868_18725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_18745	COG0148	phosphopyruvate hydratase activity
D3868_18780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3868_18780	COG0357	Ribosomal RNA small subunit methyltransferase G
D3868_18790	COG3813	Protein conserved in bacteria
D3868_18800	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D3868_18825	COG1247	-acetyltransferase
D3868_18830	COG0519	Catalyzes the synthesis of GMP from XMP
D3868_18845	COG3328	transposase activity
D3868_18855	COG0583	DNA-binding transcription factor activity
D3868_18875	COG0667	Aldo Keto reductase
D3868_18880	COG0583	DNA-binding transcription factor activity
D3868_18935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D3868_18940	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3868_18945	COG1127	ABC transporter
D3868_18965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3868_18970	COG1271	oxidase subunit
D3868_18975	COG1294	oxidase, subunit
D3868_19005	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_19030	COG2089	acid synthase
D3868_19035	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D3868_19065	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3868_19085	COG0457	Tetratricopeptide repeat
D3868_19085	COG0859	PFAM glycosyl transferase family 9
D3868_19100	COG0859	PFAM glycosyl transferase family 9
D3868_19100	COG0457	Tetratricopeptide repeat
D3868_19120	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3868_19150	COG0784	Response regulator, receiver
D3868_19180	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3868_19190	COG1228	amidohydrolase
D3868_19205	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D3868_19220	COG2226	methyltransferase
D3868_19235	COG0747	negative chemotaxis
D3868_19240	COG0601	transmembrane transport
D3868_19245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_19250	COG0444	Belongs to the ABC transporter superfamily
D3868_19255	COG4608	Belongs to the ABC transporter superfamily
D3868_19290	COG1666	GTP binding
D3868_19310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3868_19315	COG5001	Diguanylate cyclase
D3868_19345	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3868_19350	COG1132	(ABC) transporter
D3868_19355	COG4191	Histidine kinase
D3868_19380	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D3868_19390	COG2264	protein methyltransferase activity
D3868_19395	COG0583	DNA-binding transcription factor activity
D3868_19400	COG0655	NAD(P)H dehydrogenase (quinone) activity
D3868_19405	COG0435	Glutathione S-transferase
D3868_19415	COG2197	response regulator
D3868_19425	COG0492	ferredoxin-NADP+ reductase activity
D3868_19455	COG0501	Belongs to the peptidase M48B family
D3868_19465	COG3038	cytochrome b561
D3868_19470	COG3240	lipase activity
D3868_19485	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3868_19495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3868_19505	COG1846	Transcriptional regulator
D3868_19515	COG3920	Histidine kinase
D3868_19530	COG1758	RNA polymerase activity
D3868_19545	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D3868_19550	COG0736	holo-[acyl-carrier-protein] synthase activity
D3868_19555	COG0681	Belongs to the peptidase S26 family
D3868_19560	COG0571	ribonuclease III activity
D3868_19565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D3868_19575	COG3768	UPF0283 membrane protein
D3868_19595	COG0740	serine-type endopeptidase activity
D3868_19600	COG1216	Glycosyl transferase, family 2
D3868_19605	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3868_19610	COG1566	PFAM secretion protein HlyD family protein
D3868_19615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_19625	COG2308	Evidence 4 Homologs of previously reported genes of
D3868_19625	COG2307	Protein conserved in bacteria
D3868_19630	COG2010	Cytochrome c
D3868_19650	COG2017	converts alpha-aldose to the beta-anomer
D3868_19655	COG2815	serine threonine protein kinase
D3868_19655	COG0515	serine threonine protein kinase
D3868_19660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D3868_19690	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D3868_19700	COG0513	Belongs to the DEAD box helicase family
D3868_19710	COG0596	Alpha beta hydrolase
D3868_19720	COG0187	DNA topoisomerase II activity
D3868_19725	COG1607	acyl-coa hydrolase
D3868_19730	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D3868_19735	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3868_19740	COG0022	dehydrogenase e1 component
D3868_19740	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3868_19745	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3868_19750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3868_19755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3868_19760	COG2867	negative regulation of translational initiation
D3868_19765	COG1546	Belongs to the CinA family
D3868_19765	COG1058	Belongs to the CinA family
D3868_19800	COG2204	response regulator
D3868_19810	COG0569	domain protein
D3868_19825	COG1923	regulation of RNA biosynthetic process
D3868_19830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3868_19845	COG0483	inositol monophosphate 1-phosphatase activity
D3868_19860	COG3956	TIGRFAM MazG family protein
D3868_19865	COG3260	NADH ubiquinone oxidoreductase 20
D3868_19870	COG0649	NAD binding
D3868_19875	COG0651	ATP synthesis coupled electron transport
D3868_19885	COG0650	Formate hydrogenlyase subunit 4
D3868_19890	COG0651	ATP synthesis coupled electron transport
D3868_19900	COG2183	response to ionizing radiation
D3868_19910	COG1280	lysine exporter protein (LysE YggA)
D3868_19940	COG0393	Putative heavy-metal-binding
D3868_19945	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3868_19960	COG4166	transmembrane transport
D3868_19965	COG0625	glutathione transferase activity
D3868_19970	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3868_19975	COG0366	Alpha amylase catalytic
D3868_19995	COG0840	transmembrane signaling receptor activity
D3868_20030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_20040	COG0583	DNA-binding transcription factor activity
D3868_20045	COG4336	lyase activity
D3868_20060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_20065	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D3868_20070	COG1984	allophanate hydrolase subunit 2
D3868_20075	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D3868_20090	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D3868_20100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3868_20105	COG0058	SHG alpha-glucan phosphorylase activity
D3868_20160	COG5002	protein histidine kinase activity
D3868_20165	COG0745	RESPONSE REGULATOR receiver
D3868_20200	COG0719	Fe-S assembly protein
D3868_20205	COG0396	ATPase activity
D3868_20210	COG0719	Fe-S assembly protein
D3868_20215	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3868_20220	COG0822	iron-sulfur transferase activity
D3868_20230	COG0316	Belongs to the HesB IscA family
D3868_20240	COG0308	aminopeptidase N
D3868_20260	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3868_20295	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3868_20300	COG0697	spore germination
D3868_20310	COG2814	Major facilitator Superfamily
D3868_20315	COG0583	DNA-binding transcription factor activity
D3868_20330	COG3383	formate dehydrogenase (NAD+) activity
D3868_20335	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3868_20350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3868_20355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3868_20375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3868_20385	COG0129	dihydroxy-acid dehydratase activity
D3868_20420	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D3868_20425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3868_20430	COG0534	Mate efflux family protein
D3868_20465	COG0629	single-stranded DNA binding
D3868_20470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3868_20490	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D3868_20505	COG1562	ergosterol biosynthetic process
D3868_20510	COG1562	ergosterol biosynthetic process
D3868_20515	COG1233	COG1233 Phytoene dehydrogenase and related
D3868_20525	COG3737	Protein of unknown function (DUF498/DUF598)
D3868_20555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3868_20565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3868_20570	COG3706	GGDEF domain
D3868_20570	COG0745	RESPONSE REGULATOR receiver
D3868_20575	COG0805	protein transport
D3868_20580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3868_20585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3868_20590	COG3842	ATPase activity
D3868_20595	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D3868_20600	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D3868_20605	COG1994	Peptidase M50
D3868_20610	COG1472	Belongs to the glycosyl hydrolase 3 family
D3868_20625	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D3868_20630	COG0316	Belongs to the HesB IscA family
D3868_20635	COG0708	Exodeoxyribonuclease III
D3868_20650	COG3706	GGDEF domain
D3868_20650	COG0745	RESPONSE REGULATOR receiver
D3868_20655	COG0066	3-isopropylmalate dehydratase activity
D3868_20660	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3868_20670	COG1335	isochorismatase
D3868_20705	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_20710	COG0683	leucine binding
D3868_20715	COG2188	Transcriptional regulator
D3868_20720	COG0717	Belongs to the dCTP deaminase family
D3868_20735	COG0730	response to heat
D3868_20740	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_20760	COG0303	'Molybdopterin
D3868_20765	COG0765	amino acid transport
D3868_20770	COG0765	amino acid transport
D3868_20780	COG1126	abc transporter atp-binding protein
D3868_20785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3868_20790	COG1609	Transcriptional regulator
D3868_20805	COG3265	gluconokinase activity
D3868_20810	COG1609	Transcriptional regulator
D3868_20815	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D3868_20820	COG1024	Enoyl-CoA hydratase
D3868_20835	COG1652	LysM domain
D3868_20845	COG1174	glycine betaine transport
D3868_20850	COG1125	glycine betaine transport
D3868_20855	COG1174	glycine betaine transport
D3868_20860	COG1732	Glycine betaine
D3868_20865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3868_20875	COG3842	ATPase activity
D3868_20885	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_20890	COG0581	inorganic phosphate transmembrane transporter activity
D3868_20925	COG0745	RESPONSE REGULATOR receiver
D3868_20930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_20930	COG2205	protein histidine kinase activity
D3868_20965	COG2814	Major facilitator Superfamily
D3868_20985	COG0758	DNA mediated transformation
D3868_20990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3868_21005	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3868_21015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_21020	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_21025	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3868_21030	COG0837	glucose binding
D3868_21030	COG1737	Transcriptional regulator
D3868_21035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3868_21045	COG0386	Belongs to the glutathione peroxidase family
D3868_21050	COG2814	Major facilitator Superfamily
D3868_21060	COG3264	Mechanosensitive ion channel
D3868_21060	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D3868_21110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3868_21115	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D3868_21125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_21130	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3868_21145	COG0437	4 iron, 4 sulfur cluster binding
D3868_21180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3868_21185	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3868_21190	COG1845	cytochrome c oxidase, subunit III
D3868_21235	COG0601	transmembrane transport
D3868_21245	COG0444	Belongs to the ABC transporter superfamily
D3868_21270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D3868_21275	COG1902	pentaerythritol trinitrate reductase activity
D3868_21275	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3868_21290	COG2204	response regulator
D3868_21290	COG5564	TIM-barrel signal transduction protein
D3868_21295	COG5441	Belongs to the UPF0261 family
D3868_21300	COG5564	TIM-barrel signal transduction protein
D3868_21330	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3868_21355	COG0557	exoribonuclease II activity
D3868_21360	COG0793	Belongs to the peptidase S41A family
D3868_21365	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D3868_21370	COG0745	RESPONSE REGULATOR receiver
D3868_21370	COG3706	GGDEF domain
D3868_21380	COG2205	protein histidine kinase activity
D3868_21380	COG2202	Pas domain
D3868_21385	COG5002	protein histidine kinase activity
D3868_21385	COG3447	MASE1 domain protein
D3868_21385	COG5001	Diguanylate cyclase
D3868_21405	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D3868_21410	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D3868_21420	COG0248	Ppx GppA phosphatase
D3868_21425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3868_21435	COG3025	triphosphatase activity
D3868_21440	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_21450	COG0628	permease
D3868_21455	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3868_21465	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D3868_21470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D3868_21485	COG0105	UTP biosynthetic process
D3868_21490	COG0488	(ABC) transporter
D3868_21495	COG3932	Exopolysaccharide synthesis, ExoD
D3868_21500	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3868_21505	COG0300	oxidoreductase activity
D3868_21510	COG1561	YicC-like family, N-terminal region
D3868_21535	COG0741	lytic transglycosylase activity
D3868_21550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D3868_21555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3868_21565	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3868_21570	COG2927	DNA polymerase III (CHI subunit)
D3868_21575	COG2205	protein histidine kinase activity
D3868_21595	COG0556	nucleotide-excision repair
D3868_21610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3868_21615	COG1846	Transcriptional regulator
D3868_21620	COG1278	Cold shock
D3868_21630	COG0745	RESPONSE REGULATOR receiver
D3868_21635	COG2205	protein histidine kinase activity
D3868_21645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_21670	COG0411	ABC transporter
D3868_21675	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_21705	COG0183	Belongs to the thiolase family
D3868_21715	COG1082	Xylose isomerase domain protein TIM barrel
D3868_21735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_21740	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_21750	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3868_21760	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3868_21760	COG0596	Alpha beta hydrolase
D3868_21765	COG0022	dehydrogenase e1 component
D3868_21770	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3868_21775	COG3199	ATP-NAD kinase
D3868_21780	COG3284	Transcriptional regulator
D3868_21795	COG1396	sequence-specific DNA binding
D3868_21830	COG0300	oxidoreductase activity
D3868_21845	COG0583	DNA-binding transcription factor activity
D3868_21865	COG1846	Transcriptional regulator
D3868_21870	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_21880	COG0583	DNA-binding transcription factor activity
D3868_21895	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D3868_21905	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D3868_21925	COG0425	Belongs to the sulfur carrier protein TusA family
D3868_21935	COG0640	Transcriptional regulator
D3868_21955	COG2857	Cytochrome c1
D3868_21955	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D3868_21970	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D3868_21975	COG0408	coproporphyrinogen oxidase activity
D3868_21980	COG0617	tRNA 3'-terminal CCA addition
D3868_22000	COG0714	Associated with various cellular activities
D3868_22100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3868_22105	COG1960	acyl-CoA dehydrogenase activity
D3868_22110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3868_22115	COG1764	response to oxidative stress
D3868_22160	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_22185	COG0583	DNA-binding transcription factor activity
D3868_22195	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D3868_22215	COG1573	uracil-dna glycosylase
D3868_22240	COG2010	Cytochrome c
D3868_22300	COG1131	(ABC) transporter
D3868_22320	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
D3868_22325	COG1229	Formylmethanofuran dehydrogenase subunit A
D3868_22335	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3868_22345	COG0702	epimerase
D3868_22355	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
D3868_22360	COG0189	ligase activity
D3868_22370	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
D3868_22465	COG1414	Transcriptional regulator
D3868_22470	COG1024	Enoyl-CoA hydratase
D3868_22480	COG3842	ATPase activity
D3868_22485	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_22490	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_22495	COG0840	transmembrane signaling receptor activity
D3868_22520	COG0402	S-adenosylhomocysteine deaminase activity
D3868_22525	COG1116	anion transmembrane transporter activity
D3868_22530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_22550	COG3842	ATPase activity
D3868_22555	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3868_22560	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_22570	COG2351	hydroxyisourate hydrolase activity
D3868_22580	COG0154	amidase activity
D3868_22585	COG5002	protein histidine kinase activity
D3868_22585	COG0784	Response regulator, receiver
D3868_22620	COG3387	PFAM Glycoside hydrolase 15-related
D3868_22635	COG2197	response regulator
D3868_22640	COG2197	response regulator
D3868_22655	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3868_22660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3868_22665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3868_22670	COG0438	transferase activity, transferring glycosyl groups
D3868_22690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3868_22710	COG0438	transferase activity, transferring glycosyl groups
D3868_22725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3868_22740	COG0583	DNA-binding transcription factor activity
D3868_22745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_22760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_22765	COG4172	Belongs to the ABC transporter superfamily
D3868_22785	COG0028	Belongs to the TPP enzyme family
D3868_22790	COG3246	L-lysine catabolic process to acetate
D3868_22805	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_22810	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_22820	COG1850	ribulose-bisphosphate carboxylase activity
D3868_22830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_22835	COG2204	response regulator
D3868_22860	COG0670	Belongs to the BI1 family
D3868_22875	COG4459	periplasmic nitrate reductase
D3868_22900	COG3005	denitrification pathway
D3868_22935	COG1845	cytochrome c oxidase, subunit III
D3868_22940	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3868_22945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3868_22950	COG0477	Major facilitator Superfamily
D3868_22960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3868_22965	COG0406	alpha-ribazole phosphatase activity
D3868_22965	COG0328	RNA-DNA hybrid ribonuclease activity
D3868_22990	COG0392	lysyltransferase activity
D3868_22995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3868_23045	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3868_23065	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3868_23070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_23090	COG1846	Transcriptional regulator
D3868_23095	COG1764	response to oxidative stress
D3868_23115	COG2113	Glycine betaine
D3868_23120	COG4176	ABC-type proline glycine betaine transport system permease component
D3868_23125	COG4175	Glycine betaine
D3868_23130	COG0339	signal peptide processing
D3868_23160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_23215	COG0840	transmembrane signaling receptor activity
D3868_23220	COG4178	(ABC) transporter
D3868_23230	COG1475	DNA binding
D3868_23235	COG1192	Involved in chromosome partitioning
D3868_23240	COG4783	chaperone-mediated protein folding
D3868_23260	COG3622	Belongs to the hyi family
D3868_23270	COG1215	transferase activity, transferring glycosyl groups
D3868_23285	COG3307	-O-antigen
D3868_23290	COG0489	protein tyrosine kinase activity
D3868_23290	COG3206	protein involved in exopolysaccharide biosynthesis
D3868_23320	COG1216	Glycosyl transferase, family 2
D3868_23390	COG0640	Transcriptional regulator
D3868_23395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3868_23415	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3868_23425	COG4566	intracellular signal transduction
D3868_23440	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_23460	COG1994	Peptidase M50
D3868_23460	COG0517	IMP dehydrogenase activity
D3868_23470	COG1959	2 iron, 2 sulfur cluster binding
D3868_23480	COG1522	sequence-specific DNA binding
D3868_23495	COG0583	DNA-binding transcription factor activity
D3868_23500	COG1802	Transcriptional regulator
D3868_23505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_23515	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_23520	COG2354	Protein conserved in bacteria
D3868_23540	COG1418	mRNA catabolic process
D3868_23545	COG1131	(ABC) transporter
D3868_23550	COG0842	Transport permease protein
D3868_23555	COG3791	Glutathione-dependent formaldehyde-activating
D3868_23560	COG0154	amidase activity
D3868_23565	COG0154	amidase activity
D3868_23570	COG1335	isochorismatase
D3868_23575	COG0747	negative chemotaxis
D3868_23595	COG4608	Belongs to the ABC transporter superfamily
D3868_23600	COG1335	isochorismatase
D3868_23605	COG3180	Ammonia monooxygenase
D3868_23610	COG1802	Transcriptional regulator
D3868_23620	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D3868_23625	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D3868_23630	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D3868_23635	COG2205	protein histidine kinase activity
D3868_23645	COG0861	Integral membrane protein TerC family
D3868_23655	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_23660	COG2353	YceI-like domain
D3868_23680	COG4566	intracellular signal transduction
D3868_23685	COG4566	intracellular signal transduction
D3868_23690	COG4191	Histidine kinase
D3868_23700	COG1538	Outer membrane efflux protein
D3868_23705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_23710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_23715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_23725	COG0427	acetyl-CoA hydrolase
D3868_23750	COG0243	molybdopterin cofactor binding
D3868_23840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3868_23850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_23855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_23865	COG0628	permease
D3868_23870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3868_23880	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D3868_23910	COG1192	Involved in chromosome partitioning
D3868_23920	COG1653	transport
D3868_23935	COG3842	ATPase activity
D3868_23960	COG0840	transmembrane signaling receptor activity
D3868_23960	COG0840	transmembrane signaling receptor activity
D3868_23975	COG0411	ABC transporter
D3868_23985	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_24000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_24005	COG1473	amidohydrolase
D3868_24050	COG1971	Probably functions as a manganese efflux pump
D3868_24055	COG0840	transmembrane signaling receptor activity
D3868_24055	COG3290	protein histidine kinase activity
D3868_24080	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_24085	COG0366	Alpha amylase catalytic
D3868_24090	COG2388	GCN5-related N-acetyl-transferase
D3868_24105	COG4191	Histidine kinase
D3868_24105	COG0784	Response regulator, receiver
D3868_24110	COG5002	protein histidine kinase activity
D3868_24110	COG0784	Response regulator, receiver
D3868_24135	COG0840	transmembrane signaling receptor activity
D3868_24170	COG4615	Cyclic peptide transporter
D3868_24195	COG0586	Pfam SNARE associated Golgi protein
D3868_24220	COG0395	ABC-type sugar transport system, permease component
D3868_24235	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3868_24240	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_24265	COG2095	MarC family integral membrane protein
D3868_24280	COG0840	transmembrane signaling receptor activity
D3868_24285	COG0835	chemotaxis
D3868_24290	COG2201	protein-glutamate methylesterase activity
D3868_24300	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3868_24305	COG0745	RESPONSE REGULATOR receiver
D3868_24305	COG3706	GGDEF domain
D3868_24310	COG0643	Histidine kinase
D3868_24310	COG2198	Histidine kinase
D3868_24320	COG2197	response regulator
D3868_24335	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_24345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3868_24375	COG2204	response regulator
D3868_24385	COG2985	domain, Protein
D3868_24400	COG3842	ATPase activity
D3868_24415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_24425	COG0251	oxidation-reduction process
D3868_24445	COG0747	negative chemotaxis
D3868_24455	COG0583	DNA-binding transcription factor activity
D3868_24465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3868_24470	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3868_24470	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3868_24475	COG1660	Displays ATPase and GTPase activities
D3868_24490	COG0642	Histidine kinase
D3868_24495	COG0745	RESPONSE REGULATOR receiver
D3868_24510	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D3868_24525	COG0739	heme binding
D3868_24575	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3868_24595	COG1216	Glycosyl transferase, family 2
D3868_24595	COG1442	glycosyl transferase family 8
D3868_24605	COG4178	(ABC) transporter
D3868_24615	COG2723	6-phospho-beta-galactosidase activity
D3868_24620	COG2723	6-phospho-beta-galactosidase activity
D3868_24640	COG2819	hydrolase of the alpha beta superfamily
D3868_24675	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D3868_24680	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3868_24685	COG1960	acyl-CoA dehydrogenase activity
D3868_24690	COG0183	Belongs to the thiolase family
D3868_24695	COG1960	acyl-CoA dehydrogenase activity
D3868_24705	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_24725	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_24740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3868_24745	COG0747	negative chemotaxis
D3868_24755	COG2201	protein-glutamate methylesterase activity
D3868_24775	COG4771	TonB-dependent receptor
D3868_24800	COG1169	isochorismate synthase
D3868_24805	COG1021	2,3-dihydroxybenzoate-AMP ligase
D3868_24810	COG1535	isochorismatase
D3868_24810	COG3433	isochorismatase activity
D3868_24815	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_24825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3868_24830	COG2382	esterase
D3868_24840	COG1960	acyl-CoA dehydrogenase activity
D3868_24845	COG2186	Transcriptional regulator
D3868_24850	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_24855	COG1309	transcriptional regulator
D3868_24865	COG1846	Transcriptional regulator
D3868_24870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D3868_24880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_24900	COG2226	methyltransferase
D3868_24965	COG0861	Integral membrane protein TerC family
D3868_24975	COG2239	Acts as a magnesium transporter
D3868_24980	COG1802	Transcriptional regulator
D3868_25020	COG0367	asparagine synthase
D3868_25025	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3868_25025	COG2918	glutathione biosynthetic process
D3868_25030	COG1363	Peptidase, m42
D3868_25040	COG1966	Carbon starvation protein
D3868_25050	COG3275	phosphorelay sensor kinase activity
D3868_25090	COG0848	biopolymer transport protein
D3868_25100	COG4566	intracellular signal transduction
D3868_25105	COG4191	Histidine kinase
D3868_25110	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3868_25145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_25155	COG0784	Response regulator, receiver
D3868_25155	COG5002	protein histidine kinase activity
D3868_25155	COG2205	protein histidine kinase activity
D3868_25180	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_25205	COG0800	Aldolase
D3868_25210	COG3734	2-keto-3-deoxy-galactonokinase
D3868_25215	COG1414	Transcriptional regulator
D3868_25220	COG0542	response to heat
D3868_25225	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3868_25235	COG2186	Transcriptional regulator
D3868_25240	COG1620	l-lactate permease
D3868_25245	COG0277	FAD linked oxidase domain protein
D3868_25250	COG0247	lactate metabolic process
D3868_25255	COG1139	Iron-sulfur cluster binding protein
D3868_25295	COG0668	transmembrane transport
D3868_25365	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3868_25400	COG1902	pentaerythritol trinitrate reductase activity
D3868_25425	COG0673	inositol 2-dehydrogenase activity
D3868_25435	COG1053	succinate dehydrogenase
D3868_25440	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3868_25445	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_25465	COG0410	ABC transporter
D3868_25475	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_25490	COG0625	glutathione transferase activity
D3868_25500	COG3316	Transposase and inactivated derivatives
D3868_25505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3868_25570	COG4372	Transposase
D3868_25575	COG3436	PFAM IS66 Orf2 family protein
D3868_25615	COG0604	alcohol dehydrogenase
D3868_25620	COG1024	Enoyl-CoA hydratase
D3868_25625	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_25635	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_25645	COG3842	ATPase activity
D3868_25675	COG0798	PFAM Bile acid sodium symporter
D3868_25680	COG0431	NADPH-dependent FMN reductase
D3868_25710	COG1120	ATPase activity
D3868_25730	COG4774	siderophore transport
D3868_25745	COG4774	siderophore transport
D3868_25750	COG1595	DNA-templated transcription, initiation
D3868_25775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_25780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3868_25785	COG0405	Gamma-glutamyltransferase
D3868_25790	COG4336	lyase activity
D3868_25795	COG0251	oxidation-reduction process
D3868_25800	COG1522	sequence-specific DNA binding
D3868_25830	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_25850	COG2610	gluconate transmembrane transporter activity
D3868_25880	COG3920	Histidine kinase
D3868_25910	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_25915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3868_25930	COG0071	Belongs to the small heat shock protein (HSP20) family
D3868_25940	COG1802	Transcriptional regulator
D3868_25940	COG4626	Terminase
D3868_25950	COG3316	Transposase and inactivated derivatives
D3868_26040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D3868_26060	COG0356	it plays a direct role in the translocation of protons across the membrane
D3868_26070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3868_26075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D3868_26080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D3868_26090	COG1566	PFAM secretion protein HlyD family protein
D3868_26105	COG2207	Transcriptional regulator
D3868_26120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3868_26130	COG0765	amino acid transport
D3868_26135	COG1126	abc transporter atp-binding protein
D3868_26140	COG1012	belongs to the aldehyde dehydrogenase family
D3868_26150	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D3868_26160	COG2721	sulfolactate sulfo-lyase activity
D3868_26185	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D3868_26205	COG1414	Transcriptional regulator
D3868_26215	COG0601	transmembrane transport
D3868_26220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3868_26225	COG0444	Belongs to the ABC transporter superfamily
D3868_26230	COG4608	Belongs to the ABC transporter superfamily
D3868_26245	COG4302	ethanolamine ammonia-lyase activity
D3868_26250	COG4303	Ethanolamine ammonia lyase large subunit
D3868_26255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_26280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3868_26290	COG0457	Tetratricopeptide repeat
D3868_26290	COG0859	PFAM glycosyl transferase family 9
D3868_26340	COG1749	Flagellar hook protein flgE
D3868_26345	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3868_26360	COG0667	Aldo Keto reductase
D3868_26380	COG4772	TonB-dependent receptor
D3868_26405	COG4251	negative regulation of phosphorylation
D3868_26410	COG0745	RESPONSE REGULATOR receiver
D3868_26415	COG0745	RESPONSE REGULATOR receiver
D3868_26430	COG2080	2 iron, 2 sulfur cluster binding
D3868_26435	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3868_26440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3868_26450	COG2814	Major facilitator Superfamily
D3868_26465	COG0583	DNA-binding transcription factor activity
D3868_26505	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3868_26510	COG1024	Enoyl-CoA hydratase
D3868_26515	COG0022	dehydrogenase e1 component
D3868_26515	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3868_26520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3868_26530	COG0683	leucine binding
D3868_26535	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_26545	COG0410	ABC transporter
D3868_26560	COG4221	oxidoreductase activity
D3868_26565	COG2814	Major facilitator Superfamily
D3868_26580	COG4774	siderophore transport
D3868_26595	COG1802	Transcriptional regulator
D3868_26600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_26605	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3868_26610	COG4948	Mandelate Racemase Muconate Lactonizing
D3868_26615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_26625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3868_26645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3868_26650	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_26655	COG3842	ATPase activity
D3868_26665	COG0277	FAD linked oxidase domain protein
D3868_26675	COG0842	Transport permease protein
D3868_26680	COG1129	ABC transporter
D3868_26680	COG0842	Transport permease protein
D3868_26685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_26690	COG1940	carbohydrate kinase activity
D3868_26700	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3868_26705	COG1879	ABC-type sugar transport system periplasmic component
D3868_26715	COG0673	inositol 2-dehydrogenase activity
D3868_26720	COG2115	Belongs to the xylose isomerase family
D3868_26725	COG1070	Carbohydrate kinase
D3868_26730	COG0583	DNA-binding transcription factor activity
D3868_26740	COG1017	nitric oxide dioxygenase activity
D3868_26740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3868_26745	COG0625	glutathione transferase activity
D3868_26750	COG1802	Transcriptional regulator
D3868_26800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3868_26805	COG3842	ATPase activity
D3868_26810	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_26815	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_26820	COG3938	Belongs to the proline racemase family
D3868_26825	COG1802	Transcriptional regulator
D3868_26830	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D3868_26835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3868_26840	COG0066	3-isopropylmalate dehydratase activity
D3868_26855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_26860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_26870	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3868_26870	COG0515	serine threonine protein kinase
D3868_26895	COG4302	ethanolamine ammonia-lyase activity
D3868_26990	COG1136	(ABC) transporter
D3868_26990	COG0577	efflux transmembrane transporter activity
D3868_27015	COG0523	cobalamin synthesis protein
D3868_27040	COG4977	sequence-specific DNA binding
D3868_27055	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_27070	COG1959	2 iron, 2 sulfur cluster binding
D3868_27110	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_27125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_27135	COG1024	Enoyl-CoA hydratase
D3868_27140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3868_27145	COG0154	amidase activity
D3868_27165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3868_27185	COG1595	DNA-templated transcription, initiation
D3868_27200	COG0697	spore germination
D3868_27215	COG2188	Transcriptional regulator
D3868_27245	COG1121	(ABC) transporter
D3868_27260	COG0577	efflux transmembrane transporter activity
D3868_27260	COG1136	(ABC) transporter
D3868_27275	COG3712	iron ion homeostasis
D3868_27280	COG1595	DNA-templated transcription, initiation
D3868_27305	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D3868_27410	COG1764	response to oxidative stress
D3868_27415	COG1846	Transcriptional regulator
D3868_27420	COG0583	DNA-binding transcription factor activity
D3868_27425	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_27460	COG2828	Protein conserved in bacteria
D3868_27480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3868_27490	COG1396	sequence-specific DNA binding
D3868_27490	COG3800	Transcriptional regulator
D3868_27500	COG0583	DNA-binding transcription factor activity
D3868_27535	COG1783	phage Terminase large subunit
D3868_27560	COG3250	beta-galactosidase activity
D3868_27565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_27590	COG0861	Integral membrane protein TerC family
D3868_27595	COG0251	oxidation-reduction process
D3868_27605	COG0251	oxidation-reduction process
D3868_27610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_27630	COG1177	transmembrane transport
D3868_27635	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_27640	COG3842	ATPase activity
D3868_27655	COG1304	FMN binding
D3868_27660	COG1396	sequence-specific DNA binding
D3868_27670	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_27675	COG3246	L-lysine catabolic process to acetate
D3868_27680	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3868_27685	COG2204	response regulator
D3868_27700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3868_27705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3868_27710	COG1278	Cold shock
D3868_27720	COG0745	RESPONSE REGULATOR receiver
D3868_27720	COG4566	intracellular signal transduction
D3868_27735	COG0411	ABC transporter
D3868_27750	COG0683	leucine binding
D3868_27755	COG2814	Major facilitator Superfamily
D3868_27865	COG3772	lysozyme
D3868_28280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D3868_28285	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3868_28315	COG0633	Ferredoxin
D3868_28320	COG2124	cytochrome p450
D3868_28335	COG0583	DNA-binding transcription factor activity
D3868_28365	COG2271	Major facilitator Superfamily
D3868_28370	COG0583	DNA-binding transcription factor activity
D3868_28400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3868_28440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3868_28455	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D3868_28475	COG4263	nitrous-oxide reductase activity
D3868_28495	COG0714	Associated with various cellular activities
D3868_28500	COG3256	nitric oxide reductase
D3868_28530	COG2223	nitrite transmembrane transporter activity
D3868_28580	COG0489	protein tyrosine kinase activity
D3868_28590	COG4964	Belongs to the GSP D family
D3868_28625	COG1278	Cold shock
D3868_28635	COG0513	Belongs to the DEAD box helicase family
D3868_28660	COG3842	ATPase activity
D3868_28685	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_28705	COG1012	belongs to the aldehyde dehydrogenase family
D3868_28710	COG1024	Enoyl-CoA hydratase
D3868_28715	COG2186	Transcriptional regulator
D3868_28755	COG3436	PFAM IS66 Orf2 family protein
D3868_28780	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_28800	COG2207	Transcriptional regulator
D3868_28830	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_28835	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_28850	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_28865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3868_28880	COG1053	succinate dehydrogenase
D3868_28885	COG1902	pentaerythritol trinitrate reductase activity
D3868_28890	COG0431	NADPH-dependent FMN reductase
D3868_28890	COG1053	succinate dehydrogenase
D3868_28890	COG3976	FMN-binding domain protein
D3868_28910	COG0673	inositol 2-dehydrogenase activity
D3868_28920	COG1053	succinate dehydrogenase
D3868_28930	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_29020	COG1766	The M ring may be actively involved in energy transduction
D3868_29030	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3868_29035	COG1338	Plays a role in the flagellum-specific transport system
D3868_29045	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3868_29065	COG0668	transmembrane transport
D3868_29085	COG1012	belongs to the aldehyde dehydrogenase family
D3868_29220	COG4964	Belongs to the GSP D family
D3868_29240	COG1858	cytochrome C peroxidase
D3868_29270	COG0405	Gamma-glutamyltransferase
D3868_29290	COG2199	diguanylate cyclase activity
D3868_29290	COG2203	Gaf domain
D3868_29305	COG1132	(ABC) transporter
D3868_29375	COG1595	DNA-templated transcription, initiation
D3868_29390	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_29395	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_29415	COG2079	MmgE PrpD family protein
D3868_29420	COG1960	acyl-CoA dehydrogenase activity
D3868_29425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3868_29440	COG0154	amidase activity
D3868_29455	COG2188	Transcriptional regulator
D3868_29510	COG0861	Integral membrane protein TerC family
D3868_29545	COG2721	sulfolactate sulfo-lyase activity
D3868_29550	COG1904	glucuronate isomerase
D3868_29555	COG1803	Methylglyoxal synthase
D3868_29560	COG1802	Transcriptional regulator
D3868_29565	COG0667	Aldo Keto reductase
D3868_29570	COG4774	siderophore transport
D3868_29590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_29600	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_29605	COG1917	Cupin 2, conserved barrel domain protein
D3868_29610	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_29615	COG1802	Transcriptional regulator
D3868_29630	COG0246	Mannitol dehydrogenase
D3868_29635	COG1312	Catalyzes the dehydration of D-mannonate
D3868_29675	COG2133	pyrroloquinoline quinone binding
D3868_29690	COG0583	DNA-binding transcription factor activity
D3868_29700	COG1733	regulation of RNA biosynthetic process
D3868_29705	COG0702	epimerase
D3868_29710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_29715	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_29720	COG1309	transcriptional regulator
D3868_29730	COG2132	Multicopper oxidase
D3868_29735	COG5039	Polysaccharide pyruvyl transferase
D3868_29750	COG0725	ABC transporter, periplasmic molybdate-binding protein
D3868_29755	COG0246	Mannitol dehydrogenase
D3868_29780	COG4214	carbohydrate transport
D3868_29820	COG1879	ABC-type sugar transport system periplasmic component
D3868_29825	COG1129	ABC transporter
D3868_29830	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3868_29835	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3868_29845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D3868_29850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3868_29880	COG0318	PFAM AMP-dependent synthetase and ligase
D3868_29885	COG1278	Cold shock
D3868_29890	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D3868_29900	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3868_29900	COG0574	Belongs to the PEP-utilizing enzyme family
D3868_29910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D3868_29920	COG4106	trans-aconitate 2-methyltransferase activity
D3868_29920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3868_29930	COG0156	8-amino-7-oxononanoate synthase activity
D3868_29945	COG0564	pseudouridine synthase activity
D3868_29955	COG0484	heat shock protein binding
D3868_30000	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_30010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3868_30015	COG4608	Belongs to the ABC transporter superfamily
D3868_30020	COG0444	Belongs to the ABC transporter superfamily
D3868_30030	COG0601	transmembrane transport
D3868_30035	COG0747	negative chemotaxis
D3868_30065	COG2239	Acts as a magnesium transporter
D3868_30070	COG2022	thiamine diphosphate biosynthetic process
D3868_30070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_30080	COG2022	thiamine diphosphate biosynthetic process
D3868_30135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3868_30140	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D3868_30150	COG0191	fructose-bisphosphate aldolase activity
D3868_30175	COG4251	negative regulation of phosphorylation
D3868_30180	COG0784	Response regulator, receiver
D3868_30205	COG4191	Histidine kinase
D3868_30220	COG1045	serine acetyltransferase
D3868_30245	COG3842	ATPase activity
D3868_30250	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3868_30255	COG1178	ABC-type Fe3 transport system permease component
D3868_30265	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3868_30270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3868_30275	COG2233	PERMEase
D3868_30280	COG1254	Belongs to the acylphosphatase family
D3868_30325	COG1131	(ABC) transporter
D3868_30350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3868_30350	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3868_30370	COG0012	GTP binding
D3868_30375	COG5001	Diguanylate cyclase
D3868_30375	COG3300	MHYT domain
D3868_30385	COG0583	DNA-binding transcription factor activity
D3868_30390	COG2814	Major facilitator Superfamily
D3868_30400	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_30405	COG0183	Belongs to the thiolase family
D3868_30410	COG0596	Alpha beta hydrolase
D3868_30410	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3868_30410	COG2226	methyltransferase
D3868_30505	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3868_30530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3868_30545	COG4603	Belongs to the binding-protein-dependent transport system permease family
D3868_30555	COG0402	S-adenosylhomocysteine deaminase activity
D3868_30560	COG0840	transmembrane signaling receptor activity
D3868_30565	COG4191	Histidine kinase
D3868_30595	COG1414	Transcriptional regulator
D3868_30600	COG3383	formate dehydrogenase (NAD+) activity
D3868_30620	COG1597	lipid kinase activity
D3868_30630	COG0628	permease
D3868_30635	COG3416	Protein conserved in bacteria
D3868_30680	COG1802	Transcriptional regulator
D3868_30685	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D3868_30690	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_30700	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3868_30710	COG0148	phosphopyruvate hydratase activity
D3868_30715	COG1882	Formate acetyltransferase
D3868_30720	COG0837	glucose binding
D3868_30720	COG1737	Transcriptional regulator
D3868_30725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_30730	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_30735	COG1309	transcriptional regulator
D3868_30740	COG1309	transcriptional regulator
D3868_30745	COG5002	protein histidine kinase activity
D3868_30750	COG4251	negative regulation of phosphorylation
D3868_30760	COG0469	pyruvate kinase activity
D3868_30765	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3868_30770	COG2116	formate transmembrane transporter activity
D3868_30775	COG0697	spore germination
D3868_30780	COG1802	Transcriptional regulator
D3868_30785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3868_30795	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3868_30800	COG0861	Integral membrane protein TerC family
D3868_30805	COG0840	transmembrane signaling receptor activity
D3868_30830	COG1749	Flagellar hook protein flgE
D3868_30835	COG1256	bacterial-type flagellum assembly
D3868_30845	COG1706	bacterial-type flagellum-dependent cell motility
D3868_30870	COG5001	Diguanylate cyclase
D3868_30870	COG3300	MHYT domain
D3868_30895	COG1028	Short-chain dehydrogenase reductase Sdr
D3868_30905	COG0793	Belongs to the peptidase S41A family
D3868_30910	COG5487	UPF0391 membrane protein
D3868_30920	COG4191	Histidine kinase
D3868_30930	COG0028	Belongs to the TPP enzyme family
D3868_30940	COG1522	sequence-specific DNA binding
D3868_30950	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3868_30955	COG1684	flagellar biosynthetic protein fliR
D3868_30960	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3868_30970	COG4794	Type iii secretion
D3868_30975	COG1677	Flagellar hook-basal body complex protein FliE
D3868_30980	COG1558	bacterial-type flagellum-dependent cell motility
D3868_30985	COG1815	bacterial-type flagellum-dependent cell motility
D3868_30990	COG1157	protein secretion by the type III secretion system
D3868_31005	COG2814	Major facilitator Superfamily
D3868_31025	COG5443	negative regulation of bacterial-type flagellum assembly
D3868_31035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3868_31060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3868_31065	COG1802	Transcriptional regulator
D3868_31080	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3868_31085	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D3868_31090	COG1120	ATPase activity
D3868_31115	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D3868_31125	COG1845	cytochrome c oxidase, subunit III
D3868_31130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3868_31150	COG0567	Dehydrogenase, E1 component
D3868_31155	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3868_31170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3868_31185	COG0277	FAD linked oxidase domain protein
D3868_31190	COG2086	electron transfer activity
D3868_31215	COG0154	amidase activity
D3868_31240	COG0411	ABC transporter
D3868_31250	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_31275	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3868_31295	COG0683	leucine binding
D3868_31300	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_31325	COG3473	Maleate cis-trans isomerase
D3868_31330	COG0596	Alpha beta hydrolase
D3868_31335	COG2309	aminopeptidase activity
D3868_31340	COG1335	isochorismatase
D3868_31350	COG1609	Transcriptional regulator
D3868_31355	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3868_31355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3868_31360	COG1105	Belongs to the carbohydrate kinase PfkB family
D3868_31365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3868_31365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3868_31375	COG3920	Histidine kinase
D3868_31380	COG2197	response regulator
D3868_31410	COG0583	DNA-binding transcription factor activity
D3868_31425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3868_31445	COG0411	ABC transporter
D3868_31455	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3868_31470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3868_31475	COG0251	oxidation-reduction process
D3868_31480	COG1522	sequence-specific DNA binding
D3868_31490	COG1414	Transcriptional regulator
D3868_31495	COG0280	phosphate acetyltransferase
D3868_31515	COG1012	belongs to the aldehyde dehydrogenase family
D3868_31520	COG0045	succinate-CoA ligase (ADP-forming) activity
D3868_31525	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D3868_31530	COG0243	molybdopterin cofactor binding
D3868_31535	COG0437	4 iron, 4 sulfur cluster binding
D3868_31550	COG0028	Belongs to the TPP enzyme family
D3868_31555	COG1475	DNA binding
D3868_31560	COG1192	Involved in chromosome partitioning
D3868_31580	COG0546	phosphoglycolate phosphatase activity
D3868_31595	COG2855	membrane
D3868_31635	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D3868_31640	COG4191	Histidine kinase
D3868_31640	COG0784	Response regulator, receiver
D3868_31665	COG1012	belongs to the aldehyde dehydrogenase family
D3868_31670	COG0028	Belongs to the TPP enzyme family
D3868_31675	COG0583	DNA-binding transcription factor activity
D3868_31680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3868_31685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3868_31700	COG4221	oxidoreductase activity
D3868_31730	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3868_31785	COG1012	belongs to the aldehyde dehydrogenase family
D3868_31785	COG1454	alcohol dehydrogenase
D3868_31860	COG1360	Flagellar Motor Protein
D3868_31865	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3868_31875	COG4786	Flagellar basal body rod
D3868_31880	COG4786	Flagellar basal body rod
D3868_31885	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
D3868_31890	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D3868_31910	COG0243	molybdopterin cofactor binding
D3868_31920	COG3005	denitrification pathway
D3868_31975	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3868_32055	COG0438	transferase activity, transferring glycosyl groups
D3868_32060	COG1215	transferase activity, transferring glycosyl groups
D3868_32070	COG0463	Glycosyl transferase, family 2
D3868_32110	COG0438	transferase activity, transferring glycosyl groups
D3868_32115	COG0438	transferase activity, transferring glycosyl groups
D3868_32115	COG1216	Glycosyl transferase, family 2
D3868_32125	COG0438	transferase activity, transferring glycosyl groups
D3868_32145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3868_32175	COG1088	dTDP-glucose 4,6-dehydratase activity
D3868_32200	COG0528	UMP kinase activity
D3868_32205	COG0528	UMP kinase activity
D3868_32225	COG1051	belongs to the nudix hydrolase family
D3868_32240	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3868_32250	COG1086	Polysaccharide biosynthesis protein
D3868_32265	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3868_32275	COG1475	DNA binding
D3868_32280	COG1192	Involved in chromosome partitioning
D3868_32305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3868_32315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3868_32355	COG1215	transferase activity, transferring glycosyl groups
D3868_32365	COG0297	glycogen (starch) synthase activity
D3868_32425	COG3754	Rhamnan synthesis protein F
D3868_32430	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D3868_32450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3868_32465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3868_32485	COG1088	dTDP-glucose 4,6-dehydratase activity
D3868_32490	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D3868_32495	COG0297	glycogen (starch) synthase activity
D3868_32500	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D3868_32505	COG0579	oxidoreductase
D3868_32510	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3868_32515	COG0500	methyltransferase
D3868_32520	COG0438	transferase activity, transferring glycosyl groups