locus-tag	class	description
D3869_00025	COG0829	nickel cation binding
D3869_00030	COG1819	glycosyl
D3869_00035	COG0831	urea catabolic process
D3869_00040	COG0832	Belongs to the urease beta subunit family
D3869_00045	COG0804	urea catabolic process
D3869_00050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D3869_00055	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D3869_00060	COG0830	nickel cation binding
D3869_00065	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D3869_00070	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
D3869_00080	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3869_00095	COG0640	Transcriptional regulator
D3869_00125	COG1396	sequence-specific DNA binding
D3869_00150	COG1846	Transcriptional regulator
D3869_00180	COG0463	Glycosyl transferase, family 2
D3869_00200	COG1940	carbohydrate kinase activity
D3869_00225	COG0410	ABC transporter
D3869_00250	COG2885	chlorophyll binding
D3869_00250	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3869_00255	COG2197	response regulator
D3869_00260	COG2205	protein histidine kinase activity
D3869_00260	COG2198	Histidine kinase
D3869_00260	COG0784	Response regulator, receiver
D3869_00275	COG0564	pseudouridine synthase activity
D3869_00285	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D3869_00285	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D3869_00330	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_00340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3869_00345	COG1763	Mo-molybdopterin cofactor biosynthetic process
D3869_00355	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D3869_00360	COG0314	molybdopterin synthase activity
D3869_00370	COG1280	lysine exporter protein (LysE YggA)
D3869_00395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3869_00410	COG0776	regulation of translation
D3869_00445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3869_00450	COG0174	glutamine synthetase
D3869_00460	COG3842	ATPase activity
D3869_00465	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_00470	COG1177	transmembrane transport
D3869_00475	COG2957	Belongs to the agmatine deiminase family
D3869_00485	COG0631	protein serine/threonine phosphatase activity
D3869_00500	COG0321	lipoyl(octanoyl) transferase activity
D3869_00500	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D3869_00505	COG0084	hydrolase, TatD family'
D3869_00510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3869_00515	COG0470	DNA polymerase III
D3869_00520	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D3869_00525	COG1686	Belongs to the peptidase S11 family
D3869_00540	COG0840	transmembrane signaling receptor activity
D3869_00545	COG0525	valine-tRNA ligase activity
D3869_00555	COG1538	Outer membrane efflux protein
D3869_00565	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3869_00590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3869_00595	COG0494	nUDIX hydrolase
D3869_00610	COG2897	thiosulfate sulfurtransferase activity
D3869_00630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3869_00635	COG1126	abc transporter atp-binding protein
D3869_00640	COG0765	amino acid transport
D3869_00645	COG4597	amino acid ABC transporter
D3869_00650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_00655	COG0626	cystathionine gamma-synthase activity
D3869_00660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D3869_00705	COG0123	including yeast histone deacetylase and acetoin utilization protein
D3869_00770	COG3608	succinylglutamate desuccinylase aspartoacylase
D3869_00770	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D3869_00775	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3869_00785	COG0737	Belongs to the 5'-nucleotidase family
D3869_00795	COG0686	Belongs to the AlaDH PNT family
D3869_00810	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_00830	COG1846	Transcriptional regulator
D3869_00835	COG1024	Enoyl-CoA hydratase
D3869_00840	COG1597	lipid kinase activity
D3869_00845	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3869_00850	COG0113	porphobilinogen synthase activity
D3869_00855	COG1881	PFAM PEBP family protein
D3869_00865	COG2813	Specifically methylates the guanine in position
D3869_00870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D3869_00875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3869_00880	COG0741	lytic transglycosylase activity
D3869_00890	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D3869_00895	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3869_00910	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D3869_00915	COG0360	Binds together with S18 to 16S ribosomal RNA
D3869_00920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D3869_00930	COG0359	binds to the 23S rRNA
D3869_00935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3869_00940	COG0305	Participates in initiation and elongation during chromosome replication
D3869_00945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3869_00950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3869_00955	COG1127	ABC transporter
D3869_00970	COG0024	Methionine aminopeptidase
D3869_00985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D3869_00990	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_00995	COG1160	GTP binding
D3869_01015	COG2197	response regulator
D3869_01025	COG2197	response regulator
D3869_01050	COG0840	transmembrane signaling receptor activity
D3869_01055	COG0840	transmembrane signaling receptor activity
D3869_01060	COG3706	GGDEF domain
D3869_01060	COG0745	RESPONSE REGULATOR receiver
D3869_01090	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D3869_01095	COG2814	Major facilitator Superfamily
D3869_01110	COG0789	Transcriptional regulator
D3869_01115	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_01135	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3869_01145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3869_01145	COG1116	anion transmembrane transporter activity
D3869_01155	COG0175	sulfate reduction
D3869_01160	COG0175	sulfate reduction
D3869_01165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3869_01165	COG1648	precorrin-2 dehydrogenase activity
D3869_01180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3869_01195	COG4651	solute:proton antiporter activity
D3869_01195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3869_01210	COG4372	Transposase
D3869_01215	COG3436	PFAM IS66 Orf2 family protein
D3869_01240	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3869_01245	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3869_01315	COG0840	transmembrane signaling receptor activity
D3869_01320	COG0784	Response regulator, receiver
D3869_01340	COG3772	lysozyme
D3869_01410	COG4386	tail sheath protein
D3869_01555	COG1396	sequence-specific DNA binding
D3869_01560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D3869_01675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3869_01680	COG0416	fatty acid biosynthetic process
D3869_01685	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D3869_01710	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D3869_01720	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D3869_01725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3869_01730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D3869_01735	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3869_01735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3869_01745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3869_01745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3869_01750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D3869_01755	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3869_01760	COG0698	ribose 5-phosphate isomerase
D3869_01780	COG3685	Protein conserved in bacteria
D3869_01800	COG2153	protein acetylation
D3869_01810	COG1793	dna ligase
D3869_01820	COG2313	pseudouridylate synthase activity
D3869_01830	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3869_01885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_01895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_01905	COG1755	Isoprenylcysteine carboxyl methyltransferase
D3869_01910	COG3424	synthase
D3869_01920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3869_01925	COG1492	cobalamin metabolic process
D3869_01985	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3869_01995	COG1024	Enoyl-CoA hydratase
D3869_02005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3869_02010	COG3411	Ferredoxin
D3869_02030	COG3546	catalase activity
D3869_02035	COG2807	transmembrane transport
D3869_02040	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D3869_02085	COG0546	phosphoglycolate phosphatase activity
D3869_02100	COG3108	Peptidase M15
D3869_02110	COG1773	rubredoxin
D3869_02125	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3869_02130	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D3869_02180	COG2824	Alkylphosphonate utilization operon protein PhnA
D3869_02195	COG0243	molybdopterin cofactor binding
D3869_02205	COG3706	GGDEF domain
D3869_02230	COG1410	methionine synthase
D3869_02230	COG0646	methionine synthase
D3869_02250	COG2853	Lipoprotein
D3869_02265	COG0488	(ABC) transporter
D3869_02270	COG1671	Belongs to the UPF0178 family
D3869_02275	COG2176	DNA-directed DNA polymerase activity
D3869_02275	COG5002	protein histidine kinase activity
D3869_02300	COG1640	4-alpha-glucanotransferase
D3869_02315	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3869_02320	COG0366	Alpha amylase catalytic
D3869_02335	COG1218	3'(2'),5'-bisphosphate nucleotidase
D3869_02340	COG2833	Protein of unknown function (DUF455)
D3869_02355	COG1960	acyl-CoA dehydrogenase activity
D3869_02360	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_02365	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_02370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_02375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3869_02425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_02435	COG1846	Transcriptional regulator
D3869_02440	COG2267	carboxylic ester hydrolase activity
D3869_02455	COG2226	methyltransferase
D3869_02460	COG1201	RNA secondary structure unwinding
D3869_02470	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D3869_02475	COG0415	Belongs to the DNA photolyase family
D3869_02485	COG0735	belongs to the Fur family
D3869_02490	COG0523	cobalamin synthesis protein
D3869_02510	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D3869_02515	COG1234	tRNA 3'-trailer cleavage
D3869_02525	COG0840	transmembrane signaling receptor activity
D3869_02530	COG0840	transmembrane signaling receptor activity
D3869_02545	COG4520	surface antigen
D3869_02575	COG4191	Histidine kinase
D3869_02575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_02590	COG3437	response regulator, receiver
D3869_02590	COG0784	Response regulator, receiver
D3869_02615	COG2076	Multidrug Resistance protein
D3869_02620	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_02625	COG1765	OsmC-like protein
D3869_02635	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D3869_02645	COG0697	spore germination
D3869_02655	COG0367	asparagine synthase
D3869_02670	COG0438	transferase activity, transferring glycosyl groups
D3869_02675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3869_02695	COG2885	chlorophyll binding
D3869_02710	COG0848	biopolymer transport protein
D3869_02720	COG0824	Thioesterase
D3869_02725	COG2255	four-way junction helicase activity
D3869_02740	COG0217	transcriptional regulatory protein
D3869_02745	COG1692	metallophosphoesterase
D3869_02750	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D3869_02795	COG1830	Aldolase
D3869_02800	COG0352	thiamine-phosphate diphosphorylase activity
D3869_02805	COG0730	response to heat
D3869_02810	COG2067	long-chain fatty acid transport protein
D3869_02815	COG0604	alcohol dehydrogenase
D3869_02820	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D3869_02825	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D3869_02830	COG0483	inositol monophosphate 1-phosphatase activity
D3869_02850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3869_02855	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3869_02860	COG0509	glycine decarboxylation via glycine cleavage system
D3869_02865	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D3869_02885	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D3869_02895	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D3869_02900	COG0328	RNA-DNA hybrid ribonuclease activity
D3869_02905	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_02910	COG0678	peroxiredoxin activity
D3869_02920	COG1678	Uncharacterized ACR, COG1678
D3869_02930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3869_02935	COG0612	Peptidase, M16
D3869_02945	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3869_02955	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D3869_02960	COG3346	SURF1 family
D3869_02980	COG0109	protoheme IX farnesyltransferase activity
D3869_02985	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3869_02990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3869_03000	COG0312	modulator of DNA gyrase
D3869_03010	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3869_03020	COG5487	UPF0391 membrane protein
D3869_03030	COG0741	lytic transglycosylase activity
D3869_03060	COG0564	pseudouridine synthase activity
D3869_03065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3869_03080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3869_03085	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D3869_03095	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3869_03110	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3869_03115	COG1295	ribonuclease BN
D3869_03120	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3869_03130	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D3869_03140	COG0745	RESPONSE REGULATOR receiver
D3869_03150	COG0616	signal peptide processing
D3869_03160	COG0784	Response regulator, receiver
D3869_03160	COG5002	protein histidine kinase activity
D3869_03160	COG2198	Histidine kinase
D3869_03170	COG0390	transport system, permease component
D3869_03175	COG1116	anion transmembrane transporter activity
D3869_03185	COG0628	permease
D3869_03190	COG2205	protein histidine kinase activity
D3869_03200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3869_03210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3869_03215	COG0251	oxidation-reduction process
D3869_03225	COG0551	DNA topoisomerase type I activity
D3869_03225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3869_03260	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3869_03270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3869_03305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3869_03320	COG0505	Belongs to the CarA family
D3869_03330	COG1403	HNH endonuclease
D3869_03340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3869_03345	COG1393	Belongs to the ArsC family
D3869_03350	COG2890	protein-(glutamine-N5) methyltransferase activity
D3869_03355	COG0456	acetyltransferase
D3869_03355	COG1214	PFAM Peptidase M22, glycoprotease
D3869_03395	COG0538	isocitrate dehydrogenase activity
D3869_03405	COG3932	Exopolysaccharide synthesis, ExoD
D3869_03425	COG0473	3-isopropylmalate dehydrogenase activity
D3869_03455	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3869_03475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3869_03490	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3869_03515	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3869_03520	COG1684	flagellar biosynthetic protein fliR
D3869_03525	COG1987	bacterial-type flagellum assembly
D3869_03530	COG1677	Flagellar hook-basal body complex protein FliE
D3869_03535	COG1558	bacterial-type flagellum-dependent cell motility
D3869_03540	COG1815	bacterial-type flagellum-dependent cell motility
D3869_03545	COG2257	FlhB HrpN YscU SpaS Family
D3869_03560	COG1338	Plays a role in the flagellum-specific transport system
D3869_03575	COG1360	Flagellar Motor Protein
D3869_03615	COG4786	Flagellar basal body rod
D3869_03620	COG4786	Flagellar basal body rod
D3869_03630	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D3869_03635	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D3869_03670	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3869_03695	COG0500	methyltransferase
D3869_03705	COG1132	(ABC) transporter
D3869_03710	COG0254	rRNA binding
D3869_03720	COG0071	Belongs to the small heat shock protein (HSP20) family
D3869_03740	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3869_03755	COG2186	Transcriptional regulator
D3869_03760	COG0563	adenylate kinase activity
D3869_03765	COG0201	protein transport
D3869_03770	COG0200	Binds to the 23S rRNA
D3869_03775	COG1841	ribosomal large subunit assembly
D3869_03790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D3869_03795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D3869_03800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D3869_03810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D3869_03820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D3869_03825	COG0255	Belongs to the universal ribosomal protein uL29 family
D3869_03830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D3869_03835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D3869_03840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D3869_03845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D3869_03850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D3869_03855	COG0089	rRNA binding
D3869_03860	COG0088	Forms part of the polypeptide exit tunnel
D3869_03870	COG0051	transcription antitermination factor activity, RNA binding
D3869_03885	COG0049	tRNA binding
D3869_03900	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D3869_03905	COG0085	RNA polymerase activity
D3869_03910	COG0222	ribosome binding
D3869_03915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D3869_03920	COG0081	regulation of translation
D3869_03925	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D3869_04010	COG0410	ABC transporter
D3869_04025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D3869_04035	COG1940	carbohydrate kinase activity
D3869_04045	COG0840	transmembrane signaling receptor activity
D3869_04045	COG2972	Histidine kinase
D3869_04050	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3869_04055	COG0410	ABC transporter
D3869_04060	COG0411	ABC transporter
D3869_04070	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_04090	COG0673	inositol 2-dehydrogenase activity
D3869_04100	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3869_04110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_04115	COG1309	transcriptional regulator
D3869_04125	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3869_04145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3869_04185	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3869_04190	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3869_04195	COG1530	ribonuclease E activity
D3869_04235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D3869_04240	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D3869_04250	COG2264	protein methyltransferase activity
D3869_04260	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D3869_04275	COG0312	modulator of DNA gyrase
D3869_04295	COG1597	lipid kinase activity
D3869_04315	COG1519	Transferase
D3869_04320	COG1663	tetraacyldisaccharide 4'-kinase activity
D3869_04330	COG1280	lysine exporter protein (LysE YggA)
D3869_04360	COG3719	Belongs to the RNase T2 family
D3869_04365	COG0439	Biotin carboxylase
D3869_04370	COG0511	ligase activity, forming carbon-carbon bonds
D3869_04405	COG0840	transmembrane signaling receptor activity
D3869_04425	COG3108	Peptidase M15
D3869_04430	COG3409	Peptidoglycan-binding domain 1 protein
D3869_04430	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3869_04460	COG2205	protein histidine kinase activity
D3869_04470	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3869_04505	COG1073	alpha beta
D3869_04510	COG1380	Effector of murein hydrolase LrgA
D3869_04515	COG1346	cytolysis
D3869_04520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3869_04530	COG0751	glycine-tRNA ligase activity
D3869_04535	COG0752	glycyl-tRNA synthetase alpha subunit
D3869_04555	COG2890	protein-(glutamine-N5) methyltransferase activity
D3869_04565	COG0142	geranyltranstransferase activity
D3869_04590	COG0784	Response regulator, receiver
D3869_04590	COG4191	Histidine kinase
D3869_04605	COG2084	Dehydrogenase
D3869_04610	COG0277	FAD linked oxidase domain protein
D3869_04625	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D3869_04635	COG0697	spore germination
D3869_04650	COG2001	Belongs to the MraZ family
D3869_04670	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3869_04680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3869_04695	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D3869_04705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3869_04710	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D3869_04715	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3869_04720	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D3869_04725	COG0849	cell division
D3869_04730	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D3869_04745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D3869_04770	COG0497	DNA recombination
D3869_04775	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3869_04790	COG0745	RESPONSE REGULATOR receiver
D3869_04795	COG0006	proline dipeptidase activity
D3869_04795	COG0006	proline dipeptidase activity
D3869_04805	COG2264	protein methyltransferase activity
D3869_04820	COG0210	DNA helicase
D3869_04825	COG2197	response regulator
D3869_04830	COG2197	response regulator
D3869_04860	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D3869_04870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3869_04880	COG2205	protein histidine kinase activity
D3869_04890	COG2205	protein histidine kinase activity
D3869_04890	COG2202	Pas domain
D3869_04930	COG2988	succinylglutamate desuccinylase activity
D3869_04935	COG3180	Ammonia monooxygenase
D3869_04950	COG0628	permease
D3869_04955	COG0330	HflC and HflK could
D3869_04980	COG0745	RESPONSE REGULATOR receiver
D3869_05000	COG1116	anion transmembrane transporter activity
D3869_05005	COG1643	Atp-dependent helicase
D3869_05020	COG2719	SpoVR family
D3869_05025	COG2718	Belongs to the UPF0229 family
D3869_05030	COG2766	serine protein kinase
D3869_05035	COG0745	RESPONSE REGULATOR receiver
D3869_05045	COG0784	Response regulator, receiver
D3869_05045	COG2205	protein histidine kinase activity
D3869_05050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3869_05065	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D3869_05105	COG1116	anion transmembrane transporter activity
D3869_05155	COG1131	(ABC) transporter
D3869_05170	COG0723	plastoquinol--plastocyanin reductase activity
D3869_05185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3869_05195	COG0463	Glycosyl transferase, family 2
D3869_05200	COG0840	transmembrane signaling receptor activity
D3869_05225	COG0602	queuosine metabolic process
D3869_05230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D3869_05270	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D3869_05275	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D3869_05280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D3869_05290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3869_05300	COG2010	Cytochrome c
D3869_05310	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D3869_05315	COG0799	negative regulation of ribosome biogenesis
D3869_05320	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D3869_05325	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D3869_05335	COG0793	Belongs to the peptidase S41A family
D3869_05345	COG1051	belongs to the nudix hydrolase family
D3869_05365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D3869_05375	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3869_05395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3869_05405	COG4974	Belongs to the 'phage' integrase family
D3869_05410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3869_05420	COG0596	Alpha beta hydrolase
D3869_05440	COG4191	Histidine kinase
D3869_05450	COG4106	trans-aconitate 2-methyltransferase activity
D3869_05480	COG2226	methyltransferase
D3869_05485	COG0126	phosphoglycerate kinase activity
D3869_05495	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D3869_05510	COG3474	cytochrome
D3869_05515	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3869_05540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3869_05545	COG4166	transmembrane transport
D3869_05555	COG4166	transmembrane transport
D3869_05560	COG4174	ABC transporter (Permease)
D3869_05565	COG4239	(ABC) transporter, permease
D3869_05570	COG4172	Belongs to the ABC transporter superfamily
D3869_05590	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3869_05595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3869_05600	COG0625	glutathione transferase activity
D3869_05620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3869_05625	COG0587	DNA-directed DNA polymerase activity
D3869_05640	COG4544	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
D3869_05660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3869_05665	COG0625	glutathione transferase activity
D3869_05675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_05680	COG0601	transmembrane transport
D3869_05690	COG1024	Enoyl-CoA hydratase
D3869_05705	COG0583	DNA-binding transcription factor activity
D3869_05730	COG5001	Diguanylate cyclase
D3869_05735	COG0625	glutathione transferase activity
D3869_05740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3869_05750	COG0156	8-amino-7-oxononanoate synthase activity
D3869_05765	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_05780	COG1322	Protein conserved in bacteria
D3869_05785	COG1278	Cold shock
D3869_05795	COG0242	peptide deformylase activity
D3869_05800	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3869_05805	COG0101	tRNA pseudouridine synthase activity
D3869_05810	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_05825	COG2378	regulation of single-species biofilm formation
D3869_05830	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3869_05845	COG0335	large ribosomal subunit rRNA binding
D3869_05855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D3869_05860	COG0228	four-way junction DNA binding
D3869_05865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D3869_05905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3869_05925	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D3869_05940	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3869_05950	COG1131	(ABC) transporter
D3869_05960	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D3869_05965	COG0697	spore germination
D3869_05985	COG0489	protein tyrosine kinase activity
D3869_05985	COG3206	protein involved in exopolysaccharide biosynthesis
D3869_05995	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D3869_06005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_06020	COG0438	transferase activity, transferring glycosyl groups
D3869_06060	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D3869_06070	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D3869_06075	COG0706	membrane insertase activity
D3869_06080	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D3869_06095	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3869_06105	COG0598	Magnesium transport protein CorA
D3869_06120	COG0825	malonyl-CoA metabolic process
D3869_06135	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3869_06140	COG4974	Belongs to the 'phage' integrase family
D3869_06160	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D3869_06165	COG0517	IMP dehydrogenase activity
D3869_06180	COG0271	Belongs to the BolA IbaG family
D3869_06210	COG1840	ABC-type Fe3 transport system, periplasmic component
D3869_06215	COG1741	Belongs to the pirin family
D3869_06220	COG1178	ABC-type Fe3 transport system permease component
D3869_06225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3869_06230	COG3706	GGDEF domain
D3869_06230	COG0745	RESPONSE REGULATOR receiver
D3869_06235	COG0135	phosphoribosylanthranilate isomerase activity
D3869_06260	COG2423	ornithine cyclodeaminase activity
D3869_06270	COG0776	regulation of translation
D3869_06280	COG0539	negative regulation of cytoplasmic translation
D3869_06295	COG0405	Gamma-glutamyltransferase
D3869_06315	COG1741	Belongs to the pirin family
D3869_06320	COG0303	'Molybdopterin
D3869_06325	COG0303	'Molybdopterin
D3869_06330	COG3706	GGDEF domain
D3869_06330	COG0745	RESPONSE REGULATOR receiver
D3869_06345	COG0463	Glycosyl transferase, family 2
D3869_06355	COG0071	Belongs to the small heat shock protein (HSP20) family
D3869_06385	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D3869_06415	COG1215	transferase activity, transferring glycosyl groups
D3869_06435	COG1012	belongs to the aldehyde dehydrogenase family
D3869_06470	COG3162	membrane
D3869_06485	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3869_06490	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3869_06495	COG1040	competence protein
D3869_06500	COG1987	bacterial-type flagellum assembly
D3869_06525	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D3869_06530	COG0513	Belongs to the DEAD box helicase family
D3869_06535	COG1970	mechanosensitive ion channel activity
D3869_06540	COG0653	protein targeting
D3869_06545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3869_06555	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D3869_06565	COG0494	nUDIX hydrolase
D3869_06570	COG0514	ATP-dependent DNA helicase (RecQ)
D3869_06600	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3869_06605	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_06635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3869_06640	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3869_06645	COG0412	Dienelactone hydrolase
D3869_06650	COG0033	Phosphoglucomutase
D3869_06655	COG1278	Cold shock
D3869_06685	COG0302	gtp cyclohydrolase
D3869_06690	COG2205	protein histidine kinase activity
D3869_06690	COG2202	Pas domain
D3869_06720	COG0285	dihydrofolate synthase activity
D3869_06725	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3869_06735	COG0133	tryptophan synthase activity
D3869_06740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_06745	COG0784	Response regulator, receiver
D3869_06745	COG5002	protein histidine kinase activity
D3869_06745	COG2205	protein histidine kinase activity
D3869_06750	COG2205	protein histidine kinase activity
D3869_06755	COG1252	NADH dehydrogenase
D3869_06765	COG0745	RESPONSE REGULATOR receiver
D3869_06785	COG0802	atpase or kinase
D3869_06795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D3869_06800	COG2887	Belongs to the helicase family. UvrD subfamily
D3869_06805	COG1074	ATP-dependent DNA helicase activity
D3869_06815	COG0583	DNA-binding transcription factor activity
D3869_06830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3869_06835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D3869_06840	COG1573	uracil-dna glycosylase
D3869_06860	COG0598	Magnesium transport protein CorA
D3869_06865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D3869_06870	COG1872	DUF167
D3869_06885	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3869_06890	COG4133	protoheme IX ABC transporter activity
D3869_06895	COG2985	domain, Protein
D3869_06900	COG2985	domain, Protein
D3869_06950	COG0671	phosphoesterase, PA-phosphatase related
D3869_06960	COG0784	Response regulator, receiver
D3869_06960	COG3437	response regulator, receiver
D3869_06975	COG1983	PspC domain protein
D3869_06985	COG1842	Phage shock protein A
D3869_06990	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D3869_07000	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3869_07015	COG3005	denitrification pathway
D3869_07020	COG1858	cytochrome C peroxidase
D3869_07025	COG0753	catalase activity
D3869_07030	COG0459	protein refolding
D3869_07035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3869_07040	COG5425	PFAM Usg family protein
D3869_07045	COG3772	lysozyme
D3869_07050	COG0493	'glutamate synthase
D3869_07050	COG0543	2 iron, 2 sulfur cluster binding
D3869_07055	COG1612	heme a metabolic process
D3869_07090	COG0668	transmembrane transport
D3869_07100	COG4181	ATPase activity
D3869_07115	COG0667	Aldo Keto reductase
D3869_07120	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D3869_07125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3869_07130	COG0347	Belongs to the P(II) protein family
D3869_07155	COG0606	chelatase, subunit chli
D3869_07165	COG0747	negative chemotaxis
D3869_07180	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D3869_07200	COG3685	Protein conserved in bacteria
D3869_07215	COG2304	oxidoreductase activity
D3869_07225	COG1013	pyruvate-flavodoxin oxidoreductase activity
D3869_07230	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D3869_07230	COG0674	pyruvate-flavodoxin oxidoreductase activity
D3869_07235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3869_07240	COG2205	protein histidine kinase activity
D3869_07240	COG2202	Pas domain
D3869_07245	COG0693	protein deglycase activity
D3869_07250	COG2224	Isocitrate lyase
D3869_07255	COG1396	sequence-specific DNA binding
D3869_07255	COG3800	Transcriptional regulator
D3869_07270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3869_07275	COG3437	response regulator, receiver
D3869_07275	COG0784	Response regulator, receiver
D3869_07280	COG3706	GGDEF domain
D3869_07285	COG0484	heat shock protein binding
D3869_07290	COG0443	Heat shock 70 kDa protein
D3869_07310	COG0745	RESPONSE REGULATOR receiver
D3869_07320	COG1420	regulation of RNA biosynthetic process
D3869_07325	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D3869_07330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D3869_07335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3869_07340	COG0840	transmembrane signaling receptor activity
D3869_07340	COG0840	transmembrane signaling receptor activity
D3869_07370	COG0792	nuclease activity
D3869_07375	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D3869_07395	COG1366	Belongs to the anti-sigma-factor antagonist family
D3869_07405	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3869_07445	COG2205	protein histidine kinase activity
D3869_07445	COG0784	Response regulator, receiver
D3869_07455	COG0180	Tryptophanyl-tRNA synthetase
D3869_07465	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D3869_07475	COG3012	SEC-C Motif Domain Protein
D3869_07490	COG0110	maltose O-acetyltransferase activity
D3869_07495	COG1309	transcriptional regulator
D3869_07500	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_07515	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D3869_07520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D3869_07525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3869_07550	COG0438	transferase activity, transferring glycosyl groups
D3869_07555	COG3706	GGDEF domain
D3869_07555	COG0745	RESPONSE REGULATOR receiver
D3869_07570	COG1132	(ABC) transporter
D3869_07575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_07575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3869_07605	COG0601	transmembrane transport
D3869_07610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_07620	COG1234	tRNA 3'-trailer cleavage
D3869_07640	COG0745	RESPONSE REGULATOR receiver
D3869_07710	COG1475	DNA binding
D3869_07715	COG1192	Involved in chromosome partitioning
D3869_07720	COG0357	Ribosomal RNA small subunit methyltransferase G
D3869_07725	COG0445	tRNA wobble uridine modification
D3869_07735	COG3411	Ferredoxin
D3869_07745	COG1331	Highly conserved protein containing a thioredoxin domain
D3869_07750	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3869_07760	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3869_07765	COG0237	dephospho-CoA kinase activity
D3869_07800	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D3869_07805	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D3869_07815	COG4395	Tim44
D3869_07820	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D3869_07875	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D3869_07885	COG0488	(ABC) transporter
D3869_07890	COG2205	protein histidine kinase activity
D3869_07905	COG1556	Lactate utilization protein
D3869_07910	COG1139	Iron-sulfur cluster binding protein
D3869_07915	COG0247	lactate metabolic process
D3869_07920	COG0840	transmembrane signaling receptor activity
D3869_07935	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3869_07940	COG1121	(ABC) transporter
D3869_07950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D3869_07955	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3869_07965	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3869_07980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3869_07985	COG0730	response to heat
D3869_08010	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D3869_08020	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D3869_08055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3869_08070	COG1253	flavin adenine dinucleotide binding
D3869_08075	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D3869_08080	COG1396	sequence-specific DNA binding
D3869_08085	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D3869_08090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D3869_08095	COG2329	Antibiotic biosynthesis monooxygenase
D3869_08100	COG0779	Required for maturation of 30S ribosomal subunits
D3869_08125	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D3869_08135	COG1185	polyribonucleotide nucleotidyltransferase activity
D3869_08140	COG2321	neutral zinc metallopeptidase
D3869_08150	COG1509	lysine 2,3-aminomutase activity
D3869_08155	COG0584	glycerophosphoryl diester phosphodiesterase
D3869_08170	COG1592	Rubrerythrin
D3869_08200	COG0039	L-malate dehydrogenase activity
D3869_08205	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D3869_08210	COG4166	transmembrane transport
D3869_08220	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3869_08225	COG2226	methyltransferase
D3869_08230	COG0859	PFAM glycosyl transferase family 9
D3869_08230	COG0457	Tetratricopeptide repeat
D3869_08235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D3869_08245	COG1024	Enoyl-CoA hydratase
D3869_08250	COG0268	Binds directly to 16S ribosomal RNA
D3869_08255	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3869_08260	COG3706	GGDEF domain
D3869_08265	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3869_08270	COG3842	ATPase activity
D3869_08290	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_08295	COG1177	transmembrane transport
D3869_08310	COG2132	Multicopper oxidase
D3869_08320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D3869_08360	COG2217	Heavy metal translocating P-type atpase
D3869_08370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_08375	COG0281	malic enzyme
D3869_08375	COG0280	phosphate acetyltransferase
D3869_08380	COG5002	protein histidine kinase activity
D3869_08385	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3869_08390	COG0573	inorganic phosphate transmembrane transporter activity
D3869_08400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3869_08405	COG0704	Plays a role in the regulation of phosphate uptake
D3869_08410	COG0745	RESPONSE REGULATOR receiver
D3869_08425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D3869_08435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3869_08445	COG0756	dUTP diphosphatase activity
D3869_08450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D3869_08455	COG2204	response regulator
D3869_08460	COG1278	Cold shock
D3869_08470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3869_08475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3869_08475	COG1321	iron dependent repressor
D3869_08480	COG1121	(ABC) transporter
D3869_08485	COG0803	Belongs to the bacterial solute-binding protein 9 family
D3869_08520	COG2205	protein histidine kinase activity
D3869_08520	COG2202	Pas domain
D3869_08545	COG1253	flavin adenine dinucleotide binding
D3869_08560	COG0477	Major facilitator Superfamily
D3869_08565	COG0583	DNA-binding transcription factor activity
D3869_08585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3869_08595	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3869_08600	COG4783	chaperone-mediated protein folding
D3869_08615	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D3869_08620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D3869_08625	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D3869_08640	COG3437	response regulator, receiver
D3869_08640	COG0784	Response regulator, receiver
D3869_08650	COG0583	DNA-binding transcription factor activity
D3869_08660	COG0481	GTPase activity
D3869_08670	COG0297	glycogen (starch) synthase activity
D3869_08675	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3869_08680	COG0004	ammonium transporteR
D3869_08715	COG3806	Anti-sigma factor
D3869_08720	COG1595	DNA-templated transcription, initiation
D3869_08730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D3869_08745	COG0137	argininosuccinate synthase activity
D3869_08760	COG2897	thiosulfate sulfurtransferase activity
D3869_08765	COG3339	Conserved Protein
D3869_08770	COG0697	spore germination
D3869_08775	COG4235	cytochrome complex assembly
D3869_08780	COG3088	subunit of a heme lyase
D3869_08785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3869_08790	COG1138	Cytochrome C-type biogenesis protein
D3869_08795	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D3869_08805	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3869_08840	COG0747	negative chemotaxis
D3869_08845	COG0601	transmembrane transport
D3869_08875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D3869_08885	COG0302	gtp cyclohydrolase
D3869_08890	COG2967	ApaG domain
D3869_08970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_08985	COG5002	protein histidine kinase activity
D3869_09000	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3869_09005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_09005	COG4191	Histidine kinase
D3869_09015	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3869_09025	COG2885	chlorophyll binding
D3869_09055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3869_09085	COG0181	hydroxymethylbilane synthase activity
D3869_09105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D3869_09110	COG2350	Protein conserved in bacteria
D3869_09125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3869_09145	COG0501	Belongs to the peptidase M48B family
D3869_09160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3869_09160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D3869_09170	COG0138	bifunctional purine biosynthesis protein purh
D3869_09195	COG2264	protein methyltransferase activity
D3869_09205	COG2902	Dehydrogenase
D3869_09210	COG2770	Histidine kinase
D3869_09210	COG3437	response regulator, receiver
D3869_09220	COG0840	transmembrane signaling receptor activity
D3869_09235	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3869_09250	COG3118	belongs to the thioredoxin family
D3869_09255	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3869_09260	COG2835	tetraacyldisaccharide 4'-kinase activity
D3869_09295	COG1285	pathogenesis
D3869_09300	COG2814	Major facilitator Superfamily
D3869_09335	COG0395	ABC-type sugar transport system, permease component
D3869_09340	COG3842	ATPase activity
D3869_09345	COG0625	glutathione transferase activity
D3869_09360	COG0513	Belongs to the DEAD box helicase family
D3869_09385	COG4191	Histidine kinase
D3869_09400	COG0745	RESPONSE REGULATOR receiver
D3869_09420	COG0745	RESPONSE REGULATOR receiver
D3869_09425	COG0745	RESPONSE REGULATOR receiver
D3869_09425	COG3706	GGDEF domain
D3869_09435	COG1366	Belongs to the anti-sigma-factor antagonist family
D3869_09440	COG0840	transmembrane signaling receptor activity
D3869_09445	COG2201	protein-glutamate methylesterase activity
D3869_09450	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D3869_09460	COG0840	transmembrane signaling receptor activity
D3869_09465	COG0835	chemotaxis
D3869_09470	COG0643	Histidine kinase
D3869_09470	COG2198	Histidine kinase
D3869_09485	COG5002	protein histidine kinase activity
D3869_09495	COG5002	protein histidine kinase activity
D3869_09495	COG2176	DNA-directed DNA polymerase activity
D3869_09500	COG0745	RESPONSE REGULATOR receiver
D3869_09525	COG2917	probably involved in intracellular septation
D3869_09535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D3869_09540	COG0552	protein localization to endoplasmic reticulum
D3869_09545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3869_09550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D3869_09600	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D3869_09615	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D3869_09620	COG3706	GGDEF domain
D3869_09625	COG2205	protein histidine kinase activity
D3869_09630	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3869_09645	COG0045	succinate-CoA ligase (ADP-forming) activity
D3869_09650	COG0039	L-malate dehydrogenase activity
D3869_09665	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
D3869_09670	COG2076	Multidrug Resistance protein
D3869_09675	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3869_09680	COG1199	ATP-dependent helicase activity
D3869_09680	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3869_09685	COG0840	transmembrane signaling receptor activity
D3869_09695	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D3869_09700	COG0840	transmembrane signaling receptor activity
D3869_09700	COG2972	Histidine kinase
D3869_09715	COG2084	Dehydrogenase
D3869_09725	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3869_09760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3869_09875	COG0167	dihydroorotate dehydrogenase activity
D3869_09885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D3869_09890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3869_09895	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3869_09980	COG4695	Portal protein
D3869_10025	COG0582	viral genome integration into host DNA
D3869_10030	COG1902	pentaerythritol trinitrate reductase activity
D3869_10065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3869_10075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3869_10080	COG1116	anion transmembrane transporter activity
D3869_10085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_10090	COG0583	DNA-binding transcription factor activity
D3869_10135	COG1846	Transcriptional regulator
D3869_10190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3869_10195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3869_10205	COG0783	Belongs to the Dps family
D3869_10215	COG0492	ferredoxin-NADP+ reductase activity
D3869_10230	COG3660	Nucleoside-diphosphate-sugar epimerase
D3869_10235	COG1522	sequence-specific DNA binding
D3869_10245	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3869_10250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3869_10275	COG1674	ftsk spoiiie
D3869_10285	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3869_10295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3869_10300	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_10305	COG1238	metal cluster binding
D3869_10325	COG1012	belongs to the aldehyde dehydrogenase family
D3869_10350	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D3869_10360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_10360	COG2205	protein histidine kinase activity
D3869_10370	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D3869_10380	COG5002	protein histidine kinase activity
D3869_10390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3869_10400	COG3279	Response regulator of the LytR AlgR family
D3869_10415	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D3869_10430	COG1902	pentaerythritol trinitrate reductase activity
D3869_10440	COG2962	Rard protein
D3869_10450	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D3869_10460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3869_10465	COG0047	phosphoribosylformylglycinamidine synthase activity
D3869_10470	COG0583	DNA-binding transcription factor activity
D3869_10480	COG2258	MOSC domain
D3869_10490	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3869_10495	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3869_10510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D3869_10530	COG0024	Methionine aminopeptidase
D3869_10535	COG1489	DNA binding
D3869_10540	COG1546	Belongs to the CinA family
D3869_10540	COG1058	Belongs to the CinA family
D3869_10585	COG0124	histidyl-tRNA synthetase
D3869_10590	COG0418	dihydroorotase activity
D3869_10600	COG1570	exodeoxyribonuclease VII activity
D3869_10620	COG4783	chaperone-mediated protein folding
D3869_10625	COG0590	tRNA wobble adenosine to inosine editing
D3869_10630	COG3360	Dodecin
D3869_10635	COG1187	pseudouridine synthase activity
D3869_10640	COG0742	ribosomal rna small subunit methyltransferase
D3869_10655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3869_10720	COG1749	Flagellar hook protein flgE
D3869_10725	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3869_10735	COG0667	Aldo Keto reductase
D3869_10745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_10750	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D3869_10755	COG1301	dicarboxylic acid transport
D3869_10760	COG2828	Protein conserved in bacteria
D3869_10765	COG0583	DNA-binding transcription factor activity
D3869_10775	COG2188	Transcriptional regulator
D3869_10780	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3869_10805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3869_10825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3869_10835	COG1116	anion transmembrane transporter activity
D3869_10910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D3869_10925	COG0166	Belongs to the GPI family
D3869_10935	COG0612	Peptidase, M16
D3869_10940	COG0612	Peptidase, M16
D3869_10950	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3869_10955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D3869_10960	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3869_10965	COG0196	riboflavin kinase activity
D3869_10970	COG2030	dehydratase
D3869_10980	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D3869_11005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3869_11010	COG2703	oxygen carrier activity
D3869_11035	COG0590	tRNA wobble adenosine to inosine editing
D3869_11060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D3869_11085	COG1686	Belongs to the peptidase S11 family
D3869_11100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3869_11105	COG0746	molybdenum cofactor guanylyltransferase activity
D3869_11130	COG0243	molybdopterin cofactor binding
D3869_11130	COG3383	formate dehydrogenase (NAD+) activity
D3869_11135	COG0437	4 iron, 4 sulfur cluster binding
D3869_11160	COG0235	Class ii aldolase
D3869_11170	COG3384	dioxygenase
D3869_11180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3869_11185	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3869_11190	COG0356	it plays a direct role in the translocation of protons across the membrane
D3869_11200	COG1999	signal sequence binding
D3869_11210	COG0840	transmembrane signaling receptor activity
D3869_11215	COG1702	phosphate starvation-inducible protein PhoH
D3869_11220	COG0850	regulation of cytokinetic process
D3869_11225	COG2894	cell division
D3869_11230	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D3869_11245	COG0840	transmembrane signaling receptor activity
D3869_11250	COG0840	transmembrane signaling receptor activity
D3869_11255	COG4948	Mandelate Racemase Muconate Lactonizing
D3869_11265	COG1104	cysteine desulfurase activity
D3869_11275	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3869_11290	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D3869_11305	COG0840	transmembrane signaling receptor activity
D3869_11310	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3869_11315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3869_11320	COG1278	Cold shock
D3869_11330	COG5002	protein histidine kinase activity
D3869_11330	COG2205	protein histidine kinase activity
D3869_11330	COG0784	Response regulator, receiver
D3869_11350	COG0644	oxidoreductase
D3869_11355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D3869_11415	COG5420	small protein containing a coiled-coil domain
D3869_11430	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D3869_11435	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D3869_11450	COG1959	2 iron, 2 sulfur cluster binding
D3869_11490	COG0121	glutamine amidotransferase
D3869_11505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3869_11530	COG5554	nitrogen fixation
D3869_11545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3869_11570	COG1309	transcriptional regulator
D3869_11580	COG1131	(ABC) transporter
D3869_11585	COG0842	Transport permease protein
D3869_11590	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D3869_11600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D3869_11610	COG0277	FAD linked oxidase domain protein
D3869_11615	COG0277	FAD linked oxidase domain protein
D3869_11620	COG0247	lactate metabolic process
D3869_11640	COG1960	acyl-CoA dehydrogenase activity
D3869_11655	COG0277	FAD linked oxidase domain protein
D3869_11660	COG0009	L-threonylcarbamoyladenylate synthase
D3869_11665	COG1192	Involved in chromosome partitioning
D3869_11670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3869_11675	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D3869_11695	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D3869_11700	COG2945	thiolester hydrolase activity
D3869_11705	COG1045	serine acetyltransferase
D3869_11720	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D3869_11725	COG0633	Ferredoxin
D3869_11730	COG0482	sulfurtransferase activity
D3869_11740	COG0583	DNA-binding transcription factor activity
D3869_11755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_11780	COG4221	oxidoreductase activity
D3869_11795	COG2010	Cytochrome c
D3869_11795	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3869_11800	COG2080	2 iron, 2 sulfur cluster binding
D3869_11805	COG2010	Cytochrome c
D3869_11805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3869_11810	COG5002	protein histidine kinase activity
D3869_11820	COG0745	RESPONSE REGULATOR receiver
D3869_11845	COG0432	Pfam Uncharacterised protein family UPF0047
D3869_11855	COG2951	lytic endotransglycosylase activity
D3869_11875	COG1454	alcohol dehydrogenase
D3869_11910	COG0456	acetyltransferase
D3869_11925	COG0114	fumarate hydratase activity
D3869_11940	COG5001	Diguanylate cyclase
D3869_11945	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D3869_11960	COG0205	6-phosphofructokinase activity
D3869_11990	COG0288	reversible hydration of carbon dioxide
D3869_12050	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_12060	COG0840	transmembrane signaling receptor activity
D3869_12080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D3869_12085	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3869_12090	COG0343	queuine tRNA-ribosyltransferase activity
D3869_12095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D3869_12100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3869_12140	COG2897	thiosulfate sulfurtransferase activity
D3869_12205	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3869_12210	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3869_12215	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D3869_12225	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D3869_12230	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3869_12235	COG0242	peptide deformylase activity
D3869_12245	COG3070	regulator of competence-specific genes
D3869_12260	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D3869_12285	COG4120	Belongs to the binding-protein-dependent transport system permease family
D3869_12290	COG0410	ABC transporter
D3869_12300	COG0489	protein tyrosine kinase activity
D3869_12305	COG0330	HflC and HflK could
D3869_12310	COG0330	HflC and HflK could
D3869_12335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D3869_12340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3869_12345	COG0028	Belongs to the TPP enzyme family
D3869_12360	COG0704	Plays a role in the regulation of phosphate uptake
D3869_12365	COG2862	Uncharacterized protein family, UPF0114
D3869_12385	COG0768	penicillin binding
D3869_12425	COG0295	cytidine deaminase activity
D3869_12430	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3869_12435	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D3869_12450	COG0697	spore germination
D3869_12470	COG0411	ABC transporter
D3869_12485	COG0038	chloride channel
D3869_12505	COG2326	polyphosphate kinase activity
D3869_12510	COG0366	Alpha amylase catalytic
D3869_12520	COG2203	Gaf domain
D3869_12520	COG2200	EAL domain
D3869_12520	COG2199	diguanylate cyclase activity
D3869_12530	COG2135	peptidase activity
D3869_12540	COG0784	Response regulator, receiver
D3869_12545	COG2261	transglycosylase associated protein
D3869_12550	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3869_12565	COG1733	regulation of RNA biosynthetic process
D3869_12580	COG2084	Dehydrogenase
D3869_12585	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_12600	COG0546	phosphoglycolate phosphatase activity
D3869_12615	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3869_12625	COG2832	Protein of unknown function (DUF454)
D3869_12630	COG1238	metal cluster binding
D3869_12635	COG3852	Histidine kinase
D3869_12640	COG0469	pyruvate kinase activity
D3869_12645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D3869_12660	COG0203	ribosomal protein L17
D3869_12665	COG1238	metal cluster binding
D3869_12680	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D3869_12695	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D3869_12700	COG0564	pseudouridine synthase activity
D3869_12705	COG1802	Transcriptional regulator
D3869_12710	COG3135	benzoate transporter
D3869_12715	COG0546	phosphoglycolate phosphatase activity
D3869_12740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3869_12745	COG1129	ABC transporter
D3869_12785	COG3706	GGDEF domain
D3869_12785	COG0745	RESPONSE REGULATOR receiver
D3869_12790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3869_12795	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3869_12810	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_12815	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3869_12820	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D3869_12830	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D3869_12835	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3869_12840	COG0351	phosphomethylpyrimidine kinase
D3869_12840	COG0352	thiamine-phosphate diphosphorylase activity
D3869_12845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3869_12860	COG0670	Belongs to the BI1 family
D3869_12880	COG1012	belongs to the aldehyde dehydrogenase family
D3869_12880	COG2030	dehydratase
D3869_12885	COG0443	Heat shock 70 kDa protein
D3869_12910	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D3869_12910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3869_12960	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3869_12965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3869_12975	COG0649	NAD binding
D3869_12980	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D3869_12990	COG1034	ATP synthesis coupled electron transport
D3869_12995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D3869_13000	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3869_13010	COG0713	ATP synthesis coupled electron transport
D3869_13025	COG1007	ATP synthesis coupled electron transport
D3869_13055	COG0519	Catalyzes the synthesis of GMP from XMP
D3869_13070	COG0442	prolyl-tRNA aminoacylation
D3869_13100	COG0587	DNA-directed DNA polymerase activity
D3869_13110	COG5634	Uncharacterized conserved protein (DUF2278)
D3869_13115	COG0052	Belongs to the universal ribosomal protein uS2 family
D3869_13120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D3869_13125	COG0528	UMP kinase activity
D3869_13130	COG0233	cytoplasmic translational termination
D3869_13135	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3869_13140	COG0575	Belongs to the CDS family
D3869_13145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D3869_13150	COG0750	zinc metalloprotease
D3869_13170	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3869_13175	COG3494	Protein of unknown function (DUF1009)
D3869_13180	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3869_13195	COG0583	DNA-binding transcription factor activity
D3869_13210	COG0372	Belongs to the citrate synthase family
D3869_13215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3869_13220	COG2333	competence protein COMEC
D3869_13220	COG0658	competence protein
D3869_13225	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3869_13230	COG0303	'Molybdopterin
D3869_13235	COG0315	cyclic pyranopterin monophosphate synthase activity
D3869_13280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3869_13290	COG0149	triose-phosphate isomerase activity
D3869_13320	COG0535	radical SAM domain protein
D3869_13325	COG0535	radical SAM domain protein
D3869_13330	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
D3869_13335	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D3869_13345	COG0148	phosphopyruvate hydratase activity
D3869_13355	COG0037	tRNA processing
D3869_13380	COG2986	histidine ammonia-lyase
D3869_13390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_13410	COG0596	Alpha beta hydrolase
D3869_13415	COG0728	peptidoglycan biosynthetic process
D3869_13425	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3869_13440	COG0436	Aminotransferase
D3869_13460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_13465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3869_13490	COG0745	RESPONSE REGULATOR receiver
D3869_13525	COG5002	protein histidine kinase activity
D3869_13525	COG3447	MASE1 domain protein
D3869_13525	COG5001	Diguanylate cyclase
D3869_13540	COG1324	tolerance protein
D3869_13560	COG1024	Enoyl-CoA hydratase
D3869_13570	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D3869_13575	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D3869_13580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D3869_13585	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D3869_13590	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
D3869_13590	COG2885	chlorophyll binding
D3869_13595	COG3243	poly(R)-hydroxyalkanoic acid synthase
D3869_13610	COG2814	Major facilitator Superfamily
D3869_13615	COG0436	Aminotransferase
D3869_13625	COG1494	fructose-1,6-bisphosphatase
D3869_13630	COG0371	Dehydrogenase
D3869_13635	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D3869_13635	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D3869_13685	COG0656	L-ascorbic acid biosynthetic process
D3869_13700	COG0123	including yeast histone deacetylase and acetoin utilization protein
D3869_13710	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3869_13715	COG0517	IMP dehydrogenase activity
D3869_13720	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3869_13725	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3869_13730	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D3869_13750	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_13755	COG0045	succinate-CoA ligase (ADP-forming) activity
D3869_13765	COG0583	DNA-binding transcription factor activity
D3869_13770	COG2814	Major facilitator Superfamily
D3869_13785	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D3869_13800	COG2084	Dehydrogenase
D3869_13805	COG3622	Belongs to the hyi family
D3869_13810	COG3960	tartronate-semialdehyde synthase activity
D3869_13815	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D3869_13815	COG0352	thiamine-phosphate diphosphorylase activity
D3869_13820	COG1802	Transcriptional regulator
D3869_13825	COG0469	pyruvate kinase activity
D3869_13835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3869_13835	COG0574	Belongs to the PEP-utilizing enzyme family
D3869_13860	COG3283	Transcriptional regulator of aromatic amino acids metabolism
D3869_13865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3869_13875	COG0693	protein deglycase activity
D3869_13880	COG2197	response regulator
D3869_13885	COG2197	response regulator
D3869_13900	COG0829	nickel cation binding
D3869_13905	COG1819	glycosyl
D3869_13910	COG0831	urea catabolic process
D3869_13915	COG0832	Belongs to the urease beta subunit family
D3869_13920	COG0804	urea catabolic process
D3869_13945	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
D3869_13970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3869_13975	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D3869_14015	COG1561	YicC-like family, N-terminal region
D3869_14020	COG0300	oxidoreductase activity
D3869_14025	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3869_14030	COG3932	Exopolysaccharide synthesis, ExoD
D3869_14035	COG0488	(ABC) transporter
D3869_14040	COG0105	UTP biosynthetic process
D3869_14055	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D3869_14060	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D3869_14070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3869_14075	COG0628	permease
D3869_14085	COG0300	oxidoreductase activity
D3869_14090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D3869_14115	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3869_14120	COG0248	Ppx GppA phosphatase
D3869_14130	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D3869_14135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D3869_14155	COG5002	protein histidine kinase activity
D3869_14155	COG5001	Diguanylate cyclase
D3869_14155	COG3447	MASE1 domain protein
D3869_14160	COG2202	Pas domain
D3869_14160	COG2205	protein histidine kinase activity
D3869_14165	COG0784	Response regulator, receiver
D3869_14170	COG3706	GGDEF domain
D3869_14170	COG0745	RESPONSE REGULATOR receiver
D3869_14175	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D3869_14180	COG0793	Belongs to the peptidase S41A family
D3869_14185	COG0557	exoribonuclease II activity
D3869_14195	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3869_14200	COG0758	DNA mediated transformation
D3869_14220	COG2814	Major facilitator Superfamily
D3869_14255	COG2205	protein histidine kinase activity
D3869_14255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_14260	COG0745	RESPONSE REGULATOR receiver
D3869_14295	COG0581	inorganic phosphate transmembrane transporter activity
D3869_14300	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_14310	COG3842	ATPase activity
D3869_14320	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3869_14325	COG1732	Glycine betaine
D3869_14330	COG1174	glycine betaine transport
D3869_14335	COG1125	glycine betaine transport
D3869_14340	COG1174	glycine betaine transport
D3869_14350	COG1652	LysM domain
D3869_14355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3869_14365	COG1024	Enoyl-CoA hydratase
D3869_14370	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D3869_14375	COG1609	Transcriptional regulator
D3869_14380	COG3265	gluconokinase activity
D3869_14395	COG1609	Transcriptional regulator
D3869_14400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3869_14405	COG1126	abc transporter atp-binding protein
D3869_14415	COG0765	amino acid transport
D3869_14420	COG0765	amino acid transport
D3869_14425	COG0303	'Molybdopterin
D3869_14445	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_14450	COG0730	response to heat
D3869_14465	COG0717	Belongs to the dCTP deaminase family
D3869_14475	COG0625	glutathione transferase activity
D3869_14480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3869_14500	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3869_14500	COG2813	Specifically methylates the guanine in position
D3869_14505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3869_14515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3869_14520	COG0287	Prephenate dehydrogenase
D3869_14530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D3869_14545	COG0583	DNA-binding transcription factor activity
D3869_14550	COG0450	alkyl hydroperoxide reductase
D3869_14555	COG3634	alkyl hydroperoxide reductase activity
D3869_14560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3869_14565	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3869_14570	COG2080	2 iron, 2 sulfur cluster binding
D3869_14580	COG1988	membrane-bound metal-dependent
D3869_14605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D3869_14610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3869_14615	COG0540	Belongs to the ATCase OTCase family
D3869_14630	COG0583	DNA-binding transcription factor activity
D3869_14650	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D3869_14665	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D3869_14675	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3869_14680	COG0154	amidase activity
D3869_14685	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3869_14715	COG1733	regulation of RNA biosynthetic process
D3869_14720	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_14720	COG3321	synthase
D3869_14720	COG0604	alcohol dehydrogenase
D3869_14745	COG0628	permease
D3869_14750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3869_14840	COG1012	belongs to the aldehyde dehydrogenase family
D3869_14855	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_14880	COG0583	DNA-binding transcription factor activity
D3869_14885	COG0583	DNA-binding transcription factor activity
D3869_14890	COG4221	oxidoreductase activity
D3869_14905	COG2080	2 iron, 2 sulfur cluster binding
D3869_14910	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3869_14915	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3869_14935	COG0583	DNA-binding transcription factor activity
D3869_14965	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3869_14970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_14980	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D3869_14985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3869_15010	COG0667	Aldo Keto reductase
D3869_15015	COG0583	DNA-binding transcription factor activity
D3869_15020	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D3869_15055	COG2703	oxygen carrier activity
D3869_15070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D3869_15075	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3869_15080	COG1127	ABC transporter
D3869_15100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3869_15105	COG1271	oxidase subunit
D3869_15110	COG1294	oxidase, subunit
D3869_15140	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_15165	COG2089	acid synthase
D3869_15170	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D3869_15195	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_15200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3869_15205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3869_15205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3869_15215	COG0859	PFAM glycosyl transferase family 9
D3869_15215	COG0457	Tetratricopeptide repeat
D3869_15225	COG0859	PFAM glycosyl transferase family 9
D3869_15225	COG0457	Tetratricopeptide repeat
D3869_15275	COG0784	Response regulator, receiver
D3869_15300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3869_15305	COG3394	polysaccharide catabolic process
D3869_15310	COG1228	amidohydrolase
D3869_15325	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D3869_15340	COG2226	methyltransferase
D3869_15350	COG0747	negative chemotaxis
D3869_15360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_15365	COG0444	Belongs to the ABC transporter superfamily
D3869_15370	COG4608	Belongs to the ABC transporter superfamily
D3869_15405	COG1666	GTP binding
D3869_15425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3869_15460	COG1752	Esterase of the alpha-beta hydrolase superfamily
D3869_15465	COG1132	(ABC) transporter
D3869_15470	COG4191	Histidine kinase
D3869_15495	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D3869_15505	COG2264	protein methyltransferase activity
D3869_15510	COG0583	DNA-binding transcription factor activity
D3869_15515	COG0655	NAD(P)H dehydrogenase (quinone) activity
D3869_15520	COG0435	Glutathione S-transferase
D3869_15530	COG2197	response regulator
D3869_15540	COG0492	ferredoxin-NADP+ reductase activity
D3869_15570	COG3038	cytochrome b561
D3869_15575	COG3240	lipase activity
D3869_15590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3869_15600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3869_15610	COG1846	Transcriptional regulator
D3869_15620	COG3920	Histidine kinase
D3869_15635	COG1758	RNA polymerase activity
D3869_15645	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D3869_15650	COG0736	holo-[acyl-carrier-protein] synthase activity
D3869_15655	COG0681	Belongs to the peptidase S26 family
D3869_15660	COG0571	ribonuclease III activity
D3869_15665	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D3869_15670	COG3106	COG3106 Predicted ATPase
D3869_15675	COG3768	UPF0283 membrane protein
D3869_15695	COG0740	serine-type endopeptidase activity
D3869_15700	COG1215	transferase activity, transferring glycosyl groups
D3869_15705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3869_15710	COG1566	PFAM secretion protein HlyD family protein
D3869_15715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3869_15725	COG2308	Evidence 4 Homologs of previously reported genes of
D3869_15725	COG2307	Protein conserved in bacteria
D3869_15745	COG2017	converts alpha-aldose to the beta-anomer
D3869_15750	COG2815	serine threonine protein kinase
D3869_15750	COG0515	serine threonine protein kinase
D3869_15755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D3869_15795	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D3869_15805	COG0513	Belongs to the DEAD box helicase family
D3869_15830	COG0187	DNA topoisomerase II activity
D3869_15835	COG1607	acyl-coa hydrolase
D3869_15840	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D3869_15845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3869_15850	COG0022	dehydrogenase e1 component
D3869_15850	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3869_15855	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3869_15860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3869_15865	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3869_15870	COG2867	negative regulation of translational initiation
D3869_15875	COG1546	Belongs to the CinA family
D3869_15875	COG1058	Belongs to the CinA family
D3869_15910	COG2204	response regulator
D3869_15920	COG0569	domain protein
D3869_15935	COG1923	regulation of RNA biosynthetic process
D3869_15940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3869_15955	COG0483	inositol monophosphate 1-phosphatase activity
D3869_15970	COG3956	TIGRFAM MazG family protein
D3869_15975	COG3260	NADH ubiquinone oxidoreductase 20
D3869_15980	COG0649	NAD binding
D3869_15985	COG0651	ATP synthesis coupled electron transport
D3869_15995	COG0650	Formate hydrogenlyase subunit 4
D3869_16000	COG0651	ATP synthesis coupled electron transport
D3869_16005	COG2183	response to ionizing radiation
D3869_16015	COG1280	lysine exporter protein (LysE YggA)
D3869_16060	COG0393	Putative heavy-metal-binding
D3869_16065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3869_16080	COG4166	transmembrane transport
D3869_16085	COG0625	glutathione transferase activity
D3869_16090	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3869_16095	COG0366	Alpha amylase catalytic
D3869_16115	COG0840	transmembrane signaling receptor activity
D3869_16150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3869_16160	COG0583	DNA-binding transcription factor activity
D3869_16165	COG4336	lyase activity
D3869_16180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_16185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D3869_16190	COG1984	allophanate hydrolase subunit 2
D3869_16195	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D3869_16205	COG4191	Histidine kinase
D3869_16210	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D3869_16215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3869_16220	COG0058	SHG alpha-glucan phosphorylase activity
D3869_16270	COG5002	protein histidine kinase activity
D3869_16275	COG0745	RESPONSE REGULATOR receiver
D3869_16305	COG1959	2 iron, 2 sulfur cluster binding
D3869_16310	COG0719	Fe-S assembly protein
D3869_16315	COG0396	ATPase activity
D3869_16320	COG0719	Fe-S assembly protein
D3869_16325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3869_16330	COG0822	iron-sulfur transferase activity
D3869_16340	COG0316	Belongs to the HesB IscA family
D3869_16350	COG0308	aminopeptidase N
D3869_16370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3869_16405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3869_16410	COG0697	spore germination
D3869_16420	COG2814	Major facilitator Superfamily
D3869_16425	COG0583	DNA-binding transcription factor activity
D3869_16440	COG3383	formate dehydrogenase (NAD+) activity
D3869_16445	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3869_16465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3869_16470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3869_16495	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3869_16505	COG0129	dihydroxy-acid dehydratase activity
D3869_16515	COG3920	Histidine kinase
D3869_16540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D3869_16545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3869_16550	COG0534	Mate efflux family protein
D3869_16600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3869_16665	COG0629	single-stranded DNA binding
D3869_16670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3869_16690	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D3869_16705	COG1562	ergosterol biosynthetic process
D3869_16710	COG1562	ergosterol biosynthetic process
D3869_16715	COG1233	COG1233 Phytoene dehydrogenase and related
D3869_16725	COG3737	Protein of unknown function (DUF498/DUF598)
D3869_16755	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3869_16765	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3869_16770	COG0745	RESPONSE REGULATOR receiver
D3869_16770	COG3706	GGDEF domain
D3869_16775	COG0805	protein transport
D3869_16780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3869_16785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3869_16790	COG3842	ATPase activity
D3869_16795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D3869_16800	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D3869_16805	COG1994	Peptidase M50
D3869_16810	COG1472	Belongs to the glycosyl hydrolase 3 family
D3869_16825	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D3869_16830	COG0316	Belongs to the HesB IscA family
D3869_16835	COG0708	Exodeoxyribonuclease III
D3869_16895	COG4372	Transposase
D3869_16900	COG3436	PFAM IS66 Orf2 family protein
D3869_16965	COG3177	Filamentation induced by cAMP protein fic
D3869_16995	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3869_17025	COG0519	Catalyzes the synthesis of GMP from XMP
D3869_17030	COG1247	-acetyltransferase
D3869_17065	COG3813	Protein conserved in bacteria
D3869_17070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3869_17070	COG0357	Ribosomal RNA small subunit methyltransferase G
D3869_17095	COG2814	Major facilitator Superfamily
D3869_17105	COG3706	GGDEF domain
D3869_17105	COG0745	RESPONSE REGULATOR receiver
D3869_17110	COG0066	3-isopropylmalate dehydratase activity
D3869_17115	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3869_17125	COG1335	isochorismatase
D3869_17165	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_17170	COG0683	leucine binding
D3869_17175	COG2188	Transcriptional regulator
D3869_17200	COG0411	ABC transporter
D3869_17220	COG0784	Response regulator, receiver
D3869_17220	COG5002	protein histidine kinase activity
D3869_17220	COG2198	Histidine kinase
D3869_17240	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3869_17250	COG0444	Belongs to the ABC transporter superfamily
D3869_17255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_17260	COG0601	transmembrane transport
D3869_17315	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D3869_17345	COG2862	Uncharacterized protein family, UPF0114
D3869_17460	COG3501	Rhs element vgr protein
D3869_17475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3869_17495	COG4771	TonB-dependent receptor
D3869_17515	COG1169	isochorismate synthase
D3869_17520	COG1021	2,3-dihydroxybenzoate-AMP ligase
D3869_17525	COG3433	isochorismatase activity
D3869_17525	COG1535	isochorismatase
D3869_17530	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_17540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3869_17545	COG2382	esterase
D3869_17555	COG1595	DNA-templated transcription, initiation
D3869_17565	COG1882	Formate acetyltransferase
D3869_17575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3869_17575	COG3008	intermembrane lipid transfer
D3869_17580	COG2995	paraquat-inducible protein a
D3869_17590	COG0457	Tetratricopeptide repeat
D3869_17590	COG0859	PFAM glycosyl transferase family 9
D3869_17595	COG0281	malic enzyme
D3869_17595	COG0280	phosphate acetyltransferase
D3869_17600	COG1301	dicarboxylic acid transport
D3869_17605	COG4191	Histidine kinase
D3869_17610	COG2204	response regulator
D3869_17635	COG1268	BioY protein
D3869_17645	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3869_17655	COG1794	racemase activity, acting on amino acids and derivatives
D3869_17675	COG1012	belongs to the aldehyde dehydrogenase family
D3869_17685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_17690	COG3976	FMN-binding domain protein
D3869_17690	COG1053	succinate dehydrogenase
D3869_17690	COG0431	NADPH-dependent FMN reductase
D3869_17710	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_17720	COG0745	RESPONSE REGULATOR receiver
D3869_17725	COG0745	RESPONSE REGULATOR receiver
D3869_17730	COG4251	negative regulation of phosphorylation
D3869_17740	COG1733	regulation of RNA biosynthetic process
D3869_17745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3869_17750	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_17790	COG0583	DNA-binding transcription factor activity
D3869_17800	COG2084	Dehydrogenase
D3869_17805	COG0300	oxidoreductase activity
D3869_17855	COG1396	sequence-specific DNA binding
D3869_17895	COG0247	lactate metabolic process
D3869_17895	COG0277	FAD linked oxidase domain protein
D3869_17925	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D3869_17935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D3869_17955	COG0425	Belongs to the sulfur carrier protein TusA family
D3869_17965	COG0640	Transcriptional regulator
D3869_17985	COG2857	Cytochrome c1
D3869_17985	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D3869_18000	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D3869_18005	COG0408	coproporphyrinogen oxidase activity
D3869_18010	COG0617	tRNA 3'-terminal CCA addition
D3869_18030	COG0714	Associated with various cellular activities
D3869_18065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3869_18100	COG3436	PFAM IS66 Orf2 family protein
D3869_18105	COG4372	Transposase
D3869_18135	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D3869_18180	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_18185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3869_18245	COG2099	Precorrin-6x reductase
D3869_18275	COG1797	cobyrinic acid a,c-diamide synthase activity
D3869_18280	COG0778	Nitroreductase
D3869_18285	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_18290	COG1309	transcriptional regulator
D3869_18295	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3869_18300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3869_18305	COG0737	Belongs to the 5'-nucleotidase family
D3869_18310	COG4191	Histidine kinase
D3869_18310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_18330	COG1749	Flagellar hook protein flgE
D3869_18330	COG1749	Flagellar hook protein flgE
D3869_18355	COG0795	lipopolysaccharide-transporting ATPase activity
D3869_18360	COG0840	transmembrane signaling receptor activity
D3869_18365	COG1137	ATPase activity
D3869_18375	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_18430	COG2723	6-phospho-beta-galactosidase activity
D3869_18445	COG2086	electron transfer activity
D3869_18455	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3869_18465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3869_18480	COG0019	diaminopimelate decarboxylase activity
D3869_18505	COG0772	Belongs to the SEDS family
D3869_18510	COG1253	flavin adenine dinucleotide binding
D3869_18520	COG2205	protein histidine kinase activity
D3869_18535	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D3869_18555	COG1657	PFAM Prenyltransferase squalene oxidase
D3869_18580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_18590	COG2217	Heavy metal translocating P-type atpase
D3869_18615	COG1741	Belongs to the pirin family
D3869_18620	COG2860	membrane
D3869_18630	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3869_18635	COG0789	Transcriptional regulator
D3869_18650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3869_18700	COG1566	PFAM secretion protein HlyD family protein
D3869_18710	COG0583	DNA-binding transcription factor activity
D3869_18715	COG2814	Major facilitator Superfamily
D3869_18735	COG0471	metal ion transport
D3869_18735	COG3273	potassium ion transport
D3869_18765	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_18775	COG0583	DNA-binding transcription factor activity
D3869_18780	COG3842	ATPase activity
D3869_18785	COG2182	Extracellular solute-binding protein
D3869_18790	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_18800	COG1917	Cupin 2, conserved barrel domain protein
D3869_18800	COG1396	sequence-specific DNA binding
D3869_18810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3869_18820	COG5507	3-demethylubiquinone-9 3-methyltransferase
D3869_18835	COG1309	transcriptional regulator
D3869_18860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3869_18870	COG1522	sequence-specific DNA binding
D3869_18875	COG1192	Involved in chromosome partitioning
D3869_18905	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D3869_18910	COG1530	ribonuclease E activity
D3869_18920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D3869_18935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3869_18945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D3869_18970	COG5002	protein histidine kinase activity
D3869_18995	COG0588	phosphoglycerate mutase activity
D3869_19010	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D3869_19020	COG3693	PFAM glycoside hydrolase, family 10
D3869_19030	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3869_19055	COG1215	transferase activity, transferring glycosyl groups
D3869_19060	COG0438	transferase activity, transferring glycosyl groups
D3869_19065	COG0438	transferase activity, transferring glycosyl groups
D3869_19085	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_19090	COG0367	asparagine synthase
D3869_19095	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D3869_19135	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D3869_19140	COG4208	sulfate ABC transporter
D3869_19150	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D3869_19160	COG1959	2 iron, 2 sulfur cluster binding
D3869_19165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3869_19190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_19215	COG1573	uracil-dna glycosylase
D3869_19220	COG0741	lytic transglycosylase activity
D3869_19225	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3869_19260	COG0438	transferase activity, transferring glycosyl groups
D3869_19300	COG1960	acyl-CoA dehydrogenase activity
D3869_19310	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D3869_19325	COG0583	DNA-binding transcription factor activity
D3869_19330	COG2080	2 iron, 2 sulfur cluster binding
D3869_19335	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D3869_19340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3869_19360	COG2900	Belongs to the SlyX family
D3869_19445	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3869_19445	COG0596	Alpha beta hydrolase
D3869_19450	COG0022	dehydrogenase e1 component
D3869_19455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3869_19460	COG3199	ATP-NAD kinase
D3869_19465	COG3284	Transcriptional regulator
D3869_19495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3869_19500	COG1414	Transcriptional regulator
D3869_19505	COG2376	Dihydroxyacetone kinase
D3869_19545	COG0420	3'-5' exonuclease activity
D3869_19550	COG0419	ATPase involved in DNA repair
D3869_19555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3869_19565	COG1192	Involved in chromosome partitioning
D3869_19570	COG1475	DNA binding
D3869_19585	COG3707	response regulator
D3869_19590	COG1116	anion transmembrane transporter activity
D3869_19600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3869_19605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3869_19610	COG2146	nitrite reductase [NAD(P)H] activity
D3869_19615	COG0243	molybdopterin cofactor binding
D3869_19620	COG1648	precorrin-2 dehydrogenase activity
D3869_19620	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3869_19625	COG0791	NLP P60 protein
D3869_19635	COG1032	radical SAM domain protein
D3869_19680	COG1609	Transcriptional regulator
D3869_19685	COG0583	DNA-binding transcription factor activity
D3869_19700	COG3648	Uricase
D3869_19700	COG3195	allantoin biosynthetic process
D3869_19710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3869_19730	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D3869_19770	COG0243	molybdopterin cofactor binding
D3869_19770	COG3383	formate dehydrogenase (NAD+) activity
D3869_19775	COG0437	4 iron, 4 sulfur cluster binding
D3869_19780	COG2864	formate dehydrogenase
D3869_19785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3869_19805	COG1116	anion transmembrane transporter activity
D3869_19810	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_19820	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_19835	COG0745	RESPONSE REGULATOR receiver
D3869_19840	COG3850	Histidine kinase
D3869_19840	COG0642	Histidine kinase
D3869_19875	COG2223	nitrite transmembrane transporter activity
D3869_19910	COG1137	ATPase activity
D3869_19915	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D3869_19920	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3869_19925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3869_19930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3869_19935	COG0527	aspartate kinase activity
D3869_19940	COG2070	2-Nitropropane dioxygenase
D3869_19955	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D3869_19960	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D3869_19970	COG2852	Protein conserved in bacteria
D3869_19975	COG2890	protein-(glutamine-N5) methyltransferase activity
D3869_19995	COG0542	response to heat
D3869_20000	COG1272	protein, Hemolysin III
D3869_20010	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D3869_20025	COG0840	transmembrane signaling receptor activity
D3869_20030	COG5265	(ABC) transporter
D3869_20040	COG1703	isobutyryl-CoA mutase activity
D3869_20050	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D3869_20060	COG2137	regulation of response to DNA damage stimulus
D3869_20065	COG0842	Transport permease protein
D3869_20070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3869_20075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D3869_20080	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D3869_20090	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D3869_20095	COG0671	phosphoesterase, PA-phosphatase related
D3869_20110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3869_20115	COG4774	siderophore transport
D3869_20120	COG3128	pkhd-type hydroxylase
D3869_20135	COG4604	ABC transporter, ATP-binding protein
D3869_20140	COG4605	iron ion homeostasis
D3869_20145	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3869_20150	COG4607	ABC-type enterochelin transport system periplasmic component
D3869_20155	COG1695	Transcriptional regulator
D3869_20195	COG1116	anion transmembrane transporter activity
D3869_20260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3869_20270	COG4206	TonB-dependent receptor
D3869_20305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3869_20310	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3869_20310	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3869_20315	COG1660	Displays ATPase and GTPase activities
D3869_20320	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D3869_20330	COG0642	Histidine kinase
D3869_20335	COG0745	RESPONSE REGULATOR receiver
D3869_20350	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D3869_20365	COG0739	heme binding
D3869_20400	COG3436	PFAM IS66 Orf2 family protein
D3869_20405	COG4372	Transposase
D3869_20425	COG1942	4-Oxalocrotonate Tautomerase
D3869_20430	COG0235	Class ii aldolase
D3869_20440	COG2205	protein histidine kinase activity
D3869_20445	COG0745	RESPONSE REGULATOR receiver
D3869_20460	COG0840	transmembrane signaling receptor activity
D3869_20470	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3869_20480	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D3869_20505	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D3869_20510	COG2027	D-alanyl-D-alanine carboxypeptidase
D3869_20520	COG2091	lysine biosynthetic process via aminoadipic acid
D3869_20525	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3869_20530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3869_20540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3869_20540	COG2111	Na H antiporter
D3869_20545	COG1006	Multisubunit Na H antiporter MnhC subunit
D3869_20550	COG0651	ATP synthesis coupled electron transport
D3869_20555	COG1863	multisubunit Na H antiporter MnhE subunit
D3869_20560	COG2212	antiporter activity
D3869_20565	COG1320	monovalent cation:proton antiporter activity
D3869_20605	COG4615	Cyclic peptide transporter
D3869_20635	COG0683	leucine binding
D3869_20665	COG3842	ATPase activity
D3869_20675	COG1175	transmembrane transport
D3869_20695	COG1024	Enoyl-CoA hydratase
D3869_20710	COG4221	oxidoreductase activity
D3869_20715	COG1609	Transcriptional regulator
D3869_20745	COG1966	Carbon starvation protein
D3869_20750	COG2879	small protein
D3869_20770	COG3243	poly(R)-hydroxyalkanoic acid synthase
D3869_20780	COG4651	solute:proton antiporter activity
D3869_20780	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3869_20795	COG4191	Histidine kinase
D3869_20795	COG0784	Response regulator, receiver
D3869_20820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3869_20825	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3869_20840	COG2204	response regulator
D3869_20855	COG0187	DNA topoisomerase II activity
D3869_20860	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D3869_20865	COG0592	DNA-directed DNA polymerase activity
D3869_20920	COG4566	intracellular signal transduction
D3869_20925	COG4191	Histidine kinase
D3869_20930	COG1335	isochorismatase
D3869_20995	COG0625	glutathione transferase activity
D3869_21000	COG0583	DNA-binding transcription factor activity
D3869_21005	COG4948	Mandelate Racemase Muconate Lactonizing
D3869_21015	COG0288	reversible hydration of carbon dioxide
D3869_21025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D3869_21040	COG0583	DNA-binding transcription factor activity
D3869_21050	COG1283	sodium-dependent phosphate transmembrane transporter activity
D3869_21110	COG0306	phosphate transporter
D3869_21115	COG1392	Phosphate transport regulator
D3869_21125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3869_21150	COG2223	nitrite transmembrane transporter activity
D3869_21180	COG0612	Peptidase, M16
D3869_21190	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D3869_21210	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3869_21220	COG0488	(ABC) transporter
D3869_21235	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3869_21240	COG0583	DNA-binding transcription factor activity
D3869_21250	COG0586	Pfam SNARE associated Golgi protein
D3869_21280	COG2884	Cell division ATP-binding protein ftsE
D3869_21290	COG1309	transcriptional regulator
D3869_21315	COG5001	Diguanylate cyclase
D3869_21320	COG1381	Involved in DNA repair and RecF pathway recombination
D3869_21325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3869_21330	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3869_21335	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_21355	COG2308	Evidence 4 Homologs of previously reported genes of
D3869_21360	COG1360	Flagellar Motor Protein
D3869_21365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3869_21375	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3869_21400	COG2198	Histidine kinase
D3869_21400	COG0643	Histidine kinase
D3869_21405	COG0835	chemotaxis
D3869_21410	COG0745	RESPONSE REGULATOR receiver
D3869_21425	COG0583	DNA-binding transcription factor activity
D3869_21435	COG0745	RESPONSE REGULATOR receiver
D3869_21440	COG1157	protein secretion by the type III secretion system
D3869_21455	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3869_21465	COG0455	bacterial-type flagellum organization
D3869_21470	COG0552	protein localization to endoplasmic reticulum
D3869_21475	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3869_21480	COG2204	response regulator
D3869_21485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3869_21490	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3869_21500	COG1766	The M ring may be actively involved in energy transduction
D3869_21505	COG1396	sequence-specific DNA binding
D3869_21545	COG1686	Belongs to the peptidase S11 family
D3869_21560	COG1840	ABC-type Fe3 transport system, periplasmic component
D3869_21565	COG4149	molybdate abc transporter
D3869_21570	COG3842	ATPase activity
D3869_21585	COG2391	methyltransferase activity
D3869_21590	COG0583	DNA-binding transcription factor activity
D3869_21595	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D3869_21600	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D3869_21630	COG0246	Mannitol dehydrogenase
D3869_21635	COG2721	sulfolactate sulfo-lyase activity
D3869_21640	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_21650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_21655	COG1063	alcohol dehydrogenase
D3869_21700	COG3264	Mechanosensitive ion channel
D3869_21700	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D3869_21710	COG2814	Major facilitator Superfamily
D3869_21715	COG0386	Belongs to the glutathione peroxidase family
D3869_21725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3869_21735	COG0837	glucose binding
D3869_21735	COG1737	Transcriptional regulator
D3869_21740	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3869_21745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_21750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_21760	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3869_21775	COG0436	Aminotransferase
D3869_21780	COG2202	Pas domain
D3869_21780	COG2205	protein histidine kinase activity
D3869_21785	COG2373	Large extracellular alpha-helical protein
D3869_21800	COG0183	Belongs to the thiolase family
D3869_21805	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3869_21805	COG1024	Enoyl-CoA hydratase
D3869_21810	COG1960	acyl-CoA dehydrogenase activity
D3869_21825	COG3047	cAMP biosynthetic process
D3869_21840	COG1196	nuclear chromosome segregation
D3869_21855	COG1194	a g-specific adenine glycosylase
D3869_21865	COG4191	Histidine kinase
D3869_21865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_21875	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D3869_21885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_21885	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3869_21890	COG3012	SEC-C Motif Domain Protein
D3869_21895	COG1278	Cold shock
D3869_21900	COG0793	Belongs to the peptidase S41A family
D3869_21910	COG0309	Hydrogenase expression formation protein (HypE)
D3869_21915	COG0298	carbon dioxide binding
D3869_21930	COG0375	protein maturation
D3869_21940	COG1773	rubredoxin
D3869_21945	COG0298	carbon dioxide binding
D3869_21960	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3869_21965	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D3869_21970	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D3869_21975	COG5557	Pfam Polysulphide reductase, NrfD
D3869_21980	COG0437	4 iron, 4 sulfur cluster binding
D3869_21985	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D3869_22000	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D3869_22025	COG4178	(ABC) transporter
D3869_22035	COG0625	glutathione transferase activity
D3869_22065	COG1640	4-alpha-glucanotransferase
D3869_22080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3869_22090	COG2205	protein histidine kinase activity
D3869_22095	COG0745	RESPONSE REGULATOR receiver
D3869_22100	COG2205	protein histidine kinase activity
D3869_22100	COG2198	Histidine kinase
D3869_22100	COG0784	Response regulator, receiver
D3869_22105	COG1278	Cold shock
D3869_22115	COG1846	Transcriptional regulator
D3869_22120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3869_22125	COG0556	nucleotide-excision repair
D3869_22145	COG2205	protein histidine kinase activity
D3869_22155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3869_22165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3869_22170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D3869_22185	COG0741	lytic transglycosylase activity
D3869_22225	COG1309	transcriptional regulator
D3869_22240	COG1418	mRNA catabolic process
D3869_22245	COG1131	(ABC) transporter
D3869_22250	COG0842	Transport permease protein
D3869_22255	COG3791	Glutathione-dependent formaldehyde-activating
D3869_22260	COG0154	amidase activity
D3869_22265	COG0154	amidase activity
D3869_22270	COG1335	isochorismatase
D3869_22275	COG0747	negative chemotaxis
D3869_22295	COG4608	Belongs to the ABC transporter superfamily
D3869_22300	COG1335	isochorismatase
D3869_22305	COG3180	Ammonia monooxygenase
D3869_22310	COG1802	Transcriptional regulator
D3869_22320	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D3869_22325	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D3869_22330	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D3869_22335	COG2205	protein histidine kinase activity
D3869_22345	COG0861	Integral membrane protein TerC family
D3869_22355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_22360	COG2353	YceI-like domain
D3869_22380	COG4566	intracellular signal transduction
D3869_22385	COG4566	intracellular signal transduction
D3869_22390	COG4191	Histidine kinase
D3869_22400	COG1538	Outer membrane efflux protein
D3869_22405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3869_22410	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3869_22430	COG0339	signal peptide processing
D3869_22435	COG4175	Glycine betaine
D3869_22440	COG4176	ABC-type proline glycine betaine transport system permease component
D3869_22445	COG2113	Glycine betaine
D3869_22465	COG1764	response to oxidative stress
D3869_22470	COG1846	Transcriptional regulator
D3869_22490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_22495	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3869_22515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3869_22565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3869_22570	COG0392	lysyltransferase activity
D3869_22585	COG5001	Diguanylate cyclase
D3869_22595	COG0328	RNA-DNA hybrid ribonuclease activity
D3869_22595	COG0406	alpha-ribazole phosphatase activity
D3869_22600	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3869_22615	COG0477	Major facilitator Superfamily
D3869_22620	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3869_22625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3869_22630	COG1845	cytochrome c oxidase, subunit III
D3869_22635	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D3869_22650	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D3869_22665	COG3005	denitrification pathway
D3869_22690	COG4459	periplasmic nitrate reductase
D3869_22705	COG0670	Belongs to the BI1 family
D3869_22735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_22745	COG1850	ribulose-bisphosphate carboxylase activity
D3869_22755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_22760	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_22775	COG3246	L-lysine catabolic process to acetate
D3869_22780	COG0028	Belongs to the TPP enzyme family
D3869_22800	COG4172	Belongs to the ABC transporter superfamily
D3869_22805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_22820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3869_22825	COG0583	DNA-binding transcription factor activity
D3869_22855	COG0438	transferase activity, transferring glycosyl groups
D3869_22875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_22895	COG0438	transferase activity, transferring glycosyl groups
D3869_22900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_22905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_22910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3869_22925	COG2197	response regulator
D3869_22930	COG2197	response regulator
D3869_22940	COG3387	PFAM Glycoside hydrolase 15-related
D3869_22970	COG2226	methyltransferase
D3869_22985	COG0784	Response regulator, receiver
D3869_22985	COG5002	protein histidine kinase activity
D3869_22990	COG0154	amidase activity
D3869_23000	COG2351	hydroxyisourate hydrolase activity
D3869_23010	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_23015	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3869_23020	COG3842	ATPase activity
D3869_23045	COG0154	amidase activity
D3869_23065	COG0402	S-adenosylhomocysteine deaminase activity
D3869_23070	COG1116	anion transmembrane transporter activity
D3869_23075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_23115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3869_23125	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D3869_23160	COG1192	Involved in chromosome partitioning
D3869_23170	COG1653	transport
D3869_23185	COG3842	ATPase activity
D3869_23200	COG0431	NADPH-dependent FMN reductase
D3869_23205	COG0840	transmembrane signaling receptor activity
D3869_23205	COG0840	transmembrane signaling receptor activity
D3869_23220	COG0411	ABC transporter
D3869_23230	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_23245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3869_23250	COG1473	amidohydrolase
D3869_23295	COG1971	Probably functions as a manganese efflux pump
D3869_23300	COG3290	protein histidine kinase activity
D3869_23300	COG0840	transmembrane signaling receptor activity
D3869_23325	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_23330	COG0366	Alpha amylase catalytic
D3869_23335	COG2388	GCN5-related N-acetyl-transferase
D3869_23355	COG1139	Iron-sulfur cluster binding protein
D3869_23360	COG0247	lactate metabolic process
D3869_23365	COG0277	FAD linked oxidase domain protein
D3869_23370	COG1620	l-lactate permease
D3869_23375	COG2186	Transcriptional regulator
D3869_23385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3869_23390	COG0542	response to heat
D3869_23395	COG1414	Transcriptional regulator
D3869_23400	COG3734	2-keto-3-deoxy-galactonokinase
D3869_23405	COG0800	Aldolase
D3869_23430	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_23455	COG2205	protein histidine kinase activity
D3869_23455	COG5002	protein histidine kinase activity
D3869_23455	COG0784	Response regulator, receiver
D3869_23465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_23490	COG0840	transmembrane signaling receptor activity
D3869_23510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3869_23515	COG4191	Histidine kinase
D3869_23520	COG4566	intracellular signal transduction
D3869_23530	COG0848	biopolymer transport protein
D3869_23570	COG3275	phosphorelay sensor kinase activity
D3869_23580	COG1966	Carbon starvation protein
D3869_23590	COG1363	Peptidase, m42
D3869_23595	COG2918	glutathione biosynthetic process
D3869_23595	COG0189	ligase activity
D3869_23595	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3869_23600	COG0367	asparagine synthase
D3869_23640	COG1802	Transcriptional regulator
D3869_23645	COG2239	Acts as a magnesium transporter
D3869_23655	COG0861	Integral membrane protein TerC family
D3869_23725	COG2226	methyltransferase
D3869_23745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_23760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D3869_23765	COG1846	Transcriptional regulator
D3869_23775	COG1309	transcriptional regulator
D3869_23780	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_23785	COG2186	Transcriptional regulator
D3869_23790	COG1960	acyl-CoA dehydrogenase activity
D3869_23800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3869_23815	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_23835	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_23845	COG1960	acyl-CoA dehydrogenase activity
D3869_23855	COG0183	Belongs to the thiolase family
D3869_23860	COG1960	acyl-CoA dehydrogenase activity
D3869_23865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3869_23870	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D3869_23905	COG2819	hydrolase of the alpha beta superfamily
D3869_23925	COG2723	6-phospho-beta-galactosidase activity
D3869_23930	COG2723	6-phospho-beta-galactosidase activity
D3869_23935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3869_23945	COG4178	(ABC) transporter
D3869_23955	COG1442	glycosyl transferase family 8
D3869_23955	COG1216	Glycosyl transferase, family 2
D3869_23975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3869_23995	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3869_24010	COG2197	response regulator
D3869_24020	COG0643	Histidine kinase
D3869_24020	COG2198	Histidine kinase
D3869_24030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3869_24040	COG2201	protein-glutamate methylesterase activity
D3869_24045	COG0835	chemotaxis
D3869_24065	COG2095	MarC family integral membrane protein
D3869_24090	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_24095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3869_24110	COG0395	ABC-type sugar transport system, permease component
D3869_24135	COG0586	Pfam SNARE associated Golgi protein
D3869_24155	COG4615	Cyclic peptide transporter
D3869_24190	COG0840	transmembrane signaling receptor activity
D3869_24190	COG3290	protein histidine kinase activity
D3869_24220	COG5002	protein histidine kinase activity
D3869_24220	COG0784	Response regulator, receiver
D3869_24225	COG4191	Histidine kinase
D3869_24225	COG0784	Response regulator, receiver
D3869_24275	COG0668	transmembrane transport
D3869_24355	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3869_24360	COG1960	acyl-CoA dehydrogenase activity
D3869_24365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3869_24370	COG1764	response to oxidative stress
D3869_24390	COG0457	Tetratricopeptide repeat
D3869_24400	COG3842	ATPase activity
D3869_24415	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_24440	COG0583	DNA-binding transcription factor activity
D3869_24465	COG1573	uracil-dna glycosylase
D3869_24490	COG2010	Cytochrome c
D3869_24550	COG1131	(ABC) transporter
D3869_24570	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
D3869_24575	COG1229	Formylmethanofuran dehydrogenase subunit A
D3869_24585	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3869_24595	COG0702	epimerase
D3869_24610	COG0189	ligase activity
D3869_24620	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
D3869_24695	COG4566	intracellular signal transduction
D3869_24700	COG4191	Histidine kinase
D3869_24710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3869_24745	COG0411	ABC transporter
D3869_24750	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_24780	COG0183	Belongs to the thiolase family
D3869_24795	COG0410	ABC transporter
D3869_24805	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_24815	COG0683	leucine binding
D3869_24825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3869_24830	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3869_24830	COG0022	dehydrogenase e1 component
D3869_24835	COG1024	Enoyl-CoA hydratase
D3869_24865	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D3869_24870	COG1595	DNA-templated transcription, initiation
D3869_24885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_24890	COG1136	(ABC) transporter
D3869_24890	COG0577	efflux transmembrane transporter activity
D3869_24905	COG1121	(ABC) transporter
D3869_24965	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_24970	COG4948	Mandelate Racemase Muconate Lactonizing
D3869_24975	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D3869_24980	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_24985	COG1802	Transcriptional regulator
D3869_25025	COG5564	TIM-barrel signal transduction protein
D3869_25030	COG5441	Belongs to the UPF0261 family
D3869_25035	COG5564	TIM-barrel signal transduction protein
D3869_25035	COG2204	response regulator
D3869_25055	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3869_25060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3869_25080	COG0406	alpha-ribazole phosphatase activity
D3869_25080	COG0328	RNA-DNA hybrid ribonuclease activity
D3869_25095	COG1032	radical SAM domain protein
D3869_25130	COG3609	addiction module antidote protein, CC2985 family
D3869_25135	COG2205	protein histidine kinase activity
D3869_25135	COG0784	Response regulator, receiver
D3869_25155	COG2223	nitrite transmembrane transporter activity
D3869_25205	COG0489	protein tyrosine kinase activity
D3869_25215	COG4964	Belongs to the GSP D family
D3869_25270	COG3436	PFAM IS66 Orf2 family protein
D3869_25275	COG4372	Transposase
D3869_25320	COG1024	Enoyl-CoA hydratase
D3869_25330	COG3842	ATPase activity
D3869_25335	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_25340	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_25345	COG0840	transmembrane signaling receptor activity
D3869_25355	COG0427	acetyl-CoA hydrolase
D3869_25385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_25440	COG0840	transmembrane signaling receptor activity
D3869_25445	COG4178	(ABC) transporter
D3869_25455	COG1475	DNA binding
D3869_25460	COG1192	Involved in chromosome partitioning
D3869_25465	COG4783	chaperone-mediated protein folding
D3869_25485	COG3622	Belongs to the hyi family
D3869_25505	COG1215	transferase activity, transferring glycosyl groups
D3869_25520	COG3307	-O-antigen
D3869_25525	COG3206	protein involved in exopolysaccharide biosynthesis
D3869_25525	COG0489	protein tyrosine kinase activity
D3869_25555	COG1216	Glycosyl transferase, family 2
D3869_25630	COG4566	intracellular signal transduction
D3869_25645	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_25655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3869_25665	COG1994	Peptidase M50
D3869_25665	COG0517	IMP dehydrogenase activity
D3869_25680	COG1522	sequence-specific DNA binding
D3869_25690	COG0583	DNA-binding transcription factor activity
D3869_25700	COG2271	Major facilitator Superfamily
D3869_25705	COG1802	Transcriptional regulator
D3869_25710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_25720	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_25725	COG2354	Protein conserved in bacteria
D3869_25740	COG1309	transcriptional regulator
D3869_25755	COG1418	mRNA catabolic process
D3869_25760	COG1131	(ABC) transporter
D3869_25765	COG0842	Transport permease protein
D3869_25770	COG3791	Glutathione-dependent formaldehyde-activating
D3869_25775	COG0154	amidase activity
D3869_25780	COG0154	amidase activity
D3869_25780	COG0154	amidase activity
D3869_25815	COG1414	Transcriptional regulator
D3869_25820	COG0280	phosphate acetyltransferase
D3869_25840	COG1012	belongs to the aldehyde dehydrogenase family
D3869_25850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D3869_25855	COG0243	molybdopterin cofactor binding
D3869_25860	COG0437	4 iron, 4 sulfur cluster binding
D3869_25875	COG0028	Belongs to the TPP enzyme family
D3869_25880	COG1475	DNA binding
D3869_25885	COG1192	Involved in chromosome partitioning
D3869_25905	COG0546	phosphoglycolate phosphatase activity
D3869_25920	COG2855	membrane
D3869_25960	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D3869_25965	COG0784	Response regulator, receiver
D3869_25965	COG4191	Histidine kinase
D3869_25990	COG1012	belongs to the aldehyde dehydrogenase family
D3869_25995	COG0028	Belongs to the TPP enzyme family
D3869_26000	COG0583	DNA-binding transcription factor activity
D3869_26010	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_26015	COG0583	DNA-binding transcription factor activity
D3869_26020	COG0793	Belongs to the peptidase S41A family
D3869_26025	COG5487	UPF0391 membrane protein
D3869_26035	COG4191	Histidine kinase
D3869_26045	COG0028	Belongs to the TPP enzyme family
D3869_26055	COG1522	sequence-specific DNA binding
D3869_26075	COG3300	MHYT domain
D3869_26075	COG5001	Diguanylate cyclase
D3869_26090	COG2204	response regulator
D3869_26100	COG2985	domain, Protein
D3869_26115	COG3842	ATPase activity
D3869_26125	COG0588	phosphoglycerate mutase activity
D3869_26140	COG1454	alcohol dehydrogenase
D3869_26140	COG1012	belongs to the aldehyde dehydrogenase family
D3869_26225	COG1360	Flagellar Motor Protein
D3869_26230	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3869_26240	COG4786	Flagellar basal body rod
D3869_26245	COG4786	Flagellar basal body rod
D3869_26250	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
D3869_26255	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D3869_26275	COG0243	molybdopterin cofactor binding
D3869_26285	COG3005	denitrification pathway
D3869_26360	COG1766	The M ring may be actively involved in energy transduction
D3869_26370	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3869_26375	COG1338	Plays a role in the flagellum-specific transport system
D3869_26385	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3869_26425	COG3416	Protein conserved in bacteria
D3869_26430	COG0628	permease
D3869_26440	COG1597	lipid kinase activity
D3869_26445	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_26450	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D3869_26455	COG1802	Transcriptional regulator
D3869_26475	COG0668	transmembrane transport
D3869_26530	COG0596	Alpha beta hydrolase
D3869_26530	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3869_26530	COG2226	methyltransferase
D3869_26535	COG0183	Belongs to the thiolase family
D3869_26540	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_26570	COG2814	Major facilitator Superfamily
D3869_26575	COG0583	DNA-binding transcription factor activity
D3869_26585	COG5001	Diguanylate cyclase
D3869_26585	COG3300	MHYT domain
D3869_26590	COG0012	GTP binding
D3869_26610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3869_26610	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3869_26660	COG3772	lysozyme
D3869_26740	COG0740	serine-type endopeptidase activity
D3869_26770	COG0250	Participates in transcription elongation, termination and antitermination
D3869_26795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3869_26795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3869_26795	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3869_26880	COG4974	Belongs to the 'phage' integrase family
D3869_26890	COG2267	carboxylic ester hydrolase activity
D3869_26895	COG1131	(ABC) transporter
D3869_26925	COG3383	formate dehydrogenase (NAD+) activity
D3869_26930	COG1414	Transcriptional regulator
D3869_26955	COG4191	Histidine kinase
D3869_26960	COG0402	S-adenosylhomocysteine deaminase activity
D3869_26970	COG4603	Belongs to the binding-protein-dependent transport system permease family
D3869_26985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3869_27010	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3869_27065	COG2133	pyrroloquinoline quinone binding
D3869_27080	COG0583	DNA-binding transcription factor activity
D3869_27090	COG1733	regulation of RNA biosynthetic process
D3869_27095	COG0702	epimerase
D3869_27110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3869_27115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_27120	COG1309	transcriptional regulator
D3869_27130	COG2132	Multicopper oxidase
D3869_27135	COG5039	Polysaccharide pyruvyl transferase
D3869_27150	COG0725	ABC transporter, periplasmic molybdate-binding protein
D3869_27155	COG0246	Mannitol dehydrogenase
D3869_27175	COG2011	ABC-type metal ion transport system permease component
D3869_27180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D3869_27185	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_27225	COG1254	Belongs to the acylphosphatase family
D3869_27250	COG2239	Acts as a magnesium transporter
D3869_27255	COG2022	thiamine diphosphate biosynthetic process
D3869_27255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3869_27270	COG2022	thiamine diphosphate biosynthetic process
D3869_27325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3869_27335	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D3869_27345	COG0191	fructose-bisphosphate aldolase activity
D3869_27380	COG0861	Integral membrane protein TerC family
D3869_27415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3869_27415	COG2205	protein histidine kinase activity
D3869_27430	COG2721	sulfolactate sulfo-lyase activity
D3869_27435	COG1904	glucuronate isomerase
D3869_27440	COG1803	Methylglyoxal synthase
D3869_27445	COG1802	Transcriptional regulator
D3869_27450	COG0667	Aldo Keto reductase
D3869_27455	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_27465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_27470	COG1917	Cupin 2, conserved barrel domain protein
D3869_27475	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_27480	COG1802	Transcriptional regulator
D3869_27485	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3869_27500	COG4214	carbohydrate transport
D3869_27540	COG1879	ABC-type sugar transport system periplasmic component
D3869_27545	COG1129	ABC transporter
D3869_27550	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3869_27555	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3869_27565	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D3869_27570	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3869_27600	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_27605	COG1278	Cold shock
D3869_27610	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D3869_27615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3869_27620	COG0574	Belongs to the PEP-utilizing enzyme family
D3869_27620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3869_27630	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D3869_27635	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3869_27640	COG4106	trans-aconitate 2-methyltransferase activity
D3869_27640	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3869_27650	COG0156	8-amino-7-oxononanoate synthase activity
D3869_27665	COG0564	pseudouridine synthase activity
D3869_27675	COG0484	heat shock protein binding
D3869_27720	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_27730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3869_27735	COG4608	Belongs to the ABC transporter superfamily
D3869_27750	COG0601	transmembrane transport
D3869_27755	COG0747	negative chemotaxis
D3869_27765	COG2233	PERMEase
D3869_27770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3869_27775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3869_27785	COG1178	ABC-type Fe3 transport system permease component
D3869_27790	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_27795	COG3842	ATPase activity
D3869_27810	COG1045	serine acetyltransferase
D3869_27820	COG1595	DNA-templated transcription, initiation
D3869_27840	COG4191	Histidine kinase
D3869_27865	COG0784	Response regulator, receiver
D3869_27870	COG4251	negative regulation of phosphorylation
D3869_27890	COG4166	transmembrane transport
D3869_27905	COG0798	PFAM Bile acid sodium symporter
D3869_27920	COG2188	Transcriptional regulator
D3869_27935	COG0154	amidase activity
D3869_27950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_27955	COG1960	acyl-CoA dehydrogenase activity
D3869_27960	COG2079	MmgE PrpD family protein
D3869_27980	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_27985	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_28000	COG1595	DNA-templated transcription, initiation
D3869_28030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3869_28075	COG1132	(ABC) transporter
D3869_28090	COG2199	diguanylate cyclase activity
D3869_28090	COG2203	Gaf domain
D3869_28110	COG0405	Gamma-glutamyltransferase
D3869_28140	COG1858	cytochrome C peroxidase
D3869_28160	COG4964	Belongs to the GSP D family
D3869_28270	COG1312	Catalyzes the dehydration of D-mannonate
D3869_28275	COG0246	Mannitol dehydrogenase
D3869_28300	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3869_28310	COG0148	phosphopyruvate hydratase activity
D3869_28315	COG1882	Formate acetyltransferase
D3869_28320	COG1737	Transcriptional regulator
D3869_28320	COG0837	glucose binding
D3869_28325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3869_28330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_28335	COG1309	transcriptional regulator
D3869_28340	COG1309	transcriptional regulator
D3869_28350	COG4251	negative regulation of phosphorylation
D3869_28355	COG0469	pyruvate kinase activity
D3869_28360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3869_28365	COG2116	formate transmembrane transporter activity
D3869_28370	COG0697	spore germination
D3869_28375	COG1802	Transcriptional regulator
D3869_28380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_28390	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D3869_28395	COG0861	Integral membrane protein TerC family
D3869_28400	COG0840	transmembrane signaling receptor activity
D3869_28430	COG1256	bacterial-type flagellum assembly
D3869_28440	COG1706	bacterial-type flagellum-dependent cell motility
D3869_28465	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3869_28470	COG1684	flagellar biosynthetic protein fliR
D3869_28475	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3869_28485	COG4794	Type iii secretion
D3869_28490	COG1677	Flagellar hook-basal body complex protein FliE
D3869_28495	COG1558	bacterial-type flagellum-dependent cell motility
D3869_28500	COG1815	bacterial-type flagellum-dependent cell motility
D3869_28505	COG1157	protein secretion by the type III secretion system
D3869_28520	COG2814	Major facilitator Superfamily
D3869_28540	COG5443	negative regulation of bacterial-type flagellum assembly
D3869_28550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3869_28555	COG0745	RESPONSE REGULATOR receiver
D3869_28575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3869_28580	COG1802	Transcriptional regulator
D3869_28595	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3869_28600	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D3869_28605	COG1120	ATPase activity
D3869_28625	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D3869_28635	COG1845	cytochrome c oxidase, subunit III
D3869_28640	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_28660	COG0567	Dehydrogenase, E1 component
D3869_28665	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D3869_28680	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D3869_28690	COG0277	FAD linked oxidase domain protein
D3869_28695	COG2086	electron transfer activity
D3869_28720	COG0154	amidase activity
D3869_28745	COG0411	ABC transporter
D3869_28755	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_28775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3869_28790	COG0683	leucine binding
D3869_28795	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_28820	COG3473	Maleate cis-trans isomerase
D3869_28825	COG0596	Alpha beta hydrolase
D3869_28830	COG2309	aminopeptidase activity
D3869_28835	COG1335	isochorismatase
D3869_28845	COG1609	Transcriptional regulator
D3869_28850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3869_28850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3869_28855	COG1105	Belongs to the carbohydrate kinase PfkB family
D3869_28860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3869_28860	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D3869_28870	COG3920	Histidine kinase
D3869_28875	COG2197	response regulator
D3869_28905	COG0583	DNA-binding transcription factor activity
D3869_28920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3869_28940	COG0411	ABC transporter
D3869_28950	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3869_28965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3869_28970	COG0251	oxidation-reduction process
D3869_28975	COG1522	sequence-specific DNA binding
D3869_28980	COG1414	Transcriptional regulator
D3869_28985	COG1414	Transcriptional regulator
D3869_28990	COG0280	phosphate acetyltransferase
D3869_29010	COG1012	belongs to the aldehyde dehydrogenase family
D3869_29020	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D3869_29055	COG2814	Major facilitator Superfamily
D3869_29070	COG1609	Transcriptional regulator
D3869_29075	COG3608	succinylglutamate desuccinylase aspartoacylase
D3869_29080	COG0251	oxidation-reduction process
D3869_29095	COG4597	amino acid ABC transporter
D3869_29100	COG0765	amino acid transport
D3869_29155	COG2610	gluconate transmembrane transporter activity
D3869_29175	COG0583	DNA-binding transcription factor activity
D3869_29180	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_29185	COG3959	Transketolase, thiamine diphosphate binding domain
D3869_29190	COG3958	Transketolase
D3869_29195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_29205	COG2084	Dehydrogenase
D3869_29210	COG4221	oxidoreductase activity
D3869_29230	COG0747	negative chemotaxis
D3869_29250	COG0251	oxidation-reduction process
D3869_29265	COG2175	clavaminate synthase activity
D3869_29270	COG1116	anion transmembrane transporter activity
D3869_29275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_29285	COG2175	clavaminate synthase activity
D3869_29295	COG4521	taurine ABC transporter
D3869_29300	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D3869_29305	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_29310	COG3119	arylsulfatase activity
D3869_29315	COG2175	clavaminate synthase activity
D3869_29325	COG0784	Response regulator, receiver
D3869_29325	COG4191	Histidine kinase
D3869_29340	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_29345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3869_29350	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D3869_29360	COG1252	NADH dehydrogenase
D3869_29375	COG0583	DNA-binding transcription factor activity
D3869_29385	COG3220	belongs to the UPF0276 family
D3869_29405	COG1024	Enoyl-CoA hydratase
D3869_29420	COG0477	Major facilitator Superfamily
D3869_29440	COG0058	SHG alpha-glucan phosphorylase activity
D3869_29445	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D3869_29505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3869_29535	COG0683	leucine binding
D3869_29575	COG0644	oxidoreductase
D3869_29605	COG1881	PFAM PEBP family protein
D3869_29630	COG0024	Methionine aminopeptidase
D3869_29650	COG0601	transmembrane transport
D3869_29660	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D3869_29675	COG0444	Belongs to the ABC transporter superfamily
D3869_29690	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
D3869_29695	COG4221	oxidoreductase activity
D3869_29725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3869_29730	COG1063	alcohol dehydrogenase
D3869_29735	COG4948	Mandelate Racemase Muconate Lactonizing
D3869_29740	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_29765	COG0583	DNA-binding transcription factor activity
D3869_29775	COG0604	alcohol dehydrogenase
D3869_29780	COG1309	transcriptional regulator
D3869_29795	COG3842	ATPase activity
D3869_29805	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_29815	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_29820	COG1024	Enoyl-CoA hydratase
D3869_29835	COG2814	Major facilitator Superfamily
D3869_29860	COG3177	Filamentation induced by cAMP protein fic
D3869_29865	COG3415	Transposase
D3869_29870	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_29905	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3869_29985	COG1846	Transcriptional regulator
D3869_29990	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_30000	COG0583	DNA-binding transcription factor activity
D3869_30020	COG0601	transmembrane transport
D3869_30030	COG0444	Belongs to the ABC transporter superfamily
D3869_30040	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_30055	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D3869_30060	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3869_30060	COG1902	pentaerythritol trinitrate reductase activity
D3869_30095	COG3436	PFAM IS66 Orf2 family protein
D3869_30100	COG4372	Transposase
D3869_30130	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D3869_30150	COG0583	DNA-binding transcription factor activity
D3869_30160	COG1012	belongs to the aldehyde dehydrogenase family
D3869_30165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_30175	COG0477	Major facilitator Superfamily
D3869_30180	COG0583	DNA-binding transcription factor activity
D3869_30185	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_30195	COG0183	Belongs to the thiolase family
D3869_30200	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_30205	COG1024	Enoyl-CoA hydratase
D3869_30220	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_30225	COG0583	DNA-binding transcription factor activity
D3869_30230	COG1846	Transcriptional regulator
D3869_30235	COG1764	response to oxidative stress
D3869_30260	COG4977	sequence-specific DNA binding
D3869_30285	COG0523	cobalamin synthesis protein
D3869_30315	COG0583	DNA-binding transcription factor activity
D3869_30320	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_30380	COG1192	Involved in chromosome partitioning
D3869_30385	COG1475	DNA binding
D3869_30395	COG0667	Aldo Keto reductase
D3869_30405	COG0318	PFAM AMP-dependent synthetase and ligase
D3869_30425	COG1012	belongs to the aldehyde dehydrogenase family
D3869_30430	COG1024	Enoyl-CoA hydratase
D3869_30435	COG2186	Transcriptional regulator
D3869_30440	COG0747	negative chemotaxis
D3869_30445	COG2205	protein histidine kinase activity
D3869_30445	COG5002	protein histidine kinase activity
D3869_30445	COG0784	Response regulator, receiver
D3869_30450	COG2201	protein-glutamate methylesterase activity
D3869_30475	COG4774	siderophore transport
D3869_30485	COG1595	DNA-templated transcription, initiation
D3869_30515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3869_30525	COG1126	abc transporter atp-binding protein
D3869_30535	COG1070	Carbohydrate kinase
D3869_30540	COG2115	Belongs to the xylose isomerase family
D3869_30545	COG0673	inositol 2-dehydrogenase activity
D3869_30555	COG1879	ABC-type sugar transport system periplasmic component
D3869_30560	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3869_30570	COG1940	carbohydrate kinase activity
D3869_30575	COG0251	oxidation-reduction process
D3869_30580	COG0583	DNA-binding transcription factor activity
D3869_30625	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3869_30630	COG0402	S-adenosylhomocysteine deaminase activity
D3869_30645	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3869_30655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_30665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3869_30670	COG1129	ABC transporter
D3869_30670	COG0842	Transport permease protein
D3869_30675	COG0842	Transport permease protein
D3869_30695	COG0745	RESPONSE REGULATOR receiver
D3869_30700	COG1120	ATPase activity
D3869_30705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3869_30715	COG3720	iron ion transport
D3869_30720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3869_30725	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3869_30740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_30750	COG0583	DNA-binding transcription factor activity
D3869_30760	COG1017	nitric oxide dioxygenase activity
D3869_30760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3869_30765	COG0625	glutathione transferase activity
D3869_30770	COG1802	Transcriptional regulator
D3869_30815	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3869_30820	COG3842	ATPase activity
D3869_30825	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_30830	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_30835	COG3938	Belongs to the proline racemase family
D3869_30840	COG1802	Transcriptional regulator
D3869_30845	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D3869_30850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3869_30855	COG0066	3-isopropylmalate dehydratase activity
D3869_30870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_30930	COG3842	ATPase activity
D3869_30935	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D3869_30940	COG1349	DNA-binding transcription factor activity
D3869_30955	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_30970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_30980	COG1024	Enoyl-CoA hydratase
D3869_30985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3869_30990	COG0154	amidase activity
D3869_31000	COG2188	Transcriptional regulator
D3869_31005	COG3395	kinase activity
D3869_31010	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D3869_31015	COG1454	alcohol dehydrogenase
D3869_31020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3869_31035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_31045	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_31065	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3869_31070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3869_31075	COG0697	spore germination
D3869_31090	COG2188	Transcriptional regulator
D3869_31115	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D3869_31155	COG0765	amino acid transport
D3869_31190	COG0840	transmembrane signaling receptor activity
D3869_31230	COG2814	Major facilitator Superfamily
D3869_31245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3869_31250	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_31255	COG3842	ATPase activity
D3869_31265	COG0277	FAD linked oxidase domain protein
D3869_31285	COG0747	negative chemotaxis
D3869_31295	COG0601	transmembrane transport
D3869_31300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3869_31305	COG0444	Belongs to the ABC transporter superfamily
D3869_31310	COG4608	Belongs to the ABC transporter superfamily
D3869_31315	COG0697	spore germination
D3869_31320	COG1982	Orn Lys Arg decarboxylase major
D3869_31325	COG0583	DNA-binding transcription factor activity
D3869_31330	COG1335	isochorismatase
D3869_31340	COG1396	sequence-specific DNA binding
D3869_31340	COG1917	Cupin 2, conserved barrel domain protein
D3869_31355	COG1053	succinate dehydrogenase
D3869_31375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3869_31380	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D3869_31395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3869_31400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_31405	COG1396	sequence-specific DNA binding
D3869_31415	COG3256	nitric oxide reductase
D3869_31420	COG0714	Associated with various cellular activities
D3869_31440	COG4263	nitrous-oxide reductase activity
D3869_31455	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D3869_31470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3869_31510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3869_31520	COG1132	(ABC) transporter
D3869_31535	COG1120	ATPase activity
D3869_31540	COG4774	siderophore transport
D3869_31550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_31580	COG0583	DNA-binding transcription factor activity
D3869_31585	COG2271	Major facilitator Superfamily
D3869_31605	COG1120	ATPase activity
D3869_31625	COG4774	siderophore transport
D3869_31640	COG4774	siderophore transport
D3869_31645	COG1595	DNA-templated transcription, initiation
D3869_31655	COG0583	DNA-binding transcription factor activity
D3869_31670	COG2124	cytochrome p450
D3869_31675	COG0633	Ferredoxin
D3869_31705	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3869_31710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D3869_31720	COG2814	Major facilitator Superfamily
D3869_31730	COG0683	leucine binding
D3869_31745	COG0411	ABC transporter
D3869_31760	COG4566	intracellular signal transduction
D3869_31760	COG0745	RESPONSE REGULATOR receiver
D3869_31770	COG1278	Cold shock
D3869_31775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3869_31780	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3869_31800	COG2204	response regulator
D3869_31805	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3869_31810	COG3246	L-lysine catabolic process to acetate
D3869_31815	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_31830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3869_31840	COG0583	DNA-binding transcription factor activity
D3869_31850	COG1028	Short-chain dehydrogenase reductase Sdr
D3869_31860	COG1396	sequence-specific DNA binding
D3869_31865	COG0277	FAD linked oxidase domain protein
D3869_31870	COG1304	FMN binding
D3869_31885	COG0765	amino acid transport
D3869_31905	COG3842	ATPase activity
D3869_31910	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3869_31915	COG1177	transmembrane transport
D3869_31935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3869_31940	COG0251	oxidation-reduction process
D3869_31950	COG0251	oxidation-reduction process
D3869_31955	COG0861	Integral membrane protein TerC family
D3869_31975	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D3869_31995	COG2814	Major facilitator Superfamily
D3869_32010	COG1609	Transcriptional regulator
D3869_32015	COG3608	succinylglutamate desuccinylase aspartoacylase
D3869_32020	COG0251	oxidation-reduction process
D3869_32075	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3869_32105	COG2089	acid synthase
D3869_32145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D3869_32150	COG2226	methyltransferase
D3869_32155	COG0367	asparagine synthase
D3869_32165	COG0463	Glycosyl transferase, family 2
D3869_32190	COG0438	transferase activity, transferring glycosyl groups
D3869_32195	COG0500	methyltransferase
D3869_32200	COG0579	oxidoreductase
D3869_32220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D3869_32230	COG1215	transferase activity, transferring glycosyl groups
D3869_32240	COG0572	uridine kinase
D3869_32275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_32305	COG1091	dTDP-4-dehydrorhamnose reductase activity
D3869_32310	COG1088	dTDP-glucose 4,6-dehydratase activity
D3869_32315	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D3869_32320	COG0297	glycogen (starch) synthase activity
D3869_32370	COG1216	Glycosyl transferase, family 2
D3869_32370	COG0438	transferase activity, transferring glycosyl groups
D3869_32390	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3869_32475	COG0662	Cupin 2, conserved barrel domain protein
D3869_32475	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D3869_32480	COG0438	transferase activity, transferring glycosyl groups
D3869_32540	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3869_32555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D3869_32575	COG1192	Involved in chromosome partitioning
D3869_32580	COG1475	DNA binding
D3869_32590	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3869_32605	COG1086	Polysaccharide biosynthesis protein
D3869_32615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3869_32630	COG0494	nUDIX hydrolase
D3869_32650	COG0528	UMP kinase activity
D3869_32655	COG0528	UMP kinase activity
D3869_32680	COG1088	dTDP-glucose 4,6-dehydratase activity
D3869_32715	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D3869_32725	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3869_32740	COG2089	acid synthase