locus-tag	class	description
E6C67_00010	COG0683	leucine binding
E6C67_00015	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E6C67_00020	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E6C67_00025	COG0183	Belongs to the thiolase family
E6C67_00035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E6C67_00040	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E6C67_00050	COG3485	protocatechuate 3,4-dioxygenase
E6C67_00055	COG3485	protocatechuate 3,4-dioxygenase
E6C67_00065	COG0840	transmembrane signaling receptor activity
E6C67_00070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_00075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_00085	COG3265	gluconokinase activity
E6C67_00090	COG1609	Transcriptional regulator
E6C67_00095	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E6C67_00100	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E6C67_00110	COG0842	Transport permease protein
E6C67_00110	COG1129	ABC transporter
E6C67_00115	COG0842	Transport permease protein
E6C67_00125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E6C67_00135	COG0564	pseudouridine synthase activity
E6C67_00190	COG1566	PFAM secretion protein HlyD family protein
E6C67_00200	COG0129	dihydroxy-acid dehydratase activity
E6C67_00205	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E6C67_00205	COG1672	PFAM Archaeal ATPase
E6C67_00240	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_00245	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E6C67_00250	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E6C67_00255	COG2610	gluconate transmembrane transporter activity
E6C67_00260	COG2217	Heavy metal translocating P-type atpase
E6C67_00280	COG2884	Cell division ATP-binding protein ftsE
E6C67_00285	COG0204	Acyl-transferase
E6C67_00285	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_00335	COG2814	Major facilitator Superfamily
E6C67_00340	COG0667	Aldo Keto reductase
E6C67_00380	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
E6C67_00405	COG0588	phosphoglycerate mutase activity
E6C67_00410	COG0438	transferase activity, transferring glycosyl groups
E6C67_00425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C67_00430	COG0601	transmembrane transport
E6C67_00445	COG1132	(ABC) transporter
E6C67_00490	COG1960	acyl-CoA dehydrogenase activity
E6C67_00505	COG1192	Involved in chromosome partitioning
E6C67_00515	COG1902	pentaerythritol trinitrate reductase activity
E6C67_00520	COG3385	transposase activity
E6C67_00525	COG0667	Aldo Keto reductase
E6C67_00555	COG0454	-acetyltransferase
E6C67_00560	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E6C67_00565	COG0564	pseudouridine synthase activity
E6C67_00615	COG2972	Histidine kinase
E6C67_00615	COG0840	transmembrane signaling receptor activity
E6C67_00650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C67_00655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C67_00675	COG4774	siderophore transport
E6C67_00695	COG4585	Histidine kinase
E6C67_00750	COG0840	transmembrane signaling receptor activity
E6C67_00765	COG0411	ABC transporter
E6C67_00785	COG0686	Belongs to the AlaDH PNT family
E6C67_00795	COG1522	sequence-specific DNA binding
E6C67_00800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C67_00805	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E6C67_00815	COG3547	Transposase (IS116 IS110 IS902 family)
E6C67_00840	COG2205	protein histidine kinase activity
E6C67_00840	COG2198	Histidine kinase
E6C67_00840	COG0784	Response regulator, receiver
E6C67_00870	COG0306	phosphate transporter
E6C67_00880	COG2205	protein histidine kinase activity
E6C67_00880	COG2202	Pas domain
E6C67_00895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E6C67_00915	COG0587	DNA-directed DNA polymerase activity
E6C67_00940	COG0405	Gamma-glutamyltransferase
E6C67_00960	COG2204	response regulator
E6C67_00985	COG2814	Major facilitator Superfamily
E6C67_01000	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E6C67_01015	COG2084	Dehydrogenase
E6C67_01020	COG3622	Belongs to the hyi family
E6C67_01025	COG0446	pyridine nucleotide-disulphide oxidoreductase
E6C67_01025	COG1902	pentaerythritol trinitrate reductase activity
E6C67_01030	COG1802	Transcriptional regulator
E6C67_01035	COG0673	inositol 2-dehydrogenase activity
E6C67_01040	COG0861	Integral membrane protein TerC family
E6C67_01045	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_01055	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_01070	COG1309	transcriptional regulator
E6C67_01095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E6C67_01105	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_01110	COG1309	transcriptional regulator
E6C67_01115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E6C67_01125	COG2721	sulfolactate sulfo-lyase activity
E6C67_01130	COG1904	glucuronate isomerase
E6C67_01135	COG1802	Transcriptional regulator
E6C67_01140	COG1917	Cupin 2, conserved barrel domain protein
E6C67_01145	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_01150	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
E6C67_01155	COG1803	Methylglyoxal synthase
E6C67_01160	COG1802	Transcriptional regulator
E6C67_01190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_01195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_01200	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E6C67_01215	COG0183	Belongs to the thiolase family
E6C67_01220	COG2050	protein possibly involved in aromatic compounds catabolism
E6C67_01225	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_01230	COG1024	Enoyl-CoA hydratase
E6C67_01235	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_01240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E6C67_01245	COG2151	metal-sulfur cluster biosynthetic enzyme
E6C67_01250	COG3396	Phenylacetate-CoA oxygenase
E6C67_01255	COG3460	Phenylacetate-CoA oxygenase
E6C67_01260	COG3396	Phenylacetate-CoA oxygenase
E6C67_01270	COG0693	protein deglycase activity
E6C67_01275	COG2224	Isocitrate lyase
E6C67_01280	COG1396	sequence-specific DNA binding
E6C67_01280	COG3800	Transcriptional regulator
E6C67_01300	COG1280	lysine exporter protein (LysE YggA)
E6C67_01305	COG0784	Response regulator, receiver
E6C67_01305	COG3437	response regulator, receiver
E6C67_01310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E6C67_01320	COG1121	(ABC) transporter
E6C67_01325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E6C67_01345	COG0347	Belongs to the P(II) protein family
E6C67_01350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E6C67_01395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_01405	COG0784	Response regulator, receiver
E6C67_01405	COG2198	Histidine kinase
E6C67_01405	COG2205	protein histidine kinase activity
E6C67_01415	COG1764	response to oxidative stress
E6C67_01420	COG0019	diaminopimelate decarboxylase activity
E6C67_01435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C67_01440	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E6C67_01440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_01450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E6C67_01460	COG1131	(ABC) transporter
E6C67_01485	COG3206	protein involved in exopolysaccharide biosynthesis
E6C67_01485	COG0489	protein tyrosine kinase activity
E6C67_01495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E6C67_01510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C67_01525	COG0438	transferase activity, transferring glycosyl groups
E6C67_01530	COG1522	sequence-specific DNA binding
E6C67_01545	COG0628	permease
E6C67_01610	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E6C67_01620	COG3012	SEC-C Motif Domain Protein
E6C67_01625	COG1278	Cold shock
E6C67_01630	COG2205	protein histidine kinase activity
E6C67_01630	COG2202	Pas domain
E6C67_01650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E6C67_01665	COG0583	DNA-binding transcription factor activity
E6C67_01715	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_01775	COG2099	Precorrin-6x reductase
E6C67_01805	COG1797	cobyrinic acid a,c-diamide synthase activity
E6C67_01820	COG2198	Histidine kinase
E6C67_01820	COG0643	Histidine kinase
E6C67_01830	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E6C67_01840	COG2201	protein-glutamate methylesterase activity
E6C67_01845	COG0835	chemotaxis
E6C67_01850	COG0840	transmembrane signaling receptor activity
E6C67_01855	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C67_01855	COG1776	CheC inhibitor of MCP methylation
E6C67_01860	COG2201	protein-glutamate methylesterase activity
E6C67_01865	COG0859	PFAM glycosyl transferase family 9
E6C67_01865	COG0457	Tetratricopeptide repeat
E6C67_01870	COG1464	Belongs to the NlpA lipoprotein family
E6C67_01875	COG2011	ABC-type metal ion transport system permease component
E6C67_01880	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E6C67_01885	COG1464	Belongs to the NlpA lipoprotein family
E6C67_01900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E6C67_01910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E6C67_01935	COG1530	ribonuclease E activity
E6C67_01940	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E6C67_02060	COG1045	serine acetyltransferase
E6C67_02075	COG0287	Prephenate dehydrogenase
E6C67_02080	COG0583	DNA-binding transcription factor activity
E6C67_02085	COG0450	alkyl hydroperoxide reductase
E6C67_02095	COG1971	Probably functions as a manganese efflux pump
E6C67_02100	COG0402	S-adenosylhomocysteine deaminase activity
E6C67_02110	COG3385	transposase activity
E6C67_02115	COG1309	transcriptional regulator
E6C67_02120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_02125	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C67_02150	COG0784	Response regulator, receiver
E6C67_02160	COG3214	Protein conserved in bacteria
E6C67_02165	COG1522	sequence-specific DNA binding
E6C67_02170	COG0586	Pfam SNARE associated Golgi protein
E6C67_02185	COG0427	acetyl-CoA hydrolase
E6C67_02195	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E6C67_02200	COG2205	protein histidine kinase activity
E6C67_02200	COG2202	Pas domain
E6C67_02215	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_02220	COG2864	formate dehydrogenase
E6C67_02230	COG0437	4 iron, 4 sulfur cluster binding
E6C67_02235	COG0243	molybdopterin cofactor binding
E6C67_02235	COG3383	formate dehydrogenase (NAD+) activity
E6C67_02260	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E6C67_02280	COG4948	Mandelate Racemase Muconate Lactonizing
E6C67_02285	COG0583	DNA-binding transcription factor activity
E6C67_02305	COG1157	protein secretion by the type III secretion system
E6C67_02310	COG0745	RESPONSE REGULATOR receiver
E6C67_02315	COG1278	Cold shock
E6C67_02340	COG5002	protein histidine kinase activity
E6C67_02340	COG2198	Histidine kinase
E6C67_02340	COG0784	Response regulator, receiver
E6C67_02345	COG0835	chemotaxis
E6C67_02350	COG0643	Histidine kinase
E6C67_02350	COG2198	Histidine kinase
E6C67_02365	COG2205	protein histidine kinase activity
E6C67_02380	COG3920	Histidine kinase
E6C67_02385	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E6C67_02400	COG0531	amino acid
E6C67_02410	COG4303	Ethanolamine ammonia lyase large subunit
E6C67_02435	COG1280	lysine exporter protein (LysE YggA)
E6C67_02455	COG2723	6-phospho-beta-galactosidase activity
E6C67_02480	COG1295	ribonuclease BN
E6C67_02490	COG0861	Integral membrane protein TerC family
E6C67_02525	COG0793	Belongs to the peptidase S41A family
E6C67_02530	COG0736	holo-[acyl-carrier-protein] synthase activity
E6C67_02535	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E6C67_02540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E6C67_02545	COG0671	phosphoesterase, PA-phosphatase related
E6C67_02565	COG0848	biopolymer transport protein
E6C67_02580	COG4221	oxidoreductase activity
E6C67_02595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E6C67_02605	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
E6C67_02610	COG1595	DNA-templated transcription, initiation
E6C67_02615	COG3806	Anti-sigma factor
E6C67_02630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_02635	COG4597	amino acid ABC transporter
E6C67_02640	COG0765	amino acid transport
E6C67_02645	COG1126	abc transporter atp-binding protein
E6C67_02660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_02695	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_02700	COG3920	Histidine kinase
E6C67_02710	COG2203	Gaf domain
E6C67_02710	COG2199	diguanylate cyclase activity
E6C67_02715	COG0745	RESPONSE REGULATOR receiver
E6C67_02715	COG4566	intracellular signal transduction
E6C67_02725	COG1454	alcohol dehydrogenase
E6C67_02735	COG0183	Belongs to the thiolase family
E6C67_02740	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_02750	COG1309	transcriptional regulator
E6C67_02755	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_02760	COG1024	Enoyl-CoA hydratase
E6C67_02780	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_02795	COG0583	DNA-binding transcription factor activity
E6C67_02825	COG1674	ftsk spoiiie
E6C67_02885	COG1475	DNA binding
E6C67_02890	COG1192	Involved in chromosome partitioning
E6C67_02960	COG4962	Type ii secretion system protein e
E6C67_02975	COG3451	type IV secretory pathway VirB4
E6C67_02990	COG3846	protein secretion by the type IV secretion system
E6C67_02995	COG3701	Conjugal transfer protein
E6C67_03010	COG2948	multi-organism process
E6C67_03015	COG2135	peptidase activity
E6C67_03020	COG3177	Filamentation induced by cAMP protein fic
E6C67_03025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E6C67_03095	COG0586	Pfam SNARE associated Golgi protein
E6C67_03100	COG0671	phosphoesterase, PA-phosphatase related
E6C67_03105	COG0586	Pfam SNARE associated Golgi protein
E6C67_03110	COG5002	protein histidine kinase activity
E6C67_03120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_03130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_03140	COG2205	protein histidine kinase activity
E6C67_03150	COG2204	response regulator
E6C67_03210	COG2814	Major facilitator Superfamily
E6C67_03245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C67_03250	COG1086	Polysaccharide biosynthesis protein
E6C67_03265	COG0463	Glycosyl transferase, family 2
E6C67_03265	COG1216	Glycosyl transferase, family 2
E6C67_03285	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E6C67_03285	COG0662	Cupin 2, conserved barrel domain protein
E6C67_03310	COG2274	protein secretion by the type I secretion system
E6C67_03315	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_03330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C67_03335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E6C67_03345	COG1091	dTDP-4-dehydrorhamnose reductase activity
E6C67_03350	COG1088	dTDP-glucose 4,6-dehydratase activity
E6C67_03355	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
E6C67_03360	COG1216	Glycosyl transferase, family 2
E6C67_03360	COG0438	transferase activity, transferring glycosyl groups
E6C67_03365	COG1216	Glycosyl transferase, family 2
E6C67_03365	COG0438	transferase activity, transferring glycosyl groups
E6C67_03405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E6C67_03410	COG0438	transferase activity, transferring glycosyl groups
E6C67_03410	COG0297	glycogen (starch) synthase activity
E6C67_03415	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E6C67_03420	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E6C67_03430	COG0500	methyltransferase
E6C67_03435	COG1132	(ABC) transporter
E6C67_03460	COG0463	Glycosyl transferase, family 2
E6C67_03475	COG0463	Glycosyl transferase, family 2
E6C67_03505	COG0457	Tetratricopeptide repeat
E6C67_03505	COG0859	PFAM glycosyl transferase family 9
E6C67_03520	COG2274	protein secretion by the type I secretion system
E6C67_03550	COG0519	Catalyzes the synthesis of GMP from XMP
E6C67_03555	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C67_03565	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E6C67_03580	COG2089	acid synthase
E6C67_03600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C67_03620	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E6C67_03625	COG0107	imidazoleglycerol-phosphate synthase activity
E6C67_03640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C67_03665	COG0438	transferase activity, transferring glycosyl groups
E6C67_03760	COG1192	Involved in chromosome partitioning
E6C67_03765	COG1475	DNA binding
E6C67_03790	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
E6C67_03800	COG3504	Conjugal transfer protein
E6C67_03805	COG3736	Type IV secretory pathway, component VirB8
E6C67_03825	COG3451	type IV secretory pathway VirB4
E6C67_03830	COG3702	type iv secretory pathway
E6C67_03860	COG2885	chlorophyll binding
E6C67_03895	COG2885	chlorophyll binding
E6C67_03895	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E6C67_03925	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_03985	COG4106	trans-aconitate 2-methyltransferase activity
E6C67_03990	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C67_04020	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E6C67_04040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E6C67_04065	COG0789	Transcriptional regulator
E6C67_04070	COG0784	Response regulator, receiver
E6C67_04070	COG4191	Histidine kinase
E6C67_04075	COG1686	Belongs to the peptidase S11 family
E6C67_04085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E6C67_04095	COG2321	neutral zinc metallopeptidase
E6C67_04140	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E6C67_04145	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E6C67_04160	COG0175	sulfate reduction
E6C67_04235	COG1643	Atp-dependent helicase
E6C67_04265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E6C67_04290	COG3958	Transketolase
E6C67_04295	COG3959	Transketolase, thiamine diphosphate binding domain
E6C67_04305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C67_04315	COG1442	glycosyl transferase family 8
E6C67_04315	COG1216	Glycosyl transferase, family 2
E6C67_04320	COG2046	Belongs to the sulfate adenylyltransferase family
E6C67_04320	COG0529	Catalyzes the synthesis of activated sulfate
E6C67_04335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E6C67_04340	COG1213	nucleotidyl transferase
E6C67_04355	COG3848	Pyruvate phosphate dikinase
E6C67_04355	COG0574	Belongs to the PEP-utilizing enzyme family
E6C67_04370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E6C67_04415	COG4638	Rieske (2fe-2S)
E6C67_04500	COG4106	trans-aconitate 2-methyltransferase activity
E6C67_04510	COG0675	Transposase, IS605 OrfB family
E6C67_04525	COG1802	Transcriptional regulator
E6C67_04525	COG4626	Terminase
E6C67_04545	COG1129	ABC transporter
E6C67_04550	COG4214	carbohydrate transport
E6C67_04555	COG4213	ABC transporter substrate-binding protein
E6C67_04560	COG2115	Belongs to the xylose isomerase family
E6C67_04565	COG1070	Carbohydrate kinase
E6C67_04570	COG1609	Transcriptional regulator
E6C67_04595	COG2353	YceI-like domain
E6C67_04600	COG0435	Glutathione S-transferase
E6C67_04630	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_04655	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E6C67_04685	COG4263	nitrous-oxide reductase activity
E6C67_04695	COG4459	periplasmic nitrate reductase
E6C67_04705	COG3062	negative regulation of establishment of protein localization
E6C67_04720	COG3005	denitrification pathway
E6C67_04725	COG1475	DNA binding
E6C67_04730	COG1192	Involved in chromosome partitioning
E6C67_04735	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_04745	COG0840	transmembrane signaling receptor activity
E6C67_04755	COG3437	response regulator, receiver
E6C67_04760	COG1320	monovalent cation:proton antiporter activity
E6C67_04765	COG2212	antiporter activity
E6C67_04770	COG1863	multisubunit Na H antiporter MnhE subunit
E6C67_04775	COG0651	ATP synthesis coupled electron transport
E6C67_04780	COG1006	Multisubunit Na H antiporter MnhC subunit
E6C67_04785	COG2111	Na H antiporter
E6C67_04785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E6C67_04790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C67_04800	COG4191	Histidine kinase
E6C67_04805	COG4566	intracellular signal transduction
E6C67_04840	COG2814	Major facilitator Superfamily
E6C67_04870	COG2186	Transcriptional regulator
E6C67_04890	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C67_04895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_04900	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_04905	COG1960	acyl-CoA dehydrogenase activity
E6C67_04915	COG0183	Belongs to the thiolase family
E6C67_04940	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_04950	COG1032	radical SAM domain protein
E6C67_05000	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
E6C67_05015	COG0840	transmembrane signaling receptor activity
E6C67_05020	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_05025	COG3002	Belongs to the UPF0753 family
E6C67_05030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E6C67_05040	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_05045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E6C67_05050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_05055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E6C67_05070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_05105	COG0583	DNA-binding transcription factor activity
E6C67_05110	COG0747	negative chemotaxis
E6C67_05125	COG0444	Belongs to the ABC transporter superfamily
E6C67_05130	COG4608	Belongs to the ABC transporter superfamily
E6C67_05150	COG2515	1-aminocyclopropane-1-carboxylate deaminase
E6C67_05155	COG1522	sequence-specific DNA binding
E6C67_05165	COG0251	oxidation-reduction process
E6C67_05210	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E6C67_05220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_05255	COG0300	oxidoreductase activity
E6C67_05310	COG1960	acyl-CoA dehydrogenase activity
E6C67_05335	COG0444	Belongs to the ABC transporter superfamily
E6C67_05350	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E6C67_05360	COG0601	transmembrane transport
E6C67_05395	COG0411	ABC transporter
E6C67_05405	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_05420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_05425	COG1473	amidohydrolase
E6C67_05430	COG0457	Tetratricopeptide repeat
E6C67_05430	COG0859	PFAM glycosyl transferase family 9
E6C67_05455	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E6C67_05500	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_05505	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_05525	COG0471	metal ion transport
E6C67_05525	COG3273	potassium ion transport
E6C67_05530	COG0517	IMP dehydrogenase activity
E6C67_05540	COG0784	Response regulator, receiver
E6C67_05550	COG1758	RNA polymerase activity
E6C67_05555	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E6C67_05580	COG1914	H( )-stimulated, divalent metal cation uptake system
E6C67_05585	COG1321	iron dependent repressor
E6C67_05595	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E6C67_05595	COG1918	ferrous iron import across plasma membrane
E6C67_05605	COG2814	Major facilitator Superfamily
E6C67_05620	COG0840	transmembrane signaling receptor activity
E6C67_05625	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E6C67_05635	COG1063	alcohol dehydrogenase
E6C67_05640	COG0583	DNA-binding transcription factor activity
E6C67_05655	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E6C67_05700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E6C67_05770	COG1175	transmembrane transport
E6C67_05780	COG1940	carbohydrate kinase activity
E6C67_05785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C67_05790	COG0348	domain, Protein
E6C67_05850	COG0025	NhaP-type Na H and K H
E6C67_05865	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E6C67_05875	COG1335	isochorismatase
E6C67_05890	COG0673	inositol 2-dehydrogenase activity
E6C67_05900	COG1879	ABC-type sugar transport system periplasmic component
E6C67_05905	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C67_05910	COG1129	ABC transporter
E6C67_05915	COG1940	carbohydrate kinase activity
E6C67_05920	COG0840	transmembrane signaling receptor activity
E6C67_05940	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C67_05940	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C67_05945	COG1263	PTS System
E6C67_05945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E6C67_05950	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E6C67_05955	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E6C67_05960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C67_05970	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E6C67_05975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E6C67_05975	COG2190	(PTS) system
E6C67_05975	COG1263	PTS System
E6C67_05985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C67_05990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_05995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_06000	COG1116	anion transmembrane transporter activity
E6C67_06025	COG4191	Histidine kinase
E6C67_06030	COG1301	dicarboxylic acid transport
E6C67_06035	COG1027	Aspartate ammonia-lyase
E6C67_06040	COG2258	MOSC domain
E6C67_06045	COG3622	Belongs to the hyi family
E6C67_06055	COG0604	alcohol dehydrogenase
E6C67_06060	COG0583	DNA-binding transcription factor activity
E6C67_06070	COG4191	Histidine kinase
E6C67_06075	COG4566	intracellular signal transduction
E6C67_06085	COG2205	protein histidine kinase activity
E6C67_06085	COG0784	Response regulator, receiver
E6C67_06090	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E6C67_06100	COG4783	chaperone-mediated protein folding
E6C67_06105	COG0583	DNA-binding transcription factor activity
E6C67_06110	COG0667	Aldo Keto reductase
E6C67_06115	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_06120	COG4191	Histidine kinase
E6C67_06140	COG1982	Orn Lys Arg decarboxylase major
E6C67_06155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E6C67_06165	COG1802	Transcriptional regulator
E6C67_06175	COG2226	methyltransferase
E6C67_06180	COG1802	Transcriptional regulator
E6C67_06185	COG0179	Fumarylacetoacetate (FAA) hydrolase
E6C67_06195	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_06205	COG1937	Protein conserved in bacteria
E6C67_06215	COG3012	SEC-C Motif Domain Protein
E6C67_06225	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E6C67_06230	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_06235	COG1522	sequence-specific DNA binding
E6C67_06240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C67_06245	COG1126	abc transporter atp-binding protein
E6C67_06250	COG0765	amino acid transport
E6C67_06255	COG0765	amino acid transport
E6C67_06265	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E6C67_06270	COG2423	ornithine cyclodeaminase activity
E6C67_06275	COG0006	proline dipeptidase activity
E6C67_06280	COG3608	succinylglutamate desuccinylase aspartoacylase
E6C67_06290	COG0583	DNA-binding transcription factor activity
E6C67_06295	COG2828	Protein conserved in bacteria
E6C67_06300	COG1301	dicarboxylic acid transport
E6C67_06305	COG0745	RESPONSE REGULATOR receiver
E6C67_06320	COG0668	transmembrane transport
E6C67_06325	COG1760	l-serine dehydratase
E6C67_06330	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E6C67_06340	COG0446	pyridine nucleotide-disulphide oxidoreductase
E6C67_06340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E6C67_06385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C67_06405	COG0730	response to heat
E6C67_06410	COG4191	Histidine kinase
E6C67_06415	COG4566	intracellular signal transduction
E6C67_06420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E6C67_06450	COG0737	Belongs to the 5'-nucleotidase family
E6C67_06485	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_06490	COG0583	DNA-binding transcription factor activity
E6C67_06515	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_06520	COG1309	transcriptional regulator
E6C67_06525	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_06535	COG1414	Transcriptional regulator
E6C67_06540	COG1234	tRNA 3'-trailer cleavage
E6C67_06550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E6C67_06555	COG0066	3-isopropylmalate dehydratase activity
E6C67_06570	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_06585	COG0410	ABC transporter
E6C67_06590	COG0277	FAD linked oxidase domain protein
E6C67_06595	COG2226	methyltransferase
E6C67_06600	COG2814	Major facilitator Superfamily
E6C67_06610	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E6C67_06620	COG4221	oxidoreductase activity
E6C67_06640	COG0697	spore germination
E6C67_06645	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C67_06660	COG1295	ribonuclease BN
E6C67_06670	COG0583	DNA-binding transcription factor activity
E6C67_06675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E6C67_06680	COG0235	Class ii aldolase
E6C67_06695	COG0601	transmembrane transport
E6C67_06710	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E6C67_06760	COG3052	prosthetic group binding
E6C67_06780	COG1802	Transcriptional regulator
E6C67_06785	COG5001	Diguanylate cyclase
E6C67_06790	COG2116	formate transmembrane transporter activity
E6C67_06795	COG0148	phosphopyruvate hydratase activity
E6C67_06810	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E6C67_06820	COG0126	phosphoglycerate kinase activity
E6C67_06845	COG0583	DNA-binding transcription factor activity
E6C67_06850	COG0300	oxidoreductase activity
E6C67_06865	COG4566	intracellular signal transduction
E6C67_06875	COG2815	serine threonine protein kinase
E6C67_06875	COG0515	serine threonine protein kinase
E6C67_06885	COG4977	sequence-specific DNA binding
E6C67_06900	COG2855	membrane
E6C67_06925	COG1522	sequence-specific DNA binding
E6C67_06935	COG2706	6-phosphogluconolactonase activity
E6C67_06940	COG2721	sulfolactate sulfo-lyase activity
E6C67_06955	COG1312	Catalyzes the dehydration of D-mannonate
E6C67_06960	COG2271	Major facilitator Superfamily
E6C67_06965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E6C67_06970	COG2186	Transcriptional regulator
E6C67_06995	COG0431	NADPH-dependent FMN reductase
E6C67_06995	COG3976	FMN-binding domain protein
E6C67_06995	COG1053	succinate dehydrogenase
E6C67_07020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E6C67_07040	COG2205	protein histidine kinase activity
E6C67_07040	COG2198	Histidine kinase
E6C67_07040	COG0784	Response regulator, receiver
E6C67_07050	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C67_07060	COG4325	translation initiation factor activity
E6C67_07065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C67_07090	COG0437	4 iron, 4 sulfur cluster binding
E6C67_07125	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E6C67_07130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C67_07175	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
E6C67_07180	COG0702	epimerase
E6C67_07195	COG1229	Formylmethanofuran dehydrogenase subunit A
E6C67_07200	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
E6C67_07225	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
E6C67_07240	COG4067	protein conserved in archaea
E6C67_07240	COG0189	ligase activity
E6C67_07250	COG1131	(ABC) transporter
E6C67_07305	COG3383	formate dehydrogenase (NAD+) activity
E6C67_07315	COG0546	phosphoglycolate phosphatase activity
E6C67_07320	COG0191	fructose-bisphosphate aldolase activity
E6C67_07325	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E6C67_07330	COG3954	Phosphoribulokinase
E6C67_07335	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E6C67_07355	COG1850	ribulose-bisphosphate carboxylase activity
E6C67_07360	COG0583	DNA-binding transcription factor activity
E6C67_07365	COG1349	DNA-binding transcription factor activity
E6C67_07370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E6C67_07375	COG1879	ABC-type sugar transport system periplasmic component
E6C67_07380	COG1129	ABC transporter
E6C67_07385	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C67_07390	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C67_07400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E6C67_07405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E6C67_07420	COG2233	PERMEase
E6C67_07465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_07480	COG1609	Transcriptional regulator
E6C67_07485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_07490	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_07500	COG1850	ribulose-bisphosphate carboxylase activity
E6C67_07515	COG0251	oxidation-reduction process
E6C67_07525	COG0251	oxidation-reduction process
E6C67_07565	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_07570	COG1177	transmembrane transport
E6C67_07580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_07590	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E6C67_07600	COG0673	inositol 2-dehydrogenase activity
E6C67_07615	COG1309	transcriptional regulator
E6C67_07620	COG3387	PFAM Glycoside hydrolase 15-related
E6C67_07630	COG0277	FAD linked oxidase domain protein
E6C67_07630	COG0247	lactate metabolic process
E6C67_07635	COG4948	Mandelate Racemase Muconate Lactonizing
E6C67_07640	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_07640	COG1454	alcohol dehydrogenase
E6C67_07645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_07650	COG4566	intracellular signal transduction
E6C67_07655	COG4566	intracellular signal transduction
E6C67_07660	COG4191	Histidine kinase
E6C67_07675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E6C67_07720	COG1706	bacterial-type flagellum-dependent cell motility
E6C67_07730	COG1256	bacterial-type flagellum assembly
E6C67_07735	COG1749	Flagellar hook protein flgE
E6C67_07750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E6C67_07760	COG4786	Flagellar basal body rod
E6C67_07765	COG4786	Flagellar basal body rod
E6C67_07770	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E6C67_07775	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E6C67_07790	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E6C67_07820	COG1766	The M ring may be actively involved in energy transduction
E6C67_07830	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C67_07840	COG1338	Plays a role in the flagellum-specific transport system
E6C67_07850	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C67_07865	COG0745	RESPONSE REGULATOR receiver
E6C67_07870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E6C67_07875	COG5442	Flagellar protein FlaF
E6C67_07880	COG5443	negative regulation of bacterial-type flagellum assembly
E6C67_07895	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E6C67_07915	COG1157	protein secretion by the type III secretion system
E6C67_07925	COG1558	bacterial-type flagellum-dependent cell motility
E6C67_07930	COG1677	Flagellar hook-basal body complex protein FliE
E6C67_07945	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E6C67_07955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E6C67_07965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E6C67_07970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E6C67_07975	COG0351	phosphomethylpyrimidine kinase
E6C67_07980	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E6C67_07995	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E6C67_08000	COG1845	cytochrome c oxidase, subunit III
E6C67_08005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C67_08010	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E6C67_08015	COG0477	Major facilitator Superfamily
E6C67_08065	COG1988	membrane-bound metal-dependent
E6C67_08085	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E6C67_08175	COG3561	AntA/AntB antirepressor
E6C67_08255	COG3756	Protein conserved in bacteria
E6C67_08550	COG0675	Transposase, IS605 OrfB family
E6C67_08575	COG2814	Major facilitator Superfamily
E6C67_08590	COG4178	(ABC) transporter
E6C67_08600	COG0840	transmembrane signaling receptor activity
E6C67_08605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E6C67_08615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E6C67_08665	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_08670	COG0583	DNA-binding transcription factor activity
E6C67_08680	COG4993	Dehydrogenase
E6C67_08685	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_08695	COG2086	electron transfer activity
E6C67_08710	COG2723	6-phospho-beta-galactosidase activity
E6C67_08735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E6C67_08740	COG1127	ABC transporter
E6C67_08745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E6C67_08750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E6C67_08755	COG0305	Participates in initiation and elongation during chromosome replication
E6C67_08785	COG0598	Magnesium transport protein CorA
E6C67_08825	COG2184	nucleotidyltransferase activity
E6C67_08855	COG1484	DNA-dependent DNA replication
E6C67_08860	COG4584	PFAM Integrase catalytic
E6C67_08890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E6C67_08910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E6C67_08915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E6C67_08925	COG3218	ABC-type transport auxiliary lipoprotein component
E6C67_08925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E6C67_08955	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E6C67_08970	COG2703	oxygen carrier activity
E6C67_08985	COG0521	Mo-molybdopterin cofactor biosynthetic process
E6C67_08990	COG0741	lytic transglycosylase activity
E6C67_08995	COG1573	uracil-dna glycosylase
E6C67_09010	COG3283	Transcriptional regulator of aromatic amino acids metabolism
E6C67_09015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_09030	COG1139	Iron-sulfur cluster binding protein
E6C67_09035	COG0247	lactate metabolic process
E6C67_09045	COG1620	l-lactate permease
E6C67_09050	COG2186	Transcriptional regulator
E6C67_09055	COG2204	response regulator
E6C67_09070	COG0372	Belongs to the citrate synthase family
E6C67_09085	COG2205	protein histidine kinase activity
E6C67_09085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_09100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_09115	COG1737	Transcriptional regulator
E6C67_09130	COG3604	Transcriptional regulator
E6C67_09140	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_09145	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E6C67_09155	COG3829	transcription factor binding
E6C67_09155	COG3290	protein histidine kinase activity
E6C67_09165	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_09175	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_09180	COG1063	alcohol dehydrogenase
E6C67_09185	COG0246	Mannitol dehydrogenase
E6C67_09190	COG1802	Transcriptional regulator
E6C67_09195	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_09205	COG3842	ATPase activity
E6C67_09215	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E6C67_09235	COG0784	Response regulator, receiver
E6C67_09235	COG2205	protein histidine kinase activity
E6C67_09235	COG5002	protein histidine kinase activity
E6C67_09240	COG3437	response regulator, receiver
E6C67_09245	COG3416	Protein conserved in bacteria
E6C67_09255	COG3920	Histidine kinase
E6C67_09265	COG0300	oxidoreductase activity
E6C67_09270	COG5265	(ABC) transporter
E6C67_09275	COG3385	transposase activity
E6C67_09280	COG1032	radical SAM domain protein
E6C67_09310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E6C67_09320	COG0573	inorganic phosphate transmembrane transporter activity
E6C67_09325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E6C67_09335	COG0625	glutathione transferase activity
E6C67_09340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C67_09375	COG2814	Major facilitator Superfamily
E6C67_09390	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E6C67_09410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C67_09425	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E6C67_09425	COG2885	chlorophyll binding
E6C67_09460	COG0411	ABC transporter
E6C67_09480	COG1940	carbohydrate kinase activity
E6C67_09500	COG0463	Glycosyl transferase, family 2
E6C67_09520	COG4191	Histidine kinase
E6C67_09520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_09545	COG1858	cytochrome C peroxidase
E6C67_09560	COG4191	Histidine kinase
E6C67_09575	COG0840	transmembrane signaling receptor activity
E6C67_09590	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E6C67_09615	COG3842	ATPase activity
E6C67_09620	COG3842	ATPase activity
E6C67_09635	COG1349	DNA-binding transcription factor activity
E6C67_09690	COG0697	spore germination
E6C67_09700	COG0569	domain protein
E6C67_09705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E6C67_09750	COG1116	anion transmembrane transporter activity
E6C67_09755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_09760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C67_09765	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_09790	COG1032	radical SAM domain protein
E6C67_09795	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C67_09810	COG0406	alpha-ribazole phosphatase activity
E6C67_09830	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E6C67_09845	COG1648	precorrin-2 dehydrogenase activity
E6C67_09845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E6C67_09855	COG0243	molybdopterin cofactor binding
E6C67_09865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E6C67_09870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C67_09875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_09880	COG1116	anion transmembrane transporter activity
E6C67_09885	COG0656	L-ascorbic acid biosynthetic process
E6C67_09920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E6C67_09925	COG2017	converts alpha-aldose to the beta-anomer
E6C67_09930	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C67_09935	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C67_09940	COG1129	ABC transporter
E6C67_09950	COG1879	ABC-type sugar transport system periplasmic component
E6C67_09985	COG1129	ABC transporter
E6C67_09990	COG4214	carbohydrate transport
E6C67_10000	COG0840	transmembrane signaling receptor activity
E6C67_10005	COG0129	dihydroxy-acid dehydratase activity
E6C67_10025	COG1966	Carbon starvation protein
E6C67_10030	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_10055	COG1794	racemase activity, acting on amino acids and derivatives
E6C67_10060	COG3279	Response regulator of the LytR AlgR family
E6C67_10065	COG3275	phosphorelay sensor kinase activity
E6C67_10075	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_10085	COG0644	oxidoreductase
E6C67_10090	COG0583	DNA-binding transcription factor activity
E6C67_10100	COG1475	DNA binding
E6C67_10105	COG1192	Involved in chromosome partitioning
E6C67_10145	COG1686	Belongs to the peptidase S11 family
E6C67_10155	COG1609	Transcriptional regulator
E6C67_10160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E6C67_10165	COG1126	abc transporter atp-binding protein
E6C67_10170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_10175	COG0765	amino acid transport
E6C67_10180	COG0765	amino acid transport
E6C67_10185	COG2814	Major facilitator Superfamily
E6C67_10195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_10200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C67_10235	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E6C67_10250	COG0277	FAD linked oxidase domain protein
E6C67_10250	COG0247	lactate metabolic process
E6C67_10255	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E6C67_10260	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_10275	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_10285	COG0583	DNA-binding transcription factor activity
E6C67_10295	COG0747	negative chemotaxis
E6C67_10300	COG0601	transmembrane transport
E6C67_10350	COG0596	Alpha beta hydrolase
E6C67_10360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E6C67_10360	COG1042	CoA-binding domain protein
E6C67_10360	COG0045	succinate-CoA ligase (ADP-forming) activity
E6C67_10365	COG1960	acyl-CoA dehydrogenase activity
E6C67_10370	COG0583	DNA-binding transcription factor activity
E6C67_10375	COG0183	Belongs to the thiolase family
E6C67_10385	COG2086	electron transfer activity
E6C67_10390	COG0840	transmembrane signaling receptor activity
E6C67_10400	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_10415	COG0372	Belongs to the citrate synthase family
E6C67_10425	COG3976	FMN-binding domain protein
E6C67_10425	COG1053	succinate dehydrogenase
E6C67_10430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_10440	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_10445	COG1414	Transcriptional regulator
E6C67_10460	COG0583	DNA-binding transcription factor activity
E6C67_10470	COG0246	Mannitol dehydrogenase
E6C67_10475	COG1312	Catalyzes the dehydration of D-mannonate
E6C67_10480	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_10490	COG2814	Major facilitator Superfamily
E6C67_10500	COG4221	oxidoreductase activity
E6C67_10505	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_10515	COG0583	DNA-binding transcription factor activity
E6C67_10550	COG0513	Belongs to the DEAD box helicase family
E6C67_10570	COG0784	Response regulator, receiver
E6C67_10570	COG4191	Histidine kinase
E6C67_10635	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_10645	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E6C67_10670	COG2207	Transcriptional regulator
E6C67_10695	COG0523	cobalamin synthesis protein
E6C67_10745	COG0655	NAD(P)H dehydrogenase (quinone) activity
E6C67_10750	COG0583	DNA-binding transcription factor activity
E6C67_10765	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E6C67_10775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_10795	COG0587	DNA-directed DNA polymerase activity
E6C67_10805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C67_10810	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E6C67_10825	COG1522	sequence-specific DNA binding
E6C67_10835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E6C67_10860	COG1396	sequence-specific DNA binding
E6C67_10890	COG1484	DNA-dependent DNA replication
E6C67_10895	COG4584	PFAM Integrase catalytic
E6C67_10925	COG1396	sequence-specific DNA binding
E6C67_10930	COG3550	peptidyl-serine autophosphorylation
E6C67_10970	COG3547	Transposase (IS116 IS110 IS902 family)
E6C67_10975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_11005	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E6C67_11010	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E6C67_11015	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
E6C67_11020	COG2205	protein histidine kinase activity
E6C67_11025	COG0745	RESPONSE REGULATOR receiver
E6C67_11075	COG3093	addiction module antidote protein HigA
E6C67_11135	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_11145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E6C67_11155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E6C67_11165	COG4584	PFAM Integrase catalytic
E6C67_11170	COG1484	DNA-dependent DNA replication
E6C67_11200	COG4584	PFAM Integrase catalytic
E6C67_11200	COG2390	Transcriptional regulator
E6C67_11205	COG1484	DNA-dependent DNA replication
E6C67_11245	COG2948	multi-organism process
E6C67_11260	COG3316	Transposase and inactivated derivatives
E6C67_11265	COG2948	multi-organism process
E6C67_11295	COG1802	Transcriptional regulator
E6C67_11295	COG4626	Terminase
E6C67_11350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E6C67_11405	COG2197	response regulator
E6C67_11425	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
E6C67_11445	COG0784	Response regulator, receiver
E6C67_11445	COG4191	Histidine kinase
E6C67_11465	COG0583	DNA-binding transcription factor activity
E6C67_11470	COG1733	regulation of RNA biosynthetic process
E6C67_11475	COG0604	alcohol dehydrogenase
E6C67_11485	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_11490	COG4948	Mandelate Racemase Muconate Lactonizing
E6C67_11500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_11505	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_11515	COG0395	ABC-type sugar transport system, permease component
E6C67_11525	COG1653	transport
E6C67_11530	COG3842	ATPase activity
E6C67_11545	COG4670	ketone body catabolic process
E6C67_11550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E6C67_11580	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_11595	COG1802	Transcriptional regulator
E6C67_11630	COG4584	PFAM Integrase catalytic
E6C67_11635	COG1484	DNA-dependent DNA replication
E6C67_11645	COG3436	PFAM IS66 Orf2 family protein
E6C67_11665	COG0726	polysaccharide deacetylase
E6C67_11670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_11690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_11700	COG1414	Transcriptional regulator
E6C67_11710	COG2390	Transcriptional regulator
E6C67_11710	COG4584	PFAM Integrase catalytic
E6C67_11715	COG1484	DNA-dependent DNA replication
E6C67_11755	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_11760	COG1177	transmembrane transport
E6C67_11765	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_11770	COG1802	Transcriptional regulator
E6C67_11780	COG3958	Transketolase
E6C67_11785	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E6C67_11790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E6C67_11800	COG3842	ATPase activity
E6C67_11820	COG1454	alcohol dehydrogenase
E6C67_11830	COG0183	Belongs to the thiolase family
E6C67_11835	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_11845	COG1309	transcriptional regulator
E6C67_11850	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_11855	COG1024	Enoyl-CoA hydratase
E6C67_11875	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_11895	COG0601	transmembrane transport
E6C67_11905	COG0747	negative chemotaxis
E6C67_11910	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
E6C67_11915	COG0583	DNA-binding transcription factor activity
E6C67_11935	COG2814	Major facilitator Superfamily
E6C67_11950	COG4670	ketone body catabolic process
E6C67_11960	COG1053	succinate dehydrogenase
E6C67_11960	COG3976	FMN-binding domain protein
E6C67_11970	COG0583	DNA-binding transcription factor activity
E6C67_11985	COG0747	negative chemotaxis
E6C67_11990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C67_12005	COG1473	amidohydrolase
E6C67_12010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E6C67_12030	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_12035	COG0583	DNA-binding transcription factor activity
E6C67_12045	COG0583	DNA-binding transcription factor activity
E6C67_12050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_12055	COG1522	sequence-specific DNA binding
E6C67_12060	COG4172	Belongs to the ABC transporter superfamily
E6C67_12065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C67_12070	COG0601	transmembrane transport
E6C67_12075	COG0747	negative chemotaxis
E6C67_12090	COG0454	-acetyltransferase
E6C67_12100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_12115	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_12125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E6C67_12145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_12170	COG0583	DNA-binding transcription factor activity
E6C67_12175	COG1902	pentaerythritol trinitrate reductase activity
E6C67_12175	COG0446	pyridine nucleotide-disulphide oxidoreductase
E6C67_12190	COG0655	NAD(P)H dehydrogenase (quinone) activity
E6C67_12245	COG4584	PFAM Integrase catalytic
E6C67_12245	COG2390	Transcriptional regulator
E6C67_12250	COG1484	DNA-dependent DNA replication
E6C67_12260	COG2186	Transcriptional regulator
E6C67_12265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_12285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E6C67_12295	COG2807	transmembrane transport
E6C67_12320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_12335	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_12350	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_12355	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_12375	COG1024	Enoyl-CoA hydratase
E6C67_12410	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_12425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E6C67_12435	COG3829	transcription factor binding
E6C67_12445	COG1960	acyl-CoA dehydrogenase activity
E6C67_12450	COG5285	phytanoyl-CoA dioxygenase
E6C67_12495	COG2084	Dehydrogenase
E6C67_12560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E6C67_12590	COG4615	Cyclic peptide transporter
E6C67_12665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C67_12670	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E6C67_12675	COG0583	DNA-binding transcription factor activity
E6C67_12685	COG3842	ATPase activity
E6C67_12690	COG1840	ABC-type Fe3 transport system, periplasmic component
E6C67_12705	COG1595	DNA-templated transcription, initiation
E6C67_12740	COG0411	ABC transporter
E6C67_12745	COG1172	Belongs to the binding-protein-dependent transport system permease family
E6C67_12755	COG0683	leucine binding
E6C67_12765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E6C67_12825	COG0649	NAD binding
E6C67_12830	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C67_12840	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E6C67_12845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C67_12850	COG0651	ATP synthesis coupled electron transport
E6C67_12865	COG2414	aldehyde ferredoxin oxidoreductase
E6C67_12885	COG0577	efflux transmembrane transporter activity
E6C67_12885	COG1136	(ABC) transporter
E6C67_12890	COG0577	efflux transmembrane transporter activity
E6C67_12890	COG1136	(ABC) transporter
E6C67_12895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_12915	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C67_12930	COG4176	ABC-type proline glycine betaine transport system permease component
E6C67_12935	COG4175	Glycine betaine
E6C67_12950	COG0247	lactate metabolic process
E6C67_12950	COG2181	nitrate reductase activity
E6C67_12955	COG0446	pyridine nucleotide-disulphide oxidoreductase
E6C67_12955	COG1902	pentaerythritol trinitrate reductase activity
E6C67_12990	COG2223	nitrite transmembrane transporter activity
E6C67_13010	COG0577	efflux transmembrane transporter activity
E6C67_13010	COG1136	(ABC) transporter
E6C67_13015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E6C67_13035	COG1522	sequence-specific DNA binding
E6C67_13045	COG0411	ABC transporter
E6C67_13060	COG0683	leucine binding
E6C67_13075	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
E6C67_13095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C67_13115	COG2188	Transcriptional regulator
E6C67_13125	COG0405	Gamma-glutamyltransferase
E6C67_13130	COG2186	Transcriptional regulator
E6C67_13135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C67_13140	COG2204	response regulator
E6C67_13145	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_13150	COG3246	L-lysine catabolic process to acetate
E6C67_13155	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_13185	COG1960	acyl-CoA dehydrogenase activity
E6C67_13200	COG2010	Cytochrome c
E6C67_13200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E6C67_13205	COG2080	2 iron, 2 sulfur cluster binding
E6C67_13210	COG1846	Transcriptional regulator
E6C67_13215	COG2309	aminopeptidase activity
E6C67_13220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E6C67_13225	COG0596	Alpha beta hydrolase
E6C67_13230	COG3473	Maleate cis-trans isomerase
E6C67_13235	COG1335	isochorismatase
E6C67_13240	COG2271	Major facilitator Superfamily
E6C67_13245	COG0840	transmembrane signaling receptor activity
E6C67_13275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E6C67_13285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E6C67_13300	COG0405	Gamma-glutamyltransferase
E6C67_13305	COG0583	DNA-binding transcription factor activity
E6C67_13310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E6C67_13315	COG4948	Mandelate Racemase Muconate Lactonizing
E6C67_13325	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_13330	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_13355	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
E6C67_13360	COG0277	FAD linked oxidase domain protein
E6C67_13370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E6C67_13385	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C67_13390	COG0567	Dehydrogenase, E1 component
E6C67_13410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_13425	COG4584	PFAM Integrase catalytic
E6C67_13440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E6C67_13460	COG2801	Transposase and inactivated derivatives
E6C67_13470	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_13475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E6C67_13480	COG0596	Alpha beta hydrolase
E6C67_13500	COG4176	ABC-type proline glycine betaine transport system permease component
E6C67_13505	COG2113	Glycine betaine
E6C67_13535	COG3842	ATPase activity
E6C67_13550	COG2204	response regulator
E6C67_13555	COG4191	Histidine kinase
E6C67_13570	COG1846	Transcriptional regulator
E6C67_13575	COG0785	Cytochrome C biogenesis protein
E6C67_13575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C67_13585	COG0745	RESPONSE REGULATOR receiver
E6C67_13590	COG2205	protein histidine kinase activity
E6C67_13600	COG0488	(ABC) transporter
E6C67_13610	COG1959	2 iron, 2 sulfur cluster binding
E6C67_13625	COG0583	DNA-binding transcription factor activity
E6C67_13640	COG1959	2 iron, 2 sulfur cluster binding
E6C67_13650	COG1056	cytidyltransferase-related domain
E6C67_13650	COG1051	belongs to the nudix hydrolase family
E6C67_13660	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E6C67_13670	COG0754	glutathionylspermidine amidase activity
E6C67_13695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E6C67_13695	COG1213	nucleotidyl transferase
E6C67_13705	COG4589	Belongs to the CDS family
E6C67_13720	COG3712	iron ion homeostasis
E6C67_13745	COG4172	Belongs to the ABC transporter superfamily
E6C67_13750	COG0747	negative chemotaxis
E6C67_13790	COG3119	arylsulfatase activity
E6C67_13815	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_13825	COG1024	Enoyl-CoA hydratase
E6C67_13850	COG1917	Cupin 2, conserved barrel domain protein
E6C67_13850	COG2207	Transcriptional regulator
E6C67_13930	COG4615	Cyclic peptide transporter
E6C67_14000	COG2205	protein histidine kinase activity
E6C67_14000	COG0784	Response regulator, receiver
E6C67_14005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_14010	COG0765	amino acid transport
E6C67_14015	COG1126	abc transporter atp-binding protein
E6C67_14035	COG0714	Associated with various cellular activities
E6C67_14050	COG0626	cystathionine gamma-synthase activity
E6C67_14065	COG4191	Histidine kinase
E6C67_14075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E6C67_14075	COG0045	succinate-CoA ligase (ADP-forming) activity
E6C67_14075	COG1042	CoA-binding domain protein
E6C67_14080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_14110	COG3772	lysozyme
E6C67_14230	COG3728	DNA packaging
E6C67_14230	COG5484	DNA packaging
E6C67_14240	COG0250	Participates in transcription elongation, termination and antitermination
E6C67_14260	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E6C67_14320	COG2197	response regulator
E6C67_14420	COG3723	Recombinational DNA repair protein, rece pathway
E6C67_14460	COG0028	Belongs to the TPP enzyme family
E6C67_14465	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_14475	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E6C67_14485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E6C67_14505	COG0356	it plays a direct role in the translocation of protons across the membrane
E6C67_14515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E6C67_14520	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E6C67_14525	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E6C67_14540	COG2080	2 iron, 2 sulfur cluster binding
E6C67_14550	COG1294	oxidase, subunit
E6C67_14555	COG1271	oxidase subunit
E6C67_14560	COG2095	MarC family integral membrane protein
E6C67_14580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E6C67_14595	COG0745	RESPONSE REGULATOR receiver
E6C67_14620	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E6C67_14625	COG0408	coproporphyrinogen oxidase activity
E6C67_14655	COG0435	Glutathione S-transferase
E6C67_14660	COG0655	NAD(P)H dehydrogenase (quinone) activity
E6C67_14665	COG0583	DNA-binding transcription factor activity
E6C67_14675	COG2267	carboxylic ester hydrolase activity
E6C67_14695	COG3501	Rhs element vgr protein
E6C67_14710	COG1360	Flagellar Motor Protein
E6C67_14745	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_14755	COG0542	response to heat
E6C67_14775	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E6C67_14775	COG2885	chlorophyll binding
E6C67_14785	COG0697	spore germination
E6C67_14815	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E6C67_14845	COG0745	RESPONSE REGULATOR receiver
E6C67_14850	COG2172	sigma factor antagonist activity
E6C67_14855	COG5002	protein histidine kinase activity
E6C67_14880	COG0795	lipopolysaccharide-transporting ATPase activity
E6C67_14895	COG1104	cysteine desulfurase activity
E6C67_14920	COG1984	allophanate hydrolase subunit 2
E6C67_14925	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E6C67_14935	COG4336	lyase activity
E6C67_14945	COG0410	ABC transporter
E6C67_14950	COG0411	ABC transporter
E6C67_15010	COG2986	histidine ammonia-lyase
E6C67_15015	COG0402	S-adenosylhomocysteine deaminase activity
E6C67_15020	COG1228	amidohydrolase
E6C67_15025	COG2188	Transcriptional regulator
E6C67_15030	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E6C67_15035	COG2723	6-phospho-beta-galactosidase activity
E6C67_15055	COG0739	heme binding
E6C67_15055	COG1196	nuclear chromosome segregation
E6C67_15055	COG0741	lytic transglycosylase activity
E6C67_15080	COG0583	DNA-binding transcription factor activity
E6C67_15100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C67_15105	COG3842	ATPase activity
E6C67_15110	COG2182	Extracellular solute-binding protein
E6C67_15120	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_15130	COG1917	Cupin 2, conserved barrel domain protein
E6C67_15130	COG1396	sequence-specific DNA binding
E6C67_15135	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_15140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E6C67_15145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_15185	COG3273	potassium ion transport
E6C67_15185	COG0471	metal ion transport
E6C67_15215	COG2373	Large extracellular alpha-helical protein
E6C67_15230	COG0183	Belongs to the thiolase family
E6C67_15235	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_15235	COG1024	Enoyl-CoA hydratase
E6C67_15240	COG1960	acyl-CoA dehydrogenase activity
E6C67_15245	COG2197	response regulator
E6C67_15250	COG0516	GMP reductase activity
E6C67_15250	COG0517	IMP dehydrogenase activity
E6C67_15255	COG3047	cAMP biosynthetic process
E6C67_15290	COG1196	nuclear chromosome segregation
E6C67_15300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E6C67_15305	COG2084	Dehydrogenase
E6C67_15315	COG0679	Auxin Efflux Carrier
E6C67_15325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E6C67_15325	COG1199	ATP-dependent helicase activity
E6C67_15330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E6C67_15340	COG0513	Belongs to the DEAD box helicase family
E6C67_15350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_15355	COG0174	glutamine synthetase
E6C67_15365	COG0546	phosphoglycolate phosphatase activity
E6C67_15365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E6C67_15370	COG2076	Multidrug Resistance protein
E6C67_15390	COG0535	radical SAM domain protein
E6C67_15400	COG3842	ATPase activity
E6C67_15405	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_15410	COG1177	transmembrane transport
E6C67_15435	COG0745	RESPONSE REGULATOR receiver
E6C67_15435	COG3706	GGDEF domain
E6C67_15440	COG5002	protein histidine kinase activity
E6C67_15470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E6C67_15470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E6C67_15480	COG0243	molybdopterin cofactor binding
E6C67_15495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_15515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C67_15525	COG2271	Major facilitator Superfamily
E6C67_15530	COG0674	pyruvate-flavodoxin oxidoreductase activity
E6C67_15530	COG1013	pyruvate-flavodoxin oxidoreductase activity
E6C67_15530	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E6C67_15535	COG0246	Mannitol dehydrogenase
E6C67_15545	COG1609	Transcriptional regulator
E6C67_15555	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
E6C67_15560	COG1882	Formate acetyltransferase
E6C67_15575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E6C67_15595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C67_15600	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_15620	COG0800	Aldolase
E6C67_15625	COG3734	2-keto-3-deoxy-galactonokinase
E6C67_15630	COG1414	Transcriptional regulator
E6C67_15645	COG2329	Antibiotic biosynthesis monooxygenase
E6C67_15650	COG1741	Belongs to the pirin family
E6C67_15660	COG0316	Belongs to the HesB IscA family
E6C67_15665	COG2151	metal-sulfur cluster biosynthetic enzyme
E6C67_15670	COG0822	iron-sulfur transferase activity
E6C67_15675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E6C67_15680	COG0719	Fe-S assembly protein
E6C67_15685	COG0396	ATPase activity
E6C67_15690	COG2827	Endonuclease containing a URI domain
E6C67_15695	COG0719	Fe-S assembly protein
E6C67_15745	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E6C67_15750	COG0840	transmembrane signaling receptor activity
E6C67_15755	COG1475	DNA binding
E6C67_15760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C67_15765	COG1959	2 iron, 2 sulfur cluster binding
E6C67_15770	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_15775	COG3385	transposase activity
E6C67_15780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E6C67_15785	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E6C67_15790	COG0704	Plays a role in the regulation of phosphate uptake
E6C67_15800	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E6C67_15850	COG2207	Transcriptional regulator
E6C67_15865	COG1566	PFAM secretion protein HlyD family protein
E6C67_15870	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_15885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E6C67_15890	COG1024	Enoyl-CoA hydratase
E6C67_15915	COG2814	Major facilitator Superfamily
E6C67_15920	COG2207	Transcriptional regulator
E6C67_15925	COG1522	sequence-specific DNA binding
E6C67_15940	COG2015	COG2015, Alkyl sulfatase and related hydrolases
E6C67_15965	COG2610	gluconate transmembrane transporter activity
E6C67_16000	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_16005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_16010	COG0765	amino acid transport
E6C67_16015	COG2390	Transcriptional regulator
E6C67_16015	COG4584	PFAM Integrase catalytic
E6C67_16020	COG1484	DNA-dependent DNA replication
E6C67_16045	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E6C67_16050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E6C67_16095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E6C67_16100	COG1657	PFAM Prenyltransferase squalene oxidase
E6C67_16105	COG1562	ergosterol biosynthetic process
E6C67_16110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C67_16145	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E6C67_16150	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E6C67_16180	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E6C67_16190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_16195	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E6C67_16225	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E6C67_16235	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
E6C67_16240	COG2814	Major facilitator Superfamily
E6C67_16260	COG4566	intracellular signal transduction
E6C67_16265	COG4566	intracellular signal transduction
E6C67_16330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_16340	COG3384	dioxygenase
E6C67_16360	COG0411	ABC transporter
E6C67_16375	COG0683	leucine binding
E6C67_16385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
E6C67_16400	COG4191	Histidine kinase
E6C67_16405	COG4566	intracellular signal transduction
E6C67_16410	COG4566	intracellular signal transduction
E6C67_16440	COG0668	transmembrane transport
E6C67_16450	COG0583	DNA-binding transcription factor activity
E6C67_16455	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_16460	COG3959	Transketolase, thiamine diphosphate binding domain
E6C67_16465	COG3958	Transketolase
E6C67_16470	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_16475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_16480	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_16485	COG2084	Dehydrogenase
E6C67_16490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E6C67_16510	COG0346	lactoylglutathione lyase activity
E6C67_16515	COG3474	cytochrome
E6C67_16520	COG3385	transposase activity
E6C67_16560	COG0459	protein refolding
E6C67_16575	COG2188	Transcriptional regulator
E6C67_16585	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_16625	COG3976	FMN-binding domain protein
E6C67_16625	COG1053	succinate dehydrogenase
E6C67_16630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E6C67_16635	COG0066	3-isopropylmalate dehydratase activity
E6C67_16645	COG0366	Alpha amylase catalytic
E6C67_16665	COG1131	(ABC) transporter
E6C67_16675	COG2815	serine threonine protein kinase
E6C67_16675	COG0515	serine threonine protein kinase
E6C67_16680	COG2116	formate transmembrane transporter activity
E6C67_16700	COG0438	transferase activity, transferring glycosyl groups
E6C67_16715	COG0438	transferase activity, transferring glycosyl groups
E6C67_16735	COG3206	protein involved in exopolysaccharide biosynthesis
E6C67_16735	COG0489	protein tyrosine kinase activity
E6C67_16755	COG1609	Transcriptional regulator
E6C67_16760	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C67_16760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C67_16765	COG1105	Belongs to the carbohydrate kinase PfkB family
E6C67_16770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E6C67_16770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
E6C67_16805	COG0583	DNA-binding transcription factor activity
E6C67_16810	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E6C67_16815	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E6C67_16840	COG2132	Multicopper oxidase
E6C67_16855	COG0784	Response regulator, receiver
E6C67_16855	COG4191	Histidine kinase
E6C67_16860	COG3180	Ammonia monooxygenase
E6C67_16870	COG1309	transcriptional regulator
E6C67_16875	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_16880	COG1960	acyl-CoA dehydrogenase activity
E6C67_16890	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_16900	COG1233	COG1233 Phytoene dehydrogenase and related
E6C67_16920	COG3956	TIGRFAM MazG family protein
E6C67_16935	COG1566	PFAM secretion protein HlyD family protein
E6C67_16950	COG3852	Histidine kinase
E6C67_16990	COG0375	protein maturation
E6C67_16995	COG2204	response regulator
E6C67_17005	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E6C67_17015	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
E6C67_17025	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E6C67_17035	COG0659	secondary active sulfate transmembrane transporter activity
E6C67_17045	COG1755	Isoprenylcysteine carboxyl methyltransferase
E6C67_17050	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_17055	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_17065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_17075	COG0028	Belongs to the TPP enzyme family
E6C67_17095	COG4566	intracellular signal transduction
E6C67_17135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E6C67_17140	COG1522	sequence-specific DNA binding
E6C67_17145	COG2271	Major facilitator Superfamily
E6C67_17150	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_17160	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E6C67_17160	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E6C67_17175	COG0564	pseudouridine synthase activity
E6C67_17180	COG2205	protein histidine kinase activity
E6C67_17180	COG0784	Response regulator, receiver
E6C67_17185	COG1741	Belongs to the pirin family
E6C67_17190	COG3768	UPF0283 membrane protein
E6C67_17195	COG3106	COG3106 Predicted ATPase
E6C67_17220	COG0297	glycogen (starch) synthase activity
E6C67_17260	COG2342	PFAM TM1410 hypothetical-related protein
E6C67_17265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E6C67_17280	COG0521	Mo-molybdopterin cofactor biosynthetic process
E6C67_17290	COG0714	Associated with various cellular activities
E6C67_17295	COG3256	nitric oxide reductase
E6C67_17305	COG1845	cytochrome c oxidase, subunit III
E6C67_17320	COG3483	tryptophan 2,3-dioxygenase activity
E6C67_17330	COG1448	Aminotransferase
E6C67_17340	COG3012	SEC-C Motif Domain Protein
E6C67_17345	COG3437	response regulator, receiver
E6C67_17345	COG2770	Histidine kinase
E6C67_17430	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E6C67_17435	COG2068	MobA-Related Protein
E6C67_17440	COG0505	Belongs to the CarA family
E6C67_17445	COG0737	Belongs to the 5'-nucleotidase family
E6C67_17470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E6C67_17475	COG0784	Response regulator, receiver
E6C67_17475	COG3437	response regulator, receiver
E6C67_17480	COG0747	negative chemotaxis
E6C67_17485	COG4191	Histidine kinase
E6C67_17500	COG4176	ABC-type proline glycine betaine transport system permease component
E6C67_17505	COG4175	Glycine betaine
E6C67_17510	COG0183	Belongs to the thiolase family
E6C67_17515	COG1024	Enoyl-CoA hydratase
E6C67_17520	COG0477	Major facilitator Superfamily
E6C67_17525	COG1595	DNA-templated transcription, initiation
E6C67_17530	COG3806	Anti-sigma factor
E6C67_17540	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_17545	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_17545	COG1024	Enoyl-CoA hydratase
E6C67_17585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C67_17655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E6C67_17665	COG1737	Transcriptional regulator
E6C67_17695	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
E6C67_17715	COG1335	isochorismatase
E6C67_17720	COG1732	Glycine betaine
E6C67_17725	COG1174	glycine betaine transport
E6C67_17730	COG1125	glycine betaine transport
E6C67_17735	COG1174	glycine betaine transport
E6C67_17740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E6C67_17745	COG0022	dehydrogenase e1 component
E6C67_17755	COG3008	intermembrane lipid transfer
E6C67_17760	COG2995	paraquat-inducible protein a
E6C67_17765	COG2188	Transcriptional regulator
E6C67_17775	COG0765	amino acid transport
E6C67_17785	COG1126	abc transporter atp-binding protein
E6C67_17790	COG4115	mRNA cleavage
E6C67_17795	COG2161	toxin-antitoxin pair type II binding
E6C67_17800	COG1122	ATPase activity
E6C67_17810	COG1268	BioY protein
E6C67_17815	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_17820	COG0183	Belongs to the thiolase family
E6C67_17835	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E6C67_17865	COG0784	Response regulator, receiver
E6C67_17865	COG5002	protein histidine kinase activity
E6C67_17870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E6C67_17875	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E6C67_17890	COG0659	secondary active sulfate transmembrane transporter activity
E6C67_17920	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
E6C67_17925	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E6C67_17935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E6C67_17940	COG0142	geranyltranstransferase activity
E6C67_17950	COG0123	including yeast histone deacetylase and acetoin utilization protein
E6C67_17960	COG0640	Transcriptional regulator
E6C67_17965	COG2363	Small membrane protein
E6C67_17980	COG5002	protein histidine kinase activity
E6C67_17980	COG5001	Diguanylate cyclase
E6C67_18010	COG0154	amidase activity
E6C67_18015	COG4178	(ABC) transporter
E6C67_18045	COG5489	Protein of unknown function (DUF736)
E6C67_18085	COG1192	Involved in chromosome partitioning
E6C67_18135	COG3451	type IV secretory pathway VirB4
E6C67_18195	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E6C67_18250	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E6C67_18260	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_18270	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_18285	COG1309	transcriptional regulator
E6C67_18295	COG4447	cellulose binding
E6C67_18330	COG1024	Enoyl-CoA hydratase
E6C67_18335	COG1250	3-hydroxyacyl-CoA dehydrogenase
E6C67_18340	COG0183	Belongs to the thiolase family
E6C67_18385	COG0589	response to stress
E6C67_18390	COG0386	Belongs to the glutathione peroxidase family
E6C67_18395	COG1733	regulation of RNA biosynthetic process
E6C67_18400	COG0702	epimerase
E6C67_18425	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_18455	COG0179	Fumarylacetoacetate (FAA) hydrolase
E6C67_18475	COG0604	alcohol dehydrogenase
E6C67_18570	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C67_18575	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C67_18575	COG0022	dehydrogenase e1 component
E6C67_18580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E6C67_18585	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C67_18595	COG0071	Belongs to the small heat shock protein (HSP20) family
E6C67_18625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E6C67_18660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C67_18660	COG0574	Belongs to the PEP-utilizing enzyme family
E6C67_18665	COG2249	NAD(P)H dehydrogenase (quinone) activity
E6C67_18680	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_18685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E6C67_18705	COG3706	GGDEF domain
E6C67_18715	COG1984	allophanate hydrolase subunit 2
E6C67_18720	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E6C67_18725	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_18740	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C67_18760	COG4172	Belongs to the ABC transporter superfamily
E6C67_18765	COG0747	negative chemotaxis
E6C67_18770	COG0601	transmembrane transport
E6C67_18775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C67_18785	COG2362	D-Aminopeptidase
E6C67_18790	COG1446	asparaginase
E6C67_18815	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E6C67_18840	COG3385	transposase activity
E6C67_18845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_18855	COG5383	Protein conserved in bacteria
E6C67_18860	COG5001	Diguanylate cyclase
E6C67_18860	COG4251	negative regulation of phosphorylation
E6C67_18860	COG3706	GGDEF domain
E6C67_18860	COG2203	Gaf domain
E6C67_18880	COG2814	Major facilitator Superfamily
E6C67_18885	COG0798	PFAM Bile acid sodium symporter
E6C67_18925	COG2133	pyrroloquinoline quinone binding
E6C67_18935	COG0459	protein refolding
E6C67_18940	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E6C67_18955	COG1063	alcohol dehydrogenase
E6C67_18975	COG0745	RESPONSE REGULATOR receiver
E6C67_18995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E6C67_19000	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E6C67_19005	COG2080	2 iron, 2 sulfur cluster binding
E6C67_19015	COG0395	ABC-type sugar transport system, permease component
E6C67_19025	COG0363	glucosamine-6-phosphate deaminase activity
E6C67_19030	COG0673	inositol 2-dehydrogenase activity
E6C67_19035	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_19040	COG1840	ABC-type Fe3 transport system, periplasmic component
E6C67_19045	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E6C67_19050	COG3842	ATPase activity
E6C67_19055	COG1177	transmembrane transport
E6C67_19060	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_19070	COG1609	Transcriptional regulator
E6C67_19090	COG2153	protein acetylation
E6C67_19100	COG2116	formate transmembrane transporter activity
E6C67_19110	COG5001	Diguanylate cyclase
E6C67_19115	COG0784	Response regulator, receiver
E6C67_19115	COG3437	response regulator, receiver
E6C67_19120	COG0469	pyruvate kinase activity
E6C67_19135	COG2205	protein histidine kinase activity
E6C67_19140	COG0745	RESPONSE REGULATOR receiver
E6C67_19180	COG0455	bacterial-type flagellum organization
E6C67_19190	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E6C67_19195	COG2204	response regulator
E6C67_19200	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E6C67_19205	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C67_19215	COG1766	The M ring may be actively involved in energy transduction
E6C67_19220	COG1396	sequence-specific DNA binding
E6C67_19245	COG1253	flavin adenine dinucleotide binding
E6C67_19265	COG2198	Histidine kinase
E6C67_19265	COG5002	protein histidine kinase activity
E6C67_19265	COG0784	Response regulator, receiver
E6C67_19275	COG2030	dehydratase
E6C67_19275	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_19285	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E6C67_19295	COG0840	transmembrane signaling receptor activity
E6C67_19315	COG0745	RESPONSE REGULATOR receiver
E6C67_19320	COG0784	Response regulator, receiver
E6C67_19320	COG5002	protein histidine kinase activity
E6C67_19325	COG1363	Peptidase, m42
E6C67_19330	COG0189	ligase activity
E6C67_19330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E6C67_19335	COG0367	asparagine synthase
E6C67_19340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_19350	COG3791	Glutathione-dependent formaldehyde-activating
E6C67_19355	COG2080	2 iron, 2 sulfur cluster binding
E6C67_19360	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
E6C67_19365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E6C67_19370	COG3385	transposase activity
E6C67_19385	COG1840	ABC-type Fe3 transport system, periplasmic component
E6C67_19400	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E6C67_19425	COG1304	FMN binding
E6C67_19435	COG3707	response regulator
E6C67_19445	COG1846	Transcriptional regulator
E6C67_19450	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E6C67_19460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_19475	COG2226	methyltransferase
E6C67_19530	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E6C67_19540	COG4208	sulfate ABC transporter
E6C67_19545	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E6C67_19570	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E6C67_19575	COG0367	asparagine synthase
E6C67_19580	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_19595	COG0438	transferase activity, transferring glycosyl groups
E6C67_19600	COG0438	transferase activity, transferring glycosyl groups
E6C67_19605	COG1216	Glycosyl transferase, family 2
E6C67_19625	COG1045	serine acetyltransferase
E6C67_19630	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
E6C67_19645	COG0489	protein tyrosine kinase activity
E6C67_19645	COG3206	protein involved in exopolysaccharide biosynthesis
E6C67_19655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E6C67_19660	COG0588	phosphoglycerate mutase activity
E6C67_19675	COG5002	protein histidine kinase activity
E6C67_19690	COG2089	acid synthase
E6C67_19695	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
E6C67_19715	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_19720	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_19725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E6C67_19740	COG0457	Tetratricopeptide repeat
E6C67_19740	COG0859	PFAM glycosyl transferase family 9
E6C67_19755	COG0859	PFAM glycosyl transferase family 9
E6C67_19755	COG0457	Tetratricopeptide repeat
E6C67_19760	COG2226	methyltransferase
E6C67_19785	COG1558	bacterial-type flagellum-dependent cell motility
E6C67_19800	COG0366	Alpha amylase catalytic
E6C67_19805	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C67_19820	COG1749	Flagellar hook protein flgE
E6C67_19820	COG1749	Flagellar hook protein flgE
E6C67_19845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_19845	COG4191	Histidine kinase
E6C67_19850	COG0737	Belongs to the 5'-nucleotidase family
E6C67_19860	COG3385	transposase activity
E6C67_19875	COG0625	glutathione transferase activity
E6C67_19885	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_19895	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_19905	COG0411	ABC transporter
E6C67_19910	COG0410	ABC transporter
E6C67_19920	COG1024	Enoyl-CoA hydratase
E6C67_19930	COG0745	RESPONSE REGULATOR receiver
E6C67_19945	COG1640	4-alpha-glucanotransferase
E6C67_19965	COG4191	Histidine kinase
E6C67_19970	COG1301	dicarboxylic acid transport
E6C67_19975	COG0281	malic enzyme
E6C67_19975	COG0280	phosphate acetyltransferase
E6C67_19985	COG0859	PFAM glycosyl transferase family 9
E6C67_19985	COG0457	Tetratricopeptide repeat
E6C67_20005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C67_20040	COG2847	Copper chaperone PCu(A)C
E6C67_20055	COG0784	Response regulator, receiver
E6C67_20060	COG3920	Histidine kinase
E6C67_20060	COG2202	Pas domain
E6C67_20065	COG0784	Response regulator, receiver
E6C67_20070	COG4251	negative regulation of phosphorylation
E6C67_20095	COG2183	response to ionizing radiation
E6C67_20100	COG1280	lysine exporter protein (LysE YggA)
E6C67_20130	COG0393	Putative heavy-metal-binding
E6C67_20135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E6C67_20155	COG1309	transcriptional regulator
E6C67_20160	COG3706	GGDEF domain
E6C67_20165	COG0772	Belongs to the SEDS family
E6C67_20170	COG2273	Hydrolase Family 16
E6C67_20175	COG0411	ABC transporter
E6C67_20185	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_20225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_20240	COG1131	(ABC) transporter
E6C67_20255	COG2169	Transcriptional regulator
E6C67_20255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E6C67_20285	COG0420	3'-5' exonuclease activity
E6C67_20310	COG0805	protein transport
E6C67_20315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E6C67_20320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E6C67_20325	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E6C67_20330	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E6C67_20335	COG1994	Peptidase M50
E6C67_20355	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E6C67_20360	COG0316	Belongs to the HesB IscA family
E6C67_20395	COG0308	aminopeptidase N
E6C67_20415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E6C67_20430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C67_20445	COG0463	Glycosyl transferase, family 2
E6C67_20450	COG0740	serine-type endopeptidase activity
E6C67_20500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C67_20530	COG0410	ABC transporter
E6C67_20535	COG0411	ABC transporter
E6C67_20540	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_20550	COG0697	spore germination
E6C67_20560	COG3411	Ferredoxin
E6C67_20575	COG0295	cytidine deaminase activity
E6C67_20580	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E6C67_20585	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E6C67_20590	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E6C67_20615	COG3546	catalase activity
E6C67_20620	COG2223	nitrite transmembrane transporter activity
E6C67_20625	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E6C67_20650	COG1177	transmembrane transport
E6C67_20655	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_20660	COG3842	ATPase activity
E6C67_20665	COG1414	Transcriptional regulator
E6C67_20685	COG4603	Belongs to the binding-protein-dependent transport system permease family
E6C67_20695	COG0402	S-adenosylhomocysteine deaminase activity
E6C67_20700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E6C67_20710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E6C67_20730	COG2814	Major facilitator Superfamily
E6C67_20750	COG2217	Heavy metal translocating P-type atpase
E6C67_20760	COG2860	membrane
E6C67_20780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E6C67_20800	COG0142	geranyltranstransferase activity
E6C67_20810	COG2890	protein-(glutamine-N5) methyltransferase activity
E6C67_20835	COG1666	GTP binding
E6C67_20840	COG4608	Belongs to the ABC transporter superfamily
E6C67_20845	COG0444	Belongs to the ABC transporter superfamily
E6C67_20850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E6C67_20855	COG0601	transmembrane transport
E6C67_20860	COG0747	negative chemotaxis
E6C67_20865	COG0697	spore germination
E6C67_20885	COG0784	Response regulator, receiver
E6C67_20900	COG0860	N-Acetylmuramoyl-L-alanine amidase
E6C67_20920	COG1414	Transcriptional regulator
E6C67_20925	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E6C67_20930	COG0045	succinate-CoA ligase (ADP-forming) activity
E6C67_20935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_20945	COG1802	Transcriptional regulator
E6C67_20950	COG1414	Transcriptional regulator
E6C67_20960	COG4221	oxidoreductase activity
E6C67_20970	COG3960	tartronate-semialdehyde synthase activity
E6C67_20975	COG2351	hydroxyisourate hydrolase activity
E6C67_20995	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E6C67_21000	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E6C67_21005	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E6C67_21010	COG0517	IMP dehydrogenase activity
E6C67_21015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E6C67_21040	COG0517	IMP dehydrogenase activity
E6C67_21050	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C67_21050	COG0574	Belongs to the PEP-utilizing enzyme family
E6C67_21070	COG1802	Transcriptional regulator
E6C67_21075	COG0352	thiamine-phosphate diphosphorylase activity
E6C67_21115	COG0546	phosphoglycolate phosphatase activity
E6C67_21135	COG3547	Transposase (IS116 IS110 IS902 family)
E6C67_21145	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_21160	COG4584	PFAM Integrase catalytic
E6C67_21165	COG1484	DNA-dependent DNA replication
E6C67_21215	COG4191	Histidine kinase
E6C67_21220	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E6C67_21235	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C67_21245	COG0728	peptidoglycan biosynthetic process
E6C67_21250	COG0596	Alpha beta hydrolase
E6C67_21255	COG0148	phosphopyruvate hydratase activity
E6C67_21270	COG0678	peroxiredoxin activity
E6C67_21295	COG3243	poly(R)-hydroxyalkanoic acid synthase
E6C67_21300	COG4991	sh3 domain protein
E6C67_21300	COG3064	Membrane
E6C67_21300	COG0515	serine threonine protein kinase
E6C67_21310	COG1902	pentaerythritol trinitrate reductase activity
E6C67_21340	COG0640	Transcriptional regulator
E6C67_21355	COG0640	Transcriptional regulator
E6C67_21365	COG0446	pyridine nucleotide-disulphide oxidoreductase
E6C67_21375	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_21390	COG0683	leucine binding
E6C67_21400	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_21415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C67_21420	COG1309	transcriptional regulator
E6C67_21425	COG0840	transmembrane signaling receptor activity
E6C67_21435	COG2205	protein histidine kinase activity
E6C67_21450	COG2264	protein methyltransferase activity
E6C67_21495	COG1024	Enoyl-CoA hydratase
E6C67_21500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E6C67_21505	COG1960	acyl-CoA dehydrogenase activity
E6C67_21510	COG0183	Belongs to the thiolase family
E6C67_21515	COG1960	acyl-CoA dehydrogenase activity
E6C67_21540	COG0784	Response regulator, receiver
E6C67_21540	COG2205	protein histidine kinase activity
E6C67_21575	COG2902	Dehydrogenase
E6C67_21605	COG1192	Involved in chromosome partitioning
E6C67_21610	COG1475	DNA binding
E6C67_21615	COG3385	transposase activity
E6C67_21620	COG0747	negative chemotaxis
E6C67_21630	COG2205	protein histidine kinase activity
E6C67_21630	COG0784	Response regulator, receiver
E6C67_21630	COG2198	Histidine kinase
E6C67_21635	COG2202	Pas domain
E6C67_21635	COG2205	protein histidine kinase activity
E6C67_21690	COG0583	DNA-binding transcription factor activity
E6C67_21705	COG3383	formate dehydrogenase (NAD+) activity
E6C67_21710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E6C67_21755	COG0411	ABC transporter
E6C67_21760	COG0410	ABC transporter
E6C67_21780	COG0625	glutathione transferase activity
E6C67_21785	COG0583	DNA-binding transcription factor activity
E6C67_21790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E6C67_21810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E6C67_21815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E6C67_21820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E6C67_21825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E6C67_21830	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E6C67_21830	COG2885	chlorophyll binding
E6C67_21850	COG0366	Alpha amylase catalytic
E6C67_21855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E6C67_21875	COG0745	RESPONSE REGULATOR receiver
E6C67_21880	COG1640	4-alpha-glucanotransferase
E6C67_21905	COG4453	Protein conserved in bacteria
E6C67_21920	COG4227	nucleotidyltransferase activity
E6C67_21975	COG1247	-acetyltransferase
E6C67_21980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E6C67_21980	COG0519	Catalyzes the synthesis of GMP from XMP
E6C67_22020	COG1914	H( )-stimulated, divalent metal cation uptake system
E6C67_22025	COG2900	Belongs to the SlyX family
E6C67_22030	COG1160	GTP binding
E6C67_22045	COG2197	response regulator
E6C67_22055	COG3290	protein histidine kinase activity
E6C67_22055	COG0840	transmembrane signaling receptor activity
E6C67_22060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E6C67_22115	COG3321	synthase
E6C67_22115	COG0604	alcohol dehydrogenase
E6C67_22115	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_22125	COG0163	prenyltransferase activity
E6C67_22130	COG0288	reversible hydration of carbon dioxide
E6C67_22155	COG0205	6-phosphofructokinase activity
E6C67_22170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E6C67_22175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E6C67_22190	COG5001	Diguanylate cyclase
E6C67_22210	COG0114	fumarate hydratase activity
E6C67_22235	COG2951	lytic endotransglycosylase activity
E6C67_22275	COG4191	Histidine kinase
E6C67_22285	COG3385	transposase activity
E6C67_22290	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C67_22295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_22315	COG1366	Belongs to the anti-sigma-factor antagonist family
E6C67_22320	COG2770	Histidine kinase
E6C67_22320	COG2208	phosphoserine phosphatase activity
E6C67_22370	COG3501	Rhs element vgr protein
E6C67_22445	COG0500	methyltransferase
E6C67_22470	COG2815	serine threonine protein kinase
E6C67_22470	COG0515	serine threonine protein kinase
E6C67_22490	COG0745	RESPONSE REGULATOR receiver
E6C67_22510	COG0105	UTP biosynthetic process
E6C67_22520	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E6C67_22525	COG1012	belongs to the aldehyde dehydrogenase family
E6C67_22530	COG0488	(ABC) transporter
E6C67_22535	COG3932	Exopolysaccharide synthesis, ExoD
E6C67_22560	COG1686	Belongs to the peptidase S11 family
E6C67_22565	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E6C67_22570	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E6C67_22575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E6C67_22580	COG0084	hydrolase, TatD family'
E6C67_22585	COG0321	lipoyl(octanoyl) transferase activity
E6C67_22585	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
E6C67_22590	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C67_22620	COG1381	Involved in DNA repair and RecF pathway recombination
E6C67_22625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E6C67_22650	COG4786	Flagellar basal body rod
E6C67_22655	COG4786	Flagellar basal body rod
E6C67_22665	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E6C67_22690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E6C67_22690	COG4651	solute:proton antiporter activity
E6C67_22695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E6C67_22745	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E6C67_22755	COG1024	Enoyl-CoA hydratase
E6C67_22760	COG0758	DNA mediated transformation
E6C67_22765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E6C67_22770	COG1024	Enoyl-CoA hydratase
E6C67_22775	COG1832	CoA-binding protein
E6C67_22810	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E6C67_22840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E6C67_22850	COG0745	RESPONSE REGULATOR receiver
E6C67_22850	COG3706	GGDEF domain
E6C67_22860	COG3447	MASE1 domain protein
E6C67_22860	COG5001	Diguanylate cyclase
E6C67_22860	COG5002	protein histidine kinase activity
E6C67_22880	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E6C67_22895	COG1238	metal cluster binding
E6C67_22900	COG0203	ribosomal protein L17
E6C67_22915	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E6C67_22930	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E6C67_22935	COG0251	oxidation-reduction process
E6C67_22995	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E6C67_22995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E6C67_23030	COG0154	amidase activity
E6C67_23035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E6C67_23045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E6C67_23055	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
E6C67_23080	COG0242	peptide deformylase activity
E6C67_23085	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E6C67_23090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E6C67_23095	COG1201	RNA secondary structure unwinding
E6C67_23105	COG0415	Belongs to the DNA photolyase family
E6C67_23110	COG0735	belongs to the Fur family
E6C67_23115	COG0523	cobalamin synthesis protein
E6C67_23125	COG0840	transmembrane signaling receptor activity
E6C67_23130	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E6C67_23145	COG2205	protein histidine kinase activity
E6C67_23155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E6C67_23160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E6C67_23160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E6C67_23175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E6C67_23175	COG0357	Ribosomal RNA small subunit methyltransferase G
E6C67_23180	COG4251	negative regulation of phosphorylation
E6C67_23185	COG0494	nUDIX hydrolase
E6C67_23195	COG0497	DNA recombination
E6C67_23200	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E6C67_23215	COG0745	RESPONSE REGULATOR receiver
E6C67_23220	COG0006	proline dipeptidase activity
E6C67_23230	COG2264	protein methyltransferase activity
E6C67_23240	COG0210	DNA helicase
E6C67_23245	COG2197	response regulator
E6C67_23250	COG2197	response regulator
E6C67_23280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E6C67_23295	COG2910	NAD(P)H-binding
E6C67_23305	COG0366	Alpha amylase catalytic
E6C67_23320	COG0742	ribosomal rna small subunit methyltransferase
E6C67_23325	COG1187	pseudouridine synthase activity
E6C67_23330	COG0590	tRNA wobble adenosine to inosine editing
E6C67_23340	COG1895	HEPN domain
E6C67_23355	COG1570	exodeoxyribonuclease VII activity
E6C67_23360	COG0418	dihydroorotase activity
E6C67_23410	COG5001	Diguanylate cyclase
E6C67_23410	COG3300	MHYT domain
E6C67_23415	COG1283	sodium-dependent phosphate transmembrane transporter activity
E6C67_23420	COG0012	GTP binding
E6C67_23425	COG0193	aminoacyl-tRNA hydrolase activity
E6C67_23430	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E6C67_23455	COG2945	thiolester hydrolase activity
E6C67_23460	COG1045	serine acetyltransferase
E6C67_23475	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E6C67_23485	COG0482	sulfurtransferase activity
E6C67_23500	COG3706	GGDEF domain
E6C67_23500	COG0745	RESPONSE REGULATOR receiver
E6C67_23505	COG3284	Transcriptional regulator
E6C67_23515	COG0456	acetyltransferase
E6C67_23535	COG0697	spore germination
E6C67_23540	COG3023	N-Acetylmuramoyl-L-alanine amidase
E6C67_23550	COG2001	Belongs to the MraZ family
E6C67_23570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E6C67_23580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E6C67_23585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E6C67_23595	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E6C67_23605	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E6C67_23610	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E6C67_23615	COG1181	Belongs to the D-alanine--D-alanine ligase family
E6C67_23620	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E6C67_23625	COG0849	cell division
E6C67_23630	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E6C67_23670	COG0248	Ppx GppA phosphatase
E6C67_23680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E6C67_23690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E6C67_23705	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E6C67_23795	COG0546	phosphoglycolate phosphatase activity
E6C67_23800	COG0564	pseudouridine synthase activity
E6C67_23805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E6C67_23810	COG1335	isochorismatase
E6C67_23825	COG1136	(ABC) transporter
E6C67_23835	COG0442	prolyl-tRNA aminoacylation
E6C67_23850	COG0519	Catalyzes the synthesis of GMP from XMP
E6C67_23880	COG1007	ATP synthesis coupled electron transport
E6C67_23895	COG0713	ATP synthesis coupled electron transport
E6C67_23910	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E6C67_23915	COG1034	ATP synthesis coupled electron transport
E6C67_23920	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E6C67_23925	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E6C67_23930	COG0649	NAD binding
E6C67_23935	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C67_23940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C67_23945	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E6C67_24000	COG0492	ferredoxin-NADP+ reductase activity
E6C67_24030	COG1484	DNA-dependent DNA replication
E6C67_24035	COG4584	PFAM Integrase catalytic
E6C67_24035	COG2390	Transcriptional regulator
E6C67_24055	COG0500	methyltransferase
E6C67_24060	COG0140	phosphoribosyl-ATP diphosphatase activity
E6C67_24065	COG0704	Plays a role in the regulation of phosphate uptake
E6C67_24070	COG2862	Uncharacterized protein family, UPF0114
E6C67_24090	COG0768	penicillin binding
E6C67_24105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E6C67_24115	COG0028	Belongs to the TPP enzyme family
E6C67_24120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E6C67_24125	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E6C67_24140	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E6C67_24155	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E6C67_24160	COG0830	nickel cation binding
E6C67_24170	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E6C67_24175	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E6C67_24180	COG0804	urea catabolic process
E6C67_24185	COG0832	Belongs to the urease beta subunit family
E6C67_24190	COG0831	urea catabolic process
E6C67_24195	COG0829	nickel cation binding
E6C67_24200	COG2197	response regulator
E6C67_24205	COG2197	response regulator
E6C67_24210	COG0693	protein deglycase activity
E6C67_24225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E6C67_24230	COG0717	Belongs to the dCTP deaminase family
E6C67_24250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E6C67_24285	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E6C67_24295	COG0557	exoribonuclease II activity
E6C67_24300	COG0793	Belongs to the peptidase S41A family
E6C67_24305	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E6C67_24310	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E6C67_24330	COG1380	Effector of murein hydrolase LrgA
E6C67_24335	COG1346	cytolysis
E6C67_24340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E6C67_24365	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E6C67_24395	COG4191	Histidine kinase
E6C67_24395	COG0784	Response regulator, receiver
E6C67_24415	COG1131	(ABC) transporter
E6C67_24425	COG1309	transcriptional regulator
E6C67_24445	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E6C67_24460	COG5554	nitrogen fixation
E6C67_24485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E6C67_24515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E6C67_24525	COG0745	RESPONSE REGULATOR receiver
E6C67_24530	COG2176	DNA-directed DNA polymerase activity
E6C67_24530	COG5002	protein histidine kinase activity
E6C67_24540	COG5002	protein histidine kinase activity
E6C67_24545	COG2204	response regulator
E6C67_24550	COG3852	Histidine kinase
E6C67_24555	COG2204	response regulator
E6C67_24585	COG0519	Catalyzes the synthesis of GMP from XMP
E6C67_24600	COG0752	glycyl-tRNA synthetase alpha subunit
E6C67_24605	COG0751	glycine-tRNA ligase activity
E6C67_24640	COG2770	Histidine kinase
E6C67_24640	COG3437	response regulator, receiver
E6C67_24645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E6C67_24650	COG1234	tRNA 3'-trailer cleavage
E6C67_24655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E6C67_24660	COG0047	phosphoribosylformylglycinamidine synthase activity
E6C67_24665	COG0004	ammonium transporteR
E6C67_24670	COG0312	modulator of DNA gyrase
E6C67_24690	COG1846	Transcriptional regulator
E6C67_24700	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
E6C67_24735	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E6C67_24745	COG0463	Glycosyl transferase, family 2
E6C67_24750	COG0840	transmembrane signaling receptor activity
E6C67_24765	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
E6C67_24770	COG3118	belongs to the thioredoxin family
E6C67_24780	COG2835	tetraacyldisaccharide 4'-kinase activity
E6C67_24790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E6C67_24805	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_24810	COG0183	Belongs to the thiolase family
E6C67_24815	COG3243	poly(R)-hydroxyalkanoic acid synthase
E6C67_24820	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
E6C67_24855	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
E6C67_24865	COG0842	Transport permease protein
E6C67_24870	COG1132	(ABC) transporter
E6C67_24875	COG0254	rRNA binding
E6C67_24885	COG0071	Belongs to the small heat shock protein (HSP20) family
E6C67_24900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E6C67_24905	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E6C67_24910	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E6C67_24920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C67_24935	COG0793	Belongs to the peptidase S41A family
E6C67_24940	COG4942	peptidase
E6C67_24945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E6C67_24950	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E6C67_24955	COG0799	negative regulation of ribosome biogenesis
E6C67_24960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E6C67_24975	COG1051	belongs to the nudix hydrolase family
E6C67_24990	COG0643	Histidine kinase
E6C67_24990	COG2198	Histidine kinase
E6C67_24995	COG0835	chemotaxis
E6C67_25000	COG0840	transmembrane signaling receptor activity
E6C67_25010	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
E6C67_25015	COG2201	protein-glutamate methylesterase activity
E6C67_25020	COG0840	transmembrane signaling receptor activity
E6C67_25025	COG1366	Belongs to the anti-sigma-factor antagonist family
E6C67_25040	COG3706	GGDEF domain
E6C67_25040	COG0745	RESPONSE REGULATOR receiver
E6C67_25045	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E6C67_25050	COG0579	oxidoreductase
E6C67_25055	COG0071	Belongs to the small heat shock protein (HSP20) family
E6C67_25085	COG1322	Protein conserved in bacteria
E6C67_25100	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_25150	COG1278	Cold shock
E6C67_25155	COG1902	pentaerythritol trinitrate reductase activity
E6C67_25160	COG0328	RNA-DNA hybrid ribonuclease activity
E6C67_25160	COG0406	alpha-ribazole phosphatase activity
E6C67_25165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E6C67_25185	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E6C67_25195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E6C67_25200	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E6C67_25215	COG0277	FAD linked oxidase domain protein
E6C67_25220	COG0009	L-threonylcarbamoyladenylate synthase
E6C67_25225	COG1192	Involved in chromosome partitioning
E6C67_25235	COG2193	ferroxidase activity
E6C67_25245	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_25250	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E6C67_25255	COG0747	negative chemotaxis
E6C67_25270	COG4191	Histidine kinase
E6C67_25275	COG0101	tRNA pseudouridine synthase activity
E6C67_25280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E6C67_25285	COG0242	peptide deformylase activity
E6C67_25290	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E6C67_25310	COG1595	DNA-templated transcription, initiation
E6C67_25325	COG0745	RESPONSE REGULATOR receiver
E6C67_25325	COG3706	GGDEF domain
E6C67_25350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E6C67_25365	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_25380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C67_25395	COG2350	Protein conserved in bacteria
E6C67_25415	COG0681	Belongs to the peptidase S26 family
E6C67_25420	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E6C67_25430	COG2205	protein histidine kinase activity
E6C67_25440	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E6C67_25465	COG0586	Pfam SNARE associated Golgi protein
E6C67_25485	COG1278	Cold shock
E6C67_25515	COG0410	ABC transporter
E6C67_25530	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_25540	COG3327	negative regulation of DNA-templated transcription, initiation
E6C67_25565	COG0840	transmembrane signaling receptor activity
E6C67_25575	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E6C67_25595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E6C67_25615	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E6C67_25620	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E6C67_25635	COG0167	dihydroorotate dehydrogenase activity
E6C67_25695	COG3385	transposase activity
E6C67_25710	COG2032	superoxide dismutase activity
E6C67_25720	COG0625	glutathione transferase activity
E6C67_25730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E6C67_25740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E6C67_25750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E6C67_25770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E6C67_25780	COG4974	Belongs to the 'phage' integrase family
E6C67_25785	COG0840	transmembrane signaling receptor activity
E6C67_25815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E6C67_25835	COG1278	Cold shock
E6C67_25845	COG4191	Histidine kinase
E6C67_25855	COG4106	trans-aconitate 2-methyltransferase activity
E6C67_25870	COG0126	phosphoglycerate kinase activity
E6C67_25885	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E6C67_25900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E6C67_25905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E6C67_25915	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
E6C67_25920	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E6C67_25960	COG1058	Belongs to the CinA family
E6C67_25960	COG1546	Belongs to the CinA family
E6C67_25965	COG1489	DNA binding
E6C67_25970	COG0024	Methionine aminopeptidase
E6C67_25985	COG0514	ATP-dependent DNA helicase (RecQ)
E6C67_25990	COG0494	nUDIX hydrolase
E6C67_25995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E6C67_26000	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E6C67_26005	COG0653	protein targeting
E6C67_26010	COG1970	mechanosensitive ion channel activity
E6C67_26025	COG0640	Transcriptional regulator
E6C67_26030	COG2076	Multidrug Resistance protein
E6C67_26035	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
E6C67_26050	COG0039	L-malate dehydrogenase activity
E6C67_26055	COG0045	succinate-CoA ligase (ADP-forming) activity
E6C67_26085	COG4191	Histidine kinase
E6C67_26120	COG1643	Atp-dependent helicase
E6C67_26140	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E6C67_26155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C67_26155	COG0574	Belongs to the PEP-utilizing enzyme family
E6C67_26160	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
E6C67_26165	COG1396	sequence-specific DNA binding
E6C67_26170	COG0574	Belongs to the PEP-utilizing enzyme family
E6C67_26170	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C67_26180	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E6C67_26190	COG0539	negative regulation of cytoplasmic translation
E6C67_26245	COG1238	metal cluster binding
E6C67_26250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E6C67_26270	COG1674	ftsk spoiiie
E6C67_26275	COG2318	DinB family
E6C67_26285	COG2205	protein histidine kinase activity
E6C67_26305	COG0243	molybdopterin cofactor binding
E6C67_26315	COG3005	denitrification pathway
E6C67_26330	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E6C67_26335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E6C67_26350	COG1522	sequence-specific DNA binding
E6C67_26355	COG3660	Nucleoside-diphosphate-sugar epimerase
E6C67_26400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E6C67_26410	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E6C67_26420	COG0861	Integral membrane protein TerC family
E6C67_26435	COG0583	DNA-binding transcription factor activity
E6C67_26455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E6C67_26460	COG0138	bifunctional purine biosynthesis protein purh
E6C67_26470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E6C67_26470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E6C67_26480	COG1024	Enoyl-CoA hydratase
E6C67_26485	COG0477	Major facilitator Superfamily
E6C67_26490	COG0583	DNA-binding transcription factor activity
E6C67_26510	COG1272	protein, Hemolysin III
E6C67_26545	COG0137	argininosuccinate synthase activity
E6C67_26550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E6C67_26555	COG0840	transmembrane signaling receptor activity
E6C67_26565	COG0783	Belongs to the Dps family
E6C67_26595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C67_26610	COG0776	regulation of translation
E6C67_26620	COG2423	ornithine cyclodeaminase activity
E6C67_26800	COG0741	lytic transglycosylase activity
E6C67_26950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E6C67_26990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E6C67_27005	COG3813	Protein conserved in bacteria
E6C67_27010	COG1473	amidohydrolase
E6C67_27020	COG5001	Diguanylate cyclase
E6C67_27060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E6C67_27080	COG3162	membrane
E6C67_27110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E6C67_27115	COG0542	response to heat
E6C67_27135	COG2890	protein-(glutamine-N5) methyltransferase activity
E6C67_27140	COG2852	Protein conserved in bacteria
E6C67_27150	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E6C67_27155	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E6C67_27205	COG0739	heme binding
E6C67_27225	COG0386	Belongs to the glutathione peroxidase family
E6C67_27230	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E6C67_27240	COG2985	domain, Protein
E6C67_27240	COG0569	domain protein
E6C67_27270	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E6C67_27275	COG0792	nuclease activity
E6C67_27290	COG0180	Tryptophanyl-tRNA synthetase
E6C67_27295	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
E6C67_27315	COG0606	chelatase, subunit chli
E6C67_27325	COG1420	regulation of RNA biosynthetic process
E6C67_27335	COG0745	RESPONSE REGULATOR receiver
E6C67_27340	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E6C67_27350	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E6C67_27365	COG0730	response to heat
E6C67_27380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E6C67_27390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E6C67_27405	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E6C67_27425	COG0668	transmembrane transport
E6C67_27430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E6C67_27440	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E6C67_27445	COG0302	gtp cyclohydrolase
E6C67_27450	COG2967	ApaG domain
E6C67_27460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E6C67_27465	COG1702	phosphate starvation-inducible protein PhoH
E6C67_27475	COG1253	flavin adenine dinucleotide binding
E6C67_27480	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E6C67_27485	COG1396	sequence-specific DNA binding
E6C67_27490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E6C67_27495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E6C67_27500	COG0779	Required for maturation of 30S ribosomal subunits
E6C67_27525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E6C67_27530	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E6C67_27535	COG1185	polyribonucleotide nucleotidyltransferase activity
E6C67_27540	COG2378	regulation of single-species biofilm formation
E6C67_27555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E6C67_27565	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E6C67_27570	COG1138	Cytochrome C-type biogenesis protein
E6C67_27575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E6C67_27580	COG3088	subunit of a heme lyase
E6C67_27585	COG4235	cytochrome complex assembly
E6C67_27645	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E6C67_27650	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E6C67_27655	COG4395	Tim44
E6C67_27665	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E6C67_27670	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E6C67_27680	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E6C67_27710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E6C67_27725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E6C67_27730	COG1331	Highly conserved protein containing a thioredoxin domain
E6C67_27750	COG0445	tRNA wobble uridine modification
E6C67_27755	COG0357	Ribosomal RNA small subunit methyltransferase G
E6C67_27760	COG1192	Involved in chromosome partitioning
E6C67_27765	COG1475	DNA binding
E6C67_27770	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E6C67_27775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E6C67_27780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E6C67_27785	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E6C67_27790	COG2814	Major facilitator Superfamily
E6C67_27795	COG0281	malic enzyme
E6C67_27795	COG0280	phosphate acetyltransferase
E6C67_27810	COG5002	protein histidine kinase activity
E6C67_27815	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E6C67_27820	COG0573	inorganic phosphate transmembrane transporter activity
E6C67_27830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E6C67_27835	COG0745	RESPONSE REGULATOR receiver
E6C67_27845	COG0670	Belongs to the BI1 family
E6C67_27855	COG4181	ATPase activity
E6C67_27870	COG0667	Aldo Keto reductase
E6C67_27875	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E6C67_27880	COG3706	GGDEF domain
E6C67_27885	COG0484	heat shock protein binding
E6C67_27890	COG0443	Heat shock 70 kDa protein
E6C67_27910	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E6C67_27930	COG4957	zinc ion binding
E6C67_27980	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E6C67_27990	COG0745	RESPONSE REGULATOR receiver
E6C67_27995	COG0642	Histidine kinase
E6C67_28015	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C67_28015	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E6C67_28025	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E6C67_28040	COG4783	chaperone-mediated protein folding
E6C67_28045	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
E6C67_28075	COG0271	Belongs to the BolA IbaG family
E6C67_28100	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E6C67_28120	COG4974	Belongs to the 'phage' integrase family
E6C67_28130	COG2154	pterin-4-alpha-carbinolamine dehydratase
E6C67_28140	COG1573	uracil-dna glycosylase
E6C67_28150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E6C67_28155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_28170	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E6C67_28175	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E6C67_28180	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E6C67_28210	COG2223	nitrite transmembrane transporter activity
E6C67_28240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E6C67_28240	COG0517	IMP dehydrogenase activity
E6C67_28255	COG1137	ATPase activity
E6C67_28260	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E6C67_28265	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E6C67_28270	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E6C67_28275	COG4636	protein conserved in cyanobacteria
E6C67_28285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E6C67_28290	COG0527	aspartate kinase activity
E6C67_28295	COG2070	2-Nitropropane dioxygenase
E6C67_28340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C67_28365	COG0501	Belongs to the peptidase M48B family
E6C67_28370	COG3258	Cytochrome c
E6C67_28375	COG0187	DNA topoisomerase II activity
E6C67_28380	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E6C67_28385	COG0592	DNA-directed DNA polymerase activity
E6C67_28405	COG3118	belongs to the thioredoxin family
E6C67_28410	COG1074	ATP-dependent DNA helicase activity
E6C67_28425	COG2887	Belongs to the helicase family. UvrD subfamily
E6C67_28430	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E6C67_28440	COG0802	atpase or kinase
E6C67_28455	COG2205	protein histidine kinase activity
E6C67_28465	COG0756	dUTP diphosphatase activity
E6C67_28470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E6C67_28475	COG2204	response regulator
E6C67_28480	COG1278	Cold shock
E6C67_28485	COG0784	Response regulator, receiver
E6C67_28485	COG2205	protein histidine kinase activity
E6C67_28490	COG0133	tryptophan synthase activity
E6C67_28500	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E6C67_28505	COG0285	dihydrofolate synthase activity
E6C67_28510	COG1715	Restriction endonuclease
E6C67_28525	COG1872	DUF167
E6C67_28530	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E6C67_28535	COG0598	Magnesium transport protein CorA
E6C67_28545	COG0039	L-malate dehydrogenase activity
E6C67_28560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E6C67_28565	COG4166	transmembrane transport
E6C67_28570	COG0747	negative chemotaxis
E6C67_28595	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E6C67_28630	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E6C67_28640	COG1024	Enoyl-CoA hydratase
E6C67_28645	COG0268	Binds directly to 16S ribosomal RNA
E6C67_28650	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E6C67_28655	COG3706	GGDEF domain
E6C67_28660	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E6C67_28665	COG3842	ATPase activity
E6C67_28675	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E6C67_28685	COG3385	transposase activity
E6C67_28695	COG0745	RESPONSE REGULATOR receiver
E6C67_28705	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E6C67_28725	COG2270	Major facilitator Superfamily
E6C67_28730	COG2264	protein methyltransferase activity
E6C67_28735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E6C67_28770	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E6C67_28860	COG0406	alpha-ribazole phosphatase activity
E6C67_28880	COG0745	RESPONSE REGULATOR receiver
E6C67_28960	COG1509	lysine 2,3-aminomutase activity
E6C67_28965	COG0584	glycerophosphoryl diester phosphodiesterase
E6C67_28990	COG2205	protein histidine kinase activity
E6C67_28990	COG2202	Pas domain
E6C67_29005	COG3162	membrane
E6C67_29020	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_29035	COG1960	acyl-CoA dehydrogenase activity
E6C67_29040	COG1187	pseudouridine synthase activity
E6C67_29050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E6C67_29060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E6C67_29065	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E6C67_29070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E6C67_29095	COG3437	response regulator, receiver
E6C67_29095	COG0784	Response regulator, receiver
E6C67_29105	COG0583	DNA-binding transcription factor activity
E6C67_29115	COG0252	asparaginase activity
E6C67_29135	COG0297	glycogen (starch) synthase activity
E6C67_29145	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
E6C67_29150	COG0004	ammonium transporteR
E6C67_29155	COG1741	Belongs to the pirin family
E6C67_29165	COG0753	catalase activity
E6C67_29180	COG2313	pseudouridylate synthase activity
E6C67_29190	COG1793	dna ligase
E6C67_29210	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_29220	COG0840	transmembrane signaling receptor activity
E6C67_29240	COG0135	phosphoribosylanthranilate isomerase activity
E6C67_29245	COG3706	GGDEF domain
E6C67_29245	COG0745	RESPONSE REGULATOR receiver
E6C67_29255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E6C67_29265	COG0156	8-amino-7-oxononanoate synthase activity
E6C67_29280	COG1176	ABC-type spermidine putrescine transport system, permease component I
E6C67_29285	COG1177	transmembrane transport
E6C67_29305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E6C67_29315	COG3278	Belongs to the heme-copper respiratory oxidase family
E6C67_29350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E6C67_29355	COG1612	heme a metabolic process
E6C67_29360	COG3772	lysozyme
E6C67_29365	COG5425	PFAM Usg family protein
E6C67_29370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E6C67_29375	COG0459	protein refolding
E6C67_29390	COG4566	intracellular signal transduction
E6C67_29405	COG0604	alcohol dehydrogenase
E6C67_29410	COG0583	DNA-binding transcription factor activity
E6C67_29430	COG4608	Belongs to the ABC transporter superfamily
E6C67_29435	COG0444	Belongs to the ABC transporter superfamily
E6C67_29445	COG0601	transmembrane transport
E6C67_29455	COG0492	ferredoxin-NADP+ reductase activity
E6C67_29465	COG1695	Transcriptional regulator
E6C67_29480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E6C67_29490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E6C67_29505	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E6C67_29510	COG1595	DNA-templated transcription, initiation
E6C67_29535	COG2205	protein histidine kinase activity
E6C67_29535	COG2202	Pas domain
E6C67_29575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E6C67_29580	COG0825	malonyl-CoA metabolic process
E6C67_29590	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E6C67_29595	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E6C67_29600	COG1842	Phage shock protein A
E6C67_29620	COG1216	Glycosyl transferase, family 2
E6C67_29620	COG1442	glycosyl transferase family 8
E6C67_29650	COG0181	hydroxymethylbilane synthase activity
E6C67_29660	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E6C67_29685	COG0587	DNA-directed DNA polymerase activity
E6C67_29705	COG0784	Response regulator, receiver
E6C67_29705	COG3437	response regulator, receiver
E6C67_29710	COG3158	transport of potassium into the cell
E6C67_29725	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E6C67_29730	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E6C67_29735	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E6C67_29740	COG0842	Transport permease protein
E6C67_29745	COG2137	regulation of response to DNA damage stimulus
E6C67_29750	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E6C67_29760	COG1703	isobutyryl-CoA mutase activity
E6C67_29765	COG4172	Belongs to the ABC transporter superfamily
E6C67_29775	COG4239	(ABC) transporter, permease
E6C67_29780	COG4174	ABC transporter (Permease)
E6C67_29785	COG4166	transmembrane transport
E6C67_29790	COG4166	transmembrane transport
E6C67_29815	COG0077	Prephenate dehydratase
E6C67_29825	COG3474	cytochrome
E6C67_29840	COG2766	serine protein kinase
E6C67_29845	COG2718	Belongs to the UPF0229 family
E6C67_29855	COG2719	SpoVR family
E6C67_29875	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_29880	COG1254	Belongs to the acylphosphatase family
E6C67_29905	COG0671	phosphoesterase, PA-phosphatase related
E6C67_29915	COG2239	Acts as a magnesium transporter
E6C67_29920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E6C67_29920	COG2022	thiamine diphosphate biosynthetic process
E6C67_29930	COG2022	thiamine diphosphate biosynthetic process
E6C67_30015	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E6C67_30020	COG3108	Peptidase M15
E6C67_30030	COG3038	cytochrome b561
E6C67_30040	COG0642	Histidine kinase
E6C67_30045	COG0745	RESPONSE REGULATOR receiver
E6C67_30055	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E6C67_30060	COG0277	FAD linked oxidase domain protein
E6C67_30065	COG0277	FAD linked oxidase domain protein
E6C67_30070	COG0247	lactate metabolic process
E6C67_30095	COG1454	alcohol dehydrogenase
E6C67_30110	COG1960	acyl-CoA dehydrogenase activity
E6C67_30130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E6C67_30135	COG2171	N-acyltransferase activity
E6C67_30170	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E6C67_30175	COG0228	four-way junction DNA binding
E6C67_30180	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E6C67_30185	COG0336	Belongs to the RNA methyltransferase TrmD family
E6C67_30190	COG0335	large ribosomal subunit rRNA binding
E6C67_30195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E6C67_30205	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E6C67_30210	COG0706	membrane insertase activity
E6C67_30215	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E6C67_30225	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E6C67_30240	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E6C67_30250	COG1530	ribonuclease E activity
E6C67_30255	COG0860	N-Acetylmuramoyl-L-alanine amidase
E6C67_30290	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E6C67_30290	COG0561	phosphatase activity
E6C67_30325	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E6C67_30330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_30335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_30365	COG0411	ABC transporter
E6C67_30420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E6C67_30440	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E6C67_30445	COG0081	regulation of translation
E6C67_30450	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E6C67_30460	COG0085	RNA polymerase activity
E6C67_30465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E6C67_30475	COG0049	tRNA binding
E6C67_30485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E6C67_30490	COG0051	transcription antitermination factor activity, RNA binding
E6C67_30500	COG0088	Forms part of the polypeptide exit tunnel
E6C67_30505	COG0089	rRNA binding
E6C67_30510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E6C67_30515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E6C67_30520	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E6C67_30525	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E6C67_30530	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E6C67_30535	COG0255	Belongs to the universal ribosomal protein uL29 family
E6C67_30540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E6C67_30550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E6C67_30560	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E6C67_30565	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E6C67_30570	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E6C67_30580	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E6C67_30585	COG1841	ribosomal large subunit assembly
E6C67_30590	COG0200	Binds to the 23S rRNA
E6C67_30600	COG0563	adenylate kinase activity
E6C67_30610	COG0697	spore germination
E6C67_30625	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E6C67_30635	COG2267	carboxylic ester hydrolase activity
E6C67_30645	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E6C67_30675	COG1285	pathogenesis
E6C67_30680	COG2814	Major facilitator Superfamily
E6C67_30685	COG0196	riboflavin kinase activity
E6C67_30690	COG2030	dehydratase
E6C67_30695	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E6C67_30710	COG0628	permease
E6C67_30740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E6C67_30745	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E6C67_30755	COG1597	lipid kinase activity
E6C67_30765	COG0438	transferase activity, transferring glycosyl groups
E6C67_30770	COG1280	lysine exporter protein (LysE YggA)
E6C67_30775	COG1519	Transferase
E6C67_30780	COG1663	tetraacyldisaccharide 4'-kinase activity
E6C67_30800	COG5002	protein histidine kinase activity
E6C67_30800	COG0784	Response regulator, receiver
E6C67_30800	COG2205	protein histidine kinase activity
E6C67_30810	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E6C67_30815	COG0644	oxidoreductase
E6C67_30870	COG1902	pentaerythritol trinitrate reductase activity
E6C67_30880	COG2962	Rard protein
E6C67_30895	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E6C67_30905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E6C67_30920	COG2205	protein histidine kinase activity
E6C67_30935	COG0395	ABC-type sugar transport system, permease component
E6C67_30945	COG5508	conserved small protein
E6C67_30955	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E6C67_30985	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E6C67_30995	COG4584	PFAM Integrase catalytic
E6C67_31000	COG1484	DNA-dependent DNA replication
E6C67_31005	COG4584	PFAM Integrase catalytic
E6C67_31005	COG2390	Transcriptional regulator
E6C67_31010	COG1484	DNA-dependent DNA replication
E6C67_31015	COG2433	Pfam Transposase IS66
E6C67_31020	COG3436	PFAM IS66 Orf2 family protein
E6C67_31095	COG3852	Histidine kinase
E6C67_31100	COG1366	Belongs to the anti-sigma-factor antagonist family
E6C67_31125	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E6C67_31150	COG1686	Belongs to the peptidase S11 family
E6C67_31165	COG2205	protein histidine kinase activity
E6C67_31165	COG2202	Pas domain
E6C67_31170	COG5002	protein histidine kinase activity
E6C67_31175	COG2205	protein histidine kinase activity
E6C67_31185	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E6C67_31205	COG0166	Belongs to the GPI family
E6C67_31215	COG0612	Peptidase, M16
E6C67_31255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E6C67_31260	COG2703	oxygen carrier activity
E6C67_31265	COG0840	transmembrane signaling receptor activity
E6C67_31275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E6C67_31290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E6C67_31300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E6C67_31320	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E6C67_31325	COG0746	molybdenum cofactor guanylyltransferase activity
E6C67_31350	COG0243	molybdopterin cofactor binding
E6C67_31350	COG3383	formate dehydrogenase (NAD+) activity
E6C67_31355	COG0437	4 iron, 4 sulfur cluster binding
E6C67_31370	COG0235	Class ii aldolase
E6C67_31375	COG5002	protein histidine kinase activity
E6C67_31375	COG0784	Response regulator, receiver
E6C67_31380	COG3384	dioxygenase
E6C67_31385	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E6C67_31390	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E6C67_31395	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E6C67_31400	COG0356	it plays a direct role in the translocation of protons across the membrane
E6C67_31410	COG1999	signal sequence binding
E6C67_31415	COG0840	transmembrane signaling receptor activity
E6C67_31420	COG1702	phosphate starvation-inducible protein PhoH
E6C67_31425	COG0850	regulation of cytokinetic process
E6C67_31430	COG2894	cell division
E6C67_31435	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E6C67_31460	COG4948	Mandelate Racemase Muconate Lactonizing
E6C67_31470	COG1573	uracil-dna glycosylase
E6C67_31475	COG2264	protein methyltransferase activity
E6C67_31500	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E6C67_31510	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
E6C67_31515	COG5420	small protein containing a coiled-coil domain
E6C67_31530	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
E6C67_31535	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
E6C67_31580	COG0121	glutamine amidotransferase
E6C67_31590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E6C67_31595	COG0552	protein localization to endoplasmic reticulum
E6C67_31600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E6C67_31605	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E6C67_31640	COG2301	Belongs to the HpcH HpaI aldolase family
E6C67_31645	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E6C67_31650	COG2205	protein histidine kinase activity
E6C67_31655	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E6C67_31660	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E6C67_31675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E6C67_31680	COG1063	alcohol dehydrogenase
E6C67_31690	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C67_31690	COG0596	Alpha beta hydrolase
E6C67_31695	COG0022	dehydrogenase e1 component
E6C67_31700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E6C67_31705	COG3199	ATP-NAD kinase
E6C67_31710	COG0277	FAD linked oxidase domain protein
E6C67_31715	COG1671	Belongs to the UPF0178 family
E6C67_31720	COG0488	(ABC) transporter
E6C67_31745	COG2853	Lipoprotein
E6C67_31770	COG0646	methionine synthase
E6C67_31770	COG1410	methionine synthase
E6C67_31800	COG3706	GGDEF domain
E6C67_31805	COG2070	2-Nitropropane dioxygenase
E6C67_31820	COG0488	(ABC) transporter
E6C67_31825	COG2814	Major facilitator Superfamily
E6C67_31840	COG0175	sulfate reduction
E6C67_31845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E6C67_31845	COG1648	precorrin-2 dehydrogenase activity
E6C67_31855	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E6C67_31870	COG3108	Peptidase M15
E6C67_31880	COG2205	protein histidine kinase activity
E6C67_31880	COG2202	Pas domain
E6C67_31885	COG4566	intracellular signal transduction
E6C67_31910	COG0243	molybdopterin cofactor binding
E6C67_31920	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
E6C67_31920	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E6C67_31935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E6C67_31945	COG0612	Peptidase, M16
E6C67_31950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E6C67_31975	COG0483	inositol monophosphate 1-phosphatase activity
E6C67_31980	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E6C67_31995	COG0730	response to heat
E6C67_32000	COG0352	thiamine-phosphate diphosphorylase activity
E6C67_32005	COG1830	Aldolase
E6C67_32025	COG0840	transmembrane signaling receptor activity
E6C67_32055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E6C67_32060	COG1692	metallophosphoesterase
E6C67_32065	COG0217	transcriptional regulatory protein
E6C67_32075	COG0632	four-way junction helicase activity
E6C67_32080	COG2255	four-way junction helicase activity
E6C67_32085	COG0824	Thioesterase
E6C67_32095	COG0848	biopolymer transport protein
E6C67_32110	COG2885	chlorophyll binding
E6C67_32125	COG0037	tRNA processing
E6C67_32130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E6C67_32150	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E6C67_32155	COG1295	ribonuclease BN
E6C67_32160	COG3385	transposase activity
E6C67_32175	COG0259	pyridoxamine-phosphate oxidase activity
E6C67_32185	COG0840	transmembrane signaling receptor activity
E6C67_32205	COG2153	protein acetylation
E6C67_32220	COG3685	Protein conserved in bacteria
E6C67_32235	COG4957	zinc ion binding
E6C67_32240	COG0698	ribose 5-phosphate isomerase
E6C67_32245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E6C67_32250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E6C67_32255	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E6C67_32270	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E6C67_32275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E6C67_32280	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E6C67_32280	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E6C67_32290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E6C67_32290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E6C67_32310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E6C67_32315	COG0416	fatty acid biosynthetic process
E6C67_32320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E6C67_32370	COG0811	peptide transport
E6C67_32375	COG0848	biopolymer transport protein
E6C67_32390	COG4774	siderophore transport
E6C67_32395	COG1764	response to oxidative stress
E6C67_32400	COG1846	Transcriptional regulator
E6C67_32405	COG0456	acetyltransferase
E6C67_32415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E6C67_32420	COG1393	Belongs to the ArsC family
E6C67_32425	COG2890	protein-(glutamine-N5) methyltransferase activity
E6C67_32435	COG1403	HNH endonuclease
E6C67_32465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E6C67_32485	COG4591	ABC-type transport system involved in lipoprotein release permease component
E6C67_32485	COG1136	(ABC) transporter
E6C67_32525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E6C67_32550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E6C67_32560	COG3108	Peptidase M15
E6C67_32585	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E6C67_32590	COG0511	ligase activity, forming carbon-carbon bonds
E6C67_32595	COG0439	Biotin carboxylase
E6C67_32600	COG0840	transmembrane signaling receptor activity
E6C67_32605	COG4251	negative regulation of phosphorylation
E6C67_32610	COG4251	negative regulation of phosphorylation
E6C67_32615	COG0784	Response regulator, receiver
E6C67_32620	COG0745	RESPONSE REGULATOR receiver
E6C67_32620	COG3706	GGDEF domain
E6C67_32630	COG0745	RESPONSE REGULATOR receiver
E6C67_32650	COG0432	Pfam Uncharacterised protein family UPF0047
E6C67_32665	COG2205	protein histidine kinase activity
E6C67_32670	COG0628	permease
E6C67_32680	COG3385	transposase activity
E6C67_32685	COG0616	signal peptide processing
E6C67_32695	COG0745	RESPONSE REGULATOR receiver
E6C67_32710	COG0840	transmembrane signaling receptor activity
E6C67_32715	COG0436	Aminotransferase
E6C67_32725	COG1494	fructose-1,6-bisphosphatase
E6C67_32745	COG1324	tolerance protein
E6C67_32750	COG0303	'Molybdopterin
E6C67_32755	COG0583	DNA-binding transcription factor activity
E6C67_32760	COG2373	Large extracellular alpha-helical protein
E6C67_32765	COG4953	penicillin-binding protein 1C
E6C67_32780	COG2132	Multicopper oxidase
E6C67_32790	COG4636	protein conserved in cyanobacteria
E6C67_32795	COG0494	nUDIX hydrolase
E6C67_32800	COG0024	Methionine aminopeptidase
E6C67_32820	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E6C67_32825	COG4221	oxidoreductase activity
E6C67_32830	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E6C67_32855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E6C67_32890	COG0473	3-isopropylmalate dehydrogenase activity
E6C67_32915	COG0330	HflC and HflK could
E6C67_32925	COG0538	isocitrate dehydrogenase activity
E6C67_32930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E6C67_32935	COG0359	binds to the 23S rRNA
E6C67_32945	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E6C67_32950	COG0360	Binds together with S18 to 16S ribosomal RNA
E6C67_32960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E6C67_32975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E6C67_32980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E6C67_32995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E6C67_33040	COG3437	response regulator, receiver
E6C67_33040	COG0784	Response regulator, receiver
E6C67_33055	COG4191	Histidine kinase
E6C67_33055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_33085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_33095	COG1607	acyl-coa hydrolase
E6C67_33100	COG0187	DNA topoisomerase II activity
E6C67_33135	COG0513	Belongs to the DEAD box helicase family
E6C67_33155	COG0840	transmembrane signaling receptor activity
E6C67_33170	COG1561	YicC-like family, N-terminal region
E6C67_33185	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E6C67_33190	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E6C67_33195	COG0052	Belongs to the universal ribosomal protein uS2 family
E6C67_33200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E6C67_33205	COG0528	UMP kinase activity
E6C67_33210	COG0233	cytoplasmic translational termination
E6C67_33215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E6C67_33220	COG0575	Belongs to the CDS family
E6C67_33225	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E6C67_33230	COG0750	zinc metalloprotease
E6C67_33250	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E6C67_33255	COG3494	Protein of unknown function (DUF1009)
E6C67_33260	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E6C67_33270	COG4977	sequence-specific DNA binding
E6C67_33275	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E6C67_33290	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E6C67_33295	COG0658	competence protein
E6C67_33295	COG2333	competence protein COMEC
E6C67_33300	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E6C67_33305	COG0303	'Molybdopterin
E6C67_33310	COG0315	cyclic pyranopterin monophosphate synthase activity
E6C67_33375	COG1492	cobalamin metabolic process
E6C67_33390	COG2897	thiosulfate sulfurtransferase activity
E6C67_33405	COG0494	nUDIX hydrolase
E6C67_33410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C67_33440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E6C67_33450	COG1538	Outer membrane efflux protein
E6C67_33460	COG0525	valine-tRNA ligase activity
E6C67_33465	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E6C67_33470	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E6C67_33480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E6C67_33485	COG0628	permease
E6C67_33495	COG0300	oxidoreductase activity
E6C67_33500	COG1846	Transcriptional regulator
E6C67_33505	COG0124	histidyl-tRNA synthetase
E6C67_33540	COG1396	sequence-specific DNA binding
E6C67_33580	COG0704	Plays a role in the regulation of phosphate uptake
E6C67_33595	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E6C67_33600	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
E6C67_33605	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
E6C67_33625	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E6C67_33630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E6C67_33665	COG1366	Belongs to the anti-sigma-factor antagonist family
E6C67_33670	COG2208	phosphoserine phosphatase activity
E6C67_33680	COG0784	Response regulator, receiver
E6C67_33680	COG5002	protein histidine kinase activity
E6C67_33680	COG2205	protein histidine kinase activity
E6C67_33685	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E6C67_33710	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_33715	COG0443	Heat shock 70 kDa protein
E6C67_33720	COG0489	protein tyrosine kinase activity
E6C67_33725	COG0330	HflC and HflK could
E6C67_33730	COG0330	HflC and HflK could
E6C67_33735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E6C67_33740	COG2197	response regulator
E6C67_33745	COG2205	protein histidine kinase activity
E6C67_33750	COG0745	RESPONSE REGULATOR receiver
E6C67_33760	COG1846	Transcriptional regulator
E6C67_33770	COG0149	triose-phosphate isomerase activity
E6C67_33795	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E6C67_33805	COG1566	PFAM secretion protein HlyD family protein
E6C67_33810	COG1136	(ABC) transporter
E6C67_33815	COG1136	(ABC) transporter
E6C67_33815	COG0577	efflux transmembrane transporter activity
E6C67_33845	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E6C67_33850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E6C67_33855	COG0534	Mate efflux family protein
E6C67_33875	COG0741	lytic transglycosylase activity
E6C67_33880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E6C67_33885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E6C67_33890	COG2813	Specifically methylates the guanine in position
E6C67_33895	COG0667	Aldo Keto reductase
E6C67_33910	COG1881	PFAM PEBP family protein
E6C67_33915	COG0113	porphobilinogen synthase activity
E6C67_33930	COG1024	Enoyl-CoA hydratase
E6C67_33935	COG1846	Transcriptional regulator
E6C67_33950	COG0559	Belongs to the binding-protein-dependent transport system permease family
E6C67_33965	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E6C67_33975	COG2264	protein methyltransferase activity
E6C67_33990	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_34000	COG0456	acetyltransferase
E6C67_34005	COG0058	SHG alpha-glucan phosphorylase activity
E6C67_34010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E6C67_34015	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E6C67_34020	COG4191	Histidine kinase
E6C67_34025	COG0745	RESPONSE REGULATOR receiver
E6C67_34030	COG1305	Transglutaminase-like
E6C67_34035	COG2308	Evidence 4 Homologs of previously reported genes of
E6C67_34035	COG2307	Protein conserved in bacteria
E6C67_34040	COG2010	Cytochrome c
E6C67_34060	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_34070	COG0583	DNA-binding transcription factor activity
E6C67_34085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E6C67_34100	COG3784	Protein of unknown function (DUF1318)
E6C67_34130	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
E6C67_34135	COG2814	Major facilitator Superfamily
E6C67_34140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E6C67_34150	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E6C67_34170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E6C67_34180	COG3737	Protein of unknown function (DUF498/DUF598)
E6C67_34185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E6C67_34190	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
E6C67_34195	COG1562	ergosterol biosynthetic process
E6C67_34200	COG1562	ergosterol biosynthetic process
E6C67_34230	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E6C67_34245	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E6C67_34255	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_34265	COG0617	tRNA 3'-terminal CCA addition
E6C67_34280	COG0714	Associated with various cellular activities
E6C67_34320	COG4584	PFAM Integrase catalytic
E6C67_34320	COG2390	Transcriptional regulator
E6C67_34325	COG1484	DNA-dependent DNA replication
E6C67_34330	COG1484	DNA-dependent DNA replication
E6C67_34335	COG4584	PFAM Integrase catalytic
E6C67_34375	COG2226	methyltransferase
E6C67_34380	COG2814	Major facilitator Superfamily
E6C67_34385	COG0583	DNA-binding transcription factor activity
E6C67_34390	COG0629	single-stranded DNA binding
E6C67_34420	COG0123	including yeast histone deacetylase and acetoin utilization protein
E6C67_34425	COG1116	anion transmembrane transporter activity
E6C67_34430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_34435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E6C67_34445	COG0483	inositol monophosphate 1-phosphatase activity
E6C67_34460	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E6C67_34465	COG1923	regulation of RNA biosynthetic process
E6C67_34475	COG2204	response regulator
E6C67_34515	COG1942	4-Oxalocrotonate Tautomerase
E6C67_34520	COG2867	negative regulation of translational initiation
E6C67_34525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E6C67_34535	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E6C67_34545	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C67_34550	COG0508	dehydrogenase complex catalyzes the overall conversion of
E6C67_34550	COG0022	dehydrogenase e1 component
E6C67_34555	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E6C67_34575	COG4149	molybdate abc transporter
E6C67_34580	COG0725	ABC transporter, periplasmic molybdate-binding protein
E6C67_34585	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E6C67_34595	COG2261	transglycosylase associated protein
E6C67_34610	COG2135	peptidase activity
E6C67_34620	COG3287	FIST C domain
E6C67_34620	COG2200	EAL domain
E6C67_34620	COG2199	diguanylate cyclase activity
E6C67_34630	COG1218	3'(2'),5'-bisphosphate nucleotidase
E6C67_34635	COG2833	Protein of unknown function (DUF455)
E6C67_34640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E6C67_34645	COG0328	RNA-DNA hybrid ribonuclease activity
E6C67_34650	COG0678	peroxiredoxin activity
E6C67_34655	COG2824	Alkylphosphonate utilization operon protein PhnA
E6C67_34660	COG4232	protein-disulfide reductase activity
E6C67_34665	COG1678	Uncharacterized ACR, COG1678
E6C67_34670	COG0314	molybdopterin synthase activity
E6C67_34675	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E6C67_34685	COG0546	phosphoglycolate phosphatase activity
E6C67_34690	COG1763	Mo-molybdopterin cofactor biosynthetic process
E6C67_34695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E6C67_34705	COG1028	Short-chain dehydrogenase reductase Sdr
E6C67_34730	COG4120	Belongs to the binding-protein-dependent transport system permease family
E6C67_34735	COG0410	ABC transporter
E6C67_34745	COG0672	)-iron permease
E6C67_34760	COG0640	Transcriptional regulator
E6C67_34780	COG0583	DNA-binding transcription factor activity
E6C67_34785	COG0540	Belongs to the ATCase OTCase family
E6C67_34790	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E6C67_34800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E6C67_34820	COG0776	regulation of translation
E6C67_34825	COG4957	zinc ion binding
E6C67_34830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E6C67_34860	COG0741	lytic transglycosylase activity
E6C67_34865	COG0556	nucleotide-excision repair
E6C67_34890	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E6C67_34895	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E6C67_34915	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E6C67_34925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E6C67_34930	COG1126	abc transporter atp-binding protein
E6C67_34935	COG0765	amino acid transport
E6C67_34940	COG4597	amino acid ABC transporter
E6C67_34945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E6C67_34950	COG0626	cystathionine gamma-synthase activity
E6C67_35005	COG2308	Evidence 4 Homologs of previously reported genes of
E6C67_35010	COG1360	Flagellar Motor Protein
E6C67_35015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E6C67_35035	COG0318	PFAM AMP-dependent synthetase and ligase
E6C67_35040	COG0789	Transcriptional regulator
E6C67_35050	COG2086	electron transfer activity
E6C67_35070	COG2205	protein histidine kinase activity
E6C67_35075	COG0728	peptidoglycan biosynthetic process
E6C67_35080	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
E6C67_35100	COG1765	OsmC-like protein
E6C67_35105	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E6C67_35115	COG5487	UPF0391 membrane protein
E6C67_35125	COG1196	nuclear chromosome segregation
E6C67_35125	COG0739	heme binding
E6C67_35125	COG0741	lytic transglycosylase activity
E6C67_35140	COG2226	methyltransferase
E6C67_35160	COG1178	ABC-type Fe3 transport system permease component
E6C67_35180	COG1752	Esterase of the alpha-beta hydrolase superfamily
E6C67_35185	COG1132	(ABC) transporter
E6C67_35190	COG3842	ATPase activity
E6C67_35195	COG1840	ABC-type Fe3 transport system, periplasmic component
E6C67_35200	COG5001	Diguanylate cyclase
E6C67_35210	COG1742	UPF0060 membrane protein
E6C67_35220	COG3237	CsbD-like
E6C67_35225	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E6C67_35230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E6C67_35240	COG3346	SURF1 family
E6C67_35250	COG1845	cytochrome c oxidase, subunit III
E6C67_35255	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E6C67_35265	COG0109	protoheme IX farnesyltransferase activity
E6C67_35270	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E6C67_35275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E6C67_35285	COG0312	modulator of DNA gyrase
E6C67_35305	COG2076	Multidrug Resistance protein
E6C67_35315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E6C67_35355	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E6C67_35365	COG1987	bacterial-type flagellum assembly
E6C67_35370	COG1677	Flagellar hook-basal body complex protein FliE
E6C67_35375	COG1558	bacterial-type flagellum-dependent cell motility
E6C67_35380	COG1815	bacterial-type flagellum-dependent cell motility
E6C67_35385	COG2257	FlhB HrpN YscU SpaS Family
E6C67_35400	COG1338	Plays a role in the flagellum-specific transport system
E6C67_35410	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E6C67_35420	COG1360	Flagellar Motor Protein
E6C67_35435	COG1752	Esterase of the alpha-beta hydrolase superfamily
E6C67_35445	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E6C67_35460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E6C67_35470	COG0571	ribonuclease III activity
E6C67_35475	COG0681	Belongs to the peptidase S26 family
E6C67_35480	COG0736	holo-[acyl-carrier-protein] synthase activity
E6C67_35485	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E6C67_35495	COG1758	RNA polymerase activity
E6C67_35505	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E6C67_35510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E6C67_35560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E6C67_35590	COG0640	Transcriptional regulator
E6C67_35600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_35645	COG4372	Transposase
E6C67_35650	COG3436	PFAM IS66 Orf2 family protein
E6C67_35675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E6C67_35690	COG0583	DNA-binding transcription factor activity
E6C67_35720	COG3436	PFAM IS66 Orf2 family protein
E6C67_35745	COG1475	DNA binding
E6C67_35765	COG1396	sequence-specific DNA binding
E6C67_35810	COG1475	DNA binding
E6C67_35925	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_35995	COG0681	Belongs to the peptidase S26 family
E6C67_36110	COG0501	Belongs to the peptidase M48B family
E6C67_36200	COG0583	DNA-binding transcription factor activity
E6C67_36205	COG1063	alcohol dehydrogenase
E6C67_36320	COG3437	response regulator, receiver
E6C67_36320	COG2770	Histidine kinase
E6C67_36335	COG1484	DNA-dependent DNA replication
E6C67_36340	COG4584	PFAM Integrase catalytic
E6C67_36510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E6C67_36515	COG4957	zinc ion binding
E6C67_36545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E6C67_36630	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E6C67_36635	COG1116	anion transmembrane transporter activity
E6C67_36640	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E6C67_36670	COG1937	Protein conserved in bacteria
E6C67_36675	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E6C67_36685	COG5002	protein histidine kinase activity
E6C67_36690	COG0586	Pfam SNARE associated Golgi protein
E6C67_36695	COG0671	phosphoesterase, PA-phosphatase related
E6C67_36700	COG0586	Pfam SNARE associated Golgi protein
E6C67_36720	COG3316	Transposase and inactivated derivatives
E6C67_36750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E6C67_36760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E6C67_36770	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E6C67_36785	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E6C67_36790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E6C67_36795	COG0583	DNA-binding transcription factor activity
E6C67_36820	COG0745	RESPONSE REGULATOR receiver
E6C67_36820	COG4566	intracellular signal transduction
E6C67_36825	COG2203	Gaf domain
E6C67_36825	COG2199	diguanylate cyclase activity
E6C67_36840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E6C67_36865	COG0348	domain, Protein
E6C67_36865	COG3901	Regulator of nitric oxide reductase transcription
E6C67_36890	COG0671	phosphoesterase, PA-phosphatase related
E6C67_36910	COG3436	PFAM IS66 Orf2 family protein
E6C67_36915	COG2433	Pfam Transposase IS66
E6C67_36920	COG4372	Transposase
E6C67_36950	COG2204	response regulator
E6C67_36995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E6C67_37075	COG0586	Pfam SNARE associated Golgi protein
E6C67_37080	COG0671	phosphoesterase, PA-phosphatase related
E6C67_37085	COG0586	Pfam SNARE associated Golgi protein
E6C67_37090	COG5002	protein histidine kinase activity
E6C67_37105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E6C67_37130	COG1937	Protein conserved in bacteria
E6C67_37145	COG0586	Pfam SNARE associated Golgi protein
E6C67_37150	COG0671	phosphoesterase, PA-phosphatase related
E6C67_37215	COG3258	Cytochrome c
E6C67_37240	COG2132	Multicopper oxidase
E6C67_37255	COG2205	protein histidine kinase activity
E6C67_37260	COG0745	RESPONSE REGULATOR receiver
E6C67_37265	COG0745	RESPONSE REGULATOR receiver