locus-tag	class	description
TSH58p_00025	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_00050	COG5002	protein histidine kinase activity
TSH58p_00050	COG2205	protein histidine kinase activity
TSH58p_00050	COG0784	Response regulator, receiver
TSH58p_00060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_00100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TSH58p_00105	COG4191	Histidine kinase
TSH58p_00110	COG4566	intracellular signal transduction
TSH58p_00120	COG0848	biopolymer transport protein
TSH58p_00160	COG3275	phosphorelay sensor kinase activity
TSH58p_00175	COG1966	Carbon starvation protein
TSH58p_00190	COG1363	Peptidase, m42
TSH58p_00195	COG2918	glutathione biosynthetic process
TSH58p_00195	COG1181	Belongs to the D-alanine--D-alanine ligase family
TSH58p_00200	COG0367	asparagine synthase
TSH58p_00245	COG1802	Transcriptional regulator
TSH58p_00250	COG2239	Acts as a magnesium transporter
TSH58p_00260	COG0861	Integral membrane protein TerC family
TSH58p_00330	COG2226	methyltransferase
TSH58p_00350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_00365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TSH58p_00370	COG1846	Transcriptional regulator
TSH58p_00380	COG1309	transcriptional regulator
TSH58p_00385	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_00390	COG2186	Transcriptional regulator
TSH58p_00395	COG1960	acyl-CoA dehydrogenase activity
TSH58p_00405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSH58p_00420	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_00440	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_00450	COG1960	acyl-CoA dehydrogenase activity
TSH58p_00455	COG0183	Belongs to the thiolase family
TSH58p_00460	COG1960	acyl-CoA dehydrogenase activity
TSH58p_00465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TSH58p_00470	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TSH58p_00505	COG2819	hydrolase of the alpha beta superfamily
TSH58p_00525	COG2723	6-phospho-beta-galactosidase activity
TSH58p_00530	COG2723	6-phospho-beta-galactosidase activity
TSH58p_00535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSH58p_00545	COG4178	(ABC) transporter
TSH58p_00555	COG1216	Glycosyl transferase, family 2
TSH58p_00555	COG1442	glycosyl transferase family 8
TSH58p_00580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TSH58p_00600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_00615	COG2197	response regulator
TSH58p_00625	COG0643	Histidine kinase
TSH58p_00625	COG2198	Histidine kinase
TSH58p_00630	COG0745	RESPONSE REGULATOR receiver
TSH58p_00630	COG3706	GGDEF domain
TSH58p_00635	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TSH58p_00645	COG2201	protein-glutamate methylesterase activity
TSH58p_00650	COG0835	chemotaxis
TSH58p_00655	COG0840	transmembrane signaling receptor activity
TSH58p_00670	COG2095	MarC family integral membrane protein
TSH58p_00695	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_00700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TSH58p_00715	COG0395	ABC-type sugar transport system, permease component
TSH58p_00725	COG3842	ATPase activity
TSH58p_00740	COG0586	Pfam SNARE associated Golgi protein
TSH58p_00760	COG4615	Cyclic peptide transporter
TSH58p_00795	COG0840	transmembrane signaling receptor activity
TSH58p_00825	COG5002	protein histidine kinase activity
TSH58p_00825	COG0784	Response regulator, receiver
TSH58p_00830	COG0784	Response regulator, receiver
TSH58p_00830	COG4191	Histidine kinase
TSH58p_00880	COG0668	transmembrane transport
TSH58p_00950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TSH58p_00955	COG1960	acyl-CoA dehydrogenase activity
TSH58p_00960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TSH58p_00965	COG1764	response to oxidative stress
TSH58p_01010	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_01035	COG0583	DNA-binding transcription factor activity
TSH58p_01065	COG1573	uracil-dna glycosylase
TSH58p_01090	COG2010	Cytochrome c
TSH58p_01130	COG1891	lyase activity
TSH58p_01150	COG1131	(ABC) transporter
TSH58p_01170	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
TSH58p_01175	COG1229	Formylmethanofuran dehydrogenase subunit A
TSH58p_01185	COG2154	pterin-4-alpha-carbinolamine dehydratase
TSH58p_01195	COG0702	epimerase
TSH58p_01210	COG0189	ligase activity
TSH58p_01220	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
TSH58p_01275	COG4566	intracellular signal transduction
TSH58p_01280	COG4191	Histidine kinase
TSH58p_01290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TSH58p_01325	COG0410	ABC transporter
TSH58p_01330	COG0411	ABC transporter
TSH58p_01335	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_01345	COG1024	Enoyl-CoA hydratase
TSH58p_01365	COG0183	Belongs to the thiolase family
TSH58p_01380	COG0410	ABC transporter
TSH58p_01390	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_01395	COG0683	leucine binding
TSH58p_01400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TSH58p_01405	COG0022	dehydrogenase e1 component
TSH58p_01405	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSH58p_01410	COG1024	Enoyl-CoA hydratase
TSH58p_01415	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSH58p_01440	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
TSH58p_01445	COG1595	DNA-templated transcription, initiation
TSH58p_01450	COG3712	iron ion homeostasis
TSH58p_01460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_01465	COG1136	(ABC) transporter
TSH58p_01465	COG0577	efflux transmembrane transporter activity
TSH58p_01480	COG1121	(ABC) transporter
TSH58p_01540	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_01545	COG4948	Mandelate Racemase Muconate Lactonizing
TSH58p_01550	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TSH58p_01555	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_01560	COG1802	Transcriptional regulator
TSH58p_01600	COG1595	DNA-templated transcription, initiation
TSH58p_01605	COG0110	maltose O-acetyltransferase activity
TSH58p_01610	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TSH58p_01630	COG2610	gluconate transmembrane transporter activity
TSH58p_01650	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TSH58p_01655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TSH58p_01660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSH58p_01665	COG3411	Ferredoxin
TSH58p_01750	COG1024	Enoyl-CoA hydratase
TSH58p_01760	COG3842	ATPase activity
TSH58p_01765	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_01770	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_01775	COG0840	transmembrane signaling receptor activity
TSH58p_01785	COG0427	acetyl-CoA hydrolase
TSH58p_01815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_01875	COG4178	(ABC) transporter
TSH58p_01885	COG1475	DNA binding
TSH58p_01890	COG1192	Involved in chromosome partitioning
TSH58p_01895	COG4783	chaperone-mediated protein folding
TSH58p_01915	COG3622	Belongs to the hyi family
TSH58p_01925	COG1215	transferase activity, transferring glycosyl groups
TSH58p_01940	COG3307	-O-antigen
TSH58p_01945	COG3206	protein involved in exopolysaccharide biosynthesis
TSH58p_01945	COG0489	protein tyrosine kinase activity
TSH58p_01975	COG1216	Glycosyl transferase, family 2
TSH58p_02045	COG0640	Transcriptional regulator
TSH58p_02050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TSH58p_02075	COG4566	intracellular signal transduction
TSH58p_02090	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_02110	COG0517	IMP dehydrogenase activity
TSH58p_02110	COG1994	Peptidase M50
TSH58p_02135	COG0583	DNA-binding transcription factor activity
TSH58p_02140	COG2271	Major facilitator Superfamily
TSH58p_02145	COG1802	Transcriptional regulator
TSH58p_02150	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_02160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_02165	COG2354	Protein conserved in bacteria
TSH58p_02195	COG1418	mRNA catabolic process
TSH58p_02200	COG1131	(ABC) transporter
TSH58p_02205	COG0842	Transport permease protein
TSH58p_02210	COG3791	Glutathione-dependent formaldehyde-activating
TSH58p_02215	COG0154	amidase activity
TSH58p_02220	COG0154	amidase activity
TSH58p_02225	COG1335	isochorismatase
TSH58p_02230	COG0747	negative chemotaxis
TSH58p_02250	COG4608	Belongs to the ABC transporter superfamily
TSH58p_02255	COG1335	isochorismatase
TSH58p_02260	COG3180	Ammonia monooxygenase
TSH58p_02265	COG1802	Transcriptional regulator
TSH58p_02275	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TSH58p_02280	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TSH58p_02285	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TSH58p_02290	COG2205	protein histidine kinase activity
TSH58p_02300	COG0861	Integral membrane protein TerC family
TSH58p_02315	COG2353	YceI-like domain
TSH58p_02325	COG1196	nuclear chromosome segregation
TSH58p_02335	COG4566	intracellular signal transduction
TSH58p_02340	COG4566	intracellular signal transduction
TSH58p_02345	COG4191	Histidine kinase
TSH58p_02355	COG1538	Outer membrane efflux protein
TSH58p_02360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSH58p_02365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSH58p_02385	COG0339	signal peptide processing
TSH58p_02390	COG4175	Glycine betaine
TSH58p_02395	COG4176	ABC-type proline glycine betaine transport system permease component
TSH58p_02400	COG2113	Glycine betaine
TSH58p_02420	COG1764	response to oxidative stress
TSH58p_02425	COG1846	Transcriptional regulator
TSH58p_02445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_02450	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TSH58p_02470	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TSH58p_02520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TSH58p_02525	COG0392	lysyltransferase activity
TSH58p_02540	COG5001	Diguanylate cyclase
TSH58p_02550	COG0328	RNA-DNA hybrid ribonuclease activity
TSH58p_02550	COG0406	alpha-ribazole phosphatase activity
TSH58p_02555	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TSH58p_02570	COG0477	Major facilitator Superfamily
TSH58p_02575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TSH58p_02580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TSH58p_02585	COG1845	cytochrome c oxidase, subunit III
TSH58p_02590	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TSH58p_02605	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TSH58p_02620	COG3005	denitrification pathway
TSH58p_02645	COG4459	periplasmic nitrate reductase
TSH58p_02660	COG0670	Belongs to the BI1 family
TSH58p_02685	COG2204	response regulator
TSH58p_02690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_02700	COG1850	ribulose-bisphosphate carboxylase activity
TSH58p_02710	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_02715	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_02730	COG3246	L-lysine catabolic process to acetate
TSH58p_02735	COG0028	Belongs to the TPP enzyme family
TSH58p_02760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_02775	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_02780	COG0583	DNA-binding transcription factor activity
TSH58p_02795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TSH58p_02810	COG0438	transferase activity, transferring glycosyl groups
TSH58p_02830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_02850	COG0438	transferase activity, transferring glycosyl groups
TSH58p_02855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_02860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_02865	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TSH58p_02880	COG2197	response regulator
TSH58p_02885	COG2197	response regulator
TSH58p_02895	COG3387	PFAM Glycoside hydrolase 15-related
TSH58p_02925	COG2226	methyltransferase
TSH58p_02940	COG0784	Response regulator, receiver
TSH58p_02940	COG5002	protein histidine kinase activity
TSH58p_02945	COG0154	amidase activity
TSH58p_02955	COG2351	hydroxyisourate hydrolase activity
TSH58p_02965	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_02970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TSH58p_02975	COG3842	ATPase activity
TSH58p_03015	COG0402	S-adenosylhomocysteine deaminase activity
TSH58p_03020	COG1116	anion transmembrane transporter activity
TSH58p_03025	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_03050	COG0243	molybdopterin cofactor binding
TSH58p_03070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TSH58p_03080	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TSH58p_03120	COG1192	Involved in chromosome partitioning
TSH58p_03130	COG1653	transport
TSH58p_03145	COG3842	ATPase activity
TSH58p_03165	COG0840	transmembrane signaling receptor activity
TSH58p_03165	COG0840	transmembrane signaling receptor activity
TSH58p_03180	COG0411	ABC transporter
TSH58p_03190	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_03205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_03210	COG1473	amidohydrolase
TSH58p_03255	COG1971	Probably functions as a manganese efflux pump
TSH58p_03260	COG3290	protein histidine kinase activity
TSH58p_03260	COG0840	transmembrane signaling receptor activity
TSH58p_03285	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_03290	COG0366	Alpha amylase catalytic
TSH58p_03295	COG2388	GCN5-related N-acetyl-transferase
TSH58p_03310	COG1139	Iron-sulfur cluster binding protein
TSH58p_03315	COG0247	lactate metabolic process
TSH58p_03320	COG0277	FAD linked oxidase domain protein
TSH58p_03325	COG1620	l-lactate permease
TSH58p_03330	COG2186	Transcriptional regulator
TSH58p_03340	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TSH58p_03345	COG0542	response to heat
TSH58p_03350	COG1414	Transcriptional regulator
TSH58p_03355	COG3734	2-keto-3-deoxy-galactonokinase
TSH58p_03360	COG0800	Aldolase
TSH58p_03385	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_03410	COG2205	protein histidine kinase activity
TSH58p_03410	COG0784	Response regulator, receiver
TSH58p_03410	COG5002	protein histidine kinase activity
TSH58p_03590	COG0741	lytic transglycosylase activity
TSH58p_03645	COG2204	response regulator
TSH58p_03715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TSH58p_03720	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TSH58p_03735	COG3547	Transposase (IS116 IS110 IS902 family)
TSH58p_03765	COG4651	solute:proton antiporter activity
TSH58p_03765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TSH58p_03780	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TSH58p_03795	COG1648	precorrin-2 dehydrogenase activity
TSH58p_03795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TSH58p_03800	COG0175	sulfate reduction
TSH58p_03805	COG0175	sulfate reduction
TSH58p_03815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSH58p_03815	COG1116	anion transmembrane transporter activity
TSH58p_03825	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TSH58p_03845	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_03850	COG0789	Transcriptional regulator
TSH58p_03865	COG2814	Major facilitator Superfamily
TSH58p_03870	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
TSH58p_03900	COG3706	GGDEF domain
TSH58p_03900	COG0745	RESPONSE REGULATOR receiver
TSH58p_03905	COG0840	transmembrane signaling receptor activity
TSH58p_03935	COG2197	response regulator
TSH58p_03945	COG2197	response regulator
TSH58p_03965	COG1160	GTP binding
TSH58p_03970	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_03975	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TSH58p_03990	COG0024	Methionine aminopeptidase
TSH58p_04005	COG1127	ABC transporter
TSH58p_04010	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TSH58p_04015	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TSH58p_04020	COG0305	Participates in initiation and elongation during chromosome replication
TSH58p_04025	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TSH58p_04030	COG0359	binds to the 23S rRNA
TSH58p_04040	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TSH58p_04045	COG0360	Binds together with S18 to 16S ribosomal RNA
TSH58p_04050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TSH58p_04065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TSH58p_04070	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TSH58p_04080	COG0741	lytic transglycosylase activity
TSH58p_04085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSH58p_04090	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TSH58p_04095	COG2813	Specifically methylates the guanine in position
TSH58p_04100	COG0113	porphobilinogen synthase activity
TSH58p_04105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TSH58p_04110	COG1597	lipid kinase activity
TSH58p_04115	COG1024	Enoyl-CoA hydratase
TSH58p_04120	COG1846	Transcriptional regulator
TSH58p_04140	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_04155	COG0686	Belongs to the AlaDH PNT family
TSH58p_04165	COG0737	Belongs to the 5'-nucleotidase family
TSH58p_04170	COG0512	Glutamine amidotransferase of anthranilate synthase
TSH58p_04175	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TSH58p_04180	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TSH58p_04180	COG3608	succinylglutamate desuccinylase aspartoacylase
TSH58p_04250	COG0123	including yeast histone deacetylase and acetoin utilization protein
TSH58p_04295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TSH58p_04300	COG0626	cystathionine gamma-synthase activity
TSH58p_04305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_04310	COG4597	amino acid ABC transporter
TSH58p_04315	COG0765	amino acid transport
TSH58p_04320	COG1126	abc transporter atp-binding protein
TSH58p_04325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TSH58p_04345	COG2897	thiosulfate sulfurtransferase activity
TSH58p_04360	COG0494	nUDIX hydrolase
TSH58p_04365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSH58p_04475	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TSH58p_04485	COG1538	Outer membrane efflux protein
TSH58p_04495	COG0525	valine-tRNA ligase activity
TSH58p_04500	COG0840	transmembrane signaling receptor activity
TSH58p_04515	COG1686	Belongs to the peptidase S11 family
TSH58p_04520	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TSH58p_04525	COG0470	DNA polymerase III
TSH58p_04530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSH58p_04535	COG0084	hydrolase, TatD family'
TSH58p_04540	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TSH58p_04540	COG0321	lipoyl(octanoyl) transferase activity
TSH58p_04555	COG0631	protein serine/threonine phosphatase activity
TSH58p_04565	COG2957	Belongs to the agmatine deiminase family
TSH58p_04570	COG1177	transmembrane transport
TSH58p_04575	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_04580	COG3842	ATPase activity
TSH58p_04590	COG0174	glutamine synthetase
TSH58p_04595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_04625	COG0861	Integral membrane protein TerC family
TSH58p_04635	COG4957	zinc ion binding
TSH58p_04645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TSH58p_04670	COG1280	lysine exporter protein (LysE YggA)
TSH58p_04680	COG0314	molybdopterin synthase activity
TSH58p_04685	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TSH58p_04695	COG1763	Mo-molybdopterin cofactor biosynthetic process
TSH58p_04700	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TSH58p_04710	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_04755	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TSH58p_04755	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TSH58p_04765	COG0564	pseudouridine synthase activity
TSH58p_04780	COG2198	Histidine kinase
TSH58p_04780	COG0784	Response regulator, receiver
TSH58p_04780	COG2205	protein histidine kinase activity
TSH58p_04785	COG2197	response regulator
TSH58p_04790	COG2885	chlorophyll binding
TSH58p_04790	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TSH58p_04815	COG0410	ABC transporter
TSH58p_04840	COG1940	carbohydrate kinase activity
TSH58p_04860	COG0463	Glycosyl transferase, family 2
TSH58p_04880	COG0704	Plays a role in the regulation of phosphate uptake
TSH58p_04890	COG1846	Transcriptional regulator
TSH58p_04915	COG1396	sequence-specific DNA binding
TSH58p_04945	COG0640	Transcriptional regulator
TSH58p_04960	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TSH58p_04970	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
TSH58p_04975	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TSH58p_04980	COG0830	nickel cation binding
TSH58p_04985	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
TSH58p_04990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TSH58p_04995	COG0804	urea catabolic process
TSH58p_05000	COG0832	Belongs to the urease beta subunit family
TSH58p_05005	COG0831	urea catabolic process
TSH58p_05010	COG1819	glycosyl
TSH58p_05015	COG0829	nickel cation binding
TSH58p_05020	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TSH58p_05030	COG2197	response regulator
TSH58p_05035	COG2197	response regulator
TSH58p_05040	COG0693	protein deglycase activity
TSH58p_05050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_05055	COG3283	Transcriptional regulator of aromatic amino acids metabolism
TSH58p_05080	COG0574	Belongs to the PEP-utilizing enzyme family
TSH58p_05080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSH58p_05090	COG0469	pyruvate kinase activity
TSH58p_05095	COG1802	Transcriptional regulator
TSH58p_05100	COG0352	thiamine-phosphate diphosphorylase activity
TSH58p_05105	COG3960	tartronate-semialdehyde synthase activity
TSH58p_05110	COG3622	Belongs to the hyi family
TSH58p_05115	COG2084	Dehydrogenase
TSH58p_05135	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TSH58p_05155	COG0045	succinate-CoA ligase (ADP-forming) activity
TSH58p_05160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_05180	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TSH58p_05185	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TSH58p_05190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TSH58p_05195	COG0517	IMP dehydrogenase activity
TSH58p_05200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TSH58p_05210	COG0123	including yeast histone deacetylase and acetoin utilization protein
TSH58p_05225	COG0656	L-ascorbic acid biosynthetic process
TSH58p_05235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TSH58p_05235	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TSH58p_05240	COG0371	Dehydrogenase
TSH58p_05245	COG1494	fructose-1,6-bisphosphatase
TSH58p_05255	COG0436	Aminotransferase
TSH58p_05260	COG2814	Major facilitator Superfamily
TSH58p_05275	COG3243	poly(R)-hydroxyalkanoic acid synthase
TSH58p_05280	COG2885	chlorophyll binding
TSH58p_05280	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TSH58p_05285	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TSH58p_05290	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TSH58p_05295	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TSH58p_05300	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TSH58p_05310	COG1024	Enoyl-CoA hydratase
TSH58p_05315	COG1832	CoA-binding protein
TSH58p_05350	COG2205	protein histidine kinase activity
TSH58p_05380	COG0840	transmembrane signaling receptor activity
TSH58p_05385	COG0745	RESPONSE REGULATOR receiver
TSH58p_05415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_05435	COG0436	Aminotransferase
TSH58p_05450	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TSH58p_05465	COG0728	peptidoglycan biosynthetic process
TSH58p_05470	COG0596	Alpha beta hydrolase
TSH58p_05500	COG2986	histidine ammonia-lyase
TSH58p_05525	COG0037	tRNA processing
TSH58p_05535	COG0148	phosphopyruvate hydratase activity
TSH58p_05545	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TSH58p_05550	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
TSH58p_05555	COG0535	radical SAM domain protein
TSH58p_05560	COG0535	radical SAM domain protein
TSH58p_05595	COG0149	triose-phosphate isomerase activity
TSH58p_05605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TSH58p_05650	COG0315	cyclic pyranopterin monophosphate synthase activity
TSH58p_05655	COG0303	'Molybdopterin
TSH58p_05660	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TSH58p_05665	COG0658	competence protein
TSH58p_05665	COG2333	competence protein COMEC
TSH58p_05670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TSH58p_05675	COG0372	Belongs to the citrate synthase family
TSH58p_05690	COG0583	DNA-binding transcription factor activity
TSH58p_05705	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TSH58p_05710	COG3494	Protein of unknown function (DUF1009)
TSH58p_05715	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TSH58p_05735	COG0750	zinc metalloprotease
TSH58p_05740	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TSH58p_05745	COG0575	Belongs to the CDS family
TSH58p_05750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TSH58p_05755	COG0233	cytoplasmic translational termination
TSH58p_05760	COG0528	UMP kinase activity
TSH58p_05765	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TSH58p_05770	COG0052	Belongs to the universal ribosomal protein uS2 family
TSH58p_05775	COG0587	DNA-directed DNA polymerase activity
TSH58p_05805	COG0442	prolyl-tRNA aminoacylation
TSH58p_05820	COG0519	Catalyzes the synthesis of GMP from XMP
TSH58p_05850	COG1007	ATP synthesis coupled electron transport
TSH58p_05865	COG0713	ATP synthesis coupled electron transport
TSH58p_05875	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSH58p_05880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TSH58p_05885	COG1034	ATP synthesis coupled electron transport
TSH58p_05900	COG0649	NAD binding
TSH58p_05910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSH58p_05915	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSH58p_05965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TSH58p_05965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TSH58p_05990	COG0443	Heat shock 70 kDa protein
TSH58p_05995	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_05995	COG2030	dehydratase
TSH58p_06015	COG0670	Belongs to the BI1 family
TSH58p_06030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSH58p_06035	COG0352	thiamine-phosphate diphosphorylase activity
TSH58p_06035	COG0351	phosphomethylpyrimidine kinase
TSH58p_06040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TSH58p_06045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TSH58p_06055	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TSH58p_06060	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TSH58p_06075	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TSH58p_06080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TSH58p_06085	COG3706	GGDEF domain
TSH58p_06085	COG0745	RESPONSE REGULATOR receiver
TSH58p_06130	COG1129	ABC transporter
TSH58p_06135	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TSH58p_06160	COG0546	phosphoglycolate phosphatase activity
TSH58p_06165	COG3135	benzoate transporter
TSH58p_06170	COG1802	Transcriptional regulator
TSH58p_06175	COG0564	pseudouridine synthase activity
TSH58p_06180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TSH58p_06195	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TSH58p_06210	COG1238	metal cluster binding
TSH58p_06215	COG0203	ribosomal protein L17
TSH58p_06230	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TSH58p_06235	COG0469	pyruvate kinase activity
TSH58p_06240	COG3852	Histidine kinase
TSH58p_06245	COG1238	metal cluster binding
TSH58p_06250	COG2832	Protein of unknown function (DUF454)
TSH58p_06260	COG0521	Mo-molybdopterin cofactor biosynthetic process
TSH58p_06275	COG0546	phosphoglycolate phosphatase activity
TSH58p_06290	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_06295	COG2084	Dehydrogenase
TSH58p_06310	COG1733	regulation of RNA biosynthetic process
TSH58p_06325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TSH58p_06330	COG2261	transglycosylase associated protein
TSH58p_06335	COG0784	Response regulator, receiver
TSH58p_06345	COG2135	peptidase activity
TSH58p_06355	COG2203	Gaf domain
TSH58p_06355	COG2199	diguanylate cyclase activity
TSH58p_06355	COG2200	EAL domain
TSH58p_06365	COG0366	Alpha amylase catalytic
TSH58p_06370	COG2326	polyphosphate kinase activity
TSH58p_06380	COG0038	chloride channel
TSH58p_06395	COG0411	ABC transporter
TSH58p_06415	COG0697	spore germination
TSH58p_06430	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TSH58p_06435	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TSH58p_06440	COG0295	cytidine deaminase activity
TSH58p_06475	COG0840	transmembrane signaling receptor activity
TSH58p_06480	COG0768	penicillin binding
TSH58p_06500	COG2862	Uncharacterized protein family, UPF0114
TSH58p_06505	COG0704	Plays a role in the regulation of phosphate uptake
TSH58p_06520	COG0028	Belongs to the TPP enzyme family
TSH58p_06525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSH58p_06530	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TSH58p_06555	COG0330	HflC and HflK could
TSH58p_06560	COG0330	HflC and HflK could
TSH58p_06565	COG0489	protein tyrosine kinase activity
TSH58p_06575	COG0410	ABC transporter
TSH58p_06580	COG4120	Belongs to the binding-protein-dependent transport system permease family
TSH58p_06605	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TSH58p_06620	COG3070	regulator of competence-specific genes
TSH58p_06630	COG0242	peptide deformylase activity
TSH58p_06635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TSH58p_06640	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TSH58p_06650	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TSH58p_06655	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TSH58p_06660	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TSH58p_06765	COG0840	transmembrane signaling receptor activity
TSH58p_06770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TSH58p_06775	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TSH58p_06780	COG0343	queuine tRNA-ribosyltransferase activity
TSH58p_06785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TSH58p_06790	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TSH58p_06810	COG0840	transmembrane signaling receptor activity
TSH58p_06820	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_06880	COG0288	reversible hydration of carbon dioxide
TSH58p_06910	COG0205	6-phosphofructokinase activity
TSH58p_06925	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TSH58p_06930	COG5001	Diguanylate cyclase
TSH58p_06950	COG0114	fumarate hydratase activity
TSH58p_06965	COG0456	acetyltransferase
TSH58p_06975	COG0438	transferase activity, transferring glycosyl groups
TSH58p_07000	COG1454	alcohol dehydrogenase
TSH58p_07020	COG2951	lytic endotransglycosylase activity
TSH58p_07030	COG0432	Pfam Uncharacterised protein family UPF0047
TSH58p_07055	COG0745	RESPONSE REGULATOR receiver
TSH58p_07065	COG5002	protein histidine kinase activity
TSH58p_07070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TSH58p_07070	COG2010	Cytochrome c
TSH58p_07075	COG2080	2 iron, 2 sulfur cluster binding
TSH58p_07080	COG2010	Cytochrome c
TSH58p_07080	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TSH58p_07090	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TSH58p_07100	COG4221	oxidoreductase activity
TSH58p_07125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_07295	COG0456	acetyltransferase
TSH58p_07360	COG0482	sulfurtransferase activity
TSH58p_07365	COG0633	Ferredoxin
TSH58p_07370	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TSH58p_07385	COG1045	serine acetyltransferase
TSH58p_07390	COG2945	thiolester hydrolase activity
TSH58p_07395	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TSH58p_07415	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TSH58p_07420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TSH58p_07425	COG1192	Involved in chromosome partitioning
TSH58p_07430	COG0009	L-threonylcarbamoyladenylate synthase
TSH58p_07445	COG0277	FAD linked oxidase domain protein
TSH58p_07460	COG1960	acyl-CoA dehydrogenase activity
TSH58p_07480	COG0247	lactate metabolic process
TSH58p_07485	COG0277	FAD linked oxidase domain protein
TSH58p_07490	COG0277	FAD linked oxidase domain protein
TSH58p_07500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TSH58p_07510	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
TSH58p_07515	COG0842	Transport permease protein
TSH58p_07525	COG1131	(ABC) transporter
TSH58p_07535	COG1309	transcriptional regulator
TSH58p_07555	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TSH58p_07570	COG5554	nitrogen fixation
TSH58p_07595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TSH58p_07610	COG0121	glutamine amidotransferase
TSH58p_07665	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TSH58p_07670	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TSH58p_07685	COG5420	small protein containing a coiled-coil domain
TSH58p_07745	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TSH58p_07770	COG2205	protein histidine kinase activity
TSH58p_07770	COG5002	protein histidine kinase activity
TSH58p_07770	COG0784	Response regulator, receiver
TSH58p_07780	COG1278	Cold shock
TSH58p_07785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TSH58p_07790	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TSH58p_07800	COG0840	transmembrane signaling receptor activity
TSH58p_07815	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TSH58p_07830	COG2154	pterin-4-alpha-carbinolamine dehydratase
TSH58p_07840	COG1104	cysteine desulfurase activity
TSH58p_07850	COG4948	Mandelate Racemase Muconate Lactonizing
TSH58p_07860	COG0840	transmembrane signaling receptor activity
TSH58p_07875	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TSH58p_07880	COG2894	cell division
TSH58p_07885	COG0850	regulation of cytokinetic process
TSH58p_07890	COG1702	phosphate starvation-inducible protein PhoH
TSH58p_07895	COG0840	transmembrane signaling receptor activity
TSH58p_07905	COG1999	signal sequence binding
TSH58p_07915	COG0356	it plays a direct role in the translocation of protons across the membrane
TSH58p_07920	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TSH58p_07925	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TSH58p_07935	COG3384	dioxygenase
TSH58p_07945	COG0235	Class ii aldolase
TSH58p_07970	COG0437	4 iron, 4 sulfur cluster binding
TSH58p_07975	COG0243	molybdopterin cofactor binding
TSH58p_07975	COG3383	formate dehydrogenase (NAD+) activity
TSH58p_08000	COG0746	molybdenum cofactor guanylyltransferase activity
TSH58p_08005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TSH58p_08020	COG1686	Belongs to the peptidase S11 family
TSH58p_08045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TSH58p_08060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_08070	COG0590	tRNA wobble adenosine to inosine editing
TSH58p_08095	COG2703	oxygen carrier activity
TSH58p_08100	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TSH58p_08135	COG2030	dehydratase
TSH58p_08140	COG0196	riboflavin kinase activity
TSH58p_08150	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TSH58p_08155	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TSH58p_08160	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TSH58p_08170	COG0612	Peptidase, M16
TSH58p_08175	COG0612	Peptidase, M16
TSH58p_08185	COG0166	Belongs to the GPI family
TSH58p_08205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TSH58p_08215	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSH58p_08215	COG0596	Alpha beta hydrolase
TSH58p_08220	COG0022	dehydrogenase e1 component
TSH58p_08225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TSH58p_08230	COG3199	ATP-NAD kinase
TSH58p_08235	COG3284	Transcriptional regulator
TSH58p_08240	COG0604	alcohol dehydrogenase
TSH58p_08245	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_08270	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_08280	COG1309	transcriptional regulator
TSH58p_08295	COG1609	Transcriptional regulator
TSH58p_08300	COG3608	succinylglutamate desuccinylase aspartoacylase
TSH58p_08305	COG0251	oxidation-reduction process
TSH58p_08320	COG4597	amino acid ABC transporter
TSH58p_08325	COG0765	amino acid transport
TSH58p_08350	COG1116	anion transmembrane transporter activity
TSH58p_08360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSH58p_08370	COG0628	permease
TSH58p_08380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSH58p_08395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TSH58p_08465	COG0667	Aldo Keto reductase
TSH58p_08475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_08485	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TSH58p_08490	COG1749	Flagellar hook protein flgE
TSH58p_08515	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TSH58p_08565	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TSH58p_08580	COG0742	ribosomal rna small subunit methyltransferase
TSH58p_08585	COG1187	pseudouridine synthase activity
TSH58p_08590	COG3360	Dodecin
TSH58p_08595	COG0590	tRNA wobble adenosine to inosine editing
TSH58p_08610	COG1570	exodeoxyribonuclease VII activity
TSH58p_08615	COG0418	dihydroorotase activity
TSH58p_08620	COG0124	histidyl-tRNA synthetase
TSH58p_08665	COG1546	Belongs to the CinA family
TSH58p_08665	COG1058	Belongs to the CinA family
TSH58p_08670	COG1489	DNA binding
TSH58p_08675	COG0024	Methionine aminopeptidase
TSH58p_08680	COG2003	Belongs to the UPF0758 family
TSH58p_08695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TSH58p_08710	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TSH58p_08715	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TSH58p_08725	COG2258	MOSC domain
TSH58p_08735	COG0583	DNA-binding transcription factor activity
TSH58p_08740	COG0047	phosphoribosylformylglycinamidine synthase activity
TSH58p_08745	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TSH58p_08755	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
TSH58p_08765	COG2962	Rard protein
TSH58p_08775	COG1902	pentaerythritol trinitrate reductase activity
TSH58p_08790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TSH58p_08810	COG3279	Response regulator of the LytR AlgR family
TSH58p_08820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TSH58p_08830	COG5002	protein histidine kinase activity
TSH58p_08840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TSH58p_08850	COG2205	protein histidine kinase activity
TSH58p_08850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_08860	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
TSH58p_08885	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_08905	COG1238	metal cluster binding
TSH58p_08910	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_08915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TSH58p_08925	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TSH58p_08945	COG1674	ftsk spoiiie
TSH58p_08970	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TSH58p_08975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TSH58p_08985	COG1522	sequence-specific DNA binding
TSH58p_08990	COG3660	Nucleoside-diphosphate-sugar epimerase
TSH58p_09005	COG0492	ferredoxin-NADP+ reductase activity
TSH58p_09015	COG0783	Belongs to the Dps family
TSH58p_09025	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TSH58p_09030	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TSH58p_09085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_09090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_09095	COG1116	anion transmembrane transporter activity
TSH58p_09105	COG2081	HI0933 family
TSH58p_09115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSH58p_09120	COG2814	Major facilitator Superfamily
TSH58p_09125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSH58p_09175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TSH58p_09180	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TSH58p_09185	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TSH58p_09195	COG0167	dihydroorotate dehydrogenase activity
TSH58p_09310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TSH58p_09345	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TSH58p_09355	COG2084	Dehydrogenase
TSH58p_09370	COG2972	Histidine kinase
TSH58p_09370	COG0840	transmembrane signaling receptor activity
TSH58p_09375	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TSH58p_09385	COG0840	transmembrane signaling receptor activity
TSH58p_09395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TSH58p_09405	COG2076	Multidrug Resistance protein
TSH58p_09410	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TSH58p_09425	COG0039	L-malate dehydrogenase activity
TSH58p_09430	COG0045	succinate-CoA ligase (ADP-forming) activity
TSH58p_09445	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSH58p_09450	COG2205	protein histidine kinase activity
TSH58p_09455	COG3706	GGDEF domain
TSH58p_09460	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TSH58p_09475	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
TSH58p_09525	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TSH58p_09530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSH58p_09535	COG0552	protein localization to endoplasmic reticulum
TSH58p_09540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TSH58p_09550	COG2917	probably involved in intracellular septation
TSH58p_09565	COG0745	RESPONSE REGULATOR receiver
TSH58p_09570	COG2176	DNA-directed DNA polymerase activity
TSH58p_09570	COG5002	protein histidine kinase activity
TSH58p_09580	COG5002	protein histidine kinase activity
TSH58p_09595	COG0643	Histidine kinase
TSH58p_09595	COG2198	Histidine kinase
TSH58p_09600	COG0835	chemotaxis
TSH58p_09610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TSH58p_09615	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TSH58p_09620	COG2201	protein-glutamate methylesterase activity
TSH58p_09625	COG0840	transmembrane signaling receptor activity
TSH58p_09630	COG1366	Belongs to the anti-sigma-factor antagonist family
TSH58p_09640	COG0745	RESPONSE REGULATOR receiver
TSH58p_09640	COG3706	GGDEF domain
TSH58p_09645	COG0745	RESPONSE REGULATOR receiver
TSH58p_09665	COG0745	RESPONSE REGULATOR receiver
TSH58p_09680	COG4191	Histidine kinase
TSH58p_09685	COG5002	protein histidine kinase activity
TSH58p_09685	COG2205	protein histidine kinase activity
TSH58p_09685	COG0784	Response regulator, receiver
TSH58p_09705	COG0513	Belongs to the DEAD box helicase family
TSH58p_09720	COG0625	glutathione transferase activity
TSH58p_09725	COG3842	ATPase activity
TSH58p_09730	COG0395	ABC-type sugar transport system, permease component
TSH58p_09750	COG2205	protein histidine kinase activity
TSH58p_09750	COG0784	Response regulator, receiver
TSH58p_09760	COG2814	Major facilitator Superfamily
TSH58p_09765	COG1285	pathogenesis
TSH58p_09800	COG2835	tetraacyldisaccharide 4'-kinase activity
TSH58p_09805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TSH58p_09810	COG3118	belongs to the thioredoxin family
TSH58p_09815	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
TSH58p_09825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSH58p_09830	COG0679	Auxin Efflux Carrier
TSH58p_09840	COG0840	transmembrane signaling receptor activity
TSH58p_09850	COG3437	response regulator, receiver
TSH58p_09850	COG2770	Histidine kinase
TSH58p_09855	COG2902	Dehydrogenase
TSH58p_09860	COG2264	protein methyltransferase activity
TSH58p_09885	COG0138	bifunctional purine biosynthesis protein purh
TSH58p_09895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TSH58p_09895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TSH58p_09910	COG0501	Belongs to the peptidase M48B family
TSH58p_09915	COG5508	conserved small protein
TSH58p_09930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSH58p_09945	COG2350	Protein conserved in bacteria
TSH58p_09950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TSH58p_09965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TSH58p_09970	COG0181	hydroxymethylbilane synthase activity
TSH58p_10000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSH58p_10030	COG2885	chlorophyll binding
TSH58p_10040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TSH58p_10050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_10050	COG4191	Histidine kinase
TSH58p_10055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TSH58p_10075	COG5002	protein histidine kinase activity
TSH58p_10090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_10120	COG2967	ApaG domain
TSH58p_10125	COG0302	gtp cyclohydrolase
TSH58p_10135	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TSH58p_10155	COG0444	Belongs to the ABC transporter superfamily
TSH58p_10165	COG0601	transmembrane transport
TSH58p_10170	COG0747	negative chemotaxis
TSH58p_10230	COG0671	phosphoesterase, PA-phosphatase related
TSH58p_10240	COG3437	response regulator, receiver
TSH58p_10240	COG0784	Response regulator, receiver
TSH58p_10255	COG1983	PspC domain protein
TSH58p_10265	COG1842	Phage shock protein A
TSH58p_10270	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TSH58p_10280	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TSH58p_10295	COG3005	denitrification pathway
TSH58p_10300	COG1858	cytochrome C peroxidase
TSH58p_10305	COG0753	catalase activity
TSH58p_10310	COG0459	protein refolding
TSH58p_10315	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TSH58p_10320	COG5425	PFAM Usg family protein
TSH58p_10325	COG3772	lysozyme
TSH58p_10330	COG0493	'glutamate synthase
TSH58p_10330	COG0543	2 iron, 2 sulfur cluster binding
TSH58p_10335	COG1612	heme a metabolic process
TSH58p_10365	COG4608	Belongs to the ABC transporter superfamily
TSH58p_10370	COG0668	transmembrane transport
TSH58p_10375	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
TSH58p_10380	COG4181	ATPase activity
TSH58p_10395	COG0667	Aldo Keto reductase
TSH58p_10400	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TSH58p_10405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TSH58p_10410	COG0347	Belongs to the P(II) protein family
TSH58p_10435	COG0606	chelatase, subunit chli
TSH58p_10445	COG0747	negative chemotaxis
TSH58p_10455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_10460	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TSH58p_10495	COG2304	oxidoreductase activity
TSH58p_10505	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSH58p_10510	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSH58p_10510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TSH58p_10515	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TSH58p_10525	COG2205	protein histidine kinase activity
TSH58p_10525	COG2202	Pas domain
TSH58p_10530	COG0693	protein deglycase activity
TSH58p_10535	COG2224	Isocitrate lyase
TSH58p_10540	COG1396	sequence-specific DNA binding
TSH58p_10540	COG3800	Transcriptional regulator
TSH58p_10555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TSH58p_10560	COG0784	Response regulator, receiver
TSH58p_10560	COG3437	response regulator, receiver
TSH58p_10565	COG3706	GGDEF domain
TSH58p_10570	COG0484	heat shock protein binding
TSH58p_10575	COG0443	Heat shock 70 kDa protein
TSH58p_10600	COG0745	RESPONSE REGULATOR receiver
TSH58p_10610	COG1420	regulation of RNA biosynthetic process
TSH58p_10615	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TSH58p_10620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TSH58p_10625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TSH58p_10635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TSH58p_10660	COG0792	nuclease activity
TSH58p_10665	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TSH58p_10685	COG1366	Belongs to the anti-sigma-factor antagonist family
TSH58p_10695	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TSH58p_10750	COG0180	Tryptophanyl-tRNA synthetase
TSH58p_10755	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TSH58p_10765	COG3012	SEC-C Motif Domain Protein
TSH58p_10780	COG0110	maltose O-acetyltransferase activity
TSH58p_10785	COG1309	transcriptional regulator
TSH58p_10790	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_10805	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TSH58p_10810	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TSH58p_10815	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TSH58p_10835	COG0406	alpha-ribazole phosphatase activity
TSH58p_10840	COG0438	transferase activity, transferring glycosyl groups
TSH58p_10845	COG3706	GGDEF domain
TSH58p_10860	COG1132	(ABC) transporter
TSH58p_10865	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_10865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TSH58p_10885	COG4172	Belongs to the ABC transporter superfamily
TSH58p_10895	COG0601	transmembrane transport
TSH58p_10900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_10910	COG1234	tRNA 3'-trailer cleavage
TSH58p_10930	COG0745	RESPONSE REGULATOR receiver
TSH58p_11000	COG1475	DNA binding
TSH58p_11005	COG1192	Involved in chromosome partitioning
TSH58p_11010	COG0357	Ribosomal RNA small subunit methyltransferase G
TSH58p_11015	COG0445	tRNA wobble uridine modification
TSH58p_11025	COG3411	Ferredoxin
TSH58p_11035	COG1331	Highly conserved protein containing a thioredoxin domain
TSH58p_11040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TSH58p_11050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TSH58p_11055	COG0237	dephospho-CoA kinase activity
TSH58p_11090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TSH58p_11095	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
TSH58p_11105	COG4395	Tim44
TSH58p_11110	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
TSH58p_11165	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TSH58p_11175	COG2205	protein histidine kinase activity
TSH58p_11195	COG1139	Iron-sulfur cluster binding protein
TSH58p_11200	COG0247	lactate metabolic process
TSH58p_11205	COG0840	transmembrane signaling receptor activity
TSH58p_11220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TSH58p_11225	COG1121	(ABC) transporter
TSH58p_11235	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TSH58p_11240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TSH58p_11250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TSH58p_11265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TSH58p_11270	COG0730	response to heat
TSH58p_11295	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TSH58p_11305	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
TSH58p_11340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSH58p_11345	COG1702	phosphate starvation-inducible protein PhoH
TSH58p_11355	COG1253	flavin adenine dinucleotide binding
TSH58p_11360	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TSH58p_11365	COG1396	sequence-specific DNA binding
TSH58p_11370	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TSH58p_11375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TSH58p_11380	COG2329	Antibiotic biosynthesis monooxygenase
TSH58p_11385	COG0779	Required for maturation of 30S ribosomal subunits
TSH58p_11410	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TSH58p_11420	COG1185	polyribonucleotide nucleotidyltransferase activity
TSH58p_11435	COG2321	neutral zinc metallopeptidase
TSH58p_11445	COG1509	lysine 2,3-aminomutase activity
TSH58p_11450	COG0584	glycerophosphoryl diester phosphodiesterase
TSH58p_11465	COG1592	Rubrerythrin
TSH58p_11490	COG0039	L-malate dehydrogenase activity
TSH58p_11495	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TSH58p_11500	COG4166	transmembrane transport
TSH58p_11510	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TSH58p_11515	COG2226	methyltransferase
TSH58p_11520	COG0457	Tetratricopeptide repeat
TSH58p_11520	COG0859	PFAM glycosyl transferase family 9
TSH58p_11525	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TSH58p_11535	COG1024	Enoyl-CoA hydratase
TSH58p_11540	COG0268	Binds directly to 16S ribosomal RNA
TSH58p_11545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TSH58p_11550	COG3706	GGDEF domain
TSH58p_11555	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TSH58p_11560	COG3842	ATPase activity
TSH58p_11580	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_11585	COG1177	transmembrane transport
TSH58p_11600	COG2132	Multicopper oxidase
TSH58p_11620	COG3278	Belongs to the heme-copper respiratory oxidase family
TSH58p_11650	COG2217	Heavy metal translocating P-type atpase
TSH58p_11660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_11665	COG0280	phosphate acetyltransferase
TSH58p_11665	COG0281	malic enzyme
TSH58p_11670	COG5002	protein histidine kinase activity
TSH58p_11675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TSH58p_11680	COG0573	inorganic phosphate transmembrane transporter activity
TSH58p_11690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TSH58p_11695	COG0704	Plays a role in the regulation of phosphate uptake
TSH58p_11700	COG0745	RESPONSE REGULATOR receiver
TSH58p_11715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TSH58p_11725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TSH58p_11735	COG0756	dUTP diphosphatase activity
TSH58p_11740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TSH58p_11745	COG2204	response regulator
TSH58p_11750	COG1278	Cold shock
TSH58p_11755	COG5002	protein histidine kinase activity
TSH58p_11755	COG2205	protein histidine kinase activity
TSH58p_11755	COG0784	Response regulator, receiver
TSH58p_11760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TSH58p_11765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TSH58p_11765	COG1321	iron dependent repressor
TSH58p_11770	COG1121	(ABC) transporter
TSH58p_11775	COG0803	Belongs to the bacterial solute-binding protein 9 family
TSH58p_11835	COG1253	flavin adenine dinucleotide binding
TSH58p_11850	COG0477	Major facilitator Superfamily
TSH58p_11855	COG0583	DNA-binding transcription factor activity
TSH58p_11875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TSH58p_11880	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TSH58p_11885	COG4783	chaperone-mediated protein folding
TSH58p_11900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TSH58p_11905	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TSH58p_11910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TSH58p_11925	COG3437	response regulator, receiver
TSH58p_11925	COG0784	Response regulator, receiver
TSH58p_11935	COG0583	DNA-binding transcription factor activity
TSH58p_11945	COG0481	GTPase activity
TSH58p_11955	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TSH58p_11960	COG0297	glycogen (starch) synthase activity
TSH58p_11965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TSH58p_11970	COG0004	ammonium transporteR
TSH58p_12000	COG3806	Anti-sigma factor
TSH58p_12005	COG1595	DNA-templated transcription, initiation
TSH58p_12015	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TSH58p_12030	COG0137	argininosuccinate synthase activity
TSH58p_12050	COG3339	Conserved Protein
TSH58p_12055	COG0697	spore germination
TSH58p_12060	COG4235	cytochrome complex assembly
TSH58p_12065	COG3088	subunit of a heme lyase
TSH58p_12070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TSH58p_12075	COG1138	Cytochrome C-type biogenesis protein
TSH58p_12080	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TSH58p_12090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TSH58p_12120	COG2985	domain, Protein
TSH58p_12125	COG2985	domain, Protein
TSH58p_12130	COG4133	protoheme IX ABC transporter activity
TSH58p_12135	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TSH58p_12140	COG1715	Restriction endonuclease
TSH58p_12155	COG1872	DUF167
TSH58p_12160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TSH58p_12165	COG0598	Magnesium transport protein CorA
TSH58p_12175	COG2154	pterin-4-alpha-carbinolamine dehydratase
TSH58p_12185	COG1573	uracil-dna glycosylase
TSH58p_12190	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TSH58p_12195	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TSH58p_12210	COG0583	DNA-binding transcription factor activity
TSH58p_12220	COG1074	ATP-dependent DNA helicase activity
TSH58p_12225	COG2887	Belongs to the helicase family. UvrD subfamily
TSH58p_12230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TSH58p_12240	COG0802	atpase or kinase
TSH58p_12260	COG0745	RESPONSE REGULATOR receiver
TSH58p_12270	COG1252	NADH dehydrogenase
TSH58p_12275	COG2205	protein histidine kinase activity
TSH58p_12280	COG0784	Response regulator, receiver
TSH58p_12280	COG2205	protein histidine kinase activity
TSH58p_12280	COG5002	protein histidine kinase activity
TSH58p_12285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_12290	COG0133	tryptophan synthase activity
TSH58p_12300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TSH58p_12305	COG0285	dihydrofolate synthase activity
TSH58p_12335	COG2205	protein histidine kinase activity
TSH58p_12340	COG0302	gtp cyclohydrolase
TSH58p_12370	COG1278	Cold shock
TSH58p_12375	COG0033	Phosphoglucomutase
TSH58p_12380	COG0412	Dienelactone hydrolase
TSH58p_12385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TSH58p_12390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TSH58p_12420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_12455	COG0514	ATP-dependent DNA helicase (RecQ)
TSH58p_12460	COG0494	nUDIX hydrolase
TSH58p_12470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TSH58p_12475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TSH58p_12480	COG0653	protein targeting
TSH58p_12485	COG1970	mechanosensitive ion channel activity
TSH58p_12490	COG0513	Belongs to the DEAD box helicase family
TSH58p_12495	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TSH58p_12520	COG1987	bacterial-type flagellum assembly
TSH58p_12525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TSH58p_12530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TSH58p_12535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TSH58p_12540	COG1971	Probably functions as a manganese efflux pump
TSH58p_12555	COG3162	membrane
TSH58p_12590	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_12640	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TSH58p_12665	COG0071	Belongs to the small heat shock protein (HSP20) family
TSH58p_12675	COG0463	Glycosyl transferase, family 2
TSH58p_12685	COG2205	protein histidine kinase activity
TSH58p_12685	COG0784	Response regulator, receiver
TSH58p_12685	COG5002	protein histidine kinase activity
TSH58p_12690	COG3706	GGDEF domain
TSH58p_12690	COG0745	RESPONSE REGULATOR receiver
TSH58p_12705	COG1741	Belongs to the pirin family
TSH58p_12730	COG0405	Gamma-glutamyltransferase
TSH58p_12745	COG0539	negative regulation of cytoplasmic translation
TSH58p_12755	COG0776	regulation of translation
TSH58p_12765	COG2423	ornithine cyclodeaminase activity
TSH58p_12785	COG0135	phosphoribosylanthranilate isomerase activity
TSH58p_12790	COG3706	GGDEF domain
TSH58p_12790	COG0745	RESPONSE REGULATOR receiver
TSH58p_12795	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TSH58p_12800	COG1178	ABC-type Fe3 transport system permease component
TSH58p_12805	COG1741	Belongs to the pirin family
TSH58p_12810	COG1840	ABC-type Fe3 transport system, periplasmic component
TSH58p_12840	COG0271	Belongs to the BolA IbaG family
TSH58p_12855	COG0517	IMP dehydrogenase activity
TSH58p_12860	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TSH58p_12880	COG4974	Belongs to the 'phage' integrase family
TSH58p_12885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TSH58p_12895	COG0825	malonyl-CoA metabolic process
TSH58p_12910	COG0598	Magnesium transport protein CorA
TSH58p_12920	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TSH58p_12935	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TSH58p_12940	COG0706	membrane insertase activity
TSH58p_12945	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TSH58p_12955	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TSH58p_12995	COG0438	transferase activity, transferring glycosyl groups
TSH58p_13010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_13020	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TSH58p_13030	COG3206	protein involved in exopolysaccharide biosynthesis
TSH58p_13030	COG0489	protein tyrosine kinase activity
TSH58p_13050	COG0697	spore germination
TSH58p_13055	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TSH58p_13065	COG1131	(ABC) transporter
TSH58p_13075	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TSH58p_13090	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TSH58p_13105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_13145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TSH58p_13150	COG0228	four-way junction DNA binding
TSH58p_13155	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TSH58p_13165	COG0335	large ribosomal subunit rRNA binding
TSH58p_13180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TSH58p_13185	COG2378	regulation of single-species biofilm formation
TSH58p_13200	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_13205	COG0101	tRNA pseudouridine synthase activity
TSH58p_13210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TSH58p_13215	COG0242	peptide deformylase activity
TSH58p_13225	COG1278	Cold shock
TSH58p_13230	COG1322	Protein conserved in bacteria
TSH58p_13245	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_13260	COG0156	8-amino-7-oxononanoate synthase activity
TSH58p_13270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TSH58p_13285	COG5001	Diguanylate cyclase
TSH58p_13310	COG0583	DNA-binding transcription factor activity
TSH58p_13325	COG1024	Enoyl-CoA hydratase
TSH58p_13335	COG0601	transmembrane transport
TSH58p_13340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_13350	COG0625	glutathione transferase activity
TSH58p_13355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TSH58p_13390	COG0587	DNA-directed DNA polymerase activity
TSH58p_13395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TSH58p_13420	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TSH58p_13425	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TSH58p_13445	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TSH58p_13455	COG4172	Belongs to the ABC transporter superfamily
TSH58p_13460	COG4239	(ABC) transporter, permease
TSH58p_13465	COG4174	ABC transporter (Permease)
TSH58p_13470	COG4166	transmembrane transport
TSH58p_13480	COG4166	transmembrane transport
TSH58p_13485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TSH58p_13520	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TSH58p_13525	COG3474	cytochrome
TSH58p_13540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TSH58p_13550	COG0126	phosphoglycerate kinase activity
TSH58p_13575	COG4106	trans-aconitate 2-methyltransferase activity
TSH58p_13585	COG4191	Histidine kinase
TSH58p_13605	COG0596	Alpha beta hydrolase
TSH58p_13615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TSH58p_13620	COG4974	Belongs to the 'phage' integrase family
TSH58p_13630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TSH58p_13650	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TSH58p_13660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TSH58p_13680	COG1051	belongs to the nudix hydrolase family
TSH58p_13690	COG0793	Belongs to the peptidase S41A family
TSH58p_13700	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TSH58p_13705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TSH58p_13710	COG0799	negative regulation of ribosome biogenesis
TSH58p_13725	COG2010	Cytochrome c
TSH58p_13725	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TSH58p_13735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TSH58p_13745	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TSH58p_13750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TSH58p_13755	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TSH58p_13795	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TSH58p_13815	COG2972	Histidine kinase
TSH58p_13815	COG0840	transmembrane signaling receptor activity
TSH58p_13820	COG0463	Glycosyl transferase, family 2
TSH58p_13830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TSH58p_13845	COG0723	plastoquinol--plastocyanin reductase activity
TSH58p_13860	COG1131	(ABC) transporter
TSH58p_13910	COG1116	anion transmembrane transporter activity
TSH58p_13950	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
TSH58p_13965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TSH58p_13970	COG0784	Response regulator, receiver
TSH58p_13970	COG2205	protein histidine kinase activity
TSH58p_13980	COG0745	RESPONSE REGULATOR receiver
TSH58p_13985	COG2766	serine protein kinase
TSH58p_13990	COG2718	Belongs to the UPF0229 family
TSH58p_13995	COG2719	SpoVR family
TSH58p_14010	COG1643	Atp-dependent helicase
TSH58p_14015	COG1116	anion transmembrane transporter activity
TSH58p_14035	COG0745	RESPONSE REGULATOR receiver
TSH58p_14060	COG0330	HflC and HflK could
TSH58p_14065	COG0628	permease
TSH58p_14080	COG3180	Ammonia monooxygenase
TSH58p_14085	COG2988	succinylglutamate desuccinylase activity
TSH58p_14125	COG2205	protein histidine kinase activity
TSH58p_14125	COG2202	Pas domain
TSH58p_14135	COG2205	protein histidine kinase activity
TSH58p_14145	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TSH58p_14185	COG2197	response regulator
TSH58p_14190	COG2197	response regulator
TSH58p_14195	COG0210	DNA helicase
TSH58p_14210	COG2264	protein methyltransferase activity
TSH58p_14220	COG0006	proline dipeptidase activity
TSH58p_14220	COG0006	proline dipeptidase activity
TSH58p_14225	COG0745	RESPONSE REGULATOR receiver
TSH58p_14240	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TSH58p_14245	COG0497	DNA recombination
TSH58p_14270	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TSH58p_14285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TSH58p_14290	COG0849	cell division
TSH58p_14295	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TSH58p_14300	COG1181	Belongs to the D-alanine--D-alanine ligase family
TSH58p_14310	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TSH58p_14315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TSH58p_14325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TSH58p_14340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TSH58p_14350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TSH58p_14370	COG2001	Belongs to the MraZ family
TSH58p_14385	COG0697	spore germination
TSH58p_14395	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TSH58p_14410	COG0277	FAD linked oxidase domain protein
TSH58p_14415	COG2084	Dehydrogenase
TSH58p_14430	COG0784	Response regulator, receiver
TSH58p_14430	COG4191	Histidine kinase
TSH58p_14455	COG0142	geranyltranstransferase activity
TSH58p_14465	COG2890	protein-(glutamine-N5) methyltransferase activity
TSH58p_14485	COG0752	glycyl-tRNA synthetase alpha subunit
TSH58p_14490	COG0751	glycine-tRNA ligase activity
TSH58p_14495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TSH58p_14500	COG1346	cytolysis
TSH58p_14505	COG1380	Effector of murein hydrolase LrgA
TSH58p_14510	COG1073	alpha beta
TSH58p_14540	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TSH58p_14550	COG2205	protein histidine kinase activity
TSH58p_14580	COG0860	N-Acetylmuramoyl-L-alanine amidase
TSH58p_14580	COG3409	Peptidoglycan-binding domain 1 protein
TSH58p_14585	COG3108	Peptidase M15
TSH58p_14600	COG0840	transmembrane signaling receptor activity
TSH58p_14615	COG1230	cation diffusion facilitator family transporter
TSH58p_14640	COG0511	ligase activity, forming carbon-carbon bonds
TSH58p_14645	COG0439	Biotin carboxylase
TSH58p_14650	COG3719	Belongs to the RNase T2 family
TSH58p_14655	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
TSH58p_14680	COG1280	lysine exporter protein (LysE YggA)
TSH58p_14690	COG1663	tetraacyldisaccharide 4'-kinase activity
TSH58p_14695	COG1519	Transferase
TSH58p_14715	COG1597	lipid kinase activity
TSH58p_14730	COG0312	modulator of DNA gyrase
TSH58p_14745	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TSH58p_14770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TSH58p_14810	COG1530	ribonuclease E activity
TSH58p_14820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TSH58p_14860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSH58p_14880	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TSH58p_14895	COG1309	transcriptional regulator
TSH58p_14900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_14910	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TSH58p_14920	COG0673	inositol 2-dehydrogenase activity
TSH58p_14940	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_14950	COG0411	ABC transporter
TSH58p_14955	COG0410	ABC transporter
TSH58p_14960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_14965	COG0840	transmembrane signaling receptor activity
TSH58p_14975	COG1940	carbohydrate kinase activity
TSH58p_14985	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TSH58p_15000	COG0410	ABC transporter
TSH58p_15070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TSH58p_15105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TSH58p_15110	COG0081	regulation of translation
TSH58p_15115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TSH58p_15120	COG0222	ribosome binding
TSH58p_15125	COG0085	RNA polymerase activity
TSH58p_15130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TSH58p_15145	COG0049	tRNA binding
TSH58p_15160	COG0051	transcription antitermination factor activity, RNA binding
TSH58p_15170	COG0088	Forms part of the polypeptide exit tunnel
TSH58p_15175	COG0089	rRNA binding
TSH58p_15180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TSH58p_15185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TSH58p_15190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TSH58p_15195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TSH58p_15200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TSH58p_15205	COG0255	Belongs to the universal ribosomal protein uL29 family
TSH58p_15210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TSH58p_15220	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TSH58p_15230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TSH58p_15235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TSH58p_15240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TSH58p_15255	COG1841	ribosomal large subunit assembly
TSH58p_15260	COG0200	Binds to the 23S rRNA
TSH58p_15265	COG0201	protein transport
TSH58p_15270	COG0563	adenylate kinase activity
TSH58p_15275	COG2186	Transcriptional regulator
TSH58p_15290	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TSH58p_15305	COG2205	protein histidine kinase activity
TSH58p_15310	COG0071	Belongs to the small heat shock protein (HSP20) family
TSH58p_15320	COG0254	rRNA binding
TSH58p_15325	COG1132	(ABC) transporter
TSH58p_15335	COG0500	methyltransferase
TSH58p_15350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TSH58p_15360	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TSH58p_15390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TSH58p_15395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TSH58p_15405	COG4786	Flagellar basal body rod
TSH58p_15410	COG4786	Flagellar basal body rod
TSH58p_15450	COG1360	Flagellar Motor Protein
TSH58p_15465	COG1338	Plays a role in the flagellum-specific transport system
TSH58p_15480	COG2257	FlhB HrpN YscU SpaS Family
TSH58p_15485	COG1815	bacterial-type flagellum-dependent cell motility
TSH58p_15490	COG1558	bacterial-type flagellum-dependent cell motility
TSH58p_15495	COG1677	Flagellar hook-basal body complex protein FliE
TSH58p_15500	COG1987	bacterial-type flagellum assembly
TSH58p_15505	COG1684	flagellar biosynthetic protein fliR
TSH58p_15510	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TSH58p_15530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TSH58p_15545	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TSH58p_15565	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TSH58p_15595	COG0473	3-isopropylmalate dehydrogenase activity
TSH58p_15615	COG3932	Exopolysaccharide synthesis, ExoD
TSH58p_15625	COG0538	isocitrate dehydrogenase activity
TSH58p_15665	COG0456	acetyltransferase
TSH58p_15670	COG2890	protein-(glutamine-N5) methyltransferase activity
TSH58p_15675	COG1393	Belongs to the ArsC family
TSH58p_15680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TSH58p_15690	COG1403	HNH endonuclease
TSH58p_15700	COG0505	Belongs to the CarA family
TSH58p_15715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TSH58p_15745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TSH58p_15755	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TSH58p_15795	COG0251	oxidation-reduction process
TSH58p_15800	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TSH58p_15810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSH58p_15820	COG2205	protein histidine kinase activity
TSH58p_15825	COG0628	permease
TSH58p_15835	COG0577	efflux transmembrane transporter activity
TSH58p_15835	COG1136	(ABC) transporter
TSH58p_15840	COG0390	transport system, permease component
TSH58p_15850	COG0784	Response regulator, receiver
TSH58p_15850	COG5002	protein histidine kinase activity
TSH58p_15850	COG2198	Histidine kinase
TSH58p_15865	COG0616	signal peptide processing
TSH58p_15875	COG0745	RESPONSE REGULATOR receiver
TSH58p_15885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TSH58p_15895	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TSH58p_15900	COG1295	ribonuclease BN
TSH58p_15905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSH58p_15920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TSH58p_15930	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TSH58p_15935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TSH58p_15940	COG3266	domain, Protein
TSH58p_15940	COG0515	serine threonine protein kinase
TSH58p_15950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TSH58p_15955	COG0564	pseudouridine synthase activity
TSH58p_15985	COG0741	lytic transglycosylase activity
TSH58p_15995	COG5487	UPF0391 membrane protein
TSH58p_16005	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TSH58p_16015	COG0312	modulator of DNA gyrase
TSH58p_16025	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TSH58p_16025	COG1565	acr, cog1565
TSH58p_16030	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TSH58p_16035	COG0109	protoheme IX farnesyltransferase activity
TSH58p_16050	COG1845	cytochrome c oxidase, subunit III
TSH58p_16060	COG3346	SURF1 family
TSH58p_16065	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TSH58p_16070	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TSH58p_16080	COG0612	Peptidase, M16
TSH58p_16085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TSH58p_16095	COG1678	Uncharacterized ACR, COG1678
TSH58p_16105	COG0678	peroxiredoxin activity
TSH58p_16110	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_16120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TSH58p_16130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TSH58p_16150	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TSH58p_16155	COG0509	glycine decarboxylation via glycine cleavage system
TSH58p_16160	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TSH58p_16165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TSH58p_16185	COG0483	inositol monophosphate 1-phosphatase activity
TSH58p_16190	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TSH58p_16195	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TSH58p_16200	COG0604	alcohol dehydrogenase
TSH58p_16205	COG2067	long-chain fatty acid transport protein
TSH58p_16210	COG0730	response to heat
TSH58p_16215	COG0352	thiamine-phosphate diphosphorylase activity
TSH58p_16220	COG1830	Aldolase
TSH58p_16265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TSH58p_16270	COG1692	metallophosphoesterase
TSH58p_16275	COG0217	transcriptional regulatory protein
TSH58p_16280	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TSH58p_16290	COG2255	four-way junction helicase activity
TSH58p_16295	COG0824	Thioesterase
TSH58p_16305	COG0848	biopolymer transport protein
TSH58p_16320	COG2885	chlorophyll binding
TSH58p_16335	COG1086	Polysaccharide biosynthesis protein
TSH58p_16345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TSH58p_16350	COG0438	transferase activity, transferring glycosyl groups
TSH58p_16365	COG0367	asparagine synthase
TSH58p_16370	COG0697	spore germination
TSH58p_16380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TSH58p_16390	COG1765	OsmC-like protein
TSH58p_16395	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_16400	COG2076	Multidrug Resistance protein
TSH58p_16425	COG3437	response regulator, receiver
TSH58p_16425	COG0784	Response regulator, receiver
TSH58p_16440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_16440	COG4191	Histidine kinase
TSH58p_16470	COG4520	surface antigen
TSH58p_16490	COG0840	transmembrane signaling receptor activity
TSH58p_16500	COG1234	tRNA 3'-trailer cleavage
TSH58p_16505	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TSH58p_16520	COG0523	cobalamin synthesis protein
TSH58p_16525	COG0735	belongs to the Fur family
TSH58p_16535	COG0415	Belongs to the DNA photolyase family
TSH58p_16540	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
TSH58p_16550	COG1201	RNA secondary structure unwinding
TSH58p_16555	COG2226	methyltransferase
TSH58p_16570	COG2267	carboxylic ester hydrolase activity
TSH58p_16575	COG1846	Transcriptional regulator
TSH58p_16585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_16630	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TSH58p_16635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_16640	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_16645	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_16650	COG1960	acyl-CoA dehydrogenase activity
TSH58p_16665	COG2833	Protein of unknown function (DUF455)
TSH58p_16670	COG1218	3'(2'),5'-bisphosphate nucleotidase
TSH58p_16690	COG0366	Alpha amylase catalytic
TSH58p_16695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TSH58p_16705	COG0745	RESPONSE REGULATOR receiver
TSH58p_16710	COG1640	4-alpha-glucanotransferase
TSH58p_16735	COG5002	protein histidine kinase activity
TSH58p_16735	COG2176	DNA-directed DNA polymerase activity
TSH58p_16740	COG1671	Belongs to the UPF0178 family
TSH58p_16745	COG0488	(ABC) transporter
TSH58p_16760	COG2853	Lipoprotein
TSH58p_16780	COG0646	methionine synthase
TSH58p_16780	COG1410	methionine synthase
TSH58p_16795	COG3706	GGDEF domain
TSH58p_16800	COG2070	2-Nitropropane dioxygenase
TSH58p_16805	COG0243	molybdopterin cofactor binding
TSH58p_16815	COG0840	transmembrane signaling receptor activity
TSH58p_16815	COG0840	transmembrane signaling receptor activity
TSH58p_16820	COG2824	Alkylphosphonate utilization operon protein PhnA
TSH58p_16850	COG2205	protein histidine kinase activity
TSH58p_16870	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
TSH58p_16875	COG1752	Esterase of the alpha-beta hydrolase superfamily
TSH58p_16890	COG1773	rubredoxin
TSH58p_16900	COG3108	Peptidase M15
TSH58p_16915	COG0546	phosphoglycolate phosphatase activity
TSH58p_16960	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TSH58p_16965	COG2814	Major facilitator Superfamily
TSH58p_16970	COG3546	catalase activity
TSH58p_16990	COG3411	Ferredoxin
TSH58p_16995	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TSH58p_17005	COG1024	Enoyl-CoA hydratase
TSH58p_17015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TSH58p_17075	COG1492	cobalamin metabolic process
TSH58p_17080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TSH58p_17095	COG3424	synthase
TSH58p_17100	COG1755	Isoprenylcysteine carboxyl methyltransferase
TSH58p_17110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_17120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_17170	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TSH58p_17180	COG2313	pseudouridylate synthase activity
TSH58p_17190	COG1793	dna ligase
TSH58p_17200	COG2153	protein acetylation
TSH58p_17220	COG3685	Protein conserved in bacteria
TSH58p_17240	COG0698	ribose 5-phosphate isomerase
TSH58p_17245	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TSH58p_17250	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TSH58p_17255	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TSH58p_17255	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TSH58p_17265	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TSH58p_17265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TSH58p_17270	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TSH58p_17275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TSH58p_17280	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TSH58p_17290	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TSH58p_17310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TSH58p_17315	COG0416	fatty acid biosynthetic process
TSH58p_17320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TSH58p_17405	COG3723	Recombinational DNA repair protein, rece pathway
TSH58p_17460	COG1396	sequence-specific DNA binding
TSH58p_17825	COG0438	transferase activity, transferring glycosyl groups
TSH58p_17825	COG1216	Glycosyl transferase, family 2
TSH58p_17850	COG0297	glycogen (starch) synthase activity
TSH58p_17860	COG1216	Glycosyl transferase, family 2
TSH58p_17900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_17915	COG4191	Histidine kinase
TSH58p_17915	COG0784	Response regulator, receiver
TSH58p_17950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TSH58p_17950	COG4651	solute:proton antiporter activity
TSH58p_17960	COG3243	poly(R)-hydroxyalkanoic acid synthase
TSH58p_17965	COG3932	Exopolysaccharide synthesis, ExoD
TSH58p_18020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TSH58p_18040	COG1192	Involved in chromosome partitioning
TSH58p_18045	COG1475	DNA binding
TSH58p_18055	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TSH58p_18070	COG1086	Polysaccharide biosynthesis protein
TSH58p_18080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSH58p_18095	COG0494	nUDIX hydrolase
TSH58p_18115	COG0528	UMP kinase activity
TSH58p_18120	COG0528	UMP kinase activity
TSH58p_18145	COG1088	dTDP-glucose 4,6-dehydratase activity
TSH58p_18180	COG3436	PFAM IS66 Orf2 family protein
TSH58p_18265	COG0463	Glycosyl transferase, family 2
TSH58p_18300	COG0463	Glycosyl transferase, family 2
TSH58p_18335	COG0438	transferase activity, transferring glycosyl groups
TSH58p_18340	COG0500	methyltransferase
TSH58p_18345	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TSH58p_18350	COG0579	oxidoreductase
TSH58p_18360	COG0297	glycogen (starch) synthase activity
TSH58p_18365	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TSH58p_18370	COG1088	dTDP-glucose 4,6-dehydratase activity
TSH58p_18375	COG1091	dTDP-4-dehydrorhamnose reductase activity
TSH58p_18395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_18410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_18430	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TSH58p_18440	COG0562	UDP-galactopyranose mutase
TSH58p_18450	COG1216	Glycosyl transferase, family 2
TSH58p_18450	COG0438	transferase activity, transferring glycosyl groups
TSH58p_18470	COG0110	maltose O-acetyltransferase activity
TSH58p_18530	COG1802	Transcriptional regulator
TSH58p_18535	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_18540	COG1917	Cupin 2, conserved barrel domain protein
TSH58p_18560	COG0667	Aldo Keto reductase
TSH58p_18565	COG1802	Transcriptional regulator
TSH58p_18570	COG1803	Methylglyoxal synthase
TSH58p_18580	COG1904	glucuronate isomerase
TSH58p_18585	COG2721	sulfolactate sulfo-lyase activity
TSH58p_18620	COG0861	Integral membrane protein TerC family
TSH58p_18655	COG0191	fructose-bisphosphate aldolase activity
TSH58p_18660	COG3386	PFAM SMP-30 Gluconolaconase
TSH58p_18665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TSH58p_18670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSH58p_18725	COG2022	thiamine diphosphate biosynthetic process
TSH58p_18735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_18735	COG2022	thiamine diphosphate biosynthetic process
TSH58p_18740	COG2239	Acts as a magnesium transporter
TSH58p_18765	COG1254	Belongs to the acylphosphatase family
TSH58p_18805	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_18810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TSH58p_18815	COG2011	ABC-type metal ion transport system permease component
TSH58p_18835	COG0246	Mannitol dehydrogenase
TSH58p_18845	COG0725	ABC transporter, periplasmic molybdate-binding protein
TSH58p_18860	COG5039	Polysaccharide pyruvyl transferase
TSH58p_18865	COG2132	Multicopper oxidase
TSH58p_18875	COG1309	transcriptional regulator
TSH58p_18880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_18885	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSH58p_18890	COG0702	epimerase
TSH58p_18895	COG1733	regulation of RNA biosynthetic process
TSH58p_18905	COG0583	DNA-binding transcription factor activity
TSH58p_18920	COG2133	pyrroloquinoline quinone binding
TSH58p_18955	COG1312	Catalyzes the dehydration of D-mannonate
TSH58p_18960	COG0246	Mannitol dehydrogenase
TSH58p_18985	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TSH58p_18995	COG0148	phosphopyruvate hydratase activity
TSH58p_19000	COG1882	Formate acetyltransferase
TSH58p_19005	COG0837	glucose binding
TSH58p_19005	COG1737	Transcriptional regulator
TSH58p_19020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSH58p_19025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_19030	COG1309	transcriptional regulator
TSH58p_19040	COG5002	protein histidine kinase activity
TSH58p_19045	COG4251	negative regulation of phosphorylation
TSH58p_19050	COG0469	pyruvate kinase activity
TSH58p_19055	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TSH58p_19060	COG2116	formate transmembrane transporter activity
TSH58p_19065	COG0697	spore germination
TSH58p_19070	COG1802	Transcriptional regulator
TSH58p_19075	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_19085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_19090	COG0861	Integral membrane protein TerC family
TSH58p_19095	COG0840	transmembrane signaling receptor activity
TSH58p_19120	COG1749	Flagellar hook protein flgE
TSH58p_19125	COG1256	bacterial-type flagellum assembly
TSH58p_19135	COG1706	bacterial-type flagellum-dependent cell motility
TSH58p_19160	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TSH58p_19165	COG1684	flagellar biosynthetic protein fliR
TSH58p_19170	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TSH58p_19180	COG4794	Type iii secretion
TSH58p_19185	COG1677	Flagellar hook-basal body complex protein FliE
TSH58p_19190	COG1558	bacterial-type flagellum-dependent cell motility
TSH58p_19195	COG1815	bacterial-type flagellum-dependent cell motility
TSH58p_19200	COG1157	protein secretion by the type III secretion system
TSH58p_19215	COG2814	Major facilitator Superfamily
TSH58p_19235	COG5443	negative regulation of bacterial-type flagellum assembly
TSH58p_19245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TSH58p_19250	COG0745	RESPONSE REGULATOR receiver
TSH58p_19270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TSH58p_19275	COG1802	Transcriptional regulator
TSH58p_19290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TSH58p_19295	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
TSH58p_19300	COG1120	ATPase activity
TSH58p_19320	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TSH58p_19330	COG1845	cytochrome c oxidase, subunit III
TSH58p_19335	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_19345	COG0583	DNA-binding transcription factor activity
TSH58p_19355	COG0567	Dehydrogenase, E1 component
TSH58p_19360	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSH58p_19375	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TSH58p_19385	COG0277	FAD linked oxidase domain protein
TSH58p_19415	COG0154	amidase activity
TSH58p_19440	COG0411	ABC transporter
TSH58p_19450	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_19470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TSH58p_19490	COG0683	leucine binding
TSH58p_19495	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_19520	COG3473	Maleate cis-trans isomerase
TSH58p_19525	COG0596	Alpha beta hydrolase
TSH58p_19530	COG2309	aminopeptidase activity
TSH58p_19535	COG1335	isochorismatase
TSH58p_19545	COG1609	Transcriptional regulator
TSH58p_19550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSH58p_19550	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
TSH58p_19555	COG1105	Belongs to the carbohydrate kinase PfkB family
TSH58p_19560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TSH58p_19560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TSH58p_19570	COG3920	Histidine kinase
TSH58p_19575	COG2197	response regulator
TSH58p_19605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_19625	COG0411	ABC transporter
TSH58p_19635	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_19650	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TSH58p_19655	COG0251	oxidation-reduction process
TSH58p_19660	COG1522	sequence-specific DNA binding
TSH58p_19670	COG1414	Transcriptional regulator
TSH58p_19675	COG0280	phosphate acetyltransferase
TSH58p_19695	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_19705	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TSH58p_19710	COG0243	molybdopterin cofactor binding
TSH58p_19715	COG0437	4 iron, 4 sulfur cluster binding
TSH58p_19730	COG0028	Belongs to the TPP enzyme family
TSH58p_19735	COG1475	DNA binding
TSH58p_19740	COG1192	Involved in chromosome partitioning
TSH58p_19760	COG0546	phosphoglycolate phosphatase activity
TSH58p_19765	COG2169	Transcriptional regulator
TSH58p_19765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TSH58p_19770	COG2855	membrane
TSH58p_19810	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TSH58p_19815	COG4191	Histidine kinase
TSH58p_19815	COG0784	Response regulator, receiver
TSH58p_19840	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_19845	COG0028	Belongs to the TPP enzyme family
TSH58p_19850	COG0583	DNA-binding transcription factor activity
TSH58p_19860	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_19865	COG0583	DNA-binding transcription factor activity
TSH58p_19870	COG0793	Belongs to the peptidase S41A family
TSH58p_19875	COG5487	UPF0391 membrane protein
TSH58p_19885	COG4191	Histidine kinase
TSH58p_19895	COG0028	Belongs to the TPP enzyme family
TSH58p_19905	COG1522	sequence-specific DNA binding
TSH58p_19930	COG3300	MHYT domain
TSH58p_19930	COG5001	Diguanylate cyclase
TSH58p_19955	COG2985	domain, Protein
TSH58p_19975	COG3842	ATPase activity
TSH58p_19985	COG0588	phosphoglycerate mutase activity
TSH58p_20000	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_20000	COG1454	alcohol dehydrogenase
TSH58p_20080	COG0583	DNA-binding transcription factor activity
TSH58p_20105	COG1360	Flagellar Motor Protein
TSH58p_20110	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TSH58p_20120	COG4786	Flagellar basal body rod
TSH58p_20125	COG4786	Flagellar basal body rod
TSH58p_20130	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
TSH58p_20135	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TSH58p_20155	COG0243	molybdopterin cofactor binding
TSH58p_20165	COG3005	denitrification pathway
TSH58p_20220	COG1766	The M ring may be actively involved in energy transduction
TSH58p_20230	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TSH58p_20235	COG1338	Plays a role in the flagellum-specific transport system
TSH58p_20245	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TSH58p_20265	COG0745	RESPONSE REGULATOR receiver
TSH58p_20300	COG3416	Protein conserved in bacteria
TSH58p_20305	COG0628	permease
TSH58p_20315	COG1597	lipid kinase activity
TSH58p_20320	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_20325	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
TSH58p_20330	COG1802	Transcriptional regulator
TSH58p_20350	COG0668	transmembrane transport
TSH58p_20400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TSH58p_20400	COG2226	methyltransferase
TSH58p_20400	COG0596	Alpha beta hydrolase
TSH58p_20405	COG0183	Belongs to the thiolase family
TSH58p_20410	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_20420	COG2814	Major facilitator Superfamily
TSH58p_20425	COG0583	DNA-binding transcription factor activity
TSH58p_20435	COG5001	Diguanylate cyclase
TSH58p_20435	COG4251	negative regulation of phosphorylation
TSH58p_20435	COG2203	Gaf domain
TSH58p_20435	COG3706	GGDEF domain
TSH58p_20440	COG0012	GTP binding
TSH58p_20460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TSH58p_20460	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TSH58p_20485	COG1131	(ABC) transporter
TSH58p_20515	COG3383	formate dehydrogenase (NAD+) activity
TSH58p_20520	COG1414	Transcriptional regulator
TSH58p_20545	COG4191	Histidine kinase
TSH58p_20555	COG0402	S-adenosylhomocysteine deaminase activity
TSH58p_20565	COG4603	Belongs to the binding-protein-dependent transport system permease family
TSH58p_20580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TSH58p_20590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TSH58p_20590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TSH58p_20605	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TSH58p_20730	COG4964	Belongs to the GSP D family
TSH58p_20750	COG1858	cytochrome C peroxidase
TSH58p_20780	COG0405	Gamma-glutamyltransferase
TSH58p_20800	COG2199	diguanylate cyclase activity
TSH58p_20800	COG2203	Gaf domain
TSH58p_20810	COG0784	Response regulator, receiver
TSH58p_20810	COG4191	Histidine kinase
TSH58p_20815	COG1132	(ABC) transporter
TSH58p_20885	COG1595	DNA-templated transcription, initiation
TSH58p_20900	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_20905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_20915	COG2301	Belongs to the HpcH HpaI aldolase family
TSH58p_20925	COG2079	MmgE PrpD family protein
TSH58p_20930	COG1960	acyl-CoA dehydrogenase activity
TSH58p_20935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_20950	COG0154	amidase activity
TSH58p_20965	COG2188	Transcriptional regulator
TSH58p_20980	COG0798	PFAM Bile acid sodium symporter
TSH58p_20985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_20995	COG4166	transmembrane transport
TSH58p_21020	COG4251	negative regulation of phosphorylation
TSH58p_21025	COG0784	Response regulator, receiver
TSH58p_21050	COG4191	Histidine kinase
TSH58p_21070	COG1595	DNA-templated transcription, initiation
TSH58p_21080	COG1045	serine acetyltransferase
TSH58p_21095	COG3842	ATPase activity
TSH58p_21100	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_21105	COG1178	ABC-type Fe3 transport system permease component
TSH58p_21115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TSH58p_21120	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TSH58p_21125	COG2233	PERMEase
TSH58p_21135	COG0747	negative chemotaxis
TSH58p_21140	COG0601	transmembrane transport
TSH58p_21155	COG4608	Belongs to the ABC transporter superfamily
TSH58p_21160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_21170	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_21215	COG0484	heat shock protein binding
TSH58p_21225	COG0564	pseudouridine synthase activity
TSH58p_21240	COG0156	8-amino-7-oxononanoate synthase activity
TSH58p_21250	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TSH58p_21250	COG4106	trans-aconitate 2-methyltransferase activity
TSH58p_21260	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TSH58p_21270	COG0574	Belongs to the PEP-utilizing enzyme family
TSH58p_21270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSH58p_21275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TSH58p_21280	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TSH58p_21285	COG1278	Cold shock
TSH58p_21290	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_21320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TSH58p_21325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TSH58p_21335	COG1172	Belongs to the binding-protein-dependent transport system permease family
TSH58p_21340	COG1172	Belongs to the binding-protein-dependent transport system permease family
TSH58p_21345	COG1129	ABC transporter
TSH58p_21350	COG1879	ABC-type sugar transport system periplasmic component
TSH58p_21385	COG4214	carbohydrate transport
TSH58p_21395	COG0129	dihydroxy-acid dehydratase activity
TSH58p_21410	COG1802	Transcriptional regulator
TSH58p_21415	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_21420	COG1917	Cupin 2, conserved barrel domain protein
TSH58p_21425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_21440	COG0667	Aldo Keto reductase
TSH58p_21445	COG1802	Transcriptional regulator
TSH58p_21465	COG2721	sulfolactate sulfo-lyase activity
TSH58p_21475	COG1923	regulation of RNA biosynthetic process
TSH58p_21510	COG2204	response regulator
TSH58p_21520	COG0569	domain protein
TSH58p_21535	COG1923	regulation of RNA biosynthetic process
TSH58p_21540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TSH58p_21555	COG0483	inositol monophosphate 1-phosphatase activity
TSH58p_21570	COG3956	TIGRFAM MazG family protein
TSH58p_21575	COG3260	NADH ubiquinone oxidoreductase 20
TSH58p_21580	COG0649	NAD binding
TSH58p_21585	COG0651	ATP synthesis coupled electron transport
TSH58p_21595	COG0650	Formate hydrogenlyase subunit 4
TSH58p_21600	COG0651	ATP synthesis coupled electron transport
TSH58p_21610	COG2183	response to ionizing radiation
TSH58p_21620	COG1280	lysine exporter protein (LysE YggA)
TSH58p_21650	COG0393	Putative heavy-metal-binding
TSH58p_21655	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TSH58p_21670	COG4166	transmembrane transport
TSH58p_21675	COG0625	glutathione transferase activity
TSH58p_21680	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSH58p_21685	COG0366	Alpha amylase catalytic
TSH58p_21745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSH58p_21755	COG0583	DNA-binding transcription factor activity
TSH58p_21760	COG4336	lyase activity
TSH58p_21785	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TSH58p_21790	COG1984	allophanate hydrolase subunit 2
TSH58p_21795	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TSH58p_21805	COG4191	Histidine kinase
TSH58p_21810	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TSH58p_21815	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TSH58p_21820	COG0058	SHG alpha-glucan phosphorylase activity
TSH58p_21830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TSH58p_21865	COG5002	protein histidine kinase activity
TSH58p_21870	COG0745	RESPONSE REGULATOR receiver
TSH58p_21900	COG1959	2 iron, 2 sulfur cluster binding
TSH58p_21905	COG0719	Fe-S assembly protein
TSH58p_21910	COG0396	ATPase activity
TSH58p_21915	COG0719	Fe-S assembly protein
TSH58p_21920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TSH58p_21925	COG0822	iron-sulfur transferase activity
TSH58p_21930	COG0489	protein tyrosine kinase activity
TSH58p_21935	COG0316	Belongs to the HesB IscA family
TSH58p_21955	COG0308	aminopeptidase N
TSH58p_21975	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TSH58p_22010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TSH58p_22015	COG0697	spore germination
TSH58p_22025	COG2814	Major facilitator Superfamily
TSH58p_22030	COG0583	DNA-binding transcription factor activity
TSH58p_22045	COG3383	formate dehydrogenase (NAD+) activity
TSH58p_22050	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TSH58p_22065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSH58p_22070	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSH58p_22090	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TSH58p_22100	COG0129	dihydroxy-acid dehydratase activity
TSH58p_22115	COG3920	Histidine kinase
TSH58p_22140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TSH58p_22145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TSH58p_22150	COG0534	Mate efflux family protein
TSH58p_22195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TSH58p_22235	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TSH58p_22350	COG4974	Belongs to the 'phage' integrase family
TSH58p_22355	COG0629	single-stranded DNA binding
TSH58p_22360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TSH58p_22390	COG1562	ergosterol biosynthetic process
TSH58p_22395	COG1562	ergosterol biosynthetic process
TSH58p_22400	COG1233	COG1233 Phytoene dehydrogenase and related
TSH58p_22410	COG3737	Protein of unknown function (DUF498/DUF598)
TSH58p_22440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TSH58p_22450	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TSH58p_22455	COG3706	GGDEF domain
TSH58p_22460	COG0805	protein transport
TSH58p_22465	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TSH58p_22470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TSH58p_22475	COG3842	ATPase activity
TSH58p_22480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TSH58p_22485	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TSH58p_22490	COG1994	Peptidase M50
TSH58p_22495	COG1472	Belongs to the glycosyl hydrolase 3 family
TSH58p_22510	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TSH58p_22515	COG0316	Belongs to the HesB IscA family
TSH58p_22520	COG0708	Exodeoxyribonuclease III
TSH58p_22605	COG0464	growth
TSH58p_22620	COG3772	lysozyme
TSH58p_22810	COG0519	Catalyzes the synthesis of GMP from XMP
TSH58p_22815	COG1247	-acetyltransferase
TSH58p_22830	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TSH58p_22830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TSH58p_22850	COG3813	Protein conserved in bacteria
TSH58p_22855	COG0357	Ribosomal RNA small subunit methyltransferase G
TSH58p_22855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TSH58p_22880	COG3706	GGDEF domain
TSH58p_22880	COG0745	RESPONSE REGULATOR receiver
TSH58p_22885	COG0066	3-isopropylmalate dehydratase activity
TSH58p_22890	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TSH58p_22900	COG1335	isochorismatase
TSH58p_22940	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_22945	COG0683	leucine binding
TSH58p_22950	COG2188	Transcriptional regulator
TSH58p_22975	COG0411	ABC transporter
TSH58p_22995	COG5002	protein histidine kinase activity
TSH58p_22995	COG2198	Histidine kinase
TSH58p_22995	COG0784	Response regulator, receiver
TSH58p_23015	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TSH58p_23020	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
TSH58p_23040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_23045	COG0601	transmembrane transport
TSH58p_23065	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_23070	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
TSH58p_23075	COG1301	dicarboxylic acid transport
TSH58p_23080	COG2828	Protein conserved in bacteria
TSH58p_23085	COG0583	DNA-binding transcription factor activity
TSH58p_23105	COG0745	RESPONSE REGULATOR receiver
TSH58p_23110	COG5002	protein histidine kinase activity
TSH58p_23115	COG2204	response regulator
TSH58p_23120	COG3852	Histidine kinase
TSH58p_23125	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_23170	COG0270	DNA (cytosine-5-)-methyltransferase activity
TSH58p_23195	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TSH58p_23250	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TSH58p_23280	COG2862	Uncharacterized protein family, UPF0114
TSH58p_23390	COG3501	Rhs element vgr protein
TSH58p_23405	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TSH58p_23425	COG4771	TonB-dependent receptor
TSH58p_23430	COG0477	Major facilitator Superfamily
TSH58p_23445	COG1169	isochorismate synthase
TSH58p_23450	COG1021	2,3-dihydroxybenzoate-AMP ligase
TSH58p_23455	COG3433	isochorismatase activity
TSH58p_23455	COG1535	isochorismatase
TSH58p_23460	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_23470	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TSH58p_23475	COG2382	esterase
TSH58p_23485	COG1595	DNA-templated transcription, initiation
TSH58p_23495	COG1882	Formate acetyltransferase
TSH58p_23505	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TSH58p_23505	COG3008	intermembrane lipid transfer
TSH58p_23510	COG2995	paraquat-inducible protein a
TSH58p_23520	COG0859	PFAM glycosyl transferase family 9
TSH58p_23520	COG0457	Tetratricopeptide repeat
TSH58p_23525	COG0281	malic enzyme
TSH58p_23525	COG0280	phosphate acetyltransferase
TSH58p_23530	COG1301	dicarboxylic acid transport
TSH58p_23535	COG4191	Histidine kinase
TSH58p_23540	COG2204	response regulator
TSH58p_23555	COG1268	BioY protein
TSH58p_23565	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TSH58p_23575	COG1794	racemase activity, acting on amino acids and derivatives
TSH58p_23590	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_23600	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_23605	COG3976	FMN-binding domain protein
TSH58p_23605	COG0431	NADPH-dependent FMN reductase
TSH58p_23605	COG1053	succinate dehydrogenase
TSH58p_23625	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_23635	COG0840	transmembrane signaling receptor activity
TSH58p_23640	COG0745	RESPONSE REGULATOR receiver
TSH58p_23645	COG0745	RESPONSE REGULATOR receiver
TSH58p_23650	COG4251	negative regulation of phosphorylation
TSH58p_23660	COG1733	regulation of RNA biosynthetic process
TSH58p_23685	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TSH58p_23695	COG1846	Transcriptional regulator
TSH58p_23725	COG0644	oxidoreductase
TSH58p_23750	COG3547	Transposase (IS116 IS110 IS902 family)
TSH58p_23780	COG3436	PFAM IS66 Orf2 family protein
TSH58p_23805	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TSH58p_23840	COG3335	DDE superfamily endonuclease
TSH58p_23845	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TSH58p_23855	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TSH58p_23875	COG0425	Belongs to the sulfur carrier protein TusA family
TSH58p_23885	COG0640	Transcriptional regulator
TSH58p_23905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TSH58p_23905	COG2857	Cytochrome c1
TSH58p_23920	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TSH58p_23925	COG0408	coproporphyrinogen oxidase activity
TSH58p_23930	COG0617	tRNA 3'-terminal CCA addition
TSH58p_23950	COG0714	Associated with various cellular activities
TSH58p_23995	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_24000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSH58p_24060	COG2099	Precorrin-6x reductase
TSH58p_24090	COG1797	cobyrinic acid a,c-diamide synthase activity
TSH58p_24095	COG0778	Nitroreductase
TSH58p_24100	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_24105	COG1309	transcriptional regulator
TSH58p_24110	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TSH58p_24115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSH58p_24120	COG0737	Belongs to the 5'-nucleotidase family
TSH58p_24145	COG1749	Flagellar hook protein flgE
TSH58p_24145	COG1749	Flagellar hook protein flgE
TSH58p_24170	COG0795	lipopolysaccharide-transporting ATPase activity
TSH58p_24175	COG0840	transmembrane signaling receptor activity
TSH58p_24180	COG1137	ATPase activity
TSH58p_24190	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSH58p_24240	COG2723	6-phospho-beta-galactosidase activity
TSH58p_24255	COG2086	electron transfer activity
TSH58p_24265	COG1250	3-hydroxyacyl-CoA dehydrogenase
TSH58p_24275	COG1073	alpha beta
TSH58p_24280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TSH58p_24295	COG0019	diaminopimelate decarboxylase activity
TSH58p_24320	COG0772	Belongs to the SEDS family
TSH58p_24330	COG0745	RESPONSE REGULATOR receiver
TSH58p_24350	COG1253	flavin adenine dinucleotide binding
TSH58p_24360	COG2205	protein histidine kinase activity
TSH58p_24375	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
TSH58p_24395	COG1657	PFAM Prenyltransferase squalene oxidase
TSH58p_24420	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSH58p_24455	COG1741	Belongs to the pirin family
TSH58p_24460	COG2860	membrane
TSH58p_24470	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TSH58p_24475	COG0789	Transcriptional regulator
TSH58p_24490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSH58p_24535	COG1566	PFAM secretion protein HlyD family protein
TSH58p_24545	COG0583	DNA-binding transcription factor activity
TSH58p_24550	COG2814	Major facilitator Superfamily
TSH58p_24555	COG0656	L-ascorbic acid biosynthetic process
TSH58p_24560	COG0471	metal ion transport
TSH58p_24560	COG3273	potassium ion transport
TSH58p_24590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_24600	COG0583	DNA-binding transcription factor activity
TSH58p_24605	COG3842	ATPase activity
TSH58p_24610	COG2182	Extracellular solute-binding protein
TSH58p_24615	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_24625	COG1396	sequence-specific DNA binding
TSH58p_24625	COG1917	Cupin 2, conserved barrel domain protein
TSH58p_24635	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TSH58p_24645	COG5507	3-demethylubiquinone-9 3-methyltransferase
TSH58p_24660	COG1309	transcriptional regulator
TSH58p_24685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TSH58p_24695	COG1522	sequence-specific DNA binding
TSH58p_24700	COG1192	Involved in chromosome partitioning
TSH58p_24730	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TSH58p_24735	COG1530	ribonuclease E activity
TSH58p_24745	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TSH58p_24760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TSH58p_24770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TSH58p_24790	COG5002	protein histidine kinase activity
TSH58p_24815	COG0588	phosphoglycerate mutase activity
TSH58p_24820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TSH58p_24830	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
TSH58p_24840	COG3693	PFAM glycoside hydrolase, family 10
TSH58p_24850	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TSH58p_24875	COG1215	transferase activity, transferring glycosyl groups
TSH58p_24880	COG0438	transferase activity, transferring glycosyl groups
TSH58p_24885	COG0438	transferase activity, transferring glycosyl groups
TSH58p_24905	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_24910	COG0367	asparagine synthase
TSH58p_24915	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TSH58p_24960	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TSH58p_24965	COG4208	sulfate ABC transporter
TSH58p_24975	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TSH58p_24985	COG1959	2 iron, 2 sulfur cluster binding
TSH58p_24990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TSH58p_25015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_25040	COG1573	uracil-dna glycosylase
TSH58p_25045	COG0741	lytic transglycosylase activity
TSH58p_25050	COG0521	Mo-molybdopterin cofactor biosynthetic process
TSH58p_25085	COG0297	glycogen (starch) synthase activity
TSH58p_25125	COG1960	acyl-CoA dehydrogenase activity
TSH58p_25135	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
TSH58p_25145	COG0583	DNA-binding transcription factor activity
TSH58p_25150	COG2080	2 iron, 2 sulfur cluster binding
TSH58p_25155	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TSH58p_25160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TSH58p_25180	COG2900	Belongs to the SlyX family
TSH58p_25210	COG0840	transmembrane signaling receptor activity
TSH58p_25320	COG1201	RNA secondary structure unwinding
TSH58p_25375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TSH58p_25380	COG1063	alcohol dehydrogenase
TSH58p_25385	COG4948	Mandelate Racemase Muconate Lactonizing
TSH58p_25390	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_25410	COG0583	DNA-binding transcription factor activity
TSH58p_25500	COG0420	3'-5' exonuclease activity
TSH58p_25510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSH58p_25520	COG1192	Involved in chromosome partitioning
TSH58p_25525	COG1475	DNA binding
TSH58p_25540	COG3707	response regulator
TSH58p_25545	COG1116	anion transmembrane transporter activity
TSH58p_25555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSH58p_25560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TSH58p_25565	COG2146	nitrite reductase [NAD(P)H] activity
TSH58p_25570	COG0243	molybdopterin cofactor binding
TSH58p_25575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TSH58p_25575	COG1648	precorrin-2 dehydrogenase activity
TSH58p_25590	COG1032	radical SAM domain protein
TSH58p_25640	COG1609	Transcriptional regulator
TSH58p_25645	COG0583	DNA-binding transcription factor activity
TSH58p_25660	COG3195	allantoin biosynthetic process
TSH58p_25660	COG3648	Uricase
TSH58p_25670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_25695	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TSH58p_25735	COG3383	formate dehydrogenase (NAD+) activity
TSH58p_25735	COG0243	molybdopterin cofactor binding
TSH58p_25740	COG0437	4 iron, 4 sulfur cluster binding
TSH58p_25745	COG2864	formate dehydrogenase
TSH58p_25750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_25775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_25785	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_25800	COG0745	RESPONSE REGULATOR receiver
TSH58p_25805	COG3850	Histidine kinase
TSH58p_25805	COG0642	Histidine kinase
TSH58p_25840	COG2223	nitrite transmembrane transporter activity
TSH58p_25875	COG1137	ATPase activity
TSH58p_25880	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TSH58p_25885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TSH58p_25890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TSH58p_25895	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TSH58p_25900	COG0527	aspartate kinase activity
TSH58p_25920	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TSH58p_25925	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TSH58p_25935	COG2852	Protein conserved in bacteria
TSH58p_25940	COG2890	protein-(glutamine-N5) methyltransferase activity
TSH58p_25960	COG0542	response to heat
TSH58p_25965	COG1272	protein, Hemolysin III
TSH58p_25975	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TSH58p_25990	COG0840	transmembrane signaling receptor activity
TSH58p_25995	COG5265	(ABC) transporter
TSH58p_26005	COG1703	isobutyryl-CoA mutase activity
TSH58p_26015	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TSH58p_26025	COG2137	regulation of response to DNA damage stimulus
TSH58p_26030	COG0842	Transport permease protein
TSH58p_26035	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TSH58p_26040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TSH58p_26045	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TSH58p_26055	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TSH58p_26060	COG0671	phosphoesterase, PA-phosphatase related
TSH58p_26075	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TSH58p_26080	COG4774	siderophore transport
TSH58p_26085	COG3128	pkhd-type hydroxylase
TSH58p_26100	COG4604	ABC transporter, ATP-binding protein
TSH58p_26105	COG4605	iron ion homeostasis
TSH58p_26110	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSH58p_26115	COG4607	ABC-type enterochelin transport system periplasmic component
TSH58p_26120	COG1695	Transcriptional regulator
TSH58p_26160	COG1116	anion transmembrane transporter activity
TSH58p_26160	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSH58p_26235	COG4206	TonB-dependent receptor
TSH58p_26275	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TSH58p_26280	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TSH58p_26280	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TSH58p_26285	COG1660	Displays ATPase and GTPase activities
TSH58p_26290	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TSH58p_26300	COG0642	Histidine kinase
TSH58p_26305	COG0745	RESPONSE REGULATOR receiver
TSH58p_26320	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TSH58p_26335	COG0739	heme binding
TSH58p_26375	COG1942	4-Oxalocrotonate Tautomerase
TSH58p_26380	COG0235	Class ii aldolase
TSH58p_26400	COG0243	molybdopterin cofactor binding
TSH58p_26400	COG3383	formate dehydrogenase (NAD+) activity
TSH58p_26405	COG0437	4 iron, 4 sulfur cluster binding
TSH58p_26410	COG2864	formate dehydrogenase
TSH58p_26415	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TSH58p_26425	COG2205	protein histidine kinase activity
TSH58p_26430	COG0745	RESPONSE REGULATOR receiver
TSH58p_26445	COG0840	transmembrane signaling receptor activity
TSH58p_26455	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TSH58p_26465	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TSH58p_26485	COG1073	alpha beta
TSH58p_26485	COG2226	methyltransferase
TSH58p_26495	COG2027	D-alanyl-D-alanine carboxypeptidase
TSH58p_26505	COG2091	lysine biosynthetic process via aminoadipic acid
TSH58p_26510	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TSH58p_26515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TSH58p_26525	COG2111	Na H antiporter
TSH58p_26525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TSH58p_26530	COG1006	Multisubunit Na H antiporter MnhC subunit
TSH58p_26535	COG0651	ATP synthesis coupled electron transport
TSH58p_26540	COG1863	multisubunit Na H antiporter MnhE subunit
TSH58p_26545	COG2212	antiporter activity
TSH58p_26550	COG1320	monovalent cation:proton antiporter activity
TSH58p_26590	COG4615	Cyclic peptide transporter
TSH58p_26625	COG0683	leucine binding
TSH58p_26650	COG3842	ATPase activity
TSH58p_26660	COG1175	transmembrane transport
TSH58p_26680	COG1024	Enoyl-CoA hydratase
TSH58p_26695	COG4221	oxidoreductase activity
TSH58p_26700	COG1609	Transcriptional regulator
TSH58p_26730	COG1966	Carbon starvation protein
TSH58p_26735	COG2879	small protein
TSH58p_26750	COG4221	oxidoreductase activity
TSH58p_26760	COG2186	Transcriptional regulator
TSH58p_26770	COG0765	amino acid transport
TSH58p_26810	COG0840	transmembrane signaling receptor activity
TSH58p_26855	COG2814	Major facilitator Superfamily
TSH58p_26860	COG0583	DNA-binding transcription factor activity
TSH58p_26865	COG0747	negative chemotaxis
TSH58p_26870	COG0601	transmembrane transport
TSH58p_26885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSH58p_26890	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_26895	COG3842	ATPase activity
TSH58p_26905	COG0277	FAD linked oxidase domain protein
TSH58p_26920	COG3685	Protein conserved in bacteria
TSH58p_26950	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TSH58p_26955	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSH58p_26970	COG0187	DNA topoisomerase II activity
TSH58p_26975	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TSH58p_26980	COG0592	DNA-directed DNA polymerase activity
TSH58p_27030	COG4566	intracellular signal transduction
TSH58p_27035	COG4191	Histidine kinase
TSH58p_27040	COG1335	isochorismatase
TSH58p_27105	COG0625	glutathione transferase activity
TSH58p_27110	COG0583	DNA-binding transcription factor activity
TSH58p_27115	COG4948	Mandelate Racemase Muconate Lactonizing
TSH58p_27130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TSH58p_27145	COG0583	DNA-binding transcription factor activity
TSH58p_27155	COG1283	sodium-dependent phosphate transmembrane transporter activity
TSH58p_27215	COG0306	phosphate transporter
TSH58p_27220	COG1392	Phosphate transport regulator
TSH58p_27230	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSH58p_27235	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TSH58p_27250	COG0716	FMN binding
TSH58p_27255	COG2223	nitrite transmembrane transporter activity
TSH58p_27285	COG0612	Peptidase, M16
TSH58p_27295	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
TSH58p_27310	COG0409	Hydrogenase expression formation protein
TSH58p_27315	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSH58p_27325	COG0488	(ABC) transporter
TSH58p_27340	COG2249	NAD(P)H dehydrogenase (quinone) activity
TSH58p_27355	COG0586	Pfam SNARE associated Golgi protein
TSH58p_27385	COG2884	Cell division ATP-binding protein ftsE
TSH58p_27395	COG1309	transcriptional regulator
TSH58p_27420	COG5001	Diguanylate cyclase
TSH58p_27425	COG1381	Involved in DNA repair and RecF pathway recombination
TSH58p_27430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TSH58p_27435	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSH58p_27440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_27460	COG2308	Evidence 4 Homologs of previously reported genes of
TSH58p_27465	COG1360	Flagellar Motor Protein
TSH58p_27475	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TSH58p_27500	COG0643	Histidine kinase
TSH58p_27500	COG2198	Histidine kinase
TSH58p_27505	COG0835	chemotaxis
TSH58p_27510	COG0745	RESPONSE REGULATOR receiver
TSH58p_27525	COG0583	DNA-binding transcription factor activity
TSH58p_27535	COG0745	RESPONSE REGULATOR receiver
TSH58p_27540	COG1157	protein secretion by the type III secretion system
TSH58p_27550	COG3300	MHYT domain
TSH58p_27550	COG5001	Diguanylate cyclase
TSH58p_27565	COG0455	bacterial-type flagellum organization
TSH58p_27570	COG0552	protein localization to endoplasmic reticulum
TSH58p_27575	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TSH58p_27580	COG2204	response regulator
TSH58p_27585	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
TSH58p_27590	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TSH58p_27600	COG1766	The M ring may be actively involved in energy transduction
TSH58p_27605	COG1396	sequence-specific DNA binding
TSH58p_27645	COG1686	Belongs to the peptidase S11 family
TSH58p_27660	COG1840	ABC-type Fe3 transport system, periplasmic component
TSH58p_27665	COG4149	molybdate abc transporter
TSH58p_27670	COG3842	ATPase activity
TSH58p_27685	COG2391	methyltransferase activity
TSH58p_27695	COG0583	DNA-binding transcription factor activity
TSH58p_27700	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
TSH58p_27705	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
TSH58p_27730	COG0246	Mannitol dehydrogenase
TSH58p_27735	COG2721	sulfolactate sulfo-lyase activity
TSH58p_27740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_27750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_27755	COG1063	alcohol dehydrogenase
TSH58p_27800	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
TSH58p_27800	COG3264	Mechanosensitive ion channel
TSH58p_27810	COG2814	Major facilitator Superfamily
TSH58p_27815	COG0386	Belongs to the glutathione peroxidase family
TSH58p_27835	COG1737	Transcriptional regulator
TSH58p_27835	COG0837	glucose binding
TSH58p_27840	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TSH58p_27845	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSH58p_27850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_27860	COG0179	Fumarylacetoacetate (FAA) hydrolase
TSH58p_27875	COG0436	Aminotransferase
TSH58p_27880	COG2205	protein histidine kinase activity
TSH58p_27885	COG2373	Large extracellular alpha-helical protein
TSH58p_27900	COG0183	Belongs to the thiolase family
TSH58p_27905	COG1024	Enoyl-CoA hydratase
TSH58p_27905	COG1250	3-hydroxyacyl-CoA dehydrogenase
TSH58p_27910	COG1960	acyl-CoA dehydrogenase activity
TSH58p_27925	COG3047	cAMP biosynthetic process
TSH58p_27940	COG1196	nuclear chromosome segregation
TSH58p_27955	COG1194	a g-specific adenine glycosylase
TSH58p_27965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_27965	COG4191	Histidine kinase
TSH58p_27975	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TSH58p_27985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TSH58p_27985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_27990	COG3012	SEC-C Motif Domain Protein
TSH58p_27995	COG1278	Cold shock
TSH58p_28000	COG0793	Belongs to the peptidase S41A family
TSH58p_28020	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TSH58p_28030	COG0375	protein maturation
TSH58p_28045	COG0298	carbon dioxide binding
TSH58p_28070	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TSH58p_28075	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TSH58p_28080	COG5557	Pfam Polysulphide reductase, NrfD
TSH58p_28085	COG0437	4 iron, 4 sulfur cluster binding
TSH58p_28090	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
TSH58p_28105	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TSH58p_28130	COG4178	(ABC) transporter
TSH58p_28140	COG0625	glutathione transferase activity
TSH58p_28165	COG1640	4-alpha-glucanotransferase
TSH58p_28185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_28195	COG2205	protein histidine kinase activity
TSH58p_28200	COG0745	RESPONSE REGULATOR receiver
TSH58p_28205	COG0784	Response regulator, receiver
TSH58p_28205	COG2198	Histidine kinase
TSH58p_28205	COG2205	protein histidine kinase activity
TSH58p_28210	COG1278	Cold shock
TSH58p_28220	COG1846	Transcriptional regulator
TSH58p_28225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TSH58p_28230	COG0556	nucleotide-excision repair
TSH58p_28250	COG2205	protein histidine kinase activity
TSH58p_28255	COG2927	DNA polymerase III (CHI subunit)
TSH58p_28260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TSH58p_28270	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TSH58p_28275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TSH58p_28290	COG0741	lytic transglycosylase activity
TSH58p_28305	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TSH58p_28315	COG1561	YicC-like family, N-terminal region
TSH58p_28320	COG0300	oxidoreductase activity
TSH58p_28325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TSH58p_28330	COG3932	Exopolysaccharide synthesis, ExoD
TSH58p_28335	COG0488	(ABC) transporter
TSH58p_28340	COG0105	UTP biosynthetic process
TSH58p_28355	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TSH58p_28360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TSH58p_28370	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TSH58p_28375	COG0628	permease
TSH58p_28385	COG0300	oxidoreductase activity
TSH58p_28390	COG3025	triphosphatase activity
TSH58p_28400	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TSH58p_28405	COG0248	Ppx GppA phosphatase
TSH58p_28415	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TSH58p_28420	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TSH58p_28440	COG5002	protein histidine kinase activity
TSH58p_28440	COG5001	Diguanylate cyclase
TSH58p_28440	COG3447	MASE1 domain protein
TSH58p_28445	COG2205	protein histidine kinase activity
TSH58p_28445	COG2202	Pas domain
TSH58p_28450	COG0784	Response regulator, receiver
TSH58p_28455	COG3706	GGDEF domain
TSH58p_28455	COG0745	RESPONSE REGULATOR receiver
TSH58p_28460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TSH58p_28465	COG0793	Belongs to the peptidase S41A family
TSH58p_28470	COG0557	exoribonuclease II activity
TSH58p_28480	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TSH58p_28485	COG0758	DNA mediated transformation
TSH58p_28505	COG2814	Major facilitator Superfamily
TSH58p_28540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSH58p_28540	COG2205	protein histidine kinase activity
TSH58p_28545	COG0745	RESPONSE REGULATOR receiver
TSH58p_28580	COG0581	inorganic phosphate transmembrane transporter activity
TSH58p_28585	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_28595	COG3842	ATPase activity
TSH58p_28605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TSH58p_28610	COG1732	Glycine betaine
TSH58p_28615	COG1174	glycine betaine transport
TSH58p_28620	COG1125	glycine betaine transport
TSH58p_28625	COG1174	glycine betaine transport
TSH58p_28635	COG1652	LysM domain
TSH58p_28640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSH58p_28650	COG1024	Enoyl-CoA hydratase
TSH58p_28655	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TSH58p_28660	COG1609	Transcriptional regulator
TSH58p_28665	COG3265	gluconokinase activity
TSH58p_28680	COG1609	Transcriptional regulator
TSH58p_28685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TSH58p_28690	COG1126	abc transporter atp-binding protein
TSH58p_28700	COG0765	amino acid transport
TSH58p_28705	COG0765	amino acid transport
TSH58p_28710	COG0303	'Molybdopterin
TSH58p_28730	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_28735	COG0730	response to heat
TSH58p_28750	COG0717	Belongs to the dCTP deaminase family
TSH58p_28760	COG0625	glutathione transferase activity
TSH58p_28765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TSH58p_28785	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TSH58p_28785	COG2813	Specifically methylates the guanine in position
TSH58p_28790	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TSH58p_28800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TSH58p_28805	COG0287	Prephenate dehydrogenase
TSH58p_28810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TSH58p_28820	COG0583	DNA-binding transcription factor activity
TSH58p_28825	COG0450	alkyl hydroperoxide reductase
TSH58p_28830	COG3634	alkyl hydroperoxide reductase activity
TSH58p_28835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TSH58p_28840	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
TSH58p_28845	COG2080	2 iron, 2 sulfur cluster binding
TSH58p_28855	COG1988	membrane-bound metal-dependent
TSH58p_28880	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TSH58p_28885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TSH58p_28890	COG0540	Belongs to the ATCase OTCase family
TSH58p_28905	COG0583	DNA-binding transcription factor activity
TSH58p_28930	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TSH58p_28935	COG0840	transmembrane signaling receptor activity
TSH58p_28940	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TSH58p_28945	COG0154	amidase activity
TSH58p_28950	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TSH58p_28990	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TSH58p_28995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_29005	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
TSH58p_29010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TSH58p_29035	COG0667	Aldo Keto reductase
TSH58p_29045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TSH58p_29080	COG2703	oxygen carrier activity
TSH58p_29095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TSH58p_29100	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TSH58p_29105	COG1127	ABC transporter
TSH58p_29125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TSH58p_29130	COG1271	oxidase subunit
TSH58p_29135	COG1294	oxidase, subunit
TSH58p_29165	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_29190	COG2089	acid synthase
TSH58p_29195	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
TSH58p_29225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TSH58p_29230	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TSH58p_29245	COG0457	Tetratricopeptide repeat
TSH58p_29245	COG0859	PFAM glycosyl transferase family 9
TSH58p_29255	COG0859	PFAM glycosyl transferase family 9
TSH58p_29255	COG0457	Tetratricopeptide repeat
TSH58p_29305	COG0784	Response regulator, receiver
TSH58p_29330	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TSH58p_29340	COG1228	amidohydrolase
TSH58p_29345	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TSH58p_29360	COG2226	methyltransferase
TSH58p_29370	COG0747	negative chemotaxis
TSH58p_29375	COG0601	transmembrane transport
TSH58p_29380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_29385	COG0444	Belongs to the ABC transporter superfamily
TSH58p_29390	COG4608	Belongs to the ABC transporter superfamily
TSH58p_29425	COG1666	GTP binding
TSH58p_29445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TSH58p_29450	COG5001	Diguanylate cyclase
TSH58p_29480	COG1752	Esterase of the alpha-beta hydrolase superfamily
TSH58p_29485	COG1132	(ABC) transporter
TSH58p_29490	COG4191	Histidine kinase
TSH58p_29515	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TSH58p_29525	COG2264	protein methyltransferase activity
TSH58p_29530	COG0583	DNA-binding transcription factor activity
TSH58p_29535	COG0655	NAD(P)H dehydrogenase (quinone) activity
TSH58p_29540	COG0435	Glutathione S-transferase
TSH58p_29550	COG2197	response regulator
TSH58p_29560	COG0492	ferredoxin-NADP+ reductase activity
TSH58p_29595	COG0501	Belongs to the peptidase M48B family
TSH58p_29605	COG3038	cytochrome b561
TSH58p_29625	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TSH58p_29635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TSH58p_29645	COG1846	Transcriptional regulator
TSH58p_29655	COG3920	Histidine kinase
TSH58p_29670	COG1758	RNA polymerase activity
TSH58p_29685	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TSH58p_29690	COG0736	holo-[acyl-carrier-protein] synthase activity
TSH58p_29695	COG0681	Belongs to the peptidase S26 family
TSH58p_29700	COG0571	ribonuclease III activity
TSH58p_29705	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TSH58p_29710	COG3106	COG3106 Predicted ATPase
TSH58p_29715	COG3768	UPF0283 membrane protein
TSH58p_29735	COG0740	serine-type endopeptidase activity
TSH58p_29740	COG1215	transferase activity, transferring glycosyl groups
TSH58p_29745	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TSH58p_29750	COG1566	PFAM secretion protein HlyD family protein
TSH58p_29755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSH58p_29765	COG2308	Evidence 4 Homologs of previously reported genes of
TSH58p_29765	COG2307	Protein conserved in bacteria
TSH58p_29785	COG2017	converts alpha-aldose to the beta-anomer
TSH58p_29790	COG0515	serine threonine protein kinase
TSH58p_29790	COG2815	serine threonine protein kinase
TSH58p_29795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TSH58p_29825	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TSH58p_29835	COG0513	Belongs to the DEAD box helicase family
TSH58p_29860	COG0187	DNA topoisomerase II activity
TSH58p_29865	COG1607	acyl-coa hydrolase
TSH58p_29870	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TSH58p_29875	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TSH58p_29880	COG0022	dehydrogenase e1 component
TSH58p_29880	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSH58p_29885	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSH58p_29890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TSH58p_29895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TSH58p_29900	COG2867	negative regulation of translational initiation
TSH58p_29905	COG1546	Belongs to the CinA family
TSH58p_29905	COG1058	Belongs to the CinA family
TSH58p_29940	COG2204	response regulator
TSH58p_30090	COG0582	viral genome integration into host DNA
TSH58p_30200	COG1120	ATPase activity
TSH58p_30220	COG2271	Major facilitator Superfamily
TSH58p_30225	COG0583	DNA-binding transcription factor activity
TSH58p_30255	COG4774	siderophore transport
TSH58p_30260	COG1120	ATPase activity
TSH58p_30270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSH58p_30275	COG1132	(ABC) transporter
TSH58p_30285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_30325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TSH58p_30340	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TSH58p_30355	COG4263	nitrous-oxide reductase activity
TSH58p_30375	COG0714	Associated with various cellular activities
TSH58p_30380	COG3256	nitric oxide reductase
TSH58p_30390	COG2897	thiosulfate sulfurtransferase activity
TSH58p_30455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_30465	COG0446	pyridine nucleotide-disulphide oxidoreductase
TSH58p_30465	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TSH58p_30485	COG2072	flavoprotein involved in K transport
TSH58p_30490	COG2301	Belongs to the HpcH HpaI aldolase family
TSH58p_30500	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_30515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_30520	COG0022	dehydrogenase e1 component
TSH58p_30525	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TSH58p_30530	COG1396	sequence-specific DNA binding
TSH58p_30535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSH58p_30540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TSH58p_30550	COG0459	protein refolding
TSH58p_30555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TSH58p_30570	COG1464	Belongs to the NlpA lipoprotein family
TSH58p_30575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TSH58p_30580	COG2011	ABC-type metal ion transport system permease component
TSH58p_30590	COG1574	metal-dependent hydrolase with the TIM-barrel fold
TSH58p_30595	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_30600	COG1116	anion transmembrane transporter activity
TSH58p_30615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TSH58p_30640	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_30665	COG3842	ATPase activity
TSH58p_30670	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_30675	COG1177	transmembrane transport
TSH58p_30690	COG1917	Cupin 2, conserved barrel domain protein
TSH58p_30690	COG1396	sequence-specific DNA binding
TSH58p_30700	COG1335	isochorismatase
TSH58p_30705	COG0583	DNA-binding transcription factor activity
TSH58p_30710	COG1982	Orn Lys Arg decarboxylase major
TSH58p_30715	COG0697	spore germination
TSH58p_30720	COG4608	Belongs to the ABC transporter superfamily
TSH58p_30725	COG0444	Belongs to the ABC transporter superfamily
TSH58p_30730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_30735	COG0601	transmembrane transport
TSH58p_30745	COG0747	negative chemotaxis
TSH58p_30750	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSH58p_30755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TSH58p_30765	COG4608	Belongs to the ABC transporter superfamily
TSH58p_30770	COG0444	Belongs to the ABC transporter superfamily
TSH58p_30775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSH58p_30785	COG4948	Mandelate Racemase Muconate Lactonizing
TSH58p_30790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSH58p_30800	COG3181	Tripartite tricarboxylate transporter family receptor
TSH58p_30805	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSH58p_30845	COG0765	amino acid transport
TSH58p_30880	COG2175	clavaminate synthase activity
TSH58p_30885	COG1116	anion transmembrane transporter activity
TSH58p_30890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_30900	COG2175	clavaminate synthase activity
TSH58p_30910	COG4521	taurine ABC transporter
TSH58p_30915	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TSH58p_30920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_30925	COG3119	arylsulfatase activity
TSH58p_30930	COG2175	clavaminate synthase activity
TSH58p_30935	COG2084	Dehydrogenase
TSH58p_30945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_30950	COG3958	Transketolase
TSH58p_30955	COG3959	Transketolase, thiamine diphosphate binding domain
TSH58p_30960	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_30965	COG0583	DNA-binding transcription factor activity
TSH58p_30980	COG4772	TonB-dependent receptor
TSH58p_30995	COG2201	protein-glutamate methylesterase activity
TSH58p_31000	COG2205	protein histidine kinase activity
TSH58p_31000	COG5002	protein histidine kinase activity
TSH58p_31000	COG0784	Response regulator, receiver
TSH58p_31005	COG0747	negative chemotaxis
TSH58p_31015	COG1024	Enoyl-CoA hydratase
TSH58p_31020	COG1012	belongs to the aldehyde dehydrogenase family
TSH58p_31040	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_31045	COG1566	PFAM secretion protein HlyD family protein
TSH58p_31060	COG2207	Transcriptional regulator
TSH58p_31075	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_31085	COG3712	iron ion homeostasis
TSH58p_31110	COG0583	DNA-binding transcription factor activity
TSH58p_31120	COG0747	negative chemotaxis
TSH58p_31140	COG0251	oxidation-reduction process
TSH58p_31150	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSH58p_31170	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TSH58p_31200	COG3107	peptidoglycan biosynthetic process
TSH58p_31235	COG3920	Histidine kinase
TSH58p_31265	COG0318	PFAM AMP-dependent synthetase and ligase
TSH58p_31270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TSH58p_31295	COG0071	Belongs to the small heat shock protein (HSP20) family
TSH58p_31305	COG2249	NAD(P)H dehydrogenase (quinone) activity
TSH58p_31310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSH58p_31310	COG0574	Belongs to the PEP-utilizing enzyme family
TSH58p_31315	COG0577	efflux transmembrane transporter activity
TSH58p_31315	COG1136	(ABC) transporter
TSH58p_31320	COG0577	efflux transmembrane transporter activity
TSH58p_31320	COG1136	(ABC) transporter
TSH58p_31340	COG0667	Aldo Keto reductase
TSH58p_31350	COG1192	Involved in chromosome partitioning
TSH58p_31355	COG1475	DNA binding
TSH58p_31365	COG4626	Terminase
TSH58p_31365	COG1802	Transcriptional regulator
TSH58p_31395	COG4774	siderophore transport
TSH58p_31405	COG1595	DNA-templated transcription, initiation
TSH58p_31435	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSH58p_31445	COG1126	abc transporter atp-binding protein
TSH58p_31455	COG1070	Carbohydrate kinase
TSH58p_31460	COG2115	Belongs to the xylose isomerase family
TSH58p_31465	COG0673	inositol 2-dehydrogenase activity
TSH58p_31475	COG1879	ABC-type sugar transport system periplasmic component
TSH58p_31480	COG1172	Belongs to the binding-protein-dependent transport system permease family
TSH58p_31490	COG1940	carbohydrate kinase activity
TSH58p_31495	COG0251	oxidation-reduction process
TSH58p_31500	COG0583	DNA-binding transcription factor activity
TSH58p_31545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSH58p_31550	COG0402	S-adenosylhomocysteine deaminase activity
TSH58p_31565	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TSH58p_31575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_31585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSH58p_31590	COG1129	ABC transporter
TSH58p_31590	COG0842	Transport permease protein
TSH58p_31595	COG0842	Transport permease protein
TSH58p_31605	COG3721	Heme iron utilization protein
TSH58p_31615	COG0745	RESPONSE REGULATOR receiver
TSH58p_31620	COG1120	ATPase activity
TSH58p_31625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSH58p_31635	COG3720	iron ion transport
TSH58p_31640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TSH58p_31645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TSH58p_31660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_31670	COG0583	DNA-binding transcription factor activity
TSH58p_31680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TSH58p_31680	COG1017	nitric oxide dioxygenase activity
TSH58p_31685	COG0625	glutathione transferase activity
TSH58p_31690	COG1802	Transcriptional regulator
TSH58p_31695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
TSH58p_31700	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TSH58p_31705	COG1234	tRNA 3'-trailer cleavage
TSH58p_31710	COG1177	transmembrane transport
TSH58p_31725	COG3842	ATPase activity
TSH58p_31745	COG2197	response regulator
TSH58p_31750	COG0840	transmembrane signaling receptor activity
TSH58p_31760	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TSH58p_31765	COG3842	ATPase activity
TSH58p_31770	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_31775	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_31780	COG3938	Belongs to the proline racemase family
TSH58p_31785	COG1802	Transcriptional regulator
TSH58p_31790	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TSH58p_31795	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TSH58p_31800	COG0066	3-isopropylmalate dehydratase activity
TSH58p_31815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_31875	COG3842	ATPase activity
TSH58p_31880	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TSH58p_31885	COG1349	DNA-binding transcription factor activity
TSH58p_31900	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_31915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_31925	COG1024	Enoyl-CoA hydratase
TSH58p_31930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSH58p_31935	COG0154	amidase activity
TSH58p_31945	COG2188	Transcriptional regulator
TSH58p_32000	COG3316	Transposase and inactivated derivatives
TSH58p_32030	COG0714	Associated with various cellular activities
TSH58p_32065	COG2205	protein histidine kinase activity
TSH58p_32075	COG0784	Response regulator, receiver
TSH58p_32075	COG2205	protein histidine kinase activity
TSH58p_32100	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TSH58p_32130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TSH58p_32135	COG1454	alcohol dehydrogenase
TSH58p_32140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSH58p_32150	COG1116	anion transmembrane transporter activity
TSH58p_32155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSH58p_32165	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_32185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TSH58p_32190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSH58p_32195	COG0697	spore germination
TSH58p_32205	COG1609	Transcriptional regulator
TSH58p_32215	COG2188	Transcriptional regulator
TSH58p_32240	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
TSH58p_32290	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSH58p_32310	COG0861	Integral membrane protein TerC family
TSH58p_32315	COG0251	oxidation-reduction process
TSH58p_32325	COG0251	oxidation-reduction process
TSH58p_32330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSH58p_32350	COG1177	transmembrane transport
TSH58p_32355	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSH58p_32360	COG3842	ATPase activity
TSH58p_32380	COG0765	amino acid transport
TSH58p_32390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSH58p_32395	COG1304	FMN binding
TSH58p_32400	COG0277	FAD linked oxidase domain protein
TSH58p_32405	COG1396	sequence-specific DNA binding
TSH58p_32450	COG1028	Short-chain dehydrogenase reductase Sdr
TSH58p_32455	COG3246	L-lysine catabolic process to acetate
TSH58p_32460	COG1250	3-hydroxyacyl-CoA dehydrogenase
TSH58p_32465	COG2204	response regulator
TSH58p_32480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TSH58p_32485	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TSH58p_32490	COG1278	Cold shock
TSH58p_32500	COG4566	intracellular signal transduction
TSH58p_32500	COG0745	RESPONSE REGULATOR receiver
TSH58p_32515	COG0411	ABC transporter
TSH58p_32530	COG0683	leucine binding
TSH58p_32535	COG2814	Major facilitator Superfamily
TSH58p_32545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TSH58p_32550	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TSH58p_32580	COG0633	Ferredoxin
TSH58p_32585	COG2124	cytochrome p450
TSH58p_32600	COG0583	DNA-binding transcription factor activity
TSH58p_32610	COG1595	DNA-templated transcription, initiation
TSH58p_32615	COG4774	siderophore transport
TSH58p_32630	COG4774	siderophore transport