locus-tag	class	description
G8O30_00015	COG0735	belongs to the Fur family
G8O30_00060	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
G8O30_00070	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G8O30_00080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G8O30_00085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G8O30_00090	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G8O30_00095	COG0047	phosphoribosylformylglycinamidine synthase activity
G8O30_00100	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G8O30_00105	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G8O30_00110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G8O30_00115	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G8O30_00120	COG0138	bifunctional purine biosynthesis protein purh
G8O30_00125	COG0151	Belongs to the GarS family
G8O30_00135	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G8O30_00140	COG1470	cell adhesion involved in biofilm formation
G8O30_00145	COG4496	protein, YerC YecD
G8O30_00160	COG0210	DNA helicase
G8O30_00165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G8O30_00170	COG4851	CamS sex pheromone cAM373 precursor
G8O30_00175	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G8O30_00180	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G8O30_00185	COG0154	amidase activity
G8O30_00190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G8O30_00205	COG1597	lipid kinase activity
G8O30_00215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G8O30_00230	COG1595	DNA-templated transcription, initiation
G8O30_00235	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G8O30_00245	COG0318	PFAM AMP-dependent synthetase and ligase
G8O30_00260	COG2323	membrane
G8O30_00270	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G8O30_00275	COG1122	ATPase activity
G8O30_00280	COG4721	ABC-type cobalt transport system, permease component
G8O30_00340	COG2409	Drug exporters of the RND superfamily
G8O30_00365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G8O30_00370	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
G8O30_00380	COG1653	transport
G8O30_00400	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
G8O30_00405	COG1874	Beta-galactosidase
G8O30_00410	COG1609	Transcriptional regulator
G8O30_00435	COG1725	Transcriptional regulator
G8O30_00450	COG3655	Transcriptional regulator
G8O30_00455	COG3739	integral membrane protein
G8O30_00475	COG0840	transmembrane signaling receptor activity
G8O30_00510	COG0488	(ABC) transporter
G8O30_00565	COG3066	DNA modification
G8O30_00590	COG0693	protein deglycase activity
G8O30_00610	COG1361	Conserved repeat domain
G8O30_00645	COG1595	DNA-templated transcription, initiation
G8O30_00655	COG1131	(ABC) transporter
G8O30_00675	COG2249	NAD(P)H dehydrogenase (quinone) activity
G8O30_00720	COG0604	alcohol dehydrogenase
G8O30_00785	COG1309	transcriptional regulator
G8O30_00790	COG1131	(ABC) transporter
G8O30_00820	COG2217	Heavy metal translocating P-type atpase
G8O30_00830	COG1595	DNA-templated transcription, initiation
G8O30_00865	COG1349	DNA-binding transcription factor activity
G8O30_00870	COG0488	(ABC) transporter
G8O30_00880	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
G8O30_00890	COG2814	Major facilitator Superfamily
G8O30_00910	COG0673	inositol 2-dehydrogenase activity
G8O30_00915	COG1253	flavin adenine dinucleotide binding
G8O30_00945	COG0019	diaminopimelate decarboxylase activity
G8O30_00955	COG3711	transcriptional antiterminator
G8O30_00960	COG1263	PTS System
G8O30_00960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8O30_00960	COG2190	(PTS) system
G8O30_00970	COG2112	serine threonine protein kinase
G8O30_00975	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G8O30_00980	COG2770	Histidine kinase
G8O30_00980	COG3437	response regulator, receiver
G8O30_00985	COG3540	Alkaline phosphatase
G8O30_00990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G8O30_00995	COG0805	protein transport
G8O30_01010	COG4214	carbohydrate transport
G8O30_01025	COG2972	Histidine kinase
G8O30_01030	COG2207	Transcriptional regulator
G8O30_01030	COG4753	response regulator
G8O30_01035	COG4213	ABC transporter substrate-binding protein
G8O30_01040	COG0583	DNA-binding transcription factor activity
G8O30_01050	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
G8O30_01055	COG2814	Major facilitator Superfamily
G8O30_01100	COG1388	LysM domain
G8O30_01110	COG3852	Histidine kinase
G8O30_01115	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G8O30_01120	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
G8O30_01125	COG0351	phosphomethylpyrimidine kinase
G8O30_01130	COG0352	thiamine-phosphate diphosphorylase activity
G8O30_01135	COG2249	NAD(P)H dehydrogenase (quinone) activity
G8O30_01145	COG3012	SEC-C Motif Domain Protein
G8O30_01145	COG1405	negative regulation of cell septum assembly
G8O30_01150	COG2723	6-phospho-beta-galactosidase activity
G8O30_01160	COG1175	transmembrane transport
G8O30_01165	COG0395	ABC-type sugar transport system, permease component
G8O30_01170	COG1609	Transcriptional regulator
G8O30_01185	COG1011	Hydrolase
G8O30_01190	COG2199	diguanylate cyclase activity
G8O30_01190	COG2203	Gaf domain
G8O30_01205	COG3290	protein histidine kinase activity
G8O30_01210	COG3279	Response regulator of the LytR AlgR family
G8O30_01215	COG4555	ABC transporter
G8O30_01220	COG1668	transmembrane transport
G8O30_01230	COG2211	Major facilitator Superfamily
G8O30_01235	COG1301	dicarboxylic acid transport
G8O30_01245	COG1309	transcriptional regulator
G8O30_01250	COG1511	domain protein
G8O30_01260	COG1937	Protein conserved in bacteria
G8O30_01265	COG2210	Belongs to the sulfur carrier protein TusA family
G8O30_01270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G8O30_01270	COG0425	Belongs to the sulfur carrier protein TusA family
G8O30_01275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G8O30_01275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G8O30_01280	COG0425	Belongs to the sulfur carrier protein TusA family
G8O30_01285	COG0730	response to heat
G8O30_01290	COG1073	alpha beta
G8O30_01295	COG1028	Short-chain dehydrogenase reductase Sdr
G8O30_01300	COG5278	phosphoserine phosphatase activity
G8O30_01300	COG0840	transmembrane signaling receptor activity
G8O30_01325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8O30_01330	COG1733	regulation of RNA biosynthetic process
G8O30_01355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G8O30_01360	COG0166	Belongs to the GPI family
G8O30_01365	COG1744	ABC transporter substrate-binding protein PnrA-like
G8O30_01370	COG5002	protein histidine kinase activity
G8O30_01375	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G8O30_01380	COG0400	carboxylic ester hydrolase activity
G8O30_01385	COG0346	lactoylglutathione lyase activity
G8O30_01400	COG2966	Psort location CytoplasmicMembrane, score
G8O30_01405	COG3610	response to peptide
G8O30_01410	COG1132	(ABC) transporter
G8O30_01415	COG1132	(ABC) transporter
G8O30_01420	COG1227	inorganic diphosphatase activity
G8O30_01425	COG1764	response to oxidative stress
G8O30_01430	COG1846	Transcriptional regulator
G8O30_01445	COG4191	Histidine kinase
G8O30_01455	COG0488	(ABC) transporter
G8O30_01460	COG0702	epimerase
G8O30_01470	COG2244	polysaccharide biosynthetic process
G8O30_01495	COG4585	Histidine kinase
G8O30_01500	COG2197	response regulator
G8O30_01530	COG1585	Membrane protein implicated in regulation of membrane protease activity
G8O30_01535	COG2268	Band 7 protein
G8O30_01540	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
G8O30_01550	COG1077	Cell shape determining protein MreB Mrl
G8O30_01555	COG0840	transmembrane signaling receptor activity
G8O30_01560	COG1744	ABC transporter substrate-binding protein PnrA-like
G8O30_01565	COG2309	aminopeptidase activity
G8O30_01575	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G8O30_01580	COG1360	Flagellar Motor Protein
G8O30_01595	COG4980	gas vesicle protein
G8O30_01600	COG1295	ribonuclease BN
G8O30_01605	COG3275	phosphorelay sensor kinase activity
G8O30_01610	COG3279	Response regulator of the LytR AlgR family
G8O30_01615	COG1966	Carbon starvation protein
G8O30_01620	COG0477	Major facilitator Superfamily
G8O30_01640	COG0535	radical SAM domain protein
G8O30_01660	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
G8O30_01665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G8O30_01670	COG0598	Magnesium transport protein CorA
G8O30_01680	COG1090	epimerase
G8O30_01685	COG2137	regulation of response to DNA damage stimulus
G8O30_01690	COG4221	oxidoreductase activity
G8O30_01715	COG1988	membrane-bound metal-dependent
G8O30_01725	COG1194	a g-specific adenine glycosylase
G8O30_01735	COG1028	Short-chain dehydrogenase reductase Sdr
G8O30_01760	COG1132	(ABC) transporter
G8O30_01765	COG0444	Belongs to the ABC transporter superfamily
G8O30_01770	COG4608	Belongs to the ABC transporter superfamily
G8O30_01775	COG0747	negative chemotaxis
G8O30_01780	COG0601	transmembrane transport
G8O30_01785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G8O30_01790	COG4129	membrane
G8O30_01805	COG4555	ABC transporter
G8O30_01825	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G8O30_01840	COG0735	belongs to the Fur family
G8O30_01960	COG2972	Histidine kinase
G8O30_01965	COG4753	response regulator
G8O30_01965	COG2207	Transcriptional regulator
G8O30_01975	COG0673	inositol 2-dehydrogenase activity
G8O30_01980	COG0673	inositol 2-dehydrogenase activity
G8O30_01995	COG3594	Acyltransferase
G8O30_02005	COG3382	B3 4 domain protein
G8O30_02010	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G8O30_02020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G8O30_02030	COG2766	serine protein kinase
G8O30_02040	COG2718	Belongs to the UPF0229 family
G8O30_02055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G8O30_02060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8O30_02065	COG1120	ATPase activity
G8O30_02075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G8O30_02090	COG2252	PERMEase
G8O30_02095	COG0778	Nitroreductase
G8O30_02100	COG1970	mechanosensitive ion channel activity
G8O30_02105	COG3973	AAA domain
G8O30_02115	COG0656	L-ascorbic acid biosynthetic process
G8O30_02120	COG0655	NAD(P)H dehydrogenase (quinone) activity
G8O30_02125	COG0564	pseudouridine synthase activity
G8O30_02140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G8O30_02145	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G8O30_02150	COG0366	Alpha amylase catalytic
G8O30_02160	COG1309	transcriptional regulator
G8O30_02165	COG3153	acetyltransferase
G8O30_02165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G8O30_02170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8O30_02175	COG4585	Histidine kinase
G8O30_02175	COG2203	Gaf domain
G8O30_02180	COG2197	response regulator
G8O30_02185	COG0431	NADPH-dependent FMN reductase
G8O30_02200	COG0456	acetyltransferase
G8O30_02205	COG2719	SpoVR family
G8O30_02265	COG0561	phosphatase activity
G8O30_02295	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
G8O30_02310	COG0456	acetyltransferase
G8O30_02325	COG1078	dGTPase activity
G8O30_02370	COG0018	arginyl-trna synthetase
G8O30_02380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G8O30_02400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G8O30_02415	COG3708	Transcriptional regulator
G8O30_02415	COG2207	Transcriptional regulator
G8O30_02425	COG1247	-acetyltransferase
G8O30_02430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G8O30_02455	COG2259	Doxx family
G8O30_02535	COG3340	Belongs to the peptidase S51 family
G8O30_02540	COG0640	Transcriptional regulator
G8O30_02575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G8O30_02580	COG0640	Transcriptional regulator
G8O30_02585	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G8O30_02605	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G8O30_02610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
G8O30_02620	COG2610	gluconate transmembrane transporter activity
G8O30_02625	COG2610	gluconate transmembrane transporter activity
G8O30_02635	COG4589	Belongs to the CDS family
G8O30_02645	COG1272	protein, Hemolysin III
G8O30_02660	COG0110	maltose O-acetyltransferase activity
G8O30_02665	COG2322	membrane
G8O30_02670	COG2814	Major facilitator Superfamily
G8O30_02675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G8O30_02675	COG0551	DNA topoisomerase type I activity
G8O30_02680	COG0456	acetyltransferase
G8O30_02695	COG2205	protein histidine kinase activity
G8O30_02710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8O30_02715	COG0011	TIGRFAM Protein of
G8O30_02720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8O30_02725	COG1116	anion transmembrane transporter activity
G8O30_02735	COG1533	DNA photolyase activity
G8O30_02740	COG1301	dicarboxylic acid transport
G8O30_02745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G8O30_02750	COG0415	Belongs to the DNA photolyase family
G8O30_02760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8O30_02765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G8O30_02770	COG1132	(ABC) transporter
G8O30_02775	COG1132	(ABC) transporter
G8O30_02780	COG0702	epimerase
G8O30_02785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8O30_02790	COG0765	amino acid transport
G8O30_02795	COG1126	abc transporter atp-binding protein
G8O30_02810	COG0840	transmembrane signaling receptor activity
G8O30_02815	COG1181	Belongs to the D-alanine--D-alanine ligase family
G8O30_02820	COG3842	ATPase activity
G8O30_02825	COG2508	Transcriptional regulator
G8O30_02850	COG0189	ligase activity
G8O30_02865	COG4399	Belongs to the UPF0754 family
G8O30_02875	COG0561	phosphatase activity
G8O30_02880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G8O30_02885	COG1024	Enoyl-CoA hydratase
G8O30_02895	COG4152	abc transporter atp-binding protein
G8O30_02900	COG1668	transmembrane transport
G8O30_02905	COG0420	3'-5' exonuclease activity
G8O30_02920	COG2814	Major facilitator Superfamily
G8O30_02925	COG3481	metal-dependent phosphohydrolase, HD sub domain
G8O30_02935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G8O30_02970	COG1846	Transcriptional regulator
G8O30_02985	COG2153	protein acetylation
G8O30_02990	COG2356	endonuclease I
G8O30_03000	COG0537	adenosine 5'-monophosphoramidase activity
G8O30_03005	COG1131	(ABC) transporter
G8O30_03010	COG4473	ABC transporter
G8O30_03020	COG1473	amidohydrolase
G8O30_03025	COG3069	C4-dicarboxylate transmembrane transporter activity
G8O30_03030	COG1335	isochorismatase
G8O30_03035	COG3403	YqcI/YcgG family
G8O30_03040	COG1280	lysine exporter protein (LysE YggA)
G8O30_03045	COG1115	amino acid carrier protein
G8O30_03050	COG2329	Antibiotic biosynthesis monooxygenase
G8O30_03055	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G8O30_03060	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G8O30_03065	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
G8O30_03070	COG1999	signal sequence binding
G8O30_03080	COG1234	tRNA 3'-trailer cleavage
G8O30_03085	COG0095	Lipoate-protein ligase
G8O30_03090	COG0318	PFAM AMP-dependent synthetase and ligase
G8O30_03095	COG1024	Enoyl-CoA hydratase
G8O30_03100	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
G8O30_03110	COG0501	Belongs to the peptidase M48B family
G8O30_03130	COG0398	Pfam SNARE associated Golgi protein
G8O30_03150	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
G8O30_03155	COG1074	ATP-dependent DNA helicase activity
G8O30_03160	COG1403	HNH endonuclease
G8O30_03205	COG3300	MHYT domain
G8O30_03205	COG5001	Diguanylate cyclase
G8O30_03215	COG0367	asparagine synthase
G8O30_03230	COG1562	ergosterol biosynthetic process
G8O30_03235	COG0004	ammonium transporteR
G8O30_03240	COG0347	Belongs to the P(II) protein family
G8O30_03245	COG0534	Mate efflux family protein
G8O30_03255	COG2182	Extracellular solute-binding protein
G8O30_03260	COG1175	transmembrane transport
G8O30_03265	COG3833	ABC-type maltose transport systems, permease component
G8O30_03270	COG1874	Beta-galactosidase
G8O30_03270	COG0366	Alpha amylase catalytic
G8O30_03275	COG1609	Transcriptional regulator
G8O30_03280	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8O30_03290	COG1307	EDD domain protein, DegV family
G8O30_03295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8O30_03310	COG0561	phosphatase activity
G8O30_03315	COG2151	metal-sulfur cluster biosynthetic enzyme
G8O30_03335	COG2267	carboxylic ester hydrolase activity
G8O30_03345	COG1744	ABC transporter substrate-binding protein PnrA-like
G8O30_03355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G8O30_03360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G8O30_03365	COG5504	Zn-dependent protease
G8O30_03370	COG0444	Belongs to the ABC transporter superfamily
G8O30_03375	COG4608	Belongs to the ABC transporter superfamily
G8O30_03385	COG0601	transmembrane transport
G8O30_03390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G8O30_03400	COG0180	Tryptophanyl-tRNA synthetase
G8O30_03415	COG0601	transmembrane transport
G8O30_03420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G8O30_03425	COG0444	Belongs to the ABC transporter superfamily
G8O30_03430	COG4608	Belongs to the ABC transporter superfamily
G8O30_03435	COG0456	acetyltransferase
G8O30_03440	COG1393	Belongs to the ArsC family
G8O30_03445	COG4862	establishment of competence for transformation
G8O30_03450	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8O30_03460	COG1164	Oligoendopeptidase f
G8O30_03465	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G8O30_03470	COG2346	COG2346, Truncated hemoglobins
G8O30_03475	COG0741	lytic transglycosylase activity
G8O30_03490	COG2357	RelA SpoT domain protein
G8O30_03500	COG0564	pseudouridine synthase activity
G8O30_03510	COG2239	Acts as a magnesium transporter
G8O30_03555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G8O30_03590	COG2382	esterase
G8O30_03595	COG2358	TRAP transporter, solute receptor (TAXI family
G8O30_03615	COG0673	inositol 2-dehydrogenase activity
G8O30_03620	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G8O30_03625	COG3844	kynureninase activity
G8O30_03640	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8O30_03650	COG2199	diguanylate cyclase activity
G8O30_03655	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G8O30_03670	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G8O30_03675	COG1757	Na H antiporter
G8O30_03690	COG0861	Integral membrane protein TerC family
G8O30_03695	COG1191	sigma factor activity
G8O30_03710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G8O30_03730	COG5002	protein histidine kinase activity
G8O30_03735	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G8O30_03740	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
G8O30_03745	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
G8O30_03750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G8O30_03755	COG0436	Aminotransferase
G8O30_03760	COG1850	ribulose-bisphosphate carboxylase activity
G8O30_03765	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
G8O30_03770	COG0235	Class ii aldolase
G8O30_03775	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
G8O30_03795	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G8O30_03800	COG3639	organic phosphonate transmembrane transporter activity
G8O30_03805	COG3639	organic phosphonate transmembrane transporter activity
G8O30_03810	COG0737	Belongs to the 5'-nucleotidase family
G8O30_03815	COG1846	Transcriptional regulator
G8O30_03825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G8O30_03830	COG3949	Membrane
G8O30_03850	COG4873	Protein conserved in bacteria
G8O30_03880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G8O30_03900	COG0436	Aminotransferase
G8O30_03905	COG1714	RDD family
G8O30_03920	COG0784	Response regulator, receiver
G8O30_03920	COG0835	chemotaxis
G8O30_03930	COG0248	Ppx GppA phosphatase
G8O30_03935	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G8O30_03945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G8O30_03950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G8O30_03955	COG5001	Diguanylate cyclase
G8O30_03955	COG3300	MHYT domain
G8O30_03960	COG1408	metallophosphoesterase
G8O30_03970	COG1028	Short-chain dehydrogenase reductase Sdr
G8O30_03975	COG2200	EAL domain
G8O30_03995	COG4703	Protein of unknown function (DUF1797)
G8O30_04000	COG0477	Major facilitator Superfamily
G8O30_04005	COG0583	DNA-binding transcription factor activity
G8O30_04010	COG2171	N-acyltransferase activity
G8O30_04015	COG1473	amidohydrolase
G8O30_04020	COG0668	transmembrane transport
G8O30_04025	COG1132	(ABC) transporter
G8O30_04030	COG1132	(ABC) transporter
G8O30_04035	COG0569	domain protein
G8O30_04040	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G8O30_04045	COG5503	Protein of unknown function (DUF1447)
G8O30_04050	COG0561	phosphatase activity
G8O30_04055	COG0242	peptide deformylase activity
G8O30_04070	COG0022	dehydrogenase e1 component
G8O30_04090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G8O30_04100	COG1982	Orn Lys Arg decarboxylase major
G8O30_04120	COG4493	Belongs to the UPF0637 family
G8O30_04130	COG0483	inositol monophosphate 1-phosphatase activity
G8O30_04140	COG1217	gtp-binding protein TYPA
G8O30_04155	COG4896	Protein conserved in bacteria
G8O30_04170	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G8O30_04175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G8O30_04180	COG2066	Belongs to the glutaminase family
G8O30_04185	COG4838	Belongs to the UPF0358 family
G8O30_04190	COG0772	Belongs to the SEDS family
G8O30_04195	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G8O30_04200	COG1612	heme a metabolic process
G8O30_04220	COG1845	cytochrome c oxidase, subunit III
G8O30_04230	COG3336	cytochrome c oxidase
G8O30_04240	COG0628	permease
G8O30_04255	COG2340	Cysteine-rich secretory protein family
G8O30_04280	COG3679	Belongs to the UPF0342 family
G8O30_04285	COG4471	UPF0298 protein
G8O30_04300	COG0742	ribosomal rna small subunit methyltransferase
G8O30_04305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G8O30_04310	COG3314	Sporulation integral membrane protein YlbJ
G8O30_04315	COG1752	Esterase of the alpha-beta hydrolase superfamily
G8O30_04320	COG3480	Lon protease (S16) C-terminal proteolytic domain
G8O30_04325	COG1323	Belongs to the UPF0348 family
G8O30_04330	COG1399	metal-binding, possibly nucleic acid-binding protein
G8O30_04340	COG1024	Enoyl-CoA hydratase
G8O30_04350	COG0454	-acetyltransferase
G8O30_04355	COG0439	Biotin carboxylase
G8O30_04360	COG0511	ligase activity, forming carbon-carbon bonds
G8O30_04365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G8O30_04370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G8O30_04385	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
G8O30_04395	COG0275	rRNA processing
G8O30_04405	COG0768	penicillin binding
G8O30_04410	COG0768	penicillin binding
G8O30_04415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G8O30_04425	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G8O30_04430	COG0772	Belongs to the SEDS family
G8O30_04440	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G8O30_04445	COG3879	Bacterial protein of unknown function (DUF881)
G8O30_04450	COG3879	Bacterial protein of unknown function (DUF881)
G8O30_04455	COG3856	small basic protein
G8O30_04460	COG0849	cell division
G8O30_04465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G8O30_04475	COG1191	sigma factor activity
G8O30_04480	COG1191	sigma factor activity
G8O30_04490	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G8O30_04495	COG1799	cell septum assembly
G8O30_04500	COG0762	integral membrane protein
G8O30_04505	COG2302	S4 RNA-binding domain
G8O30_04510	COG3599	regulation of cell shape
G8O30_04515	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G8O30_04520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G8O30_04525	COG0564	pseudouridine synthase activity
G8O30_04530	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G8O30_04540	COG0540	Belongs to the ATCase OTCase family
G8O30_04550	COG0505	Belongs to the CarA family
G8O30_04560	COG0543	2 iron, 2 sulfur cluster binding
G8O30_04565	COG0167	dihydroorotate dehydrogenase activity
G8O30_04575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G8O30_04590	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G8O30_04595	COG1561	YicC-like family, N-terminal region
G8O30_04600	COG2052	Domain of unknown function (DUF370)
G8O30_04605	COG0194	GDP metabolic process
G8O30_04615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G8O30_04635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G8O30_04635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G8O30_04640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G8O30_04645	COG0631	protein serine/threonine phosphatase activity
G8O30_04650	COG2815	serine threonine protein kinase
G8O30_04650	COG0515	serine threonine protein kinase
G8O30_04655	COG1162	GTPase activity
G8O30_04660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G8O30_04665	COG1564	THIamine pyrophosphokinase
G8O30_04675	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G8O30_04680	COG1302	Protein conserved in bacteria
G8O30_04685	COG1461	Dihydroxyacetone kinase
G8O30_04690	COG1760	l-serine dehydratase
G8O30_04695	COG1760	l-serine dehydratase
G8O30_04700	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G8O30_04705	COG1349	DNA-binding transcription factor activity
G8O30_04710	COG0416	fatty acid biosynthetic process
G8O30_04715	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G8O30_04720	COG1028	Short-chain dehydrogenase reductase Sdr
G8O30_04730	COG0571	ribonuclease III activity
G8O30_04735	COG1196	nuclear chromosome segregation
G8O30_04740	COG0552	protein localization to endoplasmic reticulum
G8O30_04745	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
G8O30_04750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G8O30_04760	COG1837	Belongs to the UPF0109 family
G8O30_04770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G8O30_04780	COG0335	large ribosomal subunit rRNA binding
G8O30_04795	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G8O30_04805	COG2257	FlhB HrpN YscU SpaS Family
G8O30_04815	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G8O30_04820	COG0758	DNA mediated transformation
G8O30_04825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G8O30_04830	COG4974	Belongs to the 'phage' integrase family
G8O30_04835	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G8O30_04845	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
G8O30_04850	COG1815	bacterial-type flagellum-dependent cell motility
G8O30_04855	COG1558	bacterial-type flagellum-dependent cell motility
G8O30_04860	COG1677	Flagellar hook-basal body complex protein FliE
G8O30_04865	COG1766	The M ring may be actively involved in energy transduction
G8O30_04870	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G8O30_04875	COG1317	bacterial-type flagellum organization
G8O30_04880	COG1157	protein secretion by the type III secretion system
G8O30_04900	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G8O30_04915	COG1582	Flagellar protein (FlbD)
G8O30_04920	COG1580	Controls the rotational direction of flagella during chemotaxis
G8O30_04925	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G8O30_04930	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G8O30_04930	COG1776	CheC inhibitor of MCP methylation
G8O30_04935	COG2201	protein-glutamate methylesterase activity
G8O30_04940	COG3190	flagellar
G8O30_04945	COG1338	Plays a role in the flagellum-specific transport system
G8O30_04950	COG1987	bacterial-type flagellum assembly
G8O30_04955	COG1684	flagellar biosynthetic protein fliR
G8O30_04960	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G8O30_04965	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G8O30_04970	COG1419	protein localization to endoplasmic reticulum
G8O30_04975	COG0455	bacterial-type flagellum organization
G8O30_04980	COG2201	protein-glutamate methylesterase activity
G8O30_04985	COG2198	Histidine kinase
G8O30_04985	COG0643	Histidine kinase
G8O30_04990	COG0835	chemotaxis
G8O30_04995	COG1776	CheC inhibitor of MCP methylation
G8O30_05000	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G8O30_05010	COG1191	sigma factor activity
G8O30_05025	COG0052	Belongs to the universal ribosomal protein uS2 family
G8O30_05040	COG0233	cytoplasmic translational termination
G8O30_05045	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G8O30_05050	COG4589	Belongs to the CDS family
G8O30_05060	COG0750	zinc metalloprotease
G8O30_05065	COG0442	prolyl-tRNA aminoacylation
G8O30_05070	COG2176	DNA-directed DNA polymerase activity
G8O30_05080	COG0195	Participates in both transcription termination and antitermination
G8O30_05085	COG2740	Nucleic-acid-binding protein implicated in transcription termination
G8O30_05090	COG1358	cellular component organization or biogenesis
G8O30_05100	COG1550	Protein conserved in bacteria
G8O30_05105	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G8O30_05110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G8O30_05115	COG0196	riboflavin kinase activity
G8O30_05120	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G8O30_05125	COG1185	polyribonucleotide nucleotidyltransferase activity
G8O30_05130	COG0726	polysaccharide deacetylase
G8O30_05135	COG0612	Peptidase, M16
G8O30_05140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8O30_05145	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G8O30_05150	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G8O30_05165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G8O30_05170	COG0740	serine-type endopeptidase activity
G8O30_05180	COG4980	gas vesicle protein
G8O30_05180	COG1674	ftsk spoiiie
G8O30_05190	COG1744	ABC transporter substrate-binding protein PnrA-like
G8O30_05195	COG3845	ABC transporter
G8O30_05200	COG4603	Belongs to the binding-protein-dependent transport system permease family
G8O30_05205	COG1079	Belongs to the binding-protein-dependent transport system permease family
G8O30_05210	COG0612	Peptidase, M16
G8O30_05215	COG0612	Peptidase, M16
G8O30_05235	COG1426	Protein conserved in bacteria
G8O30_05240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G8O30_05250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G8O30_05255	COG1418	mRNA catabolic process
G8O30_05260	COG1692	metallophosphoesterase
G8O30_05265	COG2359	stage V sporulation protein S
G8O30_05275	COG0674	pyruvate-flavodoxin oxidoreductase activity
G8O30_05275	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
G8O30_05280	COG1013	pyruvate-flavodoxin oxidoreductase activity
G8O30_05285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G8O30_05290	COG4550	Control of competence regulator ComK, YlbF/YmcA
G8O30_05305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G8O30_05310	COG0083	homoserine kinase activity
G8O30_05325	COG2205	protein histidine kinase activity
G8O30_05340	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G8O30_05345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G8O30_05355	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G8O30_05365	COG0464	growth
G8O30_05375	COG3011	Protein conserved in bacteria
G8O30_05380	COG2860	membrane
G8O30_05385	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G8O30_05390	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
G8O30_05395	COG0789	Transcriptional regulator
G8O30_05400	COG0174	glutamine synthetase
G8O30_05405	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G8O30_05415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G8O30_05420	COG4224	UPF0291 protein
G8O30_05445	COG0785	Cytochrome C biogenesis protein
G8O30_05450	COG2201	protein-glutamate methylesterase activity
G8O30_05455	COG4846	Membrane protein involved in cytochrome C biogenesis
G8O30_05485	COG0420	3'-5' exonuclease activity
G8O30_05490	COG0419	ATPase involved in DNA repair
G8O30_05500	COG2364	Membrane
G8O30_05505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G8O30_05530	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G8O30_05535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G8O30_05555	COG0824	Thioesterase
G8O30_05575	COG0745	RESPONSE REGULATOR receiver
G8O30_05580	COG5002	protein histidine kinase activity
G8O30_05595	COG3279	Response regulator of the LytR AlgR family
G8O30_05600	COG2205	protein histidine kinase activity
G8O30_05600	COG0784	Response regulator, receiver
G8O30_05605	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G8O30_05610	COG1388	LysM domain
G8O30_05610	COG3858	chitin binding
G8O30_05615	COG1125	glycine betaine transport
G8O30_05615	COG0517	IMP dehydrogenase activity
G8O30_05620	COG1174	glycine betaine transport
G8O30_05625	COG1732	Glycine betaine
G8O30_05635	COG0523	cobalamin synthesis protein
G8O30_05640	COG1832	CoA-binding protein
G8O30_05645	COG0187	DNA topoisomerase II activity
G8O30_05650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G8O30_05655	COG1115	amino acid carrier protein
G8O30_05675	COG2323	membrane
G8O30_05685	COG0702	epimerase
G8O30_05695	COG3773	Cell wall hydrolase
G8O30_05715	COG3409	Peptidoglycan-binding domain 1 protein
G8O30_05715	COG3773	Cell wall hydrolase
G8O30_05720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G8O30_05745	COG0494	nUDIX hydrolase
G8O30_05775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
G8O30_05780	COG1268	BioY protein
G8O30_05795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G8O30_05800	COG0601	transmembrane transport
G8O30_05805	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G8O30_05810	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G8O30_05815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G8O30_05850	COG5522	Integral membrane protein (intg_mem_TP0381)
G8O30_05860	COG1785	Belongs to the alkaline phosphatase family
G8O30_05865	COG0693	protein deglycase activity
G8O30_05880	COG0254	rRNA binding
G8O30_05885	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G8O30_05905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8O30_05920	COG1131	(ABC) transporter
G8O30_05925	COG1725	Transcriptional regulator
G8O30_05930	COG1028	Short-chain dehydrogenase reductase Sdr
G8O30_05940	COG0463	Glycosyl transferase, family 2
G8O30_05945	COG2996	Protein conserved in bacteria
G8O30_05960	COG2814	Major facilitator Superfamily
G8O30_05965	COG0514	ATP-dependent DNA helicase (RecQ)
G8O30_05970	COG0488	(ABC) transporter
G8O30_06005	COG0814	amino acid
G8O30_06020	COG3853	Toxic anion resistance protein (TelA)
G8O30_06025	COG0840	transmembrane signaling receptor activity
G8O30_06035	COG4548	von Willebrand factor, type A
G8O30_06040	COG0714	Associated with various cellular activities
G8O30_06065	COG2746	aminoglycoside 3-N-acetyltransferase activity
G8O30_06075	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8O30_06080	COG0567	Dehydrogenase, E1 component
G8O30_06090	COG5002	protein histidine kinase activity
G8O30_06110	COG0701	Predicted permease
G8O30_06130	COG0133	tryptophan synthase activity
G8O30_06135	COG0135	phosphoribosylanthranilate isomerase activity
G8O30_06140	COG0134	indole-3-glycerol-phosphate synthase activity
G8O30_06145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G8O30_06150	COG0512	Glutamine amidotransferase of anthranilate synthase
G8O30_06150	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G8O30_06170	COG1278	Cold shock
G8O30_06180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G8O30_06190	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
G8O30_06200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G8O30_06205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G8O30_06205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G8O30_06210	COG0307	riboflavin synthase, alpha
G8O30_06215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G8O30_06215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G8O30_06235	COG1752	Esterase of the alpha-beta hydrolase superfamily
G8O30_06245	COG0586	Pfam SNARE associated Golgi protein
G8O30_06250	COG0402	S-adenosylhomocysteine deaminase activity
G8O30_06260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G8O30_06275	COG1215	transferase activity, transferring glycosyl groups
G8O30_06290	COG0534	Mate efflux family protein
G8O30_06295	COG1028	Short-chain dehydrogenase reductase Sdr
G8O30_06325	COG3409	Peptidoglycan-binding domain 1 protein
G8O30_06325	COG0793	Belongs to the peptidase S41A family
G8O30_06330	COG1876	peptidase activity
G8O30_06335	COG0813	purine-nucleoside phosphorylase activity
G8O30_06350	COG4326	sporulation control protein
G8O30_06365	COG4479	Belongs to the UPF0346 family
G8O30_06370	COG0840	transmembrane signaling receptor activity
G8O30_06370	COG5278	phosphoserine phosphatase activity
G8O30_06380	COG2190	(PTS) system
G8O30_06385	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8O30_06415	COG1307	EDD domain protein, DegV family
G8O30_06430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G8O30_06435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G8O30_06455	COG2521	methyltransferase
G8O30_06455	COG2136	Putative SAM-dependent methyltransferase
G8O30_06465	COG1413	lyase activity
G8O30_06470	COG0488	(ABC) transporter
G8O30_06475	COG1418	mRNA catabolic process
G8O30_06480	COG2759	Belongs to the formate--tetrahydrofolate ligase family
G8O30_06490	COG1988	membrane-bound metal-dependent
G8O30_06500	COG1321	iron dependent repressor
G8O30_06505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G8O30_06510	COG1321	iron dependent repressor
G8O30_06510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G8O30_06515	COG1121	(ABC) transporter
G8O30_06520	COG0803	Belongs to the bacterial solute-binding protein 9 family
G8O30_06525	COG1278	Cold shock
G8O30_06540	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
G8O30_06555	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
G8O30_06560	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G8O30_06565	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
G8O30_06570	COG1755	Isoprenylcysteine carboxyl methyltransferase
G8O30_06575	COG3424	synthase
G8O30_06585	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
G8O30_06590	COG1199	ATP-dependent helicase activity
G8O30_06600	COG0116	Belongs to the methyltransferase superfamily
G8O30_06610	COG3599	regulation of cell shape
G8O30_06615	COG4474	Belongs to the UPF0398 family
G8O30_06625	COG3359	exonuclease
G8O30_06630	COG1111	helicase
G8O30_06630	COG1205	dead DEAH box helicase
G8O30_06635	COG0071	Belongs to the small heat shock protein (HSP20) family
G8O30_06665	COG3331	DNA recombination
G8O30_06670	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8O30_06670	COG4499	WXG100 protein secretion system (Wss), protein YukC
G8O30_06680	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G8O30_06685	COG3935	DnaD domain protein
G8O30_06690	COG0017	Asparaginyl-tRNA synthetase
G8O30_06710	COG1199	ATP-dependent helicase activity
G8O30_06710	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G8O30_06715	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G8O30_06720	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G8O30_06730	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G8O30_06730	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G8O30_06740	COG0438	transferase activity, transferring glycosyl groups
G8O30_06745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G8O30_06755	COG1694	Mazg nucleotide pyrophosphohydrolase
G8O30_06760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8O30_06765	COG2738	Putative neutral zinc metallopeptidase
G8O30_06775	COG4347	Protein of unknown function (DUF1405)
G8O30_06780	COG0840	transmembrane signaling receptor activity
G8O30_06790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G8O30_06805	COG5582	Belongs to the UPF0302 family
G8O30_06810	COG0457	Tetratricopeptide repeat
G8O30_06820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G8O30_06825	COG0287	Prephenate dehydrogenase
G8O30_06835	COG4401	Chorismate mutase type I
G8O30_06845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G8O30_06850	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G8O30_06855	COG0105	UTP biosynthetic process
G8O30_06860	COG0142	geranyltranstransferase activity
G8O30_06865	COG2226	methyltransferase
G8O30_06870	COG0142	geranyltranstransferase activity
G8O30_06885	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
G8O30_06925	COG1304	FMN binding
G8O30_06930	COG0539	negative regulation of cytoplasmic translation
G8O30_06940	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G8O30_06955	COG2959	enzyme of heme biosynthesis
G8O30_06960	COG3409	Peptidoglycan-binding domain 1 protein
G8O30_06960	COG3773	Cell wall hydrolase
G8O30_06965	COG2339	peptidase activity
G8O30_06975	COG0492	ferredoxin-NADP+ reductase activity
G8O30_06980	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G8O30_06985	COG4862	establishment of competence for transformation
G8O30_06990	COG0789	Transcriptional regulator
G8O30_06995	COG1408	metallophosphoesterase
G8O30_07015	COG0514	ATP-dependent DNA helicase (RecQ)
G8O30_07020	COG4955	Helix-turn-helix domain
G8O30_07025	COG1141	Ferredoxin
G8O30_07030	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
G8O30_07040	COG1595	DNA-templated transcription, initiation
G8O30_07045	COG5002	protein histidine kinase activity
G8O30_07050	COG0745	RESPONSE REGULATOR receiver
G8O30_07055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G8O30_07060	COG1333	cytochrome c biogenesis protein
G8O30_07065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G8O30_07070	COG1187	pseudouridine synthase activity
G8O30_07075	COG0700	Nucleoside recognition
G8O30_07080	COG2715	membrane protein required for spore maturation
G8O30_07085	COG1686	Belongs to the peptidase S11 family
G8O30_07090	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G8O30_07100	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G8O30_07115	COG1547	Domain of unknown function (DUF309)
G8O30_07130	COG0697	spore germination
G8O30_07150	COG1028	Short-chain dehydrogenase reductase Sdr
G8O30_07155	COG2610	gluconate transmembrane transporter activity
G8O30_07165	COG2172	sigma factor antagonist activity
G8O30_07170	COG1366	Belongs to the anti-sigma-factor antagonist family
G8O30_07175	COG1686	Belongs to the peptidase S11 family
G8O30_07195	COG4974	Belongs to the 'phage' integrase family
G8O30_07205	COG0735	belongs to the Fur family
G8O30_07210	COG1300	Membrane
G8O30_07215	COG0494	nUDIX hydrolase
G8O30_07220	COG0667	Aldo Keto reductase
G8O30_07230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G8O30_07235	COG1073	alpha beta
G8O30_07240	COG4918	Iron-sulphur cluster biosynthesis
G8O30_07260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G8O30_07285	COG0300	oxidoreductase activity
G8O30_07290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G8O30_07295	COG1902	pentaerythritol trinitrate reductase activity
G8O30_07320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G8O30_07325	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G8O30_07330	COG5506	Protein of unknown function (DUF1694)
G8O30_07335	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G8O30_07350	COG2195	Cleaves the N-terminal amino acid of tripeptides
G8O30_07360	COG0346	lactoylglutathione lyase activity
G8O30_07370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8O30_07380	COG1376	ErfK ybiS ycfS ynhG family protein
G8O30_07385	COG4129	membrane
G8O30_07390	COG1126	abc transporter atp-binding protein
G8O30_07395	COG0765	amino acid transport
G8O30_07400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8O30_07425	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8O30_07430	COG0022	dehydrogenase e1 component
G8O30_07435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
G8O30_07440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8O30_07445	COG3426	butyrate kinase activity
G8O30_07455	COG0280	phosphate acetyltransferase
G8O30_07460	COG3829	transcription factor binding
G8O30_07460	COG3290	protein histidine kinase activity
G8O30_07470	COG0584	glycerophosphoryl diester phosphodiesterase
G8O30_07485	COG0745	RESPONSE REGULATOR receiver
G8O30_07490	COG0750	zinc metalloprotease
G8O30_07495	COG0497	DNA recombination
G8O30_07505	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
G8O30_07515	COG0142	geranyltranstransferase activity
G8O30_07525	COG1570	exodeoxyribonuclease VII activity
G8O30_07545	COG1302	Protein conserved in bacteria
G8O30_07550	COG0439	Biotin carboxylase
G8O30_07555	COG0511	ligase activity, forming carbon-carbon bonds
G8O30_07595	COG3854	ATPases associated with a variety of cellular activities
G8O30_07600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G8O30_07605	COG0006	proline dipeptidase activity
G8O30_07610	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G8O30_07620	COG3872	metal-dependent enzyme
G8O30_07640	COG1752	Esterase of the alpha-beta hydrolase superfamily
G8O30_07645	COG2205	protein histidine kinase activity
G8O30_07650	COG0745	RESPONSE REGULATOR receiver
G8O30_07660	COG1136	(ABC) transporter
G8O30_07665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G8O30_07670	COG0095	Lipoate-protein ligase
G8O30_07675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G8O30_07680	COG2843	Capsule synthesis protein
G8O30_07685	COG2843	Capsule synthesis protein
G8O30_07690	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G8O30_07695	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G8O30_07700	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G8O30_07705	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G8O30_07730	COG4940	Competence protein ComGF
G8O30_07740	COG4537	Required for transformation and DNA binding
G8O30_07745	COG1459	type II secretion system
G8O30_07750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G8O30_07760	COG1393	Belongs to the ArsC family
G8O30_07770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G8O30_07780	COG0011	TIGRFAM Protein of
G8O30_07800	COG1368	sulfuric ester hydrolase activity
G8O30_07805	COG1940	carbohydrate kinase activity
G8O30_07810	COG4483	Protein conserved in bacteria
G8O30_07815	COG0697	spore germination
G8O30_07825	COG0705	Rhomboid family
G8O30_07825	COG0457	Tetratricopeptide repeat
G8O30_07830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G8O30_07865	COG0704	Plays a role in the regulation of phosphate uptake
G8O30_07870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G8O30_07875	COG0581	inorganic phosphate transmembrane transporter activity
G8O30_07880	COG0573	inorganic phosphate transmembrane transporter activity
G8O30_07885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G8O30_07890	COG0768	penicillin binding
G8O30_07895	COG0477	Major facilitator Superfamily
G8O30_07905	COG2839	Protein conserved in bacteria
G8O30_07910	COG1283	sodium-dependent phosphate transmembrane transporter activity
G8O30_07920	COG0840	transmembrane signaling receptor activity
G8O30_07925	COG2814	Major facilitator Superfamily
G8O30_07940	COG4709	membrane
G8O30_07945	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
G8O30_07950	COG0735	belongs to the Fur family
G8O30_07955	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G8O30_07960	COG1121	(ABC) transporter
G8O30_07965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8O30_07975	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
G8O30_07980	COG0513	Belongs to the DEAD box helicase family
G8O30_07990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G8O30_07995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G8O30_08000	COG2384	SAM-dependent methyltransferase
G8O30_08005	COG2010	Cytochrome c
G8O30_08010	COG1960	acyl-CoA dehydrogenase activity
G8O30_08020	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G8O30_08025	COG0358	DNA primase activity
G8O30_08030	COG1671	Belongs to the UPF0178 family
G8O30_08040	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G8O30_08045	COG0517	IMP dehydrogenase activity
G8O30_08050	COG0751	glycine-tRNA ligase activity
G8O30_08055	COG0752	glycyl-tRNA synthetase alpha subunit
G8O30_08060	COG1381	Involved in DNA repair and RecF pathway recombination
G8O30_08075	COG0295	cytidine deaminase activity
G8O30_08080	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
G8O30_08090	COG1480	7TM receptor with intracellular HD hydrolase
G8O30_08095	COG1702	phosphate starvation-inducible protein PhoH
G8O30_08120	COG4864	UPF0365 protein
G8O30_08125	COG1030	water channel activity
G8O30_08130	COG1610	YqeY-like protein
G8O30_08140	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G8O30_08145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G8O30_08155	COG2264	protein methyltransferase activity
G8O30_08160	COG0484	heat shock protein binding
G8O30_08165	COG0443	Heat shock 70 kDa protein
G8O30_08170	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G8O30_08180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G8O30_08200	COG0860	N-Acetylmuramoyl-L-alanine amidase
G8O30_08215	COG1466	dna polymerase III delta subunit
G8O30_08225	COG2333	competence protein COMEC
G8O30_08225	COG0658	competence protein
G8O30_08230	COG2333	competence protein COMEC
G8O30_08230	COG0658	competence protein
G8O30_08235	COG2131	deaminase
G8O30_08240	COG1555	photosystem II stabilization
G8O30_08245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G8O30_08250	COG2226	methyltransferase
G8O30_08255	COG0799	negative regulation of ribosome biogenesis
G8O30_08260	COG1713	HD superfamily hydrolase involved in NAD metabolism
G8O30_08265	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G8O30_08270	COG1534	Rna-binding protein
G8O30_08275	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G8O30_08280	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
G8O30_08285	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
G8O30_08295	COG0688	phosphatidylethanolamine metabolic process
G8O30_08315	COG0346	lactoylglutathione lyase activity
G8O30_08325	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
G8O30_08360	COG1247	-acetyltransferase
G8O30_08365	COG4221	oxidoreductase activity
G8O30_08385	COG0626	cystathionine gamma-synthase activity
G8O30_08390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G8O30_08395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G8O30_08400	COG2226	methyltransferase
G8O30_08410	COG0768	penicillin binding
G8O30_08415	COG0768	penicillin binding
G8O30_08420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G8O30_08425	COG0572	uridine kinase
G8O30_08430	COG0826	peptidase U32
G8O30_08435	COG0826	peptidase U32
G8O30_08440	COG4122	O-methyltransferase activity
G8O30_08445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G8O30_08450	COG3906	Belongs to the UPF0473 family
G8O30_08465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G8O30_08470	COG0628	permease
G8O30_08485	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G8O30_08495	COG0482	sulfurtransferase activity
G8O30_08500	COG1104	cysteine desulfurase activity
G8O30_08505	COG1959	2 iron, 2 sulfur cluster binding
G8O30_08510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G8O30_08515	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
G8O30_08520	COG1131	(ABC) transporter
G8O30_08525	COG1131	(ABC) transporter
G8O30_08530	COG1725	Transcriptional regulator
G8O30_08540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G8O30_08550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G8O30_08555	COG0124	histidyl-tRNA synthetase
G8O30_08565	COG0860	N-Acetylmuramoyl-L-alanine amidase
G8O30_08565	COG3103	Sh3 type 3 domain protein
G8O30_08565	COG4991	sh3 domain protein
G8O30_08570	COG1490	D-aminoacyl-tRNA deacylase activity
G8O30_08575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G8O30_08580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G8O30_08585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G8O30_08585	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
G8O30_08590	COG5416	Lipopolysaccharide assembly protein A domain
G8O30_08595	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G8O30_08600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G8O30_08600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G8O30_08610	COG2244	polysaccharide biosynthetic process
G8O30_08615	COG2323	membrane
G8O30_08625	COG1862	Preprotein translocase
G8O30_08640	COG2255	four-way junction helicase activity
G8O30_08645	COG0632	four-way junction helicase activity
G8O30_08665	COG1388	LysM domain
G8O30_08670	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G8O30_08675	COG0157	Belongs to the NadC ModD family
G8O30_08680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G8O30_08685	COG1104	cysteine desulfurase activity
G8O30_08690	COG1827	regulation of RNA biosynthetic process
G8O30_08695	COG0077	Prephenate dehydratase
G8O30_08700	COG4492	Belongs to the UPF0735 family
G8O30_08705	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G8O30_08710	COG3290	protein histidine kinase activity
G8O30_08720	COG2868	ribosomal protein
G8O30_08725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G8O30_08730	COG1530	ribonuclease E activity
G8O30_08735	COG1994	Peptidase M50
G8O30_08745	COG2894	cell division
G8O30_08750	COG0850	regulation of cytokinetic process
G8O30_08755	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
G8O30_08760	COG1792	Involved in formation and maintenance of cell shape
G8O30_08765	COG1077	Cell shape determining protein MreB Mrl
G8O30_08770	COG2003	Belongs to the UPF0758 family
G8O30_08785	COG2165	general secretion pathway protein
G8O30_08800	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G8O30_08805	COG2165	general secretion pathway protein
G8O30_08810	COG1459	type II secretion system
G8O30_08820	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G8O30_08860	COG3706	GGDEF domain
G8O30_08865	COG0285	dihydrofolate synthase activity
G8O30_08870	COG0525	valine-tRNA ligase activity
G8O30_08875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G8O30_08880	COG1388	LysM domain
G8O30_08885	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G8O30_08890	COG0113	porphobilinogen synthase activity
G8O30_08900	COG0181	hydroxymethylbilane synthase activity
G8O30_08905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G8O30_08920	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G8O30_08925	COG0602	queuosine metabolic process
G8O30_08930	COG0720	synthase
G8O30_08935	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G8O30_08940	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G8O30_08955	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G8O30_08960	COG0544	peptidyl-prolyl cis-trans isomerase activity
G8O30_09015	COG5632	N-Acetylmuramoyl-L-alanine amidase
G8O30_09015	COG3409	Peptidoglycan-binding domain 1 protein
G8O30_09020	COG4824	toxin secretion phage lysis holin
G8O30_09120	COG0740	serine-type endopeptidase activity
G8O30_09175	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G8O30_09195	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
G8O30_09210	COG1484	DNA-dependent DNA replication
G8O30_09215	COG3935	DnaD domain protein
G8O30_09220	COG3723	Recombinational DNA repair protein, rece pathway
G8O30_09225	COG5377	YqaJ viral recombinase family
G8O30_09235	COG2002	toxin-antitoxin pair type II binding
G8O30_09270	COG1396	sequence-specific DNA binding
G8O30_09290	COG0622	Phosphoesterase
G8O30_09300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G8O30_09305	COG5401	PFAM Sporulation and spore germination
G8O30_09310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G8O30_09315	COG1846	Transcriptional regulator
G8O30_09320	COG2197	response regulator
G8O30_09325	COG1070	Carbohydrate kinase
G8O30_09335	COG0824	Thioesterase
G8O30_09340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G8O30_09345	COG1053	succinate dehydrogenase
G8O30_09350	COG2009	succinate dehydrogenase
G8O30_09355	COG1719	4-vinyl reductase, 4VR
G8O30_09365	COG0322	excinuclease ABC activity
G8O30_09370	COG3118	belongs to the thioredoxin family
G8O30_09375	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G8O30_09380	COG2086	electron transfer activity
G8O30_09385	COG1024	Enoyl-CoA hydratase
G8O30_09390	COG1309	transcriptional regulator
G8O30_09395	COG0318	PFAM AMP-dependent synthetase and ligase
G8O30_09400	COG3766	membrane
G8O30_09405	COG1193	negative regulation of DNA recombination
G8O30_09410	COG1796	DNA polymerase
G8O30_09410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
G8O30_09415	COG1286	toxin biosynthetic process
G8O30_09430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8O30_09430	COG0072	phenylalanine-tRNA ligase activity
G8O30_09435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G8O30_09440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8O30_09450	COG1363	Peptidase, m42
G8O30_09470	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G8O30_09480	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G8O30_09500	COG1484	DNA-dependent DNA replication
G8O30_09505	COG3611	Membrane attachment protein
G8O30_09510	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G8O30_09525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G8O30_09535	COG1971	Probably functions as a manganese efflux pump
G8O30_09540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G8O30_09545	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G8O30_09545	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G8O30_09555	COG0330	HflC and HflK could
G8O30_09560	COG5002	protein histidine kinase activity
G8O30_09565	COG0745	RESPONSE REGULATOR receiver
G8O30_09575	COG0039	L-malate dehydrogenase activity
G8O30_09580	COG0538	isocitrate dehydrogenase activity
G8O30_09585	COG0372	Belongs to the citrate synthase family
G8O30_09590	COG0628	permease
G8O30_09595	COG3030	protein affecting phage T7 exclusion by the F plasmid
G8O30_09605	COG0205	6-phosphofructokinase activity
G8O30_09610	COG0825	malonyl-CoA metabolic process
G8O30_09615	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G8O30_09620	COG1725	Transcriptional regulator
G8O30_09625	COG0281	malic enzyme
G8O30_09630	COG0587	DNA-directed DNA polymerase activity
G8O30_09635	COG0587	DNA-directed DNA polymerase activity
G8O30_09650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G8O30_09660	COG4109	DRTGG domain
G8O30_09675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G8O30_09680	COG0006	proline dipeptidase activity
G8O30_09710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G8O30_09715	COG0827	DNA restriction-modification system
G8O30_09720	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
G8O30_09725	COG3874	Sporulation protein YtfJ
G8O30_09735	COG1714	RDD family
G8O30_09740	COG0616	signal peptide processing
G8O30_09745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G8O30_09750	COG2962	Rard protein
G8O30_09755	COG1574	metal-dependent hydrolase with the TIM-barrel fold
G8O30_09760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G8O30_09775	COG1104	cysteine desulfurase activity
G8O30_09790	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
G8O30_09795	COG1309	transcriptional regulator
G8O30_09800	COG1956	GAF domain-containing protein
G8O30_09805	COG2203	Gaf domain
G8O30_09805	COG2199	diguanylate cyclase activity
G8O30_09815	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G8O30_09830	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G8O30_09840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G8O30_09845	COG0454	-acetyltransferase
G8O30_09850	COG0123	including yeast histone deacetylase and acetoin utilization protein
G8O30_09865	COG1609	Transcriptional regulator
G8O30_09870	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G8O30_09870	COG1605	Chorismate mutase
G8O30_09875	COG0849	cell division
G8O30_09880	COG3118	belongs to the thioredoxin family
G8O30_09885	COG4980	gas vesicle protein
G8O30_09900	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G8O30_09905	COG1674	ftsk spoiiie
G8O30_09905	COG1674	ftsk spoiiie
G8O30_09910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8O30_09915	COG4848	Belongs to the UPF0354 family
G8O30_09920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G8O30_09935	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
G8O30_09940	COG1363	Peptidase, m42
G8O30_09950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G8O30_09955	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G8O30_09965	COG0510	thiamine kinase activity
G8O30_09970	COG1523	belongs to the glycosyl hydrolase 13 family
G8O30_09980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G8O30_09990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8O30_10000	COG1349	DNA-binding transcription factor activity
G8O30_10005	COG1187	pseudouridine synthase activity
G8O30_10015	COG2081	HI0933 family
G8O30_10030	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G8O30_10035	COG0495	leucyl-tRNA aminoacylation
G8O30_10040	COG2814	Major facilitator Superfamily
G8O30_10055	COG1242	4 iron, 4 sulfur cluster binding
G8O30_10060	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
G8O30_10065	COG2197	response regulator
G8O30_10070	COG4585	Histidine kinase
G8O30_10075	COG3239	Fatty acid desaturase
G8O30_10085	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8O30_10095	COG2267	carboxylic ester hydrolase activity
G8O30_10100	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
G8O30_10105	COG4990	cell redox homeostasis
G8O30_10110	COG0367	asparagine synthase
G8O30_10115	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G8O30_10120	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
G8O30_10130	COG1506	peptidase
G8O30_10135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8O30_10140	COG1116	anion transmembrane transporter activity
G8O30_10145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8O30_10150	COG0494	nUDIX hydrolase
G8O30_10160	COG4824	toxin secretion phage lysis holin
G8O30_10165	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G8O30_10170	COG1854	S-ribosylhomocysteine lyase activity
G8O30_10180	COG0783	Belongs to the Dps family
G8O30_10190	COG1271	oxidase subunit
G8O30_10195	COG1294	oxidase, subunit
G8O30_10205	COG4948	Mandelate Racemase Muconate Lactonizing
G8O30_10215	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G8O30_10220	COG0596	Alpha beta hydrolase
G8O30_10230	COG1169	isochorismate synthase
G8O30_10235	COG1575	Belongs to the MenA family. Type 1 subfamily
G8O30_10240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G8O30_10245	COG0058	SHG alpha-glucan phosphorylase activity
G8O30_10250	COG0297	glycogen (starch) synthase activity
G8O30_10255	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G8O30_10390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G8O30_10405	COG1979	alcohol dehydrogenase
G8O30_10410	COG2155	Conserved Protein
G8O30_10415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G8O30_10420	COG1012	belongs to the aldehyde dehydrogenase family
G8O30_10425	COG1098	S1 RNA binding domain
G8O30_10430	COG2267	carboxylic ester hydrolase activity
G8O30_10440	COG2032	superoxide dismutase activity
G8O30_10450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G8O30_10460	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8O30_10465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8O30_10480	COG2111	Na H antiporter
G8O30_10480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G8O30_10485	COG2111	Na H antiporter
G8O30_10490	COG1006	Multisubunit Na H antiporter MnhC subunit
G8O30_10495	COG0651	ATP synthesis coupled electron transport
G8O30_10500	COG1863	multisubunit Na H antiporter MnhE subunit
G8O30_10505	COG2212	antiporter activity
G8O30_10510	COG1320	monovalent cation:proton antiporter activity
G8O30_10515	COG2050	protein possibly involved in aromatic compounds catabolism
G8O30_10525	COG2056	Na+-H+ antiporter family
G8O30_10530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G8O30_10535	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
G8O30_10540	COG3584	3D domain protein
G8O30_10560	COG1252	NADH dehydrogenase
G8O30_10565	COG0492	ferredoxin-NADP+ reductase activity
G8O30_10640	COG4974	Belongs to the 'phage' integrase family
G8O30_10645	COG0316	Belongs to the HesB IscA family
G8O30_10655	COG4844	belongs to the
G8O30_10660	COG1252	NADH dehydrogenase
G8O30_10665	COG4837	Protein of unknown function (DUF1462)
G8O30_10670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G8O30_10675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8O30_10680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G8O30_10685	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G8O30_10690	COG0647	UMP catabolic process
G8O30_10695	COG2445	Protein of unknown function DUF86
G8O30_10710	COG4470	Protein conserved in bacteria
G8O30_10725	COG0739	heme binding
G8O30_10735	COG0733	neurotransmitter:sodium symporter activity
G8O30_10740	COG1757	Na H antiporter
G8O30_10750	COG3377	Domain of unknown function (DUF1805)
G8O30_10755	COG0737	Belongs to the 5'-nucleotidase family
G8O30_10760	COG0730	response to heat
G8O30_10765	COG1801	Protein of unknown function DUF72
G8O30_10770	COG0719	Fe-S assembly protein
G8O30_10775	COG0822	iron-sulfur transferase activity
G8O30_10780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G8O30_10785	COG0719	Fe-S assembly protein
G8O30_10790	COG0396	ATPase activity
G8O30_10795	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G8O30_10800	COG1464	Belongs to the NlpA lipoprotein family
G8O30_10805	COG2011	ABC-type metal ion transport system permease component
G8O30_10810	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G8O30_10820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G8O30_10825	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
G8O30_10835	COG0509	glycine decarboxylation via glycine cleavage system
G8O30_10840	COG1393	Belongs to the ArsC family
G8O30_10845	COG0640	Transcriptional regulator
G8O30_10850	COG0300	oxidoreductase activity
G8O30_10855	COG1960	acyl-CoA dehydrogenase activity
G8O30_10860	COG0183	Belongs to the thiolase family
G8O30_10865	COG1024	Enoyl-CoA hydratase
G8O30_10865	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8O30_10875	COG0506	proline dehydrogenase activity
G8O30_10885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8O30_10890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8O30_10895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G8O30_10925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G8O30_10930	COG2340	Cysteine-rich secretory protein family
G8O30_10935	COG2340	Cysteine-rich secretory protein family
G8O30_10940	COG1283	sodium-dependent phosphate transmembrane transporter activity
G8O30_10945	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
G8O30_10950	COG1120	ATPase activity
G8O30_10955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G8O30_10955	COG3153	acetyltransferase
G8O30_10975	COG2217	Heavy metal translocating P-type atpase
G8O30_10980	COG2608	mercury ion transmembrane transporter activity
G8O30_10985	COG1937	Protein conserved in bacteria
G8O30_10990	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
G8O30_11000	COG0697	spore germination
G8O30_11010	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G8O30_11015	COG0557	exoribonuclease II activity
G8O30_11020	COG1647	Serine aminopeptidase, S33
G8O30_11025	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G8O30_11030	COG0148	phosphopyruvate hydratase activity
G8O30_11050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G8O30_11080	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G8O30_11090	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G8O30_11095	COG1660	Displays ATPase and GTPase activities
G8O30_11100	COG1051	belongs to the nudix hydrolase family
G8O30_11105	COG0492	ferredoxin-NADP+ reductase activity
G8O30_11110	COG0457	Tetratricopeptide repeat
G8O30_11115	COG0140	phosphoribosyl-ATP diphosphatase activity
G8O30_11115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G8O30_11120	COG0107	imidazoleglycerol-phosphate synthase activity
G8O30_11125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G8O30_11130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G8O30_11135	COG0131	Imidazoleglycerol-phosphate dehydratase
G8O30_11140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G8O30_11145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G8O30_11150	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G8O30_11155	COG0110	maltose O-acetyltransferase activity
G8O30_11165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
G8O30_11175	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G8O30_11180	COG1950	PFAM Membrane protein of
G8O30_11185	COG1983	PspC domain protein
G8O30_11190	COG3595	metallopeptidase activity
G8O30_11205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G8O30_11230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8O30_11235	COG3409	Peptidoglycan-binding domain 1 protein
G8O30_11235	COG0793	Belongs to the peptidase S41A family
G8O30_11245	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8O30_11250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G8O30_11255	COG1116	anion transmembrane transporter activity
G8O30_11260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8O30_11275	COG0626	cystathionine gamma-synthase activity
G8O30_11280	COG0840	transmembrane signaling receptor activity
G8O30_11285	COG0739	heme binding
G8O30_11290	COG2177	Part of the ABC transporter FtsEX involved in
G8O30_11295	COG2884	Cell division ATP-binding protein ftsE
G8O30_11305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
G8O30_11315	COG0653	protein targeting
G8O30_11330	COG2059	Chromate
G8O30_11335	COG2059	Chromate
G8O30_11365	COG1516	flagellar protein fliS
G8O30_11370	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
G8O30_11375	COG1334	flagellar protein FlaG
G8O30_11380	COG4085	toxin activity
G8O30_11380	COG0737	Belongs to the 5'-nucleotidase family
G8O30_11380	COG1525	nuclease
G8O30_11410	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G8O30_11415	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
G8O30_11425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G8O30_11430	COG4786	Flagellar basal body rod
G8O30_11430	COG1256	bacterial-type flagellum assembly
G8O30_11450	COG1040	competence protein
G8O30_11455	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
G8O30_11460	COG1307	EDD domain protein, DegV family
G8O30_11470	COG2197	response regulator
G8O30_11475	COG4585	Histidine kinase
G8O30_11480	COG1739	Uncharacterized protein family UPF0029
G8O30_11485	COG1316	TRANSCRIPTIONal
G8O30_11490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G8O30_11500	COG2244	polysaccharide biosynthetic process
G8O30_11510	COG5263	repeat protein
G8O30_11510	COG4193	domain, Protein
G8O30_11515	COG0653	protein targeting
G8O30_11525	COG4085	toxin activity
G8O30_11525	COG0737	Belongs to the 5'-nucleotidase family
G8O30_11525	COG1525	nuclease
G8O30_11555	COG0726	polysaccharide deacetylase
G8O30_11585	COG1696	Membrane protein involved in D-alanine export
G8O30_11630	COG4974	Belongs to the 'phage' integrase family
G8O30_11645	COG4974	Belongs to the 'phage' integrase family
G8O30_11655	COG4974	Belongs to the 'phage' integrase family
G8O30_11685	COG0791	NLP P60 protein
G8O30_11695	COG0860	N-Acetylmuramoyl-L-alanine amidase
G8O30_11705	COG1404	Belongs to the peptidase S8 family
G8O30_11730	COG0210	DNA helicase
G8O30_11735	COG1193	negative regulation of DNA recombination
G8O30_11750	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
G8O30_11755	COG1473	amidohydrolase
G8O30_11760	COG2508	Transcriptional regulator
G8O30_11770	COG1404	Belongs to the peptidase S8 family
G8O30_11800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G8O30_11805	COG2011	ABC-type metal ion transport system permease component
G8O30_11865	COG2304	oxidoreductase activity
G8O30_11880	COG1619	proteins homologs of microcin C7 resistance protein MccF
G8O30_11915	COG1523	belongs to the glycosyl hydrolase 13 family
G8O30_11925	COG1028	Short-chain dehydrogenase reductase Sdr
G8O30_11935	COG1131	(ABC) transporter
G8O30_11990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G8O30_11995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G8O30_12000	COG0716	FMN binding
G8O30_12015	COG3290	protein histidine kinase activity
G8O30_12015	COG0840	transmembrane signaling receptor activity
G8O30_12020	COG2323	membrane
G8O30_12060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G8O30_12110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G8O30_12145	COG1215	transferase activity, transferring glycosyl groups
G8O30_12150	COG0438	transferase activity, transferring glycosyl groups
G8O30_12160	COG1181	Belongs to the D-alanine--D-alanine ligase family
G8O30_12165	COG0363	glucosamine-6-phosphate deaminase activity
G8O30_12170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G8O30_12180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G8O30_12190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G8O30_12205	COG4464	protein tyrosine phosphatase activity
G8O30_12210	COG0489	protein tyrosine kinase activity
G8O30_12215	COG3944	biosynthesis protein
G8O30_12225	COG0791	NLP P60 protein
G8O30_12225	COG1388	LysM domain
G8O30_12230	COG1216	Glycosyl transferase, family 2
G8O30_12235	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G8O30_12240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G8O30_12265	COG1984	allophanate hydrolase subunit 2
G8O30_12270	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G8O30_12275	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G8O30_12280	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
G8O30_12295	COG4715	Zinc finger, swim domain protein
G8O30_12300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G8O30_12310	COG0629	single-stranded DNA binding
G8O30_12350	COG4786	Flagellar basal body rod
G8O30_12355	COG4786	Flagellar basal body rod
G8O30_12360	COG1077	Cell shape determining protein MreB Mrl
G8O30_12365	COG1609	Transcriptional regulator
G8O30_12370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G8O30_12380	COG0739	heme binding
G8O30_12390	COG2385	sporulation resulting in formation of a cellular spore
G8O30_12405	COG4836	Membrane
G8O30_12410	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G8O30_12415	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G8O30_12420	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G8O30_12425	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G8O30_12430	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G8O30_12440	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G8O30_12445	COG0356	it plays a direct role in the translocation of protons across the membrane
G8O30_12460	COG1404	Belongs to the peptidase S8 family
G8O30_12465	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G8O30_12470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G8O30_12480	COG4475	Protein of unknown function (DUF436)
G8O30_12485	COG0698	ribose 5-phosphate isomerase
G8O30_12490	COG0840	transmembrane signaling receptor activity
G8O30_12500	COG1971	Probably functions as a manganese efflux pump
G8O30_12505	COG0009	L-threonylcarbamoyladenylate synthase
G8O30_12525	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G8O30_12540	COG1435	thymidine kinase activity
G8O30_12545	COG0254	rRNA binding
G8O30_12550	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G8O30_12555	COG1494	fructose-1,6-bisphosphatase
G8O30_12595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G8O30_12600	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G8O30_12605	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G8O30_12615	COG2204	response regulator
G8O30_12620	COG4821	SIS domain
G8O30_12625	COG0504	CTP synthase activity
G8O30_12630	COG3343	RNA polymerase activity
G8O30_12635	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G8O30_12635	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G8O30_12635	COG1703	isobutyryl-CoA mutase activity
G8O30_12645	COG1960	acyl-CoA dehydrogenase activity
G8O30_12650	COG1960	acyl-CoA dehydrogenase activity
G8O30_12655	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8O30_12660	COG0183	Belongs to the thiolase family
G8O30_12665	COG0247	lactate metabolic process
G8O30_12665	COG2181	nitrate reductase activity
G8O30_12670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8O30_12675	COG4294	response to UV
G8O30_12680	COG1115	amino acid carrier protein
G8O30_12685	COG0018	arginyl-trna synthetase
G8O30_12695	COG0010	Belongs to the arginase family
G8O30_12700	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G8O30_12705	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8O30_12715	COG1994	Peptidase M50
G8O30_12720	COG1942	4-Oxalocrotonate Tautomerase
G8O30_12725	COG3465	dGTPase activity
G8O30_12730	COG1078	dGTPase activity
G8O30_12745	COG0095	Lipoate-protein ligase
G8O30_12750	COG0280	phosphate acetyltransferase
G8O30_12755	COG3253	May function as heme-dependent peroxidase
G8O30_12760	COG3773	Cell wall hydrolase
G8O30_12770	COG2363	Small membrane protein
G8O30_12785	COG1404	Belongs to the peptidase S8 family
G8O30_12790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G8O30_12795	COG0351	phosphomethylpyrimidine kinase
G8O30_12800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G8O30_12805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G8O30_12825	COG1621	beta-fructofuranosidase activity
G8O30_12835	COG1263	PTS System
G8O30_12835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8O30_12840	COG3711	transcriptional antiterminator
G8O30_12845	COG0561	phosphatase activity
G8O30_12850	COG3314	Sporulation integral membrane protein YlbJ
G8O30_12855	COG4191	Histidine kinase
G8O30_12865	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G8O30_12890	COG3263	regulation of cellular component size
G8O30_12895	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G8O30_12900	COG0156	8-amino-7-oxononanoate synthase activity
G8O30_12905	COG2814	Major facilitator Superfamily
G8O30_12910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G8O30_12915	COG0366	Alpha amylase catalytic
G8O30_12920	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G8O30_12935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8O30_12935	COG2190	(PTS) system
G8O30_12935	COG1263	PTS System
G8O30_12945	COG4536	flavin adenine dinucleotide binding
G8O30_12950	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G8O30_12955	COG3766	membrane
G8O30_12965	COG1842	Phage shock protein A
G8O30_12985	COG3546	catalase activity
G8O30_12995	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8O30_12995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8O30_13000	COG5577	PFAM Coat F domain
G8O30_13010	COG0386	Belongs to the glutathione peroxidase family
G8O30_13015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G8O30_13020	COG2094	Belongs to the DNA glycosylase MPG family
G8O30_13035	COG0737	Belongs to the 5'-nucleotidase family
G8O30_13040	COG0737	Belongs to the 5'-nucleotidase family
G8O30_13040	COG1525	nuclease
G8O30_13040	COG4085	toxin activity
G8O30_13050	COG0753	catalase activity
G8O30_13060	COG2814	Major facilitator Superfamily
G8O30_13065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G8O30_13070	COG4187	Peptidase family M20/M25/M40
G8O30_13080	COG0655	NAD(P)H dehydrogenase (quinone) activity
G8O30_13085	COG1263	PTS System
G8O30_13085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
G8O30_13090	COG0366	Alpha amylase catalytic
G8O30_13095	COG2188	Transcriptional regulator
G8O30_13100	COG1733	regulation of RNA biosynthetic process
G8O30_13105	COG2814	Major facilitator Superfamily
G8O30_13115	COG1979	alcohol dehydrogenase
G8O30_13120	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G8O30_13125	COG1301	dicarboxylic acid transport
G8O30_13130	COG3706	GGDEF domain
G8O30_13135	COG1187	pseudouridine synthase activity
G8O30_13140	COG0390	transport system, permease component
G8O30_13150	COG3152	Membrane
G8O30_13155	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G8O30_13160	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G8O30_13170	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
G8O30_13185	COG0778	Nitroreductase
G8O30_13190	COG0673	inositol 2-dehydrogenase activity
G8O30_13195	COG2195	Cleaves the N-terminal amino acid of tripeptides
G8O30_13210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8O30_13215	COG3314	Sporulation integral membrane protein YlbJ
G8O30_13235	COG0861	Integral membrane protein TerC family
G8O30_13240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
G8O30_13245	COG0579	oxidoreductase
G8O30_13250	COG0450	alkyl hydroperoxide reductase
G8O30_13255	COG3634	alkyl hydroperoxide reductase activity
G8O30_13260	COG0840	transmembrane signaling receptor activity
G8O30_13265	COG1307	EDD domain protein, DegV family
G8O30_13275	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G8O30_13280	COG0300	oxidoreductase activity
G8O30_13285	COG0456	acetyltransferase
G8O30_13290	COG3573	Dehydrogenase
G8O30_13295	COG0415	Belongs to the DNA photolyase family
G8O30_13310	COG5609	conserved protein (DUF2294)
G8O30_13345	COG0456	acetyltransferase
G8O30_13345	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
G8O30_13360	COG1595	DNA-templated transcription, initiation
G8O30_13375	COG0662	Cupin 2, conserved barrel domain protein
G8O30_13435	COG0791	NLP P60 protein
G8O30_13435	COG1388	LysM domain
G8O30_13440	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G8O30_13460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8O30_13460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8O30_13475	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G8O30_13480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8O30_13490	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
G8O30_13495	COG4853	Protein conserved in bacteria
G8O30_13500	COG4863	YycH protein
G8O30_13505	COG5002	protein histidine kinase activity
G8O30_13510	COG0745	RESPONSE REGULATOR receiver
G8O30_13515	COG0739	heme binding
G8O30_13515	COG1196	nuclear chromosome segregation
G8O30_13515	COG0741	lytic transglycosylase activity
G8O30_13535	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G8O30_13540	COG0305	Participates in initiation and elongation during chromosome replication
G8O30_13550	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
G8O30_13555	COG4241	membrane
G8O30_13565	COG0629	single-stranded DNA binding
G8O30_13575	COG0438	transferase activity, transferring glycosyl groups
G8O30_13585	COG0012	GTP binding
G8O30_13590	COG4481	Protein conserved in bacteria
G8O30_13595	COG0668	transmembrane transport
G8O30_13605	COG1811	Na channel or pump
G8O30_13610	COG1475	DNA binding
G8O30_13615	COG1192	Involved in chromosome partitioning
G8O30_13630	COG0357	Ribosomal RNA small subunit methyltransferase G
G8O30_13635	COG0445	tRNA wobble uridine modification
G8O30_13640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G8O30_13645	COG1847	R3H domain protein
G8O30_13655	COG0594	ribonuclease P activity
G8O30_13660	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G8O30_13665	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G8O30_13670	COG0592	DNA-directed DNA polymerase activity
G8O30_13675	COG2501	S4 domain
G8O30_13680	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G8O30_13690	COG0187	DNA topoisomerase II activity
G8O30_13695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G8O30_13700	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
G8O30_13740	COG0517	IMP dehydrogenase activity
G8O30_13740	COG0516	GMP reductase activity
G8O30_13755	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
G8O30_13770	COG1428	Deoxynucleoside kinase
G8O30_13775	COG1428	Deoxynucleoside kinase
G8O30_13780	COG3858	chitin binding
G8O30_13780	COG1388	LysM domain
G8O30_13785	COG1335	isochorismatase
G8O30_13790	COG0590	tRNA wobble adenosine to inosine editing
G8O30_13800	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G8O30_13805	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G8O30_13840	COG1982	Orn Lys Arg decarboxylase major
G8O30_13845	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G8O30_13850	COG3870	Protein conserved in bacteria
G8O30_13855	COG1728	Protein conserved in bacteria
G8O30_13860	COG1774	PSP1 C-terminal conserved region
G8O30_13865	COG4467	Involved in initiation control of chromosome replication
G8O30_13870	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
G8O30_13875	COG2827	Endonuclease containing a URI domain
G8O30_13880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G8O30_13885	COG2002	toxin-antitoxin pair type II binding
G8O30_13890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8O30_13890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8O30_13895	COG0084	hydrolase, TatD family'
G8O30_13900	COG3584	3D domain protein
G8O30_13900	COG3583	domain protein
G8O30_13920	COG4466	Protein conserved in bacteria
G8O30_13930	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G8O30_13935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G8O30_13940	COG0251	oxidation-reduction process
G8O30_13945	COG2088	sporulation resulting in formation of a cellular spore
G8O30_13950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G8O30_13960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G8O30_13965	COG0193	aminoacyl-tRNA hydrolase activity
G8O30_13975	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G8O30_13980	COG2002	toxin-antitoxin pair type II binding
G8O30_13985	COG2244	polysaccharide biosynthetic process
G8O30_13990	COG3956	TIGRFAM MazG family protein
G8O30_13995	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G8O30_14015	COG1098	S1 RNA binding domain
G8O30_14030	COG2208	phosphoserine phosphatase activity
G8O30_14035	COG2304	oxidoreductase activity
G8O30_14040	COG0515	serine threonine protein kinase
G8O30_14045	COG0037	tRNA processing
G8O30_14045	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
G8O30_14050	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
G8O30_14055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G8O30_14060	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G8O30_14065	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G8O30_14070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G8O30_14075	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G8O30_14080	COG0512	Glutamine amidotransferase of anthranilate synthase
G8O30_14085	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G8O30_14090	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G8O30_14095	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G8O30_14100	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G8O30_14105	COG1396	sequence-specific DNA binding
G8O30_14110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G8O30_14210	COG0542	response to heat
G8O30_14215	COG3869	Catalyzes the specific phosphorylation of arginine residues in
G8O30_14220	COG0542	response to heat
G8O30_14225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G8O30_14235	COG4956	integral membrane protein (PIN domain superfamily)
G8O30_14245	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G8O30_14255	COG1045	serine acetyltransferase
G8O30_14260	COG0215	cysteine-tRNA ligase activity
G8O30_14270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8O30_14275	COG3688	RNA-binding protein containing a PIN domain
G8O30_14285	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G8O30_14290	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G8O30_14295	COG0250	Participates in transcription elongation, termination and antitermination
G8O30_14305	COG0081	regulation of translation
G8O30_14315	COG0222	ribosome binding
G8O30_14320	COG2813	Specifically methylates the guanine in position
G8O30_14325	COG0085	RNA polymerase activity
G8O30_14330	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G8O30_14335	COG1358	cellular component organization or biogenesis
G8O30_14340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G8O30_14355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G8O30_14365	COG0051	transcription antitermination factor activity, RNA binding
G8O30_14370	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G8O30_14375	COG0088	Forms part of the polypeptide exit tunnel
G8O30_14385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G8O30_14390	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G8O30_14395	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G8O30_14400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G8O30_14405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G8O30_14410	COG0255	Belongs to the universal ribosomal protein uL29 family
G8O30_14415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G8O30_14425	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G8O30_14430	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G8O30_14435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G8O30_14450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G8O30_14455	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G8O30_14460	COG1841	ribosomal large subunit assembly
G8O30_14470	COG0201	protein transport
G8O30_14475	COG0563	adenylate kinase activity
G8O30_14480	COG0024	Methionine aminopeptidase
G8O30_14485	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G8O30_14490	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G8O30_14495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G8O30_14505	COG0202	RNA polymerase activity
G8O30_14510	COG0203	ribosomal protein L17
G8O30_14515	COG1122	ATPase activity
G8O30_14525	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G8O30_14530	COG0101	tRNA pseudouridine synthase activity
G8O30_14535	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G8O30_14540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G8O30_14550	COG0860	N-Acetylmuramoyl-L-alanine amidase
G8O30_14555	COG0489	protein tyrosine kinase activity
G8O30_14565	COG2194	sulfuric ester hydrolase activity
G8O30_14570	COG0726	polysaccharide deacetylase
G8O30_14645	COG1595	DNA-templated transcription, initiation
G8O30_14650	COG5662	AntiSigma factor
G8O30_14655	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
G8O30_14660	COG4856	YbbR-like protein
G8O30_14665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8O30_14670	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G8O30_14675	COG5646	InterPro IPR014922
G8O30_14680	COG1840	ABC-type Fe3 transport system, periplasmic component
G8O30_14690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G8O30_14695	COG0768	penicillin binding
G8O30_14700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G8O30_14705	COG1309	transcriptional regulator
G8O30_14710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G8O30_14720	COG2323	membrane
G8O30_14725	COG4989	oxidoreductase activity
G8O30_14745	COG2211	Major facilitator Superfamily
G8O30_14750	COG2323	membrane
G8O30_14830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G8O30_14835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8O30_14835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8O30_14850	COG1595	DNA-templated transcription, initiation
G8O30_14875	COG0456	acetyltransferase
G8O30_14880	COG0789	Transcriptional regulator
G8O30_14890	COG1522	sequence-specific DNA binding
G8O30_14900	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
G8O30_14905	COG1132	(ABC) transporter
G8O30_14925	COG1657	PFAM Prenyltransferase squalene oxidase
G8O30_14935	COG0569	domain protein
G8O30_14940	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G8O30_14945	COG1469	GTP cyclohydrolase I activity
G8O30_14950	COG1968	undecaprenyl-diphosphatase activity
G8O30_14960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G8O30_14960	COG2207	Transcriptional regulator
G8O30_14965	COG0475	glutathione-regulated potassium exporter activity
G8O30_14965	COG0589	response to stress
G8O30_14970	COG0840	transmembrane signaling receptor activity
G8O30_14985	COG1120	ATPase activity
G8O30_14990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8O30_14995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G8O30_15005	COG0840	transmembrane signaling receptor activity
G8O30_15015	COG3842	ATPase activity
G8O30_15020	COG1176	ABC-type spermidine putrescine transport system, permease component I
G8O30_15025	COG1177	transmembrane transport
G8O30_15030	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
G8O30_15050	COG4086	secreted protein
G8O30_15060	COG2770	Histidine kinase
G8O30_15060	COG3437	response regulator, receiver
G8O30_15080	COG2340	Cysteine-rich secretory protein family
G8O30_15085	COG1238	metal cluster binding
G8O30_15095	COG1253	flavin adenine dinucleotide binding
G8O30_15105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G8O30_15120	COG4134	Bacterial extracellular solute-binding protein
G8O30_15135	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G8O30_15140	COG0398	Pfam SNARE associated Golgi protein
G8O30_15160	COG2076	Multidrug Resistance protein
G8O30_15165	COG2076	Multidrug Resistance protein
G8O30_15170	COG1181	Belongs to the D-alanine--D-alanine ligase family
G8O30_15175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G8O30_15185	COG0513	Belongs to the DEAD box helicase family
G8O30_15190	COG4294	response to UV
G8O30_15195	COG3402	PFAM membrane-flanked domain
G8O30_15200	COG3428	Bacterial PH domain
G8O30_15215	COG0705	Rhomboid family
G8O30_15220	COG0736	holo-[acyl-carrier-protein] synthase activity
G8O30_15225	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G8O30_15230	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G8O30_15235	COG0864	Transcriptional regulator
G8O30_15240	COG2337	Toxic component of a toxin-antitoxin (TA) module
G8O30_15250	COG1366	Belongs to the anti-sigma-factor antagonist family
G8O30_15255	COG1366	Belongs to the anti-sigma-factor antagonist family
G8O30_15260	COG2172	sigma factor antagonist activity
G8O30_15265	COG2208	phosphoserine phosphatase activity
G8O30_15270	COG1366	Belongs to the anti-sigma-factor antagonist family
G8O30_15275	COG2172	sigma factor antagonist activity
G8O30_15280	COG1191	sigma factor activity
G8O30_15285	COG2208	phosphoserine phosphatase activity
G8O30_15290	COG2183	response to ionizing radiation
G8O30_15305	COG3091	SprT-like family
G8O30_15385	COG0802	atpase or kinase
G8O30_15390	COG1214	PFAM Peptidase M22, glycoprotease
G8O30_15395	COG0456	acetyltransferase
G8O30_15405	COG0488	(ABC) transporter
G8O30_15410	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
G8O30_15415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G8O30_15420	COG0805	protein transport
G8O30_15430	COG1266	CAAX protease self-immunity
G8O30_15435	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G8O30_15440	COG0459	protein refolding
G8O30_15445	COG0582	viral genome integration into host DNA
G8O30_15450	COG0582	viral genome integration into host DNA
G8O30_15505	COG4166	transmembrane transport
G8O30_15535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G8O30_15535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G8O30_15550	COG0840	transmembrane signaling receptor activity
G8O30_15570	COG3852	Histidine kinase
G8O30_15625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8O30_15630	COG3706	GGDEF domain
G8O30_15630	COG2203	Gaf domain
G8O30_15630	COG4251	negative regulation of phosphorylation
G8O30_15630	COG5001	Diguanylate cyclase
G8O30_15635	COG0840	transmembrane signaling receptor activity
G8O30_15635	COG3290	protein histidine kinase activity
G8O30_15640	COG1522	sequence-specific DNA binding
G8O30_15660	COG0714	Associated with various cellular activities
G8O30_15710	COG1595	DNA-templated transcription, initiation
G8O30_15720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G8O30_15725	COG0840	transmembrane signaling receptor activity
G8O30_15745	COG1309	transcriptional regulator
G8O30_15750	COG0477	Major facilitator Superfamily
G8O30_15790	COG2304	oxidoreductase activity
G8O30_15830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G8O30_15840	COG0714	Associated with various cellular activities
G8O30_15845	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
G8O30_15850	COG1305	Transglutaminase-like
G8O30_15855	COG0519	Catalyzes the synthesis of GMP from XMP
G8O30_15855	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G8O30_15860	COG2252	PERMEase
G8O30_15900	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
G8O30_15910	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G8O30_15915	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G8O30_15920	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
G8O30_15940	COG4824	toxin secretion phage lysis holin
G8O30_15945	COG3409	Peptidoglycan-binding domain 1 protein
G8O30_15945	COG5632	N-Acetylmuramoyl-L-alanine amidase
G8O30_15995	COG1396	sequence-specific DNA binding
G8O30_16030	COG2002	toxin-antitoxin pair type II binding
G8O30_16040	COG5377	YqaJ viral recombinase family
G8O30_16045	COG3723	Recombinational DNA repair protein, rece pathway
G8O30_16050	COG3935	DnaD domain protein