locus-tag class description CX649_00010 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) CX649_00035 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CX649_00040 ENOG4105E7W lamb ycsf family protein CX649_00050 ENOG4108JPW Aminotransferase CX649_00055 ENOG4105C26 Dehydrogenase CX649_00075 ENOG4105CE4 GlcNAc 6-P deacetylase CX649_00080 ENOG410904A RNA polymerase CX649_00090 ENOG4105DA5 (ABC) transporter CX649_00120 ENOG4105CIG ABC transporter CX649_00140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CX649_00145 ENOG4105BZU Histidine kinase CX649_00155 ENOG4105CHR reductase CX649_00170 ENOG410787A Pts system, glucitol sorbitol-specific CX649_00175 ENOG4105DZY Pts system, glucitol sorbitol-specific CX649_00185 ENOG4108V06 Glutathione peroxidase CX649_00190 ENOG41069FQ Metallo-beta-lactamase superfamily CX649_00195 ENOG4105RWS endonuclease I CX649_00215 ENOG4105CTS PTS system mannitol-specific CX649_00225 ENOG4105DT3 PTS system, galactitol-specific IIc component CX649_00230 ENOG4105CPQ Dehydrogenase CX649_00290 ENOG4105CSH Transporter CX649_00295 ENOG4105C5I Dehydrogenase CX649_00305 ENOG4106P55 Transcriptional regulator CX649_00330 ENOG4105DTN riboflavin biosynthesis protein ribF CX649_00335 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CX649_00340 ENOG4105ERH Fumarylacetoacetate hydrolase CX649_00355 ENOG4105C26 Dehydrogenase CX649_00370 ENOG4105C32 Amino acid ABC transporter (Permease) CX649_00375 ENOG4105CF8 branched-chain amino acid ABC transporter, permease CX649_00380 ENOG4105C0Z ABC transporter CX649_00385 ENOG4108IV0 ABC, transporter CX649_00390 ENOG4105FUY alpha subunit CX649_00395 ENOG4108SBK dioxygenase, subunit beta CX649_00440 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CX649_00455 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CX649_00460 ENOG4105C7N Xanthine uracil vitamin C permease CX649_00465 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CX649_00470 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CX649_00475 ENOG4105C83 adenylosuccinate lyase CX649_00480 ENOG4105C8V SAICAR synthetase CX649_00485 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CX649_00490 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CX649_00495 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CX649_00505 ENOG4105CXB phosphoribosylaminoimidazole synthetase CX649_00510 ENOG4108V3E phosphoribosylglycinamide formyltransferase CX649_00515 ENOG4105DC1 bifunctional purine biosynthesis protein purh CX649_00520 ENOG4105C12 Phosphoribosylglycinamide synthetase CX649_00530 ENOG4108R5T secreted protein CX649_00535 ENOG4105KGF protein, YerC YecD CX649_00540 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) CX649_00545 ENOG4105C4R Atp-dependent dna helicase CX649_00550 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CX649_00565 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CX649_00570 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CX649_00575 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CX649_00580 ENOG4105CBD Diacylglycerol kinase CX649_00590 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CX649_00610 ENOG4105CVR type I restriction-modification system CX649_00620 ENOG4107SCJ type I restriction enzyme EcoKI subunit R CX649_00640 ENOG4105E5H Transposase CX649_00680 ENOG4107STQ Multicopper oxidase CX649_00705 ENOG4105E5H Transposase CX649_00745 ENOG4105DZR Type I site-specific deoxyribonuclease CX649_00770 ENOG4108M21 CX649_00780 ENOG4105MUZ Protein of unknown function DUF2620 CX649_00785 ENOG4106M0N transport system permease protein CX649_00790 ENOG41080QX K07048 phosphotriesterase-related protein CX649_00795 ENOG4106PKC pyridoxal phosphate binding CX649_00800 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CX649_00805 ENOG4108626 Racemase CX649_00810 ENOG4108X4Q Hydrolase CX649_00815 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CX649_00840 ENOG4105CRW Short chain fatty acid transporter CX649_00845 ENOG4105CMU LysR family (Transcriptional regulator CX649_00855 ENOG4105CSH Transporter CX649_00865 ENOG41067SE Tetr family transcriptional regulator CX649_00870 ENOG4105DWT malate dehydrogenase (quinone) CX649_00875 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) CX649_00880 ENOG4105DCF alanine dehydrogenase CX649_00885 ENOG4108K8K Transcriptional regulator CX649_00895 ENOG4105CDA abc transporter atp-binding protein CX649_00905 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) CX649_00925 ENOG4105KFN sortase, SrtB family CX649_00930 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CX649_00935 ENOG4105S6R Iron-hydroxamate transporter permease subunit CX649_00955 ENOG4105CDA abc transporter atp-binding protein CX649_00960 ENOG4105E5Q amino acid AbC transporter CX649_00965 ENOG4105EAB amino acid AbC transporter CX649_00970 ENOG41060BG Tetr family transcriptional regulator CX649_00985 ENOG4105FB9 CRISPR-associated protein CX649_01005 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) CX649_01010 ENOG4105KCF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) CX649_01015 ENOG4105C8Q Methyl-accepting chemotaxis CX649_01030 ENOG4105NCW Trka-c domain protein CX649_01035 ENOG4107S91 Sodium hydrogen exchanger CX649_01055 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CX649_01060 ENOG4105F38 ABC transporter, permease CX649_01065 ENOG4105D38 putrescine abc transporter CX649_01070 ENOG4107RUE extracellular solute-binding protein family 1 CX649_01090 ENOG4105BZ1 (ABC) transporter CX649_01095 ENOG4105BZ1 (ABC) transporter CX649_01100 ENOG410667J hydrolase CX649_01105 ENOG4108Z1Z gCN5-related N-acetyltransferase CX649_01110 ENOG4105DHS permease protein CX649_01115 ENOG4105CM4 permease protein CX649_01120 ENOG4108IPW abc transporter atp-binding protein CX649_01140 ENOG4105EXQ uroporphyrinogen iii synthase hem4 CX649_01155 ENOG4108IJ9 (ABC) transporter CX649_01160 ENOG4105DRS transport system, permease CX649_01165 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component CX649_01170 ENOG4108IJG ABC transporter substrate-binding protein CX649_01175 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CX649_01180 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CX649_01195 ENOG4105KVH Transcriptional regulator CX649_01205 ENOG4105C1G acyl-Coa dehydrogenase CX649_01230 ENOG4105ES4 Nitrilase CX649_01235 ENOG4105DTQ mandelate racemase muconate lactonizing CX649_01265 ENOG41068PA UPF0435 protein CX649_01270 ENOG4105KJF protein tyrosine phosphatase CX649_01280 ENOG4107U9T Pfam:Ribonuclease_BN CX649_01300 ENOG4105ECB domain protein CX649_01315 ENOG4105UPD Calcium Proton CX649_01330 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate CX649_01335 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) CX649_01340 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CX649_01345 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CX649_01350 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CX649_01355 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CX649_01360 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CX649_01385 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CX649_01450 ENOG4105D2S major facilitator superfamily CX649_01470 ENOG4107TXC Transcriptional regulator CX649_01475 ENOG4105DQ6 Transposase CX649_01490 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CX649_01505 ENOG4105C28 cystathionine CX649_01510 ENOG4105KAC Antibiotic biosynthesis monooxygenase CX649_01525 ENOG4105F27 Major Facilitator CX649_01530 ENOG4105CSV Glutaminase CX649_01540 ENOG4105C0H protease CX649_01545 ENOG4105DJB Major Facilitator Superfamily CX649_01555 ENOG4107RSM transcriptional regulator CX649_01560 ENOG4108ZCF integral membrane protein CX649_01585 ENOG410902V Modulates RecA activity (By similarity) CX649_01610 ENOG4107VRP DNA repair exonuclease CX649_01615 ENOG4106D4I domain protein CX649_01620 ENOG4105EQI Metal Dependent Phosphohydrolase CX649_01630 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CX649_01665 ENOG4105NBU tryptophan transport protein CX649_01670 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CX649_01675 ENOG4105K59 histidine triad (HIT) protein CX649_01690 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CX649_01695 ENOG4105BZ4 penicillin-binding protein CX649_01700 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CX649_01705 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CX649_01710 ENOG4105C1Q protoporphyrinogen oxidase CX649_01720 ENOG4106AXD CX649_01725 ENOG4108RQ5 Beta-lactamase domain-containing protein CX649_01735 ENOG4105C7J ABC transporter, permease CX649_01745 ENOG4108JCI Transcriptional regulator CX649_01750 ENOG4108UMN azlc family CX649_01760 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CX649_01770 ENOG4105DFU Cell wall formation (By similarity) CX649_01775 ENOG4105C88 aminopeptidase CX649_01790 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CX649_01795 ENOG4105ETE Transcriptional regulator (LacI family CX649_01800 ENOG4105DGU Histone deacetylase CX649_01805 ENOG4105W87 Cbs domain CX649_01810 ENOG4105F1V Acetoin utilization protein CX649_01885 ENOG4105DFF Rod shape-determining protein mreb CX649_01890 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CX649_01905 ENOG4105E7W lamb ycsf family protein CX649_01910 ENOG4105P4J Allophanate hydrolase, subunit 1 CX649_01915 ENOG4107TCE N-acetyltransferase CX649_01920 ENOG4105FRN stage II sporulation protein CX649_01935 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CX649_01945 ENOG4106778 Protein of unknown function (DUF1146) CX649_01950 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CX649_01955 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CX649_01960 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CX649_01965 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CX649_01970 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CX649_01975 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) CX649_01980 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CX649_01985 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) CX649_01990 ENOG41062M3 atp synthase CX649_02000 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CX649_02005 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CX649_02010 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CX649_02020 ENOG4108YZG isomerase CX649_02025 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CX649_02030 ENOG4107WAU Protein tyrosine phosphatase CX649_02035 ENOG410815N Probably functions as a manganese efflux pump (By similarity) CX649_02040 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CX649_02050 ENOG4108ZXQ stage ii sporulation protein r CX649_02055 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CX649_02060 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CX649_02075 ENOG4107104 thymidine kinase CX649_02080 ENOG41082DI 50s ribosomal protein l31 CX649_02085 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CX649_02090 ENOG4105CBT Fructose-1,6-bisphosphatase CX649_02095 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CX649_02100 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CX649_02105 ENOG4105D2N Aldolase CX649_02110 ENOG410812K response regulator receiver protein CX649_02125 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CX649_02135 ENOG4105DF6 Fe-S oxidoreductase CX649_02140 ENOG4105EMN RNA polymerase sigma factor CX649_02145 ENOG4105C75 arginyL-tRNA synthetase CX649_02150 ENOG410684U Domain of unknown function (DUF1934) CX649_02155 ENOG4105CYW agmatinase CX649_02160 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CX649_02165 ENOG4105BZ4 penicillin-binding protein CX649_02170 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CX649_02175 ENOG4108QCI YvbH-like oligomerisation region CX649_02180 ENOG4108VCI transcription factor, rsfa family CX649_02185 ENOG4105QAT UPF0741 protein CX649_02190 ENOG4105DCI Phosphohydrolase CX649_02200 ENOG4108Z4T Peptidase M50 CX649_02205 ENOG4108XFG YwhD family CX649_02210 ENOG4108IJ2 phosphate acetyltransferase CX649_02215 ENOG4107JTW chlorite dismutase CX649_02225 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) CX649_02230 ENOG4108VKI Cell wall hydrolase CX649_02245 ENOG4105EEM helicase CX649_02255 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CX649_02260 ENOG4105DAA L-lactate CX649_02320 ENOG4105DZR Type I site-specific deoxyribonuclease CX649_02325 ENOG4105EKX Restriction modification system DNA (Specificity CX649_02330 ENOG4105CVR type I restriction-modification system CX649_02355 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) CX649_02365 ENOG4105C0H protease CX649_02370 ENOG4105Q2H domain protein CX649_02385 ENOG4105BZU Histidine kinase CX649_02390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CX649_02405 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CX649_02410 ENOG4105CDU Replicative dna helicase CX649_02415 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CX649_02420 ENOG4105BZR domain protein CX649_02425 ENOG4108XMW Membrane CX649_02430 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CX649_02435 ENOG4108UUM single-stranded DNA-binding protein CX649_02440 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CX649_02445 ENOG4105C3G gtp-binding protein CX649_02450 ENOG4105VDK protein, conserved in bacteria CX649_02455 ENOG4108ZDA Sporulation protein YyaC CX649_02460 ENOG4105FA0 parb-like partition protein CX649_02465 ENOG4107QJE Chromosome Partitioning Protein CX649_02470 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) CX649_02475 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CX649_02480 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CX649_02485 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CX649_02490 ENOG4108Z7S Single-stranded nucleic acid binding R3H domain-containing protein CX649_02495 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CX649_02500 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CX649_02505 ENOG4105VG0 50S ribosomal protein l34 CX649_02510 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CX649_02520 ENOG4105D03 DNA-3-methyladenine glycosylase II CX649_02540 ENOG4105KT7 mgtC SapB transporter CX649_02550 ENOG4108Z0C Uvrb UvrC protein CX649_02555 ENOG41066A3 ATP guanido phosphotransferase CX649_02565 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CX649_02570 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) CX649_02575 ENOG4105CTP PilT protein domain protein CX649_02580 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CX649_02585 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CX649_02590 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CX649_02595 ENOG4105D7W serine acetyltransferase CX649_02600 ENOG4105C8N cysteinyl-tRNA synthetase CX649_02605 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) CX649_02610 ENOG4105C2N RNA methyltransferase TrmH family group 3 CX649_02615 ENOG4105M0M Tetracycline resistance protein CX649_02620 ENOG4105QIV RNA polymerase CX649_02635 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CX649_02645 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CX649_02650 ENOG4108VZM 50s ribosomal protein L10 CX649_02655 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CX649_02660 ENOG4107Y49 methyltransferase CX649_02665 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CX649_02670 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CX649_02675 ENOG4105XPM ribosomal protein CX649_02680 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CX649_02685 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CX649_02690 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CX649_02695 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CX649_02700 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CX649_02705 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CX649_02710 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CX649_02715 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CX649_02720 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CX649_02725 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CX649_02730 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CX649_02735 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CX649_02740 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CX649_02745 ENOG41082SA 50s ribosomal protein l29 CX649_02750 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CX649_02755 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CX649_02760 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CX649_02765 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CX649_02770 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CX649_02775 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CX649_02780 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CX649_02785 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CX649_02790 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CX649_02800 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CX649_02805 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CX649_02810 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CX649_02815 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CX649_02825 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CX649_02835 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CX649_02840 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CX649_02850 ENOG4108ZT0 50S ribosomal protein l17 CX649_02855 ENOG4108JJB ABC transporter CX649_02860 ENOG4108JJB ABC transporter CX649_02865 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CX649_02870 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CX649_02875 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CX649_02880 ENOG4108UJD 30S ribosomal protein S9 CX649_02905 ENOG4105D1F ATP-binding protein CX649_02920 ENOG4108NMV polysaccharide deacetylase CX649_02935 ENOG4108UMI ABC transporter, permease CX649_02940 ENOG4105D01 (LipO)protein CX649_02950 ENOG4105CPC Aldo Keto reductase CX649_02955 ENOG4108KC1 acyl-Coa dehydrogenase CX649_02960 ENOG4105C1G acyl-Coa dehydrogenase CX649_02965 ENOG4105DEN Luciferase family CX649_02970 ENOG4105NBF ammecr1 domain protein CX649_02985 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) CX649_03005 ENOG41069M3 Transcriptional regulator CX649_03015 ENOG4105ECY inositol monophosphatase CX649_03020 ENOG41073TP transcriptional regulator CX649_03025 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CX649_03030 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CX649_03050 ENOG4105DRP amino acid AbC transporter CX649_03055 ENOG4105EAD ABC transporter CX649_03090 ENOG4107RKG DJ-1/PfpI family CX649_03100 ENOG4105DEN Luciferase family CX649_03110 ENOG4105DJ2 Major Facilitator Superfamily CX649_03120 ENOG4107WD8 ABC transporter, permease CX649_03125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CX649_03130 ENOG4105BZU Histidine kinase CX649_03135 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CX649_03140 ENOG4108Q5U germination protein, ger(x)c family CX649_03150 ENOG4105CBC glutamate synthase CX649_03160 ENOG4105CM2 brancheD-chain amino acid aminotransferase CX649_03165 ENOG4105U0R haloacid dehalogenase-like hydrolase CX649_03170 ENOG4105SZ6 Thioredoxin CX649_03175 ENOG4105CPF Cell wall formation (By similarity) CX649_03180 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CX649_03185 ENOG4105D7V transposase CX649_03190 ENOG4105C1J atp-dependent rna helicase CX649_03195 ENOG410905X membrane-flanked domain protein CX649_03200 ENOG4105CKV Membrane CX649_03210 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CX649_03215 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CX649_03230 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CX649_03235 ENOG4107MMM Anti-sigma-factor antagonist CX649_03240 ENOG4105FUA antagonist CX649_03245 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase CX649_03250 ENOG4107SGM protein serine threonine phosphatase CX649_03255 ENOG4105WN5 stage II sporulation protein CX649_03260 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CX649_03270 ENOG41064BQ Phosphatase CX649_03355 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CX649_03360 ENOG4105K4P CoA-binding domain protein CX649_03365 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CX649_03370 ENOG4105DVT helicase CX649_03390 ENOG4105W8X HesB YadR YfhF-family protein CX649_03395 ENOG4105MI2 CX649_03420 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CX649_03425 ENOG4108I0Z Aconitate hydratase CX649_03455 ENOG4107YTP response regulator receiver protein CX649_03460 ENOG4107QIV Cytochrome c biogenesis protein CX649_03465 ENOG4105VXM UPF0154 protein CX649_03480 ENOG4105VPS UPF0291 protein CX649_03485 ENOG4108SVB resolvase CX649_03495 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CX649_03500 ENOG4105D82 Glutamate dehydrogenase CX649_03505 ENOG4105F6E Acyl-transferase CX649_03510 ENOG4108URH decarboxylase CX649_03515 ENOG4107SET aldo keto reductase CX649_03520 ENOG4105FBA Phospholipase Carboxylesterase CX649_03525 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CX649_03555 ENOG4105ENE Histidine kinase CX649_03560 ENOG4105WH1 Two component transcriptional regulator luxr family CX649_03570 ENOG4105C8Q Methyl-accepting chemotaxis CX649_03575 ENOG4105BZU Histidine kinase CX649_03605 ENOG4108KK1 membrane protein AbrB duplication CX649_03610 ENOG4108KAM Transcriptional regulator CX649_03630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CX649_03635 ENOG4105BZU Histidine kinase CX649_03660 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CX649_03665 ENOG4105E39 Enoyl-CoA hydratase CX649_03685 ENOG4105EHG Permease protein CX649_03690 ENOG4105DQ5 transport system permease protein CX649_03725 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CX649_03730 ENOG4105K4P CoA-binding domain protein CX649_03735 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CX649_03740 ENOG4105DVT helicase CX649_03760 ENOG4105W8X HesB YadR YfhF-family protein CX649_03765 ENOG4105MI2 CX649_03790 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CX649_03795 ENOG4108I0Z Aconitate hydratase CX649_03825 ENOG4107YTP response regulator receiver protein CX649_03830 ENOG4107QIV Cytochrome c biogenesis protein CX649_03835 ENOG4105VXM UPF0154 protein CX649_03850 ENOG4105VPS UPF0291 protein CX649_03855 ENOG4108SVB resolvase CX649_03865 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CX649_03870 ENOG4105D82 Glutamate dehydrogenase CX649_03875 ENOG4105F6E Acyl-transferase CX649_03880 ENOG4108URH decarboxylase CX649_03885 ENOG4107SET aldo keto reductase CX649_03890 ENOG4105FBA Phospholipase Carboxylesterase CX649_03895 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CX649_03925 ENOG4105ENE Histidine kinase CX649_03930 ENOG4105WH1 Two component transcriptional regulator luxr family CX649_03940 ENOG4105C8Q Methyl-accepting chemotaxis CX649_03945 ENOG4105BZU Histidine kinase CX649_03975 ENOG4108KK1 membrane protein AbrB duplication CX649_03980 ENOG4108KAM Transcriptional regulator CX649_04000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CX649_04005 ENOG4105BZU Histidine kinase CX649_04030 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CX649_04035 ENOG4105E39 Enoyl-CoA hydratase CX649_04055 ENOG4105EHG Permease protein CX649_04060 ENOG4105DQ5 transport system permease protein CX649_04115 ENOG4107TRE AP endonuclease, family 2 CX649_04120 ENOG4105D0M Protease HtpX homolog CX649_04165 ENOG4105C26 Dehydrogenase CX649_04170 ENOG4105DH8 myo-inositol catabolism CX649_04175 ENOG4105EDK PfkB domain protein CX649_04180 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) CX649_04185 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CX649_04195 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CX649_04200 ENOG4105C2J ABC transporter CX649_04205 ENOG4105CNN ABC, transporter CX649_04210 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CX649_04215 ENOG4105CK5 oxidoreductase CX649_04220 ENOG4105D2N Aldolase CX649_04235 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CX649_04240 ENOG4105CQB FAD linked oxidase domain protein CX649_04245 ENOG4105JXH GntR family transcriptional regulator CX649_04265 ENOG4105C45 hydrogenase expression formation protein (HypE) CX649_04270 ENOG4105CQS hydrogenase expression formation protein HypD CX649_04310 ENOG4105DPX Hydrogenase, large subunit CX649_04325 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CX649_04340 ENOG4108X79 transcriptional regulator CX649_04365 ENOG4105ENV phosphonate C-P lyase system protein PhnK CX649_04370 ENOG4105FD8 phosphonate metabolism protein PhnM CX649_04380 ENOG4105HRV phosphonate c-p lyase system protein phnl CX649_04390 ENOG4105D5T phosphonate abc transporter CX649_04400 ENOG4105S7S phosphonate abc transporter CX649_04405 ENOG4105DB7 PHP domain protein CX649_04415 ENOG4105DA5 (ABC) transporter CX649_04440 ENOG4105CV2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) CX649_04450 ENOG4105E0C molybdate abc transporter CX649_04455 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CX649_04465 ENOG4107QKR Dehydrogenase CX649_04470 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CX649_04475 ENOG4105CVM Molybdenum cofactor synthesis domain protein CX649_04485 ENOG4105DSE periplasmic solute binding protein CX649_04490 ENOG4105DIK (ABC) transporter CX649_04495 ENOG4105CC5 ABC transporter CX649_04500 ENOG4105CC5 ABC transporter CX649_04505 ENOG4105KST dependent repressor CX649_04525 ENOG4105BZ4 penicillin-binding protein CX649_04540 ENOG4105VFR signal peptidase CX649_04585 ENOG410787A Pts system, glucitol sorbitol-specific CX649_04590 ENOG4105DZY Pts system, glucitol sorbitol-specific CX649_04595 ENOG4105VI0 Pts system, glucitol sorbitol-specific CX649_04600 ENOG4107RHR regulatoR CX649_04605 ENOG4107RUY (E1 component), alpha subunit CX649_04610 ENOG4105CPP Dehydrogenase, E1 component CX649_04615 ENOG4105C7S Dehydrogenase CX649_04625 ENOG4107RHR regulatoR CX649_04630 ENOG41082GB PTS system galactitol-specific transporter subunit IIA CX649_04635 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) CX649_04640 ENOG4105DT3 PTS system, galactitol-specific IIc component CX649_04645 ENOG4108MRH transcriptional regulatory protein CX649_04650 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CX649_04655 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CX649_04660 ENOG4107QJT sodium dicarboxylate symporter CX649_04665 ENOG4105DG6 mannose-6-phosphate isomerase CX649_04680 ENOG4108KGH TRANSCRIPTIONal CX649_04690 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CX649_04710 ENOG4105CKK Glycosyl transferase, family 2 CX649_04720 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) CX649_04735 ENOG4105CJR Integral membrane protein (MviN CX649_04745 ENOG4105JNK Glycosyl transferase (Group 1 CX649_04750 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CX649_04755 ENOG4105ESV Glycosyl transferase, family 4 CX649_04760 ENOG4108KGH TRANSCRIPTIONal CX649_04765 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CX649_04770 ENOG4105BZU Histidine kinase CX649_04775 ENOG4105WH1 Two component transcriptional regulator luxr family CX649_04795 ENOG4107S6X Glycosyl transferase, family 2 CX649_04810 ENOG4107TY6 Acylneuraminate cytidylyltransferase CX649_04815 ENOG4105EQQ protein containing aminopeptidase domain CX649_04820 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) CX649_04830 ENOG4105D2T synthase CX649_04835 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CX649_04885 ENOG41067SE Tetr family transcriptional regulator CX649_04890 ENOG41069ER domain protein CX649_04900 ENOG4106I4J membrane CX649_04915 ENOG4105C26 Dehydrogenase CX649_04925 ENOG4105D94 Major Facilitator Superfamily CX649_04940 ENOG4105CID antiterminator CX649_04945 ENOG4105CS2 ec 3.2.1.21 CX649_04950 ENOG4105CS2 ec 3.2.1.21 CX649_04955 ENOG4105C5Y PTS System CX649_04960 ENOG4107Z6I Thiamine biosynthesis protein CX649_04965 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CX649_04975 ENOG4105EC8 Methyl-accepting chemotaxis CX649_04985 ENOG4105EIG urea carboxylase-associated protein 1 CX649_04990 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CX649_05020 ENOG4108IUX (ABC) transporter CX649_05025 ENOG4105RHA ABC transporter, permease CX649_05030 ENOG4105C8Q Methyl-accepting chemotaxis CX649_05040 ENOG4105E98 transcriptional regulator DeoR family CX649_05045 ENOG4105NWF RbsD or FucU transport CX649_05050 ENOG4105CMG Carbohydrate kinase CX649_05055 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CX649_05060 ENOG4105C2J ABC transporter CX649_05065 ENOG4105CNN ABC, transporter CX649_05070 ENOG4108QGH periplasmic CX649_05075 ENOG4107W7X Aldolase CX649_05080 ENOG4105DET Rhamnulokinase CX649_05090 ENOG4105EF1 ribulokinase CX649_05100 ENOG4108IIH CoA-transferase subunit B CX649_05105 ENOG4105D6N CoA-transferase, subunit a CX649_05110 ENOG4105CMU LysR family (Transcriptional regulator CX649_05115 ENOG4107RID 5-oxoprolinase (ATP-hydrolyzing) CX649_05120 ENOG4107TYC hydantoinase B oxoprolinase CX649_05125 ENOG4105HKX acetone carboxylase, gamma subunit CX649_05150 ENOG4108UVJ appr-1-p processing domain protein CX649_05155 ENOG4108VEN abc transporter atp-binding protein CX649_05160 ENOG4108Z66 YbaK ebsC protein CX649_05175 ENOG4105X1N Glycosyl transferase family 8 CX649_05180 ENOG4105G9B Transcriptional regulator CX649_05185 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CX649_05190 ENOG4105E39 Enoyl-CoA hydratase CX649_05195 ENOG4105CEY Amp-dependent synthetase and ligase CX649_05205 ENOG4105C1G acyl-Coa dehydrogenase CX649_05230 ENOG4105DZS Phenylacetate-CoA ligase CX649_05245 ENOG4105ERH Fumarylacetoacetate hydrolase CX649_05265 ENOG41083S7 flagellar protein FlaG CX649_05270 ENOG4107RT6 flagellar hook-associated CX649_05275 ENOG4105MQ3 flagellar protein FliS CX649_05285 ENOG4105MS2 ribosomal subunit Interface protein CX649_05290 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CX649_05305 ENOG4105CAK Cell division ATP-binding protein ftsE CX649_05310 ENOG4105CRP Part of the ABC transporter FtsEX involved in CX649_05315 ENOG4105DR5 peptidase CX649_05320 ENOG4105CN1 protease CX649_05325 ENOG4105DZS Phenylacetate-CoA ligase CX649_05340 ENOG4105ERH Fumarylacetoacetate hydrolase CX649_05360 ENOG41083S7 flagellar protein FlaG CX649_05365 ENOG4107RT6 flagellar hook-associated CX649_05370 ENOG4105MQ3 flagellar protein FliS CX649_05380 ENOG4105MS2 ribosomal subunit Interface protein CX649_05385 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CX649_05400 ENOG4105CAK Cell division ATP-binding protein ftsE CX649_05405 ENOG4105CRP Part of the ABC transporter FtsEX involved in CX649_05410 ENOG4105DR5 peptidase CX649_05415 ENOG4105CN1 protease CX649_05420 ENOG4105DZS Phenylacetate-CoA ligase CX649_05435 ENOG4105ERH Fumarylacetoacetate hydrolase CX649_05455 ENOG41083S7 flagellar protein FlaG CX649_05460 ENOG4107RT6 flagellar hook-associated CX649_05465 ENOG4105MQ3 flagellar protein FliS CX649_05475 ENOG4105MS2 ribosomal subunit Interface protein CX649_05480 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CX649_05495 ENOG4105CAK Cell division ATP-binding protein ftsE CX649_05500 ENOG4105CRP Part of the ABC transporter FtsEX involved in CX649_05505 ENOG4105DR5 peptidase CX649_05510 ENOG4105CN1 protease CX649_05515 ENOG4105DZS Phenylacetate-CoA ligase CX649_05530 ENOG4105ERH Fumarylacetoacetate hydrolase CX649_05550 ENOG41083S7 flagellar protein FlaG CX649_05555 ENOG4107RT6 flagellar hook-associated CX649_05560 ENOG4105MQ3 flagellar protein FliS CX649_05570 ENOG4105MS2 ribosomal subunit Interface protein CX649_05575 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CX649_05590 ENOG4105CAK Cell division ATP-binding protein ftsE CX649_05595 ENOG4105CRP Part of the ABC transporter FtsEX involved in CX649_05600 ENOG4105DR5 peptidase CX649_05605 ENOG4105CN1 protease CX649_05610 ENOG4105DZS Phenylacetate-CoA ligase CX649_05625 ENOG4105ERH Fumarylacetoacetate hydrolase CX649_05645 ENOG41083S7 flagellar protein FlaG CX649_05650 ENOG4107RT6 flagellar hook-associated CX649_05655 ENOG4105MQ3 flagellar protein FliS CX649_05665 ENOG4105MS2 ribosomal subunit Interface protein CX649_05670 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CX649_05685 ENOG4105CAK Cell division ATP-binding protein ftsE CX649_05690 ENOG4105CRP Part of the ABC transporter FtsEX involved in CX649_05695 ENOG4105DR5 peptidase CX649_05700 ENOG4105CN1 protease CX649_05705 ENOG4105DZS Phenylacetate-CoA ligase CX649_05720 ENOG4105ERH Fumarylacetoacetate hydrolase CX649_05740 ENOG41083S7 flagellar protein FlaG CX649_05745 ENOG4107RT6 flagellar hook-associated CX649_05750 ENOG4105MQ3 flagellar protein FliS CX649_05760 ENOG4105MS2 ribosomal subunit Interface protein CX649_05765 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CX649_05780 ENOG4105CAK Cell division ATP-binding protein ftsE CX649_05785 ENOG4105CRP Part of the ABC transporter FtsEX involved in CX649_05790 ENOG4105DR5 peptidase CX649_05795 ENOG4105CN1 protease CX649_05800 ENOG4105DZS Phenylacetate-CoA ligase CX649_05815 ENOG4105ERH Fumarylacetoacetate hydrolase CX649_05835 ENOG41083S7 flagellar protein FlaG CX649_05840 ENOG4107RT6 flagellar hook-associated CX649_05845 ENOG4105MQ3 flagellar protein FliS CX649_05855 ENOG4105MS2 ribosomal subunit Interface protein CX649_05860 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CX649_05875 ENOG4105CAK Cell division ATP-binding protein ftsE CX649_05880 ENOG4105CRP Part of the ABC transporter FtsEX involved in CX649_05885 ENOG4105DR5 peptidase CX649_05890 ENOG4105CN1 protease CX649_05895 ENOG4105DZS Phenylacetate-CoA ligase CX649_05910 ENOG4105ERH Fumarylacetoacetate hydrolase CX649_05930 ENOG41083S7 flagellar protein FlaG CX649_05935 ENOG4107RT6 flagellar hook-associated CX649_05940 ENOG4105MQ3 flagellar protein FliS CX649_05950 ENOG4105MS2 ribosomal subunit Interface protein CX649_05955 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CX649_05970 ENOG4105CAK Cell division ATP-binding protein ftsE CX649_05975 ENOG4105CRP Part of the ABC transporter FtsEX involved in CX649_05980 ENOG4105DR5 peptidase CX649_05985 ENOG4105CN1 protease CX649_06000 ENOG41086DT Membrane protein of unknown function CX649_06005 ENOG41088CQ domain protein CX649_06010 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) CX649_06020 ENOG4105HKU nucleoside recognition domain-containing protein CX649_06025 ENOG4107XGZ Hydrolase CX649_06030 ENOG4108S4C acetyltransferase CX649_06035 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) CX649_06040 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CX649_06045 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CX649_06050 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CX649_06055 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CX649_06060 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CX649_06065 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CX649_06070 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CX649_06080 ENOG4105C3M thioredoxin reductase CX649_06085 ENOG4108Z4K mutator MutT protein CX649_06090 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CX649_06095 ENOG4105CHW UPF0052 protein CX649_06100 ENOG4105CIE May be required for sporulation (By similarity) CX649_06105 ENOG4105KRI phosphocarrier protein (HPr CX649_06110 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CX649_06130 ENOG4105DY9 regulatoR CX649_06135 ENOG4105CYC Transferase CX649_06140 ENOG4105BZW Glycerate kinase CX649_06150 ENOG4105F8D glycoside hydrolase family 4 CX649_06170 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) CX649_06175 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) CX649_06215 ENOG4105CIY formyltetrahydrofolate deformylase CX649_06220 ENOG4105V75 Transcriptional regulator CX649_06225 ENOG4105C9Q fumarate hydratase class II CX649_06235 ENOG4108MES Periplasmic binding protein CX649_06240 ENOG4105DQ5 transport system permease protein CX649_06245 ENOG4108IHU transport system permease protein CX649_06250 ENOG4105E0A ABC, transporter CX649_06280 ENOG4105CHU acetyl-coa acetyltransferase CX649_06285 ENOG4105C1G acyl-Coa dehydrogenase CX649_06290 ENOG41080E8 Transcriptional regulator, Spx MgsR family CX649_06295 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CX649_06315 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CX649_06320 ENOG4108UMI ABC transporter, permease CX649_06325 ENOG4105D01 (LipO)protein CX649_06340 ENOG4105C3K feS assembly ATPase SufC CX649_06345 ENOG4105JRK feS assembly protein SufD CX649_06350 ENOG4105C9B Cysteine desulfurase CX649_06355 ENOG4108UNV SUF system FeS assembly protein, NifU family CX649_06360 ENOG4105DIW FeS assembly protein SUFB CX649_06375 ENOG4105I3N Conserved Protein CX649_06380 ENOG4107R8B 5'-nucleotidase CX649_06385 ENOG4105KZD Domain of unknown function (DUF1805) CX649_06390 ENOG4105FAA peptidase M23 CX649_06395 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CX649_06400 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CX649_06405 ENOG4105MMD transcriptional regulator CX649_06425 ENOG4105D4U had-superfamily hydrolase, subfamily iia CX649_06430 ENOG4108W5N phosphatidylglycerophosphatase a CX649_06440 ENOG4105C5I Dehydrogenase CX649_06445 ENOG4105D6E homoserine dehydrogenase CX649_06450 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) CX649_06455 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CX649_06460 ENOG41083MR nifu domain-containing protein CX649_06485 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CX649_06490 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CX649_06495 ENOG4105CAY ferredoxin--nadp reductase CX649_06500 ENOG4105CEP NADH dehydrogenase CX649_06530 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CX649_06540 ENOG4108NKM UPF0354 protein CX649_06555 ENOG4107QP3 malate synthase g CX649_06570 ENOG4105XVF Competence transcription factor CX649_06595 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CX649_06605 ENOG4105EYH Exonuclease CX649_06640 ENOG4107YXA Transcriptional regulator, BadM Rrf2 family CX649_06650 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CX649_06655 ENOG4108I5D sulfate abc transporter CX649_06660 ENOG4105ECW sulfate abc transporter CX649_06670 ENOG4105GVF (ABC) transporter CX649_06675 ENOG4105FBW Monooxygenase CX649_06680 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CX649_06685 ENOG4105E2Y ABC, transporter CX649_06700 ENOG4108RE7 deoxyribonuclease CX649_06705 ENOG4105ERH Fumarylacetoacetate hydrolase CX649_06720 ENOG4105CAQ asparagine synthetase CX649_06735 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CX649_06740 ENOG41088CQ domain protein CX649_06770 ENOG4105BZ1 (ABC) transporter CX649_06780 ENOG4108IUW ABC transporter CX649_06800 ENOG4108VPT UPF0234 protein CX649_06815 ENOG4105EPR degv family CX649_06825 ENOG4108KP7 hydrolase CX649_06830 ENOG4108MXZ Esterase CX649_06835 ENOG4105VG1 fes assembly suf system protein CX649_06840 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CX649_06845 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) CX649_06860 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CX649_06870 ENOG4105DBV ornithine carbamoyltransferase CX649_06880 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CX649_06900 ENOG4107RMD Basic membrane lipoprotein CX649_06910 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CX649_06915 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CX649_06960 ENOG4105C0K Gdp-mannose 4,6-dehydratase CX649_06970 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CX649_07005 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase CX649_07015 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CX649_07070 ENOG4105H67 Protein of unknown function (DUF421) CX649_07080 ENOG4108ZMI UPF0477 protein CX649_07100 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein CX649_07105 ENOG4105C28 cystathionine CX649_07110 ENOG4105C28 cystathionine CX649_07170 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CX649_07175 ENOG4107XVH Transcriptional regulator CX649_07180 ENOG4105XRQ Xanthine dehydrogenase accessory factor CX649_07210 ENOG4105E39 Enoyl-CoA hydratase CX649_07215 ENOG4105CSH Transporter CX649_07250 ENOG4105C5Y PTS System CX649_07255 ENOG4105CG3 alpha amylase, catalytic region CX649_07260 ENOG4107414 GntR family transcriptional regulator CX649_07275 ENOG4105C5Y PTS System CX649_07285 ENOG4105D7K pfkb domain protein CX649_07300 ENOG4107RGD Major Facilitator superfamily CX649_07310 ENOG4105CE7 Amidase, hydantoinase carbamoylase family CX649_07320 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) CX649_07355 ENOG4105CJ1 ABC, transporter CX649_07370 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CX649_07375 ENOG4108IEG Formate dehydrogenase Alpha subunit CX649_07385 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CX649_07405 ENOG4105CZM Major Facilitator CX649_07410 ENOG4105MSY salicylate hydroxylase CX649_07420 ENOG4105J4Q Transcriptional regulator CX649_07425 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit CX649_07435 ENOG4105CG6 trap dicarboxylate transporter dctm subunit CX649_07455 ENOG41082UD thioesterase Superfamily protein CX649_07460 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CX649_07470 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CX649_07490 ENOG4107258 Transcriptional regulator CX649_07495 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CX649_07505 ENOG4105CBC glutamate synthase CX649_07520 ENOG4105BZU Histidine kinase CX649_07525 ENOG4105C1G acyl-Coa dehydrogenase CX649_07540 ENOG4105E3J oxidoreductase CX649_07565 ENOG4108SJC Membrane CX649_07570 ENOG4107YZX Universal stress protein CX649_07580 ENOG4108ZJ4 polysaccharide deacetylase CX649_07585 ENOG4105C3M thioredoxin reductase CX649_07610 ENOG4105F6S Spore photoproduct lyase CX649_07625 ENOG4105F0V Cell wall hydrolase CX649_07640 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CX649_07645 ENOG4105EHG Permease protein CX649_07650 ENOG4105E0A ABC, transporter CX649_07655 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CX649_07660 ENOG4107QZB decarboxylase CX649_07665 ENOG4108YZT Adenosylcobinamide kinase CX649_07670 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CX649_07675 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) CX649_07705 ENOG4105C37 (CBS) domain CX649_07710 ENOG4105EVH UPF0753 protein CX649_07715 ENOG4108TWJ NADH dehydrogenase subunit 5 CX649_07720 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CX649_07725 ENOG4105CFH Aspartokinase CX649_07730 ENOG4105C8Q Methyl-accepting chemotaxis CX649_07745 ENOG4105ETU transcriptional activator (TenA CX649_07750 ENOG4105ETU transcriptional activator (TenA CX649_07760 ENOG4108JJB ABC transporter CX649_07770 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein CX649_07775 ENOG4105C32 Amino acid ABC transporter (Permease) CX649_07785 ENOG4105C0Z ABC transporter CX649_07790 ENOG4108IV0 ABC, transporter CX649_07795 ENOG4108YZ9 Urea amidohydrolase subunit gamma CX649_07800 ENOG4105KI2 Urea amidohydrolase subunit beta CX649_07810 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) CX649_07845 ENOG4105DKW ABC transporter CX649_07850 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CX649_07880 ENOG4105DZC cytosine deaminase CX649_07885 ENOG4105CS1 NAD(P)H quinone oxidoreductase CX649_07890 ENOG4105XRQ Xanthine dehydrogenase accessory factor CX649_07905 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding CX649_07910 ENOG4107YV9 domain protein CX649_07935 ENOG4105FDT acyl-CoA dehydrogenase CX649_07940 ENOG4105EU0 Major facilitator Superfamily CX649_07960 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CX649_07970 ENOG4107ZYR domain protein CX649_07975 ENOG4105CN5 Metallo-Beta-Lactamase CX649_07980 ENOG4106148 UPF0356 protein CX649_07985 ENOG4108X4Q Hydrolase CX649_07990 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CX649_08005 ENOG4105CPP Dehydrogenase, E1 component CX649_08010 ENOG4105C7S Dehydrogenase CX649_08040 ENOG4105CXN decarboxylase CX649_08045 ENOG4105EA8 2-Nitropropane dioxygenase CX649_08055 ENOG4105ECY inositol monophosphatase CX649_08065 ENOG4105CI3 gtp-binding protein typa CX649_08070 ENOG4105QA2 CX649_08085 ENOG4108IAB Phoh family CX649_08100 ENOG4105CNI cell division protein FtsW CX649_08105 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CX649_08110 ENOG410890F Dynamin family CX649_08120 ENOG41081VK Ribonuclease CX649_08140 ENOG4105CVG Homoserine O-transsuccinylase CX649_08145 ENOG4108V06 Glutathione peroxidase CX649_08155 ENOG4108Y6J UPF0403 protein CX649_08170 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CX649_08175 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CX649_08180 ENOG4105C7B Threonine dehydratase CX649_08190 ENOG4108RCR degv family CX649_08195 ENOG4108KF3 Electron transport protein SCO1 SenC CX649_08200 ENOG41090WU lipolytic protein G-D-S-L family CX649_08205 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) CX649_08210 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CX649_08225 ENOG4105E0X reductase CX649_08240 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CX649_08245 ENOG4105VSD UPF0346 protein CX649_08265 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) CX649_08300 ENOG4108YTE sporulation protein YunB CX649_08315 ENOG41090VF Stage v sporulation protein ac CX649_08320 ENOG4105CZ3 stage V sporulation protein ad CX649_08335 ENOG4108QY0 Membrane CX649_08340 ENOG4105C3M thioredoxin reductase CX649_08355 ENOG4105C01 Dihydroxy-acid dehydratase CX649_08370 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CX649_08380 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CX649_08395 ENOG41079KZ Major Facilitator Superfamily CX649_08400 ENOG41067SE Tetr family transcriptional regulator CX649_08430 ENOG4106YBV Methyl-accepting chemotaxis CX649_08455 ENOG4105VPX protein, conserved in bacteria CX649_08465 ENOG41082MP copper ion binding protein CX649_08475 ENOG4105KWG Pfam:DUF1696 CX649_08490 ENOG4105CW7 secretion protein, HlyD family CX649_08495 ENOG4105C0R drug resistance transporter emrb qaca subfamily CX649_08505 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CX649_08510 ENOG4108RPX mosc domain containing protein CX649_08525 ENOG4105CR4 methylisocitrate lyase CX649_08530 ENOG4105DXD 2-methylcitrate dehydratase CX649_08545 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) CX649_08550 ENOG4105CPC Aldo Keto reductase CX649_08560 ENOG4108HRK Histidine kinase CX649_08565 ENOG4108NEV two component transcriptional regulator, LytTR family CX649_08575 ENOG4105PF9 Transcriptional regulator CX649_08585 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CX649_08600 ENOG4105IIP Membrane CX649_08605 ENOG4105W1N transcriptional regulator CX649_08615 ENOG4107ZXU DSBA oxidoreductase CX649_08635 ENOG4105GVJ transcriptional regulator CX649_08640 ENOG4105EYF MMPL domain protein CX649_08645 ENOG4105E39 Enoyl-CoA hydratase CX649_08650 ENOG4107QX3 carboxylase CX649_08655 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) CX649_08660 ENOG4105E0C molybdate abc transporter CX649_08665 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CX649_08670 ENOG4108R96 Methyltransferase, YaeB family CX649_08675 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CX649_08685 ENOG4105E1F short-chain dehydrogenase reductase CX649_08690 ENOG4108HFV CX649_08700 ENOG41082YX Transcriptional regulator, arsr family CX649_08705 ENOG4105D6J arsenicaL-resistance protein CX649_08710 ENOG4108UXE Protein tyrosine phosphatase CX649_08720 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CX649_08725 ENOG4107EPV Aminotransferase class V CX649_08735 ENOG41089UC methyltransferase, type 11 CX649_08745 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CX649_08750 ENOG4105C1G acyl-Coa dehydrogenase CX649_08795 ENOG4105C4B ABC transporter, permease CX649_08800 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CX649_08825 ENOG4108ZAF Molybdopterin CX649_08830 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CX649_08835 ENOG4105CVM Molybdenum cofactor synthesis domain protein CX649_08840 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CX649_08845 ENOG4105EPU Molybdenum cofactor synthesis domain protein CX649_08880 ENOG4105VG1 fes assembly suf system protein CX649_08890 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E CX649_08895 ENOG4107V6Q Cyclic nucleotide-binding domain CX649_08910 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) CX649_08935 ENOG4105C5F glutamine synthetase CX649_08940 ENOG4105KV4 Transcriptional regulator CX649_08950 ENOG4105CXI aluminum resistance protein CX649_08955 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CX649_08960 ENOG4106F1P AAA ATPase, central domain protein CX649_08965 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CX649_08970 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CX649_08975 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CX649_08980 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CX649_08995 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CX649_09055 ENOG4105CNU cell division protein FtsK CX649_09095 ENOG4105DQU oxidoreductase, subunit beta CX649_09100 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein CX649_09105 ENOG4105MCT stage V sporulation protein S CX649_09115 ENOG4105D48 metallophosphoesterase CX649_09120 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) CX649_09125 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CX649_09130 ENOG4105CEV competence damage-inducible protein CX649_09135 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CX649_09150 ENOG4105XZV Protein of unknown function (DUF3243) CX649_09155 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CX649_09180 ENOG4105CNU cell division protein FtsK CX649_09190 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CX649_09200 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CX649_09210 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CX649_09215 ENOG4108S0H Dipicolinic acid synthetase, b subunit CX649_09220 ENOG4105E35 Dipicolinate synthase subunit A CX649_09230 ENOG4105C1V Peptidase, M16 CX649_09240 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CX649_09245 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CX649_09250 ENOG4105DTN riboflavin biosynthesis protein ribF CX649_09255 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CX649_09260 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CX649_09265 ENOG4105W7A Protein of unknown function (DUF503) CX649_09270 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CX649_09275 ENOG4105VHM ribosomal protein CX649_09280 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CX649_09285 ENOG4105CHV Transcription elongation factor NusA CX649_09290 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) CX649_09295 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CX649_09300 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CX649_09305 ENOG4105DZP Membrane-associated zinc metalloprotease CX649_09315 ENOG4105KNE Phosphatidate cytidylyltransferase CX649_09320 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CX649_09325 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CX649_09330 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CX649_09335 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CX649_09340 ENOG4105CE9 30S ribosomal protein S2 CX649_09350 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CX649_09355 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) CX649_09365 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis CX649_09370 ENOG4105CBS Chea signal transduction histidine kinase CX649_09375 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) CX649_09385 ENOG4105FZW flagellar biosynthesis regulator FlhF CX649_09390 ENOG4105D7B Flagellar biosynthesis protein flha CX649_09395 ENOG4105D00 flagellar biosynthetic protein flhB CX649_09400 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CX649_09405 ENOG4105VS8 Flagellar biosynthetic protein fliq CX649_09410 ENOG4105CN7 Flagellar biosynthetic protein FliP CX649_09420 ENOG4107YTP response regulator receiver protein CX649_09425 ENOG4105DD5 Flagellar motor switch protein CX649_09430 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CX649_09440 ENOG41068WV flagellar FlbD family protein CX649_09445 ENOG4108JQA flagellar CX649_09450 ENOG410822I Flagellar hook capping protein CX649_09455 ENOG410696Y Flagellar hook-length control protein CX649_09465 ENOG4106YF4 Flagellar biosynthesis chaperone CX649_09480 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CX649_09485 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CX649_09490 ENOG4105VQ0 flagellar hook-basal body complex protein fliE CX649_09495 ENOG4108ZC9 flagellar basal-body rod protein flgc CX649_09500 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CX649_09505 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) CX649_09510 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CX649_09515 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CX649_09520 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CX649_09525 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) CX649_09530 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CX649_09535 ENOG4105C79 DNA protecting protein DprA CX649_09540 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CX649_09545 ENOG4105CMV Succinyl-CoA synthetase subunit beta CX649_09550 ENOG4105VM1 flagellar CX649_09560 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CX649_09575 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CX649_09585 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CX649_09600 ENOG4105VB6 UPF0109 protein CX649_09605 ENOG4105K5M 30s ribosomal protein S16 CX649_09615 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) CX649_09620 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CX649_09625 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CX649_09630 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CX649_09635 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CX649_09640 ENOG4105CHR reductase CX649_09645 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CX649_09650 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CX649_09655 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) CX649_09660 ENOG4105CB5 ATP-dependent DNA helicase recG CX649_09665 ENOG4105DP4 dak2 domain fusion protein ylov CX649_09670 ENOG4108ZAA Alkaline-shock protein CX649_09675 ENOG4105VB9 50S ribosomal protein l28 CX649_09685 ENOG4105DJV ribulose-phosphate 3-epimerase CX649_09690 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CX649_09695 ENOG4105D9P serine threonine protein kinase CX649_09700 ENOG4108ZF3 Phosphatase CX649_09705 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CX649_09710 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CX649_09715 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CX649_09720 ENOG4105C25 Primosomal protein n' CX649_09725 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CX649_09735 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CX649_09740 ENOG4105KC4 UPF0296 protein CX649_09745 ENOG4105DSJ YicC domain protein CX649_09755 ENOG4105F23 Fibronectin-binding protein CX649_09760 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CX649_09765 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CX649_09775 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CX649_09780 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CX649_09785 ENOG4107RIQ Sulfate adenylate transferase CX649_09790 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CX649_09795 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CX649_09800 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CX649_09805 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) CX649_09810 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CX649_09815 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CX649_09830 ENOG4105CXT aspartate transcarbamylase CX649_09845 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CX649_09850 ENOG4105C34 Pseudouridine synthase CX649_09855 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CX649_09865 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CX649_09875 ENOG4105DBK s4 domain protein CX649_09880 ENOG41067XK integral membrane protein CX649_09885 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CX649_09890 ENOG4105DFA alanine racemase domain protein CX649_09895 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CX649_09900 ENOG4105WR5 sporulation protein, YlmC YmxH family CX649_09910 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CX649_09915 ENOG4105FFI sigma-e processing peptidase spoiiga CX649_09920 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CX649_09925 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CX649_09930 ENOG4105K67 small basic protein CX649_09940 ENOG4108R2U division initiation protein CX649_09945 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) CX649_09950 ENOG4105D4A Cell wall formation (By similarity) CX649_09955 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CX649_09960 ENOG4105CNI cell division protein FtsW CX649_09965 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CX649_09970 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CX649_09975 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CX649_09980 ENOG4105CJN penicillin-binding protein CX649_09985 ENOG4105CJN penicillin-binding protein CX649_09995 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CX649_10000 ENOG4108V6E Cell division protein mraZ CX649_10005 ENOG41074B2 UPF0747 protein CX649_10035 ENOG41067VY 50S ribosomal protein L32 CX649_10040 ENOG4105KNH Nucleic acid-binding protein CX649_10045 ENOG4105CDE UPF0348 protein CX649_10050 ENOG41063PX domain protein CX649_10055 ENOG4105D78 K07001 NTE family protein CX649_10060 ENOG4105H20 Sporulation integral membrane protein YlbJ CX649_10065 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CX649_10070 ENOG4106H78 methyltransferase CX649_10085 ENOG4105WUC UPF0298 protein CX649_10110 ENOG4106UY4 Inherit from COG: Scp-like extracellular CX649_10115 ENOG41080XQ Signal transduction protein with cbs domains CX649_10130 ENOG4107X2U Inherit from COG: Exonuclease-like protein CX649_10135 ENOG4108I5C dEAD DEAH box helicase CX649_10170 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) CX649_10175 ENOG4105BZ4 penicillin-binding protein CX649_10185 ENOG4105CSM endonuclease III CX649_10195 ENOG4105C5S asparaginyl-tRNA synthetase CX649_10200 ENOG4105CHM Aminotransferase CX649_10210 ENOG4105YAC CX649_10220 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CX649_10225 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CX649_10230 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CX649_10240 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CX649_10245 ENOG4105CPK Glycosyl transferase (Group 1 CX649_10250 ENOG4108Z5K methylglyoxal synthase CX649_10255 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CX649_10260 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CX649_10265 ENOG4108JYZ YitT family CX649_10290 ENOG4105BZG amino acid carrier protein CX649_10300 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CX649_10305 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) CX649_10315 ENOG4108SXZ UPF0302 protein CX649_10320 ENOG41068YB TPR repeat-containing protein CX649_10330 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CX649_10340 ENOG4105CIH Imidazole acetol-phosphate transaminase CX649_10345 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CX649_10355 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase CX649_10360 ENOG4105DK0 Indole-3-glycerol phosphate synthase CX649_10365 ENOG4108I0Q anthranilate phosphoribosyltransferase CX649_10375 ENOG4105KHN chorismate mutase CX649_10380 ENOG4105D49 3-dehydroquinate synthase CX649_10385 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CX649_10395 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CX649_10400 ENOG4105EAH synthase CX649_10405 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CX649_10410 ENOG4105XXQ heptaprenyl diphosphate synthase component I CX649_10415 ENOG4105WP2 Tryptophan RNA-binding attenuator protein CX649_10420 ENOG4105EUJ GTP cyclohydrolase i CX649_10425 ENOG4105K70 DNA-binding protein CX649_10440 ENOG4106UIA CX649_10455 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CX649_10470 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CX649_10475 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CX649_10480 ENOG41065D1 CX649_10485 ENOG4105S2F CX649_10495 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CX649_10500 ENOG4105F6E Acyl-transferase CX649_10505 ENOG4105CAT Cytidine monophosphate kinase CX649_10515 ENOG4105MSI germination protein ypeb CX649_10525 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) CX649_10530 ENOG4105HDK L-asparaginase CX649_10535 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CX649_10560 ENOG4105I7S Abortive infection protein CX649_10565 ENOG4105C9U ATP-dependent DNA helicase RecQ CX649_10570 ENOG4105T7X CX649_10580 ENOG4108SAX Membrane CX649_10590 ENOG4108JQ1 Dehydrogenase CX649_10605 ENOG4108WBT adenosyltransferase CX649_10610 ENOG4105BZU Histidine kinase CX649_10615 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CX649_10620 ENOG4105CRE cytochrome C CX649_10625 ENOG4107TWT Cytochrome c biogenesis protein CX649_10630 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CX649_10635 ENOG4105FE9 pseudouridine synthase CX649_10645 ENOG4108JIC nucleoside recognition domain protein CX649_10650 ENOG4105DZ1 carboxypeptidase CX649_10655 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CX649_10660 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CX649_10670 ENOG410855V Acylphosphatase CX649_10680 ENOG4108HWW ABC transporter CX649_10685 ENOG4105C2J ABC transporter CX649_10690 ENOG4105DFW ABC transporter CX649_10695 ENOG4108VAC response regulator CX649_10700 ENOG4105C2F Histidine kinase CX649_10710 ENOG4105EWU Squalene--hopene cyclase CX649_10725 ENOG4105CIG ABC transporter CX649_10740 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CX649_10745 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CX649_10750 ENOG4105BZ8 glutamate synthase CX649_10755 ENOG4105CBC glutamate synthase CX649_10760 ENOG4105C5Q Transcriptional regulator CX649_10765 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CX649_10770 ENOG4108QEG Membrane CX649_10775 ENOG4108Y6J UPF0403 protein CX649_10780 ENOG4105C7S Dehydrogenase CX649_10785 ENOG4105CPP Dehydrogenase, E1 component CX649_10800 ENOG4106CCJ Protein of unknown function (DUF2627) CX649_10805 ENOG4107QQR Sporulation CX649_10810 ENOG4105S1Z Stage IV sporulation protein B CX649_10815 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CX649_10820 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CX649_10825 ENOG4105DX0 Hemolysin A CX649_10830 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CX649_10840 ENOG4105CTB Polyprenyl synthetase CX649_10845 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CX649_10850 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CX649_10855 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CX649_10860 ENOG4105M7K Involved in the transcription termination process (By similarity) CX649_10865 ENOG4108ZSR alkaline shock protein CX649_10870 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CX649_10890 ENOG410644B Stage III sporulation protein af CX649_10900 ENOG4105KQ4 Stage iii sporulation protein ad CX649_10905 ENOG4108CQH stage III sporulation protein AC CX649_10910 ENOG4105KR5 Stage iii sporulation protein CX649_10915 ENOG4105CD2 stage iii sporulation protein aa CX649_10920 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CX649_10925 ENOG4105DC7 peptidase M24 CX649_10930 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CX649_10940 ENOG4105CBJ Metal-dependent enzyme CX649_10955 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CX649_10960 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CX649_10965 ENOG4105WZW rhodanese family CX649_10970 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CX649_10975 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CX649_10980 ENOG4105WZW rhodanese family CX649_10985 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CX649_10990 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit CX649_10995 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) CX649_11005 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CX649_11010 ENOG4105KG3 cytidine deaminase CX649_11015 ENOG4107YR5 Diacylglycerol kinase CX649_11020 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CX649_11025 ENOG4105CTJ Metal Dependent Phosphohydrolase CX649_11030 ENOG4105C9A Phoh family CX649_11040 ENOG41068P3 sporulation protein YqfC CX649_11050 ENOG4105DI5 UPF0365 protein CX649_11055 ENOG4105F7J membrane-bound serine protease CX649_11060 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CX649_11075 ENOG4105KTH gatB Yqey CX649_11080 ENOG4105VCC 30S ribosomal protein S21 CX649_11090 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CX649_11095 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CX649_11100 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CX649_11105 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CX649_11110 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CX649_11115 ENOG4105CFG Acts as a chaperone (By similarity) CX649_11120 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CX649_11125 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CX649_11130 ENOG4105CSA Coproporphyrinogen iii oxidase CX649_11135 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CX649_11145 ENOG4108ZRV stage ii sporulation protein p CX649_11155 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) CX649_11160 ENOG4105TQK DNA polymerase iii, delta' subunit CX649_11170 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CX649_11175 ENOG4108UK2 deaminase CX649_11180 ENOG4105KQC Competence protein CX649_11190 ENOG4108D32 Methyltransferase CX649_11200 ENOG4108WF2 Metal Dependent Phosphohydrolase CX649_11205 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CX649_11210 ENOG410812S Rna-binding protein CX649_11220 ENOG4105CQW ribosome biogenesis GTPase YqeH CX649_11225 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CX649_11235 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CX649_11245 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CX649_11255 ENOG4107XRG penicillin-binding protein CX649_11260 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CX649_11265 ENOG4105CFP Peptidase U32 CX649_11270 ENOG4105XYU peptidase (U32 family) CX649_11275 ENOG4108VQJ O-methyltransferase CX649_11280 ENOG4105HHA aminodeoxychorismate lyase CX649_11285 ENOG4105VPH UPF0473 protein CX649_11290 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CX649_11295 ENOG4105VBH UPF0297 protein CX649_11300 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CX649_11305 ENOG4105C02 permease CX649_11310 ENOG41060CR CX649_11315 ENOG4105C7H Helicase, RecD TraA family CX649_11325 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CX649_11330 ENOG4105C3J Cysteine desulfurase CX649_11340 ENOG4105D1H recombination factor protein RarA CX649_11345 ENOG4105CUZ uba thif-type nad fad binding protein CX649_11355 ENOG4105C9M aspartyl-trna synthetase CX649_11360 ENOG4105CUT histidyl-tRNA synthetase CX649_11365 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CX649_11370 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CX649_11375 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CX649_11380 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CX649_11385 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CX649_11390 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CX649_11400 ENOG4105CKP Polysaccharide Biosynthesis Protein CX649_11405 ENOG4105NAP CX649_11410 ENOG4105VIE preprotein translocase, subunit YajC CX649_11415 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CX649_11420 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CX649_11425 ENOG41061AI Protein of unknown function (DUF2905) CX649_11430 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CX649_11435 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CX649_11445 ENOG4105CDY transcriptional regulatory protein CX649_11455 ENOG4107RA1 nh(3)-dependent nad( ) synthetase CX649_11460 ENOG4106678 morphogenetic protein associated with SpoVID CX649_11465 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CX649_11470 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CX649_11475 ENOG4108IYU L-aspartate oxidase CX649_11490 ENOG4105CQC Prephenate dehydratase CX649_11495 ENOG41090I5 UPF0735 ACT domain-containing protein CX649_11500 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CX649_11510 ENOG4105K46 50S ribosomal protein l27 CX649_11515 ENOG4105X36 (ribosomal) protein CX649_11520 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CX649_11525 ENOG4105C03 ribonuclease CX649_11540 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CX649_11545 ENOG4107Y03 Nitroreductase CX649_11555 ENOG4107QMS site-determining protein CX649_11560 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CX649_11565 ENOG4105YHC Rod shape-determining protein MreD CX649_11570 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CX649_11575 ENOG4105DFF Rod shape-determining protein mreb CX649_11580 ENOG4105W5Q DNA repair protein (RadC CX649_11585 ENOG4108Z03 MAF-like protein CX649_11595 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CX649_11615 ENOG41068KH stage VI sporulation protein D CX649_11620 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CX649_11625 ENOG4105D52 delta-aminolevulinic acid dehydratase CX649_11635 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CX649_11645 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CX649_11655 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CX649_11660 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CX649_11665 ENOG4108IUQ atp-dependent protease CX649_11670 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CX649_11675 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CX649_11685 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CX649_11690 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CX649_11695 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CX649_11700 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CX649_11705 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CX649_11710 ENOG4108ZP8 Acetolactate synthase small subunit CX649_11715 ENOG4105C7K acetolactate synthase CX649_11720 ENOG4105UNS Pfam:DUF419 CX649_11735 ENOG4105M59 Phosphodiesterase, mj0936 family CX649_11740 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CX649_11745 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CX649_11750 ENOG4108XJQ germination protein CX649_11755 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CX649_11760 ENOG41067TZ transcriptional regulator, MarR family CX649_11765 ENOG4105PFC Transcriptional regulator CX649_11770 ENOG4105E33 succinate dehydrogenase CX649_11780 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CX649_11790 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CX649_11795 ENOG4105K63 Thioredoxin CX649_11800 ENOG4105C10 Electron transfer flavoprotein CX649_11805 ENOG4105BZJ Electron transfer flavoprotein CX649_11810 ENOG4107Z3H Transcriptional regulator, TetR family CX649_11815 ENOG4105CEY Amp-dependent synthetase and ligase CX649_11825 ENOG4105C98 muts2 protein CX649_11830 ENOG4105DCG PHP domain protein CX649_11840 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) CX649_11845 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CX649_11850 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CX649_11855 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CX649_11865 ENOG4108RWN rrna methyltransferase CX649_11875 ENOG4105CN9 Peptidase m42 family protein CX649_11895 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CX649_11900 ENOG4105VJV 50s ribosomal protein L35 CX649_11905 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CX649_11910 ENOG4106GRI small acid-soluble spore protein H CX649_11915 ENOG4105HNY Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) CX649_11920 ENOG4105C22 threonyL-tRNA synthetase CX649_11925 ENOG4108TDW sporulation protein YtxC CX649_11940 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CX649_11945 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CX649_11950 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CX649_11965 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CX649_11970 ENOG4105C2M dna polymerase I CX649_11975 ENOG4105EPW hflc protein CX649_11980 ENOG4107QJR hflk protein CX649_11985 ENOG4105BZU Histidine kinase CX649_11990 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CX649_12000 ENOG4108HMX isocitrate dehydrogenase (NADP) CX649_12005 ENOG4105BZN citrate synthase CX649_12010 ENOG4105FS0 cytoplasmic membrane protein CX649_12015 ENOG4105CA9 Pyruvate kinase CX649_12020 ENOG4105CTQ phosphohexokinase CX649_12025 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CX649_12030 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CX649_12035 ENOG4105C6K Malic enzyme CX649_12050 ENOG4105M59 Phosphodiesterase, mj0936 family CX649_12055 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CX649_12060 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CX649_12065 ENOG4108XJQ germination protein CX649_12070 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CX649_12075 ENOG41067TZ transcriptional regulator, MarR family CX649_12080 ENOG4105PFC Transcriptional regulator CX649_12085 ENOG4105E33 succinate dehydrogenase CX649_12095 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CX649_12105 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CX649_12110 ENOG4105K63 Thioredoxin CX649_12115 ENOG4105C10 Electron transfer flavoprotein CX649_12120 ENOG4105BZJ Electron transfer flavoprotein CX649_12125 ENOG4107Z3H Transcriptional regulator, TetR family CX649_12130 ENOG4105CEY Amp-dependent synthetase and ligase CX649_12140 ENOG4105C98 muts2 protein CX649_12145 ENOG4105DCG PHP domain protein CX649_12155 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) CX649_12160 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CX649_12165 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CX649_12170 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CX649_12180 ENOG4108RWN rrna methyltransferase CX649_12190 ENOG4105CN9 Peptidase m42 family protein CX649_12210 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CX649_12215 ENOG4105VJV 50s ribosomal protein L35 CX649_12220 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CX649_12225 ENOG4106GRI small acid-soluble spore protein H CX649_12230 ENOG4105HNY Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) CX649_12235 ENOG4105C22 threonyL-tRNA synthetase CX649_12240 ENOG4108TDW sporulation protein YtxC CX649_12255 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CX649_12260 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CX649_12265 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CX649_12280 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CX649_12285 ENOG4105C2M dna polymerase I CX649_12290 ENOG4105EPW hflc protein CX649_12295 ENOG4107QJR hflk protein CX649_12300 ENOG4105BZU Histidine kinase CX649_12305 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CX649_12315 ENOG4108HMX isocitrate dehydrogenase (NADP) CX649_12320 ENOG4105BZN citrate synthase CX649_12325 ENOG4105FS0 cytoplasmic membrane protein CX649_12330 ENOG4105CA9 Pyruvate kinase CX649_12335 ENOG4105CTQ phosphohexokinase CX649_12340 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CX649_12345 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CX649_12350 ENOG4105C6K Malic enzyme