locus-tag	class	description
CX649_00010	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CX649_00015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CX649_00025	COG1984	allophanate hydrolase subunit 2
CX649_00030	COG0508	dehydrogenase complex catalyzes the overall conversion of
CX649_00035	COG0439	Biotin carboxylase
CX649_00040	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CX649_00050	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CX649_00055	COG1012	belongs to the aldehyde dehydrogenase family
CX649_00075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CX649_00080	COG1595	DNA-templated transcription, initiation
CX649_00090	COG1131	(ABC) transporter
CX649_00140	COG0745	RESPONSE REGULATOR receiver
CX649_00145	COG5002	protein histidine kinase activity
CX649_00170	COG3730	PTS system glucitol sorbitol-specific
CX649_00175	COG3732	PTS system glucitol sorbitol-specific
CX649_00185	COG0386	Belongs to the glutathione peroxidase family
CX649_00190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CX649_00195	COG2356	endonuclease I
CX649_00215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CX649_00215	COG2213	PTS system mannitol-specific
CX649_00225	COG3775	system Galactitol-specific IIC component
CX649_00290	COG0477	Major facilitator Superfamily
CX649_00305	COG0583	DNA-binding transcription factor activity
CX649_00320	COG1012	belongs to the aldehyde dehydrogenase family
CX649_00330	COG0196	riboflavin kinase activity
CX649_00335	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CX649_00340	COG0179	Fumarylacetoacetate (FAA) hydrolase
CX649_00355	COG1012	belongs to the aldehyde dehydrogenase family
CX649_00370	COG0559	Belongs to the binding-protein-dependent transport system permease family
CX649_00380	COG0411	ABC transporter
CX649_00385	COG0410	ABC transporter
CX649_00395	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CX649_00440	COG0714	Associated with various cellular activities
CX649_00445	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
CX649_00450	COG1305	Transglutaminase-like
CX649_00455	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CX649_00455	COG0519	Catalyzes the synthesis of GMP from XMP
CX649_00460	COG2252	PERMEase
CX649_00465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CX649_00470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CX649_00475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CX649_00480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CX649_00485	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CX649_00490	COG0047	phosphoribosylformylglycinamidine synthase activity
CX649_00495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CX649_00500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CX649_00505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CX649_00510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CX649_00515	COG0138	bifunctional purine biosynthesis protein purh
CX649_00520	COG0151	Belongs to the GarS family
CX649_00525	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CX649_00530	COG1470	cell adhesion involved in biofilm formation
CX649_00535	COG4496	protein, YerC YecD
CX649_00540	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CX649_00545	COG0210	DNA helicase
CX649_00550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CX649_00555	COG4851	CamS sex pheromone cAM373 precursor
CX649_00565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CX649_00570	COG0154	amidase activity
CX649_00580	COG1597	lipid kinase activity
CX649_00590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CX649_00610	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CX649_00620	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CX649_00640	COG4372	Transposase
CX649_00680	COG2132	Multicopper oxidase
CX649_00705	COG4372	Transposase
CX649_00745	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CX649_00770	COG2188	Transcriptional regulator
CX649_00790	COG1735	metal-dependent hydrolase with the TIM-barrel fold
CX649_00795	COG0626	cystathionine gamma-synthase activity
CX649_00800	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CX649_00805	COG3457	Alanine racemase
CX649_00810	COG0561	phosphatase activity
CX649_00815	COG0363	glucosamine-6-phosphate deaminase activity
CX649_00840	COG2031	fatty acid transporter
CX649_00845	COG0583	DNA-binding transcription factor activity
CX649_00855	COG0477	Major facilitator Superfamily
CX649_00865	COG1309	transcriptional regulator
CX649_00870	COG0579	oxidoreductase
CX649_00875	COG2329	Antibiotic biosynthesis monooxygenase
CX649_00880	COG0686	Belongs to the AlaDH PNT family
CX649_00885	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CX649_00885	COG2508	Transcriptional regulator
CX649_00895	COG1126	abc transporter atp-binding protein
CX649_00905	COG5386	Cell surface protein
CX649_00925	COG4509	Sortase family
CX649_00930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CX649_00955	COG1126	abc transporter atp-binding protein
CX649_00970	COG1309	transcriptional regulator
CX649_01005	COG1518	maintenance of DNA repeat elements
CX649_01010	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CX649_01015	COG0840	transmembrane signaling receptor activity
CX649_01025	COG0582	viral genome integration into host DNA
CX649_01030	COG0490	domain, Protein
CX649_01035	COG0475	glutathione-regulated potassium exporter activity
CX649_01055	COG3842	ATPase activity
CX649_01060	COG1176	ABC-type spermidine putrescine transport system, permease component I
CX649_01065	COG1177	transmembrane transport
CX649_01070	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CX649_01080	COG2814	Major facilitator Superfamily
CX649_01085	COG0753	catalase activity
CX649_01090	COG1132	(ABC) transporter
CX649_01095	COG1132	(ABC) transporter
CX649_01100	COG0561	phosphatase activity
CX649_01105	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CX649_01110	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CX649_01115	COG4605	iron ion homeostasis
CX649_01120	COG4604	ABC transporter, ATP-binding protein
CX649_01125	COG4607	ABC-type enterochelin transport system periplasmic component
CX649_01140	COG1587	Uroporphyrinogen-III synthase
CX649_01155	COG3842	ATPase activity
CX649_01160	COG0395	ABC-type sugar transport system, permease component
CX649_01165	COG1175	transmembrane transport
CX649_01170	COG1653	transport
CX649_01175	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CX649_01180	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CX649_01195	COG1733	regulation of RNA biosynthetic process
CX649_01205	COG1960	acyl-CoA dehydrogenase activity
CX649_01225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CX649_01230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CX649_01235	COG4948	Mandelate Racemase Muconate Lactonizing
CX649_01245	COG2311	Membrane
CX649_01265	COG4840	Belongs to the UPF0435 family
CX649_01270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CX649_01275	COG4980	gas vesicle protein
CX649_01280	COG1295	ribonuclease BN
CX649_01300	COG1511	domain protein
CX649_01305	COG1309	transcriptional regulator
CX649_01315	COG0387	Pfam Sodium calcium exchanger
CX649_01325	COG0535	radical SAM domain protein
CX649_01330	COG1850	ribulose-bisphosphate carboxylase activity
CX649_01335	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
CX649_01340	COG0235	Class ii aldolase
CX649_01345	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CX649_01350	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
CX649_01355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CX649_01360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CX649_01365	COG0436	Aminotransferase
CX649_01380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CX649_01385	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CX649_01425	COG1597	lipid kinase activity
CX649_01445	COG0501	Belongs to the peptidase M48B family
CX649_01450	COG2814	Major facilitator Superfamily
CX649_01470	COG0789	Transcriptional regulator
CX649_01475	COG2801	Transposase and inactivated derivatives
CX649_01490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CX649_01505	COG0626	cystathionine gamma-synthase activity
CX649_01510	COG2329	Antibiotic biosynthesis monooxygenase
CX649_01515	COG0385	Bile acid
CX649_01525	COG2814	Major facilitator Superfamily
CX649_01530	COG2066	Belongs to the glutaminase family
CX649_01540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CX649_01545	COG2271	Major facilitator Superfamily
CX649_01550	COG0028	Belongs to the TPP enzyme family
CX649_01555	COG0583	DNA-binding transcription factor activity
CX649_01560	COG0861	Integral membrane protein TerC family
CX649_01585	COG2137	regulation of response to DNA damage stimulus
CX649_01610	COG0420	3'-5' exonuclease activity
CX649_01615	COG4717	serine-type aminopeptidase activity
CX649_01620	COG3481	metal-dependent phosphohydrolase, HD sub domain
CX649_01630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CX649_01650	COG1846	Transcriptional regulator
CX649_01655	COG4980	gas vesicle protein
CX649_01670	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CX649_01675	COG0537	adenosine 5'-monophosphoramidase activity
CX649_01680	COG4473	ABC transporter
CX649_01685	COG1131	(ABC) transporter
CX649_01690	COG2329	Antibiotic biosynthesis monooxygenase
CX649_01695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CX649_01700	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CX649_01715	COG1609	Transcriptional regulator
CX649_01725	COG1234	tRNA 3'-trailer cleavage
CX649_01735	COG4120	Belongs to the binding-protein-dependent transport system permease family
CX649_01740	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CX649_01740	COG1116	anion transmembrane transporter activity
CX649_01745	COG1396	sequence-specific DNA binding
CX649_01750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CX649_01760	COG0501	Belongs to the peptidase M48B family
CX649_01765	COG1674	ftsk spoiiie
CX649_01770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CX649_01775	COG2309	aminopeptidase activity
CX649_01780	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
CX649_01790	COG1605	Chorismate mutase
CX649_01790	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CX649_01795	COG1609	Transcriptional regulator
CX649_01800	COG0123	including yeast histone deacetylase and acetoin utilization protein
CX649_01805	COG0517	IMP dehydrogenase activity
CX649_01810	COG0454	-acetyltransferase
CX649_01815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CX649_01820	COG0456	acetyltransferase
CX649_01885	COG1077	Cell shape determining protein MreB Mrl
CX649_01890	COG1609	Transcriptional regulator
CX649_01900	COG1984	allophanate hydrolase subunit 2
CX649_01905	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CX649_01910	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CX649_01915	COG1247	-acetyltransferase
CX649_01920	COG0739	heme binding
CX649_01930	COG2385	sporulation resulting in formation of a cellular spore
CX649_01935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CX649_01945	COG4836	Membrane
CX649_01950	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CX649_01955	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CX649_01960	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CX649_01965	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CX649_01970	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CX649_01975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CX649_01980	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CX649_01985	COG0356	it plays a direct role in the translocation of protons across the membrane
CX649_02000	COG1404	Belongs to the peptidase S8 family
CX649_02005	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CX649_02010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CX649_02020	COG0698	ribose 5-phosphate isomerase
CX649_02025	COG0840	transmembrane signaling receptor activity
CX649_02030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CX649_02035	COG1971	Probably functions as a manganese efflux pump
CX649_02040	COG0009	L-threonylcarbamoyladenylate synthase
CX649_02055	COG2890	protein-(glutamine-N5) methyltransferase activity
CX649_02060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CX649_02065	COG0789	Transcriptional regulator
CX649_02075	COG1435	thymidine kinase activity
CX649_02080	COG0254	rRNA binding
CX649_02085	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CX649_02090	COG1494	fructose-1,6-bisphosphatase
CX649_02095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CX649_02100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CX649_02105	COG0191	fructose-bisphosphate aldolase activity
CX649_02110	COG2204	response regulator
CX649_02115	COG4821	SIS domain
CX649_02125	COG0504	CTP synthase activity
CX649_02130	COG3343	RNA polymerase activity
CX649_02135	COG0247	lactate metabolic process
CX649_02135	COG2181	nitrate reductase activity
CX649_02140	COG1595	DNA-templated transcription, initiation
CX649_02145	COG0018	arginyl-trna synthetase
CX649_02150	COG4506	Protein conserved in bacteria
CX649_02155	COG0010	Belongs to the arginase family
CX649_02160	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CX649_02165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CX649_02185	COG4844	belongs to the
CX649_02190	COG1078	dGTPase activity
CX649_02195	COG3465	dGTPase activity
CX649_02200	COG1994	Peptidase M50
CX649_02210	COG0280	phosphate acetyltransferase
CX649_02225	COG2267	carboxylic ester hydrolase activity
CX649_02230	COG3773	Cell wall hydrolase
CX649_02245	COG3973	AAA domain
CX649_02255	COG0039	L-malate dehydrogenase activity
CX649_02260	COG1620	l-lactate permease
CX649_02320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CX649_02325	COG0732	type I restriction modification DNA specificity domain
CX649_02330	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CX649_02355	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CX649_02365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CX649_02370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CX649_02375	COG4853	Protein conserved in bacteria
CX649_02385	COG5002	protein histidine kinase activity
CX649_02390	COG0745	RESPONSE REGULATOR receiver
CX649_02405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CX649_02410	COG0305	Participates in initiation and elongation during chromosome replication
CX649_02415	COG0359	binds to the 23S rRNA
CX649_02420	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CX649_02425	COG4241	membrane
CX649_02430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CX649_02435	COG0629	single-stranded DNA binding
CX649_02440	COG0360	Binds together with S18 to 16S ribosomal RNA
CX649_02445	COG0012	GTP binding
CX649_02450	COG4481	Protein conserved in bacteria
CX649_02460	COG1475	DNA binding
CX649_02465	COG1192	Involved in chromosome partitioning
CX649_02470	COG1475	DNA binding
CX649_02475	COG0357	Ribosomal RNA small subunit methyltransferase G
CX649_02480	COG0445	tRNA wobble uridine modification
CX649_02485	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CX649_02490	COG1847	R3H domain protein
CX649_02495	COG0706	membrane insertase activity
CX649_02500	COG0594	ribonuclease P activity
CX649_02505	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CX649_02510	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CX649_02520	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CX649_02540	COG1285	pathogenesis
CX649_02545	COG4463	regulation of RNA biosynthetic process
CX649_02550	COG3880	PFAM UvrB UvrC protein
CX649_02555	COG3869	Catalyzes the specific phosphorylation of arginine residues in
CX649_02560	COG0542	response to heat
CX649_02565	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CX649_02570	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CX649_02575	COG4956	integral membrane protein (PIN domain superfamily)
CX649_02580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CX649_02585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CX649_02590	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CX649_02595	COG1045	serine acetyltransferase
CX649_02600	COG0215	cysteine-tRNA ligase activity
CX649_02605	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CX649_02610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CX649_02615	COG3688	RNA-binding protein containing a PIN domain
CX649_02625	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CX649_02630	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CX649_02635	COG0250	Participates in transcription elongation, termination and antitermination
CX649_02645	COG0081	regulation of translation
CX649_02650	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CX649_02655	COG0222	ribosome binding
CX649_02660	COG2813	Specifically methylates the guanine in position
CX649_02665	COG0085	RNA polymerase activity
CX649_02670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CX649_02675	COG1358	cellular component organization or biogenesis
CX649_02680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CX649_02685	COG0049	tRNA binding
CX649_02690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CX649_02695	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CX649_02700	COG0051	transcription antitermination factor activity, RNA binding
CX649_02705	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CX649_02710	COG0088	Forms part of the polypeptide exit tunnel
CX649_02715	COG0089	rRNA binding
CX649_02720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CX649_02725	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CX649_02730	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CX649_02735	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CX649_02740	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CX649_02745	COG0255	Belongs to the universal ribosomal protein uL29 family
CX649_02750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CX649_02755	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CX649_02760	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CX649_02765	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CX649_02770	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CX649_02775	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CX649_02780	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CX649_02785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CX649_02790	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CX649_02800	COG0200	Binds to the 23S rRNA
CX649_02805	COG0201	protein transport
CX649_02810	COG0563	adenylate kinase activity
CX649_02815	COG0024	Methionine aminopeptidase
CX649_02820	COG2163	COG2163 Ribosomal protein L14E L6E L27E
CX649_02825	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CX649_02830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CX649_02835	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CX649_02840	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CX649_02850	COG0203	ribosomal protein L17
CX649_02855	COG1122	ATPase activity
CX649_02860	COG1122	ATPase activity
CX649_02865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CX649_02870	COG0101	tRNA pseudouridine synthase activity
CX649_02875	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CX649_02880	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CX649_02900	COG0860	N-Acetylmuramoyl-L-alanine amidase
CX649_02905	COG0489	protein tyrosine kinase activity
CX649_02915	COG2194	sulfuric ester hydrolase activity
CX649_02920	COG0726	polysaccharide deacetylase
CX649_02935	COG2011	ABC-type metal ion transport system permease component
CX649_02950	COG0667	Aldo Keto reductase
CX649_02955	COG1960	acyl-CoA dehydrogenase activity
CX649_02960	COG1960	acyl-CoA dehydrogenase activity
CX649_02965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CX649_02970	COG3885	ferrous iron binding
CX649_02970	COG2078	PFAM AMMECR1 domain protein
CX649_02985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CX649_03015	COG0483	inositol monophosphate 1-phosphatase activity
CX649_03020	COG2186	Transcriptional regulator
CX649_03025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CX649_03030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CX649_03040	COG0784	Response regulator, receiver
CX649_03045	COG4191	Histidine kinase
CX649_03050	COG0765	amino acid transport
CX649_03055	COG0765	amino acid transport
CX649_03090	COG0693	protein deglycase activity
CX649_03100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CX649_03105	COG0702	epimerase
CX649_03110	COG2807	transmembrane transport
CX649_03115	COG1136	(ABC) transporter
CX649_03120	COG0577	efflux transmembrane transporter activity
CX649_03125	COG0745	RESPONSE REGULATOR receiver
CX649_03130	COG3850	Histidine kinase
CX649_03130	COG5002	protein histidine kinase activity
CX649_03135	COG2514	catechol 2,3-dioxygenase activity
CX649_03150	COG0069	glutamate synthase activity
CX649_03155	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
CX649_03160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CX649_03170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CX649_03175	COG1181	Belongs to the D-alanine--D-alanine ligase family
CX649_03180	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CX649_03190	COG0513	Belongs to the DEAD box helicase family
CX649_03195	COG3402	PFAM membrane-flanked domain
CX649_03200	COG3428	Bacterial PH domain
CX649_03205	COG0705	Rhomboid family
CX649_03210	COG0736	holo-[acyl-carrier-protein] synthase activity
CX649_03215	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CX649_03225	COG0864	Transcriptional regulator
CX649_03230	COG2337	Toxic component of a toxin-antitoxin (TA) module
CX649_03235	COG1366	Belongs to the anti-sigma-factor antagonist family
CX649_03240	COG1366	Belongs to the anti-sigma-factor antagonist family
CX649_03245	COG2172	sigma factor antagonist activity
CX649_03250	COG2208	phosphoserine phosphatase activity
CX649_03255	COG1366	Belongs to the anti-sigma-factor antagonist family
CX649_03265	COG1191	sigma factor activity
CX649_03270	COG2208	phosphoserine phosphatase activity
CX649_03275	COG2183	response to ionizing radiation
CX649_03285	COG3091	SprT-like family
CX649_03350	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CX649_03355	COG0187	DNA topoisomerase II activity
CX649_03360	COG1832	CoA-binding protein
CX649_03365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CX649_03370	COG1199	ATP-dependent helicase activity
CX649_03370	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CX649_03380	COG0004	ammonium transporteR
CX649_03390	COG4841	protein insertion into membrane
CX649_03400	COG0824	Thioesterase
CX649_03420	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CX649_03425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CX649_03450	COG4846	Membrane protein involved in cytochrome C biogenesis
CX649_03455	COG2201	protein-glutamate methylesterase activity
CX649_03460	COG0785	Cytochrome C biogenesis protein
CX649_03465	COG3763	UPF0154 protein
CX649_03480	COG4224	UPF0291 protein
CX649_03485	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CX649_03495	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CX649_03500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CX649_03505	COG0204	Acyl-transferase
CX649_03510	COG1611	Belongs to the LOG family
CX649_03515	COG0667	Aldo Keto reductase
CX649_03520	COG0400	carboxylic ester hydrolase activity
CX649_03525	COG0346	lactoylglutathione lyase activity
CX649_03530	COG1609	Transcriptional regulator
CX649_03555	COG4585	Histidine kinase
CX649_03560	COG2197	response regulator
CX649_03570	COG0840	transmembrane signaling receptor activity
CX649_03575	COG2200	EAL domain
CX649_03605	COG3180	Ammonia monooxygenase
CX649_03610	COG0583	DNA-binding transcription factor activity
CX649_03625	COG1012	belongs to the aldehyde dehydrogenase family
CX649_03630	COG0745	RESPONSE REGULATOR receiver
CX649_03635	COG5002	protein histidine kinase activity
CX649_03635	COG3850	Histidine kinase
CX649_03660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CX649_03665	COG1024	Enoyl-CoA hydratase
CX649_03685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CX649_03690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CX649_03720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CX649_03725	COG0187	DNA topoisomerase II activity
CX649_03730	COG1832	CoA-binding protein
CX649_03735	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CX649_03740	COG1199	ATP-dependent helicase activity
CX649_03740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CX649_03750	COG0004	ammonium transporteR
CX649_03760	COG4841	protein insertion into membrane
CX649_03770	COG0824	Thioesterase
CX649_03790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CX649_03795	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CX649_03820	COG4846	Membrane protein involved in cytochrome C biogenesis
CX649_03825	COG2201	protein-glutamate methylesterase activity
CX649_03830	COG0785	Cytochrome C biogenesis protein
CX649_03835	COG3763	UPF0154 protein
CX649_03850	COG4224	UPF0291 protein
CX649_03855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CX649_03865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CX649_03870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CX649_03875	COG0204	Acyl-transferase
CX649_03880	COG1611	Belongs to the LOG family
CX649_03885	COG0667	Aldo Keto reductase
CX649_03890	COG0400	carboxylic ester hydrolase activity
CX649_03895	COG0346	lactoylglutathione lyase activity
CX649_03900	COG1609	Transcriptional regulator
CX649_03925	COG4585	Histidine kinase
CX649_03930	COG2197	response regulator
CX649_03940	COG0840	transmembrane signaling receptor activity
CX649_03945	COG2200	EAL domain
CX649_03975	COG3180	Ammonia monooxygenase
CX649_03980	COG0583	DNA-binding transcription factor activity
CX649_03995	COG1012	belongs to the aldehyde dehydrogenase family
CX649_04000	COG0745	RESPONSE REGULATOR receiver
CX649_04005	COG5002	protein histidine kinase activity
CX649_04005	COG3850	Histidine kinase
CX649_04030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CX649_04035	COG1024	Enoyl-CoA hydratase
CX649_04055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CX649_04060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CX649_04120	COG0501	Belongs to the peptidase M48B family
CX649_04160	COG1349	DNA-binding transcription factor activity
CX649_04165	COG1012	belongs to the aldehyde dehydrogenase family
CX649_04170	COG3718	enzyme involved in inositol metabolism
CX649_04175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CX649_04180	COG3962	Belongs to the TPP enzyme family
CX649_04185	COG1082	Xylose isomerase domain protein TIM barrel
CX649_04195	COG0673	inositol 2-dehydrogenase activity
CX649_04200	COG1129	ABC transporter
CX649_04205	COG1172	Belongs to the binding-protein-dependent transport system permease family
CX649_04210	COG1879	ABC-type sugar transport system periplasmic component
CX649_04215	COG0673	inositol 2-dehydrogenase activity
CX649_04220	COG0191	fructose-bisphosphate aldolase activity
CX649_04235	COG0247	lactate metabolic process
CX649_04240	COG0277	FAD linked oxidase domain protein
CX649_04245	COG2186	Transcriptional regulator
CX649_04270	COG0409	Hydrogenase expression formation protein
CX649_04275	COG0298	carbon dioxide binding
CX649_04320	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CX649_04325	COG0375	protein maturation
CX649_04360	COG3627	carbon phosphorus lyase activity
CX649_04365	COG4107	phosphonate C-P lyase system protein PhnK
CX649_04370	COG3454	Phosphonate metabolism
CX649_04380	COG4778	phosphonate C-P lyase system protein PhnL
CX649_04390	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CX649_04395	COG3639	organic phosphonate transmembrane transporter activity
CX649_04400	COG3639	organic phosphonate transmembrane transporter activity
CX649_04405	COG0613	PHP domain protein
CX649_04415	COG1131	(ABC) transporter
CX649_04440	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CX649_04450	COG4149	molybdate abc transporter
CX649_04455	COG3842	ATPase activity
CX649_04465	COG0508	dehydrogenase complex catalyzes the overall conversion of
CX649_04470	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CX649_04475	COG0303	'Molybdopterin
CX649_04485	COG0803	Belongs to the bacterial solute-binding protein 9 family
CX649_04490	COG1121	(ABC) transporter
CX649_04495	COG1321	iron dependent repressor
CX649_04495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CX649_04500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CX649_04505	COG1321	iron dependent repressor
CX649_04515	COG3764	Sortase (surface protein transpeptidase)
CX649_04520	COG1113	amino acid transport
CX649_04525	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CX649_04525	COG4499	WXG100 protein secretion system (Wss), protein YukC
CX649_04540	COG0681	Belongs to the peptidase S26 family
CX649_04585	COG3730	PTS system glucitol sorbitol-specific
CX649_04590	COG3732	PTS system glucitol sorbitol-specific
CX649_04600	COG2390	Transcriptional regulator
CX649_04605	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CX649_04610	COG0508	dehydrogenase complex catalyzes the overall conversion of
CX649_04610	COG0022	dehydrogenase e1 component
CX649_04615	COG0508	dehydrogenase complex catalyzes the overall conversion of
CX649_04620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CX649_04625	COG2390	Transcriptional regulator
CX649_04630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CX649_04635	COG3414	Phosphotransferase system galactitol-specific IIB component
CX649_04640	COG3775	system Galactitol-specific IIC component
CX649_04650	COG3290	protein histidine kinase activity
CX649_04655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CX649_04660	COG1301	dicarboxylic acid transport
CX649_04665	COG1482	cell wall glycoprotein biosynthetic process
CX649_04680	COG1316	TRANSCRIPTIONal
CX649_04690	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CX649_04700	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CX649_04710	COG0463	Glycosyl transferase, family 2
CX649_04720	COG2076	Multidrug Resistance protein
CX649_04730	COG4193	domain, Protein
CX649_04735	COG0728	peptidoglycan biosynthetic process
CX649_04745	COG0438	transferase activity, transferring glycosyl groups
CX649_04750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CX649_04755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CX649_04760	COG1316	TRANSCRIPTIONal
CX649_04765	COG1739	Uncharacterized protein family UPF0029
CX649_04770	COG4585	Histidine kinase
CX649_04775	COG2197	response regulator
CX649_04795	COG1216	Glycosyl transferase, family 2
CX649_04810	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CX649_04815	COG4310	Domain of unknown function (DUF2172)
CX649_04820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CX649_04820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CX649_04830	COG2089	acid synthase
CX649_04835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CX649_04870	COG0604	alcohol dehydrogenase
CX649_04885	COG1309	transcriptional regulator
CX649_04890	COG3584	3D domain protein
CX649_04890	COG1388	LysM domain
CX649_04900	COG0670	Belongs to the BI1 family
CX649_04915	COG1012	belongs to the aldehyde dehydrogenase family
CX649_04925	COG2814	Major facilitator Superfamily
CX649_04940	COG3711	transcriptional antiterminator
CX649_04945	COG2723	6-phospho-beta-galactosidase activity
CX649_04950	COG2723	6-phospho-beta-galactosidase activity
CX649_04955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CX649_04955	COG2190	(PTS) system
CX649_04955	COG1263	PTS System
CX649_04960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CX649_04965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CX649_04970	COG1116	anion transmembrane transporter activity
CX649_04975	COG5278	phosphoserine phosphatase activity
CX649_04975	COG0840	transmembrane signaling receptor activity
CX649_04985	COG3665	Urea carboxylase-associated protein
CX649_04990	COG0439	Biotin carboxylase
CX649_05020	COG4152	abc transporter atp-binding protein
CX649_05025	COG1668	transmembrane transport
CX649_05030	COG0840	transmembrane signaling receptor activity
CX649_05035	COG1028	Short-chain dehydrogenase reductase Sdr
CX649_05035	COG3347	Dehydrogenase
CX649_05040	COG1349	DNA-binding transcription factor activity
CX649_05045	COG4154	Belongs to the RbsD FucU family
CX649_05050	COG1070	Carbohydrate kinase
CX649_05055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CX649_05060	COG1129	ABC transporter
CX649_05065	COG1172	Belongs to the binding-protein-dependent transport system permease family
CX649_05070	COG1879	ABC-type sugar transport system periplasmic component
CX649_05075	COG0235	Class ii aldolase
CX649_05080	COG1070	Carbohydrate kinase
CX649_05090	COG1069	ribulokinase activity
CX649_05095	COG0183	Belongs to the thiolase family
CX649_05100	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CX649_05105	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CX649_05110	COG0583	DNA-binding transcription factor activity
CX649_05115	COG0145	ligase activity
CX649_05120	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
CX649_05125	COG4647	ligase activity
CX649_05155	COG3842	ATPase activity
CX649_05160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CX649_05175	COG1442	glycosyl transferase family 8
CX649_05180	COG2508	Transcriptional regulator
CX649_05185	COG1250	3-hydroxyacyl-CoA dehydrogenase
CX649_05190	COG1024	Enoyl-CoA hydratase
CX649_05195	COG0318	PFAM AMP-dependent synthetase and ligase
CX649_05205	COG1960	acyl-CoA dehydrogenase activity
CX649_05215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CX649_05230	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CX649_05245	COG0179	Fumarylacetoacetate (FAA) hydrolase
CX649_05265	COG1334	flagellar protein FlaG
CX649_05270	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CX649_05275	COG1516	flagellar protein fliS
CX649_05285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CX649_05290	COG0653	protein targeting
CX649_05300	COG2010	Cytochrome c
CX649_05305	COG2884	Cell division ATP-binding protein ftsE
CX649_05310	COG2177	Part of the ABC transporter FtsEX involved in
CX649_05315	COG0739	heme binding
CX649_05320	COG3409	Peptidoglycan-binding domain 1 protein
CX649_05320	COG0793	Belongs to the peptidase S41A family
CX649_05325	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CX649_05340	COG0179	Fumarylacetoacetate (FAA) hydrolase
CX649_05360	COG1334	flagellar protein FlaG
CX649_05365	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CX649_05370	COG1516	flagellar protein fliS
CX649_05380	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CX649_05385	COG0653	protein targeting
CX649_05395	COG2010	Cytochrome c
CX649_05400	COG2884	Cell division ATP-binding protein ftsE
CX649_05405	COG2177	Part of the ABC transporter FtsEX involved in
CX649_05410	COG0739	heme binding
CX649_05415	COG0793	Belongs to the peptidase S41A family
CX649_05415	COG3409	Peptidoglycan-binding domain 1 protein
CX649_05420	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CX649_05435	COG0179	Fumarylacetoacetate (FAA) hydrolase
CX649_05455	COG1334	flagellar protein FlaG
CX649_05460	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CX649_05465	COG1516	flagellar protein fliS
CX649_05475	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CX649_05480	COG0653	protein targeting
CX649_05490	COG2010	Cytochrome c
CX649_05495	COG2884	Cell division ATP-binding protein ftsE
CX649_05500	COG2177	Part of the ABC transporter FtsEX involved in
CX649_05505	COG0739	heme binding
CX649_05510	COG3409	Peptidoglycan-binding domain 1 protein
CX649_05510	COG0793	Belongs to the peptidase S41A family
CX649_05515	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CX649_05530	COG0179	Fumarylacetoacetate (FAA) hydrolase
CX649_05550	COG1334	flagellar protein FlaG
CX649_05555	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CX649_05560	COG1516	flagellar protein fliS
CX649_05570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CX649_05575	COG0653	protein targeting
CX649_05585	COG2010	Cytochrome c
CX649_05590	COG2884	Cell division ATP-binding protein ftsE
CX649_05595	COG2177	Part of the ABC transporter FtsEX involved in
CX649_05600	COG0739	heme binding
CX649_05605	COG3409	Peptidoglycan-binding domain 1 protein
CX649_05605	COG0793	Belongs to the peptidase S41A family
CX649_05610	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CX649_05625	COG0179	Fumarylacetoacetate (FAA) hydrolase
CX649_05645	COG1334	flagellar protein FlaG
CX649_05650	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CX649_05655	COG1516	flagellar protein fliS
CX649_05665	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CX649_05670	COG0653	protein targeting
CX649_05680	COG2010	Cytochrome c
CX649_05685	COG2884	Cell division ATP-binding protein ftsE
CX649_05690	COG2177	Part of the ABC transporter FtsEX involved in
CX649_05695	COG0739	heme binding
CX649_05700	COG3409	Peptidoglycan-binding domain 1 protein
CX649_05700	COG0793	Belongs to the peptidase S41A family
CX649_05705	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CX649_05720	COG0179	Fumarylacetoacetate (FAA) hydrolase
CX649_05740	COG1334	flagellar protein FlaG
CX649_05745	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CX649_05750	COG1516	flagellar protein fliS
CX649_05760	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CX649_05765	COG0653	protein targeting
CX649_05775	COG2010	Cytochrome c
CX649_05780	COG2884	Cell division ATP-binding protein ftsE
CX649_05785	COG2177	Part of the ABC transporter FtsEX involved in
CX649_05790	COG0739	heme binding
CX649_05795	COG3409	Peptidoglycan-binding domain 1 protein
CX649_05795	COG0793	Belongs to the peptidase S41A family
CX649_05800	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CX649_05815	COG0179	Fumarylacetoacetate (FAA) hydrolase
CX649_05835	COG1334	flagellar protein FlaG
CX649_05840	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CX649_05845	COG1516	flagellar protein fliS
CX649_05855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CX649_05860	COG0653	protein targeting
CX649_05870	COG2010	Cytochrome c
CX649_05875	COG2884	Cell division ATP-binding protein ftsE
CX649_05880	COG2177	Part of the ABC transporter FtsEX involved in
CX649_05885	COG0739	heme binding
CX649_05890	COG0793	Belongs to the peptidase S41A family
CX649_05890	COG3409	Peptidoglycan-binding domain 1 protein
CX649_05895	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
CX649_05910	COG0179	Fumarylacetoacetate (FAA) hydrolase
CX649_05930	COG1334	flagellar protein FlaG
CX649_05935	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CX649_05940	COG1516	flagellar protein fliS
CX649_05950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CX649_05955	COG0653	protein targeting
CX649_05965	COG2010	Cytochrome c
CX649_05970	COG2884	Cell division ATP-binding protein ftsE
CX649_05975	COG2177	Part of the ABC transporter FtsEX involved in
CX649_05980	COG0739	heme binding
CX649_05985	COG0793	Belongs to the peptidase S41A family
CX649_05985	COG3409	Peptidoglycan-binding domain 1 protein
CX649_06000	COG1950	PFAM Membrane protein of
CX649_06005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CX649_06010	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CX649_06015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CX649_06020	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CX649_06025	COG0546	phosphoglycolate phosphatase activity
CX649_06030	COG0110	maltose O-acetyltransferase activity
CX649_06035	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CX649_06040	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CX649_06045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CX649_06050	COG0131	Imidazoleglycerol-phosphate dehydratase
CX649_06055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CX649_06060	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CX649_06065	COG0107	imidazoleglycerol-phosphate synthase activity
CX649_06070	COG0140	phosphoribosyl-ATP diphosphatase activity
CX649_06070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CX649_06075	COG0457	Tetratricopeptide repeat
CX649_06080	COG0492	ferredoxin-NADP+ reductase activity
CX649_06085	COG1051	belongs to the nudix hydrolase family
CX649_06090	COG1660	Displays ATPase and GTPase activities
CX649_06095	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CX649_06100	COG1481	regulation of sporulation
CX649_06105	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CX649_06110	COG0740	serine-type endopeptidase activity
CX649_06130	COG3279	Response regulator of the LytR AlgR family
CX649_06135	COG0427	acetyl-CoA hydrolase
CX649_06140	COG1929	Belongs to the glycerate kinase type-1 family
CX649_06150	COG1486	melibiose metabolic process
CX649_06170	COG1518	maintenance of DNA repeat elements
CX649_06175	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CX649_06215	COG0788	formyltetrahydrofolate deformylase activity
CX649_06220	COG0789	Transcriptional regulator
CX649_06225	COG0114	fumarate hydratase activity
CX649_06235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CX649_06240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CX649_06245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CX649_06250	COG1120	ATPase activity
CX649_06265	COG5577	PFAM Coat F domain
CX649_06275	COG1250	3-hydroxyacyl-CoA dehydrogenase
CX649_06275	COG1024	Enoyl-CoA hydratase
CX649_06280	COG0183	Belongs to the thiolase family
CX649_06285	COG1960	acyl-CoA dehydrogenase activity
CX649_06290	COG1393	Belongs to the ArsC family
CX649_06295	COG0509	glycine decarboxylation via glycine cleavage system
CX649_06300	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
CX649_06305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CX649_06315	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CX649_06320	COG2011	ABC-type metal ion transport system permease component
CX649_06325	COG1464	Belongs to the NlpA lipoprotein family
CX649_06340	COG0396	ATPase activity
CX649_06345	COG0719	Fe-S assembly protein
CX649_06350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CX649_06355	COG0822	iron-sulfur transferase activity
CX649_06360	COG0719	Fe-S assembly protein
CX649_06370	COG4282	regulation of fungal-type cell wall biogenesis
CX649_06375	COG1801	Protein of unknown function DUF72
CX649_06380	COG0737	Belongs to the 5'-nucleotidase family
CX649_06385	COG3377	Domain of unknown function (DUF1805)
CX649_06390	COG0739	heme binding
CX649_06395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CX649_06405	COG4470	Protein conserved in bacteria
CX649_06420	COG2445	Protein of unknown function DUF86
CX649_06425	COG0647	UMP catabolic process
CX649_06430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CX649_06435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CX649_06440	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CX649_06445	COG0460	homoserine dehydrogenase
CX649_06450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CX649_06455	COG0083	homoserine kinase activity
CX649_06460	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CX649_06465	COG4837	Protein of unknown function (DUF1462)
CX649_06475	COG1252	NADH dehydrogenase
CX649_06485	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CX649_06490	COG0316	Belongs to the HesB IscA family
CX649_06495	COG0492	ferredoxin-NADP+ reductase activity
CX649_06500	COG1252	NADH dehydrogenase
CX649_06525	COG1363	Peptidase, m42
CX649_06530	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
CX649_06535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CX649_06540	COG4848	Belongs to the UPF0354 family
CX649_06550	COG1288	antiporter activity
CX649_06555	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CX649_06560	COG2224	Isocitrate lyase
CX649_06570	COG4903	ComK protein
CX649_06580	COG0398	Pfam SNARE associated Golgi protein
CX649_06585	COG0681	Belongs to the peptidase S26 family
CX649_06590	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CX649_06595	COG1074	ATP-dependent DNA helicase activity
CX649_06600	COG0420	3'-5' exonuclease activity
CX649_06605	COG0419	ATPase involved in DNA repair
CX649_06640	COG1959	2 iron, 2 sulfur cluster binding
CX649_06645	COG5583	Uncharacterized small protein (DUF2292)
CX649_06650	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CX649_06655	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CX649_06660	COG4208	sulfate ABC transporter
CX649_06670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CX649_06675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CX649_06680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CX649_06685	COG1116	anion transmembrane transporter activity
CX649_06700	COG0084	hydrolase, TatD family'
CX649_06705	COG0179	Fumarylacetoacetate (FAA) hydrolase
CX649_06720	COG0367	asparagine synthase
CX649_06735	COG2706	6-phosphogluconolactonase activity
CX649_06740	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CX649_06745	COG1131	(ABC) transporter
CX649_06760	COG1028	Short-chain dehydrogenase reductase Sdr
CX649_06770	COG1132	(ABC) transporter
CX649_06780	COG4555	ABC transporter
CX649_06790	COG0646	methionine synthase
CX649_06790	COG1410	methionine synthase
CX649_06795	COG0646	methionine synthase
CX649_06795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CX649_06800	COG1666	GTP binding
CX649_06815	COG1307	EDD domain protein, DegV family
CX649_06825	COG0561	phosphatase activity
CX649_06830	COG1073	alpha beta
CX649_06835	COG2151	metal-sulfur cluster biosynthetic enzyme
CX649_06840	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CX649_06845	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CX649_06860	COG0505	Belongs to the CarA family
CX649_06865	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CX649_06870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CX649_06880	COG0542	response to heat
CX649_06890	COG2267	carboxylic ester hydrolase activity
CX649_06900	COG1744	ABC transporter substrate-binding protein PnrA-like
CX649_06910	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CX649_06915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CX649_06945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CX649_06970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CX649_07015	COG1091	dTDP-4-dehydrorhamnose reductase activity
CX649_07025	COG4641	Protein conserved in bacteria
CX649_07070	COG2323	membrane
CX649_07075	COG2153	protein acetylation
CX649_07080	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CX649_07085	COG2382	esterase
CX649_07100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CX649_07105	COG0626	cystathionine gamma-synthase activity
CX649_07110	COG0626	cystathionine gamma-synthase activity
CX649_07170	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CX649_07180	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CX649_07210	COG1024	Enoyl-CoA hydratase
CX649_07215	COG0477	Major facilitator Superfamily
CX649_07245	COG2190	(PTS) system
CX649_07250	COG1263	PTS System
CX649_07250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CX649_07255	COG0366	Alpha amylase catalytic
CX649_07260	COG2188	Transcriptional regulator
CX649_07270	COG1609	Transcriptional regulator
CX649_07275	COG1263	PTS System
CX649_07275	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CX649_07280	COG1621	beta-fructofuranosidase activity
CX649_07285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CX649_07300	COG2814	Major facilitator Superfamily
CX649_07310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CX649_07320	COG0167	dihydroorotate dehydrogenase activity
CX649_07330	COG2843	Capsule synthesis protein
CX649_07335	COG1294	oxidase, subunit
CX649_07340	COG1271	oxidase subunit
CX649_07355	COG1131	(ABC) transporter
CX649_07370	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CX649_07375	COG3383	formate dehydrogenase (NAD+) activity
CX649_07380	COG2427	Protein of unknown function (DUF1641)
CX649_07385	COG0326	Molecular chaperone. Has ATPase activity
CX649_07395	COG1408	metallophosphoesterase
CX649_07405	COG2814	Major facilitator Superfamily
CX649_07410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CX649_07420	COG1414	Transcriptional regulator
CX649_07425	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CX649_07435	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CX649_07455	COG0824	Thioesterase
CX649_07460	COG1021	2,3-dihydroxybenzoate-AMP ligase
CX649_07470	COG1136	(ABC) transporter
CX649_07470	COG0577	efflux transmembrane transporter activity
CX649_07480	COG1476	TRANSCRIPTIONal
CX649_07490	COG1414	Transcriptional regulator
CX649_07495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CX649_07505	COG0069	glutamate synthase activity
CX649_07520	COG0004	ammonium transporteR
CX649_07525	COG1960	acyl-CoA dehydrogenase activity
CX649_07540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CX649_07565	COG2322	membrane
CX649_07570	COG0589	response to stress
CX649_07580	COG0726	polysaccharide deacetylase
CX649_07585	COG0492	ferredoxin-NADP+ reductase activity
CX649_07610	COG1533	DNA photolyase activity
CX649_07625	COG3773	Cell wall hydrolase
CX649_07640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CX649_07645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CX649_07650	COG1120	ATPase activity
CX649_07655	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CX649_07660	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CX649_07665	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CX649_07670	COG1492	cobalamin metabolic process
CX649_07675	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CX649_07700	COG0789	Transcriptional regulator
CX649_07705	COG1253	flavin adenine dinucleotide binding
CX649_07710	COG3002	Belongs to the UPF0753 family
CX649_07715	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CX649_07720	COG5609	conserved protein (DUF2294)
CX649_07725	COG0527	aspartate kinase activity
CX649_07730	COG0840	transmembrane signaling receptor activity
CX649_07740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CX649_07745	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CX649_07750	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CX649_07760	COG1122	ATPase activity
CX649_07775	COG0559	Belongs to the binding-protein-dependent transport system permease family
CX649_07795	COG0831	urea catabolic process
CX649_07800	COG0832	Belongs to the urease beta subunit family
CX649_07810	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CX649_07845	COG1119	ATPase activity
CX649_07850	COG0402	S-adenosylhomocysteine deaminase activity
CX649_07880	COG0402	S-adenosylhomocysteine deaminase activity
CX649_07885	COG0655	NAD(P)H dehydrogenase (quinone) activity
CX649_07890	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CX649_07900	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CX649_07905	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CX649_07910	COG2080	2 iron, 2 sulfur cluster binding
CX649_07930	COG2309	aminopeptidase activity
CX649_07935	COG1960	acyl-CoA dehydrogenase activity
CX649_07940	COG2223	nitrite transmembrane transporter activity
CX649_07955	COG0583	DNA-binding transcription factor activity
CX649_07960	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CX649_07965	COG4637	Psort location Cytoplasmic, score
CX649_07970	COG0569	domain protein
CX649_07975	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CX649_07985	COG0561	phosphatase activity
CX649_07990	COG0242	peptide deformylase activity
CX649_08005	COG0022	dehydrogenase e1 component
CX649_08010	COG0508	dehydrogenase complex catalyzes the overall conversion of
CX649_08020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CX649_08040	COG1982	Orn Lys Arg decarboxylase major
CX649_08050	COG4493	Belongs to the UPF0637 family
CX649_08055	COG0483	inositol monophosphate 1-phosphatase activity
CX649_08075	COG4896	Protein conserved in bacteria
CX649_08085	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CX649_08090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CX649_08095	COG4838	Belongs to the UPF0358 family
CX649_08100	COG0772	Belongs to the SEDS family
CX649_08105	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CX649_08110	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CX649_08120	COG0328	RNA-DNA hybrid ribonuclease activity
CX649_08135	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CX649_08140	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CX649_08145	COG0386	Belongs to the glutathione peroxidase family
CX649_08150	COG1413	lyase activity
CX649_08165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CX649_08170	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CX649_08175	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CX649_08180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CX649_08190	COG1307	EDD domain protein, DegV family
CX649_08195	COG1999	signal sequence binding
CX649_08200	COG2755	lipolytic protein G-D-S-L family
CX649_08205	COG4698	Protein conserved in bacteria
CX649_08210	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CX649_08210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CX649_08220	COG2814	Major facilitator Superfamily
CX649_08225	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CX649_08225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CX649_08240	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CX649_08245	COG4479	Belongs to the UPF0346 family
CX649_08265	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CX649_08320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CX649_08335	COG2323	membrane
CX649_08340	COG3118	belongs to the thioredoxin family
CX649_08340	COG0492	ferredoxin-NADP+ reductase activity
CX649_08355	COG0129	dihydroxy-acid dehydratase activity
CX649_08360	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CX649_08370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CX649_08380	COG1028	Short-chain dehydrogenase reductase Sdr
CX649_08385	COG0534	Mate efflux family protein
CX649_08395	COG0477	Major facilitator Superfamily
CX649_08400	COG1309	transcriptional regulator
CX649_08405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CX649_08430	COG0840	transmembrane signaling receptor activity
CX649_08450	COG1012	belongs to the aldehyde dehydrogenase family
CX649_08455	COG1937	Protein conserved in bacteria
CX649_08465	COG2608	mercury ion transmembrane transporter activity
CX649_08490	COG1566	PFAM secretion protein HlyD family protein
CX649_08495	COG2814	Major facilitator Superfamily
CX649_08505	COG0039	L-malate dehydrogenase activity
CX649_08510	COG2258	MOSC domain
CX649_08525	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CX649_08530	COG2079	MmgE PrpD family protein
CX649_08535	COG0372	Belongs to the citrate synthase family
CX649_08545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CX649_08550	COG0667	Aldo Keto reductase
CX649_08555	COG0723	plastoquinol--plastocyanin reductase activity
CX649_08555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CX649_08560	COG3275	phosphorelay sensor kinase activity
CX649_08570	COG1966	Carbon starvation protein
CX649_08575	COG1309	transcriptional regulator
CX649_08580	COG0673	inositol 2-dehydrogenase activity
CX649_08585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CX649_08605	COG3226	Transcriptional regulator
CX649_08615	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CX649_08635	COG1846	Transcriptional regulator
CX649_08640	COG1033	growth of symbiont in host cell
CX649_08640	COG2409	Drug exporters of the RND superfamily
CX649_08645	COG1024	Enoyl-CoA hydratase
CX649_08650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CX649_08655	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CX649_08660	COG4149	molybdate abc transporter
CX649_08665	COG1910	domain protein
CX649_08675	COG0725	ABC transporter, periplasmic molybdate-binding protein
CX649_08685	COG1028	Short-chain dehydrogenase reductase Sdr
CX649_08690	COG3586	endonuclease activity
CX649_08700	COG0640	Transcriptional regulator
CX649_08705	COG0798	PFAM Bile acid sodium symporter
CX649_08710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CX649_08715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CX649_08720	COG1279	arginine transmembrane transporter activity
CX649_08725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CX649_08735	COG2226	methyltransferase
CX649_08745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CX649_08750	COG1960	acyl-CoA dehydrogenase activity
CX649_08795	COG0390	transport system, permease component
CX649_08800	COG3842	ATPase activity
CX649_08825	COG0314	molybdopterin synthase activity
CX649_08830	COG1763	Mo-molybdopterin cofactor biosynthetic process
CX649_08835	COG0303	'Molybdopterin
CX649_08840	COG0746	molybdenum cofactor guanylyltransferase activity
CX649_08880	COG2151	metal-sulfur cluster biosynthetic enzyme
CX649_08890	COG0535	radical SAM domain protein
CX649_08895	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CX649_08910	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CX649_08935	COG0174	glutamine synthetase
CX649_08940	COG0789	Transcriptional regulator
CX649_08950	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CX649_08955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CX649_08960	COG0464	growth
CX649_08965	COG1923	regulation of RNA biosynthetic process
CX649_08970	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CX649_08975	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CX649_08980	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CX649_08990	COG4550	Control of competence regulator ComK, YlbF/YmcA
CX649_08995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CX649_09035	COG2195	Cleaves the N-terminal amino acid of tripeptides
CX649_09095	COG1013	pyruvate-flavodoxin oxidoreductase activity
CX649_09100	COG0674	pyruvate-flavodoxin oxidoreductase activity
CX649_09100	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CX649_09105	COG2359	stage V sporulation protein S
CX649_09115	COG1692	metallophosphoesterase
CX649_09120	COG1418	mRNA catabolic process
CX649_09125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CX649_09130	COG1546	Belongs to the CinA family
CX649_09130	COG1058	Belongs to the CinA family
CX649_09135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CX649_09140	COG1426	Protein conserved in bacteria
CX649_09155	COG0300	oxidoreductase activity
CX649_09160	COG0612	Peptidase, M16
CX649_09165	COG0612	Peptidase, M16
CX649_09180	COG4980	gas vesicle protein
CX649_09180	COG1674	ftsk spoiiie
CX649_09190	COG0740	serine-type endopeptidase activity
CX649_09195	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CX649_09200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CX649_09205	COG0527	aspartate kinase activity
CX649_09210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CX649_09215	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CX649_09220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CX649_09225	COG1873	PFAM PRC-barrel domain
CX649_09230	COG0612	Peptidase, M16
CX649_09235	COG0726	polysaccharide deacetylase
CX649_09240	COG1185	polyribonucleotide nucleotidyltransferase activity
CX649_09245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CX649_09250	COG0196	riboflavin kinase activity
CX649_09255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CX649_09260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CX649_09265	COG1550	Protein conserved in bacteria
CX649_09270	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CX649_09275	COG1358	cellular component organization or biogenesis
CX649_09280	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CX649_09285	COG0195	Participates in both transcription termination and antitermination
CX649_09290	COG0779	Required for maturation of 30S ribosomal subunits
CX649_09295	COG2176	DNA-directed DNA polymerase activity
CX649_09300	COG0442	prolyl-tRNA aminoacylation
CX649_09305	COG0750	zinc metalloprotease
CX649_09310	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CX649_09315	COG4589	Belongs to the CDS family
CX649_09320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CX649_09325	COG0233	cytoplasmic translational termination
CX649_09330	COG0528	UMP kinase activity
CX649_09335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CX649_09340	COG0052	Belongs to the universal ribosomal protein uS2 family
CX649_09350	COG1191	sigma factor activity
CX649_09355	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CX649_09360	COG1776	CheC inhibitor of MCP methylation
CX649_09365	COG0835	chemotaxis
CX649_09370	COG2198	Histidine kinase
CX649_09370	COG0643	Histidine kinase
CX649_09375	COG2201	protein-glutamate methylesterase activity
CX649_09380	COG0455	bacterial-type flagellum organization
CX649_09385	COG1419	protein localization to endoplasmic reticulum
CX649_09390	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CX649_09395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CX649_09400	COG1684	flagellar biosynthetic protein fliR
CX649_09405	COG1987	bacterial-type flagellum assembly
CX649_09410	COG1338	Plays a role in the flagellum-specific transport system
CX649_09415	COG3190	flagellar
CX649_09420	COG2201	protein-glutamate methylesterase activity
CX649_09425	COG1776	CheC inhibitor of MCP methylation
CX649_09425	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CX649_09430	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CX649_09435	COG1580	Controls the rotational direction of flagella during chemotaxis
CX649_09440	COG1582	Flagellar protein (FlbD)
CX649_09445	COG4786	Flagellar basal body rod
CX649_09450	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CX649_09455	COG3144	bacterial-type flagellum assembly
CX649_09465	COG2882	bacterial-type flagellum organization
CX649_09470	COG1157	protein secretion by the type III secretion system
CX649_09475	COG1317	bacterial-type flagellum organization
CX649_09480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CX649_09485	COG1766	The M ring may be actively involved in energy transduction
CX649_09490	COG1677	Flagellar hook-basal body complex protein FliE
CX649_09495	COG1558	bacterial-type flagellum-dependent cell motility
CX649_09500	COG1815	bacterial-type flagellum-dependent cell motility
CX649_09505	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CX649_09510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CX649_09515	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CX649_09520	COG4974	Belongs to the 'phage' integrase family
CX649_09525	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CX649_09530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CX649_09535	COG0758	DNA mediated transformation
CX649_09540	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CX649_09545	COG0045	succinate-CoA ligase (ADP-forming) activity
CX649_09550	COG2257	FlhB HrpN YscU SpaS Family
CX649_09560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CX649_09575	COG0335	large ribosomal subunit rRNA binding
CX649_09585	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CX649_09600	COG1837	Belongs to the UPF0109 family
CX649_09605	COG0228	four-way junction DNA binding
CX649_09610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CX649_09615	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CX649_09620	COG0552	protein localization to endoplasmic reticulum
CX649_09625	COG1196	nuclear chromosome segregation
CX649_09630	COG0571	ribonuclease III activity
CX649_09635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CX649_09640	COG1028	Short-chain dehydrogenase reductase Sdr
CX649_09645	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CX649_09650	COG0416	fatty acid biosynthetic process
CX649_09655	COG1349	DNA-binding transcription factor activity
CX649_09660	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CX649_09665	COG1461	Dihydroxyacetone kinase
CX649_09670	COG1302	Protein conserved in bacteria
CX649_09675	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CX649_09685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CX649_09695	COG0515	serine threonine protein kinase
CX649_09695	COG2815	serine threonine protein kinase
CX649_09700	COG0631	protein serine/threonine phosphatase activity
CX649_09710	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CX649_09710	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CX649_09720	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CX649_09725	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CX649_09730	COG1758	RNA polymerase activity
CX649_09735	COG0194	GDP metabolic process
CX649_09740	COG2052	Domain of unknown function (DUF370)
CX649_09745	COG1561	YicC-like family, N-terminal region
CX649_09750	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CX649_09760	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CX649_09765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CX649_09775	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CX649_09780	COG0529	Catalyzes the synthesis of activated sulfate
CX649_09785	COG2046	Belongs to the sulfate adenylyltransferase family
CX649_09790	COG0175	sulfate reduction
CX649_09795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CX649_09800	COG0284	orotidine-5'-phosphate decarboxylase activity
CX649_09805	COG0167	dihydroorotate dehydrogenase activity
CX649_09810	COG0543	2 iron, 2 sulfur cluster binding
CX649_09815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CX649_09830	COG0540	Belongs to the ATCase OTCase family
CX649_09845	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CX649_09850	COG0564	pseudouridine synthase activity
CX649_09855	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CX649_09860	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CX649_09865	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CX649_09870	COG3599	regulation of cell shape
CX649_09875	COG2302	S4 RNA-binding domain
CX649_09880	COG0762	integral membrane protein
CX649_09885	COG1799	cell septum assembly
CX649_09890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CX649_09900	COG1873	PFAM PRC-barrel domain
CX649_09905	COG1191	sigma factor activity
CX649_09910	COG1191	sigma factor activity
CX649_09920	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CX649_09925	COG0849	cell division
CX649_09930	COG3856	small basic protein
CX649_09935	COG3879	Bacterial protein of unknown function (DUF881)
CX649_09940	COG3879	Bacterial protein of unknown function (DUF881)
CX649_09945	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CX649_09950	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CX649_09955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CX649_09960	COG0772	Belongs to the SEDS family
CX649_09965	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CX649_09970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CX649_09975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CX649_09980	COG0768	penicillin binding
CX649_09990	COG4839	cell division protein FtsL
CX649_09995	COG0275	rRNA processing
CX649_10000	COG2001	Belongs to the MraZ family
CX649_10005	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
CX649_10015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CX649_10020	COG0454	-acetyltransferase
CX649_10035	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CX649_10040	COG1399	metal-binding, possibly nucleic acid-binding protein
CX649_10045	COG1323	Belongs to the UPF0348 family
CX649_10050	COG3480	Lon protease (S16) C-terminal proteolytic domain
CX649_10055	COG1752	Esterase of the alpha-beta hydrolase superfamily
CX649_10060	COG3314	Sporulation integral membrane protein YlbJ
CX649_10065	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CX649_10070	COG0742	ribosomal rna small subunit methyltransferase
CX649_10085	COG4471	UPF0298 protein
CX649_10090	COG3679	Belongs to the UPF0342 family
CX649_10110	COG2340	Cysteine-rich secretory protein family
CX649_10115	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CX649_10125	COG3336	cytochrome c oxidase
CX649_10130	COG3359	exonuclease
CX649_10135	COG1205	dead DEAH box helicase
CX649_10135	COG1111	helicase
CX649_10170	COG3331	DNA recombination
CX649_10175	COG4499	WXG100 protein secretion system (Wss), protein YukC
CX649_10175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CX649_10185	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CX649_10190	COG3935	DnaD domain protein
CX649_10195	COG0017	Asparaginyl-tRNA synthetase
CX649_10200	COG0436	Aminotransferase
CX649_10220	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CX649_10225	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CX649_10240	COG0617	tRNA 3'-terminal CCA addition
CX649_10245	COG0438	transferase activity, transferring glycosyl groups
CX649_10250	COG1803	Methylglyoxal synthase
CX649_10255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CX649_10260	COG1694	Mazg nucleotide pyrophosphohydrolase
CX649_10265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CX649_10275	COG4347	Protein of unknown function (DUF1405)
CX649_10290	COG1115	amino acid carrier protein
CX649_10295	COG2010	Cytochrome c
CX649_10295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CX649_10300	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CX649_10315	COG5582	Belongs to the UPF0302 family
CX649_10320	COG0457	Tetratricopeptide repeat
CX649_10335	COG0287	Prephenate dehydrogenase
CX649_10345	COG0159	tryptophan synthase activity
CX649_10355	COG0135	phosphoribosylanthranilate isomerase activity
CX649_10360	COG0134	indole-3-glycerol-phosphate synthase activity
CX649_10365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CX649_10375	COG4401	Chorismate mutase type I
CX649_10380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CX649_10395	COG0105	UTP biosynthetic process
CX649_10400	COG0142	geranyltranstransferase activity
CX649_10405	COG2226	methyltransferase
CX649_10410	COG0142	geranyltranstransferase activity
CX649_10420	COG0302	gtp cyclohydrolase
CX649_10425	COG0776	regulation of translation
CX649_10435	COG5337	Spore coat protein CotH
CX649_10450	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CX649_10455	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CX649_10475	COG1160	GTP binding
CX649_10495	COG0539	negative regulation of cytoplasmic translation
CX649_10500	COG0204	Acyl-transferase
CX649_10505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CX649_10510	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CX649_10515	COG2959	enzyme of heme biosynthesis
CX649_10520	COG3773	Cell wall hydrolase
CX649_10520	COG3409	Peptidoglycan-binding domain 1 protein
CX649_10525	COG2339	peptidase activity
CX649_10535	COG0492	ferredoxin-NADP+ reductase activity
CX649_10540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CX649_10545	COG4862	establishment of competence for transformation
CX649_10555	COG1388	LysM domain
CX649_10560	COG1266	CAAX protease self-immunity
CX649_10565	COG0514	ATP-dependent DNA helicase (RecQ)
CX649_10570	COG4955	Helix-turn-helix domain
CX649_10580	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CX649_10590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CX649_10600	COG1595	DNA-templated transcription, initiation
CX649_10605	COG2096	Adenosyltransferase
CX649_10610	COG5002	protein histidine kinase activity
CX649_10615	COG0745	RESPONSE REGULATOR receiver
CX649_10620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CX649_10625	COG1333	cytochrome c biogenesis protein
CX649_10630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CX649_10635	COG1187	pseudouridine synthase activity
CX649_10640	COG0700	Nucleoside recognition
CX649_10645	COG2715	membrane protein required for spore maturation
CX649_10650	COG1686	Belongs to the peptidase S11 family
CX649_10655	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CX649_10660	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CX649_10665	COG1547	Domain of unknown function (DUF309)
CX649_10670	COG1254	Belongs to the acylphosphatase family
CX649_10680	COG4214	carbohydrate transport
CX649_10685	COG1129	ABC transporter
CX649_10690	COG4213	ABC transporter substrate-binding protein
CX649_10695	COG3279	Response regulator of the LytR AlgR family
CX649_10700	COG2972	Histidine kinase
CX649_10710	COG1657	PFAM Prenyltransferase squalene oxidase
CX649_10740	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CX649_10745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CX649_10750	COG0493	'glutamate synthase
CX649_10755	COG0069	glutamate synthase activity
CX649_10755	COG0067	glutamate synthase
CX649_10755	COG0070	glutamate synthase
CX649_10760	COG0583	DNA-binding transcription factor activity
CX649_10765	COG2195	Cleaves the N-terminal amino acid of tripeptides
CX649_10770	COG4129	membrane
CX649_10780	COG0508	dehydrogenase complex catalyzes the overall conversion of
CX649_10785	COG0022	dehydrogenase e1 component
CX649_10790	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CX649_10795	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CX649_10805	COG0745	RESPONSE REGULATOR receiver
CX649_10810	COG0750	zinc metalloprotease
CX649_10815	COG0497	DNA recombination
CX649_10820	COG1438	arginine binding
CX649_10825	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CX649_10830	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CX649_10840	COG0142	geranyltranstransferase activity
CX649_10845	COG1722	exodeoxyribonuclease VII activity
CX649_10850	COG1570	exodeoxyribonuclease VII activity
CX649_10855	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CX649_10865	COG1302	Protein conserved in bacteria
CX649_10870	COG0439	Biotin carboxylase
CX649_10875	COG0511	ligase activity, forming carbon-carbon bonds
CX649_10915	COG3854	ATPases associated with a variety of cellular activities
CX649_10920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CX649_10925	COG0006	proline dipeptidase activity
CX649_10940	COG3872	metal-dependent enzyme
CX649_10950	COG1752	Esterase of the alpha-beta hydrolase superfamily
CX649_10955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CX649_10960	COG0095	Lipoate-protein ligase
CX649_10965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CX649_10970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CX649_10975	COG0095	Lipoate-protein ligase
CX649_10980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CX649_10985	COG0751	glycine-tRNA ligase activity
CX649_10990	COG0752	glycyl-tRNA synthetase alpha subunit
CX649_10995	COG1381	Involved in DNA repair and RecF pathway recombination
CX649_11005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CX649_11010	COG0295	cytidine deaminase activity
CX649_11015	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CX649_11025	COG1480	7TM receptor with intracellular HD hydrolase
CX649_11030	COG1702	phosphate starvation-inducible protein PhoH
CX649_11050	COG4864	UPF0365 protein
CX649_11055	COG1030	water channel activity
CX649_11060	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CX649_11065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CX649_11070	COG0726	polysaccharide deacetylase
CX649_11075	COG1610	YqeY-like protein
CX649_11080	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CX649_11085	COG1283	sodium-dependent phosphate transmembrane transporter activity
CX649_11090	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CX649_11095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CX649_11100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CX649_11105	COG2264	protein methyltransferase activity
CX649_11110	COG0484	heat shock protein binding
CX649_11115	COG0443	Heat shock 70 kDa protein
CX649_11125	COG1420	regulation of RNA biosynthetic process
CX649_11130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CX649_11135	COG0481	GTPase activity
CX649_11145	COG0860	N-Acetylmuramoyl-L-alanine amidase
CX649_11155	COG0268	Binds directly to 16S ribosomal RNA
CX649_11160	COG1466	dna polymerase III delta subunit
CX649_11170	COG2333	competence protein COMEC
CX649_11170	COG0658	competence protein
CX649_11175	COG2131	deaminase
CX649_11180	COG1555	photosystem II stabilization
CX649_11180	COG1596	polysaccharide export
CX649_11185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CX649_11190	COG2226	methyltransferase
CX649_11195	COG0799	negative regulation of ribosome biogenesis
CX649_11200	COG1713	HD superfamily hydrolase involved in NAD metabolism
CX649_11205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CX649_11210	COG1534	Rna-binding protein
CX649_11220	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CX649_11225	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CX649_11245	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CX649_11255	COG0768	penicillin binding
CX649_11260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CX649_11280	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CX649_11285	COG3906	Belongs to the UPF0473 family
CX649_11290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CX649_11300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CX649_11305	COG0628	permease
CX649_11315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CX649_11325	COG0482	sulfurtransferase activity
CX649_11330	COG1104	cysteine desulfurase activity
CX649_11335	COG1959	2 iron, 2 sulfur cluster binding
CX649_11340	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CX649_11345	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CX649_11355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CX649_11360	COG0124	histidyl-tRNA synthetase
CX649_11365	COG4991	sh3 domain protein
CX649_11365	COG3103	Sh3 type 3 domain protein
CX649_11365	COG0860	N-Acetylmuramoyl-L-alanine amidase
CX649_11370	COG1490	D-aminoacyl-tRNA deacylase activity
CX649_11375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CX649_11380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CX649_11385	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CX649_11385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CX649_11390	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CX649_11390	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CX649_11400	COG2244	polysaccharide biosynthetic process
CX649_11410	COG1862	Preprotein translocase
CX649_11415	COG0343	queuine tRNA-ribosyltransferase activity
CX649_11420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CX649_11430	COG2255	four-way junction helicase activity
CX649_11435	COG0632	four-way junction helicase activity
CX649_11445	COG0217	transcriptional regulatory protein
CX649_11455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CX649_11460	COG1388	LysM domain
CX649_11465	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CX649_11470	COG0157	Belongs to the NadC ModD family
CX649_11475	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CX649_11480	COG1104	cysteine desulfurase activity
CX649_11485	COG1827	regulation of RNA biosynthetic process
CX649_11490	COG0077	Prephenate dehydratase
CX649_11495	COG4492	Belongs to the UPF0735 family
CX649_11500	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CX649_11505	COG3290	protein histidine kinase activity
CX649_11510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CX649_11515	COG2868	ribosomal protein
CX649_11520	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CX649_11525	COG1530	ribonuclease E activity
CX649_11530	COG1994	Peptidase M50
CX649_11535	COG0739	heme binding
CX649_11540	COG1914	H( )-stimulated, divalent metal cation uptake system
CX649_11545	COG0778	Nitroreductase
CX649_11555	COG2894	cell division
CX649_11560	COG0850	regulation of cytokinetic process
CX649_11565	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
CX649_11570	COG1792	Involved in formation and maintenance of cell shape
CX649_11575	COG1077	Cell shape determining protein MreB Mrl
CX649_11580	COG2003	Belongs to the UPF0758 family
CX649_11595	COG0285	dihydrofolate synthase activity
CX649_11615	COG1388	LysM domain
CX649_11620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CX649_11625	COG0113	porphobilinogen synthase activity
CX649_11630	COG1587	Uroporphyrinogen-III synthase
CX649_11635	COG0181	hydroxymethylbilane synthase activity
CX649_11640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CX649_11655	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CX649_11660	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CX649_11665	COG0470	DNA polymerase III
CX649_11665	COG1067	ATP-dependent peptidase activity
CX649_11670	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CX649_11675	COG0544	peptidyl-prolyl cis-trans isomerase activity
CX649_11680	COG0457	Tetratricopeptide repeat
CX649_11680	COG1477	protein flavinylation
CX649_11685	COG0066	3-isopropylmalate dehydratase activity
CX649_11690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CX649_11695	COG0473	3-isopropylmalate dehydrogenase activity
CX649_11700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CX649_11705	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CX649_11710	COG0440	acetolactate synthase activity
CX649_11715	COG0028	Belongs to the TPP enzyme family
CX649_11720	COG2315	Protein conserved in bacteria
CX649_11735	COG0622	Phosphoesterase
CX649_11740	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CX649_11745	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CX649_11750	COG5401	PFAM Sporulation and spore germination
CX649_11755	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CX649_11760	COG1846	Transcriptional regulator
CX649_11765	COG2197	response regulator
CX649_11770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CX649_11775	COG1053	succinate dehydrogenase
CX649_11780	COG2009	succinate dehydrogenase
CX649_11785	COG1719	4-vinyl reductase, 4VR
CX649_11790	COG0322	excinuclease ABC activity
CX649_11795	COG3118	belongs to the thioredoxin family
CX649_11800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CX649_11805	COG2086	electron transfer activity
CX649_11810	COG1309	transcriptional regulator
CX649_11815	COG0318	PFAM AMP-dependent synthetase and ligase
CX649_11820	COG3766	membrane
CX649_11825	COG1193	negative regulation of DNA recombination
CX649_11830	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CX649_11830	COG1796	DNA polymerase
CX649_11835	COG1286	toxin biosynthetic process
CX649_11840	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CX649_11850	COG0072	phenylalanine-tRNA ligase activity
CX649_11850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CX649_11855	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CX649_11865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CX649_11875	COG1363	Peptidase, m42
CX649_11895	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CX649_11900	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CX649_11905	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CX649_11915	COG5146	pantothenate kinase activity
CX649_11920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CX649_11930	COG1484	DNA-dependent DNA replication
CX649_11935	COG3611	Membrane attachment protein
CX649_11940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CX649_11945	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CX649_11950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CX649_11960	COG1971	Probably functions as a manganese efflux pump
CX649_11965	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CX649_11970	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CX649_11970	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CX649_11975	COG0330	HflC and HflK could
CX649_11980	COG0330	HflC and HflK could
CX649_11985	COG5002	protein histidine kinase activity
CX649_11990	COG0745	RESPONSE REGULATOR receiver
CX649_12000	COG0538	isocitrate dehydrogenase activity
CX649_12005	COG0372	Belongs to the citrate synthase family
CX649_12010	COG3030	protein affecting phage T7 exclusion by the F plasmid
CX649_12020	COG0205	6-phosphofructokinase activity
CX649_12025	COG0825	malonyl-CoA metabolic process
CX649_12030	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CX649_12035	COG0281	malic enzyme
CX649_12050	COG0622	Phosphoesterase
CX649_12055	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CX649_12060	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CX649_12065	COG5401	PFAM Sporulation and spore germination
CX649_12070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CX649_12075	COG1846	Transcriptional regulator
CX649_12080	COG2197	response regulator
CX649_12085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CX649_12090	COG1053	succinate dehydrogenase
CX649_12095	COG2009	succinate dehydrogenase
CX649_12100	COG1719	4-vinyl reductase, 4VR
CX649_12105	COG0322	excinuclease ABC activity
CX649_12110	COG3118	belongs to the thioredoxin family
CX649_12115	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CX649_12120	COG2086	electron transfer activity
CX649_12125	COG1309	transcriptional regulator
CX649_12130	COG0318	PFAM AMP-dependent synthetase and ligase
CX649_12135	COG3766	membrane
CX649_12140	COG1193	negative regulation of DNA recombination
CX649_12145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CX649_12145	COG1796	DNA polymerase
CX649_12150	COG1286	toxin biosynthetic process
CX649_12155	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CX649_12165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CX649_12165	COG0072	phenylalanine-tRNA ligase activity
CX649_12170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CX649_12180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CX649_12190	COG1363	Peptidase, m42
CX649_12210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CX649_12215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CX649_12220	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CX649_12230	COG5146	pantothenate kinase activity
CX649_12235	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CX649_12245	COG1484	DNA-dependent DNA replication
CX649_12250	COG3611	Membrane attachment protein
CX649_12255	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CX649_12260	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CX649_12265	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CX649_12275	COG1971	Probably functions as a manganese efflux pump
CX649_12280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CX649_12285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CX649_12285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CX649_12290	COG0330	HflC and HflK could
CX649_12295	COG0330	HflC and HflK could
CX649_12300	COG5002	protein histidine kinase activity
CX649_12305	COG0745	RESPONSE REGULATOR receiver
CX649_12315	COG0538	isocitrate dehydrogenase activity
CX649_12320	COG0372	Belongs to the citrate synthase family
CX649_12325	COG3030	protein affecting phage T7 exclusion by the F plasmid
CX649_12335	COG0205	6-phosphofructokinase activity
CX649_12340	COG0825	malonyl-CoA metabolic process
CX649_12345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CX649_12350	COG0281	malic enzyme