locus-tag	class	description
L2D31_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
L2D31_00010	COG0592	DNA-directed DNA polymerase activity
L2D31_00015	COG2501	S4 domain
L2D31_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
L2D31_00030	COG0187	DNA topoisomerase II activity
L2D31_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L2D31_00070	COG0516	GMP reductase activity
L2D31_00070	COG0517	IMP dehydrogenase activity
L2D31_00075	COG1686	Belongs to the peptidase S11 family
L2D31_00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2D31_00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
L2D31_00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
L2D31_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
L2D31_00110	COG1428	Deoxynucleoside kinase
L2D31_00115	COG1428	Deoxynucleoside kinase
L2D31_00120	COG3858	chitin binding
L2D31_00120	COG1388	LysM domain
L2D31_00125	COG1335	isochorismatase
L2D31_00130	COG0590	tRNA wobble adenosine to inosine editing
L2D31_00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
L2D31_00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
L2D31_00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
L2D31_00195	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
L2D31_00200	COG3853	Toxic anion resistance protein (TelA)
L2D31_00205	COG1982	Orn Lys Arg decarboxylase major
L2D31_00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
L2D31_00215	COG3870	Protein conserved in bacteria
L2D31_00220	COG1728	Protein conserved in bacteria
L2D31_00225	COG0470	DNA polymerase III
L2D31_00230	COG1774	PSP1 C-terminal conserved region
L2D31_00235	COG4467	Involved in initiation control of chromosome replication
L2D31_00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
L2D31_00245	COG2827	Endonuclease containing a URI domain
L2D31_00250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
L2D31_00255	COG2002	toxin-antitoxin pair type II binding
L2D31_00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2D31_00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2D31_00265	COG0084	hydrolase, TatD family'
L2D31_00270	COG3583	domain protein
L2D31_00270	COG3584	3D domain protein
L2D31_00275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L2D31_00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
L2D31_00290	COG4466	Protein conserved in bacteria
L2D31_00300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
L2D31_00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L2D31_00310	COG0251	oxidation-reduction process
L2D31_00315	COG2088	sporulation resulting in formation of a cellular spore
L2D31_00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
L2D31_00330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
L2D31_00335	COG0193	aminoacyl-tRNA hydrolase activity
L2D31_00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
L2D31_00350	COG2002	toxin-antitoxin pair type II binding
L2D31_00355	COG2244	polysaccharide biosynthetic process
L2D31_00360	COG3956	TIGRFAM MazG family protein
L2D31_00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
L2D31_00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
L2D31_00385	COG1098	S1 RNA binding domain
L2D31_00400	COG2208	phosphoserine phosphatase activity
L2D31_00405	COG2304	oxidoreductase activity
L2D31_00410	COG0515	serine threonine protein kinase
L2D31_00415	COG0037	tRNA processing
L2D31_00420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
L2D31_00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
L2D31_00430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
L2D31_00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
L2D31_00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2D31_00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2D31_00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
L2D31_00455	COG0512	Glutamine amidotransferase of anthranilate synthase
L2D31_00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2D31_00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
L2D31_00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
L2D31_00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
L2D31_00480	COG1396	sequence-specific DNA binding
L2D31_00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2D31_00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
L2D31_00570	COG4463	regulation of RNA biosynthetic process
L2D31_00575	COG3880	PFAM UvrB UvrC protein
L2D31_00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
L2D31_00585	COG0542	response to heat
L2D31_00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
L2D31_00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
L2D31_00600	COG4956	integral membrane protein (PIN domain superfamily)
L2D31_00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
L2D31_00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
L2D31_00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
L2D31_00620	COG1045	serine acetyltransferase
L2D31_00625	COG0215	cysteine-tRNA ligase activity
L2D31_00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
L2D31_00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2D31_00640	COG3688	RNA-binding protein containing a PIN domain
L2D31_00645	COG1595	DNA-templated transcription, initiation
L2D31_00650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L2D31_00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L2D31_00660	COG0250	Participates in transcription elongation, termination and antitermination
L2D31_00670	COG0081	regulation of translation
L2D31_00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
L2D31_00680	COG0222	ribosome binding
L2D31_00685	COG2813	Specifically methylates the guanine in position
L2D31_00690	COG0085	RNA polymerase activity
L2D31_00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
L2D31_00700	COG1358	cellular component organization or biogenesis
L2D31_00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
L2D31_00710	COG0049	tRNA binding
L2D31_00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
L2D31_00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
L2D31_00725	COG0596	Alpha beta hydrolase
L2D31_00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
L2D31_00740	COG0088	Forms part of the polypeptide exit tunnel
L2D31_00745	COG0089	rRNA binding
L2D31_00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
L2D31_00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
L2D31_00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
L2D31_00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
L2D31_00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
L2D31_00775	COG0255	Belongs to the universal ribosomal protein uL29 family
L2D31_00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
L2D31_00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
L2D31_00790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
L2D31_00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
L2D31_00800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L2D31_00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
L2D31_00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
L2D31_00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
L2D31_00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
L2D31_00825	COG1841	ribosomal large subunit assembly
L2D31_00830	COG0200	Binds to the 23S rRNA
L2D31_00835	COG0201	protein transport
L2D31_00840	COG0563	adenylate kinase activity
L2D31_00845	COG0024	Methionine aminopeptidase
L2D31_00855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
L2D31_00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
L2D31_00865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
L2D31_00870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
L2D31_00875	COG0202	RNA polymerase activity
L2D31_00880	COG0203	ribosomal protein L17
L2D31_00885	COG1122	ATPase activity
L2D31_00890	COG1122	ATPase activity
L2D31_00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L2D31_00900	COG0101	tRNA pseudouridine synthase activity
L2D31_00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
L2D31_00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
L2D31_00915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2D31_00945	COG0860	N-Acetylmuramoyl-L-alanine amidase
L2D31_00950	COG0489	protein tyrosine kinase activity
L2D31_00960	COG2194	sulfuric ester hydrolase activity
L2D31_00965	COG0726	polysaccharide deacetylase
L2D31_00995	COG0659	secondary active sulfate transmembrane transporter activity
L2D31_01000	COG0385	Bile acid
L2D31_01005	COG3876	Protein conserved in bacteria
L2D31_01010	COG1472	Belongs to the glycosyl hydrolase 3 family
L2D31_01015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
L2D31_01020	COG1263	PTS System
L2D31_01020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2D31_01025	COG1737	Transcriptional regulator
L2D31_01030	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
L2D31_01065	COG1595	DNA-templated transcription, initiation
L2D31_01070	COG5662	AntiSigma factor
L2D31_01075	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L2D31_01080	COG4856	YbbR-like protein
L2D31_01085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2D31_01090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
L2D31_01105	COG1131	(ABC) transporter
L2D31_01115	COG1136	(ABC) transporter
L2D31_01140	COG0535	radical SAM domain protein
L2D31_01145	COG1266	CAAX protease self-immunity
L2D31_01150	COG1131	(ABC) transporter
L2D31_01160	COG1413	lyase activity
L2D31_01165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2D31_01180	COG2311	Membrane
L2D31_01200	COG1476	TRANSCRIPTIONal
L2D31_01210	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
L2D31_01215	COG2207	Transcriptional regulator
L2D31_01220	COG1309	transcriptional regulator
L2D31_01235	COG1113	amino acid transport
L2D31_01240	COG0584	glycerophosphoryl diester phosphodiesterase
L2D31_01245	COG2271	Major facilitator Superfamily
L2D31_01255	COG1331	Highly conserved protein containing a thioredoxin domain
L2D31_01270	COG0640	Transcriptional regulator
L2D31_01285	COG1937	Protein conserved in bacteria
L2D31_01290	COG2210	Belongs to the sulfur carrier protein TusA family
L2D31_01300	COG0425	Belongs to the sulfur carrier protein TusA family
L2D31_01300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L2D31_01305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L2D31_01305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2D31_01310	COG0425	Belongs to the sulfur carrier protein TusA family
L2D31_01315	COG0730	response to heat
L2D31_01325	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L2D31_01330	COG2814	Major facilitator Superfamily
L2D31_01345	COG1846	Transcriptional regulator
L2D31_01350	COG1683	Conserved Protein
L2D31_01355	COG0656	L-ascorbic acid biosynthetic process
L2D31_01360	COG0371	Dehydrogenase
L2D31_01365	COG1054	Belongs to the UPF0176 family
L2D31_01370	COG0531	amino acid
L2D31_01380	COG3711	transcriptional antiterminator
L2D31_01385	COG2190	(PTS) system
L2D31_01385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2D31_01385	COG1263	PTS System
L2D31_01390	COG2723	6-phospho-beta-galactosidase activity
L2D31_01405	COG3711	transcriptional antiterminator
L2D31_01405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2D31_01410	COG1940	carbohydrate kinase activity
L2D31_01415	COG0383	alpha-mannosidase activity
L2D31_01420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2D31_01425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2D31_01430	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2D31_01430	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2D31_01435	COG1404	Belongs to the peptidase S8 family
L2D31_01450	COG0833	amino acid
L2D31_01455	COG2040	homocysteine
L2D31_01460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L2D31_01480	COG2814	Major facilitator Superfamily
L2D31_01500	COG1404	Belongs to the peptidase S8 family
L2D31_01510	COG1309	transcriptional regulator
L2D31_01515	COG1917	Cupin 2, conserved barrel domain protein
L2D31_01520	COG1846	Transcriptional regulator
L2D31_01525	COG0318	PFAM AMP-dependent synthetase and ligase
L2D31_01530	COG0531	amino acid
L2D31_01540	COG0596	Alpha beta hydrolase
L2D31_01545	COG1115	amino acid carrier protein
L2D31_01550	COG2066	Belongs to the glutaminase family
L2D31_01555	COG4191	Histidine kinase
L2D31_01560	COG0784	Response regulator, receiver
L2D31_01565	COG3012	SEC-C Motif Domain Protein
L2D31_01565	COG1405	negative regulation of cell septum assembly
L2D31_01575	COG0667	Aldo Keto reductase
L2D31_01580	COG3290	protein histidine kinase activity
L2D31_01585	COG3279	Response regulator of the LytR AlgR family
L2D31_01590	COG4555	ABC transporter
L2D31_01595	COG1668	transmembrane transport
L2D31_01615	COG3773	Cell wall hydrolase
L2D31_01620	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_01630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2D31_01635	COG2310	stress, protein
L2D31_01640	COG2310	stress, protein
L2D31_01645	COG2310	stress, protein
L2D31_01650	COG0861	Integral membrane protein TerC family
L2D31_01680	COG3853	Toxic anion resistance protein (TelA)
L2D31_01685	COG4175	Glycine betaine
L2D31_01685	COG0517	IMP dehydrogenase activity
L2D31_01690	COG4176	ABC-type proline glycine betaine transport system permease component
L2D31_01695	COG2113	Glycine betaine
L2D31_01710	COG1473	amidohydrolase
L2D31_01715	COG1288	antiporter activity
L2D31_01720	COG0039	L-malate dehydrogenase activity
L2D31_01725	COG1620	l-lactate permease
L2D31_01730	COG1609	Transcriptional regulator
L2D31_01735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L2D31_01740	COG0561	phosphatase activity
L2D31_01745	COG0673	inositol 2-dehydrogenase activity
L2D31_01750	COG0738	Major facilitator superfamily
L2D31_01755	COG1280	lysine exporter protein (LysE YggA)
L2D31_01770	COG3403	YqcI/YcgG family
L2D31_01775	COG1113	amino acid transport
L2D31_01780	COG3665	Urea carboxylase-associated protein
L2D31_01785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
L2D31_01795	COG1012	belongs to the aldehyde dehydrogenase family
L2D31_01800	COG0710	3-dehydroquinate dehydratase activity
L2D31_01805	COG0028	Belongs to the TPP enzyme family
L2D31_01815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
L2D31_01820	COG2271	Major facilitator Superfamily
L2D31_01835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
L2D31_01840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2D31_01850	COG0477	Major facilitator Superfamily
L2D31_01855	COG2226	methyltransferase
L2D31_01860	COG0583	DNA-binding transcription factor activity
L2D31_01865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2D31_01870	COG3458	cephalosporin-C deacetylase activity
L2D31_01880	COG3541	Predicted nucleotidyltransferase
L2D31_01885	COG0506	proline dehydrogenase activity
L2D31_01890	COG1012	belongs to the aldehyde dehydrogenase family
L2D31_01895	COG2508	Transcriptional regulator
L2D31_01900	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L2D31_01905	COG0765	amino acid transport
L2D31_01910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2D31_01920	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L2D31_01925	COG1522	sequence-specific DNA binding
L2D31_01930	COG2746	aminoglycoside 3-N-acetyltransferase activity
L2D31_01940	COG0840	transmembrane signaling receptor activity
L2D31_01940	COG3290	protein histidine kinase activity
L2D31_01945	COG3209	COG3209 Rhs family protein
L2D31_01965	COG3842	ATPase activity
L2D31_01970	COG1176	ABC-type spermidine putrescine transport system, permease component I
L2D31_01980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2D31_01985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2D31_01990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2D31_02005	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
L2D31_02010	COG4555	ABC transporter
L2D31_02020	COG0697	spore germination
L2D31_02025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2D31_02035	COG2364	Membrane
L2D31_02045	COG3764	Sortase (surface protein transpeptidase)
L2D31_02050	COG2002	toxin-antitoxin pair type II binding
L2D31_02055	COG1126	abc transporter atp-binding protein
L2D31_02060	COG0765	amino acid transport
L2D31_02065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2D31_02070	COG2124	cytochrome p450
L2D31_02075	COG0412	Dienelactone hydrolase
L2D31_02080	COG2814	Major facilitator Superfamily
L2D31_02090	COG0833	amino acid
L2D31_02095	COG3104	oligopeptide transport
L2D31_02100	COG5434	Belongs to the glycosyl hydrolase 28 family
L2D31_02105	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2D31_02110	COG0456	acetyltransferase
L2D31_02115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2D31_02120	COG0765	amino acid transport
L2D31_02125	COG1126	abc transporter atp-binding protein
L2D31_02130	COG1473	amidohydrolase
L2D31_02135	COG2079	MmgE PrpD family protein
L2D31_02140	COG0745	RESPONSE REGULATOR receiver
L2D31_02145	COG3850	Histidine kinase
L2D31_02145	COG5002	protein histidine kinase activity
L2D31_02150	COG1366	Belongs to the anti-sigma-factor antagonist family
L2D31_02155	COG0527	aspartate kinase activity
L2D31_02160	COG2814	Major facilitator Superfamily
L2D31_02165	COG1309	transcriptional regulator
L2D31_02175	COG0640	Transcriptional regulator
L2D31_02185	COG0583	DNA-binding transcription factor activity
L2D31_02190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2D31_02195	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
L2D31_02200	COG0531	amino acid
L2D31_02205	COG1012	belongs to the aldehyde dehydrogenase family
L2D31_02210	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2D31_02215	COG4549	nuclear export factor GLE1
L2D31_02220	COG1276	copper resistance
L2D31_02220	COG2372	response to copper ion
L2D31_02225	COG2213	PTS system mannitol-specific
L2D31_02230	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2D31_02235	COG0246	Mannitol dehydrogenase
L2D31_02240	COG0840	transmembrane signaling receptor activity
L2D31_02275	COG0346	lactoylglutathione lyase activity
L2D31_02285	COG0561	phosphatase activity
L2D31_02290	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
L2D31_02295	COG1914	H( )-stimulated, divalent metal cation uptake system
L2D31_02300	COG4336	lyase activity
L2D31_02305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
L2D31_02310	COG1984	allophanate hydrolase subunit 2
L2D31_02315	COG1414	Transcriptional regulator
L2D31_02320	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2D31_02325	COG2755	lipolytic protein G-D-S-L family
L2D31_02335	COG3711	transcriptional antiterminator
L2D31_02340	COG2226	methyltransferase
L2D31_02345	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_02350	COG3871	stress protein (general stress protein 26)
L2D31_02370	COG2814	Major facilitator Superfamily
L2D31_02375	COG1802	Transcriptional regulator
L2D31_02380	COG1917	Cupin 2, conserved barrel domain protein
L2D31_02380	COG2207	Transcriptional regulator
L2D31_02385	COG0697	spore germination
L2D31_02390	COG0473	3-isopropylmalate dehydrogenase activity
L2D31_02395	COG0551	DNA topoisomerase type I activity
L2D31_02395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L2D31_02400	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
L2D31_02405	COG3706	GGDEF domain
L2D31_02410	COG5298	Protein conserved in bacteria
L2D31_02415	COG1215	transferase activity, transferring glycosyl groups
L2D31_02425	COG0531	amino acid
L2D31_02430	COG0028	Belongs to the TPP enzyme family
L2D31_02435	COG5444	nuclease activity
L2D31_02475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2D31_02480	COG1914	H( )-stimulated, divalent metal cation uptake system
L2D31_02485	COG2261	transglycosylase associated protein
L2D31_02490	COG2217	Heavy metal translocating P-type atpase
L2D31_02495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
L2D31_02500	COG3290	protein histidine kinase activity
L2D31_02505	COG4565	transcriptional regulatory protein
L2D31_02510	COG1301	dicarboxylic acid transport
L2D31_02515	COG0628	permease
L2D31_02520	COG1301	dicarboxylic acid transport
L2D31_02525	COG1131	(ABC) transporter
L2D31_02530	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L2D31_02545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2D31_02550	COG1181	Belongs to the D-alanine--D-alanine ligase family
L2D31_02555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
L2D31_02570	COG0513	Belongs to the DEAD box helicase family
L2D31_02575	COG3402	PFAM membrane-flanked domain
L2D31_02580	COG3428	Bacterial PH domain
L2D31_02585	COG0705	Rhomboid family
L2D31_02590	COG0736	holo-[acyl-carrier-protein] synthase activity
L2D31_02595	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
L2D31_02600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2D31_02605	COG0864	Transcriptional regulator
L2D31_02610	COG2337	Toxic component of a toxin-antitoxin (TA) module
L2D31_02615	COG1366	Belongs to the anti-sigma-factor antagonist family
L2D31_02620	COG1366	Belongs to the anti-sigma-factor antagonist family
L2D31_02625	COG2172	sigma factor antagonist activity
L2D31_02630	COG2208	phosphoserine phosphatase activity
L2D31_02635	COG1366	Belongs to the anti-sigma-factor antagonist family
L2D31_02640	COG2172	sigma factor antagonist activity
L2D31_02645	COG1191	sigma factor activity
L2D31_02650	COG2208	phosphoserine phosphatase activity
L2D31_02655	COG2183	response to ionizing radiation
L2D31_02665	COG3091	SprT-like family
L2D31_02705	COG1309	transcriptional regulator
L2D31_02710	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2D31_02710	COG0596	Alpha beta hydrolase
L2D31_02715	COG1902	pentaerythritol trinitrate reductase activity
L2D31_02720	COG0300	oxidoreductase activity
L2D31_02735	COG1278	Cold shock
L2D31_02740	COG1329	Transcriptional regulator
L2D31_02745	COG1064	alcohol dehydrogenase
L2D31_02750	COG0789	Transcriptional regulator
L2D31_02770	COG0477	Major facilitator Superfamily
L2D31_02785	COG4221	oxidoreductase activity
L2D31_02795	COG0252	asparaginase activity
L2D31_02820	COG2814	Major facilitator Superfamily
L2D31_02865	COG1309	transcriptional regulator
L2D31_02870	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2D31_02875	COG1846	Transcriptional regulator
L2D31_02880	COG0778	Nitroreductase
L2D31_02895	COG1396	sequence-specific DNA binding
L2D31_02905	COG0456	acetyltransferase
L2D31_02920	COG4122	O-methyltransferase activity
L2D31_02930	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
L2D31_02935	COG0697	spore germination
L2D31_02945	COG1301	dicarboxylic acid transport
L2D31_02985	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
L2D31_02990	COG0802	atpase or kinase
L2D31_02995	COG1214	PFAM Peptidase M22, glycoprotease
L2D31_03000	COG0456	acetyltransferase
L2D31_03005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
L2D31_03010	COG0488	(ABC) transporter
L2D31_03015	COG0315	cyclic pyranopterin monophosphate synthase activity
L2D31_03020	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
L2D31_03025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
L2D31_03030	COG0805	protein transport
L2D31_03045	COG1266	CAAX protease self-immunity
L2D31_03050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
L2D31_03055	COG0459	protein refolding
L2D31_03060	COG1846	Transcriptional regulator
L2D31_03065	COG2808	Putative FMN-binding domain
L2D31_03070	COG1876	peptidase activity
L2D31_03095	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
L2D31_03100	COG0823	Involved in the tonB-independent uptake of proteins
L2D31_03110	COG2132	Multicopper oxidase
L2D31_03115	COG1113	amino acid transport
L2D31_03120	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L2D31_03125	COG0714	Associated with various cellular activities
L2D31_03130	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
L2D31_03135	COG1305	Transglutaminase-like
L2D31_03140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
L2D31_03140	COG0519	Catalyzes the synthesis of GMP from XMP
L2D31_03145	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
L2D31_03155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2D31_03210	COG2814	Major facilitator Superfamily
L2D31_03215	COG0583	DNA-binding transcription factor activity
L2D31_03220	COG2252	PERMEase
L2D31_03230	COG5583	Uncharacterized small protein (DUF2292)
L2D31_03235	COG3064	Membrane
L2D31_03240	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
L2D31_03250	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
L2D31_03255	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
L2D31_03260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
L2D31_03265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
L2D31_03270	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2D31_03275	COG0047	phosphoribosylformylglycinamidine synthase activity
L2D31_03280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
L2D31_03285	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
L2D31_03290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
L2D31_03295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
L2D31_03300	COG0138	bifunctional purine biosynthesis protein purh
L2D31_03305	COG0151	Belongs to the GarS family
L2D31_03330	COG1131	(ABC) transporter
L2D31_03345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L2D31_03350	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
L2D31_03355	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
L2D31_03360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L2D31_03370	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2D31_03375	COG4496	protein, YerC YecD
L2D31_03385	COG0069	glutamate synthase activity
L2D31_03400	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
L2D31_03405	COG0210	DNA helicase
L2D31_03410	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
L2D31_03415	COG4851	CamS sex pheromone cAM373 precursor
L2D31_03420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2D31_03425	COG1285	pathogenesis
L2D31_03430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2D31_03435	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2D31_03440	COG0154	amidase activity
L2D31_03445	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
L2D31_03450	COG1309	transcriptional regulator
L2D31_03455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2D31_03460	COG1957	nucleoside hydrolase
L2D31_03465	COG1597	lipid kinase activity
L2D31_03470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L2D31_03475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
L2D31_03490	COG1959	2 iron, 2 sulfur cluster binding
L2D31_03495	COG0492	ferredoxin-NADP+ reductase activity
L2D31_03510	COG1486	melibiose metabolic process
L2D31_03550	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
L2D31_03555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2D31_03560	COG1442	glycosyl transferase family 8
L2D31_03565	COG1216	Glycosyl transferase, family 2
L2D31_03570	COG1442	glycosyl transferase family 8
L2D31_03575	COG2223	nitrite transmembrane transporter activity
L2D31_03585	COG0471	metal ion transport
L2D31_03600	COG0071	Belongs to the small heat shock protein (HSP20) family
L2D31_03615	COG0531	amino acid
L2D31_03620	COG0457	Tetratricopeptide repeat
L2D31_03620	COG0463	Glycosyl transferase, family 2
L2D31_03625	COG0488	(ABC) transporter
L2D31_03630	COG1469	GTP cyclohydrolase I activity
L2D31_03635	COG0789	Transcriptional regulator
L2D31_03640	COG2814	Major facilitator Superfamily
L2D31_03645	COG0488	(ABC) transporter
L2D31_03650	COG0513	Belongs to the DEAD box helicase family
L2D31_03655	COG2130	NADP-dependent
L2D31_03675	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2D31_03675	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2D31_03680	COG1262	PFAM Formylglycine-generating sulfatase enzyme
L2D31_03690	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2D31_03690	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2D31_03700	COG3290	protein histidine kinase activity
L2D31_03705	COG4565	transcriptional regulatory protein
L2D31_03710	COG3181	Tripartite tricarboxylate transporter family receptor
L2D31_03715	COG2851	Citrate transporter
L2D31_03725	COG3479	Phenolic acid decarboxylase
L2D31_03730	COG1695	Transcriptional regulator
L2D31_03735	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
L2D31_03745	COG1254	Belongs to the acylphosphatase family
L2D31_03750	COG2258	MOSC domain
L2D31_03765	COG0024	Methionine aminopeptidase
L2D31_03770	COG1263	PTS System
L2D31_03770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2D31_03795	COG1368	sulfuric ester hydrolase activity
L2D31_03800	COG0076	glutamate decarboxylase activity
L2D31_03815	COG1263	PTS System
L2D31_03815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2D31_03820	COG0366	Alpha amylase catalytic
L2D31_03825	COG2188	Transcriptional regulator
L2D31_03835	COG0737	Belongs to the 5'-nucleotidase family
L2D31_03840	COG0693	protein deglycase activity
L2D31_03845	COG4840	Belongs to the UPF0435 family
L2D31_03850	COG1115	amino acid carrier protein
L2D31_03855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2D31_03860	COG4980	gas vesicle protein
L2D31_03865	COG1295	ribonuclease BN
L2D31_03870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2D31_03875	COG0477	Major facilitator Superfamily
L2D31_03885	COG0387	Pfam Sodium calcium exchanger
L2D31_03895	COG0217	transcriptional regulatory protein
L2D31_03905	COG0668	transmembrane transport
L2D31_03910	COG0535	radical SAM domain protein
L2D31_03920	COG0726	polysaccharide deacetylase
L2D31_03930	COG0598	Magnesium transport protein CorA
L2D31_03940	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
L2D31_03945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
L2D31_03960	COG0789	Transcriptional regulator
L2D31_03965	COG2814	Major facilitator Superfamily
L2D31_03980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L2D31_04025	COG2076	Multidrug Resistance protein
L2D31_04030	COG2076	Multidrug Resistance protein
L2D31_04035	COG1309	transcriptional regulator
L2D31_04045	COG4637	Psort location Cytoplasmic, score
L2D31_04050	COG2755	lipolytic protein G-D-S-L family
L2D31_04055	COG0492	ferredoxin-NADP+ reductase activity
L2D31_04060	COG2169	Transcriptional regulator
L2D31_04065	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L2D31_04070	COG1132	(ABC) transporter
L2D31_04075	COG1742	UPF0060 membrane protein
L2D31_04080	COG1595	DNA-templated transcription, initiation
L2D31_04100	COG2318	DinB family
L2D31_04110	COG1846	Transcriptional regulator
L2D31_04115	COG0392	lysyltransferase activity
L2D31_04115	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
L2D31_04135	COG0778	Nitroreductase
L2D31_04150	COG1090	epimerase
L2D31_04155	COG2137	regulation of response to DNA damage stimulus
L2D31_04180	COG0463	Glycosyl transferase, family 2
L2D31_04185	COG4485	Bacterial membrane protein, YfhO
L2D31_04190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
L2D31_04205	COG2140	Oxalate decarboxylase
L2D31_04215	COG1191	sigma factor activity
L2D31_04260	COG1988	membrane-bound metal-dependent
L2D31_04265	COG1194	a g-specific adenine glycosylase
L2D31_04275	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_04290	COG3557	Belongs to the UPF0374 family
L2D31_04295	COG1132	(ABC) transporter
L2D31_04300	COG0444	Belongs to the ABC transporter superfamily
L2D31_04305	COG4608	Belongs to the ABC transporter superfamily
L2D31_04310	COG0747	negative chemotaxis
L2D31_04315	COG0601	transmembrane transport
L2D31_04320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2D31_04325	COG4129	membrane
L2D31_04330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L2D31_04335	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2D31_04340	COG0735	belongs to the Fur family
L2D31_04485	COG1368	sulfuric ester hydrolase activity
L2D31_04490	COG0681	Belongs to the peptidase S26 family
L2D31_04495	COG2873	o-acetylhomoserine
L2D31_04505	COG1116	anion transmembrane transporter activity
L2D31_04510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2D31_04515	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2D31_04530	COG1131	(ABC) transporter
L2D31_04560	COG3382	B3 4 domain protein
L2D31_04565	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
L2D31_04575	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
L2D31_04580	COG2766	serine protein kinase
L2D31_04585	COG2718	Belongs to the UPF0229 family
L2D31_04590	COG1566	PFAM secretion protein HlyD family protein
L2D31_04595	COG2814	Major facilitator Superfamily
L2D31_04600	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2D31_04610	COG1278	Cold shock
L2D31_04615	COG3706	GGDEF domain
L2D31_04640	COG5577	PFAM Coat F domain
L2D31_04645	COG5002	protein histidine kinase activity
L2D31_04650	COG0737	Belongs to the 5'-nucleotidase family
L2D31_04650	COG1525	nuclease
L2D31_04650	COG4085	toxin activity
L2D31_04655	COG3764	Sortase (surface protein transpeptidase)
L2D31_04660	COG0564	pseudouridine synthase activity
L2D31_04670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
L2D31_04675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
L2D31_04675	COG3153	acetyltransferase
L2D31_04695	COG3835	regulator
L2D31_04700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
L2D31_04705	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
L2D31_04710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
L2D31_04715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
L2D31_04720	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
L2D31_04725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
L2D31_04730	COG4585	Histidine kinase
L2D31_04730	COG2203	Gaf domain
L2D31_04735	COG2197	response regulator
L2D31_04750	COG0753	catalase activity
L2D31_04755	COG1959	2 iron, 2 sulfur cluster binding
L2D31_04760	COG1017	nitric oxide dioxygenase activity
L2D31_04760	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
L2D31_04765	COG2719	SpoVR family
L2D31_04770	COG1785	Belongs to the alkaline phosphatase family
L2D31_04775	COG0791	NLP P60 protein
L2D31_04775	COG1388	LysM domain
L2D31_04780	COG0531	amino acid
L2D31_04795	COG1595	DNA-templated transcription, initiation
L2D31_04800	COG0204	Acyl-transferase
L2D31_04805	COG1253	flavin adenine dinucleotide binding
L2D31_04810	COG0789	Transcriptional regulator
L2D31_04815	COG1253	flavin adenine dinucleotide binding
L2D31_04830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
L2D31_04835	COG0584	glycerophosphoryl diester phosphodiesterase
L2D31_04845	COG0668	transmembrane transport
L2D31_04850	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
L2D31_04855	COG0726	polysaccharide deacetylase
L2D31_04860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2D31_04865	COG0589	response to stress
L2D31_04870	COG1132	(ABC) transporter
L2D31_04875	COG1132	(ABC) transporter
L2D31_04885	COG0702	epimerase
L2D31_04895	COG3842	ATPase activity
L2D31_04900	COG2508	Transcriptional regulator
L2D31_04910	COG0189	ligase activity
L2D31_04915	COG0189	ligase activity
L2D31_04920	COG4399	Belongs to the UPF0754 family
L2D31_04925	COG3679	Belongs to the UPF0342 family
L2D31_04930	COG0561	phosphatase activity
L2D31_04935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2D31_04945	COG0475	glutathione-regulated potassium exporter activity
L2D31_04950	COG0490	domain, Protein
L2D31_04960	COG1024	Enoyl-CoA hydratase
L2D31_04970	COG0420	3'-5' exonuclease activity
L2D31_04975	COG4717	serine-type aminopeptidase activity
L2D31_04980	COG3481	metal-dependent phosphohydrolase, HD sub domain
L2D31_04990	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
L2D31_05020	COG1846	Transcriptional regulator
L2D31_05025	COG4980	gas vesicle protein
L2D31_05040	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
L2D31_05045	COG0537	adenosine 5'-monophosphoramidase activity
L2D31_05050	COG1131	(ABC) transporter
L2D31_05055	COG4473	ABC transporter
L2D31_05065	COG1473	amidohydrolase
L2D31_05075	COG2329	Antibiotic biosynthesis monooxygenase
L2D31_05080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2D31_05085	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
L2D31_05090	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
L2D31_05095	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
L2D31_05100	COG1309	transcriptional regulator
L2D31_05105	COG1511	domain protein
L2D31_05110	COG1363	Peptidase, m42
L2D31_05115	COG1301	dicarboxylic acid transport
L2D31_05125	COG1234	tRNA 3'-trailer cleavage
L2D31_05130	COG0095	Lipoate-protein ligase
L2D31_05135	COG0318	PFAM AMP-dependent synthetase and ligase
L2D31_05145	COG0501	Belongs to the peptidase M48B family
L2D31_05150	COG1404	Belongs to the peptidase S8 family
L2D31_05155	COG0406	alpha-ribazole phosphatase activity
L2D31_05160	COG0840	transmembrane signaling receptor activity
L2D31_05165	COG0723	plastoquinol--plastocyanin reductase activity
L2D31_05165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
L2D31_05170	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_05180	COG4903	ComK protein
L2D31_05195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2D31_05200	COG2814	Major facilitator Superfamily
L2D31_05205	COG2732	(Barnase) inhibitor
L2D31_05210	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2D31_05215	COG4605	iron ion homeostasis
L2D31_05220	COG4604	ABC transporter, ATP-binding protein
L2D31_05225	COG4607	ABC-type enterochelin transport system periplasmic component
L2D31_05230	COG1316	TRANSCRIPTIONal
L2D31_05245	COG0398	Pfam SNARE associated Golgi protein
L2D31_05250	COG0681	Belongs to the peptidase S26 family
L2D31_05255	COG3180	Ammonia monooxygenase
L2D31_05270	COG2259	Doxx family
L2D31_05275	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
L2D31_05280	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
L2D31_05285	COG1074	ATP-dependent DNA helicase activity
L2D31_05290	COG0420	3'-5' exonuclease activity
L2D31_05295	COG0419	ATPase involved in DNA repair
L2D31_05300	COG1403	HNH endonuclease
L2D31_05340	COG5337	Spore coat protein CotH
L2D31_05345	COG0179	Fumarylacetoacetate (FAA) hydrolase
L2D31_05360	COG0367	asparagine synthase
L2D31_05375	COG1562	ergosterol biosynthetic process
L2D31_05380	COG0534	Mate efflux family protein
L2D31_05385	COG1917	Cupin 2, conserved barrel domain protein
L2D31_05385	COG2207	Transcriptional regulator
L2D31_05410	COG0076	glutamate decarboxylase activity
L2D31_05445	COG0646	methionine synthase
L2D31_05445	COG1410	methionine synthase
L2D31_05450	COG0646	methionine synthase
L2D31_05450	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
L2D31_05455	COG1666	GTP binding
L2D31_05460	COG2996	Protein conserved in bacteria
L2D31_05465	COG1744	ABC transporter substrate-binding protein PnrA-like
L2D31_05470	COG0840	transmembrane signaling receptor activity
L2D31_05475	COG1307	EDD domain protein, DegV family
L2D31_05480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L2D31_05500	COG0561	phosphatase activity
L2D31_05505	COG1073	alpha beta
L2D31_05510	COG2151	metal-sulfur cluster biosynthetic enzyme
L2D31_05515	COG0277	FAD linked oxidase domain protein
L2D31_05520	COG2271	Major facilitator Superfamily
L2D31_05525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
L2D31_05530	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
L2D31_05535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
L2D31_05540	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2D31_05545	COG0505	Belongs to the CarA family
L2D31_05550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L2D31_05555	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
L2D31_05565	COG2814	Major facilitator Superfamily
L2D31_05575	COG2267	carboxylic ester hydrolase activity
L2D31_05585	COG1744	ABC transporter substrate-binding protein PnrA-like
L2D31_05600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L2D31_05605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
L2D31_05610	COG5504	Zn-dependent protease
L2D31_05615	COG0444	Belongs to the ABC transporter superfamily
L2D31_05620	COG4608	Belongs to the ABC transporter superfamily
L2D31_05630	COG0601	transmembrane transport
L2D31_05635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2D31_05645	COG0180	Tryptophanyl-tRNA synthetase
L2D31_05655	COG4166	transmembrane transport
L2D31_05660	COG0601	transmembrane transport
L2D31_05665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2D31_05670	COG0444	Belongs to the ABC transporter superfamily
L2D31_05675	COG4608	Belongs to the ABC transporter superfamily
L2D31_05685	COG0456	acetyltransferase
L2D31_05690	COG1393	Belongs to the ArsC family
L2D31_05695	COG0861	Integral membrane protein TerC family
L2D31_05700	COG4862	establishment of competence for transformation
L2D31_05705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2D31_05710	COG4469	Competence protein
L2D31_05715	COG1164	Oligoendopeptidase f
L2D31_05725	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2D31_05730	COG2346	COG2346, Truncated hemoglobins
L2D31_05735	COG0741	lytic transglycosylase activity
L2D31_05740	COG4116	CYTH
L2D31_05750	COG2357	RelA SpoT domain protein
L2D31_05755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2D31_05760	COG0564	pseudouridine synthase activity
L2D31_05765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
L2D31_05770	COG0475	glutathione-regulated potassium exporter activity
L2D31_05770	COG0569	domain protein
L2D31_05775	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2D31_05780	COG0352	thiamine-phosphate diphosphorylase activity
L2D31_05790	COG2104	thiamine diphosphate biosynthetic process
L2D31_05795	COG2022	thiamine diphosphate biosynthetic process
L2D31_05800	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L2D31_05805	COG0351	phosphomethylpyrimidine kinase
L2D31_05810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
L2D31_05865	COG0210	DNA helicase
L2D31_05875	COG2153	protein acetylation
L2D31_05880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
L2D31_05885	COG2382	esterase
L2D31_05890	COG0626	cystathionine gamma-synthase activity
L2D31_05895	COG0626	cystathionine gamma-synthase activity
L2D31_05920	COG0825	malonyl-CoA metabolic process
L2D31_05940	COG2807	transmembrane transport
L2D31_05950	COG0583	DNA-binding transcription factor activity
L2D31_05970	COG0457	Tetratricopeptide repeat
L2D31_05985	COG0583	DNA-binding transcription factor activity
L2D31_06005	COG0583	DNA-binding transcription factor activity
L2D31_06010	COG2807	transmembrane transport
L2D31_06040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
L2D31_06050	COG1309	transcriptional regulator
L2D31_06065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L2D31_06070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L2D31_06090	COG4195	phage-related replication protein
L2D31_06095	COG2856	Zn peptidase
L2D31_06100	COG3409	Peptidoglycan-binding domain 1 protein
L2D31_06100	COG5632	N-Acetylmuramoyl-L-alanine amidase
L2D31_06115	COG0306	phosphate transporter
L2D31_06120	COG1392	Phosphate transport regulator
L2D31_06130	COG0405	Gamma-glutamyltransferase
L2D31_06135	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
L2D31_06145	COG4208	sulfate ABC transporter
L2D31_06160	COG3775	system Galactitol-specific IIC component
L2D31_06175	COG1063	alcohol dehydrogenase
L2D31_06180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2D31_06185	COG0022	dehydrogenase e1 component
L2D31_06185	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2D31_06190	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2D31_06195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2D31_06200	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_06205	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_06210	COG2390	Transcriptional regulator
L2D31_06220	COG0531	amino acid
L2D31_06225	COG0346	lactoylglutathione lyase activity
L2D31_06230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2D31_06235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L2D31_06240	COG2362	D-Aminopeptidase
L2D31_06245	COG0601	transmembrane transport
L2D31_06250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2D31_06255	COG0444	Belongs to the ABC transporter superfamily
L2D31_06260	COG4166	transmembrane transport
L2D31_06265	COG1619	proteins homologs of microcin C7 resistance protein MccF
L2D31_06270	COG4948	Mandelate Racemase Muconate Lactonizing
L2D31_06275	COG0791	NLP P60 protein
L2D31_06280	COG4608	Belongs to the ABC transporter superfamily
L2D31_06285	COG1834	amidinotransferase
L2D31_06290	COG1607	acyl-coa hydrolase
L2D31_06295	COG1695	Transcriptional regulator
L2D31_06310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2D31_06320	COG2076	Multidrug Resistance protein
L2D31_06325	COG2076	Multidrug Resistance protein
L2D31_06335	COG0788	formyltetrahydrofolate deformylase activity
L2D31_06340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L2D31_06345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L2D31_06350	COG0457	Tetratricopeptide repeat
L2D31_06360	COG1764	response to oxidative stress
L2D31_06365	COG1846	Transcriptional regulator
L2D31_06370	COG1764	response to oxidative stress
L2D31_06375	COG0590	tRNA wobble adenosine to inosine editing
L2D31_06380	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L2D31_06385	COG1404	Belongs to the peptidase S8 family
L2D31_06400	COG0745	RESPONSE REGULATOR receiver
L2D31_06405	COG5002	protein histidine kinase activity
L2D31_06405	COG3850	Histidine kinase
L2D31_06410	COG3212	peptidase
L2D31_06415	COG3212	peptidase
L2D31_06425	COG2239	Acts as a magnesium transporter
L2D31_06435	COG0583	DNA-binding transcription factor activity
L2D31_06445	COG0789	Transcriptional regulator
L2D31_06460	COG1846	Transcriptional regulator
L2D31_06465	COG5001	Diguanylate cyclase
L2D31_06465	COG3300	MHYT domain
L2D31_06470	COG0586	Pfam SNARE associated Golgi protein
L2D31_06475	COG0861	Integral membrane protein TerC family
L2D31_06480	COG1191	sigma factor activity
L2D31_06500	COG0501	Belongs to the peptidase M48B family
L2D31_06505	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
L2D31_06510	COG2323	membrane
L2D31_06525	COG3594	Acyltransferase
L2D31_06530	COG5002	protein histidine kinase activity
L2D31_06535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
L2D31_06540	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
L2D31_06545	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
L2D31_06550	COG0436	Aminotransferase
L2D31_06555	COG1850	ribulose-bisphosphate carboxylase activity
L2D31_06560	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
L2D31_06565	COG0235	Class ii aldolase
L2D31_06570	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
L2D31_06580	COG3852	Histidine kinase
L2D31_06585	COG1846	Transcriptional regulator
L2D31_06590	COG1360	Flagellar Motor Protein
L2D31_06595	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
L2D31_06600	COG0542	response to heat
L2D31_06605	COG3949	Membrane
L2D31_06610	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
L2D31_06615	COG0720	synthase
L2D31_06620	COG0602	queuosine metabolic process
L2D31_06625	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
L2D31_06640	COG4873	Protein conserved in bacteria
L2D31_06650	COG3773	Cell wall hydrolase
L2D31_06655	COG2244	polysaccharide biosynthetic process
L2D31_06660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2D31_06665	COG2217	Heavy metal translocating P-type atpase
L2D31_06670	COG0006	proline dipeptidase activity
L2D31_06675	COG1609	Transcriptional regulator
L2D31_06680	COG3711	transcriptional antiterminator
L2D31_06685	COG1263	PTS System
L2D31_06685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2D31_06685	COG2190	(PTS) system
L2D31_06690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2D31_06695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
L2D31_06705	COG1533	DNA photolyase activity
L2D31_06710	COG0840	transmembrane signaling receptor activity
L2D31_06720	COG2084	Dehydrogenase
L2D31_06725	COG2340	Cysteine-rich secretory protein family
L2D31_06730	COG0768	penicillin binding
L2D31_06735	COG4191	Histidine kinase
L2D31_06740	COG0436	Aminotransferase
L2D31_06745	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
L2D31_06755	COG1714	RDD family
L2D31_06765	COG0784	Response regulator, receiver
L2D31_06765	COG0835	chemotaxis
L2D31_06790	COG2814	Major facilitator Superfamily
L2D31_06795	COG1376	ErfK ybiS ycfS ynhG family protein
L2D31_06800	COG1408	metallophosphoesterase
L2D31_06805	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_06810	COG2200	EAL domain
L2D31_06815	COG3546	catalase activity
L2D31_06820	COG4703	Protein of unknown function (DUF1797)
L2D31_06825	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
L2D31_06835	COG0517	IMP dehydrogenase activity
L2D31_06840	COG0583	DNA-binding transcription factor activity
L2D31_06850	COG0716	FMN binding
L2D31_06860	COG0716	FMN binding
L2D31_06865	COG2171	N-acyltransferase activity
L2D31_06870	COG1473	amidohydrolase
L2D31_06880	COG0668	transmembrane transport
L2D31_06885	COG0450	alkyl hydroperoxide reductase
L2D31_06890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2D31_06905	COG0746	molybdenum cofactor guanylyltransferase activity
L2D31_06910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
L2D31_06915	COG0303	'Molybdopterin
L2D31_06920	COG1763	Mo-molybdopterin cofactor biosynthetic process
L2D31_06925	COG0314	molybdopterin synthase activity
L2D31_06930	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
L2D31_06945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
L2D31_06950	COG1136	(ABC) transporter
L2D31_06955	COG0577	efflux transmembrane transporter activity
L2D31_06960	COG1349	DNA-binding transcription factor activity
L2D31_06965	COG1105	Belongs to the carbohydrate kinase PfkB family
L2D31_06970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2D31_06970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2D31_06970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2D31_06975	COG0681	Belongs to the peptidase S26 family
L2D31_06985	COG0488	(ABC) transporter
L2D31_06990	COG2309	aminopeptidase activity
L2D31_07000	COG1077	Cell shape determining protein MreB Mrl
L2D31_07005	COG2002	toxin-antitoxin pair type II binding
L2D31_07010	COG3852	Histidine kinase
L2D31_07015	COG2105	PFAM AIG2 family protein
L2D31_07015	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
L2D31_07020	COG0569	domain protein
L2D31_07025	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
L2D31_07030	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L2D31_07035	COG5503	Protein of unknown function (DUF1447)
L2D31_07040	COG0561	phosphatase activity
L2D31_07045	COG0242	peptide deformylase activity
L2D31_07060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2D31_07065	COG0022	dehydrogenase e1 component
L2D31_07070	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2D31_07075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2D31_07080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2D31_07090	COG1982	Orn Lys Arg decarboxylase major
L2D31_07095	COG4476	Belongs to the UPF0223 family
L2D31_07100	COG4493	Belongs to the UPF0637 family
L2D31_07110	COG0483	inositol monophosphate 1-phosphatase activity
L2D31_07125	COG1595	DNA-templated transcription, initiation
L2D31_07145	COG1217	gtp-binding protein TYPA
L2D31_07155	COG4896	Protein conserved in bacteria
L2D31_07165	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
L2D31_07170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
L2D31_07175	COG2066	Belongs to the glutaminase family
L2D31_07180	COG4838	Belongs to the UPF0358 family
L2D31_07185	COG0772	Belongs to the SEDS family
L2D31_07190	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
L2D31_07195	COG0415	Belongs to the DNA photolyase family
L2D31_07200	COG1612	heme a metabolic process
L2D31_07205	COG0109	protoheme IX farnesyltransferase activity
L2D31_07210	COG2010	Cytochrome c
L2D31_07210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2D31_07215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2D31_07220	COG1845	cytochrome c oxidase, subunit III
L2D31_07225	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2D31_07230	COG3336	cytochrome c oxidase
L2D31_07240	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
L2D31_07245	COG2340	Cysteine-rich secretory protein family
L2D31_07265	COG3679	Belongs to the UPF0342 family
L2D31_07270	COG4471	UPF0298 protein
L2D31_07275	COG0742	ribosomal rna small subunit methyltransferase
L2D31_07280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
L2D31_07285	COG3314	Sporulation integral membrane protein YlbJ
L2D31_07290	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2D31_07295	COG3480	Lon protease (S16) C-terminal proteolytic domain
L2D31_07305	COG1399	metal-binding, possibly nucleic acid-binding protein
L2D31_07310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
L2D31_07320	COG0454	-acetyltransferase
L2D31_07325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
L2D31_07330	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
L2D31_07335	COG2001	Belongs to the MraZ family
L2D31_07340	COG0275	rRNA processing
L2D31_07345	COG4839	cell division protein FtsL
L2D31_07350	COG0768	penicillin binding
L2D31_07355	COG0768	penicillin binding
L2D31_07360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
L2D31_07365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2D31_07370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L2D31_07375	COG0772	Belongs to the SEDS family
L2D31_07380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L2D31_07385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
L2D31_07390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
L2D31_07395	COG3879	Bacterial protein of unknown function (DUF881)
L2D31_07400	COG3879	Bacterial protein of unknown function (DUF881)
L2D31_07405	COG3856	small basic protein
L2D31_07410	COG0849	cell division
L2D31_07415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
L2D31_07420	COG1404	Belongs to the peptidase S8 family
L2D31_07420	COG4412	M6 family metalloprotease domain protein
L2D31_07430	COG1191	sigma factor activity
L2D31_07435	COG1191	sigma factor activity
L2D31_07440	COG2390	Transcriptional regulator
L2D31_07455	COG3730	PTS system glucitol sorbitol-specific
L2D31_07460	COG3732	PTS system glucitol sorbitol-specific
L2D31_07470	COG1119	ATPase activity
L2D31_07475	COG1873	PFAM PRC-barrel domain
L2D31_07480	COG1496	oxidoreductase activity
L2D31_07485	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
L2D31_07490	COG1799	cell septum assembly
L2D31_07495	COG0762	integral membrane protein
L2D31_07500	COG2302	S4 RNA-binding domain
L2D31_07505	COG3599	regulation of cell shape
L2D31_07510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
L2D31_07515	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2D31_07520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
L2D31_07525	COG0564	pseudouridine synthase activity
L2D31_07530	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
L2D31_07535	COG2233	PERMEase
L2D31_07540	COG0540	Belongs to the ATCase OTCase family
L2D31_07545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
L2D31_07550	COG0505	Belongs to the CarA family
L2D31_07555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
L2D31_07560	COG0543	2 iron, 2 sulfur cluster binding
L2D31_07565	COG0167	dihydroorotate dehydrogenase activity
L2D31_07570	COG0284	orotidine-5'-phosphate decarboxylase activity
L2D31_07575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
L2D31_07585	COG0175	sulfate reduction
L2D31_07590	COG0306	phosphate transporter
L2D31_07595	COG2046	Belongs to the sulfate adenylyltransferase family
L2D31_07600	COG0529	Catalyzes the synthesis of activated sulfate
L2D31_07605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
L2D31_07610	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
L2D31_07615	COG1648	precorrin-2 dehydrogenase activity
L2D31_07625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
L2D31_07630	COG1561	YicC-like family, N-terminal region
L2D31_07635	COG2052	Domain of unknown function (DUF370)
L2D31_07640	COG0194	GDP metabolic process
L2D31_07645	COG1758	RNA polymerase activity
L2D31_07650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2D31_07655	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
L2D31_07660	COG0242	peptide deformylase activity
L2D31_07665	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
L2D31_07670	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
L2D31_07670	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L2D31_07675	COG0820	rRNA (adenine-C2-)-methyltransferase activity
L2D31_07680	COG0631	protein serine/threonine phosphatase activity
L2D31_07685	COG0515	serine threonine protein kinase
L2D31_07685	COG2815	serine threonine protein kinase
L2D31_07690	COG1162	GTPase activity
L2D31_07695	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2D31_07700	COG1564	THIamine pyrophosphokinase
L2D31_07710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
L2D31_07715	COG1302	Protein conserved in bacteria
L2D31_07720	COG1461	Dihydroxyacetone kinase
L2D31_07725	COG1760	l-serine dehydratase
L2D31_07730	COG1760	l-serine dehydratase
L2D31_07735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
L2D31_07740	COG1349	DNA-binding transcription factor activity
L2D31_07745	COG0416	fatty acid biosynthetic process
L2D31_07750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
L2D31_07755	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_07760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2D31_07770	COG1196	nuclear chromosome segregation
L2D31_07775	COG0552	protein localization to endoplasmic reticulum
L2D31_07780	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
L2D31_07785	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
L2D31_07790	COG0228	four-way junction DNA binding
L2D31_07795	COG1837	Belongs to the UPF0109 family
L2D31_07805	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
L2D31_07810	COG0336	Belongs to the RNA methyltransferase TrmD family
L2D31_07815	COG0335	large ribosomal subunit rRNA binding
L2D31_07820	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L2D31_07825	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2D31_07835	COG2257	FlhB HrpN YscU SpaS Family
L2D31_07840	COG0045	succinate-CoA ligase (ADP-forming) activity
L2D31_07845	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
L2D31_07850	COG0758	DNA mediated transformation
L2D31_07855	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
L2D31_07860	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
L2D31_07865	COG4974	Belongs to the 'phage' integrase family
L2D31_07870	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
L2D31_07875	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
L2D31_07880	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2D31_07885	COG1815	bacterial-type flagellum-dependent cell motility
L2D31_07890	COG1558	bacterial-type flagellum-dependent cell motility
L2D31_07895	COG1677	Flagellar hook-basal body complex protein FliE
L2D31_07900	COG1766	The M ring may be actively involved in energy transduction
L2D31_07905	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L2D31_07910	COG1317	bacterial-type flagellum organization
L2D31_07915	COG1157	protein secretion by the type III secretion system
L2D31_07920	COG2882	bacterial-type flagellum organization
L2D31_07925	COG3334	PFAM MgtE intracellular
L2D31_07930	COG3144	bacterial-type flagellum assembly
L2D31_07935	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
L2D31_07940	COG4786	Flagellar basal body rod
L2D31_07945	COG1582	Flagellar protein (FlbD)
L2D31_07950	COG1580	Controls the rotational direction of flagella during chemotaxis
L2D31_07955	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L2D31_07960	COG1776	CheC inhibitor of MCP methylation
L2D31_07960	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
L2D31_07965	COG2201	protein-glutamate methylesterase activity
L2D31_07970	COG3190	flagellar
L2D31_07975	COG1338	Plays a role in the flagellum-specific transport system
L2D31_07980	COG1987	bacterial-type flagellum assembly
L2D31_07985	COG1684	flagellar biosynthetic protein fliR
L2D31_07990	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L2D31_07995	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
L2D31_08000	COG1419	protein localization to endoplasmic reticulum
L2D31_08005	COG0455	bacterial-type flagellum organization
L2D31_08010	COG2201	protein-glutamate methylesterase activity
L2D31_08015	COG0643	Histidine kinase
L2D31_08015	COG2198	Histidine kinase
L2D31_08020	COG0835	chemotaxis
L2D31_08025	COG1776	CheC inhibitor of MCP methylation
L2D31_08035	COG1191	sigma factor activity
L2D31_08050	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
L2D31_08055	COG0528	UMP kinase activity
L2D31_08060	COG0233	cytoplasmic translational termination
L2D31_08065	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
L2D31_08070	COG4589	Belongs to the CDS family
L2D31_08075	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
L2D31_08080	COG0750	zinc metalloprotease
L2D31_08085	COG0442	prolyl-tRNA aminoacylation
L2D31_08090	COG2176	DNA-directed DNA polymerase activity
L2D31_08105	COG3693	PFAM glycoside hydrolase, family 10
L2D31_08115	COG0779	Required for maturation of 30S ribosomal subunits
L2D31_08120	COG0195	Participates in both transcription termination and antitermination
L2D31_08125	COG2740	Nucleic-acid-binding protein implicated in transcription termination
L2D31_08130	COG1358	cellular component organization or biogenesis
L2D31_08135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
L2D31_08140	COG1550	Protein conserved in bacteria
L2D31_08145	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
L2D31_08150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
L2D31_08155	COG0196	riboflavin kinase activity
L2D31_08160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
L2D31_08165	COG1185	polyribonucleotide nucleotidyltransferase activity
L2D31_08175	COG0612	Peptidase, M16
L2D31_08180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2D31_08190	COG1132	(ABC) transporter
L2D31_08195	COG1132	(ABC) transporter
L2D31_08230	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
L2D31_08250	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_08255	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_08260	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L2D31_08265	COG1260	myo-inositol-1-phosphate synthase
L2D31_08310	COG0367	asparagine synthase
L2D31_08315	COG1873	PFAM PRC-barrel domain
L2D31_08320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L2D31_08325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
L2D31_08330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
L2D31_08335	COG0527	aspartate kinase activity
L2D31_08345	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
L2D31_08350	COG0740	serine-type endopeptidase activity
L2D31_08360	COG1674	ftsk spoiiie
L2D31_08360	COG4980	gas vesicle protein
L2D31_08365	COG2188	Transcriptional regulator
L2D31_08370	COG2814	Major facilitator Superfamily
L2D31_08375	COG1033	growth of symbiont in host cell
L2D31_08375	COG2409	Drug exporters of the RND superfamily
L2D31_08380	COG0612	Peptidase, M16
L2D31_08385	COG0612	Peptidase, M16
L2D31_08395	COG1033	growth of symbiont in host cell
L2D31_08395	COG2409	Drug exporters of the RND superfamily
L2D31_08400	COG0300	oxidoreductase activity
L2D31_08415	COG1426	Protein conserved in bacteria
L2D31_08420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
L2D31_08425	COG1546	Belongs to the CinA family
L2D31_08425	COG1058	Belongs to the CinA family
L2D31_08430	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
L2D31_08435	COG1418	mRNA catabolic process
L2D31_08440	COG1692	metallophosphoesterase
L2D31_08445	COG2359	stage V sporulation protein S
L2D31_08450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
L2D31_08455	COG1063	alcohol dehydrogenase
L2D31_08460	COG0156	8-amino-7-oxononanoate synthase activity
L2D31_08465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L2D31_08470	COG4550	Control of competence regulator ComK, YlbF/YmcA
L2D31_08485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
L2D31_08505	COG1329	Transcriptional regulator
L2D31_08510	COG4195	phage-related replication protein
L2D31_08515	COG0457	Tetratricopeptide repeat
L2D31_08520	COG1404	Belongs to the peptidase S8 family
L2D31_08525	COG4195	phage-related replication protein
L2D31_08530	COG1764	response to oxidative stress
L2D31_08535	COG2076	Multidrug Resistance protein
L2D31_08560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
L2D31_08565	COG1923	regulation of RNA biosynthetic process
L2D31_08580	COG1780	Probably involved in ribonucleotide reductase function
L2D31_08585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2D31_08590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
L2D31_08595	COG4112	unkown
L2D31_08605	COG0464	growth
L2D31_08610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
L2D31_08615	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
L2D31_08620	COG0789	Transcriptional regulator
L2D31_08625	COG0174	glutamine synthetase
L2D31_08645	COG0457	Tetratricopeptide repeat
L2D31_08655	COG0604	alcohol dehydrogenase
L2D31_08665	COG5444	nuclease activity
L2D31_08685	COG5646	InterPro IPR014922
L2D31_08705	COG0457	Tetratricopeptide repeat
L2D31_08715	COG3619	membrane
L2D31_08720	COG3285	dna ligase
L2D31_08720	COG1793	dna ligase
L2D31_08725	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
L2D31_08730	COG4876	unkown
L2D31_08740	COG1959	2 iron, 2 sulfur cluster binding
L2D31_08745	COG0702	epimerase
L2D31_08755	COG0247	lactate metabolic process
L2D31_08760	COG1139	Iron-sulfur cluster binding protein
L2D31_08765	COG1556	Lactate utilization protein
L2D31_08780	COG2323	membrane
L2D31_08785	COG1309	transcriptional regulator
L2D31_08790	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2D31_08790	COG2124	cytochrome p450
L2D31_08795	COG3591	Belongs to the peptidase S1B family
L2D31_08800	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L2D31_08805	COG3209	COG3209 Rhs family protein
L2D31_08810	COG1366	Belongs to the anti-sigma-factor antagonist family
L2D31_08825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
L2D31_08830	COG1388	LysM domain
L2D31_08835	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2D31_08840	COG4224	UPF0291 protein
L2D31_08845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
L2D31_08855	COG3763	UPF0154 protein
L2D31_08865	COG0785	Cytochrome C biogenesis protein
L2D31_08870	COG4846	Membrane protein involved in cytochrome C biogenesis
L2D31_08880	COG0071	Belongs to the small heat shock protein (HSP20) family
L2D31_08895	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
L2D31_08900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2D31_08920	COG0824	Thioesterase
L2D31_08930	COG4841	protein insertion into membrane
L2D31_08935	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
L2D31_08940	COG1832	CoA-binding protein
L2D31_08945	COG0187	DNA topoisomerase II activity
L2D31_08950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
L2D31_08960	COG0738	Major facilitator superfamily
L2D31_08965	COG0473	3-isopropylmalate dehydrogenase activity
L2D31_08970	COG0110	maltose O-acetyltransferase activity
L2D31_08975	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2D31_08980	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
L2D31_08985	COG0640	Transcriptional regulator
L2D31_08995	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2D31_09000	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2D31_09010	COG1309	transcriptional regulator
L2D31_09015	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2D31_09020	COG1733	regulation of RNA biosynthetic process
L2D31_09030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2D31_09035	COG0251	oxidation-reduction process
L2D31_09075	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
L2D31_09100	COG0657	acetylesterase activity
L2D31_09110	COG2723	6-phospho-beta-galactosidase activity
L2D31_09115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2D31_09115	COG2190	(PTS) system
L2D31_09115	COG1263	PTS System
L2D31_09130	COG2205	protein histidine kinase activity
L2D31_09135	COG0745	RESPONSE REGULATOR receiver
L2D31_09145	COG3507	Belongs to the glycosyl hydrolase 43 family
L2D31_09150	COG1012	belongs to the aldehyde dehydrogenase family
L2D31_09155	COG1486	melibiose metabolic process
L2D31_09160	COG0395	ABC-type sugar transport system, permease component
L2D31_09165	COG1175	transmembrane transport
L2D31_09170	COG1653	transport
L2D31_09175	COG1609	Transcriptional regulator
L2D31_09180	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
L2D31_09195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2D31_09205	COG0456	acetyltransferase
L2D31_09210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2D31_09220	COG1846	Transcriptional regulator
L2D31_09225	COG2814	Major facilitator Superfamily
L2D31_09235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2D31_09235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2D31_09235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2D31_09240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2D31_09240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2D31_09240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
L2D31_09245	COG1105	Belongs to the carbohydrate kinase PfkB family
L2D31_09255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2D31_09275	COG1012	belongs to the aldehyde dehydrogenase family
L2D31_09280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
L2D31_09285	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
L2D31_09290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2D31_09295	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2D31_09300	COG1024	Enoyl-CoA hydratase
L2D31_09305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2D31_09310	COG0511	ligase activity, forming carbon-carbon bonds
L2D31_09315	COG0439	Biotin carboxylase
L2D31_09320	COG0318	PFAM AMP-dependent synthetase and ligase
L2D31_09325	COG1960	acyl-CoA dehydrogenase activity
L2D31_09330	COG1649	PFAM Uncharacterised BCR, COG1649
L2D31_09335	COG2365	Tyrosine phosphatase family
L2D31_09340	COG1349	DNA-binding transcription factor activity
L2D31_09345	COG1942	4-Oxalocrotonate Tautomerase
L2D31_09355	COG3835	regulator
L2D31_09360	COG0277	FAD linked oxidase domain protein
L2D31_09365	COG0247	lactate metabolic process
L2D31_09385	COG0166	Belongs to the GPI family
L2D31_09390	COG2246	polysaccharide biosynthetic process
L2D31_09395	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2D31_09400	COG0586	Pfam SNARE associated Golgi protein
L2D31_09405	COG1587	Uroporphyrinogen-III synthase
L2D31_09415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2D31_09430	COG0534	Mate efflux family protein
L2D31_09435	COG2027	D-alanyl-D-alanine carboxypeptidase
L2D31_09440	COG4677	pectinesterase activity
L2D31_09445	COG2323	membrane
L2D31_09450	COG0493	'glutamate synthase
L2D31_09455	COG0067	glutamate synthase
L2D31_09455	COG0069	glutamate synthase activity
L2D31_09455	COG0070	glutamate synthase
L2D31_09460	COG0583	DNA-binding transcription factor activity
L2D31_09470	COG1132	(ABC) transporter
L2D31_09475	COG0789	Transcriptional regulator
L2D31_09475	COG4978	Transcriptional regulator
L2D31_09480	COG0454	-acetyltransferase
L2D31_09485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
L2D31_09490	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
L2D31_09495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L2D31_09505	COG0243	molybdopterin cofactor binding
L2D31_09515	COG1070	Carbohydrate kinase
L2D31_09520	COG2115	Belongs to the xylose isomerase family
L2D31_09525	COG1940	carbohydrate kinase activity
L2D31_09535	COG2211	Major facilitator Superfamily
L2D31_09540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2D31_09545	COG1994	Peptidase M50
L2D31_09565	COG1309	transcriptional regulator
L2D31_09570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2D31_09575	COG3708	Transcriptional regulator
L2D31_09580	COG2378	regulation of single-species biofilm formation
L2D31_09590	COG0640	Transcriptional regulator
L2D31_09595	COG0531	amino acid
L2D31_09600	COG0741	lytic transglycosylase activity
L2D31_09605	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
L2D31_09610	COG2079	MmgE PrpD family protein
L2D31_09615	COG0372	Belongs to the citrate synthase family
L2D31_09620	COG2322	membrane
L2D31_09630	COG1388	LysM domain
L2D31_09630	COG3584	3D domain protein
L2D31_09635	COG0514	ATP-dependent DNA helicase (RecQ)
L2D31_09645	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2D31_09670	COG1012	belongs to the aldehyde dehydrogenase family
L2D31_09675	COG1657	PFAM Prenyltransferase squalene oxidase
L2D31_09680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2D31_09685	COG0385	Bile acid
L2D31_09690	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2D31_09695	COG0567	Dehydrogenase, E1 component
L2D31_09700	COG4548	von Willebrand factor, type A
L2D31_09705	COG0714	Associated with various cellular activities
L2D31_09710	COG2032	superoxide dismutase activity
L2D31_09715	COG0791	NLP P60 protein
L2D31_09715	COG1388	LysM domain
L2D31_09720	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
L2D31_09725	COG0534	Mate efflux family protein
L2D31_09730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L2D31_09735	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L2D31_09745	COG2962	Rard protein
L2D31_09760	COG1733	regulation of RNA biosynthetic process
L2D31_09765	COG0778	Nitroreductase
L2D31_09775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2D31_09780	COG0793	Belongs to the peptidase S41A family
L2D31_09780	COG3409	Peptidoglycan-binding domain 1 protein
L2D31_09785	COG2226	methyltransferase
L2D31_09795	COG1876	peptidase activity
L2D31_09800	COG0813	purine-nucleoside phosphorylase activity
L2D31_09810	COG0671	phosphoesterase, PA-phosphatase related
L2D31_09825	COG4479	Belongs to the UPF0346 family
L2D31_09835	COG1509	lysine 2,3-aminomutase activity
L2D31_09840	COG3829	transcription factor binding
L2D31_09845	COG0463	Glycosyl transferase, family 2
L2D31_09860	COG4641	Protein conserved in bacteria
L2D31_09870	COG1086	Polysaccharide biosynthesis protein
L2D31_09875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L2D31_09880	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
L2D31_09885	COG1846	Transcriptional regulator
L2D31_09905	COG4698	Protein conserved in bacteria
L2D31_09910	COG2755	lipolytic protein G-D-S-L family
L2D31_09915	COG1999	signal sequence binding
L2D31_09930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
L2D31_09935	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
L2D31_09940	COG1272	protein, Hemolysin III
L2D31_09945	COG0204	Acyl-transferase
L2D31_09950	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
L2D31_09955	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
L2D31_09960	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2D31_09970	COG2521	methyltransferase
L2D31_09970	COG2136	Putative SAM-dependent methyltransferase
L2D31_09980	COG0129	dihydroxy-acid dehydratase activity
L2D31_09985	COG1413	lyase activity
L2D31_09990	COG1418	mRNA catabolic process
L2D31_09995	COG0386	Belongs to the glutathione peroxidase family
L2D31_10000	COG2759	Belongs to the formate--tetrahydrofolate ligase family
L2D31_10005	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
L2D31_10010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
L2D31_10020	COG1278	Cold shock
L2D31_10035	COG0328	RNA-DNA hybrid ribonuclease activity
L2D31_10040	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
L2D31_10045	COG0328	RNA-DNA hybrid ribonuclease activity
L2D31_10055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L2D31_10065	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L2D31_10070	COG1755	Isoprenylcysteine carboxyl methyltransferase
L2D31_10075	COG3424	synthase
L2D31_10080	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2D31_10080	COG0456	acetyltransferase
L2D31_10085	COG0726	polysaccharide deacetylase
L2D31_10090	COG2233	PERMEase
L2D31_10095	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L2D31_10100	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
L2D31_10105	COG1199	ATP-dependent helicase activity
L2D31_10115	COG0116	Belongs to the methyltransferase superfamily
L2D31_10125	COG3599	regulation of cell shape
L2D31_10130	COG4474	Belongs to the UPF0398 family
L2D31_10140	COG3359	exonuclease
L2D31_10145	COG1111	helicase
L2D31_10145	COG1205	dead DEAH box helicase
L2D31_10150	COG1902	pentaerythritol trinitrate reductase activity
L2D31_10155	COG2190	(PTS) system
L2D31_10160	COG0071	Belongs to the small heat shock protein (HSP20) family
L2D31_10190	COG3331	DNA recombination
L2D31_10195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2D31_10195	COG4499	WXG100 protein secretion system (Wss), protein YukC
L2D31_10205	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
L2D31_10210	COG3935	DnaD domain protein
L2D31_10215	COG0017	Asparaginyl-tRNA synthetase
L2D31_10220	COG5353	protein conserved in bacteria
L2D31_10230	COG1199	ATP-dependent helicase activity
L2D31_10230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
L2D31_10235	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
L2D31_10240	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
L2D31_10245	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
L2D31_10255	COG0617	tRNA 3'-terminal CCA addition
L2D31_10260	COG0438	transferase activity, transferring glycosyl groups
L2D31_10265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
L2D31_10270	COG1803	Methylglyoxal synthase
L2D31_10275	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
L2D31_10280	COG1694	Mazg nucleotide pyrophosphohydrolase
L2D31_10285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L2D31_10295	COG4347	Protein of unknown function (DUF1405)
L2D31_10300	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L2D31_10300	COG2010	Cytochrome c
L2D31_10305	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
L2D31_10310	COG0723	plastoquinol--plastocyanin reductase activity
L2D31_10320	COG5582	Belongs to the UPF0302 family
L2D31_10325	COG0457	Tetratricopeptide repeat
L2D31_10330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
L2D31_10335	COG0287	Prephenate dehydrogenase
L2D31_10340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
L2D31_10345	COG0159	tryptophan synthase activity
L2D31_10350	COG0133	tryptophan synthase activity
L2D31_10360	COG0134	indole-3-glycerol-phosphate synthase activity
L2D31_10365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
L2D31_10375	COG4401	Chorismate mutase type I
L2D31_10380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
L2D31_10385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
L2D31_10390	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
L2D31_10395	COG0105	UTP biosynthetic process
L2D31_10400	COG0142	geranyltranstransferase activity
L2D31_10405	COG2226	methyltransferase
L2D31_10410	COG0142	geranyltranstransferase activity
L2D31_10420	COG0302	gtp cyclohydrolase
L2D31_10425	COG0776	regulation of translation
L2D31_10430	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
L2D31_10445	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
L2D31_10450	COG1160	GTP binding
L2D31_10475	COG1304	FMN binding
L2D31_10480	COG0539	negative regulation of cytoplasmic translation
L2D31_10485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
L2D31_10495	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
L2D31_10500	COG2959	enzyme of heme biosynthesis
L2D31_10505	COG3409	Peptidoglycan-binding domain 1 protein
L2D31_10505	COG3773	Cell wall hydrolase
L2D31_10510	COG2339	peptidase activity
L2D31_10515	COG0492	ferredoxin-NADP+ reductase activity
L2D31_10520	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2D31_10525	COG4862	establishment of competence for transformation
L2D31_10530	COG1408	metallophosphoesterase
L2D31_10540	COG1388	LysM domain
L2D31_10545	COG1266	CAAX protease self-immunity
L2D31_10550	COG0514	ATP-dependent DNA helicase (RecQ)
L2D31_10555	COG4955	Helix-turn-helix domain
L2D31_10560	COG1141	Ferredoxin
L2D31_10565	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
L2D31_10570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
L2D31_10585	COG1595	DNA-templated transcription, initiation
L2D31_10590	COG5002	protein histidine kinase activity
L2D31_10595	COG0745	RESPONSE REGULATOR receiver
L2D31_10600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L2D31_10605	COG1333	cytochrome c biogenesis protein
L2D31_10610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2D31_10615	COG1187	pseudouridine synthase activity
L2D31_10620	COG0700	Nucleoside recognition
L2D31_10625	COG2715	membrane protein required for spore maturation
L2D31_10630	COG1686	Belongs to the peptidase S11 family
L2D31_10640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
L2D31_10645	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
L2D31_10655	COG1547	Domain of unknown function (DUF309)
L2D31_10660	COG0456	acetyltransferase
L2D31_10665	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
L2D31_10675	COG0307	riboflavin synthase, alpha
L2D31_10695	COG2814	Major facilitator Superfamily
L2D31_10700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
L2D31_10705	COG4086	secreted protein
L2D31_10710	COG0019	diaminopimelate decarboxylase activity
L2D31_10715	COG0697	spore germination
L2D31_10730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
L2D31_10750	COG1191	sigma factor activity
L2D31_10755	COG2172	sigma factor antagonist activity
L2D31_10765	COG1686	Belongs to the peptidase S11 family
L2D31_10770	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
L2D31_10775	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
L2D31_10780	COG4974	Belongs to the 'phage' integrase family
L2D31_10790	COG0735	belongs to the Fur family
L2D31_10795	COG1300	Membrane
L2D31_10800	COG1404	Belongs to the peptidase S8 family
L2D31_10810	COG2153	protein acetylation
L2D31_10815	COG1379	DNA repair
L2D31_10820	COG0494	nUDIX hydrolase
L2D31_10825	COG0667	Aldo Keto reductase
L2D31_10840	COG1073	alpha beta
L2D31_10845	COG0457	Tetratricopeptide repeat
L2D31_10855	COG4918	Iron-sulphur cluster biosynthesis
L2D31_10860	COG4305	rare lipoprotein A
L2D31_10865	COG0456	acetyltransferase
L2D31_10865	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
L2D31_10870	COG0456	acetyltransferase
L2D31_10880	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2D31_10890	COG2211	Major facilitator Superfamily
L2D31_10895	COG1072	(Pantothenic acid kinase))
L2D31_10900	COG0446	pyridine nucleotide-disulphide oxidoreductase
L2D31_10910	COG0300	oxidoreductase activity
L2D31_10915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2D31_10920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L2D31_10930	COG4187	Peptidase family M20/M25/M40
L2D31_10935	COG1902	pentaerythritol trinitrate reductase activity
L2D31_10940	COG0596	Alpha beta hydrolase
L2D31_10945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
L2D31_10955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
L2D31_10960	COG2188	Transcriptional regulator
L2D31_10965	COG2723	6-phospho-beta-galactosidase activity
L2D31_10970	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L2D31_10975	COG1447	Phosphotransferase system cellobiose-specific component IIA
L2D31_10980	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L2D31_10990	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_11000	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
L2D31_11005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
L2D31_11020	COG0706	membrane insertase activity
L2D31_11025	COG0835	chemotaxis
L2D31_11030	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2D31_11035	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
L2D31_11040	COG0346	lactoylglutathione lyase activity
L2D31_11050	COG1376	ErfK ybiS ycfS ynhG family protein
L2D31_11055	COG4129	membrane
L2D31_11060	COG1126	abc transporter atp-binding protein
L2D31_11065	COG0765	amino acid transport
L2D31_11070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2D31_11080	COG1597	lipid kinase activity
L2D31_11090	COG0508	dehydrogenase complex catalyzes the overall conversion of
L2D31_11095	COG0022	dehydrogenase e1 component
L2D31_11100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
L2D31_11105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
L2D31_11110	COG3426	butyrate kinase activity
L2D31_11115	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2D31_11120	COG0280	phosphate acetyltransferase
L2D31_11125	COG3829	transcription factor binding
L2D31_11125	COG3290	protein histidine kinase activity
L2D31_11135	COG0584	glycerophosphoryl diester phosphodiesterase
L2D31_11140	COG0457	Tetratricopeptide repeat
L2D31_11145	COG0745	RESPONSE REGULATOR receiver
L2D31_11150	COG0750	zinc metalloprotease
L2D31_11155	COG0497	DNA recombination
L2D31_11160	COG1438	arginine binding
L2D31_11165	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
L2D31_11170	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
L2D31_11175	COG0142	geranyltranstransferase activity
L2D31_11180	COG1722	exodeoxyribonuclease VII activity
L2D31_11185	COG1570	exodeoxyribonuclease VII activity
L2D31_11190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
L2D31_11195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
L2D31_11200	COG1302	Protein conserved in bacteria
L2D31_11205	COG0439	Biotin carboxylase
L2D31_11210	COG0511	ligase activity, forming carbon-carbon bonds
L2D31_11250	COG3854	ATPases associated with a variety of cellular activities
L2D31_11260	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
L2D31_11265	COG0006	proline dipeptidase activity
L2D31_11270	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
L2D31_11280	COG3872	metal-dependent enzyme
L2D31_11290	COG1752	Esterase of the alpha-beta hydrolase superfamily
L2D31_11295	COG1321	iron dependent repressor
L2D31_11300	COG0095	Lipoate-protein ligase
L2D31_11305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L2D31_11310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L2D31_11315	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
L2D31_11320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
L2D31_11325	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L2D31_11350	COG0681	Belongs to the peptidase S26 family
L2D31_11385	COG4970	Tfp pilus assembly protein FimT
L2D31_11390	COG4537	Required for transformation and DNA binding
L2D31_11395	COG1459	type II secretion system
L2D31_11400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
L2D31_11405	COG1366	Belongs to the anti-sigma-factor antagonist family
L2D31_11415	COG1393	Belongs to the ArsC family
L2D31_11425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2D31_11435	COG0011	TIGRFAM Protein of
L2D31_11440	COG2814	Major facilitator Superfamily
L2D31_11445	COG2866	Carboxypeptidase
L2D31_11450	COG1368	sulfuric ester hydrolase activity
L2D31_11455	COG1940	carbohydrate kinase activity
L2D31_11460	COG4483	Protein conserved in bacteria
L2D31_11465	COG0457	Tetratricopeptide repeat
L2D31_11465	COG0705	Rhomboid family
L2D31_11480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
L2D31_11485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L2D31_11495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2D31_11500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2D31_11505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
L2D31_11510	COG0581	inorganic phosphate transmembrane transporter activity
L2D31_11515	COG0573	inorganic phosphate transmembrane transporter activity
L2D31_11520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
L2D31_11525	COG0768	penicillin binding
L2D31_11530	COG0477	Major facilitator Superfamily
L2D31_11535	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
L2D31_11540	COG2839	Protein conserved in bacteria
L2D31_11545	COG5521	maltodextrose utilization protein MalA
L2D31_11550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
L2D31_11555	COG1388	LysM domain
L2D31_11560	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
L2D31_11565	COG4709	membrane
L2D31_11570	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
L2D31_11575	COG1940	carbohydrate kinase activity
L2D31_11580	COG0735	belongs to the Fur family
L2D31_11585	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2D31_11590	COG1121	(ABC) transporter
L2D31_11595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L2D31_11610	COG0513	Belongs to the DEAD box helicase family
L2D31_11620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
L2D31_11625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
L2D31_11630	COG2384	SAM-dependent methyltransferase
L2D31_11635	COG2010	Cytochrome c
L2D31_11640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
L2D31_11645	COG0358	DNA primase activity
L2D31_11650	COG1671	Belongs to the UPF0178 family
L2D31_11655	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
L2D31_11660	COG0517	IMP dehydrogenase activity
L2D31_11665	COG0751	glycine-tRNA ligase activity
L2D31_11670	COG0752	glycyl-tRNA synthetase alpha subunit
L2D31_11675	COG1381	Involved in DNA repair and RecF pathway recombination
L2D31_11685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
L2D31_11690	COG0295	cytidine deaminase activity
L2D31_11695	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
L2D31_11700	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
L2D31_11705	COG1480	7TM receptor with intracellular HD hydrolase
L2D31_11710	COG1702	phosphate starvation-inducible protein PhoH
L2D31_11715	COG0561	phosphatase activity
L2D31_11730	COG4864	UPF0365 protein
L2D31_11735	COG1030	water channel activity
L2D31_11740	COG1610	YqeY-like protein
L2D31_11750	COG1283	sodium-dependent phosphate transmembrane transporter activity
L2D31_11755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
L2D31_11760	COG1385	rRNA (uridine-N3-)-methyltransferase activity
L2D31_11765	COG2264	protein methyltransferase activity
L2D31_11770	COG0484	heat shock protein binding
L2D31_11775	COG0443	Heat shock 70 kDa protein
L2D31_11780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
L2D31_11785	COG1420	regulation of RNA biosynthetic process
L2D31_11790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
L2D31_11795	COG0481	GTPase activity
L2D31_11805	COG0860	N-Acetylmuramoyl-L-alanine amidase
L2D31_11810	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
L2D31_11815	COG0268	Binds directly to 16S ribosomal RNA
L2D31_11820	COG1466	dna polymerase III delta subunit
L2D31_11830	COG0658	competence protein
L2D31_11830	COG2333	competence protein COMEC
L2D31_11835	COG2131	deaminase
L2D31_11840	COG1596	polysaccharide export
L2D31_11840	COG1555	photosystem II stabilization
L2D31_11845	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
L2D31_11850	COG2226	methyltransferase
L2D31_11855	COG0799	negative regulation of ribosome biogenesis
L2D31_11860	COG1713	HD superfamily hydrolase involved in NAD metabolism
L2D31_11865	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
L2D31_11870	COG1534	Rna-binding protein
L2D31_11875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L2D31_11880	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
L2D31_11885	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
L2D31_11900	COG2755	lipolytic protein G-D-S-L family
L2D31_11910	COG0457	Tetratricopeptide repeat
L2D31_11920	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
L2D31_11990	COG0726	polysaccharide deacetylase
L2D31_12025	COG2160	L-arabinose isomerase activity
L2D31_12040	COG1609	Transcriptional regulator
L2D31_12050	COG1846	Transcriptional regulator
L2D31_12060	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
L2D31_12065	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
L2D31_12070	COG1733	regulation of RNA biosynthetic process
L2D31_12075	COG0657	acetylesterase activity
L2D31_12095	COG3209	COG3209 Rhs family protein
L2D31_12100	COG2602	Beta-lactamase
L2D31_12105	COG1960	acyl-CoA dehydrogenase activity
L2D31_12110	COG1126	abc transporter atp-binding protein
L2D31_12115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2D31_12120	COG0765	amino acid transport
L2D31_12130	COG1063	alcohol dehydrogenase
L2D31_12140	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_12150	COG1115	amino acid carrier protein
L2D31_12155	COG0583	DNA-binding transcription factor activity
L2D31_12160	COG1063	alcohol dehydrogenase
L2D31_12165	COG2226	methyltransferase
L2D31_12190	COG0626	cystathionine gamma-synthase activity
L2D31_12195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2D31_12200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
L2D31_12205	COG2226	methyltransferase
L2D31_12220	COG0768	penicillin binding
L2D31_12225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
L2D31_12230	COG0572	uridine kinase
L2D31_12235	COG0826	peptidase U32
L2D31_12240	COG0826	peptidase U32
L2D31_12245	COG4122	O-methyltransferase activity
L2D31_12250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
L2D31_12255	COG0183	Belongs to the thiolase family
L2D31_12260	COG0318	PFAM AMP-dependent synthetase and ligase
L2D31_12265	COG1268	BioY protein
L2D31_12270	COG3906	Belongs to the UPF0473 family
L2D31_12275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
L2D31_12280	COG4472	Bacterial protein of unknown function (DUF965)
L2D31_12285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
L2D31_12290	COG0628	permease
L2D31_12295	COG1126	abc transporter atp-binding protein
L2D31_12300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2D31_12305	COG0765	amino acid transport
L2D31_12310	COG0765	amino acid transport
L2D31_12325	COG3881	PFAM PRC-barrel domain
L2D31_12330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
L2D31_12335	COG0457	Tetratricopeptide repeat
L2D31_12340	COG0482	sulfurtransferase activity
L2D31_12345	COG1104	cysteine desulfurase activity
L2D31_12350	COG1959	2 iron, 2 sulfur cluster binding
L2D31_12355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
L2D31_12360	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
L2D31_12375	COG0124	histidyl-tRNA synthetase
L2D31_12385	COG0860	N-Acetylmuramoyl-L-alanine amidase
L2D31_12385	COG3103	Sh3 type 3 domain protein
L2D31_12385	COG4991	sh3 domain protein
L2D31_12390	COG1490	D-aminoacyl-tRNA deacylase activity
L2D31_12395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
L2D31_12400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
L2D31_12405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
L2D31_12405	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
L2D31_12410	COG5416	Lipopolysaccharide assembly protein A domain
L2D31_12415	COG0490	domain, Protein
L2D31_12420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2D31_12420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
L2D31_12430	COG2244	polysaccharide biosynthetic process
L2D31_12435	COG2323	membrane
L2D31_12445	COG1862	Preprotein translocase
L2D31_12450	COG0343	queuine tRNA-ribosyltransferase activity
L2D31_12455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
L2D31_12465	COG2255	four-way junction helicase activity
L2D31_12470	COG0632	four-way junction helicase activity
L2D31_12480	COG2112	serine threonine protein kinase
L2D31_12495	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
L2D31_12515	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
L2D31_12520	COG0157	Belongs to the NadC ModD family
L2D31_12525	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
L2D31_12530	COG1104	cysteine desulfurase activity
L2D31_12535	COG1827	regulation of RNA biosynthetic process
L2D31_12540	COG0077	Prephenate dehydratase
L2D31_12545	COG4492	Belongs to the UPF0735 family
L2D31_12550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
L2D31_12555	COG3290	protein histidine kinase activity
L2D31_12560	COG0211	Belongs to the bacterial ribosomal protein bL27 family
L2D31_12565	COG2868	ribosomal protein
L2D31_12570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
L2D31_12575	COG1994	Peptidase M50
L2D31_12580	COG0739	heme binding
L2D31_12585	COG2894	cell division
L2D31_12590	COG0850	regulation of cytokinetic process
L2D31_12595	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
L2D31_12605	COG1077	Cell shape determining protein MreB Mrl
L2D31_12610	COG2003	Belongs to the UPF0758 family
L2D31_12615	COG0424	maF-like protein
L2D31_12630	COG0285	dihydrofolate synthase activity
L2D31_12635	COG0525	valine-tRNA ligase activity
L2D31_12645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2D31_12650	COG1388	LysM domain
L2D31_12655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
L2D31_12660	COG0113	porphobilinogen synthase activity
L2D31_12665	COG1587	Uroporphyrinogen-III synthase
L2D31_12670	COG0181	hydroxymethylbilane synthase activity
L2D31_12675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
L2D31_12680	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
L2D31_12690	COG0218	Necessary for normal cell division and for the maintenance of normal septation
L2D31_12695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
L2D31_12700	COG1067	ATP-dependent peptidase activity
L2D31_12700	COG0470	DNA polymerase III
L2D31_12705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
L2D31_12710	COG0544	peptidyl-prolyl cis-trans isomerase activity
L2D31_12715	COG0457	Tetratricopeptide repeat
L2D31_12715	COG1477	protein flavinylation
L2D31_12720	COG0066	3-isopropylmalate dehydratase activity
L2D31_12725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
L2D31_12730	COG0473	3-isopropylmalate dehydrogenase activity
L2D31_12735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
L2D31_12740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
L2D31_12745	COG0440	acetolactate synthase activity
L2D31_12750	COG0028	Belongs to the TPP enzyme family
L2D31_12755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2D31_12760	COG2706	6-phosphogluconolactonase activity
L2D31_12765	COG3339	Conserved Protein
L2D31_12770	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
L2D31_12775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
L2D31_12780	COG1696	Membrane protein involved in D-alanine export
L2D31_12785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2D31_12825	COG0622	Phosphoesterase
L2D31_12830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
L2D31_12835	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
L2D31_12840	COG5401	PFAM Sporulation and spore germination
L2D31_12845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
L2D31_12850	COG1846	Transcriptional regulator
L2D31_12855	COG2197	response regulator
L2D31_12860	COG2851	Citrate transporter
L2D31_12865	COG0583	DNA-binding transcription factor activity
L2D31_12870	COG2828	Protein conserved in bacteria
L2D31_12880	COG0824	Thioesterase
L2D31_12885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
L2D31_12890	COG1053	succinate dehydrogenase
L2D31_12895	COG2009	succinate dehydrogenase
L2D31_12900	COG1719	4-vinyl reductase, 4VR
L2D31_12905	COG0527	aspartate kinase activity
L2D31_12910	COG0322	excinuclease ABC activity
L2D31_12915	COG3118	belongs to the thioredoxin family
L2D31_12920	COG3534	alpha-L-arabinofuranosidase
L2D31_12925	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
L2D31_12930	COG2086	electron transfer activity
L2D31_12935	COG1024	Enoyl-CoA hydratase
L2D31_12940	COG1309	transcriptional regulator
L2D31_12945	COG0318	PFAM AMP-dependent synthetase and ligase
L2D31_12955	COG3766	membrane
L2D31_12960	COG1193	negative regulation of DNA recombination
L2D31_12965	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L2D31_12965	COG1796	DNA polymerase
L2D31_12970	COG1286	toxin biosynthetic process
L2D31_12975	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
L2D31_12980	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
L2D31_12985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2D31_12985	COG0072	phenylalanine-tRNA ligase activity
L2D31_12990	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
L2D31_12995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
L2D31_13005	COG1966	Carbon starvation protein
L2D31_13010	COG1363	Peptidase, m42
L2D31_13020	COG3326	Membrane
L2D31_13025	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
L2D31_13030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
L2D31_13035	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
L2D31_13040	COG1346	cytolysis
L2D31_13050	COG3279	Response regulator of the LytR AlgR family
L2D31_13055	COG3275	phosphorelay sensor kinase activity
L2D31_13060	COG1011	Hydrolase
L2D31_13070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
L2D31_13080	COG0398	Pfam SNARE associated Golgi protein
L2D31_13085	COG1484	DNA-dependent DNA replication
L2D31_13090	COG3611	Membrane attachment protein
L2D31_13095	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
L2D31_13105	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
L2D31_13110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2D31_13115	COG0237	dephospho-CoA kinase activity
L2D31_13120	COG1971	Probably functions as a manganese efflux pump
L2D31_13125	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
L2D31_13130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L2D31_13130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
L2D31_13135	COG5002	protein histidine kinase activity
L2D31_13140	COG0745	RESPONSE REGULATOR receiver
L2D31_13145	COG0039	L-malate dehydrogenase activity
L2D31_13150	COG0538	isocitrate dehydrogenase activity
L2D31_13155	COG0372	Belongs to the citrate synthase family
L2D31_13160	COG2707	UPF0756 membrane protein
L2D31_13165	COG0628	permease
L2D31_13170	COG3030	protein affecting phage T7 exclusion by the F plasmid
L2D31_13180	COG0205	6-phosphofructokinase activity
L2D31_13185	COG0825	malonyl-CoA metabolic process
L2D31_13190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
L2D31_13195	COG0281	malic enzyme
L2D31_13200	COG0587	DNA-directed DNA polymerase activity
L2D31_13220	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
L2D31_13230	COG4109	DRTGG domain
L2D31_13235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
L2D31_13240	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_13250	COG0165	Argininosuccinate lyase
L2D31_13255	COG0137	argininosuccinate synthase activity
L2D31_13260	COG0521	Mo-molybdopterin cofactor biosynthetic process
L2D31_13265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
L2D31_13270	COG0827	DNA restriction-modification system
L2D31_13275	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
L2D31_13280	COG3874	Sporulation protein YtfJ
L2D31_13290	COG1714	RDD family
L2D31_13295	COG0616	signal peptide processing
L2D31_13300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
L2D31_13310	COG3239	Fatty acid desaturase
L2D31_13315	COG4585	Histidine kinase
L2D31_13320	COG2197	response regulator
L2D31_13325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L2D31_13330	COG0745	RESPONSE REGULATOR receiver
L2D31_13335	COG2205	protein histidine kinase activity
L2D31_13340	COG0772	Belongs to the SEDS family
L2D31_13345	COG1695	Transcriptional regulator
L2D31_13350	COG1136	(ABC) transporter
L2D31_13355	COG0577	efflux transmembrane transporter activity
L2D31_13360	COG0402	S-adenosylhomocysteine deaminase activity
L2D31_13365	COG2249	NAD(P)H dehydrogenase (quinone) activity
L2D31_13380	COG1279	arginine transmembrane transporter activity
L2D31_13385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2D31_13395	COG0301	tRNA thio-modification
L2D31_13400	COG1104	cysteine desulfurase activity
L2D31_13405	COG1114	Component of the transport system for branched-chain amino acids
L2D31_13410	COG1114	Component of the transport system for branched-chain amino acids
L2D31_13415	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
L2D31_13420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
L2D31_13425	COG1309	transcriptional regulator
L2D31_13430	COG1956	GAF domain-containing protein
L2D31_13435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
L2D31_13450	COG1335	isochorismatase
L2D31_13460	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
L2D31_13470	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
L2D31_13475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
L2D31_13480	COG0454	-acetyltransferase
L2D31_13485	COG0517	IMP dehydrogenase activity
L2D31_13490	COG0123	including yeast histone deacetylase and acetoin utilization protein
L2D31_13495	COG1609	Transcriptional regulator
L2D31_13500	COG1605	Chorismate mutase
L2D31_13500	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
L2D31_13505	COG3118	belongs to the thioredoxin family
L2D31_13510	COG4980	gas vesicle protein
L2D31_13515	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
L2D31_13520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
L2D31_13525	COG1674	ftsk spoiiie
L2D31_13530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
L2D31_13535	COG4848	Belongs to the UPF0354 family
L2D31_13540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2D31_13555	COG1363	Peptidase, m42
L2D31_13560	COG5584	Small secreted protein
L2D31_13565	COG0281	malic enzyme
L2D31_13570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
L2D31_13575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
L2D31_13585	COG0510	thiamine kinase activity
L2D31_13590	COG1597	lipid kinase activity
L2D31_13600	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
L2D31_13605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
L2D31_13610	COG3340	Belongs to the peptidase S51 family
L2D31_13615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
L2D31_13620	COG2252	PERMEase
L2D31_13625	COG1349	DNA-binding transcription factor activity
L2D31_13630	COG1187	pseudouridine synthase activity
L2D31_13635	COG2244	polysaccharide biosynthetic process
L2D31_13640	COG2081	HI0933 family
L2D31_13650	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
L2D31_13655	COG3196	Protein conserved in bacteria
L2D31_13665	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
L2D31_13670	COG5578	integral membrane protein
L2D31_13675	COG0673	inositol 2-dehydrogenase activity
L2D31_13680	COG1653	transport
L2D31_13685	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
L2D31_13690	COG4209	transmembrane transport
L2D31_13695	COG2207	Transcriptional regulator
L2D31_13700	COG1733	regulation of RNA biosynthetic process
L2D31_13705	COG2814	Major facilitator Superfamily
L2D31_13710	COG0656	L-ascorbic acid biosynthetic process
L2D31_13715	COG1653	transport
L2D31_13720	COG0395	ABC-type sugar transport system, permease component
L2D31_13725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2D31_13730	COG1073	alpha beta
L2D31_13735	COG0495	leucyl-tRNA aminoacylation
L2D31_13745	COG1366	Belongs to the anti-sigma-factor antagonist family
L2D31_13745	COG2202	Pas domain
L2D31_13750	COG2433	Pfam Transposase IS66
L2D31_13755	COG0577	efflux transmembrane transporter activity
L2D31_13760	COG1136	(ABC) transporter
L2D31_13770	COG1131	(ABC) transporter
L2D31_13775	COG1725	Transcriptional regulator
L2D31_13800	COG1242	4 iron, 4 sulfur cluster binding
L2D31_13805	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
L2D31_13810	COG4326	sporulation control protein
L2D31_13820	COG2267	carboxylic ester hydrolase activity
L2D31_13825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
L2D31_13830	COG0367	asparagine synthase
L2D31_13835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
L2D31_13840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
L2D31_13850	COG1506	peptidase
L2D31_13855	COG1233	COG1233 Phytoene dehydrogenase and related
L2D31_13875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
L2D31_13880	COG1116	anion transmembrane transporter activity
L2D31_13885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
L2D31_13890	COG0494	nUDIX hydrolase
L2D31_13895	COG2310	stress, protein
L2D31_13910	COG4824	toxin secretion phage lysis holin
L2D31_13920	COG0783	Belongs to the Dps family
L2D31_13935	COG1854	S-ribosylhomocysteine lyase activity
L2D31_13940	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
L2D31_13945	COG0288	reversible hydration of carbon dioxide
L2D31_13950	COG0803	Belongs to the bacterial solute-binding protein 9 family
L2D31_13950	COG3443	Belongs to the bacterial solute-binding protein 9 family
L2D31_13960	COG1271	oxidase subunit
L2D31_13965	COG1294	oxidase, subunit
L2D31_13980	COG4948	Mandelate Racemase Muconate Lactonizing
L2D31_13985	COG0318	PFAM AMP-dependent synthetase and ligase
L2D31_13990	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
L2D31_13995	COG0596	Alpha beta hydrolase
L2D31_14000	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
L2D31_14005	COG1169	isochorismate synthase
L2D31_14010	COG1575	Belongs to the MenA family. Type 1 subfamily
L2D31_14015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
L2D31_14145	COG3859	Proton-coupled thiamine transporter YuaJ
L2D31_14150	COG1247	-acetyltransferase
L2D31_14155	COG3339	Conserved Protein
L2D31_14160	COG0772	Belongs to the SEDS family
L2D31_14165	COG0772	Belongs to the SEDS family
L2D31_14170	COG2268	Band 7 protein
L2D31_14175	COG1585	Membrane protein implicated in regulation of membrane protease activity
L2D31_14180	COG2318	DinB family
L2D31_14185	COG1454	alcohol dehydrogenase
L2D31_14190	COG1012	belongs to the aldehyde dehydrogenase family
L2D31_14195	COG1510	regulation of RNA biosynthetic process
L2D31_14210	COG3409	Peptidoglycan-binding domain 1 protein
L2D31_14210	COG5632	N-Acetylmuramoyl-L-alanine amidase
L2D31_14265	COG3778	Protein conserved in bacteria
L2D31_14270	COG3299	homolog of phage Mu protein gp47
L2D31_14275	COG3628	GPW Gp25 family protein
L2D31_14285	COG4193	domain, Protein
L2D31_14290	COG1652	LysM domain
L2D31_14295	COG3953	SLT domain
L2D31_14295	COG5280	Phage tail tape measure protein TP901
L2D31_14295	COG3953	SLT domain
L2D31_14295	COG5280	Phage tail tape measure protein TP901
L2D31_14350	COG4653	Phage capsid family
L2D31_14355	COG0338	D12 class N6 adenine-specific DNA methyltransferase
L2D31_14360	COG5518	Phage portal protein
L2D31_14365	COG1783	phage Terminase large subunit
L2D31_14370	COG5484	DNA packaging
L2D31_14375	COG1595	DNA-templated transcription, initiation
L2D31_14385	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
L2D31_14405	COG1396	sequence-specific DNA binding
L2D31_14415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
L2D31_14430	COG0628	permease
L2D31_14440	COG0673	inositol 2-dehydrogenase activity
L2D31_14445	COG0693	protein deglycase activity
L2D31_14450	COG0840	transmembrane signaling receptor activity
L2D31_14455	COG0840	transmembrane signaling receptor activity
L2D31_14460	COG0840	transmembrane signaling receptor activity
L2D31_14465	COG0840	transmembrane signaling receptor activity
L2D31_14480	COG2070	2-Nitropropane dioxygenase
L2D31_14485	COG0432	Pfam Uncharacterised protein family UPF0047
L2D31_14490	COG1253	flavin adenine dinucleotide binding
L2D31_14495	COG2738	Putative neutral zinc metallopeptidase
L2D31_14505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
L2D31_14520	COG0166	Belongs to the GPI family
L2D31_14525	COG1979	alcohol dehydrogenase
L2D31_14530	COG1979	alcohol dehydrogenase
L2D31_14535	COG2155	Conserved Protein
L2D31_14540	COG1098	S1 RNA binding domain
L2D31_14545	COG0436	Aminotransferase
L2D31_14550	COG1522	sequence-specific DNA binding
L2D31_14555	COG2267	carboxylic ester hydrolase activity
L2D31_14570	COG2205	protein histidine kinase activity
L2D31_14585	COG5018	Exonuclease
L2D31_14590	COG2814	Major facilitator Superfamily
L2D31_14595	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2D31_14600	COG3011	Protein conserved in bacteria
L2D31_14610	COG3290	protein histidine kinase activity
L2D31_14615	COG4565	transcriptional regulatory protein
L2D31_14620	COG1744	ABC transporter substrate-binding protein PnrA-like
L2D31_14625	COG3845	ABC transporter
L2D31_14630	COG4603	Belongs to the binding-protein-dependent transport system permease family
L2D31_14635	COG1079	Belongs to the binding-protein-dependent transport system permease family
L2D31_14640	COG3493	citrate carrier protein
L2D31_14650	COG2111	Na H antiporter
L2D31_14650	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
L2D31_14655	COG2111	Na H antiporter
L2D31_14660	COG1006	Multisubunit Na H antiporter MnhC subunit
L2D31_14665	COG0651	ATP synthesis coupled electron transport
L2D31_14670	COG1863	multisubunit Na H antiporter MnhE subunit
L2D31_14675	COG2212	antiporter activity
L2D31_14680	COG1320	monovalent cation:proton antiporter activity
L2D31_14685	COG2050	protein possibly involved in aromatic compounds catabolism
L2D31_14690	COG2197	response regulator
L2D31_14695	COG4585	Histidine kinase
L2D31_14705	COG0142	geranyltranstransferase activity
L2D31_14720	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
L2D31_14725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
L2D31_14730	COG1335	isochorismatase
L2D31_14735	COG5506	Protein of unknown function (DUF1694)
L2D31_14755	COG0628	permease
L2D31_14770	COG1418	mRNA catabolic process
L2D31_14775	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_14785	COG1511	domain protein
L2D31_14790	COG0433	COG0433 Predicted ATPase
L2D31_14790	COG1674	ftsk spoiiie
L2D31_14795	COG4499	WXG100 protein secretion system (Wss), protein YukC
L2D31_14800	COG5417	Belongs to the EsaB family
L2D31_14805	COG4842	Belongs to the WXG100 family
L2D31_14810	COG2508	Transcriptional regulator
L2D31_14810	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
L2D31_14815	COG0686	Belongs to the AlaDH PNT family
L2D31_14820	COG1268	BioY protein
L2D31_14825	COG2056	Na+-H+ antiporter family
L2D31_14830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
L2D31_14840	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
L2D31_14845	COG3584	3D domain protein
L2D31_14860	COG1252	NADH dehydrogenase
L2D31_14865	COG0492	ferredoxin-NADP+ reductase activity
L2D31_14885	COG0316	Belongs to the HesB IscA family
L2D31_14890	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
L2D31_14895	COG4844	belongs to the
L2D31_14900	COG1252	NADH dehydrogenase
L2D31_14910	COG4837	Protein of unknown function (DUF1462)
L2D31_14920	COG4946	Tricorn protease homolog
L2D31_14920	COG0823	Involved in the tonB-independent uptake of proteins
L2D31_14920	COG1506	peptidase
L2D31_14925	COG0083	homoserine kinase activity
L2D31_14930	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
L2D31_14935	COG0460	homoserine dehydrogenase
L2D31_14940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L2D31_14945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
L2D31_14950	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
L2D31_14955	COG0647	UMP catabolic process
L2D31_14960	COG2445	Protein of unknown function DUF86
L2D31_14965	COG4470	Protein conserved in bacteria
L2D31_14975	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
L2D31_14980	COG0739	heme binding
L2D31_15000	COG3377	Domain of unknown function (DUF1805)
L2D31_15005	COG0737	Belongs to the 5'-nucleotidase family
L2D31_15010	COG1801	Protein of unknown function DUF72
L2D31_15015	COG2508	Transcriptional regulator
L2D31_15020	COG2140	Oxalate decarboxylase
L2D31_15025	COG2814	Major facilitator Superfamily
L2D31_15030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
L2D31_15035	COG2356	endonuclease I
L2D31_15045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2D31_15050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2D31_15055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L2D31_15080	COG0642	Histidine kinase
L2D31_15080	COG5002	protein histidine kinase activity
L2D31_15085	COG0745	RESPONSE REGULATOR receiver
L2D31_15090	COG2311	Membrane
L2D31_15105	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
L2D31_15110	COG1090	epimerase
L2D31_15115	COG1309	transcriptional regulator
L2D31_15125	COG0719	Fe-S assembly protein
L2D31_15130	COG0822	iron-sulfur transferase activity
L2D31_15135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2D31_15140	COG0719	Fe-S assembly protein
L2D31_15145	COG0396	ATPase activity
L2D31_15155	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
L2D31_15160	COG1464	Belongs to the NlpA lipoprotein family
L2D31_15165	COG2011	ABC-type metal ion transport system permease component
L2D31_15170	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
L2D31_15180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
L2D31_15185	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
L2D31_15195	COG0509	glycine decarboxylation via glycine cleavage system
L2D31_15200	COG1393	Belongs to the ArsC family
L2D31_15205	COG1960	acyl-CoA dehydrogenase activity
L2D31_15210	COG0183	Belongs to the thiolase family
L2D31_15215	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2D31_15215	COG1024	Enoyl-CoA hydratase
L2D31_15230	COG5577	PFAM Coat F domain
L2D31_15240	COG1120	ATPase activity
L2D31_15250	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_15255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2D31_15260	COG0745	RESPONSE REGULATOR receiver
L2D31_15265	COG2205	protein histidine kinase activity
L2D31_15265	COG2770	Histidine kinase
L2D31_15275	COG1309	transcriptional regulator
L2D31_15285	COG0114	fumarate hydratase activity
L2D31_15295	COG0697	spore germination
L2D31_15300	COG0814	amino acid
L2D31_15315	COG2197	response regulator
L2D31_15320	COG4585	Histidine kinase
L2D31_15325	COG4758	membrane
L2D31_15335	COG1842	Phage shock protein A
L2D31_15340	COG4758	membrane
L2D31_15350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2D31_15355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L2D31_15360	COG0492	ferredoxin-NADP+ reductase activity
L2D31_15365	COG2096	Adenosyltransferase
L2D31_15370	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_15375	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
L2D31_15400	COG1454	alcohol dehydrogenase
L2D31_15405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
L2D31_15410	COG1120	ATPase activity
L2D31_15415	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2D31_15420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L2D31_15430	COG2721	sulfolactate sulfo-lyase activity
L2D31_15435	COG0246	Mannitol dehydrogenase
L2D31_15440	COG1609	Transcriptional regulator
L2D31_15445	COG1904	glucuronate isomerase
L2D31_15450	COG2205	protein histidine kinase activity
L2D31_15455	COG0745	RESPONSE REGULATOR receiver
L2D31_15460	COG1120	ATPase activity
L2D31_15465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2D31_15470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2D31_15475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L2D31_15480	COG0531	amino acid
L2D31_15495	COG1988	membrane-bound metal-dependent
L2D31_15500	COG1368	sulfuric ester hydrolase activity
L2D31_15505	COG0725	ABC transporter, periplasmic molybdate-binding protein
L2D31_15510	COG4149	molybdate abc transporter
L2D31_15515	COG0656	L-ascorbic acid biosynthetic process
L2D31_15520	COG1940	carbohydrate kinase activity
L2D31_15525	COG0025	NhaP-type Na H and K H
L2D31_15530	COG2860	membrane
L2D31_15535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
L2D31_15540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
L2D31_15545	COG2217	Heavy metal translocating P-type atpase
L2D31_15550	COG1121	(ABC) transporter
L2D31_15555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
L2D31_15560	COG0803	Belongs to the bacterial solute-binding protein 9 family
L2D31_15570	COG3226	Transcriptional regulator
L2D31_15575	COG0784	Response regulator, receiver
L2D31_15580	COG4191	Histidine kinase
L2D31_15585	COG1027	Aspartate ammonia-lyase
L2D31_15595	COG2217	Heavy metal translocating P-type atpase
L2D31_15600	COG2608	mercury ion transmembrane transporter activity
L2D31_15605	COG1937	Protein conserved in bacteria
L2D31_15635	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
L2D31_15640	COG0557	exoribonuclease II activity
L2D31_15645	COG1647	Serine aminopeptidase, S33
L2D31_15650	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
L2D31_15655	COG2002	toxin-antitoxin pair type II binding
L2D31_15660	COG1476	TRANSCRIPTIONal
L2D31_15665	COG1396	sequence-specific DNA binding
L2D31_15670	COG1396	sequence-specific DNA binding
L2D31_15675	COG1733	regulation of RNA biosynthetic process
L2D31_15680	COG1174	glycine betaine transport
L2D31_15685	COG1732	Glycine betaine
L2D31_15690	COG1174	glycine betaine transport
L2D31_15695	COG0517	IMP dehydrogenase activity
L2D31_15695	COG1125	glycine betaine transport
L2D31_15700	COG1510	regulation of RNA biosynthetic process
L2D31_15705	COG2095	MarC family integral membrane protein
L2D31_15715	COG0456	acetyltransferase
L2D31_15735	COG1131	(ABC) transporter
L2D31_15745	COG0148	phosphopyruvate hydratase activity
L2D31_15750	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
L2D31_15755	COG0149	triose-phosphate isomerase activity
L2D31_15760	COG0126	phosphoglycerate kinase activity
L2D31_15765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
L2D31_15770	COG2390	Transcriptional regulator
L2D31_15775	COG0833	amino acid
L2D31_15780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
L2D31_15785	COG3829	transcription factor binding
L2D31_15790	COG2186	Transcriptional regulator
L2D31_15795	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
L2D31_15805	COG0534	Mate efflux family protein
L2D31_15810	COG4608	Belongs to the ABC transporter superfamily
L2D31_15815	COG0444	Belongs to the ABC transporter superfamily
L2D31_15820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
L2D31_15825	COG0601	transmembrane transport
L2D31_15830	COG0747	negative chemotaxis
L2D31_15835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L2D31_15840	COG0110	maltose O-acetyltransferase activity
L2D31_15845	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
L2D31_15850	COG2244	polysaccharide biosynthetic process
L2D31_15855	COG5039	Polysaccharide pyruvyl transferase
L2D31_15860	COG1216	Glycosyl transferase, family 2
L2D31_15870	COG0438	transferase activity, transferring glycosyl groups
L2D31_15875	COG1215	transferase activity, transferring glycosyl groups
L2D31_15880	COG0438	transferase activity, transferring glycosyl groups
L2D31_15885	COG1086	Polysaccharide biosynthesis protein
L2D31_15890	COG0489	protein tyrosine kinase activity
L2D31_15895	COG3944	biosynthesis protein
L2D31_15900	COG1396	sequence-specific DNA binding
L2D31_15910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L2D31_15915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2D31_15920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2D31_15925	COG0726	polysaccharide deacetylase
L2D31_15930	COG0488	(ABC) transporter
L2D31_15950	COG0601	transmembrane transport
L2D31_15955	COG0747	negative chemotaxis
L2D31_15960	COG1819	glycosyl
L2D31_15965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L2D31_15980	COG0740	serine-type endopeptidase activity
L2D31_15985	COG1611	Belongs to the LOG family
L2D31_15990	COG1694	Mazg nucleotide pyrophosphohydrolase
L2D31_15995	COG0659	secondary active sulfate transmembrane transporter activity
L2D31_16000	COG0288	reversible hydration of carbon dioxide
L2D31_16005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
L2D31_16015	COG1301	dicarboxylic acid transport
L2D31_16020	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
L2D31_16030	COG2162	N-hydroxyarylamine O-acetyltransferase activity
L2D31_16035	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2D31_16040	COG1481	regulation of sporulation
L2D31_16045	COG0391	Required for morphogenesis under gluconeogenic growth conditions
L2D31_16050	COG1660	Displays ATPase and GTPase activities
L2D31_16055	COG1051	belongs to the nudix hydrolase family
L2D31_16060	COG0492	ferredoxin-NADP+ reductase activity
L2D31_16065	COG0791	NLP P60 protein
L2D31_16065	COG3883	PFAM NLP P60 protein
L2D31_16070	COG0457	Tetratricopeptide repeat
L2D31_16075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
L2D31_16075	COG0140	phosphoribosyl-ATP diphosphatase activity
L2D31_16080	COG0107	imidazoleglycerol-phosphate synthase activity
L2D31_16085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
L2D31_16090	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
L2D31_16095	COG0131	Imidazoleglycerol-phosphate dehydratase
L2D31_16100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
L2D31_16105	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
L2D31_16110	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
L2D31_16115	COG4990	cell redox homeostasis
L2D31_16125	COG2910	NAD(P)H-binding
L2D31_16130	COG1959	2 iron, 2 sulfur cluster binding
L2D31_16135	COG0110	maltose O-acetyltransferase activity
L2D31_16140	COG0546	phosphoglycolate phosphatase activity
L2D31_16145	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
L2D31_16150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
L2D31_16155	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
L2D31_16160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
L2D31_16165	COG0363	glucosamine-6-phosphate deaminase activity
L2D31_16170	COG2188	Transcriptional regulator
L2D31_16175	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
L2D31_16180	COG1950	PFAM Membrane protein of
L2D31_16185	COG1983	PspC domain protein
L2D31_16190	COG3595	metallopeptidase activity
L2D31_16205	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
L2D31_16215	COG4897	Protein conserved in bacteria
L2D31_16220	COG0574	Belongs to the PEP-utilizing enzyme family
L2D31_16220	COG3848	Pyruvate phosphate dikinase
L2D31_16225	COG1309	transcriptional regulator
L2D31_16230	COG2814	Major facilitator Superfamily
L2D31_16240	COG0745	RESPONSE REGULATOR receiver
L2D31_16245	COG5002	protein histidine kinase activity
L2D31_16250	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
L2D31_16255	COG0463	Glycosyl transferase, family 2
L2D31_16260	COG1113	amino acid transport
L2D31_16265	COG0778	Nitroreductase
L2D31_16270	COG1733	regulation of RNA biosynthetic process
L2D31_16275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2D31_16285	COG0793	Belongs to the peptidase S41A family
L2D31_16285	COG3409	Peptidoglycan-binding domain 1 protein
L2D31_16290	COG0730	response to heat
L2D31_16295	COG3883	PFAM NLP P60 protein
L2D31_16295	COG0791	NLP P60 protein
L2D31_16300	COG2177	Part of the ABC transporter FtsEX involved in
L2D31_16305	COG2884	Cell division ATP-binding protein ftsE
L2D31_16310	COG2010	Cytochrome c
L2D31_16315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
L2D31_16335	COG0653	protein targeting
L2D31_16340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
L2D31_16345	COG0840	transmembrane signaling receptor activity
L2D31_16360	COG1516	flagellar protein fliS
L2D31_16365	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
L2D31_16370	COG1334	flagellar protein FlaG
L2D31_16375	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
L2D31_16380	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
L2D31_16390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
L2D31_16395	COG4786	Flagellar basal body rod
L2D31_16395	COG1256	bacterial-type flagellum assembly
L2D31_16400	COG3418	PFAM FlgN family protein
L2D31_16415	COG1040	competence protein
L2D31_16425	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
L2D31_16430	COG1307	EDD domain protein, DegV family
L2D31_16435	COG2197	response regulator
L2D31_16440	COG4585	Histidine kinase
L2D31_16445	COG1739	Uncharacterized protein family UPF0029
L2D31_16450	COG1316	TRANSCRIPTIONal
L2D31_16455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
L2D31_16460	COG0438	transferase activity, transferring glycosyl groups
L2D31_16465	COG1215	transferase activity, transferring glycosyl groups
L2D31_16470	COG3206	protein involved in exopolysaccharide biosynthesis
L2D31_16475	COG3307	-O-antigen
L2D31_16480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
L2D31_16485	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L2D31_16490	COG0438	transferase activity, transferring glycosyl groups
L2D31_16490	COG0297	glycogen (starch) synthase activity
L2D31_16495	COG2244	polysaccharide biosynthetic process
L2D31_16510	COG2247	cell wall binding repeat
L2D31_16510	COG0860	N-Acetylmuramoyl-L-alanine amidase
L2D31_16515	COG0860	N-Acetylmuramoyl-L-alanine amidase
L2D31_16515	COG2247	cell wall binding repeat
L2D31_16520	COG2247	cell wall binding repeat
L2D31_16520	COG2385	sporulation resulting in formation of a cellular spore
L2D31_16530	COG1316	TRANSCRIPTIONal
L2D31_16535	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
L2D31_16540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
L2D31_16545	COG1134	teichoic acid transport
L2D31_16550	COG1682	transport, permease protein
L2D31_16555	COG1216	Glycosyl transferase, family 2
L2D31_16565	COG1181	Belongs to the D-alanine--D-alanine ligase family
L2D31_16570	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L2D31_16580	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L2D31_16585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L2D31_16595	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
L2D31_16600	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
L2D31_16605	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L2D31_16610	COG4193	domain, Protein
L2D31_16615	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L2D31_16620	COG1482	cell wall glycoprotein biosynthetic process
L2D31_16630	COG1175	transmembrane transport
L2D31_16635	COG1653	transport
L2D31_16640	COG2197	response regulator
L2D31_16645	COG2972	Histidine kinase
L2D31_16655	COG0454	-acetyltransferase
L2D31_16660	COG0800	Aldolase
L2D31_16665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2D31_16670	COG1609	Transcriptional regulator
L2D31_16675	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
L2D31_16680	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_16685	COG0697	spore germination
L2D31_16690	COG0814	amino acid
L2D31_16705	COG2814	Major facilitator Superfamily
L2D31_16710	COG1316	TRANSCRIPTIONal
L2D31_16715	COG0561	phosphatase activity
L2D31_16720	COG0791	NLP P60 protein
L2D31_16730	COG2843	Capsule synthesis protein
L2D31_16740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
L2D31_16745	COG0697	spore germination
L2D31_16760	COG1609	Transcriptional regulator
L2D31_16765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
L2D31_16770	COG1869	D-ribose catabolic process
L2D31_16775	COG1129	ABC transporter
L2D31_16780	COG1172	Belongs to the binding-protein-dependent transport system permease family
L2D31_16785	COG1879	ABC-type sugar transport system periplasmic component
L2D31_16790	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
L2D31_16795	COG0583	DNA-binding transcription factor activity
L2D31_16800	COG0028	Belongs to the TPP enzyme family
L2D31_16805	COG3527	Alpha-acetolactate decarboxylase
L2D31_16810	COG1522	sequence-specific DNA binding
L2D31_16815	COG2059	Chromate
L2D31_16820	COG2059	Chromate
L2D31_16825	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
L2D31_16835	COG4715	Zinc finger, swim domain protein
L2D31_16840	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
L2D31_16845	COG1366	Belongs to the anti-sigma-factor antagonist family
L2D31_16845	COG2202	Pas domain
L2D31_16850	COG0561	phosphatase activity
L2D31_16865	COG1970	mechanosensitive ion channel activity
L2D31_16870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
L2D31_16875	COG0457	Tetratricopeptide repeat
L2D31_16880	COG4786	Flagellar basal body rod
L2D31_16885	COG4786	Flagellar basal body rod
L2D31_16890	COG1077	Cell shape determining protein MreB Mrl
L2D31_16895	COG1609	Transcriptional regulator
L2D31_16900	COG1846	Transcriptional regulator
L2D31_16905	COG2814	Major facilitator Superfamily
L2D31_16910	COG0671	phosphoesterase, PA-phosphatase related
L2D31_16915	COG0477	Major facilitator Superfamily
L2D31_16920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2D31_16925	COG0765	amino acid transport
L2D31_16930	COG1126	abc transporter atp-binding protein
L2D31_16935	COG0004	ammonium transporteR
L2D31_16940	COG0347	Belongs to the P(II) protein family
L2D31_16945	COG0739	heme binding
L2D31_16950	COG1247	-acetyltransferase
L2D31_16985	COG0267	Belongs to the bacterial ribosomal protein bL33 family
L2D31_16990	COG0523	cobalamin synthesis protein
L2D31_16995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
L2D31_17000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
L2D31_17005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
L2D31_17010	COG2223	nitrite transmembrane transporter activity
L2D31_17020	COG2304	oxidoreductase activity
L2D31_17025	COG2304	oxidoreductase activity
L2D31_17030	COG2385	sporulation resulting in formation of a cellular spore
L2D31_17035	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2D31_17045	COG4836	Membrane
L2D31_17055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
L2D31_17060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
L2D31_17065	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
L2D31_17070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
L2D31_17075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L2D31_17080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
L2D31_17085	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
L2D31_17090	COG0356	it plays a direct role in the translocation of protons across the membrane
L2D31_17100	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
L2D31_17105	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
L2D31_17110	COG4475	Protein of unknown function (DUF436)
L2D31_17115	COG0698	ribose 5-phosphate isomerase
L2D31_17120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
L2D31_17125	COG1971	Probably functions as a manganese efflux pump
L2D31_17130	COG0009	L-threonylcarbamoyladenylate synthase
L2D31_17135	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
L2D31_17150	COG2890	protein-(glutamine-N5) methyltransferase activity
L2D31_17155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
L2D31_17160	COG0789	Transcriptional regulator
L2D31_17165	COG0679	Auxin Efflux Carrier
L2D31_17170	COG0281	malic enzyme
L2D31_17175	COG1435	thymidine kinase activity
L2D31_17180	COG0254	rRNA binding
L2D31_17185	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
L2D31_17190	COG1494	fructose-1,6-bisphosphatase
L2D31_17195	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
L2D31_17200	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
L2D31_17205	COG0191	fructose-bisphosphate aldolase activity
L2D31_17210	COG2204	response regulator
L2D31_17215	COG4821	SIS domain
L2D31_17220	COG0504	CTP synthase activity
L2D31_17225	COG3343	RNA polymerase activity
L2D31_17240	COG1960	acyl-CoA dehydrogenase activity
L2D31_17245	COG1960	acyl-CoA dehydrogenase activity
L2D31_17250	COG1250	3-hydroxyacyl-CoA dehydrogenase
L2D31_17255	COG0183	Belongs to the thiolase family
L2D31_17260	COG0247	lactate metabolic process
L2D31_17260	COG2181	nitrate reductase activity
L2D31_17265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2D31_17270	COG4294	response to UV
L2D31_17280	COG1619	proteins homologs of microcin C7 resistance protein MccF
L2D31_17285	COG1132	(ABC) transporter
L2D31_17290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
L2D31_17295	COG1619	proteins homologs of microcin C7 resistance protein MccF
L2D31_17305	COG0018	arginyl-trna synthetase
L2D31_17310	COG4506	Protein conserved in bacteria
L2D31_17320	COG0010	Belongs to the arginase family
L2D31_17325	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
L2D31_17330	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
L2D31_17340	COG1994	Peptidase M50
L2D31_17345	COG1942	4-Oxalocrotonate Tautomerase
L2D31_17355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2D31_17360	COG0583	DNA-binding transcription factor activity
L2D31_17365	COG0431	NADPH-dependent FMN reductase
L2D31_17370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2D31_17375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
L2D31_17380	COG0454	-acetyltransferase
L2D31_17385	COG0765	amino acid transport
L2D31_17395	COG0765	amino acid transport
L2D31_17400	COG1126	abc transporter atp-binding protein
L2D31_17405	COG3465	dGTPase activity
L2D31_17410	COG1078	dGTPase activity
L2D31_17415	COG4844	belongs to the
L2D31_17495	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
L2D31_17505	COG0280	phosphate acetyltransferase
L2D31_17515	COG2814	Major facilitator Superfamily
L2D31_17520	COG1522	sequence-specific DNA binding
L2D31_17525	COG2814	Major facilitator Superfamily
L2D31_17530	COG0077	Prephenate dehydratase
L2D31_17535	COG1917	Cupin 2, conserved barrel domain protein
L2D31_17540	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_17545	COG0151	Belongs to the GarS family
L2D31_17550	COG0436	Aminotransferase
L2D31_17555	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_17560	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
L2D31_17565	COG1091	dTDP-4-dehydrorhamnose reductase activity
L2D31_17570	COG1088	dTDP-glucose 4,6-dehydratase activity
L2D31_17575	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
L2D31_17580	COG3980	spore coat polysaccharide biosynthesis protein
L2D31_17585	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
L2D31_17590	COG2089	acid synthase
L2D31_17595	COG0456	acetyltransferase
L2D31_17600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L2D31_17605	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
L2D31_17610	COG0463	Glycosyl transferase, family 2
L2D31_17630	COG2363	Small membrane protein
L2D31_17635	COG2233	PERMEase
L2D31_17645	COG1012	belongs to the aldehyde dehydrogenase family
L2D31_17650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
L2D31_17655	COG1216	Glycosyl transferase, family 2
L2D31_17665	COG0351	phosphomethylpyrimidine kinase
L2D31_17695	COG1621	beta-fructofuranosidase activity
L2D31_17700	COG1263	PTS System
L2D31_17700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2D31_17705	COG3711	transcriptional antiterminator
L2D31_17715	COG1404	Belongs to the peptidase S8 family
L2D31_17725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
L2D31_17730	COG0778	Nitroreductase
L2D31_17735	COG0772	Belongs to the SEDS family
L2D31_17745	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
L2D31_17750	COG1845	cytochrome c oxidase, subunit III
L2D31_17755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
L2D31_17760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
L2D31_17770	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
L2D31_17775	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
L2D31_17780	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
L2D31_17795	COG2246	polysaccharide biosynthetic process
L2D31_17815	COG3162	membrane
L2D31_17820	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
L2D31_17835	COG0352	thiamine-phosphate diphosphorylase activity
L2D31_17840	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
L2D31_17845	COG0583	DNA-binding transcription factor activity
L2D31_17850	COG1380	Effector of murein hydrolase LrgA
L2D31_17855	COG1346	cytolysis
L2D31_17860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
L2D31_17865	COG0346	lactoylglutathione lyase activity
L2D31_17875	COG0765	amino acid transport
L2D31_17880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
L2D31_17885	COG0457	Tetratricopeptide repeat
L2D31_17895	COG2357	RelA SpoT domain protein
L2D31_17900	COG1172	Belongs to the binding-protein-dependent transport system permease family
L2D31_17905	COG1129	ABC transporter
L2D31_17915	COG3420	alginic acid biosynthetic process
L2D31_17920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
L2D31_17930	COG1486	melibiose metabolic process
L2D31_17935	COG1447	Phosphotransferase system cellobiose-specific component IIA
L2D31_17940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L2D31_17945	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L2D31_17950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2D31_17950	COG3711	transcriptional antiterminator
L2D31_17970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
L2D31_17985	COG1595	DNA-templated transcription, initiation
L2D31_17995	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
L2D31_18000	COG4988	ABC transporter
L2D31_18005	COG1294	oxidase, subunit
L2D31_18010	COG1271	oxidase subunit
L2D31_18025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
L2D31_18030	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
L2D31_18035	COG4509	Sortase family
L2D31_18060	COG5386	Cell surface protein
L2D31_18065	COG5386	Cell surface protein
L2D31_18070	COG1733	regulation of RNA biosynthetic process
L2D31_18075	COG2514	catechol 2,3-dioxygenase activity
L2D31_18080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2D31_18080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
L2D31_18085	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2D31_18085	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
L2D31_18095	COG0726	polysaccharide deacetylase
L2D31_18100	COG1447	Phosphotransferase system cellobiose-specific component IIA
L2D31_18105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L2D31_18110	COG2723	6-phospho-beta-galactosidase activity
L2D31_18115	COG1312	Catalyzes the dehydration of D-mannonate
L2D31_18120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
L2D31_18125	COG3711	transcriptional antiterminator
L2D31_18125	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
L2D31_18150	COG1757	Na H antiporter
L2D31_18155	COG1027	Aspartate ammonia-lyase
L2D31_18160	COG0252	asparaginase activity
L2D31_18165	COG1396	sequence-specific DNA binding
L2D31_18190	COG4842	Belongs to the WXG100 family
L2D31_18195	COG2195	Cleaves the N-terminal amino acid of tripeptides
L2D31_18210	COG1737	Transcriptional regulator
L2D31_18215	COG2084	Dehydrogenase
L2D31_18225	COG2610	gluconate transmembrane transporter activity
L2D31_18230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
L2D31_18235	COG2723	6-phospho-beta-galactosidase activity
L2D31_18240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2D31_18240	COG1263	PTS System
L2D31_18240	COG2190	(PTS) system
L2D31_18245	COG3711	transcriptional antiterminator
L2D31_18250	COG3878	Protein conserved in bacteria
L2D31_18260	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L2D31_18265	COG1122	ATPase activity
L2D31_18270	COG4721	ABC-type cobalt transport system, permease component
L2D31_18275	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
L2D31_18310	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
L2D31_18315	COG0778	Nitroreductase
L2D31_18320	COG1846	Transcriptional regulator
L2D31_18325	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
L2D31_18330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
L2D31_18335	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
L2D31_18340	COG2390	Transcriptional regulator
L2D31_18350	COG2755	lipolytic protein G-D-S-L family
L2D31_18350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
L2D31_18355	COG0477	Major facilitator Superfamily
L2D31_18365	COG2226	methyltransferase
L2D31_18375	COG0561	phosphatase activity
L2D31_18380	COG0789	Transcriptional regulator
L2D31_18385	COG0673	inositol 2-dehydrogenase activity
L2D31_18390	COG0840	transmembrane signaling receptor activity
L2D31_18395	COG1113	amino acid transport
L2D31_18400	COG4335	DNA alkylation repair
L2D31_18410	COG1070	Carbohydrate kinase
L2D31_18415	COG1737	Transcriptional regulator
L2D31_18455	COG0583	DNA-binding transcription factor activity
L2D31_18460	COG1609	Transcriptional regulator
L2D31_18465	COG2182	Extracellular solute-binding protein
L2D31_18470	COG1175	transmembrane transport
L2D31_18475	COG3833	ABC-type maltose transport systems, permease component
L2D31_18485	COG1874	Beta-galactosidase
L2D31_18520	COG2851	Citrate transporter
L2D31_18530	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
L2D31_18535	COG1131	(ABC) transporter
L2D31_18545	COG2824	Alkylphosphonate utilization operon protein PhnA
L2D31_18550	COG1929	Belongs to the glycerate kinase type-1 family
L2D31_18555	COG2610	gluconate transmembrane transporter activity
L2D31_18560	COG3835	regulator
L2D31_18565	COG1309	transcriptional regulator
L2D31_18570	COG2814	Major facilitator Superfamily
L2D31_18580	COG1136	(ABC) transporter
L2D31_18585	COG0457	Tetratricopeptide repeat
L2D31_18590	COG3711	transcriptional antiterminator
L2D31_18595	COG2723	6-phospho-beta-galactosidase activity
L2D31_18600	COG1263	PTS System
L2D31_18600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
L2D31_18600	COG2190	(PTS) system
L2D31_18625	COG0494	nUDIX hydrolase
L2D31_18640	COG1113	amino acid transport
L2D31_18645	COG1609	Transcriptional regulator
L2D31_18650	COG2814	Major facilitator Superfamily
L2D31_18655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
L2D31_18660	COG2814	Major facilitator Superfamily
L2D31_18675	COG5444	nuclease activity
L2D31_18695	COG2723	6-phospho-beta-galactosidase activity
L2D31_18705	COG2188	Transcriptional regulator
L2D31_18720	COG0384	phenazine biosynthesis protein PhzF
L2D31_18725	COG0583	DNA-binding transcription factor activity
L2D31_18745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
L2D31_18750	COG5002	protein histidine kinase activity
L2D31_18750	COG3850	Histidine kinase
L2D31_18760	COG2409	Drug exporters of the RND superfamily
L2D31_18780	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
L2D31_18790	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
L2D31_18800	COG4720	Psort location CytoplasmicMembrane, score
L2D31_18820	COG0456	acetyltransferase
L2D31_18825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
L2D31_18830	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
L2D31_18835	COG4853	Protein conserved in bacteria
L2D31_18840	COG4863	YycH protein
L2D31_18845	COG5002	protein histidine kinase activity
L2D31_18850	COG0745	RESPONSE REGULATOR receiver
L2D31_18875	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
L2D31_18885	COG2311	Membrane
L2D31_18890	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
L2D31_18895	COG1309	transcriptional regulator
L2D31_18900	COG2124	cytochrome p450
L2D31_18905	COG0346	lactoylglutathione lyase activity
L2D31_18910	COG0305	Participates in initiation and elongation during chromosome replication
L2D31_18925	COG2819	hydrolase of the alpha beta superfamily
L2D31_18930	COG1028	Short-chain dehydrogenase reductase Sdr
L2D31_18935	COG1169	isochorismate synthase
L2D31_18940	COG1021	2,3-dihydroxybenzoate-AMP ligase
L2D31_18945	COG1535	isochorismatase
L2D31_18945	COG3433	isochorismatase activity
L2D31_18950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
L2D31_18955	COG3251	PFAM MbtH domain protein
L2D31_18960	COG2207	Transcriptional regulator
L2D31_18960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L2D31_18965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
L2D31_18970	COG2819	hydrolase of the alpha beta superfamily
L2D31_18975	COG3093	addiction module antidote protein HigA
L2D31_18980	COG2807	transmembrane transport
L2D31_18985	COG0359	binds to the 23S rRNA
L2D31_18990	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
L2D31_18995	COG4241	membrane
L2D31_19000	COG1227	inorganic diphosphatase activity
L2D31_19010	COG1595	DNA-templated transcription, initiation
L2D31_19020	COG0753	catalase activity
L2D31_19025	COG0655	NAD(P)H dehydrogenase (quinone) activity
L2D31_19030	COG0400	carboxylic ester hydrolase activity
L2D31_19035	COG0346	lactoylglutathione lyase activity
L2D31_19040	COG1174	glycine betaine transport
L2D31_19045	COG0517	IMP dehydrogenase activity
L2D31_19045	COG1125	glycine betaine transport
L2D31_19050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
L2D31_19055	COG0629	single-stranded DNA binding
L2D31_19060	COG0360	Binds together with S18 to 16S ribosomal RNA
L2D31_19065	COG0012	GTP binding
L2D31_19070	COG4481	Protein conserved in bacteria
L2D31_19085	COG3949	Membrane
L2D31_19095	COG1475	DNA binding
L2D31_19100	COG1192	Involved in chromosome partitioning
L2D31_19110	COG1475	DNA binding
L2D31_19115	COG0357	Ribosomal RNA small subunit methyltransferase G
L2D31_19120	COG0445	tRNA wobble uridine modification
L2D31_19125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
L2D31_19130	COG1847	R3H domain protein
L2D31_19135	COG0706	membrane insertase activity
L2D31_19140	COG0594	ribonuclease P activity
L2D31_19145	COG0230	Belongs to the bacterial ribosomal protein bL34 family