locus-tag class description EJW27_00020 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EJW27_00055 ENOG4105FA0 parb-like partition protein EJW27_00060 ENOG4108ZDA Sporulation protein YyaC EJW27_00065 ENOG4105D8X mechanosensitive ion channel EJW27_00070 ENOG4105VDK protein, conserved in bacteria EJW27_00075 ENOG4105C3G gtp-binding protein EJW27_00085 ENOG4108UUM single-stranded DNA-binding protein EJW27_00095 ENOG4108XMW Membrane EJW27_00100 ENOG4105BZR domain protein EJW27_00110 ENOG4105CDU Replicative dna helicase EJW27_00140 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJW27_00145 ENOG4105BZU Histidine kinase EJW27_00160 ENOG4105Q2H domain protein EJW27_00165 ENOG4105C0H protease EJW27_00185 ENOG4105DPN Oligoendopeptidase f EJW27_00200 ENOG4105C1J atp-dependent rna helicase EJW27_00215 ENOG4108UT2 hemolysin iii EJW27_00220 ENOG4105CMR udp-glucose 4-epimerase EJW27_00230 ENOG4105IW1 AmiS UreI transporter EJW27_00240 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EJW27_00260 ENOG4107RGD Major Facilitator superfamily EJW27_00265 ENOG4108HRK Histidine kinase EJW27_00270 ENOG4105DY9 regulatoR EJW27_00275 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) EJW27_00285 ENOG4106F5Q Membrane EJW27_00290 ENOG4105E0X reductase EJW27_00300 ENOG41067SE Tetr family transcriptional regulator EJW27_00305 ENOG4105CKK Glycosyl transferase, family 2 EJW27_00325 ENOG4105C5H ABC transporter EJW27_00335 ENOG4105K64 Glycosyl transferase, family 2 EJW27_00340 ENOG4108S4H thioesterase Superfamily protein EJW27_00350 ENOG4106YBV Methyl-accepting chemotaxis EJW27_00355 ENOG4105EN6 Membrane EJW27_00375 ENOG41079KZ Major Facilitator Superfamily EJW27_00380 ENOG4105DY9 regulatoR EJW27_00385 ENOG4105D22 carbon starvation protein EJW27_00390 ENOG4105VCD cytoplasmic protein EJW27_00395 ENOG4105BZU Histidine kinase EJW27_00400 ENOG4105DWF phosphomethylpyrimidine kinase EJW27_00405 ENOG4105BZU Histidine kinase EJW27_00410 ENOG4105WH1 Two component transcriptional regulator luxr family EJW27_00445 ENOG4105D6E homoserine dehydrogenase EJW27_00460 ENOG41090WU lipolytic protein G-D-S-L family EJW27_00465 ENOG4105CJ1 ABC, transporter EJW27_00470 ENOG4108TU7 Inherit from COG: (ABC) transporter EJW27_00480 ENOG4105VCH membrane EJW27_00485 ENOG410667J hydrolase EJW27_00515 ENOG4108VKI Cell wall hydrolase EJW27_00525 ENOG4107UEZ chlorite dismutase EJW27_00530 ENOG4108IJ2 phosphate acetyltransferase EJW27_00540 ENOG4108VCI transcription factor, rsfa family EJW27_00550 ENOG4105DQ5 transport system permease protein EJW27_00555 ENOG4105EHG Permease protein EJW27_00560 ENOG4105E0A ABC, transporter EJW27_00565 ENOG4108MES Periplasmic binding protein EJW27_00570 ENOG4105DCI Phosphohydrolase EJW27_00575 ENOG41069HH 4-oxalocrotonate tautomerase EJW27_00580 ENOG4108Z4T Peptidase M50 EJW27_00585 ENOG4108XFG YwhD family EJW27_00590 ENOG4105BZ4 penicillin-binding protein EJW27_00595 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EJW27_00600 ENOG4107SWG transcriptional regulator MERR family EJW27_00605 ENOG4105DXB Major Facilitator superfamily EJW27_00615 ENOG4105CYW agmatinase EJW27_00635 ENOG410684U Domain of unknown function (DUF1934) EJW27_00645 ENOG4105EMN RNA polymerase sigma factor EJW27_00675 ENOG4105IIU Aminopeptidase EJW27_00680 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) EJW27_00685 ENOG4108M15 ABC transporter EJW27_00690 ENOG4105KCT ABC transporter EJW27_00695 ENOG4105BZU Histidine kinase EJW27_00725 ENOG4105BZU Histidine kinase EJW27_00750 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EJW27_00755 ENOG4105C1G acyl-Coa dehydrogenase EJW27_00760 ENOG4105C1G acyl-Coa dehydrogenase EJW27_00800 ENOG4105CBT Fructose-1,6-bisphosphatase EJW27_00805 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EJW27_00820 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EJW27_00825 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EJW27_00830 ENOG4108ZXQ stage ii sporulation protein r EJW27_00860 ENOG4107XC4 flavin reductase domain protein, FMN-binding EJW27_00865 ENOG4108VGI doxx family EJW27_00880 ENOG4108YZG isomerase EJW27_00910 ENOG41062M3 atp synthase EJW27_00915 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) EJW27_00970 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EJW27_00980 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain EJW27_01010 ENOG4105D65 subunit l EJW27_01020 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EJW27_01025 ENOG4106778 Protein of unknown function (DUF1146) EJW27_01045 ENOG4105DY9 regulatoR EJW27_01060 ENOG4105FRN stage II sporulation protein EJW27_01070 ENOG4105MT0 Sporulation transcriptional regulator spoiiid EJW27_01085 ENOG4107YJ4 chain length determinant protein EJW27_01090 ENOG4105HTX biosynthesis protein EJW27_01095 ENOG4107YJ4 chain length determinant protein EJW27_01100 ENOG4108RB3 Capsular polysaccharide biosynthesis protein EJW27_01105 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EJW27_01110 ENOG4105D3Q Sugar transferase EJW27_01115 ENOG4107S6X Glycosyl transferase, family 2 EJW27_01145 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase EJW27_01170 ENOG4108KGH TRANSCRIPTIONal EJW27_01180 ENOG4105CMR udp-glucose 4-epimerase EJW27_01185 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJW27_01205 ENOG4105CXY transporter EJW27_01225 ENOG4105C19 ABC transporter EJW27_01230 ENOG4107RBB ABC transporter, permease EJW27_01245 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJW27_01275 ENOG4105C0D helicase EJW27_01280 ENOG4105KBK Zinc finger, swim domain protein EJW27_01305 ENOG41069ER domain protein EJW27_01315 ENOG4105C94 Transporter EJW27_01320 ENOG4107R8N Glycosyl transferase, family 2 EJW27_01345 ENOG4105E0M Sulfatase EJW27_01360 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) EJW27_01405 ENOG4107RSM transcriptional regulator EJW27_01410 ENOG4105ECB domain protein EJW27_01430 ENOG4105VZJ PTS System EJW27_01440 ENOG4105VCP PTS System EJW27_01450 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EJW27_01460 ENOG4105CK1 PTS System EJW27_01465 ENOG4105VCP PTS System EJW27_01470 ENOG4105F8D glycoside hydrolase family 4 EJW27_01490 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EJW27_01505 ENOG4105C6Y Udp-glucose 6-dehydrogenase EJW27_01510 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EJW27_01520 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EJW27_01530 ENOG4105KVH Transcriptional regulator EJW27_01535 ENOG4105K4H Nlp p60 protein EJW27_01545 ENOG41081UC Inherit from COG: Competence protein EJW27_01550 ENOG4105VEQ Cold shock protein EJW27_01555 ENOG4105MS2 ribosomal subunit Interface protein EJW27_01585 ENOG4108RDQ ABC transporter EJW27_01615 ENOG4105CAK Cell division ATP-binding protein ftsE EJW27_01620 ENOG4105CRP Part of the ABC transporter FtsEX involved in EJW27_01625 ENOG4105CN1 protease EJW27_01650 ENOG4108WS4 fmn reductase EJW27_01660 ENOG4105DUM transcriptional regulator, lysR family EJW27_01680 ENOG4107TXC Transcriptional regulator EJW27_01690 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EJW27_01705 ENOG41086DT Membrane protein of unknown function EJW27_01725 ENOG4108S4C acetyltransferase EJW27_01735 ENOG4105C3M thioredoxin reductase EJW27_01745 ENOG4108Z4K mutator MutT protein EJW27_01755 ENOG4105CHW UPF0052 protein EJW27_01765 ENOG4105KRI phosphocarrier protein (HPr EJW27_01775 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EJW27_01780 ENOG4105H67 Protein of unknown function (DUF421) EJW27_01795 ENOG4105CZ3 stage V sporulation protein ad EJW27_01800 ENOG41090VF Stage v sporulation protein ac EJW27_01820 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJW27_01870 ENOG41067MG lrgb family EJW27_01875 ENOG4105XZU Preprotein translocase, subunit SecG EJW27_01885 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EJW27_01915 ENOG4105CM4 permease protein EJW27_01920 ENOG4108IPW abc transporter atp-binding protein EJW27_01935 ENOG4108MK9 spermidine N(1)-acetyltransferase EJW27_01940 ENOG4105C5H ABC transporter EJW27_01985 ENOG4105D4A Cell wall formation (By similarity) EJW27_01990 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EJW27_02005 ENOG4105KVH Transcriptional regulator EJW27_02010 ENOG4105F27 Major Facilitator EJW27_02015 ENOG4105CV8 reductase EJW27_02030 ENOG4108RYK Nad-dependent epimerase dehydratase EJW27_02050 ENOG4105D9N nucleoside EJW27_02085 ENOG4108RMU ferritin dps family protein EJW27_02095 ENOG4105NCW Trka-c domain protein EJW27_02100 ENOG4107S91 Sodium hydrogen exchanger EJW27_02105 ENOG4107T5V SNARE associated Golgi EJW27_02120 ENOG4105C2I pirin domain protein EJW27_02125 ENOG4105D4Y metalloprotease EJW27_02130 ENOG4105VG1 fes assembly suf system protein EJW27_02135 ENOG4105C8Q Methyl-accepting chemotaxis EJW27_02140 ENOG4105C8Q Methyl-accepting chemotaxis EJW27_02160 ENOG4105BZU Histidine kinase EJW27_02165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJW27_02170 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EJW27_02180 ENOG4107ZTW SNARE associated Golgi EJW27_02225 ENOG4107AYK membrAne EJW27_02235 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EJW27_02245 ENOG4107R7I amino acid EJW27_02250 ENOG4105F27 Major Facilitator EJW27_02265 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer EJW27_02285 ENOG4105DZ1 carboxypeptidase EJW27_02300 ENOG4105CHU acetyl-coa acetyltransferase EJW27_02305 ENOG4105C1G acyl-Coa dehydrogenase EJW27_02310 ENOG4108W8B Beta-lactamase domain protein EJW27_02355 ENOG41080E8 Transcriptional regulator, Spx MgsR family EJW27_02390 ENOG4108UMI ABC transporter, permease EJW27_02395 ENOG4105D01 (LipO)protein EJW27_02400 ENOG4105D01 (LipO)protein EJW27_02405 ENOG4105C3K feS assembly ATPase SufC EJW27_02410 ENOG4105JRK feS assembly protein SufD EJW27_02415 ENOG4105C9B Cysteine desulfurase EJW27_02420 ENOG4108UNV SUF system FeS assembly protein, NifU family EJW27_02425 ENOG4105DIW FeS assembly protein SUFB EJW27_02435 ENOG4107R8B 5'-nucleotidase EJW27_02440 ENOG4105KZD Domain of unknown function (DUF1805) EJW27_02450 ENOG4105FAA peptidase M23 EJW27_02475 ENOG41090T1 Membrane EJW27_02480 ENOG4107TXC Transcriptional regulator EJW27_02485 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) EJW27_02490 ENOG4105MMD transcriptional regulator EJW27_02510 ENOG4105CBT Fructose-1,6-bisphosphatase EJW27_02525 ENOG4105D4U had-superfamily hydrolase, subfamily iia EJW27_02540 ENOG4105DYS nad(p)h dehydrogenase (quinone) EJW27_02545 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EJW27_02560 ENOG4108W5N phosphatidylglycerophosphatase a EJW27_02575 ENOG41083MR nifu domain-containing protein EJW27_02600 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EJW27_02605 ENOG4105C4B ABC transporter, permease EJW27_02610 ENOG4108JJA ABC, transporter EJW27_02635 ENOG4108YX9 iron--sulfur cluster insertion protein erpA EJW27_02645 ENOG4108VQJ O-methyltransferase EJW27_02655 ENOG4105EWC Purine nucleoside phosphorylase EJW27_02680 ENOG4105CEP NADH dehydrogenase EJW27_02695 ENOG41069ER domain protein EJW27_02730 ENOG4105KA0 thioesterase Superfamily protein EJW27_02735 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) EJW27_02755 ENOG4107R3E Citrate transporter EJW27_02765 ENOG4105Y38 Kinase-associated protein B EJW27_02775 ENOG4105C87 Aminotransferase class I and II EJW27_02785 ENOG4108MUZ hydrolase EJW27_02790 ENOG4105C5I Dehydrogenase EJW27_02795 ENOG4108ZB6 transcriptional regulator AsnC family EJW27_02800 ENOG4105CHM Aminotransferase EJW27_02830 ENOG4107PBV potassium channel EJW27_02835 ENOG4105KT7 mgtC SapB transporter EJW27_02965 ENOG4105JVQ RNA Polymerase EJW27_02975 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EJW27_03035 ENOG4105VEQ Cold shock protein EJW27_03045 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EJW27_03050 ENOG4105E4F Isochorismate synthase EJW27_03060 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) EJW27_03065 ENOG4108IPT Naphthoate synthase EJW27_03075 ENOG4105DTQ mandelate racemase muconate lactonizing EJW27_03100 ENOG41069H0 dihydroorotase EC 3.5.2.3 EJW27_03120 ENOG4105FDP GntR family transcriptional regulator EJW27_03165 ENOG41086D8 Transcriptional regulator EJW27_03170 ENOG4105C19 ABC transporter EJW27_03185 ENOG4107ZTW SNARE associated Golgi EJW27_03225 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) EJW27_03230 ENOG4108UGV hypoxanthine phosphoribosyltransferase EJW27_03260 ENOG4105BZU Histidine kinase EJW27_03265 ENOG4105N67 Proton-coupled thiamine transporter YuaJ EJW27_03290 ENOG41087YS Phage shock protein A EJW27_03345 ENOG4108V2W Carbonate dehydratase EJW27_03415 ENOG4105D2X ABC transporter substrate-binding protein EJW27_03430 ENOG4107T7U Sulfatase EJW27_03435 ENOG4107S9D Alpha beta hydrolase EJW27_03440 ENOG4105BZU Histidine kinase EJW27_03445 ENOG4105BZU Histidine kinase EJW27_03495 ENOG4108RIR Molybdenum cofactor biosynthesis protein EJW27_03505 ENOG4105BZF Glycosyl transferase (Group 1 EJW27_03510 ENOG4105YVM Phosphoesterase, PA-phosphatase related EJW27_03515 ENOG4108Z0R Transferase EJW27_03520 ENOG4105E8V Alpha Beta Hydrolase Fold protein EJW27_03555 ENOG4105CIG ABC transporter EJW27_03570 ENOG4105N5T Radical SAM Protein EJW27_03590 ENOG4105D7V transposase EJW27_03610 ENOG4105C19 ABC transporter EJW27_03630 ENOG4105NCW Trka-c domain protein EJW27_03640 ENOG410605W Major Facilitator EJW27_03645 ENOG4105C8T Leucyl-tRNA synthetase EJW27_03675 ENOG4108B31 Spore germination protein EJW27_03695 ENOG41085GJ domain protein EJW27_03715 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EJW27_03720 ENOG4105D06 uba thif-type nad fad binding protein EJW27_03730 ENOG4105CVM Molybdenum cofactor synthesis domain protein EJW27_03735 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein EJW27_03740 ENOG4108ZAF Molybdopterin EJW27_03760 ENOG4107EXU Short-chain dehydrogenase reductase Sdr EJW27_03820 ENOG4105YW5 deoR family transcriptional regulator EJW27_03825 ENOG4107QSE Dipeptidase EJW27_03835 ENOG4108IUM Glycogen debranching enzyme EJW27_03840 ENOG4108V15 phosphotransferase enzyme family EJW27_03855 ENOG4105C8F Beta-lactamase domain protein EJW27_03885 ENOG4108VDD TRNA binding domain protein EJW27_03940 ENOG4105C88 aminopeptidase EJW27_04000 ENOG4105EP9 oxidoreductase EJW27_04005 ENOG4107SNB ankyrin repeat protein YahD EJW27_04015 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EJW27_04035 ENOG4105W87 Cbs domain EJW27_04040 ENOG4105F1V Acetoin utilization protein EJW27_04050 ENOG4108UW5 maltose o-acetyltransferase EJW27_04060 ENOG4105EMN RNA polymerase sigma factor EJW27_04115 ENOG4105U5Y Transcriptional regulator EJW27_04150 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJW27_04160 ENOG4105EFZ amidohydrolase EJW27_04175 ENOG4105KBJ sporulation protein ytfj EJW27_04180 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) EJW27_04190 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EJW27_04210 ENOG4108JYZ YitT family EJW27_04255 ENOG4107YZX Universal stress protein EJW27_04275 ENOG41082W1 Cupin 2, conserved barrel domain protein EJW27_04320 ENOG4105DC7 peptidase M24 EJW27_04355 ENOG4105SFS phosphoesterase RecJ domain protein EJW27_04365 ENOG4105VV2 EJW27_04375 ENOG4105C6K Malic enzyme EJW27_04380 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family EJW27_04405 ENOG4105FS0 cytoplasmic membrane protein EJW27_04410 ENOG4108REF Sporulation integral membrane protein ytvi EJW27_04425 ENOG4105BZN citrate synthase EJW27_04430 ENOG4108HMX isocitrate dehydrogenase (NADP) EJW27_04450 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EJW27_04455 ENOG4105BZU Histidine kinase EJW27_04460 ENOG4105C2M dna polymerase I EJW27_04480 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EJW27_04485 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) EJW27_04505 ENOG4108TDW sporulation protein YtxC EJW27_04510 ENOG4105C22 threonyL-tRNA synthetase EJW27_04515 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EJW27_04535 ENOG4105CN9 Peptidase m42 family protein EJW27_04540 ENOG4108JGH Tetr family transcriptional regulator EJW27_04545 ENOG4105CW7 secretion protein, HlyD family EJW27_04590 ENOG4108RWN rrna methyltransferase EJW27_04600 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EJW27_04605 ENOG4105C5S asparaginyl-tRNA synthetase EJW27_04620 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EJW27_04645 ENOG4105FE9 pseudouridine synthase EJW27_04655 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) EJW27_04665 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) EJW27_04680 ENOG4105E0A ABC, transporter EJW27_04685 ENOG4105KFN sortase, SrtB family EJW27_04695 ENOG4105DR4 Methyltransferase EJW27_04705 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EJW27_04755 ENOG4105J76 Periplasmic binding protein EJW27_04765 ENOG4105CEY Amp-dependent synthetase and ligase EJW27_04770 ENOG4107Z3H Transcriptional regulator, TetR family EJW27_04775 ENOG41060WC Enoyl-CoA hydratase EJW27_04780 ENOG4105BZJ Electron transfer flavoprotein EJW27_04785 ENOG4105C10 Electron transfer flavoprotein EJW27_04790 ENOG4105K63 Thioredoxin EJW27_04805 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit EJW27_04815 ENOG4105E33 succinate dehydrogenase EJW27_04825 ENOG4108VXD carboxy-peptidase EJW27_04830 ENOG4105E14 MotA TolQ exbB proton channel EJW27_04840 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family EJW27_04845 ENOG4108IUX (ABC) transporter EJW27_04850 ENOG4105RHA ABC transporter, permease EJW27_04855 ENOG4108Z40 Transcriptional regulator EJW27_04860 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EJW27_04870 ENOG4108JCI Transcriptional regulator EJW27_04875 ENOG41067S9 phage shock protein C, PspC EJW27_04880 ENOG4105DZC cytosine deaminase EJW27_04890 ENOG4105PFC Transcriptional regulator EJW27_04910 ENOG4105KBX Transcriptional regulator, TetR family EJW27_04930 ENOG4108XJQ germination protein EJW27_04940 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EJW27_04945 ENOG4105M59 Phosphodiesterase, mj0936 family EJW27_04965 ENOG4108QCI YvbH-like oligomerisation region EJW27_04995 ENOG4108IUQ atp-dependent protease EJW27_05015 ENOG4105K56 Transcriptional regulator EJW27_05040 ENOG4105D52 delta-aminolevulinic acid dehydratase EJW27_05050 ENOG41068KH stage VI sporulation protein D EJW27_05065 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EJW27_05090 ENOG4105DFF Rod shape-determining protein mreb EJW27_05095 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) EJW27_05110 ENOG4107QMS site-determining protein EJW27_05125 ENOG4105C03 ribonuclease EJW27_05135 ENOG4105X36 (ribosomal) protein EJW27_05150 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EJW27_05160 ENOG4105EWM Histidine kinase EJW27_05185 ENOG4108RPX mosc domain containing protein EJW27_05200 ENOG4108IYU L-aspartate oxidase EJW27_05205 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EJW27_05235 ENOG4108HUF Transporter EJW27_05250 ENOG41061AI Protein of unknown function (DUF2905) EJW27_05265 ENOG4105VIE preprotein translocase, subunit YajC EJW27_05275 ENOG4108QG2 Membrane EJW27_05280 ENOG4105CKP Polysaccharide Biosynthesis Protein EJW27_05295 ENOG41076HS cation diffusion facilitator family transporter EJW27_05300 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EJW27_05310 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EJW27_05330 ENOG4105CUT histidyl-tRNA synthetase EJW27_05340 ENOG4105CUZ uba thif-type nad fad binding protein EJW27_05350 ENOG4108VCI transcription factor, rsfa family EJW27_05355 ENOG4105D1H recombination factor protein RarA EJW27_05365 ENOG4105C3J Cysteine desulfurase EJW27_05380 ENOG4105C7H Helicase, RecD TraA family EJW27_05385 ENOG41060CR EJW27_05400 ENOG4105C02 permease EJW27_05430 ENOG4105HHA aminodeoxychorismate lyase EJW27_05435 ENOG4108VQJ O-methyltransferase EJW27_05440 ENOG4105XYU peptidase (U32 family) EJW27_05445 ENOG4105CFP Peptidase U32 EJW27_05490 ENOG4105C28 cystathionine EJW27_05495 ENOG4108EKI Dehydrogenase EJW27_05510 ENOG4108V5C ABC transporter EJW27_05515 ENOG4105S6R Iron-hydroxamate transporter permease subunit EJW27_05555 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EJW27_05565 ENOG4105MIR Phenylalanine 4-monooxygenase EJW27_05570 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin EJW27_05605 ENOG4108MUZ hydrolase EJW27_05615 ENOG4105G6Z alkaline phosphatase EJW27_05645 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJW27_05660 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase EJW27_05665 ENOG4105CQW ribosome biogenesis GTPase YqeH EJW27_05675 ENOG410812S Rna-binding protein EJW27_05685 ENOG4108WF2 Metal Dependent Phosphohydrolase EJW27_05705 ENOG4105KQC Competence protein EJW27_05710 ENOG4108UK2 deaminase EJW27_05715 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EJW27_05725 ENOG4105TQK DNA polymerase iii, delta' subunit EJW27_05750 ENOG4105KVH Transcriptional regulator EJW27_05755 ENOG4105CSA Coproporphyrinogen iii oxidase EJW27_05765 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EJW27_05785 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EJW27_05790 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EJW27_05805 ENOG4105KTH gatB Yqey EJW27_05810 ENOG41068P3 sporulation protein YqfC EJW27_05825 ENOG4105CTJ Metal Dependent Phosphohydrolase EJW27_05835 ENOG4107YR5 Diacylglycerol kinase EJW27_05840 ENOG4105KG3 cytidine deaminase EJW27_05845 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EJW27_05870 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EJW27_05875 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJW27_05890 ENOG4105EGD dinuclear metal center protein, YbgI family EJW27_05915 ENOG41069ZM Protein of unknown function (DUF2624) EJW27_05920 ENOG4108JYZ YitT family EJW27_05925 ENOG4105FDK ABC transporter EJW27_05935 ENOG4105N80 Ferric uptake regulator, Fur family EJW27_05960 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EJW27_05970 ENOG4107RF6 penicillin-binding protein EJW27_05975 ENOG4105PWN phosphate abc transporter EJW27_05980 ENOG4105C8U phosphate abc transporter EJW27_05985 ENOG4105E2Z phosphate ABC transporter (Permease EJW27_05990 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EJW27_05995 ENOG4108UTW Plays a role in the regulation of phosphate uptake EJW27_06010 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EJW27_06020 ENOG4105DKQ ROK family EJW27_06030 ENOG4105C5X domain protein EJW27_06050 ENOG4105C28 cystathionine EJW27_06055 ENOG4105C28 cystathionine EJW27_06065 ENOG4105C3R Methionine synthase EJW27_06185 ENOG4105C0D helicase EJW27_06220 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EJW27_06225 ENOG4105CJ1 ABC, transporter EJW27_06260 ENOG41080TC multidrug resistance protein EJW27_06285 ENOG4105WZW rhodanese family EJW27_06290 ENOG41082GG biotin lipoate A B protein ligase EJW27_06320 ENOG4107YBY Hydrolase EJW27_06330 ENOG4105CBJ Metal-dependent enzyme EJW27_06345 ENOG4105DC7 peptidase M24 EJW27_06365 ENOG4105CD2 stage iii sporulation protein aa EJW27_06370 ENOG4105KR5 Stage iii sporulation protein EJW27_06375 ENOG4108CQH stage III sporulation protein AC EJW27_06380 ENOG4105KQ4 Stage iii sporulation protein ad EJW27_06390 ENOG410644B Stage III sporulation protein af EJW27_06415 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EJW27_06420 ENOG4108ZSR alkaline shock protein EJW27_06445 ENOG4105CTB Polyprenyl synthetase EJW27_06455 ENOG4105DX0 Hemolysin A EJW27_06465 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EJW27_06470 ENOG4105S1Z Stage IV sporulation protein B EJW27_06480 ENOG4107QQR Sporulation EJW27_06495 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EJW27_06505 ENOG4108JUB Transcriptional regulator EJW27_06520 ENOG4107RDP Dehydrogenase EJW27_06540 ENOG4105CPP Dehydrogenase, E1 component EJW27_06570 ENOG4108HW3 (ABC) transporter EJW27_06575 ENOG4105E5Q amino acid AbC transporter EJW27_06580 ENOG4105CDA abc transporter atp-binding protein EJW27_06585 ENOG4108QEG Membrane EJW27_06590 ENOG4108VZI ErfK ybiS ycfS ynhG family protein EJW27_06600 ENOG4105D9U N-acetyltransferase EJW27_06605 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EJW27_06615 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EJW27_06640 ENOG4105EJQ L-serine dehydratase EJW27_06645 ENOG4105II7 pyrroline-5-carboxylate reductase EJW27_06650 ENOG41069FQ Metallo-beta-lactamase superfamily EJW27_06655 ENOG4108IXY short-chain dehydrogenase reductase EJW27_06670 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) EJW27_06675 ENOG4105CAS nag kinase EJW27_06720 ENOG4105CGH 5'-nucleotidase EJW27_06725 ENOG4105DFD Na H antiporter EJW27_06735 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EJW27_06750 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EJW27_06755 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EJW27_06780 ENOG4108R6K riboflavin synthase, subunit alpha EJW27_06785 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EJW27_06805 ENOG4108YM7 Gcn5-related n-acetyltransferase EJW27_06840 ENOG4105RHY Pfam:UPF0157 EJW27_06870 ENOG4105MZ9 stage II sporulation protein m EJW27_06875 ENOG4105I3K Ferric uptake regulator, Fur family EJW27_06885 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EJW27_06910 ENOG4105D7N magnesium and cobalt transport protein CorA EJW27_06945 ENOG4105DVE abc transporter atp-binding protein EJW27_06950 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EJW27_06960 ENOG4105DZ1 carboxypeptidase EJW27_06965 ENOG41082AN stage II sporulation protein EJW27_06975 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJW27_06980 ENOG4105C8J )-transporter EJW27_07000 ENOG41090VF Stage v sporulation protein ac EJW27_07005 ENOG4105CZ3 stage V sporulation protein ad EJW27_07025 ENOG4105J7I hydrolase EJW27_07030 ENOG4105PTM secreted protein EJW27_07035 ENOG4107ZE5 PPIases accelerate the folding of proteins EJW27_07075 ENOG4108EC8 DNA internalization-related competence protein ComEC EJW27_07080 ENOG4105CE4 GlcNAc 6-P deacetylase EJW27_07090 ENOG4105FDP GntR family transcriptional regulator EJW27_07100 ENOG4105CID antiterminator EJW27_07115 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EJW27_07135 ENOG4105BZU Histidine kinase EJW27_07145 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EJW27_07160 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) EJW27_07185 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EJW27_07205 ENOG4105DTD Dehydrogenase EJW27_07210 ENOG4105K7K Transcriptional regulator EJW27_07245 ENOG4105CHU acetyl-coa acetyltransferase EJW27_07250 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EJW27_07290 ENOG4105CG3 alpha amylase, catalytic region EJW27_07300 ENOG4107FKK extracellular solute-binding protein family 1 EJW27_07310 ENOG4105EG2 ABC transporter, permease EJW27_07315 ENOG4105FKQ transcriptional regulator EJW27_07320 ENOG4105CHM Aminotransferase EJW27_07330 ENOG4108HGU Histidine kinase EJW27_07370 ENOG4105D7V transposase EJW27_07405 ENOG4105UIN EJW27_07430 ENOG4105K6S Short-chain dehydrogenase reductase Sdr EJW27_07435 ENOG4105EPM Diguanylate phosphodiesterase EJW27_07450 ENOG4107IN1 Protein of unknown function (DUF1797) EJW27_07455 ENOG4108XRC Protein of unknown function (DUF458) EJW27_07490 ENOG4107ZYR domain protein EJW27_07495 ENOG4105CN5 Metallo-Beta-Lactamase EJW27_07510 ENOG4108X4Q Hydrolase EJW27_07515 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EJW27_07530 ENOG4105CPP Dehydrogenase, E1 component EJW27_07580 ENOG4105CXN decarboxylase EJW27_07600 ENOG4105ECY inositol monophosphatase EJW27_07610 ENOG4105CI3 gtp-binding protein typa EJW27_07615 ENOG4105QA2 EJW27_07635 ENOG4108IAB Phoh family EJW27_07650 ENOG4105CNI cell division protein FtsW EJW27_07660 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) EJW27_07705 ENOG4106UY4 Inherit from COG: Scp-like extracellular EJW27_07720 ENOG4107TB6 phosphoglycerate mutase EJW27_07740 ENOG4106H78 methyltransferase EJW27_07750 ENOG4105H20 Sporulation integral membrane protein YlbJ EJW27_07755 ENOG4105D78 K07001 NTE family protein EJW27_07760 ENOG41063PX domain protein EJW27_07770 ENOG4105KNH Nucleic acid-binding protein EJW27_07805 ENOG41068DC Essential cell division protein (By similarity) EJW27_07810 ENOG4105CJN penicillin-binding protein EJW27_07815 ENOG4105CJN penicillin-binding protein EJW27_07820 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EJW27_07835 ENOG4105CNI cell division protein FtsW EJW27_07840 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EJW27_07850 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) EJW27_07855 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EJW27_07860 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EJW27_07870 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJW27_07880 ENOG4105WR5 sporulation protein, YlmC YmxH family EJW27_07885 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EJW27_07890 ENOG4105DFA alanine racemase domain protein EJW27_07900 ENOG41067XK integral membrane protein EJW27_07905 ENOG4105DBK s4 domain protein EJW27_07930 ENOG4105C34 Pseudouridine synthase EJW27_07965 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) EJW27_08015 ENOG4105F23 Fibronectin-binding protein EJW27_08025 ENOG4105DSJ YicC domain protein EJW27_08045 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EJW27_08065 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EJW27_08075 ENOG4108ZF3 Phosphatase EJW27_08080 ENOG4105D9P serine threonine protein kinase EJW27_08090 ENOG4105DJV ribulose-phosphate 3-epimerase EJW27_08095 ENOG4105FJ0 thiamine EJW27_08110 ENOG4108ZAA Alkaline-shock protein EJW27_08115 ENOG4105DP4 dak2 domain fusion protein ylov EJW27_08135 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EJW27_08140 ENOG4105CHR reductase EJW27_08160 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EJW27_08180 ENOG4105VB6 UPF0109 protein EJW27_08205 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) EJW27_08220 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EJW27_08225 ENOG4105C79 DNA protecting protein DprA EJW27_08230 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EJW27_08285 ENOG4105KNE Phosphatidate cytidylyltransferase EJW27_08290 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EJW27_08295 ENOG4105DZP Membrane-associated zinc metalloprotease EJW27_08315 ENOG4105CHV Transcription elongation factor NusA EJW27_08320 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination EJW27_08325 ENOG4105VHM ribosomal protein EJW27_08335 ENOG4105W7A Protein of unknown function (DUF503) EJW27_08345 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EJW27_08350 ENOG4105DTN riboflavin biosynthesis protein ribF EJW27_08370 ENOG4105C1V Peptidase, M16 EJW27_08380 ENOG4105E35 Dipicolinate synthase subunit A EJW27_08385 ENOG4108S0H Dipicolinic acid synthetase, b subunit EJW27_08400 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EJW27_08410 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit EJW27_08420 ENOG4107QZI cell division protein FtsK EJW27_08435 ENOG4105DIH basic membrane EJW27_08440 ENOG4108JQ9 ABC transporter EJW27_08445 ENOG4105UIB (ABC) transporter EJW27_08465 ENOG4108RKS Short-chain dehydrogenase reductase Sdr EJW27_08470 ENOG4105XZV Protein of unknown function (DUF3243) EJW27_08485 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EJW27_08505 ENOG4105D48 metallophosphoesterase EJW27_08510 ENOG4105MCT stage V sporulation protein S EJW27_08515 ENOG4108IGT Dipeptidase EJW27_08520 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein EJW27_08525 ENOG4105DQU oxidoreductase, subunit beta EJW27_08560 ENOG4107QHE Choloylglycine hydrolase EJW27_08570 ENOG410890F Dynamin family EJW27_08575 ENOG4105E0M Sulfatase EJW27_08590 ENOG4105F0V Cell wall hydrolase EJW27_08605 ENOG4105CS2 ec 3.2.1.21 EJW27_08610 ENOG4108S3Y transcriptional regulator EJW27_08620 ENOG4107YEI lmbE family EJW27_08625 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EJW27_08640 ENOG41067MG lrgb family EJW27_08695 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase EJW27_08725 ENOG4105D03 DNA-3-methyladenine glycosylase II EJW27_08730 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EJW27_08740 ENOG4105CGK Exodeoxyribonuclease III EJW27_08760 ENOG4105E0A ABC, transporter EJW27_08765 ENOG4105NIV Esterase EJW27_08775 ENOG4105VPX protein, conserved in bacteria EJW27_08780 ENOG410681U heavy metal transport detoxification protein EJW27_08785 ENOG4105C59 p-type ATPase EJW27_08795 ENOG4105K70 DNA-binding protein EJW27_08820 ENOG4105C85 amino acid EJW27_08830 ENOG4108SJC Membrane EJW27_08835 ENOG4107QW4 alcohol dehydrogenase EJW27_08840 ENOG4105E98 transcriptional regulator DeoR family EJW27_08845 ENOG4105DE4 1-phosphofructokinase EJW27_08850 ENOG4105DM4 PTS System EJW27_08855 ENOG41069ER domain protein EJW27_08895 ENOG4106F1P AAA ATPase, central domain protein EJW27_08905 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EJW27_08910 ENOG4105CXI aluminum resistance protein EJW27_08915 ENOG4105KV4 Transcriptional regulator EJW27_08925 ENOG4105DQ6 Transposase EJW27_08930 ENOG4105K7K Transcriptional regulator EJW27_08950 ENOG4108SVB resolvase EJW27_08960 ENOG4105CGH 5'-nucleotidase EJW27_08965 ENOG4108HW3 (ABC) transporter EJW27_09005 ENOG4105BZ1 (ABC) transporter EJW27_09010 ENOG4105BZ1 (ABC) transporter EJW27_09035 ENOG41067MG lrgb family EJW27_09045 ENOG4107RSM transcriptional regulator EJW27_09060 ENOG4105CJ1 ABC, transporter EJW27_09070 ENOG4105CH2 amidohydrolase EJW27_09085 ENOG4107QIV Cytochrome c biogenesis protein EJW27_09120 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) EJW27_09145 ENOG4108903 Formimidoylglutamase EJW27_09150 ENOG4108VJ1 Transcriptional regulator (CarD family EJW27_09155 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EJW27_09160 ENOG4105CBC glutamate synthase EJW27_09165 ENOG4105CK7 Sodium proline symporter EJW27_09170 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase EJW27_09175 ENOG4105FBA Phospholipase Carboxylesterase EJW27_09180 ENOG4105BZU Histidine kinase EJW27_09235 ENOG4105CEY Amp-dependent synthetase and ligase EJW27_09240 ENOG4107ZYJ bioY protein EJW27_09245 ENOG4107F3J Amp-dependent synthetase and ligase EJW27_09310 ENOG4105BZ1 (ABC) transporter EJW27_09330 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EJW27_09335 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) EJW27_09360 ENOG4105D7V transposase EJW27_09370 ENOG4105W8X HesB YadR YfhF-family protein EJW27_09380 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase EJW27_09385 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) EJW27_09390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJW27_09395 ENOG4105C0H protease EJW27_09400 ENOG4105K4P CoA-binding domain protein EJW27_09405 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJW27_09415 ENOG4105D9R oxidoreductase EJW27_09425 ENOG4105CIG ABC transporter EJW27_09440 ENOG4105EMN RNA polymerase sigma factor EJW27_09450 ENOG4108KGH TRANSCRIPTIONal EJW27_09455 ENOG4107QJT sodium dicarboxylate symporter EJW27_09510 ENOG4105CUB amino acid EJW27_09525 ENOG4105E1K spore germination protein EJW27_09530 ENOG4108JB9 formate dehydrogenase EJW27_09540 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) EJW27_09545 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EJW27_09555 ENOG4105TMB Formate nitrite transporter EJW27_09565 ENOG4105CVM Molybdenum cofactor synthesis domain protein EJW27_09570 ENOG4108ZAF Molybdopterin EJW27_09595 ENOG410696E Membrane EJW27_09600 ENOG4105FR1 rard protein EJW27_09610 ENOG4105EWU Squalene--hopene cyclase EJW27_09620 ENOG4105CHR reductase EJW27_09625 ENOG4105C26 Dehydrogenase EJW27_09635 ENOG4108IA2 Sodium pantothenate symporter EJW27_09650 ENOG4106IQC argininosuccinate lyase EJW27_09660 ENOG410904N short-chain dehydrogenase reductase EJW27_09680 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EJW27_09700 ENOG4105VEQ Cold shock protein EJW27_09715 ENOG4108R1P EJW27_09725 ENOG41073R8 VanW family EJW27_09730 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EJW27_09775 ENOG4106UK0 Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity EJW27_09780 ENOG41067SE Tetr family transcriptional regulator EJW27_09790 ENOG4105BZU Histidine kinase EJW27_09805 ENOG4105CQB FAD linked oxidase domain protein EJW27_09810 ENOG4105C09 Bile acid EJW27_09840 ENOG4105CIS alcohol dehydrogenase EJW27_09845 ENOG41082BM Transcriptional regulator, arsr family EJW27_09855 ENOG4107VXM glycerophosphoryl diester phosphodiesterase EJW27_09880 ENOG4108A04 Beta-lactamase EJW27_09885 ENOG4105DWY Agmatine deiminase EJW27_09895 ENOG4105FFC UPF0187 protein EJW27_09910 ENOG4105D7V transposase EJW27_09930 ENOG4105DPN Oligoendopeptidase f EJW27_09935 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase EJW27_09955 ENOG4105C98 muts2 protein EJW27_09985 ENOG4107V2S Transcriptional regulator EJW27_09995 ENOG4107CUJ Protein of unknown function (DUF2690) EJW27_10025 ENOG4105DQ5 transport system permease protein EJW27_10030 ENOG4105EHG Permease protein EJW27_10035 ENOG4108MES Periplasmic binding protein EJW27_10050 ENOG4107R3E Citrate transporter EJW27_10060 ENOG4108TN2 lmbE family EJW27_10085 ENOG4105CIS alcohol dehydrogenase EJW27_10120 ENOG4105H3G oxidoreductase EJW27_10155 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) EJW27_10240 ENOG4105KVH Transcriptional regulator EJW27_10245 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein EJW27_10260 ENOG4108RU0 short-chain dehydrogenase reductase EJW27_10270 ENOG4105JAB phenazine biosynthesis protein, phzf family EJW27_10325 ENOG4105C44 Serine transporter EJW27_10340 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EJW27_10350 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EJW27_10355 ENOG4105CMG Carbohydrate kinase EJW27_10360 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) EJW27_10365 ENOG4105XDF Protein of unknown function (DUF1272) EJW27_10400 ENOG4105FAW cDP-glucose 4,6-dehydratase EJW27_10405 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase EJW27_10420 ENOG4105C37 (CBS) domain EJW27_10445 ENOG4105EV4 Multidrug resistance protein mdtH EJW27_10455 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) EJW27_10480 ENOG4105C31 Tryptophanyl-tRNA synthetase EJW27_10555 ENOG4108PSK reductase EJW27_10575 ENOG4108RCM Nitroreductase EJW27_10580 ENOG4105KVH Transcriptional regulator EJW27_10590 ENOG4108Z66 YbaK ebsC protein EJW27_10620 ENOG4108K8S endonuclease I EJW27_10645 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) EJW27_10680 ENOG4105DYS nad(p)h dehydrogenase (quinone) EJW27_10690 ENOG4105CRW Short chain fatty acid transporter EJW27_10710 ENOG4107AUC EJW27_10715 ENOG4105KBX Transcriptional regulator, TetR family EJW27_10720 ENOG4105KPY Small multidrug resistance protein EJW27_10725 ENOG4105RXJ EJW27_10735 ENOG41069JR EJW27_10740 ENOG4105DA5 (ABC) transporter EJW27_10755 ENOG4105CZM Major Facilitator EJW27_10760 ENOG4107MII Sugar-specific transcriptional regulator TrmB EJW27_11075 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EJW27_11095 ENOG410874W AraC family transcriptional regulator EJW27_11105 ENOG41082W1 Cupin 2, conserved barrel domain protein EJW27_11125 ENOG4108JQ1 Dehydrogenase EJW27_11140 ENOG4105DVH amino acid EJW27_11165 ENOG4108JPW Aminotransferase EJW27_11180 ENOG4105EJQ L-serine dehydratase EJW27_11185 ENOG4105C44 Serine transporter EJW27_11200 ENOG4108JGH Tetr family transcriptional regulator EJW27_11205 ENOG4105EQ0 Major Facilitator superfamily EJW27_11260 ENOG4107TSN permease EJW27_11275 ENOG4108KU9 integrase family EJW27_11280 ENOG4108FPN Integrase EJW27_11325 ENOG4105TRI Hydrolase EJW27_11390 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EJW27_11400 ENOG4105BZU Histidine kinase EJW27_11420 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) EJW27_11445 ENOG4105JQZ Methyltransferase EJW27_11465 ENOG4105K6H D-cysteine desulfhydrase EJW27_11500 ENOG41062D9 Histidine kinase EJW27_11505 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJW27_11600 ENOG4105N0V mono-oxygenase ydhR EJW27_11640 ENOG4108YXU transcriptional regulator AsnC family EJW27_11645 ENOG4105CHR reductase EJW27_11650 ENOG4108IG5 Transcriptional regulator EJW27_11655 ENOG4107P5I polyketide synthase EJW27_11720 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase EJW27_11725 ENOG4105D6J arsenicaL-resistance protein EJW27_11750 ENOG4105DIK (ABC) transporter EJW27_11755 ENOG4105CC5 ABC transporter EJW27_11760 ENOG4105DSE periplasmic solute binding protein EJW27_11780 ENOG4105C19 ABC transporter EJW27_11800 ENOG4105E5W Transporter EJW27_11820 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EJW27_11835 ENOG4105GPN Uncharacterized conserved protein (DUF2294) EJW27_11840 ENOG4108TWJ NADH dehydrogenase subunit 5 EJW27_11860 ENOG4108606 TspO/MBR family EJW27_11960 ENOG4105CHJ isochorismatase hydrolase EJW27_12030 ENOG4108Q8B Spore germination protein EJW27_12070 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EJW27_12090 ENOG41075H3 AraC family transcriptional regulator EJW27_12115 ENOG4105BZU Histidine kinase EJW27_12125 ENOG4108B31 Spore germination protein EJW27_12140 ENOG4108TVJ Nitroreductase EJW27_12145 ENOG4108IMY Transcriptional regulator EJW27_12150 ENOG4105HDK L-asparaginase EJW27_12155 ENOG4108IJ0 Aspartate ammonia-lyase EJW27_12170 ENOG4105E2A Dehydrogenase EJW27_12235 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EJW27_12270 ENOG4105DWD nucleoside recognition domain protein EJW27_12285 ENOG4105FDT acyl-CoA dehydrogenase EJW27_12295 ENOG4108ZHR arsR family transcriptional regulator EJW27_12320 ENOG4107258 Transcriptional regulator EJW27_12325 ENOG4105P4J Allophanate hydrolase, subunit 1 EJW27_12355 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EJW27_12360 ENOG4107RF6 penicillin-binding protein EJW27_12380 ENOG4107ZY0 Phenazine biosynthesis-like protein EJW27_12395 ENOG4105F1N DNA alkylation repair EJW27_12405 ENOG4108IQI permease EJW27_12415 ENOG410635A Membrane EJW27_12440 ENOG4105RHY Pfam:UPF0157 EJW27_12470 ENOG4107XJU UPF0178 protein EJW27_12480 ENOG4108PCN EamA-like transporter family EJW27_12495 ENOG4108XET gCN5-related N-acetyltransferase EJW27_12500 ENOG4108DMH HTH_ARAC EJW27_12510 ENOG4105CMR udp-glucose 4-epimerase EJW27_12520 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EJW27_12560 ENOG4105FS7 Transcriptional regulator EJW27_12565 ENOG4108TVJ Nitroreductase EJW27_12615 ENOG41090AA EJW27_12720 ENOG4105CKK Glycosyl transferase, family 2 EJW27_12745 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EJW27_12770 ENOG41068WN EJW27_12785 ENOG4108WCX response regulator EJW27_12795 ENOG41090T1 Membrane EJW27_12820 ENOG4105E98 transcriptional regulator DeoR family EJW27_12825 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EJW27_12860 ENOG4105ECK Fatty Acid Desaturase EJW27_12865 ENOG4105E0Y RtcB Protein EJW27_12880 ENOG4107258 Transcriptional regulator EJW27_12890 ENOG4105II7 pyrroline-5-carboxylate reductase EJW27_12920 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) EJW27_12960 ENOG4105DKT Transcriptional regulator EJW27_12965 ENOG4105C2J ABC transporter EJW27_12970 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane EJW27_12980 ENOG4105D4B ABC, transporter EJW27_13000 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase EJW27_13015 ENOG41069ER domain protein EJW27_13045 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EJW27_13075 ENOG41082JN Transcriptional regulator EJW27_13090 ENOG4105C5H ABC transporter EJW27_13110 ENOG4107VMI polysaccharide deacetylase EJW27_13125 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase EJW27_13130 ENOG4105C6T cysteine synthase EJW27_13150 ENOG4105I4A GCN5-related N-acetyltransferase EJW27_13185 ENOG4108AQF aminoglycoside N(3)-acetyltransferase EJW27_13205 ENOG4105E09 nadh pyrophosphatase EJW27_13220 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein EJW27_13225 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EJW27_13280 ENOG4108ZMI UPF0477 protein EJW27_13295 ENOG4105CHM Aminotransferase EJW27_13330 ENOG41089UC methyltransferase, type 11 EJW27_13345 ENOG4107BMA Transglycosylase associated protein EJW27_13430 ENOG4105EPR degv family EJW27_13450 ENOG4105DVH amino acid EJW27_13455 ENOG4105DPN Oligoendopeptidase f EJW27_13500 ENOG4105BZU Histidine kinase EJW27_13505 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) EJW27_13560 ENOG4105DTQ mandelate racemase muconate lactonizing EJW27_13585 ENOG4107T5V SNARE associated Golgi EJW27_13590 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EJW27_13620 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein EJW27_13630 ENOG41080HI glycine oxidase EJW27_13635 ENOG4105CTU Proline racemase EJW27_13640 ENOG4105CTU Proline racemase EJW27_13645 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EJW27_13650 ENOG4105C26 Dehydrogenase EJW27_13655 ENOG4105BZG amino acid carrier protein EJW27_13680 ENOG4108M1A Chitin-binding protein EJW27_13760 ENOG4107Y9U Membrane EJW27_13795 ENOG4105FCD Major Facilitator EJW27_13815 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EJW27_13820 ENOG4108Z4K mutator MutT protein EJW27_13840 ENOG4107TB6 phosphoglycerate mutase EJW27_13845 ENOG4108XI2 Domain of unknown function (DUF1963) EJW27_13875 ENOG4105KWG Pfam:DUF1696 EJW27_13910 ENOG4105PKS Excinuclease abc c subunit domain protein EJW27_13935 ENOG4108JW7 Maf-like protein EJW27_13940 ENOG4107VFR oxidoreductase EJW27_13965 ENOG4105PAD Hydrolase EJW27_14005 ENOG4105DY8 decarboxylase EJW27_14045 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EJW27_14050 ENOG4105FDR Membrane EJW27_14110 ENOG4105MSI germination protein ypeb EJW27_14140 ENOG4107VWA Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity) EJW27_14165 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EJW27_14180 ENOG4105E98 transcriptional regulator DeoR family EJW27_14200 ENOG4107QKR Dehydrogenase EJW27_14210 ENOG4107RUY (E1 component), alpha subunit EJW27_14220 ENOG4105E1F short-chain dehydrogenase reductase EJW27_14225 ENOG4105RHY Pfam:UPF0157 EJW27_14295 ENOG41082BV acetyltransferase EJW27_14300 ENOG4108M1A Chitin-binding protein EJW27_14325 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EJW27_14330 ENOG4105MSB protein, conserved in bacteria EJW27_14380 ENOG4105EEM helicase EJW27_14410 ENOG4105C9U ATP-dependent DNA helicase RecQ EJW27_14470 ENOG4105FQP Beta-lactamase EJW27_14480 ENOG4105CJN penicillin-binding protein EJW27_14485 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EJW27_14490 ENOG4105CB2 alcohol dehydrogenase EJW27_14505 ENOG4108HGU Histidine kinase EJW27_14550 ENOG410667J hydrolase EJW27_14690 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EJW27_14710 ENOG4105VZ8 Transcriptional regulator EJW27_14720 ENOG4106ANW SMI1_KNR4 EJW27_14765 ENOG4105ETU transcriptional activator (TenA EJW27_14780 ENOG4105D6E homoserine dehydrogenase EJW27_14860 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein EJW27_14870 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EJW27_14925 ENOG4105CUV Homoserine Kinase EJW27_14940 ENOG41089UC methyltransferase, type 11 EJW27_14960 ENOG4108V4B ThiJ pfpI EJW27_15005 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EJW27_15035 ENOG41075H3 AraC family transcriptional regulator EJW27_15055 ENOG4108RYK Nad-dependent epimerase dehydratase EJW27_15060 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EJW27_15075 ENOG4105T9C HD domain EJW27_15105 ENOG4105DBI uridine monophosphokinase EJW27_15130 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EJW27_15135 ENOG4107QX3 carboxylase EJW27_15140 ENOG4105E39 Enoyl-CoA hydratase EJW27_15145 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EJW27_15150 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit EJW27_15155 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EJW27_15175 ENOG4107Z3H Transcriptional regulator, TetR family EJW27_15195 ENOG4107RGJ metallophosphoesterase EJW27_15255 ENOG4105CIN aminoacyl-histidine dipeptidase EJW27_15300 ENOG41088CC tellurite resistance protein tehB EJW27_15320 ENOG4105C1J atp-dependent rna helicase EJW27_15370 ENOG4105RD7 BadF BadG BcrA BcrD EJW27_15395 ENOG4105F32 YngK protein EJW27_15415 ENOG4108KPJ rna polymerase sigma factor EJW27_15470 ENOG4108JCI Transcriptional regulator EJW27_15490 ENOG4105BZ1 (ABC) transporter EJW27_15495 ENOG4105BZ1 (ABC) transporter EJW27_15510 ENOG4108RPX mosc domain containing protein EJW27_15515 ENOG4105DND Transcriptional regulator EJW27_15535 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EJW27_15540 ENOG4107V2S Transcriptional regulator EJW27_15630 ENOG4105VEQ Cold shock protein EJW27_15715 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EJW27_15725 ENOG4105D7V transposase EJW27_15735 ENOG4107RCM Releases the N-terminal proline from various substrates (By similarity) EJW27_15745 ENOG4108Y4K DNA-binding transcriptional activator EJW27_15780 ENOG4108D32 Methyltransferase EJW27_15805 ENOG4107SKW Inherit from COG: Alpha beta hydrolase EJW27_15815 ENOG4105C19 ABC transporter EJW27_15820 ENOG4105C22 threonyL-tRNA synthetase EJW27_15825 ENOG4105FE9 pseudouridine synthase EJW27_15845 ENOG4105BZG amino acid carrier protein EJW27_15865 ENOG4105K70 DNA-binding protein EJW27_15900 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EJW27_15905 ENOG4105E4F Isochorismate synthase EJW27_15910 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EJW27_15920 ENOG4105FCD Major Facilitator EJW27_15940 ENOG4107RFY SbcCD D subunit EJW27_15955 ENOG4105E39 Enoyl-CoA hydratase EJW27_15960 ENOG4105N14 lysine exporter protein LysE YggA EJW27_15970 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EJW27_15975 ENOG4105C1G acyl-Coa dehydrogenase EJW27_15980 ENOG4105CR4 methylisocitrate lyase EJW27_15985 ENOG4105DXD 2-methylcitrate dehydratase EJW27_16000 ENOG4105CZM Major Facilitator EJW27_16015 ENOG4105BZ4 penicillin-binding protein EJW27_16160 ENOG4105SZ6 Thioredoxin EJW27_16170 ENOG410841Q phosphoesterase PA-phosphatase related protein EJW27_16175 ENOG4108N23 SpoOM-related protein EJW27_16215 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EJW27_16220 ENOG4108JUB Transcriptional regulator EJW27_16225 ENOG4108TSC N-acetyltransferase EJW27_16305 ENOG4105E90 ABC transporter EJW27_16310 ENOG4108IJ8 ABC transporter EJW27_16345 ENOG4108YV3 Protein of unknown function (DUF2711) EJW27_16355 ENOG4105C6Z Gluconate EJW27_16360 ENOG4105CMG Carbohydrate kinase EJW27_16380 ENOG4106KNT transcriptional regulator EJW27_16385 ENOG4105WH1 Two component transcriptional regulator luxr family EJW27_16390 ENOG4105BZU Histidine kinase EJW27_16395 ENOG4105D8X mechanosensitive ion channel EJW27_16430 ENOG4108MES Periplasmic binding protein EJW27_16445 ENOG4105CAQ asparagine synthetase EJW27_16450 ENOG4107Y70 Heat shock protein EJW27_16455 ENOG4108KF3 Electron transport protein SCO1 SenC EJW27_16460 ENOG4105E8R UPF0173 metal-dependent hydrolase EJW27_16465 ENOG4108RCR degv family EJW27_16475 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EJW27_16485 ENOG4108UT2 hemolysin iii EJW27_16490 ENOG4105E9Q Acyl-transferase EJW27_16500 ENOG4107RVG penicillin-binding protein EJW27_16540 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 EJW27_16565 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase EJW27_16570 ENOG4105KD7 acetyltransferase EJW27_16590 ENOG4105CY2 Citrate transporter EJW27_16630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJW27_16635 ENOG4107QPK )-transporter EJW27_16640 ENOG4105BZW Glycerate kinase EJW27_16645 ENOG4105C5S asparaginyl-tRNA synthetase EJW27_16685 ENOG4105C75 arginyL-tRNA synthetase EJW27_16690 ENOG4107YX5 Pfam:DUF548 EJW27_16780 ENOG4105C5H ABC transporter EJW27_16795 ENOG4105MCT stage V sporulation protein S EJW27_16825 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) EJW27_16835 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit EJW27_16845 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein EJW27_16870 ENOG4108ZAF Molybdopterin EJW27_16875 ENOG4105CVM Molybdenum cofactor synthesis domain protein EJW27_16880 ENOG4105D06 uba thif-type nad fad binding protein EJW27_16890 ENOG4107V6Q Cyclic nucleotide-binding domain EJW27_16900 ENOG4105R3A Nitrate reductase EJW27_16905 ENOG4108IUE nitrate reductase beta subunit EJW27_16925 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EJW27_16940 ENOG4108V06 Glutathione peroxidase EJW27_16950 ENOG4105CNW domain protein EJW27_16965 ENOG4105EMN RNA polymerase sigma factor EJW27_16970 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EJW27_16980 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily EJW27_17005 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJW27_17030 ENOG4105KBJ sporulation protein ytfj EJW27_17115 ENOG4108MGT Required for secretion of EsxA and EsxB EJW27_17120 ENOG4106GSS Seems to regulate secreted factors that contribute to the establishment of persistent infections in the host. Negative regulator of EsaC, which is a secretion substrate of the Ess pathway in many Staphylococcus strains. Not necessary for the production and secretion of EsxA or EsxB (By similarity) EJW27_17150 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EJW27_17175 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJW27_17180 ENOG4108JYZ YitT family EJW27_17185 ENOG41087PP glycosyltransferase MGT family EJW27_17200 ENOG4107UWY Methyltransferase EJW27_17205 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EJW27_17215 ENOG4108X4Q Hydrolase EJW27_17240 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EJW27_17245 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) EJW27_17250 ENOG4108VXD carboxy-peptidase EJW27_17260 ENOG4108ZRV stage ii sporulation protein p EJW27_17280 ENOG4108Z7R Chaperone CsaA EJW27_17305 ENOG4105SXS Protein of unknown function (DUF456) EJW27_17335 ENOG4108S4H thioesterase Superfamily protein EJW27_17360 ENOG4107T5V SNARE associated Golgi EJW27_17380 ENOG4107TB6 phosphoglycerate mutase EJW27_17415 ENOG4105K4T epimerase EJW27_17420 ENOG4105DSE periplasmic solute binding protein EJW27_17450 ENOG4105WH1 Two component transcriptional regulator luxr family EJW27_17510 ENOG4105CKI cobalamin synthesis protein EJW27_17515 ENOG4107QM2 Aldo Keto reductase EJW27_17520 ENOG4105VMI -acetyltransferase EJW27_17535 ENOG4105DEN Luciferase family EJW27_17550 ENOG4108WPJ Ferritin-like domain EJW27_17570 ENOG4105C8Q Methyl-accepting chemotaxis EJW27_17615 ENOG4105YVS arsR family transcriptional regulator EJW27_17625 ENOG4105KRN Transcriptional regulator, abrb family EJW27_17685 ENOG4108ZUB Lysine exporter protein (Lyse ygga) EJW27_17695 ENOG4105YWU small acid-soluble spore protein EJW27_17700 ENOG4108WBH protein TIM barrel EJW27_17715 ENOG4105CEY Amp-dependent synthetase and ligase EJW27_17720 ENOG4105DUU IucA IucC family protein EJW27_17730 ENOG4105VRR gCN5-related N-acetyltransferase EJW27_17735 ENOG4105KT7 mgtC SapB transporter EJW27_17745 ENOG4107VMI polysaccharide deacetylase EJW27_17760 ENOG4108KGH TRANSCRIPTIONal EJW27_17785 ENOG4105D6E homoserine dehydrogenase EJW27_17805 ENOG4108ZJ4 polysaccharide deacetylase EJW27_17830 ENOG4105EFI regulatoR EJW27_17890 ENOG4105K64 Glycosyl transferase, family 2 EJW27_17900 ENOG4108JJ8 (ABC) transporter EJW27_17905 ENOG4108JJ9 ABC, transporter EJW27_17910 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EJW27_17915 ENOG4105C4M (Ubiquinol oxidase) subunit I EJW27_17930 ENOG4105MDS 4-oxalocrotonate tautomerase EJW27_17940 ENOG4105SKE transcriptional Regulator LysR family EJW27_17950 ENOG4105C32 Amino acid ABC transporter (Permease) EJW27_17955 ENOG4108IV0 ABC, transporter EJW27_17960 ENOG4105C0Z ABC transporter EJW27_17970 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EJW27_17975 ENOG4108Z7G MaoC domain protein dehydratase EJW27_17990 ENOG4105CKI cobalamin synthesis protein EJW27_18000 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EJW27_18015 ENOG4108TVJ Nitroreductase EJW27_18020 ENOG4107ZXU DSBA oxidoreductase EJW27_18025 ENOG4108Z40 Transcriptional regulator EJW27_18030 ENOG4105GZI Transcriptional regulator EJW27_18035 ENOG4107RT3 EamA-like transporter family EJW27_18045 ENOG4105KTB nuclear export factor GLE1 EJW27_18095 ENOG4107R16 Multicopper oxidase EJW27_18100 ENOG4107RAQ aminopeptidase EJW27_18155 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) EJW27_18160 ENOG4105D9N nucleoside EJW27_18170 ENOG4107RHR regulatoR EJW27_18200 ENOG4105DEG Vwa containing coxe family protein EJW27_18210 ENOG4105KKX ATPase associated with various cellular activities aaa_5 EJW27_18235 ENOG4105C0X amino acid EJW27_18240 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EJW27_18255 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) EJW27_18275 ENOG41068WN EJW27_18320 ENOG4105DY9 regulatoR EJW27_18335 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EJW27_18340 ENOG4105C6X Major Facilitator EJW27_18365 ENOG4105C7B Threonine dehydratase EJW27_18375 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EJW27_18390 ENOG4105CM2 brancheD-chain amino acid aminotransferase EJW27_18395 ENOG4105CHR reductase EJW27_18400 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EJW27_18430 ENOG4105H67 Protein of unknown function (DUF421) EJW27_18465 ENOG4105C6T cysteine synthase EJW27_18470 ENOG4105EU0 Major facilitator Superfamily EJW27_18475 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EJW27_18490 ENOG4105DXI Major Facilitator superfamily EJW27_18495 ENOG4105CSR polyphosphate kinase 2 EJW27_18525 ENOG4105FVX EJW27_18565 ENOG4105C0D helicase EJW27_18580 ENOG4105C6K Malic enzyme EJW27_18585 ENOG4108IJ0 Aspartate ammonia-lyase EJW27_18595 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) EJW27_18615 ENOG4105CJ1 ABC, transporter EJW27_18655 ENOG4106BRA Membrane EJW27_18680 ENOG4107QIV Cytochrome c biogenesis protein EJW27_18700 ENOG4105EC3 peptidase S51, dipeptidase E EJW27_18705 ENOG4107QJQ Mate efflux family protein EJW27_18725 ENOG4105C9Q fumarate hydratase class II EJW27_18735 ENOG4105VUF Transcriptional regulator EJW27_18740 ENOG4105DFD Na H antiporter EJW27_18755 ENOG4108PJD permease EJW27_18765 ENOG4105CKI cobalamin synthesis protein EJW27_18770 ENOG4108UZ3 Transporter EJW27_18775 ENOG4105DRR Transcriptional regulator, GntR family EJW27_18785 ENOG4105PGM cation diffusion facilitator family transporter EJW27_18830 ENOG4105CVJ phosphoglycerate mutase EJW27_18885 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJW27_18890 ENOG4105DUM transcriptional regulator, lysR family EJW27_18915 ENOG4105KAC Antibiotic biosynthesis monooxygenase EJW27_18950 ENOG4105KTQ flagellar basal-body rod protein EJW27_18955 ENOG4105FZW flagellar biosynthesis regulator FlhF EJW27_18965 ENOG4105D00 flagellar biosynthetic protein flhB EJW27_18975 ENOG4105VS8 Flagellar biosynthetic protein fliq EJW27_18980 ENOG4105CN7 Flagellar biosynthetic protein FliP EJW27_18990 ENOG4105DD5 Flagellar motor switch protein EJW27_18995 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EJW27_19005 ENOG4105E4C Lytic transglycosylase catalytic EJW27_19010 ENOG4105I03 Flagellin EJW27_19010 ENOG4105I03 Flagellin EJW27_19015 ENOG4105I03 Flagellin EJW27_19025 ENOG4107R88 Chemotaxis protein (CheV) EJW27_19040 ENOG4105BZE flagellar hook protein, FlgE EJW27_19070 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EJW27_19080 ENOG41075Z6 flagellar hook-basal body complex protein fliE EJW27_19085 ENOG4108ZC9 flagellar basal-body rod protein flgc EJW27_19090 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EJW27_19110 ENOG4105DTJ flagellar hook-associated protein EJW27_19135 ENOG4105BZU Histidine kinase EJW27_19150 ENOG4105DD5 Flagellar motor switch protein EJW27_19155 ENOG4105CBS Chea signal transduction histidine kinase EJW27_19160 ENOG4107YTP response regulator receiver protein EJW27_19180 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EJW27_19240 ENOG41080C8 DUF218 domain EJW27_19245 ENOG4105H67 Protein of unknown function (DUF421) EJW27_19255 ENOG4108Z5V transcriptional regulator, merr family EJW27_19260 ENOG4105CN5 Metallo-Beta-Lactamase EJW27_19265 ENOG4107RWR Sodium hydrogen exchanger EJW27_19275 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EJW27_19340 ENOG41081VK Ribonuclease EJW27_19435 ENOG4106032 Glutathionylspermidine synthase EJW27_19470 ENOG4108W0I acetyltransferase EJW27_19485 ENOG4105DHF Membrane EJW27_19490 ENOG4105C2W permease EJW27_19495 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) EJW27_19500 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EJW27_19510 ENOG4105CTD carboxy-peptidase EJW27_19515 ENOG4105DVT helicase EJW27_19525 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EJW27_19540 ENOG4106F55 Protein of unknown function (DUF1273) EJW27_19590 ENOG4105CSM endonuclease III EJW27_19610 ENOG4105YAC EJW27_19630 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EJW27_19655 ENOG4105CPK Glycosyl transferase (Group 1 EJW27_19660 ENOG4105FJR Lmbe family EJW27_19675 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase EJW27_19685 ENOG4108JYZ YitT family EJW27_19720 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EJW27_19725 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) EJW27_19740 ENOG41068YB TPR repeat-containing protein EJW27_19765 ENOG4105EAH synthase EJW27_19775 ENOG4105XXQ heptaprenyl diphosphate synthase component I EJW27_19790 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) EJW27_19820 ENOG41065D1 EJW27_19825 ENOG4105S2F EJW27_19860 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase EJW27_19885 ENOG4108S6Z Negative regulator of genetic competence EJW27_19890 ENOG4107X2D transcriptional regulator, merr family EJW27_19895 ENOG4107RGJ metallophosphoesterase EJW27_19905 ENOG4105I7S Abortive infection protein EJW27_19925 ENOG4108SAX Membrane EJW27_19940 ENOG4108WBT adenosyltransferase EJW27_19945 ENOG4105BZU Histidine kinase EJW27_19950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJW27_19980 ENOG4108JIC nucleoside recognition domain protein EJW27_19990 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EJW27_20020 ENOG4105BZU Histidine kinase EJW27_20035 ENOG4105I3N Conserved Protein EJW27_20040 ENOG4105BZU Histidine kinase EJW27_20060 ENOG4107GRR phosphate transport regulator EJW27_20065 ENOG4105CJ3 phosphate transporter EJW27_20110 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) EJW27_20130 ENOG4105WH1 Two component transcriptional regulator luxr family EJW27_20155 ENOG4105DFD Na H antiporter EJW27_20175 ENOG4105C8J )-transporter EJW27_20185 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein EJW27_20190 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein EJW27_20195 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EJW27_20210 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) EJW27_20230 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EJW27_20240 ENOG4105E0M Sulfatase EJW27_20245 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EJW27_20260 ENOG4107RVV histidinol phosphate phosphatase, hisj family EJW27_20335 ENOG4108ZP8 Acetolactate synthase small subunit EJW27_20340 ENOG4105C7K acetolactate synthase EJW27_20370 ENOG4105KBJ sporulation protein ytfj EJW27_20415 ENOG4107QMU Mate efflux family protein EJW27_20455 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein EJW27_20465 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD EJW27_20480 ENOG4105D7V transposase EJW27_20495 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EJW27_20535 ENOG4105CJ1 ABC, transporter EJW27_20545 ENOG4105CZV ABC transporter EJW27_20555 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EJW27_20570 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) EJW27_20615 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EJW27_20620 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase EJW27_20625 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EJW27_20630 ENOG4105BZU Histidine kinase EJW27_20635 ENOG4106DF1 EJW27_20645 ENOG41090MY MarR family Transcriptional regulator EJW27_20650 ENOG4105BZU Histidine kinase EJW27_20660 ENOG4105PXI polysaccharide deacetylase EJW27_20670 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) EJW27_20700 ENOG4107RCV ABC transporter, permease EJW27_20705 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EJW27_20710 ENOG4105C4Y ABC transporter EJW27_20740 ENOG4105CHR reductase EJW27_20760 ENOG4108Z7G MaoC domain protein dehydratase EJW27_20765 ENOG410681C small acid-soluble spore protein EJW27_20780 ENOG4108QTI )-transporter EJW27_20790 ENOG4106A3R peptidase EJW27_20810 ENOG4105JXH GntR family transcriptional regulator EJW27_20815 ENOG4105BZU Histidine kinase EJW27_20820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJW27_20835 ENOG4105CQB FAD linked oxidase domain protein EJW27_20840 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EJW27_20845 ENOG4105K4I Scp-like extracellular EJW27_20865 ENOG4105EYF MMPL domain protein EJW27_20875 ENOG4107RUE extracellular solute-binding protein family 1 EJW27_20880 ENOG4105D38 putrescine abc transporter EJW27_20885 ENOG4105F38 ABC transporter, permease EJW27_20895 ENOG4105C26 Dehydrogenase EJW27_20930 ENOG4105VFR signal peptidase EJW27_20935 ENOG4105DZ1 carboxypeptidase EJW27_20980 ENOG4105VZ8 Transcriptional regulator EJW27_20990 ENOG4105C7S Dehydrogenase EJW27_21010 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EJW27_21090 ENOG4105DDQ anthranilate synthase EJW27_21095 ENOG4105CRQ synthase (Component I) EJW27_21105 ENOG4105CK7 Sodium proline symporter EJW27_21180 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase EJW27_21195 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) EJW27_21215 ENOG4107TVC Glycosyl transferase, family 2 EJW27_21235 ENOG4105K64 Glycosyl transferase, family 2 EJW27_21255 ENOG4105EMS pseudouridine synthase EJW27_21260 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EJW27_21270 ENOG4106EFP UPF0738 protein EJW27_21275 ENOG4105MIX Adenylate cyclase EJW27_21280 ENOG4108Z18 K06886 hemoglobin EJW27_21290 ENOG4105DPN Oligoendopeptidase f EJW27_21310 ENOG4108ZCF integral membrane protein EJW27_21330 ENOG4105UQX Mate efflux family protein EJW27_21335 ENOG4108JQ7 (ABC) transporter EJW27_21345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJW27_21350 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EJW27_21370 ENOG4105C31 Tryptophanyl-tRNA synthetase EJW27_21385 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EJW27_21390 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EJW27_21425 ENOG4108KP7 hydrolase EJW27_21435 ENOG41073B9 EJW27_21450 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EJW27_21455 ENOG4105QNR S1 RNA binding domain protein EJW27_21460 ENOG4108VPT UPF0234 protein EJW27_21470 ENOG4107A6P EJW27_21485 ENOG4105CH6 catalase EJW27_21520 ENOG4105ERH Fumarylacetoacetate hydrolase EJW27_21575 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EJW27_21620 ENOG4105VEQ Cold shock protein EJW27_21635 ENOG4107QP3 malate synthase g EJW27_21655 ENOG4105C8Q Methyl-accepting chemotaxis EJW27_21680 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EJW27_21695 ENOG41086D8 Transcriptional regulator EJW27_21705 ENOG4108AEY RNA polymerase sigma factor EJW27_21715 ENOG4107TVP HD domain protein EJW27_21730 ENOG4108JGH Tetr family transcriptional regulator EJW27_21780 ENOG4105CEY Amp-dependent synthetase and ligase EJW27_21790 ENOG4105DF9 Lipoate-protein, ligase EJW27_21795 ENOG4108RQ5 Beta-lactamase domain-containing protein EJW27_21800 ENOG4106AXD EJW27_21810 ENOG4105D29 Helix-turn-helix type 11 domain protein EJW27_21835 ENOG4105ECB domain protein EJW27_21850 ENOG4105NA0 Transcriptional regulator EJW27_21880 ENOG4105C1Q protoporphyrinogen oxidase EJW27_21900 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation EJW27_21905 ENOG4105CKV Membrane EJW27_21910 ENOG410905X membrane-flanked domain protein EJW27_21945 ENOG4105CKV Membrane EJW27_21950 ENOG410905X membrane-flanked domain protein EJW27_21980 ENOG4105K59 histidine triad (HIT) protein EJW27_22005 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EJW27_22010 ENOG4105EEM helicase EJW27_22025 ENOG4105CNI cell division protein FtsW EJW27_22035 ENOG4105EMN RNA polymerase sigma factor EJW27_22040 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EJW27_22055 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator EJW27_22085 ENOG4108MUZ hydrolase EJW27_22155 ENOG4108VB1 regulatoR EJW27_22160 ENOG4105ENE Histidine kinase EJW27_22175 ENOG4105K8R UPF0145 protein EJW27_22195 ENOG4105BZU Histidine kinase EJW27_22200 ENOG4105BZU Histidine kinase EJW27_22205 ENOG4108MJI response regulator EJW27_22215 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EJW27_22225 ENOG4105WN5 stage II sporulation protein EJW27_22255 ENOG4108WC5 Alpha Beta Hydrolase Fold protein EJW27_22300 ENOG4105FBW Monooxygenase EJW27_22320 ENOG4105CMT Dihydroxyacetone kinase EJW27_22335 ENOG4105CMT Dihydroxyacetone kinase EJW27_22365 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase EJW27_22375 ENOG4105CS2 ec 3.2.1.21 EJW27_22380 ENOG4105C5Y PTS System EJW27_22385 ENOG4105CID antiterminator EJW27_22435 ENOG4105C0R drug resistance transporter emrb qaca subfamily EJW27_22505 ENOG4107SCJ type I restriction enzyme EcoKI subunit R EJW27_22530 ENOG4108MRH transcriptional regulatory protein EJW27_22540 ENOG4105CSH Transporter EJW27_22635 ENOG4108JQ7 (ABC) transporter EJW27_22645 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJW27_22730 ENOG4105GMB type VI secretion system effector, hcp1 family EJW27_22740 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) EJW27_22745 ENOG4108IBT Inherit from COG: transposase EJW27_22790 ENOG4105DER m42 family EJW27_22805 ENOG4105CGU Enoyl-CoA hydratase EJW27_22820 ENOG4105IEH endo-beta-N-acetylglucosaminidase EJW27_22855 ENOG4105CHH sulfate transporter EJW27_22870 ENOG4105CEY Amp-dependent synthetase and ligase EJW27_22875 ENOG4105D4P Coproporphyrinogen iii oxidase EJW27_22900 ENOG4107FQX Alpha-acetolactate decarboxylase EJW27_22920 ENOG4105WZB UPF0342 protein EJW27_22935 ENOG410839P EJW27_22950 ENOG4105CDA abc transporter atp-binding protein EJW27_22955 ENOG4105DRP amino acid AbC transporter EJW27_22970 ENOG4105BZ1 (ABC) transporter EJW27_22975 ENOG4105BZ1 (ABC) transporter EJW27_22985 ENOG4105C26 Dehydrogenase EJW27_22995 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EJW27_23000 ENOG4105D5Q Arginine ornithine antiporter EJW27_23010 ENOG4107RKG DJ-1/PfpI family EJW27_23025 ENOG4105NF4 modulator of drug activity EJW27_23050 ENOG4105KPY Small multidrug resistance protein EJW27_23055 ENOG4105KPY Small multidrug resistance protein EJW27_23065 ENOG4108YXU transcriptional regulator AsnC family EJW27_23105 ENOG4106KNT transcriptional regulator EJW27_23115 ENOG4107RWR Sodium hydrogen exchanger EJW27_23120 ENOG4105CUB amino acid EJW27_23150 ENOG4107T5V SNARE associated Golgi EJW27_23185 ENOG4105WEF catalase EJW27_23210 ENOG4105C19 ABC transporter EJW27_23215 ENOG4107RBB ABC transporter, permease EJW27_23220 ENOG41069ER domain protein EJW27_23240 ENOG4105VZJ PTS System EJW27_23245 ENOG4105VCP PTS System EJW27_23250 ENOG4105EMD TRANSCRIPTIONal EJW27_23290 ENOG41087NI Sulfite exporter TauE/SafE EJW27_23295 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase EJW27_23305 ENOG4105VFE sira family EJW27_23310 ENOG4105VFE sira family EJW27_23315 ENOG4107TPS domain protein EJW27_23320 ENOG4105VFE sira family EJW27_23325 ENOG4105XTG Pfam:DUF156 EJW27_23330 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase EJW27_23355 ENOG4105ED1 spovr family EJW27_23360 ENOG4107Y03 Nitroreductase EJW27_23400 ENOG4105K63 Thioredoxin EJW27_23415 ENOG4105C5Y PTS System EJW27_23445 ENOG4105C7N Xanthine uracil vitamin C permease EJW27_23460 ENOG4108INS Transcriptional regulator EJW27_23510 ENOG4105DWF phosphomethylpyrimidine kinase EJW27_23515 ENOG4105D06 uba thif-type nad fad binding protein EJW27_23530 ENOG41080HI glycine oxidase EJW27_23535 ENOG4108VEU Thiamine monophosphate synthase EJW27_23545 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EJW27_23555 ENOG4105ETU transcriptional activator (TenA EJW27_23575 ENOG41080XQ Signal transduction protein with cbs domains EJW27_23705 ENOG4105E2Z phosphate ABC transporter (Permease EJW27_23715 ENOG4105CVA phosphate EJW27_23720 ENOG4105CE1 Ferrous iron transport protein b EJW27_23725 ENOG4105CE1 Ferrous iron transport protein b EJW27_23730 ENOG4105CE1 Ferrous iron transport protein b EJW27_23735 ENOG4108NHD germination protein EJW27_23750 ENOG4105E1V na solute symporter EJW27_23755 ENOG4106CAD Protein of unknown function (DUF3311) EJW27_23775 ENOG4105E2S oxidase) subunit II EJW27_23780 ENOG4105BZ9 Cytochrome C oxidase, subunit I EJW27_23805 ENOG4105MA6 gCN5-related N-acetyltransferase EJW27_23820 ENOG4105C7N Xanthine uracil vitamin C permease EJW27_23825 ENOG4105C85 amino acid EJW27_23860 ENOG4107D63 EJW27_23865 ENOG4105VZ8 Transcriptional regulator EJW27_23870 ENOG41069ER domain protein EJW27_23875 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer EJW27_23880 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EJW27_23945 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EJW27_23955 ENOG4105CNN ABC, transporter EJW27_23960 ENOG4105C2J ABC transporter EJW27_23970 ENOG4108RVA ribokinase EJW27_23975 ENOG4105ETE Transcriptional regulator (LacI family EJW27_23985 ENOG41067TZ transcriptional regulator, MarR family EJW27_23990 ENOG4105CXY transporter EJW27_24000 ENOG4108JQ7 (ABC) transporter EJW27_24005 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EJW27_24025 ENOG41068KF Universal stress protein EJW27_24030 ENOG4105CHH sulfate transporter EJW27_24045 ENOG4105BZU Histidine kinase EJW27_24050 ENOG4105NAE bifunctional deaminase-reductase domain protein EJW27_24055 ENOG4105D29 Helix-turn-helix type 11 domain protein EJW27_24085 ENOG4105DRP amino acid AbC transporter EJW27_24090 ENOG4105EAD ABC transporter EJW27_24095 ENOG4105CT1 (ABC) transporter EJW27_24115 ENOG4105CRN Aminoglycoside phosphotransferase EJW27_24120 ENOG4105E1K spore germination protein EJW27_24135 ENOG4105CG3 alpha amylase, catalytic region EJW27_24145 ENOG4107414 GntR family transcriptional regulator EJW27_24150 ENOG4105D5Q Arginine ornithine antiporter EJW27_24170 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EJW27_24175 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EJW27_24180 ENOG4107T89 von Willebrand factor, type A EJW27_24190 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EJW27_24195 ENOG4105EXW epimerase dehydratase EJW27_24210 ENOG4105E0A ABC, transporter EJW27_24215 ENOG4108IHU transport system permease protein EJW27_24225 ENOG4108MES Periplasmic binding protein EJW27_24230 ENOG4105DUX Transporter EJW27_24250 ENOG4105DAA L-lactate EJW27_24255 ENOG4108IJ0 Aspartate ammonia-lyase EJW27_24260 ENOG4105C37 (CBS) domain EJW27_24270 ENOG4105D9N nucleoside EJW27_24280 ENOG41073R8 VanW family EJW27_24310 ENOG4105DAP Nicotinate phosphoribosyltransferase EJW27_24315 ENOG4105C59 p-type ATPase EJW27_24325 ENOG4105CUB amino acid EJW27_24345 ENOG4108JB9 formate dehydrogenase EJW27_24350 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EJW27_24355 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EJW27_24360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EJW27_24365 ENOG4105BZU Histidine kinase EJW27_24375 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EJW27_24380 ENOG4108UZ3 Transporter EJW27_24390 ENOG4105C6K Malic enzyme EJW27_24400 ENOG4108MRH transcriptional regulatory protein EJW27_24425 ENOG4105US7 Histidine kinase EJW27_24430 ENOG4108STX response regulator EJW27_24435 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) EJW27_24455 ENOG4105D4T Citrate transporter EJW27_24465 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EJW27_24475 ENOG4105DZ6 Band 7 protein EJW27_24490 ENOG4105C94 Transporter EJW27_24505 ENOG4105CYN Serine protein kinase EJW27_24510 ENOG4105BZU Histidine kinase EJW27_24515 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EJW27_24525 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EJW27_24535 ENOG4108R9S DSBA oxidoreductase EJW27_24540 ENOG4108JQC penicillin-binding protein 1A EJW27_24695 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EJW27_24705 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EJW27_24710 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein EJW27_24735 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) EJW27_24740 ENOG4105CPF Cell wall formation (By similarity) EJW27_24760 ENOG4105ERH Fumarylacetoacetate hydrolase EJW27_24765 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase EJW27_24795 ENOG410667J hydrolase EJW27_24800 ENOG4108JQ7 (ABC) transporter EJW27_24805 ENOG4105C3U ABC transporter EJW27_24820 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein EJW27_24825 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein EJW27_24835 ENOG4105C5H ABC transporter EJW27_24860 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) EJW27_24875 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EJW27_24895 ENOG4105F6E Acyl-transferase EJW27_24925 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family EJW27_24930 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EJW27_24935 ENOG4105E0C molybdate abc transporter EJW27_24950 ENOG4108J59 Extracellular solute-binding protein, family 5 EJW27_24955 ENOG4108J59 Extracellular solute-binding protein, family 5 EJW27_24985 ENOG4108JQ7 (ABC) transporter EJW27_24990 ENOG4105C3U ABC transporter EJW27_24995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EJW27_25000 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EJW27_25015 ENOG4105C2C drug resistance transporter, Bcr CflA EJW27_25030 ENOG4105IQ5 FAD linked oxidase domain protein EJW27_25040 ENOG4105EE1 crotonyl-CoA reductase EJW27_25045 ENOG4105D01 (LipO)protein EJW27_25055 ENOG4108UMI ABC transporter, permease EJW27_25060 ENOG4108PSK reductase EJW27_25065 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EJW27_25075 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein EJW27_25080 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EJW27_25095 ENOG4107U5W ybbr family EJW27_25100 ENOG4105C8B TIGR00159 family EJW27_25195 ENOG4105D1F ATP-binding protein EJW27_25225 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) EJW27_25260 ENOG41067V7 50S ribosomal protein L36 EJW27_25270 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EJW27_25280 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EJW27_25305 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EJW27_25425 ENOG4107Y49 methyltransferase EJW27_25450 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EJW27_25465 ENOG4105QIV RNA polymerase EJW27_25470 ENOG4105M0M Tetracycline resistance protein EJW27_25475 ENOG4105C2N RNA methyltransferase TrmH family group 3 EJW27_25490 ENOG4105D7W serine acetyltransferase EJW27_25510 ENOG4105CTP PilT protein domain protein EJW27_25520 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EJW27_25535 ENOG4108Z0C Uvrb UvrC protein EJW27_25630 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EJW27_25640 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EJW27_25645 ENOG4105KRF dihydroneopterin aldolase EJW27_25650 ENOG4105EEI dihydropteroate synthase EJW27_25655 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 EJW27_25660 ENOG4105DDQ anthranilate synthase EJW27_25665 ENOG4105CRQ synthase (Component I) EJW27_25685 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EJW27_25690 ENOG4108UGV hypoxanthine phosphoribosyltransferase EJW27_25715 ENOG41060GV RNA binding s1 domain protein EJW27_25730 ENOG4105VYY sporulation protein yabp EJW27_25735 ENOG41082I2 s4 domain protein EJW27_25740 ENOG4108IY2 MazG family EJW27_25770 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EJW27_25785 ENOG4105KME endoribonuclease L-psp EJW27_25790 ENOG4105DFT pur operon repressor EJW27_25805 ENOG4105W42 Veg protein EJW27_25810 ENOG4105XFA sporulation peptidase YabG EJW27_25820 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) EJW27_25825 ENOG4105F8V Hydrolase, tatD family EJW27_25840 ENOG4105KRN Transcriptional regulator, abrb family EJW27_25845 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EJW27_25855 ENOG41060K3 Methyltransferase EJW27_25865 ENOG4105MA4 psp1 domain protein EJW27_25870 ENOG4105FA2 dna polymerase iii EJW27_25880 ENOG4105CXN decarboxylase EJW27_25915 ENOG41067KS pro-sigma K processing EJW27_25935 ENOG4105C6E dna polymerase iii EJW27_25945 ENOG4108Z6B deaminase EJW27_25955 ENOG4105GTG Isochorismatase EJW27_25965 ENOG4105ZMH deoxynucleoside kinase EJW27_26000 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EJW27_26035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EJW27_26050 ENOG410848D S4 domain protein YaaA EJW27_26055 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)