locus-tag	class	description
I4W80_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I4W80_00010	COG0592	DNA-directed DNA polymerase activity
I4W80_00015	COG2501	S4 domain
I4W80_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I4W80_00030	COG0187	DNA topoisomerase II activity
I4W80_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I4W80_00070	COG0516	GMP reductase activity
I4W80_00070	COG0517	IMP dehydrogenase activity
I4W80_00075	COG1686	Belongs to the peptidase S11 family
I4W80_00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4W80_00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I4W80_00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I4W80_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I4W80_00100	COG0840	transmembrane signaling receptor activity
I4W80_00110	COG1428	Deoxynucleoside kinase
I4W80_00115	COG1428	Deoxynucleoside kinase
I4W80_00120	COG1388	LysM domain
I4W80_00120	COG3858	chitin binding
I4W80_00125	COG1335	isochorismatase
I4W80_00130	COG0590	tRNA wobble adenosine to inosine editing
I4W80_00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I4W80_00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I4W80_00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I4W80_00195	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I4W80_00200	COG3853	Toxic anion resistance protein (TelA)
I4W80_00205	COG1982	Orn Lys Arg decarboxylase major
I4W80_00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I4W80_00215	COG3870	Protein conserved in bacteria
I4W80_00220	COG1728	Protein conserved in bacteria
I4W80_00225	COG0470	DNA polymerase III
I4W80_00230	COG1774	PSP1 C-terminal conserved region
I4W80_00235	COG4467	Involved in initiation control of chromosome replication
I4W80_00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I4W80_00245	COG2827	Endonuclease containing a URI domain
I4W80_00250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I4W80_00255	COG2002	toxin-antitoxin pair type II binding
I4W80_00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4W80_00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4W80_00265	COG0084	hydrolase, TatD family'
I4W80_00270	COG3584	3D domain protein
I4W80_00270	COG3583	domain protein
I4W80_00275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I4W80_00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I4W80_00290	COG4466	Protein conserved in bacteria
I4W80_00300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I4W80_00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I4W80_00310	COG0251	oxidation-reduction process
I4W80_00315	COG2088	sporulation resulting in formation of a cellular spore
I4W80_00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I4W80_00330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I4W80_00335	COG0193	aminoacyl-tRNA hydrolase activity
I4W80_00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I4W80_00350	COG2002	toxin-antitoxin pair type II binding
I4W80_00355	COG2244	polysaccharide biosynthetic process
I4W80_00360	COG3956	TIGRFAM MazG family protein
I4W80_00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I4W80_00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I4W80_00385	COG1098	S1 RNA binding domain
I4W80_00400	COG2208	phosphoserine phosphatase activity
I4W80_00405	COG2304	oxidoreductase activity
I4W80_00410	COG0515	serine threonine protein kinase
I4W80_00415	COG0037	tRNA processing
I4W80_00420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I4W80_00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I4W80_00430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I4W80_00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I4W80_00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I4W80_00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I4W80_00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I4W80_00455	COG0512	Glutamine amidotransferase of anthranilate synthase
I4W80_00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I4W80_00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I4W80_00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I4W80_00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I4W80_00480	COG1396	sequence-specific DNA binding
I4W80_00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I4W80_00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I4W80_00570	COG4463	regulation of RNA biosynthetic process
I4W80_00575	COG3880	PFAM UvrB UvrC protein
I4W80_00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I4W80_00585	COG0542	response to heat
I4W80_00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I4W80_00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I4W80_00600	COG4956	integral membrane protein (PIN domain superfamily)
I4W80_00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I4W80_00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I4W80_00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I4W80_00620	COG1045	serine acetyltransferase
I4W80_00625	COG0215	cysteine-tRNA ligase activity
I4W80_00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I4W80_00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I4W80_00640	COG3688	RNA-binding protein containing a PIN domain
I4W80_00645	COG1595	DNA-templated transcription, initiation
I4W80_00650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I4W80_00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I4W80_00660	COG0250	Participates in transcription elongation, termination and antitermination
I4W80_00670	COG0081	regulation of translation
I4W80_00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I4W80_00680	COG0222	ribosome binding
I4W80_00685	COG2813	Specifically methylates the guanine in position
I4W80_00690	COG0085	RNA polymerase activity
I4W80_00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I4W80_00700	COG1358	cellular component organization or biogenesis
I4W80_00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I4W80_00710	COG0049	tRNA binding
I4W80_00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I4W80_00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I4W80_00725	COG0596	Alpha beta hydrolase
I4W80_00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I4W80_00740	COG0088	Forms part of the polypeptide exit tunnel
I4W80_00745	COG0089	rRNA binding
I4W80_00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I4W80_00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I4W80_00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I4W80_00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I4W80_00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I4W80_00775	COG0255	Belongs to the universal ribosomal protein uL29 family
I4W80_00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I4W80_00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I4W80_00790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I4W80_00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I4W80_00800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I4W80_00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I4W80_00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I4W80_00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I4W80_00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I4W80_00825	COG1841	ribosomal large subunit assembly
I4W80_00830	COG0200	Binds to the 23S rRNA
I4W80_00835	COG0201	protein transport
I4W80_00840	COG0563	adenylate kinase activity
I4W80_00845	COG0024	Methionine aminopeptidase
I4W80_00850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I4W80_00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I4W80_00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I4W80_00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I4W80_00870	COG0202	RNA polymerase activity
I4W80_00875	COG0203	ribosomal protein L17
I4W80_00880	COG1122	ATPase activity
I4W80_00885	COG1122	ATPase activity
I4W80_00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I4W80_00895	COG0101	tRNA pseudouridine synthase activity
I4W80_00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I4W80_00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I4W80_00910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I4W80_00935	COG0860	N-Acetylmuramoyl-L-alanine amidase
I4W80_00940	COG0489	protein tyrosine kinase activity
I4W80_00950	COG2194	sulfuric ester hydrolase activity
I4W80_00955	COG0726	polysaccharide deacetylase
I4W80_00985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I4W80_00990	COG0659	secondary active sulfate transmembrane transporter activity
I4W80_00995	COG0385	Bile acid
I4W80_01000	COG3876	Protein conserved in bacteria
I4W80_01005	COG1472	Belongs to the glycosyl hydrolase 3 family
I4W80_01010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I4W80_01015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_01015	COG1263	PTS System
I4W80_01020	COG1737	Transcriptional regulator
I4W80_01025	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I4W80_01060	COG1595	DNA-templated transcription, initiation
I4W80_01065	COG5662	AntiSigma factor
I4W80_01070	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I4W80_01075	COG4856	YbbR-like protein
I4W80_01080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I4W80_01085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I4W80_01100	COG1131	(ABC) transporter
I4W80_01110	COG0577	efflux transmembrane transporter activity
I4W80_01110	COG1136	(ABC) transporter
I4W80_01120	COG1695	Transcriptional regulator
I4W80_01145	COG1131	(ABC) transporter
I4W80_01195	COG2311	Membrane
I4W80_01215	COG1476	TRANSCRIPTIONal
I4W80_01225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I4W80_01230	COG2207	Transcriptional regulator
I4W80_01235	COG1309	transcriptional regulator
I4W80_01250	COG1113	amino acid transport
I4W80_01255	COG0584	glycerophosphoryl diester phosphodiesterase
I4W80_01260	COG2271	Major facilitator Superfamily
I4W80_01270	COG1331	Highly conserved protein containing a thioredoxin domain
I4W80_01280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I4W80_01295	COG1131	(ABC) transporter
I4W80_01325	COG1937	Protein conserved in bacteria
I4W80_01330	COG2210	Belongs to the sulfur carrier protein TusA family
I4W80_01340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I4W80_01340	COG0425	Belongs to the sulfur carrier protein TusA family
I4W80_01345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I4W80_01345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I4W80_01350	COG0425	Belongs to the sulfur carrier protein TusA family
I4W80_01355	COG0730	response to heat
I4W80_01370	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I4W80_01375	COG2814	Major facilitator Superfamily
I4W80_01390	COG1846	Transcriptional regulator
I4W80_01395	COG1683	Conserved Protein
I4W80_01405	COG0656	L-ascorbic acid biosynthetic process
I4W80_01410	COG0371	Dehydrogenase
I4W80_01415	COG1054	Belongs to the UPF0176 family
I4W80_01420	COG0531	amino acid
I4W80_01430	COG3711	transcriptional antiterminator
I4W80_01435	COG2190	(PTS) system
I4W80_01435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_01435	COG1263	PTS System
I4W80_01440	COG2723	6-phospho-beta-galactosidase activity
I4W80_01455	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_01455	COG3711	transcriptional antiterminator
I4W80_01460	COG1940	carbohydrate kinase activity
I4W80_01465	COG0383	alpha-mannosidase activity
I4W80_01470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_01475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_01485	COG1404	Belongs to the peptidase S8 family
I4W80_01500	COG0833	amino acid
I4W80_01505	COG2040	homocysteine
I4W80_01510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4W80_01515	COG1695	Transcriptional regulator
I4W80_01530	COG2814	Major facilitator Superfamily
I4W80_01535	COG0456	acetyltransferase
I4W80_01550	COG1404	Belongs to the peptidase S8 family
I4W80_01560	COG1309	transcriptional regulator
I4W80_01565	COG1917	Cupin 2, conserved barrel domain protein
I4W80_01570	COG1063	alcohol dehydrogenase
I4W80_01575	COG1846	Transcriptional regulator
I4W80_01580	COG0318	PFAM AMP-dependent synthetase and ligase
I4W80_01585	COG0531	amino acid
I4W80_01595	COG0596	Alpha beta hydrolase
I4W80_01600	COG1115	amino acid carrier protein
I4W80_01605	COG2066	Belongs to the glutaminase family
I4W80_01610	COG4191	Histidine kinase
I4W80_01615	COG0784	Response regulator, receiver
I4W80_01620	COG1405	negative regulation of cell septum assembly
I4W80_01620	COG3012	SEC-C Motif Domain Protein
I4W80_01630	COG0667	Aldo Keto reductase
I4W80_01635	COG3290	protein histidine kinase activity
I4W80_01640	COG3279	Response regulator of the LytR AlgR family
I4W80_01645	COG4555	ABC transporter
I4W80_01650	COG1668	transmembrane transport
I4W80_01665	COG3773	Cell wall hydrolase
I4W80_01670	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_01680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I4W80_01685	COG2310	stress, protein
I4W80_01690	COG2310	stress, protein
I4W80_01695	COG2310	stress, protein
I4W80_01700	COG0861	Integral membrane protein TerC family
I4W80_01730	COG3853	Toxic anion resistance protein (TelA)
I4W80_01735	COG4175	Glycine betaine
I4W80_01735	COG0517	IMP dehydrogenase activity
I4W80_01740	COG4176	ABC-type proline glycine betaine transport system permease component
I4W80_01745	COG2113	Glycine betaine
I4W80_01760	COG1473	amidohydrolase
I4W80_01765	COG1288	antiporter activity
I4W80_01770	COG0039	L-malate dehydrogenase activity
I4W80_01775	COG1620	l-lactate permease
I4W80_01780	COG1609	Transcriptional regulator
I4W80_01785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I4W80_01790	COG0561	phosphatase activity
I4W80_01795	COG0673	inositol 2-dehydrogenase activity
I4W80_01800	COG0738	Major facilitator superfamily
I4W80_01805	COG1280	lysine exporter protein (LysE YggA)
I4W80_01820	COG3403	YqcI/YcgG family
I4W80_01825	COG1113	amino acid transport
I4W80_01830	COG3665	Urea carboxylase-associated protein
I4W80_01835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I4W80_01845	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_01850	COG0710	3-dehydroquinate dehydratase activity
I4W80_01855	COG0028	Belongs to the TPP enzyme family
I4W80_01865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I4W80_01870	COG2271	Major facilitator Superfamily
I4W80_01885	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I4W80_01890	COG2226	methyltransferase
I4W80_01895	COG0583	DNA-binding transcription factor activity
I4W80_01900	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I4W80_01905	COG3458	cephalosporin-C deacetylase activity
I4W80_01915	COG3541	Predicted nucleotidyltransferase
I4W80_01920	COG0506	proline dehydrogenase activity
I4W80_01925	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_01930	COG2508	Transcriptional regulator
I4W80_01935	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I4W80_01940	COG0765	amino acid transport
I4W80_01945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_01955	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I4W80_01960	COG1522	sequence-specific DNA binding
I4W80_01965	COG2746	aminoglycoside 3-N-acetyltransferase activity
I4W80_01975	COG3290	protein histidine kinase activity
I4W80_01975	COG0840	transmembrane signaling receptor activity
I4W80_01980	COG3209	COG3209 Rhs family protein
I4W80_02000	COG3842	ATPase activity
I4W80_02005	COG1176	ABC-type spermidine putrescine transport system, permease component I
I4W80_02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I4W80_02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I4W80_02025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I4W80_02040	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I4W80_02045	COG4555	ABC transporter
I4W80_02055	COG0697	spore germination
I4W80_02060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4W80_02070	COG2207	Transcriptional regulator
I4W80_02070	COG3708	Transcriptional regulator
I4W80_02080	COG2364	Membrane
I4W80_02085	COG1126	abc transporter atp-binding protein
I4W80_02090	COG0765	amino acid transport
I4W80_02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_02100	COG0833	amino acid
I4W80_02105	COG3104	oligopeptide transport
I4W80_02110	COG5434	Belongs to the glycosyl hydrolase 28 family
I4W80_02115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I4W80_02120	COG0456	acetyltransferase
I4W80_02125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_02130	COG0765	amino acid transport
I4W80_02135	COG1126	abc transporter atp-binding protein
I4W80_02140	COG1473	amidohydrolase
I4W80_02145	COG2079	MmgE PrpD family protein
I4W80_02150	COG0745	RESPONSE REGULATOR receiver
I4W80_02155	COG5002	protein histidine kinase activity
I4W80_02155	COG3850	Histidine kinase
I4W80_02160	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_02165	COG0527	aspartate kinase activity
I4W80_02170	COG2814	Major facilitator Superfamily
I4W80_02175	COG1309	transcriptional regulator
I4W80_02185	COG0640	Transcriptional regulator
I4W80_02195	COG0583	DNA-binding transcription factor activity
I4W80_02200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4W80_02205	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I4W80_02210	COG0531	amino acid
I4W80_02215	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_02220	COG2249	NAD(P)H dehydrogenase (quinone) activity
I4W80_02225	COG4549	nuclear export factor GLE1
I4W80_02230	COG1276	copper resistance
I4W80_02230	COG2372	response to copper ion
I4W80_02235	COG2213	PTS system mannitol-specific
I4W80_02240	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_02245	COG0246	Mannitol dehydrogenase
I4W80_02250	COG0840	transmembrane signaling receptor activity
I4W80_02285	COG0346	lactoylglutathione lyase activity
I4W80_02295	COG0561	phosphatase activity
I4W80_02345	COG0457	Tetratricopeptide repeat
I4W80_02350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I4W80_02355	COG1914	H( )-stimulated, divalent metal cation uptake system
I4W80_02360	COG4336	lyase activity
I4W80_02365	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I4W80_02370	COG1984	allophanate hydrolase subunit 2
I4W80_02375	COG1414	Transcriptional regulator
I4W80_02380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I4W80_02385	COG2755	lipolytic protein G-D-S-L family
I4W80_02395	COG3711	transcriptional antiterminator
I4W80_02400	COG2226	methyltransferase
I4W80_02405	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_02410	COG3871	stress protein (general stress protein 26)
I4W80_02430	COG2814	Major facilitator Superfamily
I4W80_02435	COG1802	Transcriptional regulator
I4W80_02440	COG1917	Cupin 2, conserved barrel domain protein
I4W80_02440	COG2207	Transcriptional regulator
I4W80_02445	COG0697	spore germination
I4W80_02450	COG0473	3-isopropylmalate dehydrogenase activity
I4W80_02460	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I4W80_02465	COG3706	GGDEF domain
I4W80_02470	COG5298	Protein conserved in bacteria
I4W80_02475	COG1215	transferase activity, transferring glycosyl groups
I4W80_02485	COG0531	amino acid
I4W80_02490	COG0028	Belongs to the TPP enzyme family
I4W80_02495	COG5444	nuclease activity
I4W80_02515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I4W80_02520	COG1914	H( )-stimulated, divalent metal cation uptake system
I4W80_02525	COG2261	transglycosylase associated protein
I4W80_02530	COG2217	Heavy metal translocating P-type atpase
I4W80_02535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I4W80_02540	COG3290	protein histidine kinase activity
I4W80_02545	COG4565	transcriptional regulatory protein
I4W80_02550	COG1301	dicarboxylic acid transport
I4W80_02555	COG0628	permease
I4W80_02560	COG1301	dicarboxylic acid transport
I4W80_02565	COG1131	(ABC) transporter
I4W80_02570	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I4W80_02585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_02590	COG1181	Belongs to the D-alanine--D-alanine ligase family
I4W80_02595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I4W80_02610	COG0513	Belongs to the DEAD box helicase family
I4W80_02615	COG3402	PFAM membrane-flanked domain
I4W80_02620	COG3428	Bacterial PH domain
I4W80_02625	COG0705	Rhomboid family
I4W80_02630	COG0736	holo-[acyl-carrier-protein] synthase activity
I4W80_02635	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I4W80_02640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I4W80_02645	COG0864	Transcriptional regulator
I4W80_02650	COG2337	Toxic component of a toxin-antitoxin (TA) module
I4W80_02655	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_02660	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_02665	COG2172	sigma factor antagonist activity
I4W80_02670	COG2208	phosphoserine phosphatase activity
I4W80_02675	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_02680	COG2172	sigma factor antagonist activity
I4W80_02685	COG1191	sigma factor activity
I4W80_02690	COG2208	phosphoserine phosphatase activity
I4W80_02695	COG2183	response to ionizing radiation
I4W80_02705	COG3091	SprT-like family
I4W80_02710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I4W80_02715	COG0022	dehydrogenase e1 component
I4W80_02720	COG0508	dehydrogenase complex catalyzes the overall conversion of
I4W80_02725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I4W80_02730	COG3284	Transcriptional regulator
I4W80_02775	COG1278	Cold shock
I4W80_02790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_02790	COG1263	PTS System
I4W80_02790	COG2190	(PTS) system
I4W80_02795	COG3394	polysaccharide catabolic process
I4W80_02800	COG3711	transcriptional antiterminator
I4W80_02805	COG1064	alcohol dehydrogenase
I4W80_02810	COG0789	Transcriptional regulator
I4W80_02830	COG0477	Major facilitator Superfamily
I4W80_02835	COG0657	acetylesterase activity
I4W80_02845	COG4221	oxidoreductase activity
I4W80_02855	COG0252	asparaginase activity
I4W80_02875	COG2814	Major facilitator Superfamily
I4W80_02920	COG1309	transcriptional regulator
I4W80_02925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I4W80_02930	COG1846	Transcriptional regulator
I4W80_02935	COG0778	Nitroreductase
I4W80_02950	COG1396	sequence-specific DNA binding
I4W80_02960	COG0456	acetyltransferase
I4W80_02970	COG4122	O-methyltransferase activity
I4W80_02980	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I4W80_02985	COG0697	spore germination
I4W80_02995	COG1301	dicarboxylic acid transport
I4W80_03035	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I4W80_03040	COG0802	atpase or kinase
I4W80_03045	COG1214	PFAM Peptidase M22, glycoprotease
I4W80_03050	COG0456	acetyltransferase
I4W80_03055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I4W80_03060	COG0488	(ABC) transporter
I4W80_03065	COG0315	cyclic pyranopterin monophosphate synthase activity
I4W80_03070	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I4W80_03075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I4W80_03080	COG0805	protein transport
I4W80_03095	COG1266	CAAX protease self-immunity
I4W80_03100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I4W80_03105	COG0459	protein refolding
I4W80_03110	COG1846	Transcriptional regulator
I4W80_03115	COG2808	Putative FMN-binding domain
I4W80_03120	COG1876	peptidase activity
I4W80_03145	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I4W80_03150	COG0823	Involved in the tonB-independent uptake of proteins
I4W80_03160	COG2132	Multicopper oxidase
I4W80_03165	COG1113	amino acid transport
I4W80_03170	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I4W80_03175	COG0714	Associated with various cellular activities
I4W80_03180	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I4W80_03185	COG1305	Transglutaminase-like
I4W80_03190	COG0519	Catalyzes the synthesis of GMP from XMP
I4W80_03190	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I4W80_03195	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I4W80_03205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I4W80_03230	COG1595	DNA-templated transcription, initiation
I4W80_03245	COG2814	Major facilitator Superfamily
I4W80_03250	COG0583	DNA-binding transcription factor activity
I4W80_03255	COG2252	PERMEase
I4W80_03265	COG5583	Uncharacterized small protein (DUF2292)
I4W80_03270	COG3064	Membrane
I4W80_03275	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I4W80_03285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I4W80_03290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I4W80_03295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I4W80_03300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I4W80_03305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I4W80_03310	COG0047	phosphoribosylformylglycinamidine synthase activity
I4W80_03315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I4W80_03320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I4W80_03325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I4W80_03330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I4W80_03335	COG0138	bifunctional purine biosynthesis protein purh
I4W80_03340	COG0151	Belongs to the GarS family
I4W80_03360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I4W80_03365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I4W80_03370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I4W80_03375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I4W80_03385	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I4W80_03390	COG4496	protein, YerC YecD
I4W80_03400	COG0069	glutamate synthase activity
I4W80_03415	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I4W80_03420	COG0210	DNA helicase
I4W80_03425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I4W80_03430	COG4851	CamS sex pheromone cAM373 precursor
I4W80_03435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I4W80_03440	COG1285	pathogenesis
I4W80_03445	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I4W80_03450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I4W80_03455	COG0154	amidase activity
I4W80_03460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I4W80_03465	COG1309	transcriptional regulator
I4W80_03470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I4W80_03480	COG1597	lipid kinase activity
I4W80_03485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I4W80_03490	COG1106	Psort location Cytoplasmic, score
I4W80_03510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I4W80_03525	COG1959	2 iron, 2 sulfur cluster binding
I4W80_03530	COG0492	ferredoxin-NADP+ reductase activity
I4W80_03545	COG1486	melibiose metabolic process
I4W80_03555	COG2211	Major facilitator Superfamily
I4W80_03585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I4W80_03590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I4W80_03595	COG1442	glycosyl transferase family 8
I4W80_03600	COG1216	Glycosyl transferase, family 2
I4W80_03605	COG1442	glycosyl transferase family 8
I4W80_03610	COG2223	nitrite transmembrane transporter activity
I4W80_03620	COG0471	metal ion transport
I4W80_03635	COG0071	Belongs to the small heat shock protein (HSP20) family
I4W80_03650	COG0531	amino acid
I4W80_03655	COG0463	Glycosyl transferase, family 2
I4W80_03655	COG0457	Tetratricopeptide repeat
I4W80_03660	COG0488	(ABC) transporter
I4W80_03665	COG1469	GTP cyclohydrolase I activity
I4W80_03670	COG0789	Transcriptional regulator
I4W80_03675	COG2814	Major facilitator Superfamily
I4W80_03680	COG0488	(ABC) transporter
I4W80_03685	COG0513	Belongs to the DEAD box helicase family
I4W80_03690	COG2130	NADP-dependent
I4W80_03710	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4W80_03710	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4W80_03715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I4W80_03725	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I4W80_03725	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I4W80_03735	COG3290	protein histidine kinase activity
I4W80_03740	COG4565	transcriptional regulatory protein
I4W80_03745	COG3181	Tripartite tricarboxylate transporter family receptor
I4W80_03750	COG2851	Citrate transporter
I4W80_03760	COG3479	Phenolic acid decarboxylase
I4W80_03765	COG1695	Transcriptional regulator
I4W80_03770	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I4W80_03780	COG1254	Belongs to the acylphosphatase family
I4W80_03785	COG2258	MOSC domain
I4W80_03800	COG0024	Methionine aminopeptidase
I4W80_03805	COG1263	PTS System
I4W80_03805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_03830	COG1368	sulfuric ester hydrolase activity
I4W80_03835	COG0076	glutamate decarboxylase activity
I4W80_03840	COG0840	transmembrane signaling receptor activity
I4W80_03850	COG1263	PTS System
I4W80_03850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_03855	COG0366	Alpha amylase catalytic
I4W80_03860	COG2188	Transcriptional regulator
I4W80_03870	COG0737	Belongs to the 5'-nucleotidase family
I4W80_03875	COG0693	protein deglycase activity
I4W80_03880	COG4840	Belongs to the UPF0435 family
I4W80_03885	COG1115	amino acid carrier protein
I4W80_03890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I4W80_03895	COG4980	gas vesicle protein
I4W80_03900	COG1295	ribonuclease BN
I4W80_03910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I4W80_03915	COG0477	Major facilitator Superfamily
I4W80_03925	COG0387	Pfam Sodium calcium exchanger
I4W80_03935	COG0217	transcriptional regulatory protein
I4W80_03945	COG0668	transmembrane transport
I4W80_03950	COG0535	radical SAM domain protein
I4W80_03960	COG0726	polysaccharide deacetylase
I4W80_03970	COG0598	Magnesium transport protein CorA
I4W80_03980	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I4W80_03985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I4W80_04015	COG0789	Transcriptional regulator
I4W80_04020	COG2814	Major facilitator Superfamily
I4W80_04035	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I4W80_04080	COG2076	Multidrug Resistance protein
I4W80_04085	COG2076	Multidrug Resistance protein
I4W80_04090	COG1309	transcriptional regulator
I4W80_04100	COG4637	Psort location Cytoplasmic, score
I4W80_04105	COG2755	lipolytic protein G-D-S-L family
I4W80_04110	COG0492	ferredoxin-NADP+ reductase activity
I4W80_04115	COG2169	Transcriptional regulator
I4W80_04120	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I4W80_04125	COG1132	(ABC) transporter
I4W80_04130	COG1742	UPF0060 membrane protein
I4W80_04135	COG1595	DNA-templated transcription, initiation
I4W80_04155	COG2318	DinB family
I4W80_04165	COG1846	Transcriptional regulator
I4W80_04170	COG0392	lysyltransferase activity
I4W80_04170	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I4W80_04190	COG0778	Nitroreductase
I4W80_04205	COG1090	epimerase
I4W80_04210	COG2137	regulation of response to DNA damage stimulus
I4W80_04235	COG0463	Glycosyl transferase, family 2
I4W80_04240	COG4485	Bacterial membrane protein, YfhO
I4W80_04245	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I4W80_04260	COG2140	Oxalate decarboxylase
I4W80_04270	COG1191	sigma factor activity
I4W80_04280	COG1988	membrane-bound metal-dependent
I4W80_04285	COG1194	a g-specific adenine glycosylase
I4W80_04295	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_04310	COG3557	Belongs to the UPF0374 family
I4W80_04315	COG1132	(ABC) transporter
I4W80_04320	COG0444	Belongs to the ABC transporter superfamily
I4W80_04325	COG4608	Belongs to the ABC transporter superfamily
I4W80_04330	COG0747	negative chemotaxis
I4W80_04335	COG0601	transmembrane transport
I4W80_04340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4W80_04345	COG4129	membrane
I4W80_04350	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I4W80_04355	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I4W80_04360	COG0735	belongs to the Fur family
I4W80_04505	COG1368	sulfuric ester hydrolase activity
I4W80_04510	COG0681	Belongs to the peptidase S26 family
I4W80_04515	COG2873	o-acetylhomoserine
I4W80_04525	COG1116	anion transmembrane transporter activity
I4W80_04530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I4W80_04535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I4W80_04540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I4W80_04555	COG1131	(ABC) transporter
I4W80_04585	COG3382	B3 4 domain protein
I4W80_04590	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I4W80_04600	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I4W80_04605	COG2766	serine protein kinase
I4W80_04610	COG2718	Belongs to the UPF0229 family
I4W80_04615	COG1566	PFAM secretion protein HlyD family protein
I4W80_04620	COG2814	Major facilitator Superfamily
I4W80_04625	COG0655	NAD(P)H dehydrogenase (quinone) activity
I4W80_04635	COG1278	Cold shock
I4W80_04640	COG3706	GGDEF domain
I4W80_04665	COG5577	PFAM Coat F domain
I4W80_04670	COG5002	protein histidine kinase activity
I4W80_04675	COG0737	Belongs to the 5'-nucleotidase family
I4W80_04675	COG1525	nuclease
I4W80_04675	COG4085	toxin activity
I4W80_04680	COG3764	Sortase (surface protein transpeptidase)
I4W80_04690	COG0564	pseudouridine synthase activity
I4W80_04700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I4W80_04705	COG3153	acetyltransferase
I4W80_04705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I4W80_04725	COG3835	regulator
I4W80_04730	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I4W80_04735	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I4W80_04740	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I4W80_04745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I4W80_04750	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I4W80_04755	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I4W80_04760	COG2203	Gaf domain
I4W80_04760	COG4585	Histidine kinase
I4W80_04765	COG2197	response regulator
I4W80_04780	COG0753	catalase activity
I4W80_04785	COG1959	2 iron, 2 sulfur cluster binding
I4W80_04790	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I4W80_04790	COG1017	nitric oxide dioxygenase activity
I4W80_04795	COG2719	SpoVR family
I4W80_04800	COG1785	Belongs to the alkaline phosphatase family
I4W80_04805	COG0791	NLP P60 protein
I4W80_04805	COG1388	LysM domain
I4W80_04810	COG0531	amino acid
I4W80_04825	COG1595	DNA-templated transcription, initiation
I4W80_04830	COG0204	Acyl-transferase
I4W80_04835	COG1253	flavin adenine dinucleotide binding
I4W80_04840	COG0789	Transcriptional regulator
I4W80_04845	COG1253	flavin adenine dinucleotide binding
I4W80_04860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I4W80_04865	COG0584	glycerophosphoryl diester phosphodiesterase
I4W80_04875	COG0668	transmembrane transport
I4W80_04880	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I4W80_04885	COG0726	polysaccharide deacetylase
I4W80_04890	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I4W80_04895	COG0589	response to stress
I4W80_04900	COG1132	(ABC) transporter
I4W80_04905	COG1132	(ABC) transporter
I4W80_04910	COG0702	epimerase
I4W80_04920	COG3842	ATPase activity
I4W80_04925	COG2508	Transcriptional regulator
I4W80_04935	COG0189	ligase activity
I4W80_04940	COG0189	ligase activity
I4W80_04945	COG4399	Belongs to the UPF0754 family
I4W80_04950	COG3679	Belongs to the UPF0342 family
I4W80_04955	COG0561	phosphatase activity
I4W80_04960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I4W80_04970	COG0475	glutathione-regulated potassium exporter activity
I4W80_04975	COG0490	domain, Protein
I4W80_04985	COG1024	Enoyl-CoA hydratase
I4W80_04995	COG0420	3'-5' exonuclease activity
I4W80_05000	COG4717	serine-type aminopeptidase activity
I4W80_05005	COG3481	metal-dependent phosphohydrolase, HD sub domain
I4W80_05015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I4W80_05040	COG1846	Transcriptional regulator
I4W80_05045	COG4980	gas vesicle protein
I4W80_05060	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I4W80_05065	COG0537	adenosine 5'-monophosphoramidase activity
I4W80_05070	COG1131	(ABC) transporter
I4W80_05075	COG4473	ABC transporter
I4W80_05085	COG1473	amidohydrolase
I4W80_05090	COG2329	Antibiotic biosynthesis monooxygenase
I4W80_05095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I4W80_05100	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I4W80_05105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I4W80_05110	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I4W80_05115	COG1309	transcriptional regulator
I4W80_05120	COG1511	domain protein
I4W80_05125	COG1363	Peptidase, m42
I4W80_05130	COG1301	dicarboxylic acid transport
I4W80_05140	COG1234	tRNA 3'-trailer cleavage
I4W80_05145	COG0095	Lipoate-protein ligase
I4W80_05150	COG0318	PFAM AMP-dependent synthetase and ligase
I4W80_05160	COG0501	Belongs to the peptidase M48B family
I4W80_05165	COG1404	Belongs to the peptidase S8 family
I4W80_05170	COG0406	alpha-ribazole phosphatase activity
I4W80_05175	COG0840	transmembrane signaling receptor activity
I4W80_05180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I4W80_05180	COG0723	plastoquinol--plastocyanin reductase activity
I4W80_05185	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_05195	COG4903	ComK protein
I4W80_05210	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4W80_05215	COG2814	Major facilitator Superfamily
I4W80_05220	COG2732	(Barnase) inhibitor
I4W80_05225	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_05230	COG4605	iron ion homeostasis
I4W80_05235	COG4604	ABC transporter, ATP-binding protein
I4W80_05240	COG4607	ABC-type enterochelin transport system periplasmic component
I4W80_05245	COG1316	TRANSCRIPTIONal
I4W80_05260	COG0398	Pfam SNARE associated Golgi protein
I4W80_05265	COG0681	Belongs to the peptidase S26 family
I4W80_05270	COG3180	Ammonia monooxygenase
I4W80_05285	COG2259	Doxx family
I4W80_05290	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
I4W80_05295	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I4W80_05300	COG1074	ATP-dependent DNA helicase activity
I4W80_05305	COG0420	3'-5' exonuclease activity
I4W80_05310	COG0419	ATPase involved in DNA repair
I4W80_05315	COG1403	HNH endonuclease
I4W80_05355	COG5337	Spore coat protein CotH
I4W80_05365	COG0179	Fumarylacetoacetate (FAA) hydrolase
I4W80_05380	COG0367	asparagine synthase
I4W80_05395	COG1562	ergosterol biosynthetic process
I4W80_05400	COG0534	Mate efflux family protein
I4W80_05405	COG1917	Cupin 2, conserved barrel domain protein
I4W80_05405	COG2207	Transcriptional regulator
I4W80_05430	COG0076	glutamate decarboxylase activity
I4W80_05465	COG1410	methionine synthase
I4W80_05465	COG0646	methionine synthase
I4W80_05470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I4W80_05470	COG0646	methionine synthase
I4W80_05475	COG1666	GTP binding
I4W80_05480	COG2996	Protein conserved in bacteria
I4W80_05485	COG1744	ABC transporter substrate-binding protein PnrA-like
I4W80_05490	COG0840	transmembrane signaling receptor activity
I4W80_05495	COG1307	EDD domain protein, DegV family
I4W80_05500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4W80_05520	COG0561	phosphatase activity
I4W80_05525	COG1073	alpha beta
I4W80_05530	COG2151	metal-sulfur cluster biosynthetic enzyme
I4W80_05535	COG0277	FAD linked oxidase domain protein
I4W80_05540	COG2271	Major facilitator Superfamily
I4W80_05545	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I4W80_05550	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I4W80_05555	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I4W80_05560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I4W80_05565	COG0505	Belongs to the CarA family
I4W80_05570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I4W80_05575	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I4W80_05585	COG2814	Major facilitator Superfamily
I4W80_05595	COG2267	carboxylic ester hydrolase activity
I4W80_05605	COG1744	ABC transporter substrate-binding protein PnrA-like
I4W80_05620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I4W80_05625	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I4W80_05630	COG5504	Zn-dependent protease
I4W80_05635	COG0444	Belongs to the ABC transporter superfamily
I4W80_05640	COG4608	Belongs to the ABC transporter superfamily
I4W80_05650	COG0601	transmembrane transport
I4W80_05655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4W80_05665	COG0180	Tryptophanyl-tRNA synthetase
I4W80_05670	COG4166	transmembrane transport
I4W80_05675	COG0601	transmembrane transport
I4W80_05680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4W80_05685	COG0444	Belongs to the ABC transporter superfamily
I4W80_05690	COG4608	Belongs to the ABC transporter superfamily
I4W80_05700	COG0456	acetyltransferase
I4W80_05705	COG1393	Belongs to the ArsC family
I4W80_05710	COG0861	Integral membrane protein TerC family
I4W80_05715	COG4862	establishment of competence for transformation
I4W80_05720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I4W80_05730	COG1164	Oligoendopeptidase f
I4W80_05740	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I4W80_05745	COG2346	COG2346, Truncated hemoglobins
I4W80_05750	COG0741	lytic transglycosylase activity
I4W80_05755	COG4116	CYTH
I4W80_05765	COG2357	RelA SpoT domain protein
I4W80_05770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I4W80_05775	COG0564	pseudouridine synthase activity
I4W80_05780	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I4W80_05785	COG0475	glutathione-regulated potassium exporter activity
I4W80_05785	COG0569	domain protein
I4W80_05790	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I4W80_05795	COG0352	thiamine-phosphate diphosphorylase activity
I4W80_05805	COG2104	thiamine diphosphate biosynthetic process
I4W80_05810	COG2022	thiamine diphosphate biosynthetic process
I4W80_05815	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I4W80_05820	COG0351	phosphomethylpyrimidine kinase
I4W80_05825	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I4W80_05880	COG0210	DNA helicase
I4W80_05890	COG2153	protein acetylation
I4W80_05895	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I4W80_05900	COG2382	esterase
I4W80_05905	COG0626	cystathionine gamma-synthase activity
I4W80_05910	COG0626	cystathionine gamma-synthase activity
I4W80_05920	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I4W80_05940	COG0604	alcohol dehydrogenase
I4W80_05955	COG0825	malonyl-CoA metabolic process
I4W80_05970	COG0457	Tetratricopeptide repeat
I4W80_05980	COG2153	protein acetylation
I4W80_05985	COG2364	Membrane
I4W80_06000	COG0300	oxidoreductase activity
I4W80_06015	COG3173	Aminoglycoside phosphotransferase
I4W80_06020	COG0583	DNA-binding transcription factor activity
I4W80_06040	COG0583	DNA-binding transcription factor activity
I4W80_06045	COG2807	transmembrane transport
I4W80_06070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I4W80_06080	COG1309	transcriptional regulator
I4W80_06090	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I4W80_06095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I4W80_06100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I4W80_06105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I4W80_06125	COG4195	phage-related replication protein
I4W80_06130	COG2856	Zn peptidase
I4W80_06135	COG5632	N-Acetylmuramoyl-L-alanine amidase
I4W80_06135	COG3409	Peptidoglycan-binding domain 1 protein
I4W80_06150	COG0306	phosphate transporter
I4W80_06155	COG1392	Phosphate transport regulator
I4W80_06165	COG0405	Gamma-glutamyltransferase
I4W80_06170	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I4W80_06180	COG4208	sulfate ABC transporter
I4W80_06185	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I4W80_06195	COG3775	system Galactitol-specific IIC component
I4W80_06210	COG1063	alcohol dehydrogenase
I4W80_06215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I4W80_06220	COG0022	dehydrogenase e1 component
I4W80_06220	COG0508	dehydrogenase complex catalyzes the overall conversion of
I4W80_06225	COG0508	dehydrogenase complex catalyzes the overall conversion of
I4W80_06230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I4W80_06235	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_06240	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_06245	COG2390	Transcriptional regulator
I4W80_06255	COG0531	amino acid
I4W80_06260	COG0346	lactoylglutathione lyase activity
I4W80_06265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I4W80_06270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I4W80_06275	COG2362	D-Aminopeptidase
I4W80_06280	COG0601	transmembrane transport
I4W80_06285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4W80_06290	COG0444	Belongs to the ABC transporter superfamily
I4W80_06295	COG4166	transmembrane transport
I4W80_06300	COG1619	proteins homologs of microcin C7 resistance protein MccF
I4W80_06305	COG4948	Mandelate Racemase Muconate Lactonizing
I4W80_06310	COG0791	NLP P60 protein
I4W80_06315	COG4608	Belongs to the ABC transporter superfamily
I4W80_06320	COG1834	amidinotransferase
I4W80_06325	COG1607	acyl-coa hydrolase
I4W80_06330	COG1695	Transcriptional regulator
I4W80_06345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I4W80_06355	COG2076	Multidrug Resistance protein
I4W80_06360	COG2076	Multidrug Resistance protein
I4W80_06370	COG0788	formyltetrahydrofolate deformylase activity
I4W80_06375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I4W80_06380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I4W80_06385	COG0457	Tetratricopeptide repeat
I4W80_06395	COG1764	response to oxidative stress
I4W80_06400	COG1846	Transcriptional regulator
I4W80_06405	COG1764	response to oxidative stress
I4W80_06410	COG0590	tRNA wobble adenosine to inosine editing
I4W80_06415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I4W80_06420	COG1404	Belongs to the peptidase S8 family
I4W80_06435	COG0745	RESPONSE REGULATOR receiver
I4W80_06440	COG5002	protein histidine kinase activity
I4W80_06440	COG3850	Histidine kinase
I4W80_06445	COG3212	peptidase
I4W80_06450	COG3212	peptidase
I4W80_06460	COG2239	Acts as a magnesium transporter
I4W80_06470	COG0583	DNA-binding transcription factor activity
I4W80_06480	COG0789	Transcriptional regulator
I4W80_06495	COG1846	Transcriptional regulator
I4W80_06500	COG3300	MHYT domain
I4W80_06500	COG5001	Diguanylate cyclase
I4W80_06505	COG0586	Pfam SNARE associated Golgi protein
I4W80_06510	COG0861	Integral membrane protein TerC family
I4W80_06515	COG1191	sigma factor activity
I4W80_06535	COG0501	Belongs to the peptidase M48B family
I4W80_06540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I4W80_06545	COG2323	membrane
I4W80_06560	COG3594	Acyltransferase
I4W80_06565	COG5002	protein histidine kinase activity
I4W80_06570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I4W80_06575	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
I4W80_06580	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
I4W80_06585	COG0436	Aminotransferase
I4W80_06590	COG1850	ribulose-bisphosphate carboxylase activity
I4W80_06595	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
I4W80_06600	COG0235	Class ii aldolase
I4W80_06605	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
I4W80_06615	COG3852	Histidine kinase
I4W80_06620	COG1846	Transcriptional regulator
I4W80_06625	COG1360	Flagellar Motor Protein
I4W80_06630	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I4W80_06640	COG0542	response to heat
I4W80_06645	COG3949	Membrane
I4W80_06650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
I4W80_06655	COG0720	synthase
I4W80_06660	COG0602	queuosine metabolic process
I4W80_06665	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
I4W80_06675	COG4873	Protein conserved in bacteria
I4W80_06685	COG3773	Cell wall hydrolase
I4W80_06690	COG2244	polysaccharide biosynthetic process
I4W80_06695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_06700	COG2217	Heavy metal translocating P-type atpase
I4W80_06705	COG0006	proline dipeptidase activity
I4W80_06710	COG1609	Transcriptional regulator
I4W80_06715	COG3711	transcriptional antiterminator
I4W80_06720	COG2190	(PTS) system
I4W80_06720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_06720	COG1263	PTS System
I4W80_06725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_06730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I4W80_06740	COG1533	DNA photolyase activity
I4W80_06745	COG0840	transmembrane signaling receptor activity
I4W80_06755	COG2084	Dehydrogenase
I4W80_06760	COG2340	Cysteine-rich secretory protein family
I4W80_06765	COG0768	penicillin binding
I4W80_06770	COG4191	Histidine kinase
I4W80_06775	COG0436	Aminotransferase
I4W80_06780	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I4W80_06790	COG1714	RDD family
I4W80_06800	COG0835	chemotaxis
I4W80_06800	COG0784	Response regulator, receiver
I4W80_06820	COG2814	Major facilitator Superfamily
I4W80_06825	COG1376	ErfK ybiS ycfS ynhG family protein
I4W80_06830	COG1408	metallophosphoesterase
I4W80_06835	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_06840	COG2200	EAL domain
I4W80_06845	COG3546	catalase activity
I4W80_06850	COG4703	Protein of unknown function (DUF1797)
I4W80_06855	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I4W80_06865	COG0517	IMP dehydrogenase activity
I4W80_06870	COG0583	DNA-binding transcription factor activity
I4W80_06880	COG0716	FMN binding
I4W80_06890	COG0716	FMN binding
I4W80_06895	COG2171	N-acyltransferase activity
I4W80_06900	COG1473	amidohydrolase
I4W80_06910	COG0668	transmembrane transport
I4W80_06915	COG0450	alkyl hydroperoxide reductase
I4W80_06920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_06935	COG0746	molybdenum cofactor guanylyltransferase activity
I4W80_06940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I4W80_06945	COG0303	'Molybdopterin
I4W80_06950	COG1763	Mo-molybdopterin cofactor biosynthetic process
I4W80_06955	COG0314	molybdopterin synthase activity
I4W80_06960	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I4W80_06975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I4W80_06980	COG1136	(ABC) transporter
I4W80_06985	COG0577	efflux transmembrane transporter activity
I4W80_06990	COG1349	DNA-binding transcription factor activity
I4W80_06995	COG1105	Belongs to the carbohydrate kinase PfkB family
I4W80_07000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_07000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_07000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_07005	COG0681	Belongs to the peptidase S26 family
I4W80_07015	COG0488	(ABC) transporter
I4W80_07020	COG2309	aminopeptidase activity
I4W80_07030	COG1077	Cell shape determining protein MreB Mrl
I4W80_07035	COG2002	toxin-antitoxin pair type II binding
I4W80_07040	COG3852	Histidine kinase
I4W80_07045	COG2105	PFAM AIG2 family protein
I4W80_07045	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I4W80_07050	COG0569	domain protein
I4W80_07055	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I4W80_07060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I4W80_07065	COG5503	Protein of unknown function (DUF1447)
I4W80_07070	COG0561	phosphatase activity
I4W80_07075	COG0242	peptide deformylase activity
I4W80_07090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I4W80_07095	COG0022	dehydrogenase e1 component
I4W80_07100	COG0508	dehydrogenase complex catalyzes the overall conversion of
I4W80_07105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I4W80_07110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_07120	COG1982	Orn Lys Arg decarboxylase major
I4W80_07125	COG4476	Belongs to the UPF0223 family
I4W80_07130	COG4493	Belongs to the UPF0637 family
I4W80_07140	COG0483	inositol monophosphate 1-phosphatase activity
I4W80_07155	COG1595	DNA-templated transcription, initiation
I4W80_07175	COG1217	gtp-binding protein TYPA
I4W80_07185	COG4896	Protein conserved in bacteria
I4W80_07195	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I4W80_07200	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I4W80_07205	COG2066	Belongs to the glutaminase family
I4W80_07210	COG4838	Belongs to the UPF0358 family
I4W80_07215	COG0772	Belongs to the SEDS family
I4W80_07220	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I4W80_07225	COG0415	Belongs to the DNA photolyase family
I4W80_07230	COG1612	heme a metabolic process
I4W80_07235	COG0109	protoheme IX farnesyltransferase activity
I4W80_07240	COG2010	Cytochrome c
I4W80_07240	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I4W80_07245	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I4W80_07250	COG1845	cytochrome c oxidase, subunit III
I4W80_07255	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I4W80_07260	COG3336	cytochrome c oxidase
I4W80_07270	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I4W80_07275	COG2340	Cysteine-rich secretory protein family
I4W80_07295	COG3679	Belongs to the UPF0342 family
I4W80_07300	COG4471	UPF0298 protein
I4W80_07305	COG0742	ribosomal rna small subunit methyltransferase
I4W80_07310	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I4W80_07315	COG3314	Sporulation integral membrane protein YlbJ
I4W80_07320	COG1752	Esterase of the alpha-beta hydrolase superfamily
I4W80_07325	COG3480	Lon protease (S16) C-terminal proteolytic domain
I4W80_07335	COG1399	metal-binding, possibly nucleic acid-binding protein
I4W80_07340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I4W80_07350	COG0454	-acetyltransferase
I4W80_07355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I4W80_07360	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I4W80_07365	COG2001	Belongs to the MraZ family
I4W80_07370	COG0275	rRNA processing
I4W80_07375	COG4839	cell division protein FtsL
I4W80_07380	COG0768	penicillin binding
I4W80_07385	COG0768	penicillin binding
I4W80_07390	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I4W80_07395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I4W80_07400	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I4W80_07405	COG0772	Belongs to the SEDS family
I4W80_07410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I4W80_07415	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I4W80_07420	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I4W80_07425	COG3879	Bacterial protein of unknown function (DUF881)
I4W80_07430	COG3879	Bacterial protein of unknown function (DUF881)
I4W80_07435	COG3856	small basic protein
I4W80_07440	COG0849	cell division
I4W80_07445	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I4W80_07450	COG4412	M6 family metalloprotease domain protein
I4W80_07450	COG1404	Belongs to the peptidase S8 family
I4W80_07460	COG1191	sigma factor activity
I4W80_07465	COG1191	sigma factor activity
I4W80_07470	COG2390	Transcriptional regulator
I4W80_07485	COG3730	PTS system glucitol sorbitol-specific
I4W80_07490	COG3732	PTS system glucitol sorbitol-specific
I4W80_07500	COG1119	ATPase activity
I4W80_07505	COG1873	PFAM PRC-barrel domain
I4W80_07510	COG1496	oxidoreductase activity
I4W80_07515	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I4W80_07520	COG1799	cell septum assembly
I4W80_07525	COG0762	integral membrane protein
I4W80_07530	COG2302	S4 RNA-binding domain
I4W80_07535	COG3599	regulation of cell shape
I4W80_07540	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I4W80_07545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I4W80_07550	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I4W80_07555	COG0564	pseudouridine synthase activity
I4W80_07560	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I4W80_07565	COG2233	PERMEase
I4W80_07570	COG0540	Belongs to the ATCase OTCase family
I4W80_07575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I4W80_07580	COG0505	Belongs to the CarA family
I4W80_07585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I4W80_07590	COG0543	2 iron, 2 sulfur cluster binding
I4W80_07595	COG0167	dihydroorotate dehydrogenase activity
I4W80_07600	COG0284	orotidine-5'-phosphate decarboxylase activity
I4W80_07605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I4W80_07615	COG0175	sulfate reduction
I4W80_07620	COG0306	phosphate transporter
I4W80_07625	COG2046	Belongs to the sulfate adenylyltransferase family
I4W80_07630	COG0529	Catalyzes the synthesis of activated sulfate
I4W80_07635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I4W80_07640	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
I4W80_07645	COG1648	precorrin-2 dehydrogenase activity
I4W80_07655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I4W80_07660	COG1561	YicC-like family, N-terminal region
I4W80_07665	COG2052	Domain of unknown function (DUF370)
I4W80_07670	COG0194	GDP metabolic process
I4W80_07675	COG1758	RNA polymerase activity
I4W80_07680	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I4W80_07685	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I4W80_07690	COG0242	peptide deformylase activity
I4W80_07695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I4W80_07700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I4W80_07700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I4W80_07705	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I4W80_07710	COG0631	protein serine/threonine phosphatase activity
I4W80_07715	COG0515	serine threonine protein kinase
I4W80_07715	COG2815	serine threonine protein kinase
I4W80_07720	COG1162	GTPase activity
I4W80_07725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I4W80_07730	COG1564	THIamine pyrophosphokinase
I4W80_07740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I4W80_07745	COG1302	Protein conserved in bacteria
I4W80_07750	COG1461	Dihydroxyacetone kinase
I4W80_07755	COG1760	l-serine dehydratase
I4W80_07760	COG1760	l-serine dehydratase
I4W80_07765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I4W80_07770	COG1349	DNA-binding transcription factor activity
I4W80_07775	COG0416	fatty acid biosynthetic process
I4W80_07780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I4W80_07785	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_07790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I4W80_07800	COG1196	nuclear chromosome segregation
I4W80_07805	COG0552	protein localization to endoplasmic reticulum
I4W80_07810	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I4W80_07815	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I4W80_07820	COG0228	four-way junction DNA binding
I4W80_07825	COG1837	Belongs to the UPF0109 family
I4W80_07835	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I4W80_07840	COG0336	Belongs to the RNA methyltransferase TrmD family
I4W80_07845	COG0335	large ribosomal subunit rRNA binding
I4W80_07850	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I4W80_07855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I4W80_07865	COG2257	FlhB HrpN YscU SpaS Family
I4W80_07870	COG0045	succinate-CoA ligase (ADP-forming) activity
I4W80_07875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I4W80_07880	COG0758	DNA mediated transformation
I4W80_07885	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I4W80_07890	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I4W80_07895	COG4974	Belongs to the 'phage' integrase family
I4W80_07900	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I4W80_07905	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I4W80_07910	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I4W80_07915	COG1815	bacterial-type flagellum-dependent cell motility
I4W80_07920	COG1558	bacterial-type flagellum-dependent cell motility
I4W80_07925	COG1677	Flagellar hook-basal body complex protein FliE
I4W80_07930	COG1766	The M ring may be actively involved in energy transduction
I4W80_07935	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I4W80_07940	COG1317	bacterial-type flagellum organization
I4W80_07945	COG1157	protein secretion by the type III secretion system
I4W80_07950	COG2882	bacterial-type flagellum organization
I4W80_07955	COG3334	PFAM MgtE intracellular
I4W80_07960	COG3144	bacterial-type flagellum assembly
I4W80_07965	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I4W80_07970	COG4786	Flagellar basal body rod
I4W80_07975	COG1582	Flagellar protein (FlbD)
I4W80_07980	COG1580	Controls the rotational direction of flagella during chemotaxis
I4W80_07985	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I4W80_07990	COG1776	CheC inhibitor of MCP methylation
I4W80_07990	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I4W80_07995	COG2201	protein-glutamate methylesterase activity
I4W80_08000	COG3190	flagellar
I4W80_08005	COG1338	Plays a role in the flagellum-specific transport system
I4W80_08010	COG1987	bacterial-type flagellum assembly
I4W80_08015	COG1684	flagellar biosynthetic protein fliR
I4W80_08020	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I4W80_08025	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I4W80_08030	COG1419	protein localization to endoplasmic reticulum
I4W80_08035	COG0455	bacterial-type flagellum organization
I4W80_08040	COG2201	protein-glutamate methylesterase activity
I4W80_08045	COG2198	Histidine kinase
I4W80_08045	COG0643	Histidine kinase
I4W80_08050	COG0835	chemotaxis
I4W80_08055	COG1776	CheC inhibitor of MCP methylation
I4W80_08065	COG1191	sigma factor activity
I4W80_08080	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I4W80_08085	COG0528	UMP kinase activity
I4W80_08090	COG0233	cytoplasmic translational termination
I4W80_08095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I4W80_08100	COG4589	Belongs to the CDS family
I4W80_08105	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I4W80_08110	COG0750	zinc metalloprotease
I4W80_08115	COG0442	prolyl-tRNA aminoacylation
I4W80_08120	COG2176	DNA-directed DNA polymerase activity
I4W80_08135	COG3693	PFAM glycoside hydrolase, family 10
I4W80_08145	COG0779	Required for maturation of 30S ribosomal subunits
I4W80_08150	COG0195	Participates in both transcription termination and antitermination
I4W80_08155	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I4W80_08160	COG1358	cellular component organization or biogenesis
I4W80_08165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I4W80_08170	COG1550	Protein conserved in bacteria
I4W80_08175	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I4W80_08180	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I4W80_08185	COG0196	riboflavin kinase activity
I4W80_08190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I4W80_08195	COG1185	polyribonucleotide nucleotidyltransferase activity
I4W80_08200	COG0726	polysaccharide deacetylase
I4W80_08205	COG0612	Peptidase, M16
I4W80_08215	COG1873	PFAM PRC-barrel domain
I4W80_08220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I4W80_08225	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I4W80_08230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I4W80_08235	COG0527	aspartate kinase activity
I4W80_08245	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I4W80_08250	COG0740	serine-type endopeptidase activity
I4W80_08260	COG4980	gas vesicle protein
I4W80_08260	COG1674	ftsk spoiiie
I4W80_08265	COG2188	Transcriptional regulator
I4W80_08270	COG2814	Major facilitator Superfamily
I4W80_08275	COG2409	Drug exporters of the RND superfamily
I4W80_08275	COG1033	growth of symbiont in host cell
I4W80_08280	COG0612	Peptidase, M16
I4W80_08285	COG0612	Peptidase, M16
I4W80_08295	COG1033	growth of symbiont in host cell
I4W80_08295	COG2409	Drug exporters of the RND superfamily
I4W80_08300	COG0300	oxidoreductase activity
I4W80_08315	COG1426	Protein conserved in bacteria
I4W80_08320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I4W80_08325	COG1058	Belongs to the CinA family
I4W80_08325	COG1546	Belongs to the CinA family
I4W80_08330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I4W80_08335	COG1418	mRNA catabolic process
I4W80_08340	COG1692	metallophosphoesterase
I4W80_08345	COG2359	stage V sporulation protein S
I4W80_08350	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I4W80_08355	COG1063	alcohol dehydrogenase
I4W80_08360	COG0156	8-amino-7-oxononanoate synthase activity
I4W80_08365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I4W80_08370	COG4550	Control of competence regulator ComK, YlbF/YmcA
I4W80_08380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I4W80_08385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I4W80_08405	COG1329	Transcriptional regulator
I4W80_08410	COG4195	phage-related replication protein
I4W80_08415	COG0457	Tetratricopeptide repeat
I4W80_08420	COG1404	Belongs to the peptidase S8 family
I4W80_08425	COG4195	phage-related replication protein
I4W80_08430	COG1764	response to oxidative stress
I4W80_08460	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I4W80_08465	COG1923	regulation of RNA biosynthetic process
I4W80_08480	COG1780	Probably involved in ribonucleotide reductase function
I4W80_08485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I4W80_08490	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I4W80_08495	COG4112	unkown
I4W80_08505	COG0464	growth
I4W80_08510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I4W80_08515	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I4W80_08520	COG0789	Transcriptional regulator
I4W80_08525	COG0174	glutamine synthetase
I4W80_08545	COG0494	nUDIX hydrolase
I4W80_08550	COG0457	Tetratricopeptide repeat
I4W80_08565	COG5444	nuclease activity
I4W80_08590	COG5646	InterPro IPR014922
I4W80_08610	COG0457	Tetratricopeptide repeat
I4W80_08620	COG3619	membrane
I4W80_08625	COG1793	dna ligase
I4W80_08625	COG3285	dna ligase
I4W80_08630	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I4W80_08635	COG4876	unkown
I4W80_08645	COG1959	2 iron, 2 sulfur cluster binding
I4W80_08650	COG0702	epimerase
I4W80_08660	COG0247	lactate metabolic process
I4W80_08665	COG1139	Iron-sulfur cluster binding protein
I4W80_08670	COG1556	Lactate utilization protein
I4W80_08690	COG2323	membrane
I4W80_08695	COG1309	transcriptional regulator
I4W80_08700	COG2124	cytochrome p450
I4W80_08700	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I4W80_08705	COG3591	Belongs to the peptidase S1B family
I4W80_08710	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I4W80_08715	COG3209	COG3209 Rhs family protein
I4W80_08720	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_08735	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I4W80_08740	COG1388	LysM domain
I4W80_08745	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I4W80_08750	COG4224	UPF0291 protein
I4W80_08755	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I4W80_08765	COG3763	UPF0154 protein
I4W80_08775	COG0785	Cytochrome C biogenesis protein
I4W80_08780	COG4846	Membrane protein involved in cytochrome C biogenesis
I4W80_08790	COG0071	Belongs to the small heat shock protein (HSP20) family
I4W80_08805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I4W80_08810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_08830	COG0824	Thioesterase
I4W80_08840	COG4841	protein insertion into membrane
I4W80_08845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I4W80_08850	COG1832	CoA-binding protein
I4W80_08855	COG0187	DNA topoisomerase II activity
I4W80_08860	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I4W80_08870	COG0738	Major facilitator superfamily
I4W80_08875	COG0473	3-isopropylmalate dehydrogenase activity
I4W80_08880	COG0110	maltose O-acetyltransferase activity
I4W80_08885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I4W80_08890	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I4W80_08895	COG0640	Transcriptional regulator
I4W80_08905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I4W80_08910	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I4W80_08920	COG1309	transcriptional regulator
I4W80_08925	COG2249	NAD(P)H dehydrogenase (quinone) activity
I4W80_08930	COG1733	regulation of RNA biosynthetic process
I4W80_08935	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I4W80_08940	COG0251	oxidation-reduction process
I4W80_08965	COG0657	acetylesterase activity
I4W80_08975	COG2723	6-phospho-beta-galactosidase activity
I4W80_08980	COG1263	PTS System
I4W80_08980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_08980	COG2190	(PTS) system
I4W80_08995	COG2205	protein histidine kinase activity
I4W80_09000	COG0745	RESPONSE REGULATOR receiver
I4W80_09010	COG3507	Belongs to the glycosyl hydrolase 43 family
I4W80_09015	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_09020	COG1486	melibiose metabolic process
I4W80_09025	COG0395	ABC-type sugar transport system, permease component
I4W80_09030	COG1175	transmembrane transport
I4W80_09035	COG1653	transport
I4W80_09040	COG1609	Transcriptional regulator
I4W80_09045	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I4W80_09060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_09070	COG0456	acetyltransferase
I4W80_09075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4W80_09090	COG5444	nuclease activity
I4W80_09095	COG1846	Transcriptional regulator
I4W80_09100	COG2814	Major facilitator Superfamily
I4W80_09110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_09110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_09110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_09115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_09115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_09115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4W80_09120	COG1105	Belongs to the carbohydrate kinase PfkB family
I4W80_09130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I4W80_09150	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_09155	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
I4W80_09160	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I4W80_09165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I4W80_09170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I4W80_09175	COG1024	Enoyl-CoA hydratase
I4W80_09180	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I4W80_09185	COG0511	ligase activity, forming carbon-carbon bonds
I4W80_09190	COG0439	Biotin carboxylase
I4W80_09195	COG0318	PFAM AMP-dependent synthetase and ligase
I4W80_09200	COG1960	acyl-CoA dehydrogenase activity
I4W80_09205	COG1649	PFAM Uncharacterised BCR, COG1649
I4W80_09210	COG2365	Tyrosine phosphatase family
I4W80_09215	COG1349	DNA-binding transcription factor activity
I4W80_09220	COG1942	4-Oxalocrotonate Tautomerase
I4W80_09230	COG3835	regulator
I4W80_09235	COG0277	FAD linked oxidase domain protein
I4W80_09240	COG0247	lactate metabolic process
I4W80_09260	COG0166	Belongs to the GPI family
I4W80_09265	COG2246	polysaccharide biosynthetic process
I4W80_09270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I4W80_09275	COG0586	Pfam SNARE associated Golgi protein
I4W80_09280	COG1587	Uroporphyrinogen-III synthase
I4W80_09290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I4W80_09305	COG0534	Mate efflux family protein
I4W80_09310	COG2027	D-alanyl-D-alanine carboxypeptidase
I4W80_09315	COG4677	pectinesterase activity
I4W80_09320	COG2323	membrane
I4W80_09325	COG2146	nitrite reductase [NAD(P)H] activity
I4W80_09330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I4W80_09335	COG0243	molybdopterin cofactor binding
I4W80_09340	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I4W80_09345	COG2223	nitrite transmembrane transporter activity
I4W80_09350	COG0493	'glutamate synthase
I4W80_09355	COG0067	glutamate synthase
I4W80_09355	COG0070	glutamate synthase
I4W80_09355	COG0069	glutamate synthase activity
I4W80_09360	COG0583	DNA-binding transcription factor activity
I4W80_09370	COG1132	(ABC) transporter
I4W80_09375	COG0789	Transcriptional regulator
I4W80_09375	COG4978	Transcriptional regulator
I4W80_09380	COG0454	-acetyltransferase
I4W80_09385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I4W80_09390	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I4W80_09395	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I4W80_09405	COG0243	molybdopterin cofactor binding
I4W80_09415	COG1070	Carbohydrate kinase
I4W80_09420	COG2115	Belongs to the xylose isomerase family
I4W80_09425	COG1940	carbohydrate kinase activity
I4W80_09435	COG2211	Major facilitator Superfamily
I4W80_09440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4W80_09445	COG1994	Peptidase M50
I4W80_09465	COG1309	transcriptional regulator
I4W80_09470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I4W80_09475	COG3708	Transcriptional regulator
I4W80_09480	COG2378	regulation of single-species biofilm formation
I4W80_09490	COG0640	Transcriptional regulator
I4W80_09495	COG0531	amino acid
I4W80_09500	COG0741	lytic transglycosylase activity
I4W80_09505	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I4W80_09510	COG2079	MmgE PrpD family protein
I4W80_09515	COG0372	Belongs to the citrate synthase family
I4W80_09520	COG2322	membrane
I4W80_09530	COG1388	LysM domain
I4W80_09530	COG3584	3D domain protein
I4W80_09535	COG0514	ATP-dependent DNA helicase (RecQ)
I4W80_09545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I4W80_09570	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_09575	COG1657	PFAM Prenyltransferase squalene oxidase
I4W80_09580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I4W80_09585	COG0385	Bile acid
I4W80_09590	COG0508	dehydrogenase complex catalyzes the overall conversion of
I4W80_09595	COG0567	Dehydrogenase, E1 component
I4W80_09600	COG4548	von Willebrand factor, type A
I4W80_09605	COG0714	Associated with various cellular activities
I4W80_09610	COG2032	superoxide dismutase activity
I4W80_09615	COG0791	NLP P60 protein
I4W80_09615	COG1388	LysM domain
I4W80_09620	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I4W80_09625	COG0534	Mate efflux family protein
I4W80_09630	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I4W80_09635	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I4W80_09645	COG2962	Rard protein
I4W80_09660	COG1733	regulation of RNA biosynthetic process
I4W80_09665	COG0778	Nitroreductase
I4W80_09675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I4W80_09680	COG3409	Peptidoglycan-binding domain 1 protein
I4W80_09680	COG0793	Belongs to the peptidase S41A family
I4W80_09685	COG2226	methyltransferase
I4W80_09695	COG1876	peptidase activity
I4W80_09700	COG0813	purine-nucleoside phosphorylase activity
I4W80_09710	COG0671	phosphoesterase, PA-phosphatase related
I4W80_09730	COG4479	Belongs to the UPF0346 family
I4W80_09740	COG1509	lysine 2,3-aminomutase activity
I4W80_09745	COG3829	transcription factor binding
I4W80_09750	COG0463	Glycosyl transferase, family 2
I4W80_09765	COG4641	Protein conserved in bacteria
I4W80_09775	COG1086	Polysaccharide biosynthesis protein
I4W80_09780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I4W80_09785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I4W80_09790	COG1846	Transcriptional regulator
I4W80_09810	COG4698	Protein conserved in bacteria
I4W80_09815	COG2755	lipolytic protein G-D-S-L family
I4W80_09820	COG1999	signal sequence binding
I4W80_09835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I4W80_09840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I4W80_09845	COG1272	protein, Hemolysin III
I4W80_09850	COG0204	Acyl-transferase
I4W80_09855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I4W80_09860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I4W80_09865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I4W80_09875	COG2136	Putative SAM-dependent methyltransferase
I4W80_09875	COG2521	methyltransferase
I4W80_09885	COG0129	dihydroxy-acid dehydratase activity
I4W80_09890	COG1413	lyase activity
I4W80_09895	COG1418	mRNA catabolic process
I4W80_09900	COG0386	Belongs to the glutathione peroxidase family
I4W80_09905	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I4W80_09910	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I4W80_09915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I4W80_09925	COG1278	Cold shock
I4W80_09940	COG0328	RNA-DNA hybrid ribonuclease activity
I4W80_09945	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I4W80_09950	COG0328	RNA-DNA hybrid ribonuclease activity
I4W80_09960	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I4W80_09970	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I4W80_09980	COG1755	Isoprenylcysteine carboxyl methyltransferase
I4W80_09985	COG3424	synthase
I4W80_09990	COG0456	acetyltransferase
I4W80_09990	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I4W80_09995	COG0726	polysaccharide deacetylase
I4W80_10000	COG2233	PERMEase
I4W80_10005	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I4W80_10010	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I4W80_10015	COG1199	ATP-dependent helicase activity
I4W80_10025	COG0116	Belongs to the methyltransferase superfamily
I4W80_10035	COG3599	regulation of cell shape
I4W80_10040	COG4474	Belongs to the UPF0398 family
I4W80_10050	COG3359	exonuclease
I4W80_10055	COG1205	dead DEAH box helicase
I4W80_10055	COG1111	helicase
I4W80_10060	COG1902	pentaerythritol trinitrate reductase activity
I4W80_10065	COG2190	(PTS) system
I4W80_10070	COG0071	Belongs to the small heat shock protein (HSP20) family
I4W80_10100	COG3331	DNA recombination
I4W80_10105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I4W80_10105	COG4499	WXG100 protein secretion system (Wss), protein YukC
I4W80_10115	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I4W80_10120	COG3935	DnaD domain protein
I4W80_10125	COG0017	Asparaginyl-tRNA synthetase
I4W80_10130	COG5353	protein conserved in bacteria
I4W80_10140	COG1199	ATP-dependent helicase activity
I4W80_10140	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I4W80_10145	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I4W80_10150	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I4W80_10155	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I4W80_10165	COG0617	tRNA 3'-terminal CCA addition
I4W80_10170	COG0438	transferase activity, transferring glycosyl groups
I4W80_10175	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I4W80_10180	COG1803	Methylglyoxal synthase
I4W80_10185	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I4W80_10190	COG1694	Mazg nucleotide pyrophosphohydrolase
I4W80_10195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4W80_10205	COG4347	Protein of unknown function (DUF1405)
I4W80_10210	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I4W80_10210	COG2010	Cytochrome c
I4W80_10215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I4W80_10220	COG0723	plastoquinol--plastocyanin reductase activity
I4W80_10230	COG5582	Belongs to the UPF0302 family
I4W80_10235	COG0457	Tetratricopeptide repeat
I4W80_10240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I4W80_10245	COG0287	Prephenate dehydrogenase
I4W80_10250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I4W80_10255	COG0159	tryptophan synthase activity
I4W80_10260	COG0133	tryptophan synthase activity
I4W80_10265	COG0135	phosphoribosylanthranilate isomerase activity
I4W80_10270	COG0134	indole-3-glycerol-phosphate synthase activity
I4W80_10275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I4W80_10285	COG4401	Chorismate mutase type I
I4W80_10290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I4W80_10295	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I4W80_10300	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I4W80_10305	COG0105	UTP biosynthetic process
I4W80_10310	COG0142	geranyltranstransferase activity
I4W80_10315	COG2226	methyltransferase
I4W80_10320	COG0142	geranyltranstransferase activity
I4W80_10330	COG0302	gtp cyclohydrolase
I4W80_10335	COG0776	regulation of translation
I4W80_10340	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I4W80_10355	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I4W80_10360	COG1160	GTP binding
I4W80_10385	COG1304	FMN binding
I4W80_10390	COG0539	negative regulation of cytoplasmic translation
I4W80_10395	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I4W80_10405	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I4W80_10410	COG2959	enzyme of heme biosynthesis
I4W80_10415	COG3773	Cell wall hydrolase
I4W80_10415	COG3409	Peptidoglycan-binding domain 1 protein
I4W80_10420	COG2339	peptidase activity
I4W80_10425	COG0492	ferredoxin-NADP+ reductase activity
I4W80_10430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I4W80_10435	COG4862	establishment of competence for transformation
I4W80_10440	COG1408	metallophosphoesterase
I4W80_10450	COG1388	LysM domain
I4W80_10455	COG1266	CAAX protease self-immunity
I4W80_10460	COG0514	ATP-dependent DNA helicase (RecQ)
I4W80_10465	COG4955	Helix-turn-helix domain
I4W80_10470	COG1141	Ferredoxin
I4W80_10475	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I4W80_10480	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I4W80_10495	COG1595	DNA-templated transcription, initiation
I4W80_10500	COG5002	protein histidine kinase activity
I4W80_10505	COG0745	RESPONSE REGULATOR receiver
I4W80_10510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I4W80_10515	COG1333	cytochrome c biogenesis protein
I4W80_10520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_10525	COG1187	pseudouridine synthase activity
I4W80_10530	COG0700	Nucleoside recognition
I4W80_10535	COG2715	membrane protein required for spore maturation
I4W80_10540	COG1686	Belongs to the peptidase S11 family
I4W80_10550	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I4W80_10555	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I4W80_10565	COG1547	Domain of unknown function (DUF309)
I4W80_10570	COG0456	acetyltransferase
I4W80_10575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I4W80_10580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4W80_10580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4W80_10585	COG0307	riboflavin synthase, alpha
I4W80_10605	COG2814	Major facilitator Superfamily
I4W80_10610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I4W80_10615	COG4086	secreted protein
I4W80_10620	COG0019	diaminopimelate decarboxylase activity
I4W80_10625	COG0697	spore germination
I4W80_10640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I4W80_10660	COG1191	sigma factor activity
I4W80_10665	COG2172	sigma factor antagonist activity
I4W80_10675	COG1686	Belongs to the peptidase S11 family
I4W80_10680	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I4W80_10685	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I4W80_10690	COG4974	Belongs to the 'phage' integrase family
I4W80_10700	COG0735	belongs to the Fur family
I4W80_10705	COG1300	Membrane
I4W80_10710	COG1404	Belongs to the peptidase S8 family
I4W80_10720	COG2153	protein acetylation
I4W80_10725	COG1379	DNA repair
I4W80_10730	COG0494	nUDIX hydrolase
I4W80_10735	COG0667	Aldo Keto reductase
I4W80_10745	COG1073	alpha beta
I4W80_10750	COG0457	Tetratricopeptide repeat
I4W80_10760	COG4918	Iron-sulphur cluster biosynthesis
I4W80_10765	COG4305	rare lipoprotein A
I4W80_10770	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I4W80_10770	COG0456	acetyltransferase
I4W80_10775	COG0456	acetyltransferase
I4W80_10785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I4W80_10795	COG2211	Major facilitator Superfamily
I4W80_10800	COG1072	(Pantothenic acid kinase))
I4W80_10805	COG0446	pyridine nucleotide-disulphide oxidoreductase
I4W80_10815	COG0300	oxidoreductase activity
I4W80_10820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I4W80_10825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I4W80_10835	COG4187	Peptidase family M20/M25/M40
I4W80_10840	COG1902	pentaerythritol trinitrate reductase activity
I4W80_10845	COG0596	Alpha beta hydrolase
I4W80_10850	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4W80_10860	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I4W80_10865	COG2188	Transcriptional regulator
I4W80_10870	COG2723	6-phospho-beta-galactosidase activity
I4W80_10875	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4W80_10880	COG1447	Phosphotransferase system cellobiose-specific component IIA
I4W80_10885	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4W80_10895	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_10905	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I4W80_10910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I4W80_10920	COG0706	membrane insertase activity
I4W80_10925	COG0835	chemotaxis
I4W80_10930	COG2195	Cleaves the N-terminal amino acid of tripeptides
I4W80_10935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I4W80_10940	COG0346	lactoylglutathione lyase activity
I4W80_10950	COG1376	ErfK ybiS ycfS ynhG family protein
I4W80_10955	COG4129	membrane
I4W80_10960	COG1126	abc transporter atp-binding protein
I4W80_10965	COG0765	amino acid transport
I4W80_10970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_10980	COG1597	lipid kinase activity
I4W80_10990	COG0508	dehydrogenase complex catalyzes the overall conversion of
I4W80_10995	COG0022	dehydrogenase e1 component
I4W80_11000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I4W80_11005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I4W80_11010	COG3426	butyrate kinase activity
I4W80_11015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I4W80_11020	COG0280	phosphate acetyltransferase
I4W80_11025	COG3829	transcription factor binding
I4W80_11025	COG3290	protein histidine kinase activity
I4W80_11035	COG0584	glycerophosphoryl diester phosphodiesterase
I4W80_11040	COG0457	Tetratricopeptide repeat
I4W80_11045	COG0745	RESPONSE REGULATOR receiver
I4W80_11050	COG0750	zinc metalloprotease
I4W80_11055	COG0497	DNA recombination
I4W80_11060	COG1438	arginine binding
I4W80_11065	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I4W80_11070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I4W80_11075	COG0142	geranyltranstransferase activity
I4W80_11080	COG1722	exodeoxyribonuclease VII activity
I4W80_11085	COG1570	exodeoxyribonuclease VII activity
I4W80_11090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I4W80_11095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I4W80_11100	COG1302	Protein conserved in bacteria
I4W80_11105	COG0439	Biotin carboxylase
I4W80_11110	COG0511	ligase activity, forming carbon-carbon bonds
I4W80_11150	COG3854	ATPases associated with a variety of cellular activities
I4W80_11160	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I4W80_11165	COG0006	proline dipeptidase activity
I4W80_11170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I4W80_11180	COG3872	metal-dependent enzyme
I4W80_11190	COG1752	Esterase of the alpha-beta hydrolase superfamily
I4W80_11195	COG1321	iron dependent repressor
I4W80_11200	COG0095	Lipoate-protein ligase
I4W80_11205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I4W80_11210	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I4W80_11215	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I4W80_11220	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I4W80_11225	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I4W80_11250	COG0681	Belongs to the peptidase S26 family
I4W80_11285	COG4970	Tfp pilus assembly protein FimT
I4W80_11290	COG4537	Required for transformation and DNA binding
I4W80_11295	COG1459	type II secretion system
I4W80_11300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I4W80_11305	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_11315	COG1393	Belongs to the ArsC family
I4W80_11325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I4W80_11335	COG0011	TIGRFAM Protein of
I4W80_11340	COG2814	Major facilitator Superfamily
I4W80_11345	COG2866	Carboxypeptidase
I4W80_11350	COG1368	sulfuric ester hydrolase activity
I4W80_11355	COG1940	carbohydrate kinase activity
I4W80_11360	COG4483	Protein conserved in bacteria
I4W80_11365	COG0705	Rhomboid family
I4W80_11365	COG0457	Tetratricopeptide repeat
I4W80_11380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I4W80_11385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I4W80_11395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I4W80_11400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I4W80_11405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I4W80_11410	COG0581	inorganic phosphate transmembrane transporter activity
I4W80_11415	COG0573	inorganic phosphate transmembrane transporter activity
I4W80_11420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I4W80_11425	COG0768	penicillin binding
I4W80_11430	COG0477	Major facilitator Superfamily
I4W80_11435	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I4W80_11440	COG2839	Protein conserved in bacteria
I4W80_11445	COG5521	maltodextrose utilization protein MalA
I4W80_11450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I4W80_11455	COG1388	LysM domain
I4W80_11460	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I4W80_11465	COG4709	membrane
I4W80_11470	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I4W80_11475	COG1940	carbohydrate kinase activity
I4W80_11480	COG0735	belongs to the Fur family
I4W80_11485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I4W80_11490	COG1121	(ABC) transporter
I4W80_11495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4W80_11510	COG0513	Belongs to the DEAD box helicase family
I4W80_11520	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I4W80_11525	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I4W80_11530	COG2384	SAM-dependent methyltransferase
I4W80_11535	COG2010	Cytochrome c
I4W80_11540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I4W80_11545	COG0358	DNA primase activity
I4W80_11550	COG1671	Belongs to the UPF0178 family
I4W80_11555	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I4W80_11560	COG0517	IMP dehydrogenase activity
I4W80_11565	COG0751	glycine-tRNA ligase activity
I4W80_11570	COG0752	glycyl-tRNA synthetase alpha subunit
I4W80_11575	COG1381	Involved in DNA repair and RecF pathway recombination
I4W80_11585	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I4W80_11590	COG0295	cytidine deaminase activity
I4W80_11595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I4W80_11600	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I4W80_11605	COG1480	7TM receptor with intracellular HD hydrolase
I4W80_11610	COG1702	phosphate starvation-inducible protein PhoH
I4W80_11615	COG0561	phosphatase activity
I4W80_11630	COG4864	UPF0365 protein
I4W80_11635	COG1030	water channel activity
I4W80_11640	COG1610	YqeY-like protein
I4W80_11650	COG1283	sodium-dependent phosphate transmembrane transporter activity
I4W80_11655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I4W80_11660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I4W80_11665	COG2264	protein methyltransferase activity
I4W80_11670	COG0484	heat shock protein binding
I4W80_11675	COG0443	Heat shock 70 kDa protein
I4W80_11680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I4W80_11685	COG1420	regulation of RNA biosynthetic process
I4W80_11690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I4W80_11695	COG0481	GTPase activity
I4W80_11705	COG0860	N-Acetylmuramoyl-L-alanine amidase
I4W80_11710	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I4W80_11715	COG0268	Binds directly to 16S ribosomal RNA
I4W80_11720	COG1466	dna polymerase III delta subunit
I4W80_11730	COG0658	competence protein
I4W80_11730	COG2333	competence protein COMEC
I4W80_11735	COG2131	deaminase
I4W80_11740	COG1555	photosystem II stabilization
I4W80_11740	COG1596	polysaccharide export
I4W80_11745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I4W80_11750	COG2226	methyltransferase
I4W80_11755	COG0799	negative regulation of ribosome biogenesis
I4W80_11760	COG1713	HD superfamily hydrolase involved in NAD metabolism
I4W80_11765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I4W80_11770	COG1534	Rna-binding protein
I4W80_11775	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I4W80_11780	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I4W80_11785	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I4W80_11800	COG2755	lipolytic protein G-D-S-L family
I4W80_11810	COG0457	Tetratricopeptide repeat
I4W80_11825	COG2186	Transcriptional regulator
I4W80_11840	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_11845	COG3958	Transketolase
I4W80_11850	COG3959	Transketolase, thiamine diphosphate binding domain
I4W80_11870	COG0726	polysaccharide deacetylase
I4W80_11905	COG1122	ATPase activity
I4W80_11930	COG2160	L-arabinose isomerase activity
I4W80_11945	COG1609	Transcriptional regulator
I4W80_11955	COG1846	Transcriptional regulator
I4W80_11965	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I4W80_11970	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I4W80_11975	COG1733	regulation of RNA biosynthetic process
I4W80_11980	COG0657	acetylesterase activity
I4W80_12040	COG2602	Beta-lactamase
I4W80_12045	COG1960	acyl-CoA dehydrogenase activity
I4W80_12050	COG1126	abc transporter atp-binding protein
I4W80_12055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_12060	COG0765	amino acid transport
I4W80_12070	COG3546	catalase activity
I4W80_12075	COG1063	alcohol dehydrogenase
I4W80_12085	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_12095	COG1115	amino acid carrier protein
I4W80_12100	COG0583	DNA-binding transcription factor activity
I4W80_12105	COG1063	alcohol dehydrogenase
I4W80_12110	COG2226	methyltransferase
I4W80_12135	COG0626	cystathionine gamma-synthase activity
I4W80_12140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I4W80_12145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I4W80_12150	COG2226	methyltransferase
I4W80_12165	COG0768	penicillin binding
I4W80_12170	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I4W80_12175	COG0572	uridine kinase
I4W80_12180	COG0826	peptidase U32
I4W80_12185	COG0826	peptidase U32
I4W80_12190	COG4122	O-methyltransferase activity
I4W80_12195	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I4W80_12200	COG0183	Belongs to the thiolase family
I4W80_12205	COG0318	PFAM AMP-dependent synthetase and ligase
I4W80_12210	COG1268	BioY protein
I4W80_12215	COG3906	Belongs to the UPF0473 family
I4W80_12220	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I4W80_12225	COG4472	Bacterial protein of unknown function (DUF965)
I4W80_12230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I4W80_12235	COG0628	permease
I4W80_12240	COG1126	abc transporter atp-binding protein
I4W80_12245	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_12250	COG0765	amino acid transport
I4W80_12255	COG0765	amino acid transport
I4W80_12270	COG3881	PFAM PRC-barrel domain
I4W80_12275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I4W80_12280	COG0457	Tetratricopeptide repeat
I4W80_12285	COG0482	sulfurtransferase activity
I4W80_12290	COG1104	cysteine desulfurase activity
I4W80_12295	COG1959	2 iron, 2 sulfur cluster binding
I4W80_12300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I4W80_12305	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I4W80_12320	COG0124	histidyl-tRNA synthetase
I4W80_12330	COG0860	N-Acetylmuramoyl-L-alanine amidase
I4W80_12330	COG3103	Sh3 type 3 domain protein
I4W80_12330	COG4991	sh3 domain protein
I4W80_12335	COG1490	D-aminoacyl-tRNA deacylase activity
I4W80_12340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I4W80_12345	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I4W80_12350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I4W80_12350	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I4W80_12355	COG5416	Lipopolysaccharide assembly protein A domain
I4W80_12360	COG0490	domain, Protein
I4W80_12365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I4W80_12365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I4W80_12375	COG2244	polysaccharide biosynthetic process
I4W80_12380	COG2323	membrane
I4W80_12390	COG1862	Preprotein translocase
I4W80_12395	COG0343	queuine tRNA-ribosyltransferase activity
I4W80_12400	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I4W80_12410	COG2255	four-way junction helicase activity
I4W80_12415	COG0632	four-way junction helicase activity
I4W80_12425	COG2112	serine threonine protein kinase
I4W80_12440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
I4W80_12455	COG1388	LysM domain
I4W80_12460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
I4W80_12465	COG0157	Belongs to the NadC ModD family
I4W80_12470	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I4W80_12475	COG1104	cysteine desulfurase activity
I4W80_12480	COG1827	regulation of RNA biosynthetic process
I4W80_12485	COG0077	Prephenate dehydratase
I4W80_12490	COG4492	Belongs to the UPF0735 family
I4W80_12495	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I4W80_12500	COG3290	protein histidine kinase activity
I4W80_12505	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I4W80_12510	COG2868	ribosomal protein
I4W80_12515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I4W80_12520	COG1994	Peptidase M50
I4W80_12525	COG0739	heme binding
I4W80_12530	COG2894	cell division
I4W80_12535	COG0850	regulation of cytokinetic process
I4W80_12540	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I4W80_12550	COG1077	Cell shape determining protein MreB Mrl
I4W80_12555	COG2003	Belongs to the UPF0758 family
I4W80_12560	COG0424	maF-like protein
I4W80_12570	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I4W80_12575	COG0285	dihydrofolate synthase activity
I4W80_12580	COG0525	valine-tRNA ligase activity
I4W80_12590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I4W80_12595	COG1388	LysM domain
I4W80_12600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I4W80_12605	COG0113	porphobilinogen synthase activity
I4W80_12610	COG1587	Uroporphyrinogen-III synthase
I4W80_12615	COG0181	hydroxymethylbilane synthase activity
I4W80_12620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I4W80_12625	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I4W80_12635	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I4W80_12640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I4W80_12645	COG1067	ATP-dependent peptidase activity
I4W80_12645	COG0470	DNA polymerase III
I4W80_12650	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I4W80_12655	COG0544	peptidyl-prolyl cis-trans isomerase activity
I4W80_12660	COG1477	protein flavinylation
I4W80_12660	COG0457	Tetratricopeptide repeat
I4W80_12665	COG0066	3-isopropylmalate dehydratase activity
I4W80_12670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I4W80_12675	COG0473	3-isopropylmalate dehydrogenase activity
I4W80_12680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I4W80_12685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I4W80_12690	COG0440	acetolactate synthase activity
I4W80_12695	COG0028	Belongs to the TPP enzyme family
I4W80_12700	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I4W80_12705	COG2706	6-phosphogluconolactonase activity
I4W80_12710	COG3339	Conserved Protein
I4W80_12715	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I4W80_12720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I4W80_12725	COG1696	Membrane protein involved in D-alanine export
I4W80_12730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I4W80_12765	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I4W80_12775	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_12795	COG0622	Phosphoesterase
I4W80_12800	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I4W80_12805	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I4W80_12810	COG5401	PFAM Sporulation and spore germination
I4W80_12815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I4W80_12820	COG1846	Transcriptional regulator
I4W80_12825	COG2197	response regulator
I4W80_12850	COG0860	N-Acetylmuramoyl-L-alanine amidase
I4W80_12855	COG4824	toxin secretion phage lysis holin
I4W80_12880	COG3942	CHAP domain
I4W80_12880	COG1705	Flagellar rod assembly protein muramidase FlgJ
I4W80_12890	COG3953	SLT domain
I4W80_12890	COG5412	phage tail tape measure protein
I4W80_12955	COG1802	Transcriptional regulator
I4W80_12955	COG4626	Terminase
I4W80_12990	COG0582	viral genome integration into host DNA
I4W80_12995	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I4W80_13080	COG2197	response regulator
I4W80_13085	COG2851	Citrate transporter
I4W80_13090	COG0583	DNA-binding transcription factor activity
I4W80_13095	COG2828	Protein conserved in bacteria
I4W80_13105	COG0824	Thioesterase
I4W80_13110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I4W80_13115	COG1053	succinate dehydrogenase
I4W80_13120	COG2009	succinate dehydrogenase
I4W80_13125	COG1719	4-vinyl reductase, 4VR
I4W80_13130	COG0527	aspartate kinase activity
I4W80_13135	COG0322	excinuclease ABC activity
I4W80_13140	COG3118	belongs to the thioredoxin family
I4W80_13145	COG3534	alpha-L-arabinofuranosidase
I4W80_13150	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I4W80_13155	COG2086	electron transfer activity
I4W80_13160	COG1024	Enoyl-CoA hydratase
I4W80_13165	COG1309	transcriptional regulator
I4W80_13170	COG0318	PFAM AMP-dependent synthetase and ligase
I4W80_13180	COG3766	membrane
I4W80_13185	COG1193	negative regulation of DNA recombination
I4W80_13190	COG1796	DNA polymerase
I4W80_13190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I4W80_13195	COG1286	toxin biosynthetic process
I4W80_13200	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I4W80_13205	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I4W80_13210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4W80_13210	COG0072	phenylalanine-tRNA ligase activity
I4W80_13215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I4W80_13220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I4W80_13230	COG1966	Carbon starvation protein
I4W80_13235	COG1363	Peptidase, m42
I4W80_13245	COG3326	Membrane
I4W80_13250	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I4W80_13255	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I4W80_13260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I4W80_13270	COG1011	Hydrolase
I4W80_13280	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I4W80_13290	COG0398	Pfam SNARE associated Golgi protein
I4W80_13295	COG1484	DNA-dependent DNA replication
I4W80_13300	COG3611	Membrane attachment protein
I4W80_13305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I4W80_13315	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I4W80_13320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I4W80_13325	COG0237	dephospho-CoA kinase activity
I4W80_13330	COG1971	Probably functions as a manganese efflux pump
I4W80_13335	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I4W80_13340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I4W80_13340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I4W80_13345	COG5002	protein histidine kinase activity
I4W80_13350	COG0745	RESPONSE REGULATOR receiver
I4W80_13355	COG0039	L-malate dehydrogenase activity
I4W80_13360	COG0538	isocitrate dehydrogenase activity
I4W80_13365	COG0372	Belongs to the citrate synthase family
I4W80_13370	COG2707	UPF0756 membrane protein
I4W80_13375	COG0628	permease
I4W80_13380	COG3030	protein affecting phage T7 exclusion by the F plasmid
I4W80_13390	COG0205	6-phosphofructokinase activity
I4W80_13395	COG0825	malonyl-CoA metabolic process
I4W80_13400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I4W80_13405	COG0281	malic enzyme
I4W80_13410	COG0587	DNA-directed DNA polymerase activity
I4W80_13430	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I4W80_13440	COG4109	DRTGG domain
I4W80_13445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I4W80_13450	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_13460	COG0165	Argininosuccinate lyase
I4W80_13465	COG0137	argininosuccinate synthase activity
I4W80_13470	COG0521	Mo-molybdopterin cofactor biosynthetic process
I4W80_13475	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I4W80_13480	COG0827	DNA restriction-modification system
I4W80_13485	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I4W80_13490	COG3874	Sporulation protein YtfJ
I4W80_13500	COG1714	RDD family
I4W80_13505	COG0616	signal peptide processing
I4W80_13510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I4W80_13520	COG3239	Fatty acid desaturase
I4W80_13525	COG4585	Histidine kinase
I4W80_13530	COG2197	response regulator
I4W80_13535	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I4W80_13540	COG0745	RESPONSE REGULATOR receiver
I4W80_13545	COG2205	protein histidine kinase activity
I4W80_13550	COG0772	Belongs to the SEDS family
I4W80_13555	COG1695	Transcriptional regulator
I4W80_13560	COG1136	(ABC) transporter
I4W80_13565	COG0577	efflux transmembrane transporter activity
I4W80_13570	COG0402	S-adenosylhomocysteine deaminase activity
I4W80_13575	COG2249	NAD(P)H dehydrogenase (quinone) activity
I4W80_13590	COG1279	arginine transmembrane transporter activity
I4W80_13595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I4W80_13605	COG0301	tRNA thio-modification
I4W80_13610	COG1104	cysteine desulfurase activity
I4W80_13615	COG1114	Component of the transport system for branched-chain amino acids
I4W80_13620	COG1114	Component of the transport system for branched-chain amino acids
I4W80_13625	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I4W80_13630	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I4W80_13635	COG1309	transcriptional regulator
I4W80_13640	COG1956	GAF domain-containing protein
I4W80_13645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I4W80_13655	COG1335	isochorismatase
I4W80_13665	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
I4W80_13670	COG2329	Antibiotic biosynthesis monooxygenase
I4W80_13675	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I4W80_13680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I4W80_13685	COG0454	-acetyltransferase
I4W80_13690	COG0517	IMP dehydrogenase activity
I4W80_13695	COG0123	including yeast histone deacetylase and acetoin utilization protein
I4W80_13700	COG1609	Transcriptional regulator
I4W80_13705	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I4W80_13705	COG1605	Chorismate mutase
I4W80_13710	COG3118	belongs to the thioredoxin family
I4W80_13715	COG4980	gas vesicle protein
I4W80_13720	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I4W80_13725	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I4W80_13730	COG1674	ftsk spoiiie
I4W80_13735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4W80_13740	COG4848	Belongs to the UPF0354 family
I4W80_13745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_13760	COG1363	Peptidase, m42
I4W80_13765	COG5584	Small secreted protein
I4W80_13770	COG0281	malic enzyme
I4W80_13775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I4W80_13780	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I4W80_13790	COG0510	thiamine kinase activity
I4W80_13795	COG1597	lipid kinase activity
I4W80_13805	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I4W80_13810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I4W80_13815	COG3340	Belongs to the peptidase S51 family
I4W80_13820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I4W80_13825	COG2252	PERMEase
I4W80_13830	COG1349	DNA-binding transcription factor activity
I4W80_13835	COG1187	pseudouridine synthase activity
I4W80_13840	COG2244	polysaccharide biosynthetic process
I4W80_13845	COG2081	HI0933 family
I4W80_13855	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I4W80_13860	COG3196	Protein conserved in bacteria
I4W80_13870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I4W80_13875	COG5578	integral membrane protein
I4W80_13880	COG0673	inositol 2-dehydrogenase activity
I4W80_13885	COG1653	transport
I4W80_13890	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I4W80_13895	COG4209	transmembrane transport
I4W80_13900	COG2207	Transcriptional regulator
I4W80_13905	COG1733	regulation of RNA biosynthetic process
I4W80_13910	COG2814	Major facilitator Superfamily
I4W80_13915	COG0656	L-ascorbic acid biosynthetic process
I4W80_13920	COG1653	transport
I4W80_13925	COG0395	ABC-type sugar transport system, permease component
I4W80_13930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I4W80_13935	COG1073	alpha beta
I4W80_13940	COG0495	leucyl-tRNA aminoacylation
I4W80_13950	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_13950	COG2202	Pas domain
I4W80_13955	COG2433	Pfam Transposase IS66
I4W80_13960	COG0577	efflux transmembrane transporter activity
I4W80_13965	COG1136	(ABC) transporter
I4W80_13975	COG1131	(ABC) transporter
I4W80_13980	COG1725	Transcriptional regulator
I4W80_14000	COG1242	4 iron, 4 sulfur cluster binding
I4W80_14005	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I4W80_14010	COG4326	sporulation control protein
I4W80_14020	COG2267	carboxylic ester hydrolase activity
I4W80_14025	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I4W80_14030	COG0367	asparagine synthase
I4W80_14035	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I4W80_14040	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
I4W80_14050	COG1506	peptidase
I4W80_14055	COG1233	COG1233 Phytoene dehydrogenase and related
I4W80_14075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I4W80_14080	COG1116	anion transmembrane transporter activity
I4W80_14085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I4W80_14090	COG0494	nUDIX hydrolase
I4W80_14095	COG2310	stress, protein
I4W80_14110	COG4824	toxin secretion phage lysis holin
I4W80_14120	COG0783	Belongs to the Dps family
I4W80_14135	COG1854	S-ribosylhomocysteine lyase activity
I4W80_14140	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I4W80_14145	COG0288	reversible hydration of carbon dioxide
I4W80_14150	COG3443	Belongs to the bacterial solute-binding protein 9 family
I4W80_14150	COG0803	Belongs to the bacterial solute-binding protein 9 family
I4W80_14160	COG1271	oxidase subunit
I4W80_14165	COG1294	oxidase, subunit
I4W80_14180	COG4948	Mandelate Racemase Muconate Lactonizing
I4W80_14185	COG0318	PFAM AMP-dependent synthetase and ligase
I4W80_14190	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I4W80_14195	COG0596	Alpha beta hydrolase
I4W80_14200	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I4W80_14205	COG1169	isochorismate synthase
I4W80_14210	COG1575	Belongs to the MenA family. Type 1 subfamily
I4W80_14215	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I4W80_14345	COG3859	Proton-coupled thiamine transporter YuaJ
I4W80_14350	COG1247	-acetyltransferase
I4W80_14355	COG3339	Conserved Protein
I4W80_14360	COG0772	Belongs to the SEDS family
I4W80_14365	COG0772	Belongs to the SEDS family
I4W80_14370	COG2268	Band 7 protein
I4W80_14375	COG1585	Membrane protein implicated in regulation of membrane protease activity
I4W80_14380	COG2318	DinB family
I4W80_14385	COG1454	alcohol dehydrogenase
I4W80_14390	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_14395	COG1510	regulation of RNA biosynthetic process
I4W80_14410	COG5632	N-Acetylmuramoyl-L-alanine amidase
I4W80_14410	COG3409	Peptidoglycan-binding domain 1 protein
I4W80_14465	COG3778	Protein conserved in bacteria
I4W80_14470	COG3299	homolog of phage Mu protein gp47
I4W80_14475	COG3628	GPW Gp25 family protein
I4W80_14485	COG4193	domain, Protein
I4W80_14490	COG1652	LysM domain
I4W80_14495	COG3953	SLT domain
I4W80_14495	COG5280	Phage tail tape measure protein TP901
I4W80_14495	COG3953	SLT domain
I4W80_14495	COG5280	Phage tail tape measure protein TP901
I4W80_14550	COG4653	Phage capsid family
I4W80_14555	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I4W80_14560	COG5518	Phage portal protein
I4W80_14565	COG1783	phage Terminase large subunit
I4W80_14570	COG5484	DNA packaging
I4W80_14575	COG1595	DNA-templated transcription, initiation
I4W80_14585	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I4W80_14605	COG1396	sequence-specific DNA binding
I4W80_14615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I4W80_14630	COG0628	permease
I4W80_14640	COG0673	inositol 2-dehydrogenase activity
I4W80_14645	COG0693	protein deglycase activity
I4W80_14650	COG0840	transmembrane signaling receptor activity
I4W80_14655	COG0840	transmembrane signaling receptor activity
I4W80_14660	COG0840	transmembrane signaling receptor activity
I4W80_14665	COG0840	transmembrane signaling receptor activity
I4W80_14680	COG2070	2-Nitropropane dioxygenase
I4W80_14685	COG0432	Pfam Uncharacterised protein family UPF0047
I4W80_14690	COG1253	flavin adenine dinucleotide binding
I4W80_14695	COG2738	Putative neutral zinc metallopeptidase
I4W80_14705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I4W80_14720	COG0166	Belongs to the GPI family
I4W80_14725	COG1979	alcohol dehydrogenase
I4W80_14730	COG1979	alcohol dehydrogenase
I4W80_14735	COG2155	Conserved Protein
I4W80_14740	COG1098	S1 RNA binding domain
I4W80_14745	COG0436	Aminotransferase
I4W80_14750	COG1522	sequence-specific DNA binding
I4W80_14755	COG2267	carboxylic ester hydrolase activity
I4W80_14765	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I4W80_14770	COG2205	protein histidine kinase activity
I4W80_14785	COG5018	Exonuclease
I4W80_14790	COG2814	Major facilitator Superfamily
I4W80_14795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I4W80_14800	COG3011	Protein conserved in bacteria
I4W80_14810	COG3290	protein histidine kinase activity
I4W80_14815	COG4565	transcriptional regulatory protein
I4W80_14820	COG1744	ABC transporter substrate-binding protein PnrA-like
I4W80_14825	COG3845	ABC transporter
I4W80_14830	COG4603	Belongs to the binding-protein-dependent transport system permease family
I4W80_14835	COG1079	Belongs to the binding-protein-dependent transport system permease family
I4W80_14840	COG3493	citrate carrier protein
I4W80_14850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I4W80_14850	COG2111	Na H antiporter
I4W80_14855	COG2111	Na H antiporter
I4W80_14860	COG1006	Multisubunit Na H antiporter MnhC subunit
I4W80_14865	COG0651	ATP synthesis coupled electron transport
I4W80_14870	COG1863	multisubunit Na H antiporter MnhE subunit
I4W80_14875	COG2212	antiporter activity
I4W80_14880	COG1320	monovalent cation:proton antiporter activity
I4W80_14885	COG2050	protein possibly involved in aromatic compounds catabolism
I4W80_14890	COG2197	response regulator
I4W80_14895	COG4585	Histidine kinase
I4W80_14905	COG0142	geranyltranstransferase activity
I4W80_14920	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I4W80_14925	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I4W80_14930	COG1335	isochorismatase
I4W80_14935	COG5506	Protein of unknown function (DUF1694)
I4W80_14955	COG0628	permease
I4W80_14970	COG1418	mRNA catabolic process
I4W80_14975	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_14985	COG1511	domain protein
I4W80_14990	COG0433	COG0433 Predicted ATPase
I4W80_14990	COG1674	ftsk spoiiie
I4W80_14995	COG4499	WXG100 protein secretion system (Wss), protein YukC
I4W80_15000	COG5417	Belongs to the EsaB family
I4W80_15005	COG4842	Belongs to the WXG100 family
I4W80_15010	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I4W80_15010	COG2508	Transcriptional regulator
I4W80_15015	COG0686	Belongs to the AlaDH PNT family
I4W80_15020	COG1268	BioY protein
I4W80_15025	COG2056	Na+-H+ antiporter family
I4W80_15030	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I4W80_15035	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I4W80_15040	COG3584	3D domain protein
I4W80_15055	COG1252	NADH dehydrogenase
I4W80_15060	COG0492	ferredoxin-NADP+ reductase activity
I4W80_15075	COG0316	Belongs to the HesB IscA family
I4W80_15080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I4W80_15085	COG4844	belongs to the
I4W80_15090	COG1252	NADH dehydrogenase
I4W80_15100	COG4837	Protein of unknown function (DUF1462)
I4W80_15105	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I4W80_15110	COG1506	peptidase
I4W80_15110	COG0823	Involved in the tonB-independent uptake of proteins
I4W80_15110	COG4946	Tricorn protease homolog
I4W80_15115	COG0083	homoserine kinase activity
I4W80_15120	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I4W80_15125	COG0460	homoserine dehydrogenase
I4W80_15130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I4W80_15135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I4W80_15140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I4W80_15145	COG0647	UMP catabolic process
I4W80_15150	COG2445	Protein of unknown function DUF86
I4W80_15155	COG4470	Protein conserved in bacteria
I4W80_15165	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I4W80_15170	COG0739	heme binding
I4W80_15190	COG3377	Domain of unknown function (DUF1805)
I4W80_15195	COG0737	Belongs to the 5'-nucleotidase family
I4W80_15200	COG1801	Protein of unknown function DUF72
I4W80_15205	COG2508	Transcriptional regulator
I4W80_15215	COG2814	Major facilitator Superfamily
I4W80_15220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I4W80_15225	COG2356	endonuclease I
I4W80_15240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_15245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_15250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I4W80_15270	COG0642	Histidine kinase
I4W80_15270	COG5002	protein histidine kinase activity
I4W80_15275	COG0745	RESPONSE REGULATOR receiver
I4W80_15280	COG2311	Membrane
I4W80_15290	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I4W80_15295	COG1090	epimerase
I4W80_15300	COG1309	transcriptional regulator
I4W80_15310	COG0719	Fe-S assembly protein
I4W80_15315	COG0822	iron-sulfur transferase activity
I4W80_15320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I4W80_15325	COG0719	Fe-S assembly protein
I4W80_15330	COG0396	ATPase activity
I4W80_15340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I4W80_15345	COG1464	Belongs to the NlpA lipoprotein family
I4W80_15350	COG2011	ABC-type metal ion transport system permease component
I4W80_15355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I4W80_15365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4W80_15370	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I4W80_15380	COG0509	glycine decarboxylation via glycine cleavage system
I4W80_15385	COG1393	Belongs to the ArsC family
I4W80_15390	COG1960	acyl-CoA dehydrogenase activity
I4W80_15395	COG0183	Belongs to the thiolase family
I4W80_15400	COG1024	Enoyl-CoA hydratase
I4W80_15400	COG1250	3-hydroxyacyl-CoA dehydrogenase
I4W80_15415	COG5577	PFAM Coat F domain
I4W80_15425	COG1120	ATPase activity
I4W80_15435	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_15440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I4W80_15445	COG0745	RESPONSE REGULATOR receiver
I4W80_15450	COG2205	protein histidine kinase activity
I4W80_15450	COG2770	Histidine kinase
I4W80_15460	COG1309	transcriptional regulator
I4W80_15465	COG0114	fumarate hydratase activity
I4W80_15475	COG0697	spore germination
I4W80_15480	COG0814	amino acid
I4W80_15495	COG2197	response regulator
I4W80_15500	COG4585	Histidine kinase
I4W80_15505	COG4758	membrane
I4W80_15515	COG1842	Phage shock protein A
I4W80_15520	COG4758	membrane
I4W80_15525	COG2096	Adenosyltransferase
I4W80_15530	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_15535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I4W80_15545	COG3604	Transcriptional regulator
I4W80_15560	COG1454	alcohol dehydrogenase
I4W80_15565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I4W80_15570	COG1120	ATPase activity
I4W80_15575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_15580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I4W80_15590	COG2721	sulfolactate sulfo-lyase activity
I4W80_15595	COG0246	Mannitol dehydrogenase
I4W80_15600	COG1609	Transcriptional regulator
I4W80_15605	COG1904	glucuronate isomerase
I4W80_15610	COG2205	protein histidine kinase activity
I4W80_15615	COG0745	RESPONSE REGULATOR receiver
I4W80_15620	COG1120	ATPase activity
I4W80_15625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_15630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_15635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I4W80_15640	COG0531	amino acid
I4W80_15655	COG1988	membrane-bound metal-dependent
I4W80_15660	COG1368	sulfuric ester hydrolase activity
I4W80_15665	COG0725	ABC transporter, periplasmic molybdate-binding protein
I4W80_15670	COG4149	molybdate abc transporter
I4W80_15675	COG0656	L-ascorbic acid biosynthetic process
I4W80_15680	COG1940	carbohydrate kinase activity
I4W80_15685	COG0025	NhaP-type Na H and K H
I4W80_15690	COG2860	membrane
I4W80_15695	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I4W80_15700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I4W80_15705	COG2217	Heavy metal translocating P-type atpase
I4W80_15710	COG1121	(ABC) transporter
I4W80_15715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I4W80_15720	COG0803	Belongs to the bacterial solute-binding protein 9 family
I4W80_15730	COG3226	Transcriptional regulator
I4W80_15735	COG0784	Response regulator, receiver
I4W80_15740	COG4191	Histidine kinase
I4W80_15745	COG1027	Aspartate ammonia-lyase
I4W80_15755	COG2217	Heavy metal translocating P-type atpase
I4W80_15760	COG2608	mercury ion transmembrane transporter activity
I4W80_15765	COG1937	Protein conserved in bacteria
I4W80_15800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I4W80_15805	COG0557	exoribonuclease II activity
I4W80_15810	COG1647	Serine aminopeptidase, S33
I4W80_15815	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I4W80_15820	COG2002	toxin-antitoxin pair type II binding
I4W80_15825	COG1476	TRANSCRIPTIONal
I4W80_15830	COG1396	sequence-specific DNA binding
I4W80_15835	COG1396	sequence-specific DNA binding
I4W80_15840	COG1733	regulation of RNA biosynthetic process
I4W80_15845	COG1174	glycine betaine transport
I4W80_15850	COG1732	Glycine betaine
I4W80_15855	COG1174	glycine betaine transport
I4W80_15860	COG0517	IMP dehydrogenase activity
I4W80_15860	COG1125	glycine betaine transport
I4W80_15865	COG1510	regulation of RNA biosynthetic process
I4W80_15870	COG2095	MarC family integral membrane protein
I4W80_15880	COG0456	acetyltransferase
I4W80_15900	COG1131	(ABC) transporter
I4W80_15910	COG0148	phosphopyruvate hydratase activity
I4W80_15915	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I4W80_15920	COG0149	triose-phosphate isomerase activity
I4W80_15925	COG0126	phosphoglycerate kinase activity
I4W80_15930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I4W80_15935	COG2390	Transcriptional regulator
I4W80_15940	COG0833	amino acid
I4W80_15945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I4W80_15950	COG3829	transcription factor binding
I4W80_15955	COG2186	Transcriptional regulator
I4W80_15960	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I4W80_15970	COG0534	Mate efflux family protein
I4W80_15975	COG4608	Belongs to the ABC transporter superfamily
I4W80_15980	COG0444	Belongs to the ABC transporter superfamily
I4W80_15985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4W80_15990	COG0601	transmembrane transport
I4W80_15995	COG0747	negative chemotaxis
I4W80_16000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I4W80_16005	COG0110	maltose O-acetyltransferase activity
I4W80_16010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I4W80_16015	COG2244	polysaccharide biosynthetic process
I4W80_16020	COG5039	Polysaccharide pyruvyl transferase
I4W80_16025	COG1216	Glycosyl transferase, family 2
I4W80_16035	COG0438	transferase activity, transferring glycosyl groups
I4W80_16040	COG1215	transferase activity, transferring glycosyl groups
I4W80_16045	COG0438	transferase activity, transferring glycosyl groups
I4W80_16050	COG1086	Polysaccharide biosynthesis protein
I4W80_16055	COG0489	protein tyrosine kinase activity
I4W80_16060	COG3944	biosynthesis protein
I4W80_16065	COG1396	sequence-specific DNA binding
I4W80_16075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I4W80_16080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_16085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_16090	COG0726	polysaccharide deacetylase
I4W80_16095	COG0488	(ABC) transporter
I4W80_16115	COG0601	transmembrane transport
I4W80_16120	COG0747	negative chemotaxis
I4W80_16125	COG1819	glycosyl
I4W80_16140	COG0740	serine-type endopeptidase activity
I4W80_16145	COG1611	Belongs to the LOG family
I4W80_16150	COG1694	Mazg nucleotide pyrophosphohydrolase
I4W80_16155	COG0659	secondary active sulfate transmembrane transporter activity
I4W80_16160	COG0288	reversible hydration of carbon dioxide
I4W80_16165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I4W80_16175	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I4W80_16180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_16185	COG1481	regulation of sporulation
I4W80_16190	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I4W80_16195	COG1660	Displays ATPase and GTPase activities
I4W80_16200	COG1051	belongs to the nudix hydrolase family
I4W80_16205	COG0492	ferredoxin-NADP+ reductase activity
I4W80_16210	COG3883	PFAM NLP P60 protein
I4W80_16210	COG0791	NLP P60 protein
I4W80_16215	COG0457	Tetratricopeptide repeat
I4W80_16220	COG0140	phosphoribosyl-ATP diphosphatase activity
I4W80_16220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I4W80_16225	COG0107	imidazoleglycerol-phosphate synthase activity
I4W80_16230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I4W80_16235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I4W80_16240	COG0131	Imidazoleglycerol-phosphate dehydratase
I4W80_16245	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I4W80_16250	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I4W80_16255	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
I4W80_16260	COG4990	cell redox homeostasis
I4W80_16265	COG2910	NAD(P)H-binding
I4W80_16270	COG1959	2 iron, 2 sulfur cluster binding
I4W80_16275	COG0110	maltose O-acetyltransferase activity
I4W80_16280	COG0546	phosphoglycolate phosphatase activity
I4W80_16285	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I4W80_16295	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I4W80_16300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I4W80_16305	COG0363	glucosamine-6-phosphate deaminase activity
I4W80_16310	COG2188	Transcriptional regulator
I4W80_16315	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I4W80_16320	COG1950	PFAM Membrane protein of
I4W80_16325	COG1983	PspC domain protein
I4W80_16330	COG3595	metallopeptidase activity
I4W80_16345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I4W80_16355	COG4897	Protein conserved in bacteria
I4W80_16360	COG0574	Belongs to the PEP-utilizing enzyme family
I4W80_16360	COG3848	Pyruvate phosphate dikinase
I4W80_16365	COG1309	transcriptional regulator
I4W80_16370	COG2814	Major facilitator Superfamily
I4W80_16380	COG0745	RESPONSE REGULATOR receiver
I4W80_16385	COG5002	protein histidine kinase activity
I4W80_16390	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I4W80_16395	COG0463	Glycosyl transferase, family 2
I4W80_16400	COG1113	amino acid transport
I4W80_16405	COG0778	Nitroreductase
I4W80_16410	COG1733	regulation of RNA biosynthetic process
I4W80_16415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I4W80_16425	COG3409	Peptidoglycan-binding domain 1 protein
I4W80_16425	COG0793	Belongs to the peptidase S41A family
I4W80_16430	COG0730	response to heat
I4W80_16435	COG0791	NLP P60 protein
I4W80_16435	COG3883	PFAM NLP P60 protein
I4W80_16440	COG2177	Part of the ABC transporter FtsEX involved in
I4W80_16445	COG2884	Cell division ATP-binding protein ftsE
I4W80_16450	COG2010	Cytochrome c
I4W80_16455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4W80_16475	COG0653	protein targeting
I4W80_16480	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I4W80_16485	COG0840	transmembrane signaling receptor activity
I4W80_16500	COG1516	flagellar protein fliS
I4W80_16505	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I4W80_16510	COG1334	flagellar protein FlaG
I4W80_16515	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I4W80_16520	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
I4W80_16530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I4W80_16535	COG4786	Flagellar basal body rod
I4W80_16535	COG1256	bacterial-type flagellum assembly
I4W80_16540	COG3418	PFAM FlgN family protein
I4W80_16555	COG1040	competence protein
I4W80_16565	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I4W80_16570	COG1307	EDD domain protein, DegV family
I4W80_16575	COG2197	response regulator
I4W80_16580	COG4585	Histidine kinase
I4W80_16585	COG1739	Uncharacterized protein family UPF0029
I4W80_16590	COG1316	TRANSCRIPTIONal
I4W80_16595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I4W80_16600	COG0438	transferase activity, transferring glycosyl groups
I4W80_16605	COG1215	transferase activity, transferring glycosyl groups
I4W80_16610	COG3206	protein involved in exopolysaccharide biosynthesis
I4W80_16615	COG3307	-O-antigen
I4W80_16620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I4W80_16625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I4W80_16630	COG0438	transferase activity, transferring glycosyl groups
I4W80_16630	COG0297	glycogen (starch) synthase activity
I4W80_16635	COG2244	polysaccharide biosynthetic process
I4W80_16650	COG0860	N-Acetylmuramoyl-L-alanine amidase
I4W80_16650	COG2247	cell wall binding repeat
I4W80_16655	COG0860	N-Acetylmuramoyl-L-alanine amidase
I4W80_16655	COG2247	cell wall binding repeat
I4W80_16660	COG2247	cell wall binding repeat
I4W80_16660	COG2385	sporulation resulting in formation of a cellular spore
I4W80_16670	COG1316	TRANSCRIPTIONal
I4W80_16675	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I4W80_16680	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I4W80_16685	COG1134	teichoic acid transport
I4W80_16690	COG1682	transport, permease protein
I4W80_16700	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I4W80_16710	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I4W80_16715	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I4W80_16720	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I4W80_16725	COG4193	domain, Protein
I4W80_16730	COG1482	cell wall glycoprotein biosynthetic process
I4W80_16740	COG1175	transmembrane transport
I4W80_16745	COG1653	transport
I4W80_16750	COG2197	response regulator
I4W80_16755	COG2972	Histidine kinase
I4W80_16765	COG0454	-acetyltransferase
I4W80_16770	COG0800	Aldolase
I4W80_16775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I4W80_16780	COG1609	Transcriptional regulator
I4W80_16785	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I4W80_16790	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_16795	COG0697	spore germination
I4W80_16800	COG0814	amino acid
I4W80_16815	COG2814	Major facilitator Superfamily
I4W80_16820	COG1316	TRANSCRIPTIONal
I4W80_16825	COG0561	phosphatase activity
I4W80_16830	COG0791	NLP P60 protein
I4W80_16840	COG2843	Capsule synthesis protein
I4W80_16850	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I4W80_16855	COG0697	spore germination
I4W80_16870	COG1609	Transcriptional regulator
I4W80_16875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I4W80_16880	COG1869	D-ribose catabolic process
I4W80_16885	COG1129	ABC transporter
I4W80_16890	COG1172	Belongs to the binding-protein-dependent transport system permease family
I4W80_16895	COG1879	ABC-type sugar transport system periplasmic component
I4W80_16900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I4W80_16905	COG0583	DNA-binding transcription factor activity
I4W80_16910	COG0028	Belongs to the TPP enzyme family
I4W80_16915	COG3527	Alpha-acetolactate decarboxylase
I4W80_16920	COG1522	sequence-specific DNA binding
I4W80_16925	COG2059	Chromate
I4W80_16930	COG2059	Chromate
I4W80_16935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I4W80_16945	COG4715	Zinc finger, swim domain protein
I4W80_16950	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I4W80_16955	COG1366	Belongs to the anti-sigma-factor antagonist family
I4W80_16955	COG2202	Pas domain
I4W80_16960	COG0561	phosphatase activity
I4W80_16975	COG1970	mechanosensitive ion channel activity
I4W80_16980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I4W80_16985	COG0457	Tetratricopeptide repeat
I4W80_16990	COG4786	Flagellar basal body rod
I4W80_16995	COG4786	Flagellar basal body rod
I4W80_17000	COG1077	Cell shape determining protein MreB Mrl
I4W80_17005	COG1609	Transcriptional regulator
I4W80_17010	COG1846	Transcriptional regulator
I4W80_17015	COG2814	Major facilitator Superfamily
I4W80_17020	COG0671	phosphoesterase, PA-phosphatase related
I4W80_17025	COG0477	Major facilitator Superfamily
I4W80_17030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_17035	COG0765	amino acid transport
I4W80_17040	COG1126	abc transporter atp-binding protein
I4W80_17045	COG0004	ammonium transporteR
I4W80_17050	COG0347	Belongs to the P(II) protein family
I4W80_17055	COG0739	heme binding
I4W80_17060	COG1247	-acetyltransferase
I4W80_17100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I4W80_17105	COG0523	cobalamin synthesis protein
I4W80_17110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I4W80_17115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I4W80_17120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I4W80_17125	COG2223	nitrite transmembrane transporter activity
I4W80_17135	COG2304	oxidoreductase activity
I4W80_17140	COG2304	oxidoreductase activity
I4W80_17145	COG2385	sporulation resulting in formation of a cellular spore
I4W80_17150	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I4W80_17160	COG4836	Membrane
I4W80_17170	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I4W80_17175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I4W80_17180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I4W80_17185	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I4W80_17190	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I4W80_17195	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I4W80_17200	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I4W80_17205	COG0356	it plays a direct role in the translocation of protons across the membrane
I4W80_17215	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I4W80_17220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I4W80_17225	COG4475	Protein of unknown function (DUF436)
I4W80_17230	COG0698	ribose 5-phosphate isomerase
I4W80_17235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I4W80_17240	COG1971	Probably functions as a manganese efflux pump
I4W80_17245	COG0009	L-threonylcarbamoyladenylate synthase
I4W80_17250	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I4W80_17265	COG2890	protein-(glutamine-N5) methyltransferase activity
I4W80_17270	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I4W80_17275	COG0789	Transcriptional regulator
I4W80_17280	COG0679	Auxin Efflux Carrier
I4W80_17285	COG0281	malic enzyme
I4W80_17290	COG1435	thymidine kinase activity
I4W80_17295	COG0254	rRNA binding
I4W80_17300	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I4W80_17305	COG1494	fructose-1,6-bisphosphatase
I4W80_17310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I4W80_17315	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I4W80_17320	COG0191	fructose-bisphosphate aldolase activity
I4W80_17325	COG2204	response regulator
I4W80_17330	COG4821	SIS domain
I4W80_17335	COG0504	CTP synthase activity
I4W80_17340	COG3343	RNA polymerase activity
I4W80_17355	COG1960	acyl-CoA dehydrogenase activity
I4W80_17360	COG1960	acyl-CoA dehydrogenase activity
I4W80_17365	COG1250	3-hydroxyacyl-CoA dehydrogenase
I4W80_17370	COG0183	Belongs to the thiolase family
I4W80_17375	COG0247	lactate metabolic process
I4W80_17375	COG2181	nitrate reductase activity
I4W80_17380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I4W80_17385	COG4294	response to UV
I4W80_17395	COG1619	proteins homologs of microcin C7 resistance protein MccF
I4W80_17405	COG1132	(ABC) transporter
I4W80_17410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I4W80_17420	COG0018	arginyl-trna synthetase
I4W80_17425	COG4506	Protein conserved in bacteria
I4W80_17435	COG0010	Belongs to the arginase family
I4W80_17440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I4W80_17445	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I4W80_17455	COG1994	Peptidase M50
I4W80_17460	COG1942	4-Oxalocrotonate Tautomerase
I4W80_17470	COG3465	dGTPase activity
I4W80_17475	COG1078	dGTPase activity
I4W80_17480	COG4844	belongs to the
I4W80_17530	COG5444	nuclease activity
I4W80_17560	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I4W80_17570	COG0280	phosphate acetyltransferase
I4W80_17580	COG2814	Major facilitator Superfamily
I4W80_17585	COG1522	sequence-specific DNA binding
I4W80_17590	COG2814	Major facilitator Superfamily
I4W80_17595	COG0077	Prephenate dehydratase
I4W80_17600	COG1917	Cupin 2, conserved barrel domain protein
I4W80_17605	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_17610	COG0151	Belongs to the GarS family
I4W80_17615	COG0436	Aminotransferase
I4W80_17620	COG1028	Short-chain dehydrogenase reductase Sdr
I4W80_17625	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I4W80_17630	COG1091	dTDP-4-dehydrorhamnose reductase activity
I4W80_17635	COG1088	dTDP-glucose 4,6-dehydratase activity
I4W80_17640	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I4W80_17645	COG3980	spore coat polysaccharide biosynthesis protein
I4W80_17650	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
I4W80_17655	COG2089	acid synthase
I4W80_17660	COG0456	acetyltransferase
I4W80_17665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I4W80_17670	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I4W80_17675	COG0463	Glycosyl transferase, family 2
I4W80_17695	COG2363	Small membrane protein
I4W80_17700	COG2233	PERMEase
I4W80_17710	COG1012	belongs to the aldehyde dehydrogenase family
I4W80_17715	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I4W80_17720	COG1216	Glycosyl transferase, family 2
I4W80_17730	COG0351	phosphomethylpyrimidine kinase
I4W80_17745	COG1621	beta-fructofuranosidase activity
I4W80_17750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_17750	COG1263	PTS System
I4W80_17755	COG3711	transcriptional antiterminator
I4W80_17765	COG1404	Belongs to the peptidase S8 family
I4W80_17775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I4W80_17780	COG0778	Nitroreductase
I4W80_17785	COG0772	Belongs to the SEDS family
I4W80_17795	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I4W80_17800	COG1845	cytochrome c oxidase, subunit III
I4W80_17805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I4W80_17810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I4W80_17820	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I4W80_17825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I4W80_17830	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I4W80_17845	COG2246	polysaccharide biosynthetic process
I4W80_17865	COG3162	membrane
I4W80_17870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I4W80_17885	COG0352	thiamine-phosphate diphosphorylase activity
I4W80_17890	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I4W80_17895	COG0583	DNA-binding transcription factor activity
I4W80_17900	COG1380	Effector of murein hydrolase LrgA
I4W80_17905	COG1346	cytolysis
I4W80_17910	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I4W80_17915	COG0346	lactoylglutathione lyase activity
I4W80_17925	COG0765	amino acid transport
I4W80_17930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4W80_17935	COG0457	Tetratricopeptide repeat
I4W80_17945	COG2357	RelA SpoT domain protein
I4W80_17950	COG1172	Belongs to the binding-protein-dependent transport system permease family
I4W80_17955	COG1129	ABC transporter
I4W80_17965	COG3420	alginic acid biosynthetic process
I4W80_17970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I4W80_17980	COG1486	melibiose metabolic process
I4W80_17985	COG1447	Phosphotransferase system cellobiose-specific component IIA
I4W80_17990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4W80_17995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4W80_18000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_18000	COG3711	transcriptional antiterminator
I4W80_18015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I4W80_18030	COG1595	DNA-templated transcription, initiation
I4W80_18040	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I4W80_18045	COG4988	ABC transporter
I4W80_18050	COG1294	oxidase, subunit
I4W80_18055	COG1271	oxidase subunit
I4W80_18060	COG1120	ATPase activity
I4W80_18065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4W80_18070	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I4W80_18075	COG4509	Sortase family
I4W80_18100	COG5386	Cell surface protein
I4W80_18105	COG5386	Cell surface protein
I4W80_18110	COG1733	regulation of RNA biosynthetic process
I4W80_18115	COG2514	catechol 2,3-dioxygenase activity
I4W80_18120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4W80_18120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4W80_18125	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I4W80_18125	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I4W80_18135	COG0726	polysaccharide deacetylase
I4W80_18140	COG1447	Phosphotransferase system cellobiose-specific component IIA
I4W80_18145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4W80_18150	COG2723	6-phospho-beta-galactosidase activity
I4W80_18155	COG1312	Catalyzes the dehydration of D-mannonate
I4W80_18160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4W80_18165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4W80_18165	COG3711	transcriptional antiterminator
I4W80_18190	COG1757	Na H antiporter
I4W80_18195	COG1027	Aspartate ammonia-lyase
I4W80_18200	COG0252	asparaginase activity
I4W80_18205	COG1396	sequence-specific DNA binding
I4W80_18230	COG4842	Belongs to the WXG100 family
I4W80_18235	COG2195	Cleaves the N-terminal amino acid of tripeptides
I4W80_18250	COG1737	Transcriptional regulator
I4W80_18255	COG2084	Dehydrogenase
I4W80_18265	COG2610	gluconate transmembrane transporter activity
I4W80_18270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I4W80_18295	COG2723	6-phospho-beta-galactosidase activity
I4W80_18300	COG2190	(PTS) system
I4W80_18300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_18300	COG1263	PTS System
I4W80_18305	COG3711	transcriptional antiterminator
I4W80_18310	COG3878	Protein conserved in bacteria
I4W80_18320	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I4W80_18325	COG1122	ATPase activity
I4W80_18330	COG4721	ABC-type cobalt transport system, permease component
I4W80_18335	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I4W80_18370	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I4W80_18375	COG0778	Nitroreductase
I4W80_18380	COG1846	Transcriptional regulator
I4W80_18385	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I4W80_18390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I4W80_18395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I4W80_18400	COG2390	Transcriptional regulator
I4W80_18410	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I4W80_18410	COG2755	lipolytic protein G-D-S-L family
I4W80_18415	COG0477	Major facilitator Superfamily
I4W80_18420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I4W80_18425	COG2226	methyltransferase
I4W80_18435	COG0561	phosphatase activity
I4W80_18440	COG0789	Transcriptional regulator
I4W80_18445	COG0673	inositol 2-dehydrogenase activity
I4W80_18450	COG0840	transmembrane signaling receptor activity
I4W80_18455	COG1113	amino acid transport
I4W80_18460	COG4335	DNA alkylation repair
I4W80_18470	COG1070	Carbohydrate kinase
I4W80_18475	COG1737	Transcriptional regulator
I4W80_18505	COG0583	DNA-binding transcription factor activity
I4W80_18510	COG1609	Transcriptional regulator
I4W80_18515	COG2182	Extracellular solute-binding protein
I4W80_18520	COG1175	transmembrane transport
I4W80_18525	COG3833	ABC-type maltose transport systems, permease component
I4W80_18535	COG1874	Beta-galactosidase
I4W80_18540	COG2851	Citrate transporter
I4W80_18550	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I4W80_18555	COG1131	(ABC) transporter
I4W80_18560	COG2824	Alkylphosphonate utilization operon protein PhnA
I4W80_18565	COG1929	Belongs to the glycerate kinase type-1 family
I4W80_18570	COG2610	gluconate transmembrane transporter activity
I4W80_18575	COG3835	regulator
I4W80_18580	COG1309	transcriptional regulator
I4W80_18585	COG2814	Major facilitator Superfamily
I4W80_18595	COG1136	(ABC) transporter
I4W80_18600	COG0457	Tetratricopeptide repeat
I4W80_18605	COG3711	transcriptional antiterminator
I4W80_18610	COG2723	6-phospho-beta-galactosidase activity
I4W80_18615	COG1263	PTS System
I4W80_18615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_18615	COG2190	(PTS) system
I4W80_18640	COG0494	nUDIX hydrolase
I4W80_18655	COG1113	amino acid transport
I4W80_18660	COG1609	Transcriptional regulator
I4W80_18665	COG2814	Major facilitator Superfamily
I4W80_18670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I4W80_18675	COG2814	Major facilitator Superfamily
I4W80_18695	COG5444	nuclease activity
I4W80_18705	COG2723	6-phospho-beta-galactosidase activity
I4W80_18710	COG1263	PTS System
I4W80_18710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4W80_18710	COG2190	(PTS) system
I4W80_18715	COG2188	Transcriptional regulator
I4W80_18725	COG0384	phenazine biosynthesis protein PhzF
I4W80_18730	COG0583	DNA-binding transcription factor activity
I4W80_18750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I4W80_18765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I4W80_18790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I4W80_18795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I4W80_18805	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I4W80_18815	COG4720	Psort location CytoplasmicMembrane, score
I4W80_18835	COG0456	acetyltransferase
I4W80_18840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I4W80_18845	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I4W80_18850	COG4853	Protein conserved in bacteria
I4W80_18855	COG4863	YycH protein
I4W80_18860	COG5002	protein histidine kinase activity
I4W80_18865	COG0745	RESPONSE REGULATOR receiver
I4W80_18890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I4W80_18900	COG2311	Membrane
I4W80_18905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I4W80_18910	COG1309	transcriptional regulator
I4W80_18915	COG2124	cytochrome p450
I4W80_18920	COG0346	lactoylglutathione lyase activity
I4W80_18925	COG0305	Participates in initiation and elongation during chromosome replication
I4W80_18940	COG2819	hydrolase of the alpha beta superfamily
I4W80_18945	COG2207	Transcriptional regulator
I4W80_18945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I4W80_18950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I4W80_18955	COG2819	hydrolase of the alpha beta superfamily
I4W80_18960	COG3093	addiction module antidote protein HigA
I4W80_18965	COG2807	transmembrane transport
I4W80_18970	COG0359	binds to the 23S rRNA
I4W80_18975	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I4W80_18980	COG4241	membrane
I4W80_18985	COG1227	inorganic diphosphatase activity
I4W80_18995	COG1595	DNA-templated transcription, initiation
I4W80_19005	COG0753	catalase activity
I4W80_19010	COG0655	NAD(P)H dehydrogenase (quinone) activity
I4W80_19015	COG0400	carboxylic ester hydrolase activity
I4W80_19020	COG0346	lactoylglutathione lyase activity
I4W80_19025	COG1174	glycine betaine transport
I4W80_19030	COG0517	IMP dehydrogenase activity
I4W80_19030	COG1125	glycine betaine transport
I4W80_19035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I4W80_19040	COG0629	single-stranded DNA binding
I4W80_19045	COG0360	Binds together with S18 to 16S ribosomal RNA
I4W80_19050	COG0012	GTP binding
I4W80_19055	COG4481	Protein conserved in bacteria
I4W80_19070	COG3949	Membrane
I4W80_19080	COG1475	DNA binding
I4W80_19085	COG1192	Involved in chromosome partitioning
I4W80_19095	COG1475	DNA binding
I4W80_19100	COG0357	Ribosomal RNA small subunit methyltransferase G
I4W80_19105	COG0445	tRNA wobble uridine modification
I4W80_19110	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I4W80_19115	COG1847	R3H domain protein
I4W80_19120	COG0706	membrane insertase activity
I4W80_19125	COG0594	ribonuclease P activity
I4W80_19130	COG0230	Belongs to the bacterial ribosomal protein bL34 family