locus-tag	class	description
NP445_00010	COG0516	GMP reductase activity
NP445_00010	COG0517	IMP dehydrogenase activity
NP445_00025	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NP445_00030	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NP445_00035	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NP445_00050	COG1428	Deoxynucleoside kinase
NP445_00060	COG1388	LysM domain
NP445_00060	COG3858	chitin binding
NP445_00065	COG1335	isochorismatase
NP445_00070	COG0590	tRNA wobble adenosine to inosine editing
NP445_00080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NP445_00085	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NP445_00090	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NP445_00135	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
NP445_00140	COG3853	Toxic anion resistance protein (TelA)
NP445_00145	COG1982	Orn Lys Arg decarboxylase major
NP445_00150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NP445_00155	COG3870	Protein conserved in bacteria
NP445_00160	COG1728	Protein conserved in bacteria
NP445_00165	COG0470	DNA polymerase III
NP445_00170	COG1774	PSP1 C-terminal conserved region
NP445_00175	COG4467	Involved in initiation control of chromosome replication
NP445_00180	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NP445_00185	COG2827	Endonuclease containing a URI domain
NP445_00190	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NP445_00195	COG2002	toxin-antitoxin pair type II binding
NP445_00200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP445_00200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP445_00205	COG0084	hydrolase, TatD family'
NP445_00210	COG3583	domain protein
NP445_00210	COG3584	3D domain protein
NP445_00215	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NP445_00220	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NP445_00230	COG4466	Protein conserved in bacteria
NP445_00240	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NP445_00245	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP445_00250	COG0251	oxidation-reduction process
NP445_00255	COG2088	sporulation resulting in formation of a cellular spore
NP445_00265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NP445_00270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NP445_00275	COG0193	aminoacyl-tRNA hydrolase activity
NP445_00285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NP445_00290	COG2002	toxin-antitoxin pair type II binding
NP445_00295	COG2244	polysaccharide biosynthetic process
NP445_00300	COG3956	TIGRFAM MazG family protein
NP445_00305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NP445_00320	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NP445_00325	COG1098	S1 RNA binding domain
NP445_00340	COG2208	phosphoserine phosphatase activity
NP445_00345	COG2304	oxidoreductase activity
NP445_00350	COG0515	serine threonine protein kinase
NP445_00355	COG0037	tRNA processing
NP445_00360	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NP445_00365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NP445_00370	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NP445_00375	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NP445_00380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP445_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP445_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NP445_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
NP445_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP445_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NP445_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NP445_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NP445_00420	COG1396	sequence-specific DNA binding
NP445_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP445_00430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NP445_00510	COG4463	regulation of RNA biosynthetic process
NP445_00515	COG3880	PFAM UvrB UvrC protein
NP445_00520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
NP445_00525	COG0542	response to heat
NP445_00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NP445_00535	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NP445_00540	COG4956	integral membrane protein (PIN domain superfamily)
NP445_00545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NP445_00550	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NP445_00555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NP445_00560	COG1045	serine acetyltransferase
NP445_00570	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NP445_00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP445_00580	COG3688	RNA-binding protein containing a PIN domain
NP445_00585	COG1595	DNA-templated transcription, initiation
NP445_00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NP445_00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP445_00600	COG0250	Participates in transcription elongation, termination and antitermination
NP445_00610	COG0081	regulation of translation
NP445_00615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NP445_00620	COG0222	ribosome binding
NP445_00625	COG2813	Specifically methylates the guanine in position
NP445_00640	COG1358	cellular component organization or biogenesis
NP445_00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NP445_00650	COG0049	tRNA binding
NP445_00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NP445_00660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NP445_00665	COG0596	Alpha beta hydrolase
NP445_00675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NP445_00680	COG0088	Forms part of the polypeptide exit tunnel
NP445_00685	COG0089	rRNA binding
NP445_00690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NP445_00695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NP445_00700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NP445_00705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NP445_00710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NP445_00715	COG0255	Belongs to the universal ribosomal protein uL29 family
NP445_00720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NP445_00725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NP445_00730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NP445_00735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NP445_00740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NP445_00745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NP445_00750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NP445_00755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NP445_00760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NP445_00765	COG1841	ribosomal large subunit assembly
NP445_00770	COG0200	Binds to the 23S rRNA
NP445_00775	COG0201	protein transport
NP445_00780	COG0563	adenylate kinase activity
NP445_00785	COG0024	Methionine aminopeptidase
NP445_00790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NP445_00795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NP445_00800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NP445_00805	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NP445_00810	COG0202	RNA polymerase activity
NP445_00815	COG0203	ribosomal protein L17
NP445_00820	COG1122	ATPase activity
NP445_00825	COG1122	ATPase activity
NP445_00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NP445_00835	COG0101	tRNA pseudouridine synthase activity
NP445_00840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NP445_00845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NP445_00865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP445_00890	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP445_00895	COG0489	protein tyrosine kinase activity
NP445_00905	COG2194	sulfuric ester hydrolase activity
NP445_00910	COG0726	polysaccharide deacetylase
NP445_00940	COG0659	secondary active sulfate transmembrane transporter activity
NP445_00945	COG0385	Bile acid
NP445_00950	COG3876	Protein conserved in bacteria
NP445_00955	COG1472	Belongs to the glycosyl hydrolase 3 family
NP445_00960	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NP445_00965	COG1263	PTS System
NP445_00965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP445_00970	COG1737	Transcriptional regulator
NP445_01010	COG1595	DNA-templated transcription, initiation
NP445_01015	COG5662	AntiSigma factor
NP445_01020	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NP445_01025	COG4856	YbbR-like protein
NP445_01030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP445_01035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NP445_01045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NP445_01060	COG1131	(ABC) transporter
NP445_01070	COG0577	efflux transmembrane transporter activity
NP445_01070	COG1136	(ABC) transporter
NP445_01080	COG1695	Transcriptional regulator
NP445_01095	COG0535	radical SAM domain protein
NP445_01100	COG1266	CAAX protease self-immunity
NP445_01105	COG1131	(ABC) transporter
NP445_01115	COG1413	lyase activity
NP445_01120	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP445_01135	COG2311	Membrane
NP445_01155	COG1476	TRANSCRIPTIONal
NP445_01165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NP445_01170	COG2207	Transcriptional regulator
NP445_01175	COG1309	transcriptional regulator
NP445_01190	COG1113	amino acid transport
NP445_01195	COG0584	glycerophosphoryl diester phosphodiesterase
NP445_01200	COG2271	Major facilitator Superfamily
NP445_01210	COG1331	Highly conserved protein containing a thioredoxin domain
NP445_01220	COG0457	Tetratricopeptide repeat
NP445_01225	COG2856	Zn peptidase
NP445_01230	COG1396	sequence-specific DNA binding
NP445_01255	COG1674	ftsk spoiiie
NP445_01260	COG2946	Replication initiation factor
NP445_01370	COG0433	COG0433 Predicted ATPase
NP445_01375	COG5644	endopeptidase inhibitor activity
NP445_01380	COG0791	NLP P60 protein
NP445_01380	COG0741	lytic transglycosylase activity
NP445_01405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NP445_01420	COG0640	Transcriptional regulator
NP445_01435	COG1937	Protein conserved in bacteria
NP445_01440	COG2210	Belongs to the sulfur carrier protein TusA family
NP445_01450	COG0425	Belongs to the sulfur carrier protein TusA family
NP445_01450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP445_01455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP445_01455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP445_01460	COG0425	Belongs to the sulfur carrier protein TusA family
NP445_01465	COG0730	response to heat
NP445_01475	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NP445_01480	COG2814	Major facilitator Superfamily
NP445_01495	COG1846	Transcriptional regulator
NP445_01500	COG1683	Conserved Protein
NP445_01510	COG0656	L-ascorbic acid biosynthetic process
NP445_01515	COG0371	Dehydrogenase
NP445_01520	COG1054	Belongs to the UPF0176 family
NP445_01525	COG0531	amino acid
NP445_01535	COG3711	transcriptional antiterminator
NP445_01540	COG1263	PTS System
NP445_01540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP445_01540	COG2190	(PTS) system
NP445_01545	COG2723	6-phospho-beta-galactosidase activity
NP445_01560	COG3711	transcriptional antiterminator
NP445_01560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP445_01565	COG1940	carbohydrate kinase activity
NP445_01570	COG0383	alpha-mannosidase activity
NP445_01575	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP445_01580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP445_01585	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP445_01585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP445_01590	COG1404	Belongs to the peptidase S8 family
NP445_01605	COG0833	amino acid
NP445_01610	COG2040	homocysteine
NP445_01615	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP445_01620	COG1695	Transcriptional regulator
NP445_01635	COG2814	Major facilitator Superfamily
NP445_01640	COG0456	acetyltransferase
NP445_01655	COG1404	Belongs to the peptidase S8 family
NP445_01665	COG1309	transcriptional regulator
NP445_01670	COG1917	Cupin 2, conserved barrel domain protein
NP445_01675	COG1063	alcohol dehydrogenase
NP445_01680	COG1846	Transcriptional regulator
NP445_01685	COG0318	PFAM AMP-dependent synthetase and ligase
NP445_01690	COG0531	amino acid
NP445_01700	COG0596	Alpha beta hydrolase
NP445_01705	COG1115	amino acid carrier protein
NP445_01710	COG2066	Belongs to the glutaminase family
NP445_01715	COG4191	Histidine kinase
NP445_01720	COG0784	Response regulator, receiver
NP445_01725	COG1405	negative regulation of cell septum assembly
NP445_01725	COG3012	SEC-C Motif Domain Protein
NP445_01735	COG0667	Aldo Keto reductase
NP445_01740	COG3290	protein histidine kinase activity
NP445_01745	COG3279	Response regulator of the LytR AlgR family
NP445_01750	COG4555	ABC transporter
NP445_01755	COG1668	transmembrane transport
NP445_01775	COG3773	Cell wall hydrolase
NP445_01780	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_01790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP445_01795	COG2310	stress, protein
NP445_01800	COG2310	stress, protein
NP445_01805	COG2310	stress, protein
NP445_01810	COG0861	Integral membrane protein TerC family
NP445_01840	COG3853	Toxic anion resistance protein (TelA)
NP445_01845	COG0517	IMP dehydrogenase activity
NP445_01845	COG4175	Glycine betaine
NP445_01850	COG4176	ABC-type proline glycine betaine transport system permease component
NP445_01855	COG2113	Glycine betaine
NP445_01870	COG1473	amidohydrolase
NP445_01875	COG1288	antiporter activity
NP445_01880	COG0039	L-malate dehydrogenase activity
NP445_01885	COG1620	l-lactate permease
NP445_01890	COG1609	Transcriptional regulator
NP445_01895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP445_01900	COG0561	phosphatase activity
NP445_01905	COG0673	inositol 2-dehydrogenase activity
NP445_01910	COG0738	Major facilitator superfamily
NP445_01915	COG1280	lysine exporter protein (LysE YggA)
NP445_01930	COG3403	YqcI/YcgG family
NP445_01935	COG1113	amino acid transport
NP445_01940	COG3665	Urea carboxylase-associated protein
NP445_01945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NP445_01955	COG1012	belongs to the aldehyde dehydrogenase family
NP445_01960	COG0710	3-dehydroquinate dehydratase activity
NP445_01965	COG0028	Belongs to the TPP enzyme family
NP445_01975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NP445_01980	COG2271	Major facilitator Superfamily
NP445_01995	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NP445_02000	COG2226	methyltransferase
NP445_02005	COG0583	DNA-binding transcription factor activity
NP445_02010	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP445_02015	COG3458	cephalosporin-C deacetylase activity
NP445_02025	COG3541	Predicted nucleotidyltransferase
NP445_02030	COG0506	proline dehydrogenase activity
NP445_02035	COG1012	belongs to the aldehyde dehydrogenase family
NP445_02040	COG2508	Transcriptional regulator
NP445_02045	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NP445_02050	COG0765	amino acid transport
NP445_02055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP445_02065	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NP445_02070	COG1522	sequence-specific DNA binding
NP445_02075	COG2746	aminoglycoside 3-N-acetyltransferase activity
NP445_02085	COG0840	transmembrane signaling receptor activity
NP445_02085	COG3290	protein histidine kinase activity
NP445_02090	COG3209	COG3209 Rhs family protein
NP445_02110	COG3842	ATPase activity
NP445_02115	COG1176	ABC-type spermidine putrescine transport system, permease component I
NP445_02125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP445_02130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP445_02135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP445_02150	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NP445_02155	COG0697	spore germination
NP445_02160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP445_02170	COG3708	Transcriptional regulator
NP445_02170	COG2207	Transcriptional regulator
NP445_02180	COG2364	Membrane
NP445_02185	COG0737	Belongs to the 5'-nucleotidase family
NP445_02190	COG3764	Sortase (surface protein transpeptidase)
NP445_02195	COG2002	toxin-antitoxin pair type II binding
NP445_02200	COG1126	abc transporter atp-binding protein
NP445_02205	COG0765	amino acid transport
NP445_02210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP445_02215	COG0833	amino acid
NP445_02220	COG3104	oligopeptide transport
NP445_02225	COG5434	Belongs to the glycosyl hydrolase 28 family
NP445_02230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP445_02235	COG0456	acetyltransferase
NP445_02240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP445_02245	COG0765	amino acid transport
NP445_02250	COG1126	abc transporter atp-binding protein
NP445_02255	COG1473	amidohydrolase
NP445_02260	COG2079	MmgE PrpD family protein
NP445_02270	COG0745	RESPONSE REGULATOR receiver
NP445_02275	COG5002	protein histidine kinase activity
NP445_02275	COG3850	Histidine kinase
NP445_02280	COG1366	Belongs to the anti-sigma-factor antagonist family
NP445_02285	COG0527	aspartate kinase activity
NP445_02290	COG2814	Major facilitator Superfamily
NP445_02295	COG1309	transcriptional regulator
NP445_02305	COG0640	Transcriptional regulator
NP445_02315	COG0583	DNA-binding transcription factor activity
NP445_02320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP445_02325	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NP445_02330	COG0531	amino acid
NP445_02335	COG1012	belongs to the aldehyde dehydrogenase family
NP445_02340	COG2249	NAD(P)H dehydrogenase (quinone) activity
NP445_02345	COG4549	nuclear export factor GLE1
NP445_02350	COG2372	response to copper ion
NP445_02350	COG1276	copper resistance
NP445_02355	COG2213	PTS system mannitol-specific
NP445_02360	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP445_02365	COG0246	Mannitol dehydrogenase
NP445_02370	COG0840	transmembrane signaling receptor activity
NP445_02405	COG0346	lactoylglutathione lyase activity
NP445_02415	COG0561	phosphatase activity
NP445_02430	COG0457	Tetratricopeptide repeat
NP445_02440	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NP445_02445	COG1914	H( )-stimulated, divalent metal cation uptake system
NP445_02450	COG4336	lyase activity
NP445_02455	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NP445_02460	COG1984	allophanate hydrolase subunit 2
NP445_02465	COG1414	Transcriptional regulator
NP445_02470	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NP445_02475	COG2755	lipolytic protein G-D-S-L family
NP445_02485	COG3711	transcriptional antiterminator
NP445_02490	COG2226	methyltransferase
NP445_02495	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_02500	COG3871	stress protein (general stress protein 26)
NP445_02520	COG2814	Major facilitator Superfamily
NP445_02525	COG1802	Transcriptional regulator
NP445_02530	COG2207	Transcriptional regulator
NP445_02530	COG1917	Cupin 2, conserved barrel domain protein
NP445_02535	COG0697	spore germination
NP445_02540	COG0473	3-isopropylmalate dehydrogenase activity
NP445_02545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP445_02545	COG0551	DNA topoisomerase type I activity
NP445_02550	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
NP445_02555	COG3706	GGDEF domain
NP445_02560	COG5298	Protein conserved in bacteria
NP445_02565	COG1215	transferase activity, transferring glycosyl groups
NP445_02575	COG0531	amino acid
NP445_02580	COG0028	Belongs to the TPP enzyme family
NP445_02585	COG5444	nuclease activity
NP445_02630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP445_02635	COG1914	H( )-stimulated, divalent metal cation uptake system
NP445_02640	COG2261	transglycosylase associated protein
NP445_02645	COG2217	Heavy metal translocating P-type atpase
NP445_02650	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP445_02655	COG3290	protein histidine kinase activity
NP445_02660	COG4565	transcriptional regulatory protein
NP445_02665	COG1301	dicarboxylic acid transport
NP445_02670	COG0628	permease
NP445_02675	COG1301	dicarboxylic acid transport
NP445_02680	COG1131	(ABC) transporter
NP445_02685	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NP445_02700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP445_02705	COG1181	Belongs to the D-alanine--D-alanine ligase family
NP445_02710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NP445_02725	COG0513	Belongs to the DEAD box helicase family
NP445_02730	COG3402	PFAM membrane-flanked domain
NP445_02735	COG3428	Bacterial PH domain
NP445_02740	COG0705	Rhomboid family
NP445_02745	COG0736	holo-[acyl-carrier-protein] synthase activity
NP445_02750	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NP445_02755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP445_02760	COG0864	Transcriptional regulator
NP445_02765	COG2337	Toxic component of a toxin-antitoxin (TA) module
NP445_02770	COG1366	Belongs to the anti-sigma-factor antagonist family
NP445_02775	COG1366	Belongs to the anti-sigma-factor antagonist family
NP445_02780	COG2172	sigma factor antagonist activity
NP445_02785	COG2208	phosphoserine phosphatase activity
NP445_02790	COG1366	Belongs to the anti-sigma-factor antagonist family
NP445_02795	COG2172	sigma factor antagonist activity
NP445_02800	COG1191	sigma factor activity
NP445_02805	COG2208	phosphoserine phosphatase activity
NP445_02810	COG2183	response to ionizing radiation
NP445_02820	COG3091	SprT-like family
NP445_02825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP445_02830	COG0022	dehydrogenase e1 component
NP445_02835	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP445_02840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP445_02845	COG3284	Transcriptional regulator
NP445_02895	COG1278	Cold shock
NP445_02900	COG1329	Transcriptional regulator
NP445_02905	COG1064	alcohol dehydrogenase
NP445_02910	COG0789	Transcriptional regulator
NP445_02925	COG0477	Major facilitator Superfamily
NP445_02930	COG0657	acetylesterase activity
NP445_02940	COG4221	oxidoreductase activity
NP445_02950	COG0252	asparaginase activity
NP445_02955	COG2267	carboxylic ester hydrolase activity
NP445_02975	COG2814	Major facilitator Superfamily
NP445_03020	COG1309	transcriptional regulator
NP445_03025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP445_03030	COG1846	Transcriptional regulator
NP445_03035	COG0778	Nitroreductase
NP445_03050	COG1396	sequence-specific DNA binding
NP445_03060	COG0456	acetyltransferase
NP445_03070	COG4122	O-methyltransferase activity
NP445_03080	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NP445_03085	COG0697	spore germination
NP445_03095	COG1301	dicarboxylic acid transport
NP445_03135	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NP445_03140	COG0802	atpase or kinase
NP445_03145	COG1214	PFAM Peptidase M22, glycoprotease
NP445_03150	COG0456	acetyltransferase
NP445_03155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NP445_03160	COG0488	(ABC) transporter
NP445_03165	COG0315	cyclic pyranopterin monophosphate synthase activity
NP445_03170	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NP445_03175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP445_03195	COG1266	CAAX protease self-immunity
NP445_03200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NP445_03205	COG0459	protein refolding
NP445_03210	COG4974	Belongs to the 'phage' integrase family
NP445_03265	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NP445_03270	COG0823	Involved in the tonB-independent uptake of proteins
NP445_03280	COG2132	Multicopper oxidase
NP445_03285	COG1113	amino acid transport
NP445_03290	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NP445_03295	COG0714	Associated with various cellular activities
NP445_03300	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
NP445_03305	COG1305	Transglutaminase-like
NP445_03310	COG0519	Catalyzes the synthesis of GMP from XMP
NP445_03310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NP445_03315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NP445_03325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP445_03375	COG1595	DNA-templated transcription, initiation
NP445_03385	COG2814	Major facilitator Superfamily
NP445_03390	COG0583	DNA-binding transcription factor activity
NP445_03395	COG2252	PERMEase
NP445_03405	COG5583	Uncharacterized small protein (DUF2292)
NP445_03410	COG3064	Membrane
NP445_03415	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
NP445_03425	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NP445_03430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NP445_03435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NP445_03440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NP445_03445	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NP445_03450	COG0047	phosphoribosylformylglycinamidine synthase activity
NP445_03455	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NP445_03460	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NP445_03465	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NP445_03470	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NP445_03475	COG0138	bifunctional purine biosynthesis protein purh
NP445_03480	COG0151	Belongs to the GarS family
NP445_03500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP445_03505	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NP445_03510	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NP445_03515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP445_03525	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NP445_03530	COG4496	protein, YerC YecD
NP445_03540	COG0069	glutamate synthase activity
NP445_03555	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
NP445_03560	COG0210	DNA helicase
NP445_03565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NP445_03570	COG4851	CamS sex pheromone cAM373 precursor
NP445_03575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP445_03580	COG1285	pathogenesis
NP445_03585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP445_03590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NP445_03595	COG0154	amidase activity
NP445_03600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NP445_03605	COG1309	transcriptional regulator
NP445_03610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NP445_03615	COG1957	nucleoside hydrolase
NP445_03620	COG1597	lipid kinase activity
NP445_03625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NP445_03635	COG0514	ATP-dependent DNA helicase (RecQ)
NP445_03640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP445_03655	COG1959	2 iron, 2 sulfur cluster binding
NP445_03660	COG0492	ferredoxin-NADP+ reductase activity
NP445_03675	COG1486	melibiose metabolic process
NP445_03685	COG2211	Major facilitator Superfamily
NP445_03715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NP445_03720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP445_03725	COG1442	glycosyl transferase family 8
NP445_03730	COG1216	Glycosyl transferase, family 2
NP445_03735	COG1442	glycosyl transferase family 8
NP445_03740	COG2223	nitrite transmembrane transporter activity
NP445_03750	COG0471	metal ion transport
NP445_03765	COG0071	Belongs to the small heat shock protein (HSP20) family
NP445_03780	COG0531	amino acid
NP445_03785	COG0463	Glycosyl transferase, family 2
NP445_03785	COG0457	Tetratricopeptide repeat
NP445_03790	COG0488	(ABC) transporter
NP445_03795	COG1469	GTP cyclohydrolase I activity
NP445_03800	COG0789	Transcriptional regulator
NP445_03805	COG2814	Major facilitator Superfamily
NP445_03810	COG0488	(ABC) transporter
NP445_03815	COG0513	Belongs to the DEAD box helicase family
NP445_03820	COG2130	NADP-dependent
NP445_03840	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP445_03840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP445_03845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NP445_03855	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP445_03855	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP445_03865	COG3290	protein histidine kinase activity
NP445_03870	COG4565	transcriptional regulatory protein
NP445_03875	COG3181	Tripartite tricarboxylate transporter family receptor
NP445_03880	COG2851	Citrate transporter
NP445_03890	COG3479	Phenolic acid decarboxylase
NP445_03895	COG1695	Transcriptional regulator
NP445_03900	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
NP445_03910	COG1254	Belongs to the acylphosphatase family
NP445_03915	COG2258	MOSC domain
NP445_03930	COG0024	Methionine aminopeptidase
NP445_03935	COG1263	PTS System
NP445_03935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP445_03940	COG3739	integral membrane protein
NP445_03955	COG1368	sulfuric ester hydrolase activity
NP445_03960	COG0076	glutamate decarboxylase activity
NP445_03965	COG0840	transmembrane signaling receptor activity
NP445_03975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP445_03975	COG1263	PTS System
NP445_03980	COG0366	Alpha amylase catalytic
NP445_03985	COG2188	Transcriptional regulator
NP445_03995	COG0737	Belongs to the 5'-nucleotidase family
NP445_04000	COG0693	protein deglycase activity
NP445_04005	COG4840	Belongs to the UPF0435 family
NP445_04010	COG1115	amino acid carrier protein
NP445_04015	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP445_04020	COG4980	gas vesicle protein
NP445_04025	COG1295	ribonuclease BN
NP445_04030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP445_04035	COG0477	Major facilitator Superfamily
NP445_04045	COG0387	Pfam Sodium calcium exchanger
NP445_04055	COG0217	transcriptional regulatory protein
NP445_04065	COG0668	transmembrane transport
NP445_04070	COG0535	radical SAM domain protein
NP445_04080	COG0726	polysaccharide deacetylase
NP445_04090	COG0598	Magnesium transport protein CorA
NP445_04100	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NP445_04105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NP445_04120	COG0789	Transcriptional regulator
NP445_04125	COG2814	Major facilitator Superfamily
NP445_04175	COG2076	Multidrug Resistance protein
NP445_04180	COG2076	Multidrug Resistance protein
NP445_04185	COG1309	transcriptional regulator
NP445_04195	COG4637	Psort location Cytoplasmic, score
NP445_04200	COG2755	lipolytic protein G-D-S-L family
NP445_04205	COG0492	ferredoxin-NADP+ reductase activity
NP445_04210	COG2169	Transcriptional regulator
NP445_04215	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NP445_04220	COG1132	(ABC) transporter
NP445_04225	COG1742	UPF0060 membrane protein
NP445_04230	COG1595	DNA-templated transcription, initiation
NP445_04250	COG2318	DinB family
NP445_04260	COG1846	Transcriptional regulator
NP445_04265	COG0392	lysyltransferase activity
NP445_04265	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NP445_04285	COG0778	Nitroreductase
NP445_04300	COG1090	epimerase
NP445_04305	COG2137	regulation of response to DNA damage stimulus
NP445_04330	COG0463	Glycosyl transferase, family 2
NP445_04335	COG4485	Bacterial membrane protein, YfhO
NP445_04350	COG2140	Oxalate decarboxylase
NP445_04360	COG1191	sigma factor activity
NP445_04370	COG1988	membrane-bound metal-dependent
NP445_04375	COG1194	a g-specific adenine glycosylase
NP445_04385	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_04400	COG3557	Belongs to the UPF0374 family
NP445_04405	COG1132	(ABC) transporter
NP445_04410	COG0444	Belongs to the ABC transporter superfamily
NP445_04415	COG4608	Belongs to the ABC transporter superfamily
NP445_04420	COG0747	negative chemotaxis
NP445_04425	COG0601	transmembrane transport
NP445_04430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP445_04435	COG4129	membrane
NP445_04440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NP445_04445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NP445_04450	COG0735	belongs to the Fur family
NP445_04600	COG1368	sulfuric ester hydrolase activity
NP445_04605	COG0681	Belongs to the peptidase S26 family
NP445_04610	COG2873	o-acetylhomoserine
NP445_04620	COG1116	anion transmembrane transporter activity
NP445_04630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP445_04645	COG1131	(ABC) transporter
NP445_04675	COG3382	B3 4 domain protein
NP445_04680	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NP445_04690	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NP445_04695	COG2766	serine protein kinase
NP445_04700	COG2718	Belongs to the UPF0229 family
NP445_04705	COG1566	PFAM secretion protein HlyD family protein
NP445_04710	COG2814	Major facilitator Superfamily
NP445_04715	COG0655	NAD(P)H dehydrogenase (quinone) activity
NP445_04725	COG1278	Cold shock
NP445_04730	COG3706	GGDEF domain
NP445_04755	COG5577	PFAM Coat F domain
NP445_04760	COG5002	protein histidine kinase activity
NP445_04765	COG4085	toxin activity
NP445_04765	COG0737	Belongs to the 5'-nucleotidase family
NP445_04765	COG1525	nuclease
NP445_04770	COG3764	Sortase (surface protein transpeptidase)
NP445_04775	COG0564	pseudouridine synthase activity
NP445_04785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP445_04790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP445_04790	COG3153	acetyltransferase
NP445_04810	COG3835	regulator
NP445_04815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP445_04820	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NP445_04825	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NP445_04830	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NP445_04835	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NP445_04840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP445_04845	COG4585	Histidine kinase
NP445_04845	COG2203	Gaf domain
NP445_04850	COG2197	response regulator
NP445_04865	COG0753	catalase activity
NP445_04870	COG1959	2 iron, 2 sulfur cluster binding
NP445_04875	COG1017	nitric oxide dioxygenase activity
NP445_04875	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP445_04880	COG2719	SpoVR family
NP445_04885	COG1785	Belongs to the alkaline phosphatase family
NP445_04890	COG0791	NLP P60 protein
NP445_04890	COG1388	LysM domain
NP445_04895	COG0531	amino acid
NP445_04910	COG1595	DNA-templated transcription, initiation
NP445_04915	COG0204	Acyl-transferase
NP445_04920	COG1253	flavin adenine dinucleotide binding
NP445_04925	COG0789	Transcriptional regulator
NP445_04930	COG1253	flavin adenine dinucleotide binding
NP445_04945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NP445_04950	COG0584	glycerophosphoryl diester phosphodiesterase
NP445_04960	COG0668	transmembrane transport
NP445_04965	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NP445_04970	COG0726	polysaccharide deacetylase
NP445_04975	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP445_04980	COG0589	response to stress
NP445_04985	COG1132	(ABC) transporter
NP445_04990	COG1132	(ABC) transporter
NP445_04995	COG0702	epimerase
NP445_05005	COG3842	ATPase activity
NP445_05010	COG2508	Transcriptional regulator
NP445_05020	COG0189	ligase activity
NP445_05025	COG0189	ligase activity
NP445_05030	COG4399	Belongs to the UPF0754 family
NP445_05035	COG3679	Belongs to the UPF0342 family
NP445_05040	COG0561	phosphatase activity
NP445_05045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NP445_05055	COG0475	glutathione-regulated potassium exporter activity
NP445_05060	COG0490	domain, Protein
NP445_05070	COG1024	Enoyl-CoA hydratase
NP445_05080	COG0420	3'-5' exonuclease activity
NP445_05085	COG4717	serine-type aminopeptidase activity
NP445_05090	COG3481	metal-dependent phosphohydrolase, HD sub domain
NP445_05100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP445_05130	COG1846	Transcriptional regulator
NP445_05135	COG4980	gas vesicle protein
NP445_05150	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NP445_05155	COG0537	adenosine 5'-monophosphoramidase activity
NP445_05160	COG1131	(ABC) transporter
NP445_05165	COG4473	ABC transporter
NP445_05175	COG1473	amidohydrolase
NP445_05185	COG2329	Antibiotic biosynthesis monooxygenase
NP445_05190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP445_05195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NP445_05200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NP445_05205	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NP445_05210	COG1309	transcriptional regulator
NP445_05215	COG1511	domain protein
NP445_05220	COG1363	Peptidase, m42
NP445_05225	COG1301	dicarboxylic acid transport
NP445_05235	COG1234	tRNA 3'-trailer cleavage
NP445_05240	COG0095	Lipoate-protein ligase
NP445_05245	COG0318	PFAM AMP-dependent synthetase and ligase
NP445_05255	COG0501	Belongs to the peptidase M48B family
NP445_05260	COG1404	Belongs to the peptidase S8 family
NP445_05265	COG0406	alpha-ribazole phosphatase activity
NP445_05270	COG0840	transmembrane signaling receptor activity
NP445_05275	COG0723	plastoquinol--plastocyanin reductase activity
NP445_05275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP445_05280	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_05290	COG4903	ComK protein
NP445_05305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP445_05310	COG2814	Major facilitator Superfamily
NP445_05315	COG2732	(Barnase) inhibitor
NP445_05320	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP445_05325	COG4605	iron ion homeostasis
NP445_05330	COG4604	ABC transporter, ATP-binding protein
NP445_05335	COG4607	ABC-type enterochelin transport system periplasmic component
NP445_05340	COG1316	TRANSCRIPTIONal
NP445_05355	COG0398	Pfam SNARE associated Golgi protein
NP445_05360	COG0681	Belongs to the peptidase S26 family
NP445_05365	COG3180	Ammonia monooxygenase
NP445_05380	COG2259	Doxx family
NP445_05385	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NP445_05390	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NP445_05395	COG1074	ATP-dependent DNA helicase activity
NP445_05400	COG0420	3'-5' exonuclease activity
NP445_05405	COG0419	ATPase involved in DNA repair
NP445_05410	COG1403	HNH endonuclease
NP445_05450	COG5337	Spore coat protein CotH
NP445_05455	COG0179	Fumarylacetoacetate (FAA) hydrolase
NP445_05470	COG0367	asparagine synthase
NP445_05485	COG1562	ergosterol biosynthetic process
NP445_05490	COG0534	Mate efflux family protein
NP445_05495	COG2207	Transcriptional regulator
NP445_05495	COG1917	Cupin 2, conserved barrel domain protein
NP445_05520	COG0076	glutamate decarboxylase activity
NP445_05555	COG0646	methionine synthase
NP445_05555	COG1410	methionine synthase
NP445_05560	COG0646	methionine synthase
NP445_05560	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NP445_05565	COG1666	GTP binding
NP445_05570	COG2996	Protein conserved in bacteria
NP445_05575	COG1744	ABC transporter substrate-binding protein PnrA-like
NP445_05580	COG0840	transmembrane signaling receptor activity
NP445_05585	COG1307	EDD domain protein, DegV family
NP445_05590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP445_05610	COG0561	phosphatase activity
NP445_05615	COG1073	alpha beta
NP445_05620	COG2151	metal-sulfur cluster biosynthetic enzyme
NP445_05625	COG0277	FAD linked oxidase domain protein
NP445_05630	COG2271	Major facilitator Superfamily
NP445_05635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NP445_05640	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NP445_05645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NP445_05650	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NP445_05655	COG0505	Belongs to the CarA family
NP445_05660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NP445_05665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NP445_05675	COG2814	Major facilitator Superfamily
NP445_05685	COG2267	carboxylic ester hydrolase activity
NP445_05695	COG1744	ABC transporter substrate-binding protein PnrA-like
NP445_05710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP445_05715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NP445_05720	COG5504	Zn-dependent protease
NP445_05725	COG0444	Belongs to the ABC transporter superfamily
NP445_05730	COG4608	Belongs to the ABC transporter superfamily
NP445_05740	COG0601	transmembrane transport
NP445_05745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP445_05755	COG0180	Tryptophanyl-tRNA synthetase
NP445_05765	COG0601	transmembrane transport
NP445_05770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP445_05775	COG0444	Belongs to the ABC transporter superfamily
NP445_05780	COG4608	Belongs to the ABC transporter superfamily
NP445_05790	COG0456	acetyltransferase
NP445_05795	COG1393	Belongs to the ArsC family
NP445_05800	COG0861	Integral membrane protein TerC family
NP445_05805	COG4862	establishment of competence for transformation
NP445_05810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP445_05820	COG1164	Oligoendopeptidase f
NP445_05830	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NP445_05835	COG2346	COG2346, Truncated hemoglobins
NP445_05840	COG0741	lytic transglycosylase activity
NP445_05845	COG4116	CYTH
NP445_05855	COG2357	RelA SpoT domain protein
NP445_05860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NP445_05865	COG0564	pseudouridine synthase activity
NP445_05870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NP445_05875	COG0569	domain protein
NP445_05875	COG0475	glutathione-regulated potassium exporter activity
NP445_05880	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NP445_05885	COG0352	thiamine-phosphate diphosphorylase activity
NP445_05895	COG2104	thiamine diphosphate biosynthetic process
NP445_05900	COG2022	thiamine diphosphate biosynthetic process
NP445_05905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP445_05910	COG0351	phosphomethylpyrimidine kinase
NP445_05915	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NP445_05975	COG0210	DNA helicase
NP445_05985	COG2153	protein acetylation
NP445_05990	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NP445_05995	COG2382	esterase
NP445_06000	COG0626	cystathionine gamma-synthase activity
NP445_06005	COG0626	cystathionine gamma-synthase activity
NP445_06050	COG0825	malonyl-CoA metabolic process
NP445_06075	COG0457	Tetratricopeptide repeat
NP445_06100	COG0457	Tetratricopeptide repeat
NP445_06120	COG3173	Aminoglycoside phosphotransferase
NP445_06125	COG0583	DNA-binding transcription factor activity
NP445_06145	COG0583	DNA-binding transcription factor activity
NP445_06150	COG2807	transmembrane transport
NP445_06180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP445_06200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP445_06205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP445_06225	COG4195	phage-related replication protein
NP445_06230	COG2856	Zn peptidase
NP445_06235	COG3409	Peptidoglycan-binding domain 1 protein
NP445_06235	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP445_06255	COG0306	phosphate transporter
NP445_06260	COG1392	Phosphate transport regulator
NP445_06270	COG0405	Gamma-glutamyltransferase
NP445_06275	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NP445_06285	COG4208	sulfate ABC transporter
NP445_06290	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NP445_06300	COG3775	system Galactitol-specific IIC component
NP445_06315	COG1063	alcohol dehydrogenase
NP445_06320	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP445_06325	COG0022	dehydrogenase e1 component
NP445_06325	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP445_06330	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP445_06335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP445_06340	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_06345	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_06350	COG2390	Transcriptional regulator
NP445_06360	COG0531	amino acid
NP445_06365	COG0346	lactoylglutathione lyase activity
NP445_06370	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP445_06375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP445_06380	COG2362	D-Aminopeptidase
NP445_06385	COG0601	transmembrane transport
NP445_06390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP445_06395	COG0444	Belongs to the ABC transporter superfamily
NP445_06400	COG4166	transmembrane transport
NP445_06405	COG1619	proteins homologs of microcin C7 resistance protein MccF
NP445_06410	COG4948	Mandelate Racemase Muconate Lactonizing
NP445_06415	COG0791	NLP P60 protein
NP445_06420	COG4608	Belongs to the ABC transporter superfamily
NP445_06425	COG1834	amidinotransferase
NP445_06430	COG1607	acyl-coa hydrolase
NP445_06435	COG1695	Transcriptional regulator
NP445_06450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP445_06460	COG2076	Multidrug Resistance protein
NP445_06465	COG2076	Multidrug Resistance protein
NP445_06475	COG0788	formyltetrahydrofolate deformylase activity
NP445_06480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NP445_06485	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NP445_06490	COG0457	Tetratricopeptide repeat
NP445_06500	COG1764	response to oxidative stress
NP445_06505	COG1846	Transcriptional regulator
NP445_06510	COG1764	response to oxidative stress
NP445_06515	COG0590	tRNA wobble adenosine to inosine editing
NP445_06520	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP445_06525	COG1404	Belongs to the peptidase S8 family
NP445_06540	COG0745	RESPONSE REGULATOR receiver
NP445_06545	COG3850	Histidine kinase
NP445_06545	COG5002	protein histidine kinase activity
NP445_06550	COG3212	peptidase
NP445_06555	COG3212	peptidase
NP445_06565	COG2239	Acts as a magnesium transporter
NP445_06575	COG0583	DNA-binding transcription factor activity
NP445_06585	COG0789	Transcriptional regulator
NP445_06600	COG1846	Transcriptional regulator
NP445_06605	COG5001	Diguanylate cyclase
NP445_06605	COG3300	MHYT domain
NP445_06610	COG0586	Pfam SNARE associated Golgi protein
NP445_06615	COG0861	Integral membrane protein TerC family
NP445_06620	COG1191	sigma factor activity
NP445_06640	COG0501	Belongs to the peptidase M48B family
NP445_06645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP445_06650	COG2323	membrane
NP445_06665	COG3594	Acyltransferase
NP445_06670	COG5002	protein histidine kinase activity
NP445_06675	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NP445_06685	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NP445_06690	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
NP445_06695	COG0436	Aminotransferase
NP445_06700	COG1850	ribulose-bisphosphate carboxylase activity
NP445_06705	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
NP445_06710	COG0235	Class ii aldolase
NP445_06715	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NP445_06725	COG3852	Histidine kinase
NP445_06730	COG1846	Transcriptional regulator
NP445_06735	COG1360	Flagellar Motor Protein
NP445_06740	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NP445_06745	COG0542	response to heat
NP445_06755	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NP445_06760	COG0720	synthase
NP445_06765	COG0602	queuosine metabolic process
NP445_06770	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NP445_06780	COG4873	Protein conserved in bacteria
NP445_06790	COG3773	Cell wall hydrolase
NP445_06795	COG2244	polysaccharide biosynthetic process
NP445_06800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP445_06805	COG2217	Heavy metal translocating P-type atpase
NP445_06810	COG0006	proline dipeptidase activity
NP445_06815	COG1609	Transcriptional regulator
NP445_06820	COG3711	transcriptional antiterminator
NP445_06825	COG1263	PTS System
NP445_06825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP445_06825	COG2190	(PTS) system
NP445_06830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP445_06835	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NP445_06845	COG1533	DNA photolyase activity
NP445_06850	COG0840	transmembrane signaling receptor activity
NP445_06860	COG2084	Dehydrogenase
NP445_06865	COG2340	Cysteine-rich secretory protein family
NP445_06870	COG0768	penicillin binding
NP445_06875	COG4191	Histidine kinase
NP445_06880	COG0436	Aminotransferase
NP445_06885	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NP445_06895	COG1714	RDD family
NP445_06905	COG0835	chemotaxis
NP445_06905	COG0784	Response regulator, receiver
NP445_06925	COG2814	Major facilitator Superfamily
NP445_06930	COG1376	ErfK ybiS ycfS ynhG family protein
NP445_06935	COG1408	metallophosphoesterase
NP445_06940	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_06945	COG2200	EAL domain
NP445_06950	COG3546	catalase activity
NP445_06955	COG4703	Protein of unknown function (DUF1797)
NP445_06960	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NP445_06970	COG0517	IMP dehydrogenase activity
NP445_06975	COG0583	DNA-binding transcription factor activity
NP445_06985	COG0716	FMN binding
NP445_06995	COG0716	FMN binding
NP445_07000	COG2171	N-acyltransferase activity
NP445_07005	COG1473	amidohydrolase
NP445_07015	COG0668	transmembrane transport
NP445_07020	COG0450	alkyl hydroperoxide reductase
NP445_07025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP445_07040	COG0746	molybdenum cofactor guanylyltransferase activity
NP445_07045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP445_07050	COG0303	'Molybdopterin
NP445_07055	COG1763	Mo-molybdopterin cofactor biosynthetic process
NP445_07060	COG0314	molybdopterin synthase activity
NP445_07065	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NP445_07080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP445_07085	COG1136	(ABC) transporter
NP445_07090	COG0577	efflux transmembrane transporter activity
NP445_07095	COG1349	DNA-binding transcription factor activity
NP445_07100	COG1105	Belongs to the carbohydrate kinase PfkB family
NP445_07105	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP445_07105	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP445_07105	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP445_07110	COG0681	Belongs to the peptidase S26 family
NP445_07120	COG0488	(ABC) transporter
NP445_07130	COG2309	aminopeptidase activity
NP445_07140	COG1077	Cell shape determining protein MreB Mrl
NP445_07145	COG2002	toxin-antitoxin pair type II binding
NP445_07150	COG3852	Histidine kinase
NP445_07155	COG2105	PFAM AIG2 family protein
NP445_07155	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
NP445_07160	COG0569	domain protein
NP445_07165	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NP445_07170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NP445_07175	COG5503	Protein of unknown function (DUF1447)
NP445_07180	COG0561	phosphatase activity
NP445_07185	COG0242	peptide deformylase activity
NP445_07200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP445_07205	COG0022	dehydrogenase e1 component
NP445_07210	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP445_07215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP445_07220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP445_07230	COG1982	Orn Lys Arg decarboxylase major
NP445_07235	COG4476	Belongs to the UPF0223 family
NP445_07240	COG4493	Belongs to the UPF0637 family
NP445_07250	COG0483	inositol monophosphate 1-phosphatase activity
NP445_07275	COG1217	gtp-binding protein TYPA
NP445_07285	COG4896	Protein conserved in bacteria
NP445_07295	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NP445_07300	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NP445_07305	COG2066	Belongs to the glutaminase family
NP445_07310	COG4838	Belongs to the UPF0358 family
NP445_07315	COG0772	Belongs to the SEDS family
NP445_07320	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NP445_07325	COG0415	Belongs to the DNA photolyase family
NP445_07330	COG1612	heme a metabolic process
NP445_07335	COG0109	protoheme IX farnesyltransferase activity
NP445_07340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NP445_07340	COG2010	Cytochrome c
NP445_07345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NP445_07350	COG1845	cytochrome c oxidase, subunit III
NP445_07355	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NP445_07360	COG3336	cytochrome c oxidase
NP445_07370	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NP445_07375	COG2340	Cysteine-rich secretory protein family
NP445_07395	COG3679	Belongs to the UPF0342 family
NP445_07400	COG4471	UPF0298 protein
NP445_07405	COG0742	ribosomal rna small subunit methyltransferase
NP445_07410	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NP445_07415	COG3314	Sporulation integral membrane protein YlbJ
NP445_07420	COG1752	Esterase of the alpha-beta hydrolase superfamily
NP445_07425	COG3480	Lon protease (S16) C-terminal proteolytic domain
NP445_07435	COG1399	metal-binding, possibly nucleic acid-binding protein
NP445_07440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NP445_07450	COG0454	-acetyltransferase
NP445_07455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NP445_07460	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
NP445_07465	COG2001	Belongs to the MraZ family
NP445_07470	COG0275	rRNA processing
NP445_07475	COG4839	cell division protein FtsL
NP445_07480	COG0768	penicillin binding
NP445_07485	COG0768	penicillin binding
NP445_07490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NP445_07495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP445_07500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NP445_07505	COG0772	Belongs to the SEDS family
NP445_07510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP445_07515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NP445_07520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NP445_07525	COG3879	Bacterial protein of unknown function (DUF881)
NP445_07530	COG3879	Bacterial protein of unknown function (DUF881)
NP445_07535	COG3856	small basic protein
NP445_07540	COG0849	cell division
NP445_07545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NP445_07550	COG1404	Belongs to the peptidase S8 family
NP445_07550	COG4412	M6 family metalloprotease domain protein
NP445_07560	COG1191	sigma factor activity
NP445_07565	COG1191	sigma factor activity
NP445_07570	COG2390	Transcriptional regulator
NP445_07585	COG3730	PTS system glucitol sorbitol-specific
NP445_07590	COG3732	PTS system glucitol sorbitol-specific
NP445_07600	COG1119	ATPase activity
NP445_07605	COG1873	PFAM PRC-barrel domain
NP445_07610	COG1496	oxidoreductase activity
NP445_07615	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NP445_07620	COG1799	cell septum assembly
NP445_07625	COG0762	integral membrane protein
NP445_07630	COG2302	S4 RNA-binding domain
NP445_07635	COG3599	regulation of cell shape
NP445_07640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NP445_07645	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP445_07650	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NP445_07655	COG0564	pseudouridine synthase activity
NP445_07660	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NP445_07665	COG2233	PERMEase
NP445_07670	COG0540	Belongs to the ATCase OTCase family
NP445_07675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NP445_07680	COG0505	Belongs to the CarA family
NP445_07685	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NP445_07690	COG0543	2 iron, 2 sulfur cluster binding
NP445_07695	COG0167	dihydroorotate dehydrogenase activity
NP445_07700	COG0284	orotidine-5'-phosphate decarboxylase activity
NP445_07705	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NP445_07715	COG0175	sulfate reduction
NP445_07720	COG0306	phosphate transporter
NP445_07725	COG2046	Belongs to the sulfate adenylyltransferase family
NP445_07730	COG0529	Catalyzes the synthesis of activated sulfate
NP445_07735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP445_07740	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NP445_07745	COG1648	precorrin-2 dehydrogenase activity
NP445_07755	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NP445_07760	COG1561	YicC-like family, N-terminal region
NP445_07765	COG2052	Domain of unknown function (DUF370)
NP445_07770	COG0194	GDP metabolic process
NP445_07775	COG1758	RNA polymerase activity
NP445_07780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NP445_07785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NP445_07790	COG0242	peptide deformylase activity
NP445_07795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NP445_07800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NP445_07800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NP445_07805	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NP445_07810	COG0631	protein serine/threonine phosphatase activity
NP445_07815	COG0515	serine threonine protein kinase
NP445_07815	COG2815	serine threonine protein kinase
NP445_07820	COG1162	GTPase activity
NP445_07825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NP445_07830	COG1564	THIamine pyrophosphokinase
NP445_07840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NP445_07845	COG1302	Protein conserved in bacteria
NP445_07850	COG1461	Dihydroxyacetone kinase
NP445_07855	COG1760	l-serine dehydratase
NP445_07860	COG1760	l-serine dehydratase
NP445_07865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NP445_07870	COG1349	DNA-binding transcription factor activity
NP445_07875	COG0416	fatty acid biosynthetic process
NP445_07880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NP445_07885	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_07890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NP445_07900	COG1196	nuclear chromosome segregation
NP445_07905	COG0552	protein localization to endoplasmic reticulum
NP445_07910	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NP445_07915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NP445_07920	COG0228	four-way junction DNA binding
NP445_07925	COG1837	Belongs to the UPF0109 family
NP445_07935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NP445_07940	COG0336	Belongs to the RNA methyltransferase TrmD family
NP445_07945	COG0335	large ribosomal subunit rRNA binding
NP445_07950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NP445_07955	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NP445_07965	COG2257	FlhB HrpN YscU SpaS Family
NP445_07970	COG0045	succinate-CoA ligase (ADP-forming) activity
NP445_07975	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NP445_07980	COG0758	DNA mediated transformation
NP445_07985	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP445_07990	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NP445_07995	COG4974	Belongs to the 'phage' integrase family
NP445_08000	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NP445_08005	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NP445_08010	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NP445_08015	COG1815	bacterial-type flagellum-dependent cell motility
NP445_08020	COG1558	bacterial-type flagellum-dependent cell motility
NP445_08025	COG1677	Flagellar hook-basal body complex protein FliE
NP445_08030	COG1766	The M ring may be actively involved in energy transduction
NP445_08035	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP445_08040	COG1317	bacterial-type flagellum organization
NP445_08045	COG1157	protein secretion by the type III secretion system
NP445_08050	COG2882	bacterial-type flagellum organization
NP445_08055	COG3334	PFAM MgtE intracellular
NP445_08060	COG3144	bacterial-type flagellum assembly
NP445_08065	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NP445_08070	COG4786	Flagellar basal body rod
NP445_08075	COG1582	Flagellar protein (FlbD)
NP445_08080	COG1580	Controls the rotational direction of flagella during chemotaxis
NP445_08085	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP445_08090	COG1776	CheC inhibitor of MCP methylation
NP445_08090	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP445_08095	COG2201	protein-glutamate methylesterase activity
NP445_08100	COG3190	flagellar
NP445_08105	COG1338	Plays a role in the flagellum-specific transport system
NP445_08110	COG1987	bacterial-type flagellum assembly
NP445_08115	COG1684	flagellar biosynthetic protein fliR
NP445_08120	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NP445_08125	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NP445_08130	COG1419	protein localization to endoplasmic reticulum
NP445_08135	COG0455	bacterial-type flagellum organization
NP445_08140	COG2201	protein-glutamate methylesterase activity
NP445_08145	COG2198	Histidine kinase
NP445_08145	COG0643	Histidine kinase
NP445_08150	COG0835	chemotaxis
NP445_08155	COG1776	CheC inhibitor of MCP methylation
NP445_08165	COG1191	sigma factor activity
NP445_08180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NP445_08185	COG0528	UMP kinase activity
NP445_08190	COG0233	cytoplasmic translational termination
NP445_08195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NP445_08200	COG4589	Belongs to the CDS family
NP445_08205	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NP445_08210	COG0750	zinc metalloprotease
NP445_08215	COG0442	prolyl-tRNA aminoacylation
NP445_08220	COG2176	DNA-directed DNA polymerase activity
NP445_08235	COG3693	PFAM glycoside hydrolase, family 10
NP445_08245	COG0779	Required for maturation of 30S ribosomal subunits
NP445_08250	COG0195	Participates in both transcription termination and antitermination
NP445_08255	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NP445_08260	COG1358	cellular component organization or biogenesis
NP445_08270	COG1550	Protein conserved in bacteria
NP445_08275	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NP445_08280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NP445_08285	COG0196	riboflavin kinase activity
NP445_08290	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NP445_08295	COG1185	polyribonucleotide nucleotidyltransferase activity
NP445_08300	COG0726	polysaccharide deacetylase
NP445_08305	COG0612	Peptidase, M16
NP445_08315	COG1873	PFAM PRC-barrel domain
NP445_08320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP445_08325	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NP445_08330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NP445_08335	COG0527	aspartate kinase activity
NP445_08345	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NP445_08350	COG0740	serine-type endopeptidase activity
NP445_08360	COG1674	ftsk spoiiie
NP445_08360	COG4980	gas vesicle protein
NP445_08365	COG2188	Transcriptional regulator
NP445_08370	COG2814	Major facilitator Superfamily
NP445_08375	COG1033	growth of symbiont in host cell
NP445_08375	COG2409	Drug exporters of the RND superfamily
NP445_08380	COG0612	Peptidase, M16
NP445_08385	COG0612	Peptidase, M16
NP445_08395	COG1033	growth of symbiont in host cell
NP445_08395	COG2409	Drug exporters of the RND superfamily
NP445_08400	COG0300	oxidoreductase activity
NP445_08415	COG1426	Protein conserved in bacteria
NP445_08420	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NP445_08425	COG1058	Belongs to the CinA family
NP445_08425	COG1546	Belongs to the CinA family
NP445_08430	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NP445_08435	COG1418	mRNA catabolic process
NP445_08440	COG1692	metallophosphoesterase
NP445_08445	COG2359	stage V sporulation protein S
NP445_08450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NP445_08455	COG1063	alcohol dehydrogenase
NP445_08460	COG0156	8-amino-7-oxononanoate synthase activity
NP445_08465	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NP445_08470	COG4550	Control of competence regulator ComK, YlbF/YmcA
NP445_08480	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NP445_08485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NP445_08505	COG1329	Transcriptional regulator
NP445_08510	COG4195	phage-related replication protein
NP445_08515	COG0457	Tetratricopeptide repeat
NP445_08520	COG1404	Belongs to the peptidase S8 family
NP445_08525	COG4195	phage-related replication protein
NP445_08530	COG1764	response to oxidative stress
NP445_08535	COG2076	Multidrug Resistance protein
NP445_08560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NP445_08565	COG1923	regulation of RNA biosynthetic process
NP445_08580	COG1780	Probably involved in ribonucleotide reductase function
NP445_08585	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NP445_08590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NP445_08595	COG4112	unkown
NP445_08605	COG0464	growth
NP445_08610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NP445_08615	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NP445_08620	COG0789	Transcriptional regulator
NP445_08625	COG0174	glutamine synthetase
NP445_08645	COG0494	nUDIX hydrolase
NP445_08650	COG0457	Tetratricopeptide repeat
NP445_08665	COG5444	nuclease activity
NP445_08690	COG5646	InterPro IPR014922
NP445_08710	COG0457	Tetratricopeptide repeat
NP445_08720	COG3619	membrane
NP445_08725	COG1793	dna ligase
NP445_08725	COG3285	dna ligase
NP445_08730	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NP445_08735	COG4876	unkown
NP445_08745	COG1959	2 iron, 2 sulfur cluster binding
NP445_08750	COG0702	epimerase
NP445_08755	COG0247	lactate metabolic process
NP445_08760	COG1139	Iron-sulfur cluster binding protein
NP445_08765	COG1556	Lactate utilization protein
NP445_08785	COG2323	membrane
NP445_08790	COG1309	transcriptional regulator
NP445_08795	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP445_08795	COG2124	cytochrome p450
NP445_08800	COG3591	Belongs to the peptidase S1B family
NP445_08805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NP445_08810	COG3209	COG3209 Rhs family protein
NP445_08815	COG1366	Belongs to the anti-sigma-factor antagonist family
NP445_08830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NP445_08835	COG1388	LysM domain
NP445_08840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NP445_08845	COG4224	UPF0291 protein
NP445_08850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NP445_08860	COG3763	UPF0154 protein
NP445_08870	COG0785	Cytochrome C biogenesis protein
NP445_08875	COG4846	Membrane protein involved in cytochrome C biogenesis
NP445_08885	COG0071	Belongs to the small heat shock protein (HSP20) family
NP445_08900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NP445_08905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP445_08925	COG0824	Thioesterase
NP445_08935	COG4841	protein insertion into membrane
NP445_08940	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NP445_08945	COG1832	CoA-binding protein
NP445_08950	COG0187	DNA topoisomerase II activity
NP445_08955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NP445_08970	COG0738	Major facilitator superfamily
NP445_08975	COG0473	3-isopropylmalate dehydrogenase activity
NP445_08980	COG0110	maltose O-acetyltransferase activity
NP445_08990	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NP445_08995	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NP445_09005	COG1309	transcriptional regulator
NP445_09010	COG2249	NAD(P)H dehydrogenase (quinone) activity
NP445_09015	COG1733	regulation of RNA biosynthetic process
NP445_09025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP445_09030	COG0251	oxidation-reduction process
NP445_09070	COG0657	acetylesterase activity
NP445_09075	COG0789	Transcriptional regulator
NP445_09085	COG2205	protein histidine kinase activity
NP445_09090	COG0745	RESPONSE REGULATOR receiver
NP445_09100	COG3507	Belongs to the glycosyl hydrolase 43 family
NP445_09105	COG1012	belongs to the aldehyde dehydrogenase family
NP445_09110	COG1486	melibiose metabolic process
NP445_09115	COG0395	ABC-type sugar transport system, permease component
NP445_09120	COG1175	transmembrane transport
NP445_09125	COG1653	transport
NP445_09130	COG1609	Transcriptional regulator
NP445_09135	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NP445_09150	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP445_09165	COG5444	nuclease activity
NP445_09170	COG1846	Transcriptional regulator
NP445_09175	COG2814	Major facilitator Superfamily
NP445_09185	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP445_09185	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP445_09185	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP445_09190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP445_09190	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP445_09190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP445_09195	COG1105	Belongs to the carbohydrate kinase PfkB family
NP445_09205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP445_09230	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP445_09235	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP445_09240	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP445_09245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP445_09250	COG1024	Enoyl-CoA hydratase
NP445_09255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP445_09260	COG0511	ligase activity, forming carbon-carbon bonds
NP445_09265	COG0439	Biotin carboxylase
NP445_09270	COG0318	PFAM AMP-dependent synthetase and ligase
NP445_09275	COG1960	acyl-CoA dehydrogenase activity
NP445_09280	COG1649	PFAM Uncharacterised BCR, COG1649
NP445_09285	COG2365	Tyrosine phosphatase family
NP445_09290	COG1349	DNA-binding transcription factor activity
NP445_09295	COG1942	4-Oxalocrotonate Tautomerase
NP445_09305	COG3835	regulator
NP445_09310	COG0277	FAD linked oxidase domain protein
NP445_09315	COG0247	lactate metabolic process
NP445_09335	COG0166	Belongs to the GPI family
NP445_09340	COG2246	polysaccharide biosynthetic process
NP445_09345	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NP445_09350	COG0586	Pfam SNARE associated Golgi protein
NP445_09355	COG1587	Uroporphyrinogen-III synthase
NP445_09365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP445_09385	COG0534	Mate efflux family protein
NP445_09390	COG2027	D-alanyl-D-alanine carboxypeptidase
NP445_09395	COG4677	pectinesterase activity
NP445_09400	COG2323	membrane
NP445_09405	COG2146	nitrite reductase [NAD(P)H] activity
NP445_09410	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP445_09415	COG0243	molybdopterin cofactor binding
NP445_09420	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP445_09425	COG2223	nitrite transmembrane transporter activity
NP445_09430	COG0493	'glutamate synthase
NP445_09435	COG0067	glutamate synthase
NP445_09435	COG0069	glutamate synthase activity
NP445_09435	COG0070	glutamate synthase
NP445_09440	COG0583	DNA-binding transcription factor activity
NP445_09450	COG1132	(ABC) transporter
NP445_09455	COG0789	Transcriptional regulator
NP445_09455	COG4978	Transcriptional regulator
NP445_09460	COG0454	-acetyltransferase
NP445_09465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NP445_09470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NP445_09475	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP445_09485	COG0243	molybdopterin cofactor binding
NP445_09495	COG1070	Carbohydrate kinase
NP445_09500	COG2115	Belongs to the xylose isomerase family
NP445_09505	COG1940	carbohydrate kinase activity
NP445_09515	COG2211	Major facilitator Superfamily
NP445_09520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP445_09525	COG1994	Peptidase M50
NP445_09545	COG1309	transcriptional regulator
NP445_09550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP445_09555	COG3708	Transcriptional regulator
NP445_09560	COG2378	regulation of single-species biofilm formation
NP445_09570	COG0640	Transcriptional regulator
NP445_09575	COG0531	amino acid
NP445_09580	COG0741	lytic transglycosylase activity
NP445_09585	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NP445_09590	COG2079	MmgE PrpD family protein
NP445_09595	COG0372	Belongs to the citrate synthase family
NP445_09600	COG2322	membrane
NP445_09610	COG1388	LysM domain
NP445_09610	COG3584	3D domain protein
NP445_09615	COG0514	ATP-dependent DNA helicase (RecQ)
NP445_09625	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP445_09650	COG1012	belongs to the aldehyde dehydrogenase family
NP445_09655	COG1657	PFAM Prenyltransferase squalene oxidase
NP445_09660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NP445_09665	COG0385	Bile acid
NP445_09670	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP445_09675	COG0567	Dehydrogenase, E1 component
NP445_09680	COG4548	von Willebrand factor, type A
NP445_09685	COG0714	Associated with various cellular activities
NP445_09690	COG2032	superoxide dismutase activity
NP445_09695	COG0791	NLP P60 protein
NP445_09695	COG1388	LysM domain
NP445_09700	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NP445_09710	COG0534	Mate efflux family protein
NP445_09715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP445_09720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP445_09730	COG2962	Rard protein
NP445_09745	COG1733	regulation of RNA biosynthetic process
NP445_09750	COG0778	Nitroreductase
NP445_09760	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP445_09765	COG0793	Belongs to the peptidase S41A family
NP445_09765	COG3409	Peptidoglycan-binding domain 1 protein
NP445_09770	COG2226	methyltransferase
NP445_09780	COG1876	peptidase activity
NP445_09785	COG0813	purine-nucleoside phosphorylase activity
NP445_09795	COG0671	phosphoesterase, PA-phosphatase related
NP445_09815	COG4479	Belongs to the UPF0346 family
NP445_09825	COG1509	lysine 2,3-aminomutase activity
NP445_09830	COG3829	transcription factor binding
NP445_09835	COG0463	Glycosyl transferase, family 2
NP445_09850	COG4641	Protein conserved in bacteria
NP445_09860	COG1086	Polysaccharide biosynthesis protein
NP445_09865	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP445_09870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP445_09875	COG1846	Transcriptional regulator
NP445_09895	COG4698	Protein conserved in bacteria
NP445_09900	COG2755	lipolytic protein G-D-S-L family
NP445_09905	COG1999	signal sequence binding
NP445_09920	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NP445_09925	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NP445_09930	COG1272	protein, Hemolysin III
NP445_09935	COG0204	Acyl-transferase
NP445_09940	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP445_09945	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NP445_09950	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NP445_09960	COG2136	Putative SAM-dependent methyltransferase
NP445_09960	COG2521	methyltransferase
NP445_09975	COG1413	lyase activity
NP445_09980	COG1418	mRNA catabolic process
NP445_09985	COG0386	Belongs to the glutathione peroxidase family
NP445_09990	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NP445_09995	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NP445_10000	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP445_10010	COG1278	Cold shock
NP445_10025	COG0328	RNA-DNA hybrid ribonuclease activity
NP445_10030	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NP445_10035	COG0328	RNA-DNA hybrid ribonuclease activity
NP445_10045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP445_10055	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NP445_10060	COG1755	Isoprenylcysteine carboxyl methyltransferase
NP445_10065	COG3424	synthase
NP445_10070	COG0726	polysaccharide deacetylase
NP445_10075	COG2233	PERMEase
NP445_10080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP445_10085	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NP445_10090	COG1199	ATP-dependent helicase activity
NP445_10100	COG0116	Belongs to the methyltransferase superfamily
NP445_10110	COG3599	regulation of cell shape
NP445_10115	COG4474	Belongs to the UPF0398 family
NP445_10125	COG3359	exonuclease
NP445_10130	COG1111	helicase
NP445_10130	COG1205	dead DEAH box helicase
NP445_10135	COG1902	pentaerythritol trinitrate reductase activity
NP445_10140	COG2190	(PTS) system
NP445_10145	COG0071	Belongs to the small heat shock protein (HSP20) family
NP445_10175	COG3331	DNA recombination
NP445_10180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP445_10180	COG4499	WXG100 protein secretion system (Wss), protein YukC
NP445_10190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NP445_10195	COG3935	DnaD domain protein
NP445_10200	COG0017	Asparaginyl-tRNA synthetase
NP445_10205	COG5353	protein conserved in bacteria
NP445_10215	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NP445_10215	COG1199	ATP-dependent helicase activity
NP445_10220	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NP445_10225	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NP445_10230	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NP445_10240	COG0617	tRNA 3'-terminal CCA addition
NP445_10245	COG0438	transferase activity, transferring glycosyl groups
NP445_10250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP445_10255	COG1803	Methylglyoxal synthase
NP445_10260	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NP445_10265	COG1694	Mazg nucleotide pyrophosphohydrolase
NP445_10270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP445_10280	COG4347	Protein of unknown function (DUF1405)
NP445_10285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NP445_10285	COG2010	Cytochrome c
NP445_10290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NP445_10295	COG0723	plastoquinol--plastocyanin reductase activity
NP445_10305	COG5582	Belongs to the UPF0302 family
NP445_10310	COG0457	Tetratricopeptide repeat
NP445_10315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NP445_10320	COG0287	Prephenate dehydrogenase
NP445_10325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NP445_10330	COG0159	tryptophan synthase activity
NP445_10335	COG0133	tryptophan synthase activity
NP445_10345	COG0134	indole-3-glycerol-phosphate synthase activity
NP445_10350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NP445_10360	COG4401	Chorismate mutase type I
NP445_10365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NP445_10370	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NP445_10375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NP445_10380	COG0105	UTP biosynthetic process
NP445_10385	COG0142	geranyltranstransferase activity
NP445_10390	COG2226	methyltransferase
NP445_10395	COG0142	geranyltranstransferase activity
NP445_10405	COG0302	gtp cyclohydrolase
NP445_10410	COG0776	regulation of translation
NP445_10415	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NP445_10430	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NP445_10435	COG1160	GTP binding
NP445_10460	COG1304	FMN binding
NP445_10465	COG0539	negative regulation of cytoplasmic translation
NP445_10470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NP445_10480	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
NP445_10485	COG2959	enzyme of heme biosynthesis
NP445_10490	COG3409	Peptidoglycan-binding domain 1 protein
NP445_10490	COG3773	Cell wall hydrolase
NP445_10495	COG2339	peptidase activity
NP445_10500	COG0492	ferredoxin-NADP+ reductase activity
NP445_10505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP445_10510	COG4862	establishment of competence for transformation
NP445_10515	COG1408	metallophosphoesterase
NP445_10525	COG1388	LysM domain
NP445_10530	COG1266	CAAX protease self-immunity
NP445_10535	COG0514	ATP-dependent DNA helicase (RecQ)
NP445_10540	COG4955	Helix-turn-helix domain
NP445_10545	COG1141	Ferredoxin
NP445_10550	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NP445_10555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NP445_10570	COG1595	DNA-templated transcription, initiation
NP445_10575	COG5002	protein histidine kinase activity
NP445_10580	COG0745	RESPONSE REGULATOR receiver
NP445_10585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP445_10590	COG1333	cytochrome c biogenesis protein
NP445_10595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP445_10600	COG1187	pseudouridine synthase activity
NP445_10605	COG0700	Nucleoside recognition
NP445_10610	COG2715	membrane protein required for spore maturation
NP445_10615	COG1686	Belongs to the peptidase S11 family
NP445_10625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NP445_10630	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NP445_10640	COG1547	Domain of unknown function (DUF309)
NP445_10645	COG0456	acetyltransferase
NP445_10650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NP445_10660	COG0307	riboflavin synthase, alpha
NP445_10680	COG2814	Major facilitator Superfamily
NP445_10685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NP445_10690	COG4086	secreted protein
NP445_10695	COG0019	diaminopimelate decarboxylase activity
NP445_10700	COG0697	spore germination
NP445_10715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP445_10735	COG1191	sigma factor activity
NP445_10740	COG2172	sigma factor antagonist activity
NP445_10750	COG1686	Belongs to the peptidase S11 family
NP445_10755	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NP445_10760	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NP445_10765	COG4974	Belongs to the 'phage' integrase family
NP445_10775	COG0735	belongs to the Fur family
NP445_10780	COG1300	Membrane
NP445_10785	COG1404	Belongs to the peptidase S8 family
NP445_10795	COG2153	protein acetylation
NP445_10800	COG1379	DNA repair
NP445_10805	COG0494	nUDIX hydrolase
NP445_10810	COG0667	Aldo Keto reductase
NP445_10825	COG1073	alpha beta
NP445_10830	COG0457	Tetratricopeptide repeat
NP445_10840	COG4918	Iron-sulphur cluster biosynthesis
NP445_10845	COG4305	rare lipoprotein A
NP445_10850	COG0456	acetyltransferase
NP445_10850	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NP445_10855	COG0456	acetyltransferase
NP445_10865	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP445_10875	COG2211	Major facilitator Superfamily
NP445_10880	COG1072	(Pantothenic acid kinase))
NP445_10885	COG0446	pyridine nucleotide-disulphide oxidoreductase
NP445_10895	COG0300	oxidoreductase activity
NP445_10900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP445_10905	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP445_10915	COG4187	Peptidase family M20/M25/M40
NP445_10920	COG1902	pentaerythritol trinitrate reductase activity
NP445_10925	COG0596	Alpha beta hydrolase
NP445_10930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP445_10940	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NP445_10945	COG2188	Transcriptional regulator
NP445_10950	COG2723	6-phospho-beta-galactosidase activity
NP445_10955	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP445_10960	COG1447	Phosphotransferase system cellobiose-specific component IIA
NP445_10965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP445_10970	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_10980	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NP445_10985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP445_10995	COG0706	membrane insertase activity
NP445_11000	COG0835	chemotaxis
NP445_11005	COG2195	Cleaves the N-terminal amino acid of tripeptides
NP445_11010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP445_11015	COG0346	lactoylglutathione lyase activity
NP445_11025	COG1376	ErfK ybiS ycfS ynhG family protein
NP445_11030	COG4129	membrane
NP445_11035	COG1126	abc transporter atp-binding protein
NP445_11040	COG0765	amino acid transport
NP445_11045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP445_11055	COG1597	lipid kinase activity
NP445_11065	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP445_11070	COG0022	dehydrogenase e1 component
NP445_11075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP445_11080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP445_11085	COG3426	butyrate kinase activity
NP445_11090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP445_11095	COG0280	phosphate acetyltransferase
NP445_11100	COG3290	protein histidine kinase activity
NP445_11100	COG3829	transcription factor binding
NP445_11110	COG0584	glycerophosphoryl diester phosphodiesterase
NP445_11115	COG0457	Tetratricopeptide repeat
NP445_11120	COG0745	RESPONSE REGULATOR receiver
NP445_11125	COG0750	zinc metalloprotease
NP445_11130	COG0497	DNA recombination
NP445_11135	COG1438	arginine binding
NP445_11140	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NP445_11145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NP445_11150	COG0142	geranyltranstransferase activity
NP445_11155	COG1722	exodeoxyribonuclease VII activity
NP445_11160	COG1570	exodeoxyribonuclease VII activity
NP445_11165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NP445_11170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NP445_11175	COG1302	Protein conserved in bacteria
NP445_11180	COG0439	Biotin carboxylase
NP445_11185	COG0511	ligase activity, forming carbon-carbon bonds
NP445_11225	COG3854	ATPases associated with a variety of cellular activities
NP445_11235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NP445_11240	COG0006	proline dipeptidase activity
NP445_11245	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NP445_11255	COG3872	metal-dependent enzyme
NP445_11265	COG1752	Esterase of the alpha-beta hydrolase superfamily
NP445_11270	COG1321	iron dependent repressor
NP445_11275	COG0095	Lipoate-protein ligase
NP445_11280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP445_11285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NP445_11290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NP445_11295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NP445_11300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NP445_11325	COG0681	Belongs to the peptidase S26 family
NP445_11360	COG4970	Tfp pilus assembly protein FimT
NP445_11365	COG4537	Required for transformation and DNA binding
NP445_11370	COG1459	type II secretion system
NP445_11375	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NP445_11380	COG1366	Belongs to the anti-sigma-factor antagonist family
NP445_11390	COG1393	Belongs to the ArsC family
NP445_11400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP445_11410	COG0011	TIGRFAM Protein of
NP445_11415	COG2814	Major facilitator Superfamily
NP445_11420	COG2866	Carboxypeptidase
NP445_11425	COG1368	sulfuric ester hydrolase activity
NP445_11430	COG1940	carbohydrate kinase activity
NP445_11435	COG4483	Protein conserved in bacteria
NP445_11440	COG0457	Tetratricopeptide repeat
NP445_11440	COG0705	Rhomboid family
NP445_11455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NP445_11460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NP445_11470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NP445_11475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP445_11480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP445_11485	COG0581	inorganic phosphate transmembrane transporter activity
NP445_11490	COG0573	inorganic phosphate transmembrane transporter activity
NP445_11495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NP445_11500	COG0768	penicillin binding
NP445_11505	COG0477	Major facilitator Superfamily
NP445_11510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NP445_11515	COG2839	Protein conserved in bacteria
NP445_11520	COG5521	maltodextrose utilization protein MalA
NP445_11525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP445_11530	COG1388	LysM domain
NP445_11535	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NP445_11540	COG4709	membrane
NP445_11545	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
NP445_11550	COG1940	carbohydrate kinase activity
NP445_11555	COG0735	belongs to the Fur family
NP445_11560	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP445_11565	COG1121	(ABC) transporter
NP445_11570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP445_11585	COG0513	Belongs to the DEAD box helicase family
NP445_11595	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NP445_11600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NP445_11605	COG2384	SAM-dependent methyltransferase
NP445_11610	COG2010	Cytochrome c
NP445_11615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NP445_11620	COG0358	DNA primase activity
NP445_11625	COG1671	Belongs to the UPF0178 family
NP445_11630	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NP445_11635	COG0517	IMP dehydrogenase activity
NP445_11640	COG0751	glycine-tRNA ligase activity
NP445_11645	COG0752	glycyl-tRNA synthetase alpha subunit
NP445_11650	COG1381	Involved in DNA repair and RecF pathway recombination
NP445_11660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NP445_11665	COG0295	cytidine deaminase activity
NP445_11670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NP445_11675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NP445_11680	COG1480	7TM receptor with intracellular HD hydrolase
NP445_11685	COG1702	phosphate starvation-inducible protein PhoH
NP445_11690	COG0561	phosphatase activity
NP445_11705	COG4864	UPF0365 protein
NP445_11710	COG1030	water channel activity
NP445_11715	COG1610	YqeY-like protein
NP445_11725	COG1283	sodium-dependent phosphate transmembrane transporter activity
NP445_11730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NP445_11735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NP445_11740	COG2264	protein methyltransferase activity
NP445_11745	COG0484	heat shock protein binding
NP445_11755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NP445_11760	COG1420	regulation of RNA biosynthetic process
NP445_11765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NP445_11770	COG0481	GTPase activity
NP445_11780	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP445_11785	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NP445_11790	COG0268	Binds directly to 16S ribosomal RNA
NP445_11795	COG1466	dna polymerase III delta subunit
NP445_11805	COG2333	competence protein COMEC
NP445_11805	COG0658	competence protein
NP445_11810	COG2131	deaminase
NP445_11815	COG1555	photosystem II stabilization
NP445_11815	COG1596	polysaccharide export
NP445_11820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP445_11825	COG2226	methyltransferase
NP445_11830	COG0799	negative regulation of ribosome biogenesis
NP445_11835	COG1713	HD superfamily hydrolase involved in NAD metabolism
NP445_11840	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NP445_11845	COG1534	Rna-binding protein
NP445_11850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NP445_11855	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NP445_11860	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NP445_11875	COG2755	lipolytic protein G-D-S-L family
NP445_11885	COG0457	Tetratricopeptide repeat
NP445_11910	COG0726	polysaccharide deacetylase
NP445_11945	COG1131	(ABC) transporter
NP445_11970	COG2160	L-arabinose isomerase activity
NP445_11985	COG1609	Transcriptional regulator
NP445_11995	COG1846	Transcriptional regulator
NP445_12005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NP445_12010	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NP445_12015	COG1733	regulation of RNA biosynthetic process
NP445_12020	COG0657	acetylesterase activity
NP445_12085	COG2602	Beta-lactamase
NP445_12090	COG1960	acyl-CoA dehydrogenase activity
NP445_12095	COG1126	abc transporter atp-binding protein
NP445_12100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP445_12105	COG0765	amino acid transport
NP445_12115	COG3546	catalase activity
NP445_12120	COG1063	alcohol dehydrogenase
NP445_12130	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_12140	COG0583	DNA-binding transcription factor activity
NP445_12145	COG0842	Transport permease protein
NP445_12150	COG0842	Transport permease protein
NP445_12150	COG1511	domain protein
NP445_12155	COG1131	(ABC) transporter
NP445_12160	COG1063	alcohol dehydrogenase
NP445_12165	COG2226	methyltransferase
NP445_12190	COG0626	cystathionine gamma-synthase activity
NP445_12195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP445_12200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NP445_12205	COG2226	methyltransferase
NP445_12220	COG0768	penicillin binding
NP445_12225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NP445_12230	COG0572	uridine kinase
NP445_12235	COG0826	peptidase U32
NP445_12240	COG0826	peptidase U32
NP445_12245	COG4122	O-methyltransferase activity
NP445_12250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NP445_12255	COG0183	Belongs to the thiolase family
NP445_12260	COG0318	PFAM AMP-dependent synthetase and ligase
NP445_12265	COG1268	BioY protein
NP445_12270	COG3906	Belongs to the UPF0473 family
NP445_12275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NP445_12280	COG4472	Bacterial protein of unknown function (DUF965)
NP445_12285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NP445_12290	COG0628	permease
NP445_12300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP445_12305	COG0765	amino acid transport
NP445_12310	COG0765	amino acid transport
NP445_12325	COG3881	PFAM PRC-barrel domain
NP445_12330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NP445_12335	COG0457	Tetratricopeptide repeat
NP445_12340	COG0482	sulfurtransferase activity
NP445_12345	COG1104	cysteine desulfurase activity
NP445_12350	COG1959	2 iron, 2 sulfur cluster binding
NP445_12355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NP445_12360	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NP445_12375	COG0124	histidyl-tRNA synthetase
NP445_12385	COG4991	sh3 domain protein
NP445_12385	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP445_12385	COG3103	Sh3 type 3 domain protein
NP445_12390	COG1490	D-aminoacyl-tRNA deacylase activity
NP445_12395	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NP445_12400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP445_12405	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NP445_12405	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NP445_12410	COG5416	Lipopolysaccharide assembly protein A domain
NP445_12415	COG0490	domain, Protein
NP445_12420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP445_12420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP445_12430	COG2244	polysaccharide biosynthetic process
NP445_12435	COG2323	membrane
NP445_12445	COG1862	Preprotein translocase
NP445_12450	COG0343	queuine tRNA-ribosyltransferase activity
NP445_12455	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NP445_12465	COG2255	four-way junction helicase activity
NP445_12470	COG0632	four-way junction helicase activity
NP445_12480	COG2112	serine threonine protein kinase
NP445_12495	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NP445_12510	COG1388	LysM domain
NP445_12515	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NP445_12520	COG0157	Belongs to the NadC ModD family
NP445_12525	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NP445_12530	COG1104	cysteine desulfurase activity
NP445_12535	COG1827	regulation of RNA biosynthetic process
NP445_12540	COG0077	Prephenate dehydratase
NP445_12545	COG4492	Belongs to the UPF0735 family
NP445_12550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NP445_12555	COG3290	protein histidine kinase activity
NP445_12560	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NP445_12565	COG2868	ribosomal protein
NP445_12570	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NP445_12575	COG1994	Peptidase M50
NP445_12580	COG0739	heme binding
NP445_12585	COG2894	cell division
NP445_12590	COG0850	regulation of cytokinetic process
NP445_12595	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NP445_12605	COG1077	Cell shape determining protein MreB Mrl
NP445_12610	COG2003	Belongs to the UPF0758 family
NP445_12615	COG0424	maF-like protein
NP445_12630	COG0285	dihydrofolate synthase activity
NP445_12635	COG0525	valine-tRNA ligase activity
NP445_12645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP445_12650	COG1388	LysM domain
NP445_12655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NP445_12660	COG0113	porphobilinogen synthase activity
NP445_12665	COG1587	Uroporphyrinogen-III synthase
NP445_12670	COG0181	hydroxymethylbilane synthase activity
NP445_12675	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP445_12680	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NP445_12690	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NP445_12695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NP445_12700	COG0470	DNA polymerase III
NP445_12700	COG1067	ATP-dependent peptidase activity
NP445_12705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NP445_12710	COG0544	peptidyl-prolyl cis-trans isomerase activity
NP445_12715	COG1477	protein flavinylation
NP445_12715	COG0457	Tetratricopeptide repeat
NP445_12720	COG0066	3-isopropylmalate dehydratase activity
NP445_12725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NP445_12730	COG0473	3-isopropylmalate dehydrogenase activity
NP445_12735	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP445_12740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NP445_12745	COG0440	acetolactate synthase activity
NP445_12750	COG0028	Belongs to the TPP enzyme family
NP445_12755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP445_12760	COG2706	6-phosphogluconolactonase activity
NP445_12765	COG3339	Conserved Protein
NP445_12770	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NP445_12775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NP445_12780	COG1696	Membrane protein involved in D-alanine export
NP445_12785	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP445_12800	COG5444	nuclease activity
NP445_12820	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
NP445_12825	COG5444	nuclease activity
NP445_12840	COG0622	Phosphoesterase
NP445_12845	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NP445_12850	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NP445_12855	COG5401	PFAM Sporulation and spore germination
NP445_12860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NP445_12865	COG1846	Transcriptional regulator
NP445_12870	COG2197	response regulator
NP445_12875	COG2851	Citrate transporter
NP445_12880	COG0583	DNA-binding transcription factor activity
NP445_12885	COG2828	Protein conserved in bacteria
NP445_12895	COG0824	Thioesterase
NP445_12900	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NP445_12905	COG1053	succinate dehydrogenase
NP445_12910	COG2009	succinate dehydrogenase
NP445_12915	COG1719	4-vinyl reductase, 4VR
NP445_12920	COG0527	aspartate kinase activity
NP445_12925	COG0322	excinuclease ABC activity
NP445_12930	COG3118	belongs to the thioredoxin family
NP445_12935	COG3534	alpha-L-arabinofuranosidase
NP445_12940	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NP445_12945	COG2086	electron transfer activity
NP445_12950	COG1024	Enoyl-CoA hydratase
NP445_12955	COG1309	transcriptional regulator
NP445_12960	COG0318	PFAM AMP-dependent synthetase and ligase
NP445_12970	COG3766	membrane
NP445_12975	COG1193	negative regulation of DNA recombination
NP445_12980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NP445_12980	COG1796	DNA polymerase
NP445_12985	COG1286	toxin biosynthetic process
NP445_12990	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NP445_12995	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NP445_13000	COG0072	phenylalanine-tRNA ligase activity
NP445_13000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP445_13005	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NP445_13010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP445_13020	COG1966	Carbon starvation protein
NP445_13025	COG1363	Peptidase, m42
NP445_13035	COG3326	Membrane
NP445_13040	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NP445_13045	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NP445_13050	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NP445_13060	COG1011	Hydrolase
NP445_13070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NP445_13080	COG0398	Pfam SNARE associated Golgi protein
NP445_13085	COG1484	DNA-dependent DNA replication
NP445_13090	COG3611	Membrane attachment protein
NP445_13095	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NP445_13105	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NP445_13110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP445_13115	COG0237	dephospho-CoA kinase activity
NP445_13120	COG1971	Probably functions as a manganese efflux pump
NP445_13130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP445_13130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP445_13135	COG5002	protein histidine kinase activity
NP445_13140	COG0745	RESPONSE REGULATOR receiver
NP445_13145	COG0039	L-malate dehydrogenase activity
NP445_13150	COG0538	isocitrate dehydrogenase activity
NP445_13160	COG2707	UPF0756 membrane protein
NP445_13165	COG0628	permease
NP445_13170	COG3030	protein affecting phage T7 exclusion by the F plasmid
NP445_13180	COG0205	6-phosphofructokinase activity
NP445_13185	COG0825	malonyl-CoA metabolic process
NP445_13190	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NP445_13195	COG0281	malic enzyme
NP445_13200	COG0587	DNA-directed DNA polymerase activity
NP445_13220	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NP445_13230	COG4109	DRTGG domain
NP445_13235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NP445_13240	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_13250	COG0165	Argininosuccinate lyase
NP445_13255	COG0137	argininosuccinate synthase activity
NP445_13260	COG0521	Mo-molybdopterin cofactor biosynthetic process
NP445_13265	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NP445_13270	COG0827	DNA restriction-modification system
NP445_13275	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NP445_13280	COG3874	Sporulation protein YtfJ
NP445_13290	COG1714	RDD family
NP445_13295	COG0616	signal peptide processing
NP445_13300	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NP445_13310	COG3239	Fatty acid desaturase
NP445_13315	COG4585	Histidine kinase
NP445_13320	COG2197	response regulator
NP445_13325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP445_13330	COG0745	RESPONSE REGULATOR receiver
NP445_13335	COG2205	protein histidine kinase activity
NP445_13340	COG0772	Belongs to the SEDS family
NP445_13345	COG1695	Transcriptional regulator
NP445_13350	COG1136	(ABC) transporter
NP445_13355	COG0577	efflux transmembrane transporter activity
NP445_13360	COG0402	S-adenosylhomocysteine deaminase activity
NP445_13365	COG2249	NAD(P)H dehydrogenase (quinone) activity
NP445_13385	COG1279	arginine transmembrane transporter activity
NP445_13390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP445_13400	COG0301	tRNA thio-modification
NP445_13405	COG1104	cysteine desulfurase activity
NP445_13410	COG1114	Component of the transport system for branched-chain amino acids
NP445_13415	COG1114	Component of the transport system for branched-chain amino acids
NP445_13420	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
NP445_13425	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NP445_13430	COG1309	transcriptional regulator
NP445_13435	COG1956	GAF domain-containing protein
NP445_13440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NP445_13455	COG1335	isochorismatase
NP445_13465	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NP445_13475	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NP445_13480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP445_13485	COG0454	-acetyltransferase
NP445_13490	COG0517	IMP dehydrogenase activity
NP445_13495	COG0123	including yeast histone deacetylase and acetoin utilization protein
NP445_13500	COG1609	Transcriptional regulator
NP445_13505	COG1605	Chorismate mutase
NP445_13505	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NP445_13510	COG3118	belongs to the thioredoxin family
NP445_13515	COG4980	gas vesicle protein
NP445_13520	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NP445_13525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NP445_13530	COG1674	ftsk spoiiie
NP445_13535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP445_13540	COG4848	Belongs to the UPF0354 family
NP445_13545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP445_13560	COG1363	Peptidase, m42
NP445_13565	COG5584	Small secreted protein
NP445_13570	COG0281	malic enzyme
NP445_13575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP445_13580	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NP445_13590	COG0510	thiamine kinase activity
NP445_13595	COG1597	lipid kinase activity
NP445_13605	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NP445_13610	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP445_13615	COG3340	Belongs to the peptidase S51 family
NP445_13620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP445_13625	COG2252	PERMEase
NP445_13630	COG1349	DNA-binding transcription factor activity
NP445_13635	COG1187	pseudouridine synthase activity
NP445_13640	COG2244	polysaccharide biosynthetic process
NP445_13645	COG2081	HI0933 family
NP445_13655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NP445_13660	COG3196	Protein conserved in bacteria
NP445_13670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP445_13675	COG5578	integral membrane protein
NP445_13680	COG0673	inositol 2-dehydrogenase activity
NP445_13685	COG1653	transport
NP445_13690	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NP445_13695	COG4209	transmembrane transport
NP445_13700	COG2207	Transcriptional regulator
NP445_13705	COG1733	regulation of RNA biosynthetic process
NP445_13710	COG2814	Major facilitator Superfamily
NP445_13715	COG0656	L-ascorbic acid biosynthetic process
NP445_13720	COG1653	transport
NP445_13725	COG0395	ABC-type sugar transport system, permease component
NP445_13730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP445_13735	COG1073	alpha beta
NP445_13740	COG0495	leucyl-tRNA aminoacylation
NP445_13750	COG2202	Pas domain
NP445_13750	COG1366	Belongs to the anti-sigma-factor antagonist family
NP445_13755	COG2433	Pfam Transposase IS66
NP445_13760	COG0577	efflux transmembrane transporter activity
NP445_13765	COG1136	(ABC) transporter
NP445_13775	COG1131	(ABC) transporter
NP445_13780	COG1725	Transcriptional regulator
NP445_13800	COG1242	4 iron, 4 sulfur cluster binding
NP445_13805	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NP445_13810	COG4326	sporulation control protein
NP445_13820	COG2267	carboxylic ester hydrolase activity
NP445_13825	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NP445_13830	COG0367	asparagine synthase
NP445_13835	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NP445_13840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NP445_13850	COG1506	peptidase
NP445_13855	COG1233	COG1233 Phytoene dehydrogenase and related
NP445_13875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NP445_13880	COG1116	anion transmembrane transporter activity
NP445_13885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP445_13890	COG0494	nUDIX hydrolase
NP445_13895	COG2310	stress, protein
NP445_13910	COG4824	toxin secretion phage lysis holin
NP445_13920	COG0783	Belongs to the Dps family
NP445_13935	COG1854	S-ribosylhomocysteine lyase activity
NP445_13940	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NP445_13945	COG0288	reversible hydration of carbon dioxide
NP445_13950	COG3443	Belongs to the bacterial solute-binding protein 9 family
NP445_13950	COG0803	Belongs to the bacterial solute-binding protein 9 family
NP445_13960	COG1271	oxidase subunit
NP445_13965	COG1294	oxidase, subunit
NP445_13980	COG4948	Mandelate Racemase Muconate Lactonizing
NP445_13985	COG0318	PFAM AMP-dependent synthetase and ligase
NP445_13990	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NP445_13995	COG0596	Alpha beta hydrolase
NP445_14000	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NP445_14005	COG1169	isochorismate synthase
NP445_14010	COG1575	Belongs to the MenA family. Type 1 subfamily
NP445_14015	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP445_14020	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NP445_14145	COG3859	Proton-coupled thiamine transporter YuaJ
NP445_14150	COG1247	-acetyltransferase
NP445_14155	COG3339	Conserved Protein
NP445_14160	COG0772	Belongs to the SEDS family
NP445_14165	COG0772	Belongs to the SEDS family
NP445_14170	COG2268	Band 7 protein
NP445_14175	COG1585	Membrane protein implicated in regulation of membrane protease activity
NP445_14180	COG2318	DinB family
NP445_14185	COG1454	alcohol dehydrogenase
NP445_14190	COG1012	belongs to the aldehyde dehydrogenase family
NP445_14195	COG1510	regulation of RNA biosynthetic process
NP445_14205	COG0457	Tetratricopeptide repeat
NP445_14210	COG1114	Component of the transport system for branched-chain amino acids
NP445_14220	COG1687	branched-chain amino acid
NP445_14225	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NP445_14230	COG1522	sequence-specific DNA binding
NP445_14235	COG3409	Peptidoglycan-binding domain 1 protein
NP445_14235	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP445_14270	COG3778	Protein conserved in bacteria
NP445_14275	COG3299	homolog of phage Mu protein gp47
NP445_14280	COG3628	GPW Gp25 family protein
NP445_14290	COG4193	domain, Protein
NP445_14295	COG1652	LysM domain
NP445_14300	COG3953	SLT domain
NP445_14300	COG3953	SLT domain
NP445_14300	COG5280	Phage tail tape measure protein TP901
NP445_14300	COG5280	Phage tail tape measure protein TP901
NP445_14360	COG4653	Phage capsid family
NP445_14365	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NP445_14375	COG2369	cell adhesion
NP445_14380	COG5518	Phage portal protein
NP445_14385	COG1783	phage Terminase large subunit
NP445_14430	COG5444	nuclease activity
NP445_14490	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
NP445_14495	COG0305	Participates in initiation and elongation during chromosome replication
NP445_14560	COG1396	sequence-specific DNA binding
NP445_14570	COG2856	Zn peptidase
NP445_14575	COG0582	viral genome integration into host DNA
NP445_14590	COG0789	Transcriptional regulator
NP445_14590	COG4978	Transcriptional regulator
NP445_14595	COG0456	acetyltransferase
NP445_14600	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP445_14600	COG3409	Peptidoglycan-binding domain 1 protein
NP445_14655	COG3778	Protein conserved in bacteria
NP445_14660	COG3299	homolog of phage Mu protein gp47
NP445_14665	COG3628	GPW Gp25 family protein
NP445_14675	COG4193	domain, Protein
NP445_14680	COG1652	LysM domain
NP445_14685	COG3953	SLT domain
NP445_14685	COG5280	Phage tail tape measure protein TP901
NP445_14685	COG3953	SLT domain
NP445_14685	COG5280	Phage tail tape measure protein TP901
NP445_14740	COG4653	Phage capsid family
NP445_14745	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NP445_14750	COG5518	Phage portal protein
NP445_14755	COG1783	phage Terminase large subunit
NP445_14760	COG5484	DNA packaging
NP445_14765	COG1595	DNA-templated transcription, initiation
NP445_14775	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
NP445_14795	COG1396	sequence-specific DNA binding
NP445_14805	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NP445_14820	COG0628	permease
NP445_14830	COG0673	inositol 2-dehydrogenase activity
NP445_14835	COG0693	protein deglycase activity
NP445_14840	COG0840	transmembrane signaling receptor activity
NP445_14845	COG0840	transmembrane signaling receptor activity
NP445_14850	COG0840	transmembrane signaling receptor activity
NP445_14855	COG0840	transmembrane signaling receptor activity
NP445_14870	COG2070	2-Nitropropane dioxygenase
NP445_14875	COG0432	Pfam Uncharacterised protein family UPF0047
NP445_14880	COG1253	flavin adenine dinucleotide binding
NP445_14885	COG2738	Putative neutral zinc metallopeptidase
NP445_14895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NP445_14910	COG0166	Belongs to the GPI family
NP445_14915	COG1979	alcohol dehydrogenase
NP445_14920	COG1979	alcohol dehydrogenase
NP445_14925	COG2155	Conserved Protein
NP445_14930	COG1098	S1 RNA binding domain
NP445_14935	COG0436	Aminotransferase
NP445_14940	COG1522	sequence-specific DNA binding
NP445_14945	COG2267	carboxylic ester hydrolase activity
NP445_14955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NP445_14960	COG2205	protein histidine kinase activity
NP445_14975	COG5018	Exonuclease
NP445_14980	COG2814	Major facilitator Superfamily
NP445_14985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP445_14990	COG3011	Protein conserved in bacteria
NP445_15000	COG3290	protein histidine kinase activity
NP445_15005	COG4565	transcriptional regulatory protein
NP445_15010	COG1744	ABC transporter substrate-binding protein PnrA-like
NP445_15015	COG3845	ABC transporter
NP445_15020	COG4603	Belongs to the binding-protein-dependent transport system permease family
NP445_15025	COG1079	Belongs to the binding-protein-dependent transport system permease family
NP445_15030	COG3493	citrate carrier protein
NP445_15040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NP445_15040	COG2111	Na H antiporter
NP445_15045	COG2111	Na H antiporter
NP445_15050	COG1006	Multisubunit Na H antiporter MnhC subunit
NP445_15055	COG0651	ATP synthesis coupled electron transport
NP445_15060	COG1863	multisubunit Na H antiporter MnhE subunit
NP445_15065	COG2212	antiporter activity
NP445_15070	COG1320	monovalent cation:proton antiporter activity
NP445_15075	COG2050	protein possibly involved in aromatic compounds catabolism
NP445_15080	COG2197	response regulator
NP445_15085	COG4585	Histidine kinase
NP445_15095	COG0142	geranyltranstransferase activity
NP445_15110	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NP445_15115	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NP445_15120	COG1335	isochorismatase
NP445_15125	COG5506	Protein of unknown function (DUF1694)
NP445_15145	COG0628	permease
NP445_15160	COG1418	mRNA catabolic process
NP445_15165	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_15175	COG1511	domain protein
NP445_15180	COG1674	ftsk spoiiie
NP445_15180	COG0433	COG0433 Predicted ATPase
NP445_15185	COG4499	WXG100 protein secretion system (Wss), protein YukC
NP445_15190	COG5417	Belongs to the EsaB family
NP445_15195	COG4842	Belongs to the WXG100 family
NP445_15200	COG2508	Transcriptional regulator
NP445_15200	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NP445_15205	COG0686	Belongs to the AlaDH PNT family
NP445_15210	COG1268	BioY protein
NP445_15215	COG2056	Na+-H+ antiporter family
NP445_15220	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NP445_15225	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NP445_15230	COG3584	3D domain protein
NP445_15245	COG1252	NADH dehydrogenase
NP445_15250	COG0492	ferredoxin-NADP+ reductase activity
NP445_15265	COG0789	Transcriptional regulator
NP445_15270	COG5504	Zn-dependent protease
NP445_15275	COG0316	Belongs to the HesB IscA family
NP445_15280	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NP445_15285	COG4844	belongs to the
NP445_15290	COG1252	NADH dehydrogenase
NP445_15300	COG4837	Protein of unknown function (DUF1462)
NP445_15310	COG0823	Involved in the tonB-independent uptake of proteins
NP445_15310	COG1506	peptidase
NP445_15310	COG4946	Tricorn protease homolog
NP445_15315	COG0083	homoserine kinase activity
NP445_15320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NP445_15325	COG0460	homoserine dehydrogenase
NP445_15330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP445_15335	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP445_15340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NP445_15345	COG0647	UMP catabolic process
NP445_15350	COG2445	Protein of unknown function DUF86
NP445_15355	COG4470	Protein conserved in bacteria
NP445_15365	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NP445_15370	COG0739	heme binding
NP445_15390	COG3377	Domain of unknown function (DUF1805)
NP445_15395	COG0737	Belongs to the 5'-nucleotidase family
NP445_15400	COG1801	Protein of unknown function DUF72
NP445_15405	COG2508	Transcriptional regulator
NP445_15410	COG2140	Oxalate decarboxylase
NP445_15415	COG2814	Major facilitator Superfamily
NP445_15420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NP445_15425	COG2356	endonuclease I
NP445_15440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP445_15445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP445_15450	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP445_15465	COG0561	phosphatase activity
NP445_15475	COG5002	protein histidine kinase activity
NP445_15475	COG0642	Histidine kinase
NP445_15480	COG0745	RESPONSE REGULATOR receiver
NP445_15485	COG2311	Membrane
NP445_15495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NP445_15500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP445_15505	COG1309	transcriptional regulator
NP445_15510	COG0719	Fe-S assembly protein
NP445_15515	COG0822	iron-sulfur transferase activity
NP445_15520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NP445_15525	COG0719	Fe-S assembly protein
NP445_15530	COG0396	ATPase activity
NP445_15540	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NP445_15545	COG1464	Belongs to the NlpA lipoprotein family
NP445_15550	COG2011	ABC-type metal ion transport system permease component
NP445_15555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NP445_15565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP445_15570	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NP445_15580	COG0509	glycine decarboxylation via glycine cleavage system
NP445_15585	COG1393	Belongs to the ArsC family
NP445_15590	COG1960	acyl-CoA dehydrogenase activity
NP445_15595	COG0183	Belongs to the thiolase family
NP445_15600	COG1024	Enoyl-CoA hydratase
NP445_15600	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP445_15615	COG5577	PFAM Coat F domain
NP445_15625	COG1120	ATPase activity
NP445_15635	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_15640	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP445_15645	COG0745	RESPONSE REGULATOR receiver
NP445_15650	COG2205	protein histidine kinase activity
NP445_15650	COG2770	Histidine kinase
NP445_15660	COG1309	transcriptional regulator
NP445_15665	COG0114	fumarate hydratase activity
NP445_15675	COG0697	spore germination
NP445_15680	COG0814	amino acid
NP445_15695	COG2197	response regulator
NP445_15700	COG4585	Histidine kinase
NP445_15705	COG4758	membrane
NP445_15715	COG1842	Phage shock protein A
NP445_15720	COG4758	membrane
NP445_15725	COG2096	Adenosyltransferase
NP445_15730	COG1120	ATPase activity
NP445_15735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP445_15740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP445_15750	COG2721	sulfolactate sulfo-lyase activity
NP445_15755	COG0246	Mannitol dehydrogenase
NP445_15760	COG1609	Transcriptional regulator
NP445_15765	COG1904	glucuronate isomerase
NP445_15770	COG2205	protein histidine kinase activity
NP445_15775	COG0745	RESPONSE REGULATOR receiver
NP445_15780	COG1120	ATPase activity
NP445_15785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP445_15790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP445_15795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP445_15800	COG0531	amino acid
NP445_15815	COG1988	membrane-bound metal-dependent
NP445_15825	COG0725	ABC transporter, periplasmic molybdate-binding protein
NP445_15830	COG4149	molybdate abc transporter
NP445_15835	COG0656	L-ascorbic acid biosynthetic process
NP445_15840	COG1940	carbohydrate kinase activity
NP445_15845	COG0025	NhaP-type Na H and K H
NP445_15850	COG2860	membrane
NP445_15855	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NP445_15860	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NP445_15865	COG2217	Heavy metal translocating P-type atpase
NP445_15870	COG1121	(ABC) transporter
NP445_15875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP445_15880	COG0803	Belongs to the bacterial solute-binding protein 9 family
NP445_15890	COG3226	Transcriptional regulator
NP445_15895	COG0784	Response regulator, receiver
NP445_15900	COG4191	Histidine kinase
NP445_15905	COG1027	Aspartate ammonia-lyase
NP445_15920	COG2217	Heavy metal translocating P-type atpase
NP445_15925	COG2608	mercury ion transmembrane transporter activity
NP445_15930	COG1937	Protein conserved in bacteria
NP445_15960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NP445_15965	COG0557	exoribonuclease II activity
NP445_15970	COG1647	Serine aminopeptidase, S33
NP445_15975	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP445_15980	COG2002	toxin-antitoxin pair type II binding
NP445_15985	COG1476	TRANSCRIPTIONal
NP445_15990	COG1396	sequence-specific DNA binding
NP445_15995	COG1396	sequence-specific DNA binding
NP445_16000	COG1733	regulation of RNA biosynthetic process
NP445_16005	COG1174	glycine betaine transport
NP445_16010	COG1732	Glycine betaine
NP445_16015	COG1174	glycine betaine transport
NP445_16020	COG1125	glycine betaine transport
NP445_16020	COG0517	IMP dehydrogenase activity
NP445_16025	COG1510	regulation of RNA biosynthetic process
NP445_16030	COG2095	MarC family integral membrane protein
NP445_16040	COG0456	acetyltransferase
NP445_16060	COG1131	(ABC) transporter
NP445_16070	COG0148	phosphopyruvate hydratase activity
NP445_16075	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NP445_16080	COG0149	triose-phosphate isomerase activity
NP445_16085	COG0126	phosphoglycerate kinase activity
NP445_16090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP445_16095	COG2390	Transcriptional regulator
NP445_16100	COG0833	amino acid
NP445_16105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NP445_16110	COG3829	transcription factor binding
NP445_16115	COG2186	Transcriptional regulator
NP445_16120	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NP445_16130	COG0534	Mate efflux family protein
NP445_16135	COG4608	Belongs to the ABC transporter superfamily
NP445_16140	COG0444	Belongs to the ABC transporter superfamily
NP445_16145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP445_16150	COG0601	transmembrane transport
NP445_16155	COG0747	negative chemotaxis
NP445_16160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP445_16165	COG0110	maltose O-acetyltransferase activity
NP445_16170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NP445_16175	COG2244	polysaccharide biosynthetic process
NP445_16180	COG5039	Polysaccharide pyruvyl transferase
NP445_16185	COG1216	Glycosyl transferase, family 2
NP445_16195	COG0438	transferase activity, transferring glycosyl groups
NP445_16200	COG1215	transferase activity, transferring glycosyl groups
NP445_16205	COG0438	transferase activity, transferring glycosyl groups
NP445_16210	COG1086	Polysaccharide biosynthesis protein
NP445_16215	COG0489	protein tyrosine kinase activity
NP445_16220	COG3944	biosynthesis protein
NP445_16225	COG1396	sequence-specific DNA binding
NP445_16235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP445_16240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP445_16245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP445_16250	COG0726	polysaccharide deacetylase
NP445_16255	COG0488	(ABC) transporter
NP445_16260	COG4608	Belongs to the ABC transporter superfamily
NP445_16275	COG0601	transmembrane transport
NP445_16280	COG0747	negative chemotaxis
NP445_16285	COG1819	glycosyl
NP445_16290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP445_16305	COG0740	serine-type endopeptidase activity
NP445_16310	COG1611	Belongs to the LOG family
NP445_16315	COG1694	Mazg nucleotide pyrophosphohydrolase
NP445_16320	COG0659	secondary active sulfate transmembrane transporter activity
NP445_16325	COG0288	reversible hydration of carbon dioxide
NP445_16330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP445_16340	COG2162	N-hydroxyarylamine O-acetyltransferase activity
NP445_16345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP445_16350	COG1481	regulation of sporulation
NP445_16355	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NP445_16360	COG1660	Displays ATPase and GTPase activities
NP445_16365	COG1051	belongs to the nudix hydrolase family
NP445_16370	COG0492	ferredoxin-NADP+ reductase activity
NP445_16380	COG0457	Tetratricopeptide repeat
NP445_16385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NP445_16385	COG0140	phosphoribosyl-ATP diphosphatase activity
NP445_16390	COG0107	imidazoleglycerol-phosphate synthase activity
NP445_16395	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NP445_16400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NP445_16405	COG0131	Imidazoleglycerol-phosphate dehydratase
NP445_16410	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NP445_16415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NP445_16420	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NP445_16425	COG4990	cell redox homeostasis
NP445_16430	COG2910	NAD(P)H-binding
NP445_16435	COG1959	2 iron, 2 sulfur cluster binding
NP445_16440	COG0110	maltose O-acetyltransferase activity
NP445_16445	COG0546	phosphoglycolate phosphatase activity
NP445_16450	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NP445_16455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NP445_16460	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NP445_16465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NP445_16470	COG0363	glucosamine-6-phosphate deaminase activity
NP445_16475	COG2188	Transcriptional regulator
NP445_16480	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NP445_16485	COG1950	PFAM Membrane protein of
NP445_16490	COG1983	PspC domain protein
NP445_16495	COG3595	metallopeptidase activity
NP445_16510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NP445_16520	COG4897	Protein conserved in bacteria
NP445_16525	COG0574	Belongs to the PEP-utilizing enzyme family
NP445_16525	COG3848	Pyruvate phosphate dikinase
NP445_16530	COG1309	transcriptional regulator
NP445_16535	COG2814	Major facilitator Superfamily
NP445_16545	COG0745	RESPONSE REGULATOR receiver
NP445_16550	COG5002	protein histidine kinase activity
NP445_16555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NP445_16560	COG0463	Glycosyl transferase, family 2
NP445_16565	COG1113	amino acid transport
NP445_16570	COG0778	Nitroreductase
NP445_16575	COG1733	regulation of RNA biosynthetic process
NP445_16580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP445_16590	COG3409	Peptidoglycan-binding domain 1 protein
NP445_16590	COG0793	Belongs to the peptidase S41A family
NP445_16595	COG0730	response to heat
NP445_16600	COG0791	NLP P60 protein
NP445_16600	COG3883	PFAM NLP P60 protein
NP445_16605	COG2177	Part of the ABC transporter FtsEX involved in
NP445_16610	COG2884	Cell division ATP-binding protein ftsE
NP445_16615	COG2010	Cytochrome c
NP445_16620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP445_16640	COG0653	protein targeting
NP445_16645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NP445_16650	COG0840	transmembrane signaling receptor activity
NP445_16665	COG1516	flagellar protein fliS
NP445_16670	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NP445_16675	COG1334	flagellar protein FlaG
NP445_16680	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NP445_16685	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
NP445_16695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP445_16700	COG1256	bacterial-type flagellum assembly
NP445_16700	COG4786	Flagellar basal body rod
NP445_16705	COG3418	PFAM FlgN family protein
NP445_16720	COG1040	competence protein
NP445_16730	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NP445_16735	COG1307	EDD domain protein, DegV family
NP445_16740	COG2197	response regulator
NP445_16745	COG4585	Histidine kinase
NP445_16750	COG1739	Uncharacterized protein family UPF0029
NP445_16755	COG1316	TRANSCRIPTIONal
NP445_16760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP445_16765	COG0438	transferase activity, transferring glycosyl groups
NP445_16770	COG1215	transferase activity, transferring glycosyl groups
NP445_16775	COG3206	protein involved in exopolysaccharide biosynthesis
NP445_16780	COG3307	-O-antigen
NP445_16785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP445_16790	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NP445_16795	COG0297	glycogen (starch) synthase activity
NP445_16795	COG0438	transferase activity, transferring glycosyl groups
NP445_16800	COG2244	polysaccharide biosynthetic process
NP445_16815	COG2247	cell wall binding repeat
NP445_16815	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP445_16820	COG2247	cell wall binding repeat
NP445_16820	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP445_16825	COG2385	sporulation resulting in formation of a cellular spore
NP445_16825	COG2247	cell wall binding repeat
NP445_16835	COG1316	TRANSCRIPTIONal
NP445_16840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NP445_16845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NP445_16850	COG1134	teichoic acid transport
NP445_16855	COG1682	transport, permease protein
NP445_16860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP445_16860	COG0463	Glycosyl transferase, family 2
NP445_16865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP445_16875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NP445_16880	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NP445_16885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP445_16890	COG4193	domain, Protein
NP445_16895	COG1482	cell wall glycoprotein biosynthetic process
NP445_16905	COG1175	transmembrane transport
NP445_16910	COG1653	transport
NP445_16915	COG2197	response regulator
NP445_16920	COG2972	Histidine kinase
NP445_16930	COG0454	-acetyltransferase
NP445_16935	COG0800	Aldolase
NP445_16940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP445_16945	COG1609	Transcriptional regulator
NP445_16950	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NP445_16955	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_16960	COG0697	spore germination
NP445_16965	COG0814	amino acid
NP445_16980	COG2814	Major facilitator Superfamily
NP445_16985	COG1316	TRANSCRIPTIONal
NP445_16990	COG0561	phosphatase activity
NP445_16995	COG0791	NLP P60 protein
NP445_17005	COG2843	Capsule synthesis protein
NP445_17015	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NP445_17020	COG0697	spore germination
NP445_17035	COG1609	Transcriptional regulator
NP445_17040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP445_17045	COG1869	D-ribose catabolic process
NP445_17050	COG1129	ABC transporter
NP445_17055	COG1172	Belongs to the binding-protein-dependent transport system permease family
NP445_17060	COG1879	ABC-type sugar transport system periplasmic component
NP445_17065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NP445_17070	COG0583	DNA-binding transcription factor activity
NP445_17075	COG0028	Belongs to the TPP enzyme family
NP445_17080	COG3527	Alpha-acetolactate decarboxylase
NP445_17085	COG1522	sequence-specific DNA binding
NP445_17090	COG2059	Chromate
NP445_17095	COG2059	Chromate
NP445_17100	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NP445_17110	COG4715	Zinc finger, swim domain protein
NP445_17115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NP445_17120	COG2202	Pas domain
NP445_17120	COG1366	Belongs to the anti-sigma-factor antagonist family
NP445_17125	COG0561	phosphatase activity
NP445_17140	COG1970	mechanosensitive ion channel activity
NP445_17145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NP445_17150	COG0457	Tetratricopeptide repeat
NP445_17155	COG4786	Flagellar basal body rod
NP445_17160	COG4786	Flagellar basal body rod
NP445_17165	COG1077	Cell shape determining protein MreB Mrl
NP445_17170	COG1609	Transcriptional regulator
NP445_17175	COG1846	Transcriptional regulator
NP445_17180	COG2814	Major facilitator Superfamily
NP445_17185	COG0671	phosphoesterase, PA-phosphatase related
NP445_17190	COG0477	Major facilitator Superfamily
NP445_17195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP445_17200	COG0765	amino acid transport
NP445_17205	COG1126	abc transporter atp-binding protein
NP445_17210	COG0004	ammonium transporteR
NP445_17215	COG0347	Belongs to the P(II) protein family
NP445_17220	COG0739	heme binding
NP445_17225	COG1247	-acetyltransferase
NP445_17260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NP445_17265	COG0523	cobalamin synthesis protein
NP445_17270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NP445_17275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NP445_17280	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NP445_17285	COG2223	nitrite transmembrane transporter activity
NP445_17295	COG2304	oxidoreductase activity
NP445_17300	COG2304	oxidoreductase activity
NP445_17305	COG2385	sporulation resulting in formation of a cellular spore
NP445_17310	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NP445_17320	COG4836	Membrane
NP445_17330	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NP445_17335	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NP445_17340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NP445_17345	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NP445_17350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NP445_17355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NP445_17360	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NP445_17365	COG0356	it plays a direct role in the translocation of protons across the membrane
NP445_17375	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NP445_17380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NP445_17385	COG4475	Protein of unknown function (DUF436)
NP445_17390	COG0698	ribose 5-phosphate isomerase
NP445_17395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP445_17400	COG1971	Probably functions as a manganese efflux pump
NP445_17405	COG0009	L-threonylcarbamoyladenylate synthase
NP445_17410	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NP445_17425	COG2890	protein-(glutamine-N5) methyltransferase activity
NP445_17430	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NP445_17435	COG0789	Transcriptional regulator
NP445_17440	COG0679	Auxin Efflux Carrier
NP445_17445	COG0281	malic enzyme
NP445_17450	COG1435	thymidine kinase activity
NP445_17455	COG0254	rRNA binding
NP445_17460	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NP445_17465	COG1494	fructose-1,6-bisphosphatase
NP445_17470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NP445_17475	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NP445_17480	COG0191	fructose-bisphosphate aldolase activity
NP445_17485	COG2204	response regulator
NP445_17490	COG4821	SIS domain
NP445_17495	COG0504	CTP synthase activity
NP445_17500	COG3343	RNA polymerase activity
NP445_17515	COG1960	acyl-CoA dehydrogenase activity
NP445_17520	COG1960	acyl-CoA dehydrogenase activity
NP445_17525	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP445_17530	COG0183	Belongs to the thiolase family
NP445_17535	COG2181	nitrate reductase activity
NP445_17535	COG0247	lactate metabolic process
NP445_17540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP445_17545	COG4294	response to UV
NP445_17555	COG1619	proteins homologs of microcin C7 resistance protein MccF
NP445_17565	COG1132	(ABC) transporter
NP445_17570	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP445_17575	COG1619	proteins homologs of microcin C7 resistance protein MccF
NP445_17580	COG0018	arginyl-trna synthetase
NP445_17585	COG4506	Protein conserved in bacteria
NP445_17595	COG0010	Belongs to the arginase family
NP445_17600	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NP445_17605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP445_17615	COG1994	Peptidase M50
NP445_17620	COG1942	4-Oxalocrotonate Tautomerase
NP445_17630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP445_17635	COG0583	DNA-binding transcription factor activity
NP445_17640	COG0431	NADPH-dependent FMN reductase
NP445_17645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP445_17650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NP445_17655	COG0454	-acetyltransferase
NP445_17660	COG0765	amino acid transport
NP445_17670	COG0765	amino acid transport
NP445_17675	COG1126	abc transporter atp-binding protein
NP445_17680	COG3465	dGTPase activity
NP445_17685	COG1078	dGTPase activity
NP445_17690	COG4844	belongs to the
NP445_17740	COG5444	nuclease activity
NP445_17770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NP445_17780	COG0280	phosphate acetyltransferase
NP445_17790	COG2814	Major facilitator Superfamily
NP445_17795	COG1522	sequence-specific DNA binding
NP445_17800	COG2814	Major facilitator Superfamily
NP445_17805	COG0077	Prephenate dehydratase
NP445_17810	COG1917	Cupin 2, conserved barrel domain protein
NP445_17815	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_17820	COG0151	Belongs to the GarS family
NP445_17825	COG0436	Aminotransferase
NP445_17830	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_17835	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NP445_17840	COG1091	dTDP-4-dehydrorhamnose reductase activity
NP445_17845	COG1088	dTDP-glucose 4,6-dehydratase activity
NP445_17850	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NP445_17855	COG3980	spore coat polysaccharide biosynthesis protein
NP445_17860	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
NP445_17865	COG2089	acid synthase
NP445_17870	COG0456	acetyltransferase
NP445_17875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP445_17880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP445_17885	COG0463	Glycosyl transferase, family 2
NP445_17905	COG2363	Small membrane protein
NP445_17910	COG2233	PERMEase
NP445_17920	COG1012	belongs to the aldehyde dehydrogenase family
NP445_17925	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NP445_17930	COG1216	Glycosyl transferase, family 2
NP445_17940	COG0351	phosphomethylpyrimidine kinase
NP445_17955	COG1621	beta-fructofuranosidase activity
NP445_17960	COG1263	PTS System
NP445_17960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP445_17965	COG3711	transcriptional antiterminator
NP445_17975	COG1404	Belongs to the peptidase S8 family
NP445_17985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP445_17990	COG0778	Nitroreductase
NP445_17995	COG0772	Belongs to the SEDS family
NP445_18005	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NP445_18010	COG1845	cytochrome c oxidase, subunit III
NP445_18015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NP445_18020	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NP445_18030	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NP445_18035	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NP445_18040	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NP445_18055	COG2246	polysaccharide biosynthetic process
NP445_18075	COG3162	membrane
NP445_18080	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP445_18100	COG0352	thiamine-phosphate diphosphorylase activity
NP445_18105	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NP445_18110	COG0583	DNA-binding transcription factor activity
NP445_18115	COG1380	Effector of murein hydrolase LrgA
NP445_18120	COG1346	cytolysis
NP445_18125	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NP445_18130	COG0346	lactoylglutathione lyase activity
NP445_18140	COG0765	amino acid transport
NP445_18145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP445_18150	COG0457	Tetratricopeptide repeat
NP445_18160	COG2357	RelA SpoT domain protein
NP445_18165	COG1172	Belongs to the binding-protein-dependent transport system permease family
NP445_18170	COG1129	ABC transporter
NP445_18180	COG3420	alginic acid biosynthetic process
NP445_18185	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP445_18195	COG1486	melibiose metabolic process
NP445_18200	COG1447	Phosphotransferase system cellobiose-specific component IIA
NP445_18205	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP445_18210	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP445_18215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP445_18215	COG3711	transcriptional antiterminator
NP445_18235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP445_18250	COG1595	DNA-templated transcription, initiation
NP445_18260	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NP445_18265	COG4988	ABC transporter
NP445_18270	COG1294	oxidase, subunit
NP445_18275	COG1271	oxidase subunit
NP445_18295	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NP445_18300	COG4509	Sortase family
NP445_18325	COG5386	Cell surface protein
NP445_18330	COG5386	Cell surface protein
NP445_18335	COG1733	regulation of RNA biosynthetic process
NP445_18340	COG2514	catechol 2,3-dioxygenase activity
NP445_18345	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP445_18345	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP445_18350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP445_18350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP445_18360	COG0726	polysaccharide deacetylase
NP445_18365	COG1447	Phosphotransferase system cellobiose-specific component IIA
NP445_18370	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP445_18375	COG2723	6-phospho-beta-galactosidase activity
NP445_18380	COG1312	Catalyzes the dehydration of D-mannonate
NP445_18385	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP445_18390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP445_18390	COG3711	transcriptional antiterminator
NP445_18415	COG1757	Na H antiporter
NP445_18420	COG1027	Aspartate ammonia-lyase
NP445_18425	COG0252	asparaginase activity
NP445_18430	COG1396	sequence-specific DNA binding
NP445_18455	COG4842	Belongs to the WXG100 family
NP445_18460	COG2195	Cleaves the N-terminal amino acid of tripeptides
NP445_18475	COG1737	Transcriptional regulator
NP445_18480	COG2084	Dehydrogenase
NP445_18490	COG2610	gluconate transmembrane transporter activity
NP445_18495	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP445_18500	COG2850	peptidyl-arginine hydroxylation
NP445_18515	COG0477	Major facilitator Superfamily
NP445_18520	COG0367	asparagine synthase
NP445_18525	COG2723	6-phospho-beta-galactosidase activity
NP445_18530	COG2190	(PTS) system
NP445_18530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP445_18530	COG1263	PTS System
NP445_18535	COG3711	transcriptional antiterminator
NP445_18540	COG3878	Protein conserved in bacteria
NP445_18550	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NP445_18555	COG1122	ATPase activity
NP445_18560	COG4721	ABC-type cobalt transport system, permease component
NP445_18565	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NP445_18600	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NP445_18605	COG0778	Nitroreductase
NP445_18610	COG1846	Transcriptional regulator
NP445_18615	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NP445_18620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP445_18625	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NP445_18630	COG2390	Transcriptional regulator
NP445_18640	COG2755	lipolytic protein G-D-S-L family
NP445_18640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NP445_18645	COG0477	Major facilitator Superfamily
NP445_18655	COG2226	methyltransferase
NP445_18665	COG0561	phosphatase activity
NP445_18670	COG0789	Transcriptional regulator
NP445_18675	COG0673	inositol 2-dehydrogenase activity
NP445_18680	COG0840	transmembrane signaling receptor activity
NP445_18685	COG1113	amino acid transport
NP445_18690	COG4335	DNA alkylation repair
NP445_18700	COG1070	Carbohydrate kinase
NP445_18705	COG1737	Transcriptional regulator
NP445_18755	COG0583	DNA-binding transcription factor activity
NP445_18760	COG1609	Transcriptional regulator
NP445_18765	COG2182	Extracellular solute-binding protein
NP445_18770	COG1175	transmembrane transport
NP445_18775	COG3833	ABC-type maltose transport systems, permease component
NP445_18785	COG1874	Beta-galactosidase
NP445_18790	COG2851	Citrate transporter
NP445_18800	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NP445_18805	COG1131	(ABC) transporter
NP445_18810	COG2824	Alkylphosphonate utilization operon protein PhnA
NP445_18815	COG1929	Belongs to the glycerate kinase type-1 family
NP445_18820	COG2610	gluconate transmembrane transporter activity
NP445_18825	COG3835	regulator
NP445_18830	COG1309	transcriptional regulator
NP445_18835	COG2814	Major facilitator Superfamily
NP445_18845	COG1136	(ABC) transporter
NP445_18850	COG0457	Tetratricopeptide repeat
NP445_18855	COG3711	transcriptional antiterminator
NP445_18860	COG2723	6-phospho-beta-galactosidase activity
NP445_18865	COG2190	(PTS) system
NP445_18865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP445_18865	COG1263	PTS System
NP445_18895	COG0494	nUDIX hydrolase
NP445_18910	COG1113	amino acid transport
NP445_18915	COG1609	Transcriptional regulator
NP445_18920	COG2814	Major facilitator Superfamily
NP445_18925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NP445_18930	COG2814	Major facilitator Superfamily
NP445_18945	COG5444	nuclease activity
NP445_18960	COG2723	6-phospho-beta-galactosidase activity
NP445_18965	COG2190	(PTS) system
NP445_18965	COG1263	PTS System
NP445_18965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP445_18970	COG2188	Transcriptional regulator
NP445_18980	COG0384	phenazine biosynthesis protein PhzF
NP445_18985	COG0583	DNA-binding transcription factor activity
NP445_19005	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP445_19020	COG3850	Histidine kinase
NP445_19020	COG5002	protein histidine kinase activity
NP445_19030	COG2409	Drug exporters of the RND superfamily
NP445_19045	COG0210	DNA helicase
NP445_19055	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NP445_19065	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NP445_19075	COG4720	Psort location CytoplasmicMembrane, score
NP445_19095	COG0456	acetyltransferase
NP445_19100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP445_19105	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NP445_19110	COG4853	Protein conserved in bacteria
NP445_19115	COG4863	YycH protein
NP445_19120	COG5002	protein histidine kinase activity
NP445_19125	COG0745	RESPONSE REGULATOR receiver
NP445_19150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NP445_19160	COG2311	Membrane
NP445_19165	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NP445_19170	COG1309	transcriptional regulator
NP445_19175	COG2124	cytochrome p450
NP445_19180	COG0346	lactoylglutathione lyase activity
NP445_19185	COG0305	Participates in initiation and elongation during chromosome replication
NP445_19205	COG2819	hydrolase of the alpha beta superfamily
NP445_19210	COG1028	Short-chain dehydrogenase reductase Sdr
NP445_19215	COG1169	isochorismate synthase
NP445_19220	COG1021	2,3-dihydroxybenzoate-AMP ligase
NP445_19225	COG3433	isochorismatase activity
NP445_19225	COG1535	isochorismatase
NP445_19230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP445_19235	COG3251	PFAM MbtH domain protein
NP445_19240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP445_19240	COG2207	Transcriptional regulator
NP445_19245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP445_19250	COG2819	hydrolase of the alpha beta superfamily
NP445_19255	COG3093	addiction module antidote protein HigA
NP445_19260	COG2807	transmembrane transport
NP445_19265	COG0359	binds to the 23S rRNA
NP445_19270	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NP445_19275	COG4241	membrane
NP445_19280	COG1227	inorganic diphosphatase activity
NP445_19290	COG1595	DNA-templated transcription, initiation
NP445_19300	COG0753	catalase activity
NP445_19305	COG0655	NAD(P)H dehydrogenase (quinone) activity
NP445_19310	COG0400	carboxylic ester hydrolase activity
NP445_19315	COG0346	lactoylglutathione lyase activity
NP445_19320	COG1174	glycine betaine transport
NP445_19325	COG1125	glycine betaine transport
NP445_19325	COG0517	IMP dehydrogenase activity
NP445_19330	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NP445_19335	COG0629	single-stranded DNA binding
NP445_19340	COG0360	Binds together with S18 to 16S ribosomal RNA
NP445_19345	COG0012	GTP binding
NP445_19350	COG4481	Protein conserved in bacteria
NP445_19365	COG3949	Membrane
NP445_19375	COG1475	DNA binding
NP445_19380	COG1192	Involved in chromosome partitioning
NP445_19390	COG1475	DNA binding
NP445_19395	COG0357	Ribosomal RNA small subunit methyltransferase G
NP445_19400	COG0445	tRNA wobble uridine modification
NP445_19405	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NP445_19410	COG1847	R3H domain protein
NP445_19415	COG0706	membrane insertase activity
NP445_19420	COG0594	ribonuclease P activity
NP445_19425	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NP445_19430	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NP445_19435	COG0592	DNA-directed DNA polymerase activity
NP445_19440	COG2501	S4 domain
NP445_19445	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NP445_19455	COG0187	DNA topoisomerase II activity