locus-tag class description EVS87_000015 ENOG4108Z0C Uvrb UvrC protein EVS87_000020 ENOG41066A3 ATP guanido phosphotransferase EVS87_000030 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EVS87_000035 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) EVS87_000040 ENOG4105CTP PilT protein domain protein EVS87_000045 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) EVS87_000050 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) EVS87_000055 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) EVS87_000060 ENOG4105D7W serine acetyltransferase EVS87_000065 ENOG4105C8N cysteinyl-tRNA synthetase EVS87_000070 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) EVS87_000075 ENOG4105C2N RNA methyltransferase TrmH family group 3 EVS87_000080 ENOG4105M0M Tetracycline resistance protein EVS87_000100 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EVS87_000105 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) EVS87_000110 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) EVS87_000115 ENOG4108VZM 50s ribosomal protein L10 EVS87_000120 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) EVS87_000125 ENOG4107Y49 methyltransferase EVS87_000130 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EVS87_000135 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EVS87_000140 ENOG4105XPM ribosomal protein EVS87_000145 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) EVS87_000150 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) EVS87_000155 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) EVS87_000165 ENOG4107SKW Inherit from COG: Alpha beta hydrolase EVS87_000170 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) EVS87_000175 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) EVS87_000180 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EVS87_000185 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EVS87_000190 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity EVS87_000195 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EVS87_000200 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EVS87_000205 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EVS87_000210 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EVS87_000215 ENOG41082SA 50s ribosomal protein l29 EVS87_000220 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EVS87_000225 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) EVS87_000230 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EVS87_000235 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits EVS87_000240 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EVS87_000245 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EVS87_000250 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) EVS87_000255 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EVS87_000260 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EVS87_000265 ENOG4105VPB 50S ribosomal protein L30 EVS87_000270 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) EVS87_000275 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EVS87_000280 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) EVS87_000285 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EVS87_000295 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) EVS87_000305 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EVS87_000310 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) EVS87_000315 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EVS87_000320 ENOG4108ZT0 50S ribosomal protein l17 EVS87_000325 ENOG4108JJB ABC transporter EVS87_000330 ENOG4108JJB ABC transporter EVS87_000335 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) EVS87_000340 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) EVS87_000345 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) EVS87_000350 ENOG4108UJD 30S ribosomal protein S9 EVS87_000390 ENOG4105D1F ATP-binding protein EVS87_000405 ENOG4108NMV polysaccharide deacetylase EVS87_000435 ENOG4105CHH sulfate transporter EVS87_000445 ENOG4105EHZ conserved protein UCP016719 EVS87_000450 ENOG4105D17 glycoside hydrolase, family 3 domain protein EVS87_000470 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate EVS87_000505 ENOG4105EMN RNA polymerase sigma factor EVS87_000515 ENOG4105C8B TIGR00159 family EVS87_000520 ENOG4107U5W ybbr family EVS87_000525 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) EVS87_000530 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EVS87_000550 ENOG4105DA5 (ABC) transporter EVS87_000560 ENOG4107R39 (ABC) transporter EVS87_000565 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EVS87_000570 ENOG4105U3E Transcriptional regulator EVS87_000580 ENOG4108WUZ (ABC) transporter EVS87_000630 ENOG4105VZ8 Transcriptional regulator EVS87_000640 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EVS87_000650 ENOG4105YA8 Transcriptional regulator EVS87_000670 ENOG4107VXM glycerophosphoryl diester phosphodiesterase EVS87_000675 ENOG4105CXY transporter EVS87_000685 ENOG4105C7Z Conserved Protein EVS87_000700 ENOG4105WAB arsR family transcriptional regulator EVS87_000715 ENOG4105XTG Pfam:DUF156 EVS87_000720 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase EVS87_000730 ENOG4105VFE sira family EVS87_000735 ENOG4107TPS domain protein EVS87_000740 ENOG4105VFE sira family EVS87_000745 ENOG41087NI Sulfite exporter TauE/SafE EVS87_000750 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) EVS87_000755 ENOG4108SUT Major Facilitator Superfamily EVS87_000780 ENOG4105EWC Purine nucleoside phosphorylase EVS87_000795 ENOG4107SCQ Iron-containing alcohol dehydrogenase EVS87_000800 ENOG4105C72 UPF0176 protein EVS87_000805 ENOG4107QTZ amino acid EVS87_000815 ENOG4105CID antiterminator EVS87_000820 ENOG4105C5Y PTS System EVS87_000825 ENOG4105CS2 ec 3.2.1.21 EVS87_000845 ENOG4108JJ8 (ABC) transporter EVS87_000850 ENOG4108JJ9 ABC, transporter EVS87_000860 ENOG4105EMD TRANSCRIPTIONal EVS87_000865 ENOG4105EVU fructokinase EVS87_000870 ENOG4105C8I hydrolase, family 38 EVS87_000875 ENOG4105DM4 PTS System EVS87_000880 ENOG4108YRF PTS System EVS87_000885 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein EVS87_000890 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EVS87_000905 ENOG4108IQI permease EVS87_000910 ENOG4108J5H Homocysteine s-methyltransferase EVS87_000915 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) EVS87_000935 ENOG4105C2C drug resistance transporter, Bcr CflA EVS87_000955 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin EVS87_000965 ENOG4105J7D transcriptional regulator EVS87_000980 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EVS87_000985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EVS87_000990 ENOG4108JQ5 ABC transporter EVS87_000995 ENOG4105C59 p-type ATPase EVS87_001005 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EVS87_001010 ENOG4108U1V ABC transporter, permease EVS87_001015 ENOG4105E0A ABC, transporter EVS87_001020 ENOG41067TZ transcriptional regulator, MarR family EVS87_001030 ENOG4105CUB amino acid EVS87_001040 ENOG4105D74 hydrolase EVS87_001050 ENOG4105CSV Glutaminase EVS87_001065 ENOG41060AI SEC-C motif EVS87_001075 ENOG4107SET aldo keto reductase EVS87_001085 ENOG4107Y7X LytTR EVS87_001090 ENOG4108IUW ABC transporter EVS87_001095 ENOG4108SDH ABC, transporter EVS87_001120 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EVS87_001130 ENOG4105DEN Luciferase family EVS87_001135 ENOG4108N0M stress protein EVS87_001140 ENOG4106FN3 tellurium resistance protein EVS87_001145 ENOG4106FN3 tellurium resistance protein EVS87_001150 ENOG4107TS3 membrane protein, TerC EVS87_001175 ENOG4108TTB tellurium resistance protein EVS87_001185 ENOG4108IJ7 Glycine betaine EVS87_001190 ENOG4107SQ8 Glycine betaine EVS87_001220 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EVS87_001240 ENOG4105TRI Hydrolase EVS87_001280 ENOG4105EIG urea carboxylase-associated protein 1 EVS87_001285 ENOG4107RMH nh(3)-dependent nad( ) synthetase EVS87_001300 ENOG4105FF2 Type I DHQase EVS87_001305 ENOG4105C7K acetolactate synthase EVS87_001315 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EVS87_001320 ENOG4105DJB Major Facilitator Superfamily EVS87_001330 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region EVS87_001335 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) EVS87_001340 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EVS87_001350 ENOG41079KZ Major Facilitator Superfamily EVS87_001355 ENOG41089UC methyltransferase, type 11 EVS87_001360 ENOG4105C5Q Transcriptional regulator EVS87_001370 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EVS87_001375 ENOG4105I82 acetyl xylan esterase EVS87_001385 ENOG410756H nucleotidyltransferase EVS87_001395 ENOG4105C26 Dehydrogenase EVS87_001400 ENOG4107YHD transcriptional regulator EVS87_001405 ENOG4107R5R arsenical pump membrane protein EVS87_001410 ENOG4105E5Q amino acid AbC transporter EVS87_001415 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein EVS87_001425 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein EVS87_001435 ENOG4108AQF aminoglycoside N(3)-acetyltransferase EVS87_001445 ENOG4105C8Q Methyl-accepting chemotaxis EVS87_001475 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EVS87_001480 ENOG4105F38 ABC transporter, permease EVS87_001490 ENOG4105CEY Amp-dependent synthetase and ligase EVS87_001520 ENOG4105SX7 Transporter EVS87_001535 ENOG41086D8 Transcriptional regulator EVS87_001550 ENOG4105CGH 5'-nucleotidase EVS87_001560 ENOG4108M14 stage v sporulation protein t EVS87_001565 ENOG4105CDA abc transporter atp-binding protein EVS87_001570 ENOG4105DRP amino acid AbC transporter EVS87_001585 ENOG4108IQI permease EVS87_001590 ENOG4105DUX Transporter EVS87_001600 ENOG4105CPU Monooxygenase EVS87_001605 ENOG4108XSB acetyltransferase, (GNAT) family EVS87_001610 ENOG4105EAB amino acid AbC transporter EVS87_001615 ENOG4108HW4 amino acid AbC transporter EVS87_001625 ENOG4105CH2 amidohydrolase EVS87_001630 ENOG4108PGP mmge prpd family protein EVS87_001640 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EVS87_001645 ENOG4105BZU Histidine kinase EVS87_001660 ENOG4105CFH Aspartokinase EVS87_001670 ENOG4105R8C Transcriptional regulator EVS87_001680 ENOG4105YVS arsR family transcriptional regulator EVS87_001690 ENOG4108JPW Aminotransferase EVS87_001695 ENOG4107QTZ amino acid EVS87_001700 ENOG4105C26 Dehydrogenase EVS87_001705 ENOG4105DYS nad(p)h dehydrogenase (quinone) EVS87_001710 ENOG4105KTB nuclear export factor GLE1 EVS87_001715 ENOG4108T5E Copper resistance protein EVS87_001730 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase EVS87_001735 ENOG4105C8Q Methyl-accepting chemotaxis EVS87_001775 ENOG4105X3H Excalibur domain protein EVS87_001785 ENOG4105E7W lamb ycsf family protein EVS87_001790 ENOG4105C5A transporter EVS87_001795 ENOG4105CFM UPF0317 protein EVS87_001800 ENOG4105P4J Allophanate hydrolase, subunit 1 EVS87_001810 ENOG4107258 Transcriptional regulator EVS87_001815 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EVS87_001820 ENOG4105XJB lipolytic protein G-D-S-L family EVS87_001830 ENOG4105ETD TRANSCRIPTIONal EVS87_001835 ENOG4105HMZ Methyltransferase EVS87_001840 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EVS87_001845 ENOG410606W general stress protein EVS87_001865 ENOG4105VCH membrane EVS87_001870 ENOG4105C9U ATP-dependent DNA helicase RecQ EVS87_001885 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) EVS87_001890 ENOG4107R8N Glycosyl transferase, family 2 EVS87_001900 ENOG4105C0X amino acid EVS87_001960 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) EVS87_001965 ENOG4107BMA Transglycosylase associated protein EVS87_001970 ENOG4105EU9 EVS87_001975 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EVS87_001980 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EVS87_001985 ENOG4108MRH transcriptional regulatory protein EVS87_001990 ENOG4107QJT sodium dicarboxylate symporter EVS87_001995 ENOG4106F5Q Membrane EVS87_002005 ENOG4105CJ1 ABC, transporter EVS87_002025 ENOG4105SZ6 Thioredoxin EVS87_002030 ENOG4105CPF Cell wall formation (By similarity) EVS87_002035 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) EVS87_002050 ENOG4105C1J atp-dependent rna helicase EVS87_002055 ENOG410905X membrane-flanked domain protein EVS87_002060 ENOG4105CKV Membrane EVS87_002075 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein EVS87_002080 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EVS87_002090 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) EVS87_002095 ENOG4107MMM Anti-sigma-factor antagonist EVS87_002100 ENOG4105FUA antagonist EVS87_002105 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase EVS87_002110 ENOG4107SGM protein serine threonine phosphatase EVS87_002115 ENOG4105WN5 stage II sporulation protein EVS87_002120 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EVS87_002130 ENOG41064BQ Phosphatase EVS87_002150 ENOG4107RUY (E1 component), alpha subunit EVS87_002160 ENOG4107QKR Dehydrogenase EVS87_002170 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EVS87_002225 ENOG4105VEQ Cold shock protein EVS87_002230 ENOG4108VJ1 Transcriptional regulator (CarD family EVS87_002235 ENOG4105DQ4 alcohol dehydrogenase EVS87_002240 ENOG4105VUF Transcriptional regulator EVS87_002255 ENOG4105C0R drug resistance transporter emrb qaca subfamily EVS87_002270 ENOG4107GJV short-chain dehydrogenase reductase EVS87_002280 ENOG4107RB3 L-asparaginase EVS87_002310 ENOG4105H93 Acyltransferase family EVS87_002315 ENOG4105EYF MMPL domain protein EVS87_002320 ENOG4105ENE Histidine kinase EVS87_002325 ENOG4108VB1 regulatoR EVS87_002355 ENOG4105VDT -acetyltransferase EVS87_002360 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase EVS87_002370 ENOG4105ST3 Transcriptional regulator EVS87_002375 ENOG4105NAE bifunctional deaminase-reductase domain protein EVS87_002380 ENOG41090MY MarR family Transcriptional regulator EVS87_002385 ENOG4108TVJ Nitroreductase EVS87_002400 ENOG4108JCI Transcriptional regulator EVS87_002405 ENOG4108VP3 Lysine exporter protein (LysE YggA) EVS87_002410 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) EVS87_002430 ENOG4108UMN azlc family EVS87_002485 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) EVS87_002490 ENOG4105K8N protein family UPF0079, ATPase EVS87_002495 ENOG41072GX Peptidase M22 Glycoprotease EVS87_002500 ENOG410801F ribosomal-protein-alanine acetyltransferase EVS87_002505 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EVS87_002510 ENOG4105C5H ABC transporter EVS87_002515 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) EVS87_002520 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) EVS87_002525 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EVS87_002530 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EVS87_002545 ENOG4108TYN CAAX amino terminal protease family protein EVS87_002550 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) EVS87_002555 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) EVS87_002575 ENOG41067QW Transcriptional regulator EVS87_002590 ENOG4108ZUE Phage regulatory protein rha EVS87_002610 ENOG4108NF7 phage-type endonuclease EVS87_002615 ENOG4108PNI recT protein EVS87_002845 ENOG4108U05 Transcriptional regulator EVS87_002850 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 EVS87_002860 ENOG4108VXD carboxy-peptidase EVS87_002900 ENOG4107STQ Multicopper oxidase EVS87_002905 ENOG4105C85 amino acid EVS87_002915 ENOG4105C7R Atpase associated with various cellular activities aaa_3 EVS87_002930 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) EVS87_002950 ENOG4105DY9 regulatoR EVS87_002955 ENOG4105KNA -acetyltransferase EVS87_002965 ENOG4105JVQ RNA Polymerase EVS87_002975 ENOG4108RWP Major Facilitator Superfamily protein EVS87_002980 ENOG4105GZI Transcriptional regulator EVS87_002985 ENOG4105C7N Xanthine uracil vitamin C permease EVS87_003005 ENOG4108U5N UPF0316 protein EVS87_003015 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EVS87_003020 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EVS87_003025 ENOG4105C83 adenylosuccinate lyase EVS87_003030 ENOG4105C8V SAICAR synthetase EVS87_003035 ENOG4105VR9 phosphoribosylformylglycinamidine synthase EVS87_003045 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii EVS87_003055 ENOG4105CXB phosphoribosylaminoimidazole synthetase EVS87_003060 ENOG4108V3E phosphoribosylglycinamide formyltransferase EVS87_003065 ENOG4105DC1 bifunctional purine biosynthesis protein purh EVS87_003070 ENOG4105C12 Phosphoribosylglycinamide synthetase EVS87_003090 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EVS87_003105 ENOG4107S4Y M20 DapE family protein YgeY EVS87_003120 ENOG4105KGF protein, YerC YecD EVS87_003130 ENOG4105CBC glutamate synthase EVS87_003145 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) EVS87_003150 ENOG4105C4R Atp-dependent dna helicase EVS87_003155 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EVS87_003170 ENOG4105CRN Aminoglycoside phosphotransferase EVS87_003175 ENOG4105KT7 mgtC SapB transporter EVS87_003180 ENOG4105CK7 Sodium proline symporter EVS87_003185 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EVS87_003190 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) EVS87_003195 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) EVS87_003200 ENOG4108IG5 Transcriptional regulator EVS87_003215 ENOG4105DU0 nucleoside hydrolase EVS87_003220 ENOG4105CBD Diacylglycerol kinase EVS87_003225 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EVS87_003235 ENOG4107EV6 Inherit from COG: YD repeat protein EVS87_003255 ENOG41062ES Transcriptional regulator EVS87_003260 ENOG4105C3M thioredoxin reductase EVS87_003275 ENOG4105F8D glycoside hydrolase family 4 EVS87_003280 ENOG4105HX0 Transcriptional regulator EVS87_003305 ENOG4108R1P EVS87_003325 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase EVS87_003335 ENOG41090R9 glycosyltransferase EVS87_003340 ENOG4107R51 Glycosyl transferase, family 2 EVS87_003345 ENOG41090R9 glycosyltransferase EVS87_003350 ENOG4105EU0 Major facilitator Superfamily EVS87_003355 ENOG4107RVG penicillin-binding protein EVS87_003360 ENOG4105C8P )-transporter EVS87_003390 ENOG4105CUB amino acid EVS87_003395 ENOG4107TVC Glycosyl transferase, family 2 EVS87_003400 ENOG4105C5H ABC transporter EVS87_003405 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) EVS87_003410 ENOG4107SWG transcriptional regulator MERR family EVS87_003415 ENOG4105DXB Major Facilitator superfamily EVS87_003420 ENOG4105C5H ABC transporter EVS87_003425 ENOG4105FDU atp-dependent rna helicase EVS87_003430 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EVS87_003450 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EVS87_003455 ENOG4105E6M Sulphatase-modifying factor protein EVS87_003465 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EVS87_003480 ENOG4108MRH transcriptional regulatory protein EVS87_003500 ENOG4105PY6 Phenolic acid decarboxylase EVS87_003505 ENOG4105U3E Transcriptional regulator EVS87_003520 ENOG41084AG Acylphosphatase EVS87_003525 ENOG4108RPX mosc domain containing protein EVS87_003535 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) EVS87_003545 ENOG4105NX3 Membrane EVS87_003565 ENOG4105DY8 decarboxylase EVS87_003570 ENOG4105C8Q Methyl-accepting chemotaxis EVS87_003580 ENOG4105C5Y PTS System EVS87_003585 ENOG4105CG3 alpha amylase, catalytic region EVS87_003590 ENOG4107414 GntR family transcriptional regulator EVS87_003600 ENOG4105CGH 5'-nucleotidase EVS87_003605 ENOG4107RKG DJ-1/PfpI family EVS87_003615 ENOG4105BZG amino acid carrier protein EVS87_003625 ENOG4105KJF protein tyrosine phosphatase EVS87_003635 ENOG4107U9T Pfam:Ribonuclease_BN EVS87_003640 ENOG4108ISG Major Facilitator EVS87_003650 ENOG4105UPD Calcium Proton EVS87_003665 ENOG4108IUX (ABC) transporter EVS87_003690 ENOG4105CDY transcriptional regulatory protein EVS87_003700 ENOG4105D8X mechanosensitive ion channel EVS87_003725 ENOG4105D7N magnesium and cobalt transport protein CorA EVS87_003740 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EVS87_003755 ENOG4107TXC Transcriptional regulator EVS87_003760 ENOG4108RWP Major Facilitator Superfamily protein EVS87_003815 ENOG410839T multidrug resistance protein EVS87_003835 ENOG4107TDE lipolytic protein G-D-S-L family EVS87_003850 ENOG4108HUF Transporter EVS87_003855 ENOG4105BZ1 (ABC) transporter EVS87_003860 ENOG4105KK4 UPF0060 membrane protein EVS87_003865 ENOG4105K6V RNA polymerase EVS87_003885 ENOG4108YYS metal-dependent hydrolase (By similarity) EVS87_003895 ENOG410834F Transcriptional regulator EVS87_003920 ENOG4107Y03 Nitroreductase EVS87_003935 ENOG4105ECP epimerase EVS87_003940 ENOG4105KC9 Modulates RecA activity (By similarity) EVS87_003965 ENOG4105CKK Glycosyl transferase, family 2 EVS87_003970 ENOG4105EJV Membrane EVS87_003975 ENOG4105MSY salicylate hydroxylase EVS87_003990 ENOG4105F0F Oxalate decarboxylase EVS87_004000 ENOG4106DF4 Sigma-70, region 4 EVS87_004045 ENOG41067AE Membrane-bound metal-dependent hydrolase EVS87_004050 ENOG4105CEN a g-specific adenine glycosylase EVS87_004055 ENOG4106BXE EVS87_004060 ENOG4105CAN Short-chain dehydrogenase reductase Sdr EVS87_004075 ENOG4105EVI UPF0374 protein EVS87_004080 ENOG4105BZ1 (ABC) transporter EVS87_004085 ENOG4105C3U ABC transporter EVS87_004090 ENOG4108JQ7 (ABC) transporter EVS87_004095 ENOG4105DEF Extracellular solute-binding protein, family 5 EVS87_004100 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EVS87_004105 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EVS87_004110 ENOG4107NBY Membrane EVS87_004115 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EVS87_004120 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EVS87_004125 ENOG4105G5W regulator Fur family EVS87_004275 ENOG4105E0M Sulfatase EVS87_004295 ENOG4105E2Y ABC, transporter EVS87_004300 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein EVS87_004305 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EVS87_004320 ENOG4105CJ1 ABC, transporter EVS87_004355 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EVS87_004365 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EVS87_004370 ENOG4105CYN Serine protein kinase EVS87_004375 ENOG4106AKX UPF0229 protein EVS87_004380 ENOG4105CW7 secretion protein, HlyD family EVS87_004385 ENOG4105C0R drug resistance transporter emrb qaca subfamily EVS87_004390 ENOG4105CS1 NAD(P)H quinone oxidoreductase EVS87_004400 ENOG4105VEQ Cold shock protein EVS87_004410 ENOG4105BZU Histidine kinase EVS87_004440 ENOG4105BZU Histidine kinase EVS87_004455 ENOG4108YBP pseudouridine synthase EVS87_004465 ENOG4107YBY Hydrolase EVS87_004470 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EVS87_004490 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR EVS87_004495 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EVS87_004500 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator EVS87_004510 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) EVS87_004515 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EVS87_004525 ENOG4105BZU Histidine kinase EVS87_004530 ENOG4105WH1 Two component transcriptional regulator luxr family EVS87_004545 ENOG4105CH6 catalase EVS87_004550 ENOG4105KPV Transcriptional regulator EVS87_004555 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EVS87_004560 ENOG4105ED1 spovr family EVS87_004565 ENOG4105G6Z alkaline phosphatase EVS87_004575 ENOG4105CUB amino acid EVS87_004585 ENOG4105J37 EVS87_004590 ENOG4108AEY RNA polymerase sigma factor EVS87_004595 ENOG4105F6E Acyl-transferase EVS87_004600 ENOG4105C37 (CBS) domain EVS87_004610 ENOG4105C37 (CBS) domain EVS87_004620 ENOG4106A8V Protein CrcB homolog EVS87_004625 ENOG4105WMR Protein CrcB homolog EVS87_004630 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EVS87_004640 ENOG4105D64 Mechanosensitive ion channel EVS87_004645 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EVS87_004650 ENOG4107VMI polysaccharide deacetylase EVS87_004655 ENOG4105F0I Aminotransferase EVS87_004665 ENOG4105BZ1 (ABC) transporter EVS87_004670 ENOG4105BZ1 (ABC) transporter EVS87_004705 ENOG410839P EVS87_004715 ENOG4108UH6 UPF0754 membrane protein EVS87_004720 ENOG4105WZB UPF0342 protein EVS87_004730 ENOG4105D4P Coproporphyrinogen iii oxidase EVS87_004740 ENOG4107S91 Sodium hydrogen exchanger EVS87_004745 ENOG4105NCW Trka-c domain protein EVS87_004755 ENOG4105CGU Enoyl-CoA hydratase EVS87_004765 ENOG4107VRP DNA repair exonuclease EVS87_004770 ENOG4106D4I domain protein EVS87_004785 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) EVS87_004830 ENOG4105NBU tryptophan transport protein EVS87_004835 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) EVS87_004840 ENOG4105K59 histidine triad (HIT) protein EVS87_004870 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation EVS87_004875 ENOG4105BZ4 penicillin-binding protein EVS87_004880 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) EVS87_004885 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) EVS87_004890 ENOG4105C1Q protoporphyrinogen oxidase EVS87_004900 ENOG4105ECB domain protein EVS87_004905 ENOG4105DER m42 family EVS87_004915 ENOG4106AXD EVS87_004920 ENOG4108RQ5 Beta-lactamase domain-containing protein EVS87_004925 ENOG4105DF9 Lipoate-protein, ligase EVS87_004930 ENOG4105CEY Amp-dependent synthetase and ligase EVS87_004940 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 EVS87_004945 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EVS87_004950 ENOG4107TB6 phosphoglycerate mutase EVS87_004955 ENOG4106YBV Methyl-accepting chemotaxis EVS87_004975 ENOG4105XVF Competence transcription factor EVS87_004980 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EVS87_004985 ENOG410635T phage-like element pbsx protein EVS87_005010 ENOG4108ZUE Phage regulatory protein rha EVS87_005030 ENOG4108NF7 phage-type endonuclease EVS87_005035 ENOG4108PNI recT protein EVS87_005055 ENOG4105QBX endodeoxyribonuclease RusA EVS87_005170 ENOG4108FKH Transglycosylase SLT domain EVS87_005210 ENOG41068G1 EVS87_005290 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EVS87_005295 ENOG4105C0R drug resistance transporter emrb qaca subfamily EVS87_005300 ENOG41067XF inhibitor EVS87_005305 ENOG4105DHS permease protein EVS87_005310 ENOG4105CM4 permease protein EVS87_005315 ENOG4108IPW abc transporter atp-binding protein EVS87_005325 ENOG4108KGH TRANSCRIPTIONal EVS87_005355 ENOG4108KK1 membrane protein AbrB duplication EVS87_005385 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation EVS87_005395 ENOG4105EYH Exonuclease EVS87_005455 ENOG4105ERH Fumarylacetoacetate hydrolase EVS87_005460 ENOG4106BKT UPF0344 protein EVS87_005470 ENOG4105CAQ asparagine synthetase EVS87_005490 ENOG4105UQX Mate efflux family protein EVS87_005495 ENOG4106HBX Transcriptional Regulator AraC Family EVS87_005520 ENOG4105DY8 decarboxylase EVS87_005565 ENOG4108VPT UPF0234 protein EVS87_005570 ENOG4105QNR S1 RNA binding domain protein EVS87_005575 ENOG4105DIH basic membrane EVS87_005580 ENOG4105C8Q Methyl-accepting chemotaxis EVS87_005585 ENOG4105EPR degv family EVS87_005590 ENOG4107AYK membrAne EVS87_005600 ENOG41073B9 EVS87_005610 ENOG4108KP7 hydrolase EVS87_005615 ENOG4108MXZ Esterase EVS87_005620 ENOG4105VG1 fes assembly suf system protein EVS87_005625 ENOG4105IQ5 FAD linked oxidase domain protein EVS87_005635 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EVS87_005645 ENOG4105CAS nag kinase EVS87_005650 ENOG4105C8Y Acetylornithine aminotransferase EVS87_005655 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EVS87_005665 ENOG4105DBV ornithine carbamoyltransferase EVS87_005695 ENOG4107RMD Basic membrane lipoprotein EVS87_005710 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) EVS87_005715 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EVS87_005725 ENOG4105C3U ABC transporter EVS87_005730 ENOG4108JQ7 (ABC) transporter EVS87_005745 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EVS87_005755 ENOG4105C31 Tryptophanyl-tRNA synthetase EVS87_005770 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EVS87_005775 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EVS87_005785 ENOG4108JQ7 (ABC) transporter EVS87_005800 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) EVS87_005805 ENOG4108ZCF integral membrane protein EVS87_005810 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis EVS87_005815 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EVS87_005825 ENOG4105DPN Oligoendopeptidase f EVS87_005835 ENOG4105T58 Dithiol-disulfide isomerase EVS87_005840 ENOG4108Z18 K06886 hemoglobin EVS87_005845 ENOG4105E4C Lytic transglycosylase catalytic EVS87_005850 ENOG4105MIX Adenylate cyclase EVS87_005855 ENOG4106EFP UPF0738 protein EVS87_005865 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EVS87_005870 ENOG4105EMS pseudouridine synthase EVS87_005875 ENOG4107S1Q Phosphatase EVS87_005885 ENOG4105ETU transcriptional activator (TenA EVS87_005890 ENOG4108VEU Thiamine monophosphate synthase EVS87_005905 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) EVS87_005910 ENOG4105D06 uba thif-type nad fad binding protein EVS87_005915 ENOG4105DWF phosphomethylpyrimidine kinase EVS87_005920 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EVS87_005925 ENOG4107A88 EVS87_005975 ENOG4105ENA helicase EVS87_006000 ENOG4105C28 cystathionine EVS87_006005 ENOG4105C28 cystathionine EVS87_006015 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) EVS87_006035 ENOG4105DJ2 Major Facilitator Superfamily EVS87_006045 ENOG4107RSM transcriptional regulator EVS87_006085 ENOG4105DUM transcriptional regulator, lysR family EVS87_006105 ENOG4107V2S Transcriptional regulator EVS87_006110 ENOG4105DJ2 Major Facilitator Superfamily EVS87_006130 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EVS87_006140 ENOG4105PF9 Transcriptional regulator EVS87_006150 ENOG4105I03 Flagellin EVS87_006155 ENOG4105I03 Flagellin EVS87_006175 ENOG4105K7W phage-related replication protein EVS87_006180 ENOG410635T phage-like element pbsx protein EVS87_006185 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EVS87_006200 ENOG4105CJ3 phosphate transporter EVS87_006205 ENOG4107GRR phosphate transport regulator EVS87_006215 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EVS87_006220 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EVS87_006225 ENOG4108I5D sulfate abc transporter EVS87_006230 ENOG4105ECW sulfate abc transporter EVS87_006235 ENOG4108IJ6 ABC transporter EVS87_006245 ENOG4105DT3 PTS system, galactitol-specific IIc component EVS87_006265 ENOG4107RUY (E1 component), alpha subunit EVS87_006270 ENOG4105CPP Dehydrogenase, E1 component EVS87_006275 ENOG4107QKR Dehydrogenase EVS87_006285 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EVS87_006290 ENOG4105CHR reductase EVS87_006295 ENOG4107RHR regulatoR EVS87_006305 ENOG4107R7I amino acid EVS87_006315 ENOG4105C0H protease EVS87_006325 ENOG4108ME1 Peptidase M55 D-aminopeptidase EVS87_006330 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EVS87_006335 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EVS87_006340 ENOG4105C3U ABC transporter EVS87_006350 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EVS87_006355 ENOG4105DTQ mandelate racemase muconate lactonizing EVS87_006360 ENOG4107SN7 NLP P60 protein EVS87_006365 ENOG4108JQ7 (ABC) transporter EVS87_006370 ENOG4107TUM Amidinotransferase EVS87_006375 ENOG4108S4H thioesterase Superfamily protein EVS87_006380 ENOG4105K7K Transcriptional regulator EVS87_006395 ENOG4108428 Inherit from COG: -acetyltransferase EVS87_006400 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EVS87_006405 ENOG410839T multidrug resistance protein EVS87_006410 ENOG41080TC multidrug resistance protein EVS87_006420 ENOG4105CIY formyltetrahydrofolate deformylase EVS87_006425 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EVS87_006430 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EVS87_006450 ENOG4105K56 Transcriptional regulator EVS87_006455 ENOG4108ZHJ Organic hydroperoxide resistance protein EVS87_006460 ENOG4107Y2X deaminase EVS87_006465 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EVS87_006470 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EVS87_006485 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EVS87_006490 ENOG41062D9 Histidine kinase EVS87_006500 ENOG4106849 propeptide, pepSY amd peptidase M4 EVS87_006510 ENOG4105CJW magnesium transporter EVS87_006530 ENOG4105V75 Transcriptional regulator EVS87_006545 ENOG4105BZU Histidine kinase EVS87_006550 ENOG4107T5V SNARE associated Golgi EVS87_006555 ENOG4107TS3 membrane protein, TerC EVS87_006560 ENOG4108WZW RNA polymerase sigma EVS87_006570 ENOG410681C small acid-soluble spore protein EVS87_006580 ENOG4105D0M Protease HtpX homolog EVS87_006590 ENOG410900G Protein of unknown function (DUF421) EVS87_006600 ENOG4108TGC Acyltransferase EVS87_006605 ENOG4105BZU Histidine kinase EVS87_006610 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EVS87_006615 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) EVS87_006620 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) EVS87_006630 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate EVS87_006635 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) EVS87_006640 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) EVS87_006645 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) EVS87_006655 ENOG4105BZU Histidine kinase EVS87_006660 ENOG41090MY MarR family Transcriptional regulator EVS87_006665 ENOG4105ER2 Ompa motb domain protein EVS87_006670 ENOG4105E14 MotA TolQ exbB proton channel EVS87_006685 ENOG4108K88 Membrane EVS87_006690 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) EVS87_006695 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase EVS87_006700 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EVS87_006705 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) EVS87_006725 ENOG4105F0V Cell wall hydrolase EVS87_006740 ENOG4105C59 p-type ATPase EVS87_006745 ENOG4105DC7 peptidase M24 EVS87_006755 ENOG4105CID antiterminator EVS87_006765 ENOG4105KRI phosphocarrier protein (HPr EVS87_006770 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EVS87_006780 ENOG4105F6S Spore photoproduct lyase EVS87_006785 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer EVS87_006790 ENOG4105CHR reductase EVS87_006795 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EVS87_006800 ENOG4105K4I Scp-like extracellular EVS87_006810 ENOG4105BZU Histidine kinase EVS87_006815 ENOG4105CHM Aminotransferase EVS87_006825 ENOG41085PJ rdd domain containing protein EVS87_006835 ENOG4107R88 Chemotaxis protein (CheV) EVS87_006840 ENOG4105UIN EVS87_006855 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein EVS87_006865 ENOG4105K6S Short-chain dehydrogenase reductase Sdr EVS87_006870 ENOG4105EPM Diguanylate phosphodiesterase EVS87_006875 ENOG4105WEF catalase EVS87_006880 ENOG4107IN1 Protein of unknown function (DUF1797) EVS87_006885 ENOG4108XRC Protein of unknown function (DUF458) EVS87_006920 ENOG4105NQC Flavodoxin EVS87_006925 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) EVS87_006935 ENOG4106AUC UPF0180 protein EVS87_006940 ENOG4105D8X mechanosensitive ion channel EVS87_006945 ENOG4105D3R alkyl hydroperoxide reductase EVS87_006950 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EVS87_006965 ENOG41080QG Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) EVS87_006970 ENOG4105D06 uba thif-type nad fad binding protein EVS87_006975 ENOG4105CVM Molybdenum cofactor synthesis domain protein EVS87_006980 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein EVS87_006985 ENOG4108ZAF Molybdopterin EVS87_006990 ENOG41067WU Molybdopterin converting factor (Subunit 1) EVS87_007005 ENOG4107X8C Efflux transporter RND family MFP subunit EVS87_007010 ENOG4105C19 ABC transporter EVS87_007015 ENOG4107RBB ABC transporter, permease EVS87_007020 ENOG4105E98 transcriptional regulator DeoR family EVS87_007025 ENOG4105DE4 1-phosphofructokinase EVS87_007030 ENOG4105DM4 PTS System EVS87_007045 ENOG4105C5H ABC transporter EVS87_007065 ENOG4105BZU Histidine kinase EVS87_007075 ENOG4107ZYR domain protein EVS87_007080 ENOG4105CPN adenine deaminase EVS87_007085 ENOG4105CN5 Metallo-Beta-Lactamase EVS87_007095 ENOG4108X4Q Hydrolase EVS87_007100 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EVS87_007120 ENOG4105CPP Dehydrogenase, E1 component EVS87_007125 ENOG4105C7S Dehydrogenase EVS87_007130 ENOG4107QN2 dihydrolipoyl dehydrogenase EVS87_007150 ENOG4105CXN decarboxylase EVS87_007160 ENOG4108WQ8 UPF0637 protein EVS87_007170 ENOG4105ECY inositol monophosphatase EVS87_007205 ENOG4105CI3 gtp-binding protein typa EVS87_007210 ENOG4105QA2 EVS87_007225 ENOG4108IAB Phoh family EVS87_007235 ENOG4105CSV Glutaminase EVS87_007245 ENOG4105CNI cell division protein FtsW EVS87_007250 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) EVS87_007255 ENOG4105CVP deoxyribo-dipyrimidine photolyase EVS87_007265 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) EVS87_007275 ENOG4105BZ9 Cytochrome C oxidase, subunit I EVS87_007280 ENOG4105CCU oxidase (Subunit III) EVS87_007285 ENOG41064X9 cytochrome C oxidase subunit IV EVS87_007300 ENOG41080XQ Signal transduction protein with cbs domains EVS87_007305 ENOG4106UY4 Inherit from COG: Scp-like extracellular EVS87_007330 ENOG4105WUC UPF0298 protein EVS87_007335 ENOG4106H78 methyltransferase EVS87_007340 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) EVS87_007345 ENOG4105H20 Sporulation integral membrane protein YlbJ EVS87_007350 ENOG4105D78 K07001 NTE family protein EVS87_007355 ENOG41063PX domain protein EVS87_007360 ENOG4105CDE UPF0348 protein EVS87_007365 ENOG4105KNH Nucleic acid-binding protein EVS87_007370 ENOG41067VY 50S ribosomal protein L32 EVS87_007395 ENOG4108V6E Cell division protein mraZ EVS87_007400 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) EVS87_007410 ENOG4105CJN penicillin-binding protein EVS87_007420 ENOG4105CJN penicillin-binding protein EVS87_007425 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EVS87_007430 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) EVS87_007435 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) EVS87_007440 ENOG4105CNI cell division protein FtsW EVS87_007445 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) EVS87_007450 ENOG4105D4A Cell wall formation (By similarity) EVS87_007455 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) EVS87_007460 ENOG4108R2U division initiation protein EVS87_007470 ENOG4105K67 small basic protein EVS87_007475 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EVS87_007480 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EVS87_007490 ENOG4105FFI sigma-e processing peptidase spoiiga EVS87_007495 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EVS87_007505 ENOG4105DKT Transcriptional regulator EVS87_007520 ENOG410787A Pts system, glucitol sorbitol-specific EVS87_007525 ENOG4105DZY Pts system, glucitol sorbitol-specific EVS87_007530 ENOG4105VI0 Pts system, glucitol sorbitol-specific EVS87_007535 ENOG4105DKW ABC transporter EVS87_007540 ENOG4105WR5 sporulation protein, YlmC YmxH family EVS87_007545 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EVS87_007550 ENOG4105DFA alanine racemase domain protein EVS87_007555 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) EVS87_007560 ENOG41067XK integral membrane protein EVS87_007565 ENOG4105DBK s4 domain protein EVS87_007575 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EVS87_007585 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) EVS87_007590 ENOG4105C34 Pseudouridine synthase EVS87_007595 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) EVS87_007605 ENOG4105CXT aspartate transcarbamylase EVS87_007610 ENOG4105CD3 dihydroorotase EVS87_007615 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EVS87_007620 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EVS87_007625 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) EVS87_007630 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) EVS87_007635 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) EVS87_007640 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) EVS87_007650 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) EVS87_007660 ENOG4107RIQ Sulfate adenylate transferase EVS87_007665 ENOG4108WF4 Catalyzes the synthesis of activated sulfate (By similarity) EVS87_007670 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) EVS87_007675 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein EVS87_007680 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein EVS87_007685 ENOG4105F23 Fibronectin-binding protein EVS87_007695 ENOG4105DSJ YicC domain protein EVS87_007700 ENOG4105KC4 UPF0296 protein EVS87_007705 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EVS87_007715 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EVS87_007720 ENOG4105C25 Primosomal protein n' EVS87_007725 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) EVS87_007730 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) EVS87_007735 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B EVS87_007740 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs EVS87_007745 ENOG4108ZF3 Phosphatase EVS87_007750 ENOG4105D9P serine threonine protein kinase EVS87_007755 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) EVS87_007760 ENOG4105DJV ribulose-phosphate 3-epimerase EVS87_007765 ENOG4105FJ0 thiamine EVS87_007775 ENOG4105VB9 50S ribosomal protein l28 EVS87_007780 ENOG4108ZAA Alkaline-shock protein EVS87_007785 ENOG4105DP4 dak2 domain fusion protein ylov EVS87_007795 ENOG4105EJQ L-serine dehydratase EVS87_007800 ENOG4105CB5 ATP-dependent DNA helicase recG EVS87_007805 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) EVS87_007810 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) EVS87_007815 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EVS87_007820 ENOG4105CHR reductase EVS87_007825 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EVS87_007830 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) EVS87_007835 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) EVS87_007840 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EVS87_007845 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) EVS87_007855 ENOG4105K5M 30s ribosomal protein S16 EVS87_007860 ENOG4108BW8 UPF0109 protein EVS87_007870 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) EVS87_007875 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) EVS87_007880 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) EVS87_007885 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) EVS87_007890 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EVS87_007900 ENOG4105VM1 flagellar EVS87_007905 ENOG4105CMV Succinyl-CoA synthetase subunit beta EVS87_007910 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EVS87_007915 ENOG4105C79 DNA protecting protein DprA EVS87_007920 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EVS87_007925 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) EVS87_007930 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EVS87_007935 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) EVS87_007940 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) EVS87_007950 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EVS87_007955 ENOG4108ZC9 flagellar basal-body rod protein flgc EVS87_007960 ENOG4105VQ0 flagellar hook-basal body complex protein fliE EVS87_007965 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EVS87_007970 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EVS87_007985 ENOG4106YF4 Flagellar biosynthesis chaperone EVS87_007995 ENOG410696Y Flagellar hook-length control protein EVS87_008000 ENOG410822I Flagellar hook capping protein EVS87_008005 ENOG4108JQA flagellar EVS87_008010 ENOG41068WV flagellar FlbD family protein EVS87_008020 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EVS87_008025 ENOG4105DD5 Flagellar motor switch protein EVS87_008030 ENOG4107YTP response regulator receiver protein EVS87_008040 ENOG4105CN7 Flagellar biosynthetic protein FliP EVS87_008045 ENOG4105VS8 Flagellar biosynthetic protein fliq EVS87_008050 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EVS87_008055 ENOG4105D00 flagellar biosynthetic protein flhB EVS87_008060 ENOG4105D7B Flagellar biosynthesis protein flha EVS87_008065 ENOG4105FZW flagellar biosynthesis regulator FlhF EVS87_008075 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EVS87_008080 ENOG4105CBS Chea signal transduction histidine kinase EVS87_008085 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis EVS87_008095 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) EVS87_008100 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EVS87_008110 ENOG4105CE9 30S ribosomal protein S2 EVS87_008115 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) EVS87_008125 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) EVS87_008130 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EVS87_008135 ENOG4105KNE Phosphatidate cytidylyltransferase EVS87_008140 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EVS87_008145 ENOG4105DZP Membrane-associated zinc metalloprotease EVS87_008150 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) EVS87_008155 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) EVS87_008165 ENOG4105CYP glycoside hydrolase, family EVS87_008170 ENOG4105WJF EVS87_008185 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) EVS87_008190 ENOG4105CHV Transcription elongation factor NusA EVS87_008195 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination EVS87_008200 ENOG4105VHM ribosomal protein EVS87_008205 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) EVS87_008210 ENOG4105W7A Protein of unknown function (DUF503) EVS87_008215 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) EVS87_008220 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EVS87_008225 ENOG4105DTN riboflavin biosynthesis protein ribF EVS87_008230 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) EVS87_008235 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) EVS87_008245 ENOG4105C1V Peptidase, M16 EVS87_008250 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EVS87_008260 ENOG4105BZ1 (ABC) transporter EVS87_008265 ENOG4105BZ1 (ABC) transporter EVS87_008300 ENOG4105DZH s-adenosylmethionine synthetase (EC 2.5.1.6) EVS87_008320 ENOG4105DTD Dehydrogenase EVS87_008325 ENOG41061TZ Short-chain dehydrogenase reductase Sdr EVS87_008330 ENOG4107RVV histidinol phosphate phosphatase, hisj family EVS87_008335 ENOG4105CZA synthase EVS87_008380 ENOG4105CAQ asparagine synthetase EVS87_008390 ENOG4105E35 Dipicolinate synthase subunit A EVS87_008395 ENOG4108S0H Dipicolinic acid synthetase, b subunit EVS87_008400 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EVS87_008410 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EVS87_008420 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit EVS87_008430 ENOG4105CNU cell division protein FtsK EVS87_008435 ENOG4105FDP GntR family transcriptional regulator EVS87_008445 ENOG4105EYF MMPL domain protein EVS87_008465 ENOG4105EYF MMPL domain protein EVS87_008470 ENOG4108RKS Short-chain dehydrogenase reductase Sdr EVS87_008475 ENOG4105XZV Protein of unknown function (DUF3243) EVS87_008490 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EVS87_008495 ENOG4105CEV competence damage-inducible protein EVS87_008500 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) EVS87_008505 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) EVS87_008510 ENOG4105D48 metallophosphoesterase EVS87_008515 ENOG4105MCT stage V sporulation protein S EVS87_008525 ENOG4105CPQ Dehydrogenase EVS87_008530 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EVS87_008535 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EVS87_008550 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) EVS87_008555 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EVS87_008575 ENOG4108VJ1 Transcriptional regulator (CarD family EVS87_008580 ENOG4105K7W phage-related replication protein EVS87_008590 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin EVS87_008595 ENOG4105K7W phage-related replication protein EVS87_008600 ENOG4108X3M OsmC Ohr family protein EVS87_008605 ENOG410814C multidrug resistance protein EVS87_008630 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) EVS87_008650 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) EVS87_008655 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EVS87_008660 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EVS87_008665 ENOG4105U6W MutT NUDIX family protein EVS87_008675 ENOG4106F1P AAA ATPase, central domain protein EVS87_008680 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EVS87_008685 ENOG4105CXI aluminum resistance protein EVS87_008690 ENOG4105KV4 Transcriptional regulator EVS87_008695 ENOG4105C5F glutamine synthetase EVS87_008760 ENOG4108ZMX Domain of unknown function (DU1801) EVS87_008780 ENOG410780I phosphoprotein phosphatase activity EVS87_008790 ENOG4105XPP Protein of unknown function (DUF1275) EVS87_008795 ENOG4105DQE DNA ligase EVS87_008800 ENOG4105FDF Could be involved in DNA repair (By similarity) EVS87_008805 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) EVS87_008815 ENOG4108Z40 Transcriptional regulator EVS87_008820 ENOG4105ECR NmrA family EVS87_008825 ENOG4107R5T Cysteine-rich domain EVS87_008830 ENOG4107QR9 Iron-sulfur cluster binding protein EVS87_008835 ENOG41080R8 Conserved Protein EVS87_008855 ENOG4108QY0 Membrane EVS87_008860 ENOG41082JN Transcriptional regulator EVS87_008865 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EVS87_008870 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases EVS87_008875 ENOG4105EDW glycosyl transferase, family 39 EVS87_008880 ENOG4105WFK nuclease EVS87_008885 ENOG4106SCS STAS domain EVS87_008900 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) EVS87_008910 ENOG4108SVB resolvase EVS87_008915 ENOG4105VPS UPF0291 protein EVS87_008920 ENOG4105CV1 Transketolase (EC 2.2.1.1) EVS87_008930 ENOG4105VXM UPF0154 protein EVS87_008940 ENOG4107QIV Cytochrome c biogenesis protein EVS87_008970 ENOG4108I0Z Aconitate hydratase EVS87_008975 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EVS87_009000 ENOG4105MI2 EVS87_009005 ENOG4105W8X HesB YadR YfhF-family protein EVS87_009010 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) EVS87_009015 ENOG4105K4P CoA-binding domain protein EVS87_009020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EVS87_009035 ENOG4106UW1 Major Facilitator superfamily EVS87_009040 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EVS87_009045 ENOG4108UW5 maltose o-acetyltransferase EVS87_009055 ENOG4107R5R arsenical pump membrane protein EVS87_009060 ENOG41082YX Transcriptional regulator, arsr family EVS87_009070 ENOG4107ZXU DSBA oxidoreductase EVS87_009075 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EVS87_009085 ENOG4105ST3 Transcriptional regulator EVS87_009090 ENOG4105DYS nad(p)h dehydrogenase (quinone) EVS87_009095 ENOG4105KVH Transcriptional regulator EVS87_009100 ENOG4105C6T cysteine synthase EVS87_009105 ENOG4105KME endoribonuclease L-psp EVS87_009120 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) EVS87_009150 ENOG4108Z6Z Transcriptional regulator EVS87_009155 ENOG4105CS2 ec 3.2.1.21 EVS87_009160 ENOG4105C5Y PTS System EVS87_009180 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EVS87_009190 ENOG4107SYN Glycosyl hydrolases family 43 EVS87_009205 ENOG4105I1K ABC transporter EVS87_009210 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component EVS87_009225 ENOG4105UP7 3-epimerase EVS87_009240 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia EVS87_009290 ENOG4105DM4 PTS System EVS87_009295 ENOG4105DM4 PTS System EVS87_009300 ENOG4105DE4 1-phosphofructokinase EVS87_009305 ENOG4105HX0 Transcriptional regulator EVS87_009310 ENOG4107RZC phospholipase d EVS87_009335 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) EVS87_009350 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EVS87_009355 ENOG4107QX3 carboxylase EVS87_009360 ENOG4105E39 Enoyl-CoA hydratase EVS87_009365 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase EVS87_009370 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit EVS87_009375 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EVS87_009380 ENOG4105CEY Amp-dependent synthetase and ligase EVS87_009385 ENOG4105C1G acyl-Coa dehydrogenase EVS87_009390 ENOG4105F32 YngK protein EVS87_009400 ENOG4105E98 transcriptional regulator DeoR family EVS87_009405 ENOG41090U3 tautomerase EVS87_009420 ENOG4105CQB FAD linked oxidase domain protein EVS87_009425 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EVS87_009435 ENOG4108B31 Spore germination protein EVS87_009455 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EVS87_009460 ENOG4107T5V SNARE associated Golgi EVS87_009465 ENOG4105EXQ uroporphyrinogen iii synthase hem4 EVS87_009475 ENOG4105DEN Luciferase family EVS87_009490 ENOG4107QJQ Mate efflux family protein EVS87_009495 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family EVS87_009500 ENOG4105NBR Pectinesterase EVS87_009505 ENOG4105H67 Protein of unknown function (DUF421) EVS87_009510 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit EVS87_009515 ENOG4108IFG nitrite reductase, (NAD(P)H) EVS87_009520 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EVS87_009535 ENOG4105BZ8 glutamate synthase EVS87_009540 ENOG4105CBC glutamate synthase EVS87_009545 ENOG4105C5Q Transcriptional regulator EVS87_009555 ENOG4105BZ1 (ABC) transporter EVS87_009560 ENOG41090E6 transcriptional regulator MERR family EVS87_009565 ENOG4108UYN gCN5-related N-acetyltransferase EVS87_009570 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) EVS87_009575 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) EVS87_009580 ENOG4105II7 pyrroline-5-carboxylate reductase EVS87_009590 ENOG4108J2R molybdopterin oxidoreductase EVS87_009600 ENOG4105CMG Carbohydrate kinase EVS87_009610 ENOG4105E2R ROK family EVS87_009620 ENOG4105CT4 transporter EVS87_009625 ENOG4108Z7R Chaperone CsaA EVS87_009635 ENOG4105FVX EVS87_009655 ENOG4108W8B Beta-lactamase domain protein EVS87_009665 ENOG4105D29 Helix-turn-helix type 11 domain protein EVS87_009675 ENOG4105KTU Transcriptional regulator, arsr family EVS87_009680 ENOG4105CUB amino acid EVS87_009690 ENOG4105CR4 methylisocitrate lyase EVS87_009695 ENOG4105DXD 2-methylcitrate dehydratase EVS87_009705 ENOG4108SJC Membrane EVS87_009715 ENOG41069ER domain protein EVS87_009720 ENOG4105C9U ATP-dependent DNA helicase RecQ EVS87_009730 ENOG4105SCY DNAK suppressor EVS87_009755 ENOG4105C26 Dehydrogenase EVS87_009765 ENOG4105EWU Squalene--hopene cyclase EVS87_009770 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EVS87_009775 ENOG4105C09 Bile acid EVS87_009780 ENOG4105C7S Dehydrogenase EVS87_009785 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EVS87_009790 ENOG4107T89 von Willebrand factor, type A EVS87_009795 ENOG4105GMT ATPase associated with various cellular activities aaa_5 EVS87_009805 ENOG4105K4H Nlp p60 protein EVS87_009835 ENOG4105FR1 rard protein EVS87_009865 ENOG4105E1V na solute symporter EVS87_009885 ENOG4108VXD carboxy-peptidase EVS87_009890 ENOG4105D3A purine nucleoside phosphorylase DeoD-type EVS87_009895 ENOG4106Z5R EVS87_009900 ENOG410841Q phosphoesterase PA-phosphatase related protein EVS87_009915 ENOG4105VSD UPF0346 protein EVS87_009925 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EVS87_009930 ENOG4108JUB Transcriptional regulator EVS87_009960 ENOG4105C5E polysaccharide biosynthesis protein EVS87_009965 ENOG4105E0X reductase EVS87_009970 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) EVS87_009995 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) EVS87_010000 ENOG41090WU lipolytic protein G-D-S-L family EVS87_010005 ENOG4108KF3 Electron transport protein SCO1 SenC EVS87_010020 ENOG4105C7B Threonine dehydratase EVS87_010030 ENOG4108UT2 hemolysin iii EVS87_010040 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) EVS87_010045 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) EVS87_010060 ENOG4107YX5 Pfam:DUF548 EVS87_010065 ENOG4108Y6J UPF0403 protein EVS87_010070 ENOG4105C01 Dihydroxy-acid dehydratase EVS87_010085 ENOG4108V06 Glutathione peroxidase EVS87_010090 ENOG4105CKU formyltetrahydrofolate synthetase EVS87_010095 ENOG4105CVG Homoserine O-transsuccinylase EVS87_010100 ENOG4108QBV Monogalactosyldiacylglycerol synthase EVS87_010135 ENOG41081VK Ribonuclease EVS87_010155 ENOG410890F Dynamin family EVS87_010170 ENOG41065KQ synthase EVS87_010175 ENOG4107VMI polysaccharide deacetylase EVS87_010180 ENOG4105C2W permease EVS87_010190 ENOG4105CTD carboxy-peptidase EVS87_010195 ENOG4105DVT helicase EVS87_010205 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EVS87_010215 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) EVS87_010220 ENOG4108UKS UPF0398 protein EVS87_010230 ENOG4107X2U Inherit from COG: Exonuclease-like protein EVS87_010235 ENOG4108I5C dEAD DEAH box helicase EVS87_010240 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EVS87_010280 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) EVS87_010285 ENOG4105BZ4 penicillin-binding protein EVS87_010295 ENOG4105CSM endonuclease III EVS87_010315 ENOG4105YAC EVS87_010320 ENOG4105DVT helicase EVS87_010325 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) EVS87_010330 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) EVS87_010335 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) EVS87_010345 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate EVS87_010350 ENOG4105CPK Glycosyl transferase (Group 1 EVS87_010355 ENOG4105FJR Lmbe family EVS87_010360 ENOG4108Z5K methylglyoxal synthase EVS87_010365 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) EVS87_010370 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase EVS87_010375 ENOG4108JYZ YitT family EVS87_010395 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) EVS87_010410 ENOG4108SXZ UPF0302 protein EVS87_010415 ENOG41068YB TPR repeat-containing protein EVS87_010420 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase EVS87_010430 ENOG4105CIH Imidazole acetol-phosphate transaminase EVS87_010435 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) EVS87_010440 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) EVS87_010445 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase EVS87_010450 ENOG4105DK0 Indole-3-glycerol phosphate synthase EVS87_010455 ENOG4108I0Q anthranilate phosphoribosyltransferase EVS87_010465 ENOG4105KHN chorismate mutase EVS87_010470 ENOG4105D49 3-dehydroquinate synthase EVS87_010475 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase EVS87_010480 ENOG4105BZU Histidine kinase EVS87_010485 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) EVS87_010490 ENOG4105EAH synthase EVS87_010495 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) EVS87_010500 ENOG4105XXQ heptaprenyl diphosphate synthase component I EVS87_010510 ENOG4105EUJ GTP cyclohydrolase i EVS87_010515 ENOG4105K70 DNA-binding protein EVS87_010520 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) EVS87_010535 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase EVS87_010540 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) EVS87_010545 ENOG41065D1 EVS87_010550 ENOG4105S2F EVS87_010575 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EVS87_010580 ENOG4105CAT Cytidine monophosphate kinase EVS87_010595 ENOG4105MSI germination protein ypeb EVS87_010605 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) EVS87_010610 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase EVS87_010625 ENOG4107RGJ metallophosphoesterase EVS87_010640 ENOG4105I7S Abortive infection protein EVS87_010645 ENOG4105C9U ATP-dependent DNA helicase RecQ EVS87_010650 ENOG4105T7X EVS87_010660 ENOG4108SAX Membrane EVS87_010665 ENOG4108JQ1 Dehydrogenase EVS87_010685 ENOG4105BZU Histidine kinase EVS87_010690 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EVS87_010695 ENOG4105CRE cytochrome C EVS87_010700 ENOG4107TWT Cytochrome c biogenesis protein EVS87_010710 ENOG4105FE9 pseudouridine synthase EVS87_010720 ENOG4108JIC nucleoside recognition domain protein EVS87_010725 ENOG4105DZ1 carboxypeptidase EVS87_010735 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) EVS87_010740 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) EVS87_010760 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EVS87_010765 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EVS87_010770 ENOG4108R6K riboflavin synthase, subunit alpha EVS87_010800 ENOG4107ZE5 PPIases accelerate the folding of proteins EVS87_010805 ENOG4105PTM secreted protein EVS87_010810 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EVS87_010820 ENOG4105G6R Stage v sporulation protein ae EVS87_010830 ENOG4105CZ3 stage V sporulation protein ad EVS87_010835 ENOG41090VF Stage v sporulation protein ac EVS87_010850 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EVS87_010855 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) EVS87_010860 ENOG41082AN stage II sporulation protein EVS87_010865 ENOG4105DZ1 carboxypeptidase EVS87_010870 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) EVS87_010875 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) EVS87_010880 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EVS87_010890 ENOG4105I3K Ferric uptake regulator, Fur family EVS87_010895 ENOG4105MZ9 stage II sporulation protein m EVS87_010910 ENOG4107YB6 acetyltransferase, (GNAT) family EVS87_010920 ENOG4108YZ4 nudix hydrolase EVS87_010925 ENOG4105CPC Aldo Keto reductase EVS87_010955 ENOG4106HZJ EVS87_010960 ENOG4108YQE rare lipoprotein a EVS87_010965 ENOG4105RHY Pfam:UPF0157 EVS87_010970 ENOG4108XET gCN5-related N-acetyltransferase EVS87_010980 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EVS87_010990 ENOG4105E5W Transporter EVS87_011000 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase EVS87_011010 ENOG4108IXY short-chain dehydrogenase reductase EVS87_011015 ENOG41069FQ Metallo-beta-lactamase superfamily EVS87_011020 ENOG4105II7 pyrroline-5-carboxylate reductase EVS87_011035 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EVS87_011045 ENOG4105XT2 Transcriptional regulator EVS87_011050 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) EVS87_011055 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EVS87_011060 ENOG4108TZY GntR Family Transcriptional Regulator EVS87_011065 ENOG4105CS2 ec 3.2.1.21 EVS87_011070 ENOG4105CK1 PTS System EVS87_011075 ENOG4105VCP PTS System EVS87_011080 ENOG4105VZJ PTS System EVS87_011090 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EVS87_011095 ENOG4105CSC Glucose uptake protein EVS87_011105 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EVS87_011110 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EVS87_011120 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) EVS87_011125 ENOG4108V3W Chemotaxis protein, CheW EVS87_011130 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EVS87_011135 ENOG4108HNZ carboxyl transferase EVS87_011140 ENOG4108ZVT methylmalonyl-coA epimerase EVS87_011150 ENOG4108VZI ErfK ybiS ycfS ynhG family protein EVS87_011155 ENOG4108QEG Membrane EVS87_011160 ENOG4105CDA abc transporter atp-binding protein EVS87_011165 ENOG4105E5Q amino acid AbC transporter EVS87_011170 ENOG4108HW3 (ABC) transporter EVS87_011175 ENOG4108Y6J UPF0403 protein EVS87_011180 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) EVS87_011190 ENOG4105C7S Dehydrogenase EVS87_011195 ENOG4105CPP Dehydrogenase, E1 component EVS87_011210 ENOG4105CKM Branched-chain carboxylic acid kinase EVS87_011215 ENOG4107RDP Dehydrogenase EVS87_011225 ENOG4108JUB Transcriptional regulator EVS87_011230 ENOG4106CCJ Protein of unknown function (DUF2627) EVS87_011235 ENOG4108QXE glycerophosphoryl diester phosphodiesterase EVS87_011245 ENOG4107QQR Sporulation EVS87_011250 ENOG4105S1Z Stage IV sporulation protein B EVS87_011255 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EVS87_011260 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) EVS87_011265 ENOG4105DX0 Hemolysin A EVS87_011270 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) EVS87_011275 ENOG4105CTB Polyprenyl synthetase EVS87_011280 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EVS87_011285 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) EVS87_011290 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) EVS87_011295 ENOG4105M7K Involved in the transcription termination process (By similarity) EVS87_011300 ENOG4108ZSR alkaline shock protein EVS87_011305 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EVS87_011325 ENOG410644B Stage III sporulation protein af EVS87_011335 ENOG4105KQ4 Stage iii sporulation protein ad EVS87_011340 ENOG4108CQH stage III sporulation protein AC EVS87_011345 ENOG4105KR5 Stage iii sporulation protein EVS87_011350 ENOG4105CD2 stage iii sporulation protein aa EVS87_011360 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) EVS87_011365 ENOG4105DC7 peptidase M24 EVS87_011370 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) EVS87_011380 ENOG4105CBJ Metal-dependent enzyme EVS87_011395 ENOG4105KST dependent repressor EVS87_011400 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) EVS87_011405 ENOG4105WZW rhodanese family EVS87_011420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EVS87_011425 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor EVS87_011435 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) EVS87_011440 ENOG4105C0D helicase EVS87_011465 ENOG4105VFR signal peptidase EVS87_011505 ENOG4106855 Competence protein EVS87_011540 ENOG4105C5X domain protein EVS87_011570 ENOG4105E0M Sulfatase EVS87_011585 ENOG4107ZXI Rhomboid family EVS87_011590 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EVS87_011595 ENOG4105WDJ 50S ribosomal protein L33 EVS87_011605 ENOG41068DG YceG-like family EVS87_011610 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EVS87_011615 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EVS87_011620 ENOG4105E2Z phosphate ABC transporter (Permease EVS87_011625 ENOG4105C8U phosphate abc transporter EVS87_011630 ENOG4105CVA phosphate EVS87_011635 ENOG4107RF6 penicillin-binding protein EVS87_011645 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EVS87_011650 ENOG4105SXS Protein of unknown function (DUF456) EVS87_011660 ENOG4105D9U N-acetyltransferase EVS87_011670 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) EVS87_011675 ENOG41063Y9 EVS87_011680 ENOG4108U5J '-nucleotidase EVS87_011685 ENOG41066F8 ROK family EVS87_011690 ENOG4105N80 Ferric uptake regulator, Fur family EVS87_011695 ENOG4105FAV ABC, transporter EVS87_011700 ENOG4105FDK ABC transporter EVS87_011705 ENOG4108JYZ YitT family EVS87_011710 ENOG41069ZM Protein of unknown function (DUF2624) EVS87_011715 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) EVS87_011730 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) EVS87_011735 ENOG4105EGD dinuclear metal center protein, YbgI family EVS87_011750 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EVS87_011755 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EVS87_011760 ENOG4108UPT UPF0178 protein EVS87_011765 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) EVS87_011775 ENOG4105C38 Glycyl-tRNA synthetase beta subunit EVS87_011780 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit EVS87_011785 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) EVS87_011795 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) EVS87_011800 ENOG4105KG3 cytidine deaminase EVS87_011805 ENOG4107YR5 Diacylglycerol kinase EVS87_011810 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) EVS87_011815 ENOG4105CTJ Metal Dependent Phosphohydrolase EVS87_011820 ENOG4105C9A Phoh family EVS87_011825 ENOG4105EI1 sporulation protein yqfd EVS87_011830 ENOG41068P3 sporulation protein YqfC EVS87_011845 ENOG4105DI5 UPF0365 protein EVS87_011850 ENOG4105F7J membrane-bound serine protease EVS87_011855 ENOG4105KTH gatB Yqey EVS87_011870 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) EVS87_011875 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EVS87_011880 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) EVS87_011885 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EVS87_011895 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ EVS87_011900 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) EVS87_011905 ENOG4105CSA Coproporphyrinogen iii oxidase EVS87_011910 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) EVS87_011920 ENOG4108ZRV stage ii sporulation protein p EVS87_011935 ENOG4105TQK DNA polymerase iii, delta' subunit EVS87_011945 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 EVS87_011950 ENOG4108UK2 deaminase EVS87_011955 ENOG4105KQC Competence protein EVS87_011965 ENOG4108D32 Methyltransferase EVS87_011975 ENOG4108WF2 Metal Dependent Phosphohydrolase EVS87_011980 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) EVS87_011985 ENOG410812S Rna-binding protein EVS87_011990 ENOG4105E2X shikimate dehydrogenase EVS87_011995 ENOG4105CQW ribosome biogenesis GTPase YqeH EVS87_012000 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase EVS87_012015 ENOG4108ZJ4 polysaccharide deacetylase EVS87_012025 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EVS87_012030 ENOG4107Y5K Resolvase EVS87_012080 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EVS87_012115 ENOG410906S phage-like element pbsx protein xkdt EVS87_012120 ENOG41066EA baseplate J family protein EVS87_012125 ENOG4105MFU Protein of unknown function (DUF2634) EVS87_012135 ENOG4105X7F EVS87_012140 ENOG4108WZM domain protein EVS87_012145 ENOG4108FKH Transglycosylase SLT domain EVS87_012145 ENOG4108FKH Transglycosylase SLT domain EVS87_012150 ENOG4105MTC XkdN-like protein EVS87_012160 ENOG4105FR7 XkdM protein, phage-like element PBSX EVS87_012165 ENOG4105PQS phage protein EVS87_012180 ENOG41060SN EVS87_012225 ENOG4106CGH Phage Mu protein F like protein EVS87_012230 ENOG4108MDF Phage Portal Protein EVS87_012235 ENOG4105IG6 Phage terminase, large subunit EVS87_012315 ENOG4105QBX endodeoxyribonuclease RusA EVS87_012325 ENOG4106CVF DNA replication protein EVS87_012380 ENOG410635T phage-like element pbsx protein EVS87_012400 ENOG4107YCY Transcriptional regulator EVS87_012420 ENOG4108IUS Transketolase EVS87_012425 ENOG4108HHA Transketolase EVS87_012450 ENOG4108ZJ4 polysaccharide deacetylase EVS87_012485 ENOG4105CJ1 ABC, transporter EVS87_012505 ENOG4107QNK )-transporter EVS87_012510 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) EVS87_012525 ENOG4105CMD Transcriptional regulator, GntR family EVS87_012535 ENOG4105NTK Transcriptional repressor Mpra EVS87_012545 ENOG41080HJ 6-phospho 3-hexuloisomerase EVS87_012550 ENOG4108VA3 3-hexulose-6-phosphate synthase EVS87_012555 ENOG4105KVH Transcriptional regulator EVS87_012575 ENOG4105CNA YD repeat protein EVS87_012580 ENOG4108HWY Beta-lactamase EVS87_012585 ENOG4105FDT acyl-CoA dehydrogenase EVS87_012605 ENOG4105E5Q amino acid AbC transporter EVS87_012620 ENOG4107EXU Short-chain dehydrogenase reductase Sdr EVS87_012625 ENOG4105E2A Dehydrogenase EVS87_012655 ENOG4105C28 cystathionine EVS87_012665 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) EVS87_012670 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) EVS87_012685 ENOG4107XRG penicillin-binding protein EVS87_012690 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EVS87_012695 ENOG4107S03 uridine kinase EVS87_012700 ENOG4105CFP Peptidase U32 EVS87_012705 ENOG4105XYU peptidase (U32 family) EVS87_012710 ENOG4108VQJ O-methyltransferase EVS87_012715 ENOG4105HHA aminodeoxychorismate lyase EVS87_012725 ENOG4107F3J Amp-dependent synthetase and ligase EVS87_012730 ENOG4107ZYJ bioY protein EVS87_012735 ENOG4105VPH UPF0473 protein EVS87_012740 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) EVS87_012745 ENOG4105VBH UPF0297 protein EVS87_012755 ENOG4105C02 permease EVS87_012760 ENOG4105CDA abc transporter atp-binding protein EVS87_012765 ENOG4105CT1 (ABC) transporter EVS87_012770 ENOG4105EAD ABC transporter EVS87_012775 ENOG4105DRP amino acid AbC transporter EVS87_012785 ENOG41060CR EVS87_012795 ENOG4105C7H Helicase, RecD TraA family EVS87_012805 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) EVS87_012810 ENOG4105C3J Cysteine desulfurase EVS87_012820 ENOG4105D1H recombination factor protein RarA EVS87_012825 ENOG4105CUZ uba thif-type nad fad binding protein EVS87_012835 ENOG4105C9M aspartyl-trna synthetase EVS87_012840 ENOG4105CUT histidyl-tRNA synthetase EVS87_012845 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EVS87_012850 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) EVS87_012855 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EVS87_012860 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) EVS87_012865 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EVS87_012870 ENOG41067VP Protein of unknown function (DUF1049) EVS87_012875 ENOG4105NCW Trka-c domain protein EVS87_012880 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EVS87_012890 ENOG4105CKP Polysaccharide Biosynthesis Protein EVS87_012895 ENOG4108QG2 Membrane EVS87_012900 ENOG4105NAP EVS87_012905 ENOG4105VIE preprotein translocase, subunit YajC EVS87_012910 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) EVS87_012915 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) EVS87_012920 ENOG41061AI Protein of unknown function (DUF2905) EVS87_012925 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) EVS87_012930 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) EVS87_012950 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) EVS87_012965 ENOG4106678 morphogenetic protein associated with SpoVID EVS87_012970 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) EVS87_012975 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EVS87_012980 ENOG4108IYU L-aspartate oxidase EVS87_012995 ENOG4105CQC Prephenate dehydratase EVS87_013005 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EVS87_013015 ENOG4105K46 50S ribosomal protein l27 EVS87_013020 ENOG4105X36 (ribosomal) protein EVS87_013025 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) EVS87_013040 ENOG4107QMS site-determining protein EVS87_013045 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) EVS87_013050 ENOG4105YHC Rod shape-determining protein MreD EVS87_013055 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) EVS87_013060 ENOG4105DFF Rod shape-determining protein mreb EVS87_013065 ENOG4105W5Q DNA repair protein (RadC EVS87_013070 ENOG4108Z03 MAF-like protein EVS87_013080 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) EVS87_013085 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EVS87_013090 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EVS87_013100 ENOG4106AR7 Spore coat protein EVS87_013105 ENOG41068KH stage VI sporulation protein D EVS87_013110 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase EVS87_013115 ENOG4105D52 delta-aminolevulinic acid dehydratase EVS87_013125 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) EVS87_013135 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EVS87_013145 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) EVS87_013150 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EVS87_013155 ENOG4108IUQ atp-dependent protease EVS87_013160 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) EVS87_013165 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation EVS87_013175 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EVS87_013180 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) EVS87_013185 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EVS87_013190 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) EVS87_013195 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase EVS87_013200 ENOG4108ZP8 Acetolactate synthase small subunit EVS87_013205 ENOG4105C7K acetolactate synthase EVS87_013210 ENOG4105CM2 brancheD-chain amino acid aminotransferase EVS87_013215 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) EVS87_013225 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD EVS87_013235 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein EVS87_013240 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) EVS87_013310 ENOG4105M59 Phosphodiesterase, mj0936 family EVS87_013315 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EVS87_013320 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) EVS87_013325 ENOG4108XJQ germination protein EVS87_013330 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) EVS87_013335 ENOG41067TZ transcriptional regulator, MarR family EVS87_013340 ENOG4105PFC Transcriptional regulator EVS87_013350 ENOG4108KAM Transcriptional regulator EVS87_013355 ENOG4105C7F AcnD-accessory protein PrpF EVS87_013360 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase EVS87_013370 ENOG4105E33 succinate dehydrogenase EVS87_013380 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit EVS87_013395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EVS87_013400 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EVS87_013410 ENOG4105CFH Aspartokinase EVS87_013415 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) EVS87_013420 ENOG4105K63 Thioredoxin EVS87_013425 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) EVS87_013430 ENOG4105C10 Electron transfer flavoprotein EVS87_013435 ENOG4105BZJ Electron transfer flavoprotein EVS87_013440 ENOG41060WC Enoyl-CoA hydratase EVS87_013445 ENOG4107Z3H Transcriptional regulator, TetR family EVS87_013450 ENOG4105CEY Amp-dependent synthetase and ligase EVS87_013465 ENOG4105C98 muts2 protein EVS87_013470 ENOG4105DCG PHP domain protein EVS87_013480 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) EVS87_013485 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) EVS87_013490 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EVS87_013495 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) EVS87_013500 ENOG4108RWN rrna methyltransferase EVS87_013505 ENOG41067MF small acid-soluble spore protein EVS87_013515 ENOG4105CN9 Peptidase m42 family protein EVS87_013525 ENOG410696E Membrane EVS87_013530 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EVS87_013535 ENOG4105VJV 50s ribosomal protein L35 EVS87_013540 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) EVS87_013545 ENOG41067MG lrgb family EVS87_013555 ENOG4105DY9 regulatoR EVS87_013560 ENOG4108HRK Histidine kinase EVS87_013565 ENOG4105U0R haloacid dehalogenase-like hydrolase EVS87_013570 ENOG4107SDU Methyl-accepting chemotaxis EVS87_013575 ENOG4105C22 threonyL-tRNA synthetase EVS87_013580 ENOG4108TDW sporulation protein YtxC EVS87_013600 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) EVS87_013610 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) EVS87_013615 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EVS87_013620 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EVS87_013630 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) EVS87_013635 ENOG4105C2M dna polymerase I EVS87_013640 ENOG4105BZU Histidine kinase EVS87_013645 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EVS87_013650 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) EVS87_013655 ENOG4108HMX isocitrate dehydrogenase (NADP) EVS87_013660 ENOG4105BZN citrate synthase EVS87_013665 ENOG4107CWS Protein of unknown function (DUF441) EVS87_013670 ENOG4108REF Sporulation integral membrane protein ytvi EVS87_013675 ENOG4105FS0 cytoplasmic membrane protein EVS87_013680 ENOG4105CA9 Pyruvate kinase EVS87_013685 ENOG4105CTQ phosphohexokinase EVS87_013695 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) EVS87_013700 ENOG4105C6K Malic enzyme EVS87_013705 ENOG4105C0B DNA polymerase III (alpha subunit) EVS87_013710 ENOG4105VV2 EVS87_013720 ENOG4106EVM EVS87_013725 ENOG4105SFS phosphoesterase RecJ domain protein EVS87_013745 ENOG4105E8R UPF0173 metal-dependent hydrolase EVS87_013760 ENOG4105CH7 arginosuccinase EVS87_013765 ENOG4105CDH Citrulline--aspartate ligase EVS87_013770 ENOG4105EPU Molybdenum cofactor synthesis domain protein EVS87_013775 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EVS87_013785 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) EVS87_013790 ENOG4105KBJ sporulation protein ytfj EVS87_013800 ENOG4105VK3 rdd domain containing protein EVS87_013805 ENOG4105D07 Signal peptide peptidase, SppA EVS87_013810 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) EVS87_013815 ENOG4105C1J atp-dependent rna helicase EVS87_013820 ENOG4105ECK Fatty Acid Desaturase EVS87_013825 ENOG4108ZGX Histidine kinase EVS87_013830 ENOG4108S01 response regulator EVS87_013840 ENOG4105CJZ response regulator EVS87_013845 ENOG4105EWM Histidine kinase EVS87_013850 ENOG4105CNI cell division protein FtsW EVS87_013860 ENOG4105C19 ABC transporter EVS87_013870 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) EVS87_013875 ENOG4108X0B nad(p)h dehydrogenase (quinone) EVS87_013890 ENOG4108ZUB Lysine exporter protein (Lyse ygga) EVS87_013895 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EVS87_013905 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) EVS87_013935 ENOG4105U5Y Transcriptional regulator EVS87_013945 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EVS87_013965 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold EVS87_013970 ENOG4105KAC Antibiotic biosynthesis monooxygenase EVS87_013975 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) EVS87_013985 ENOG4105F1V Acetoin utilization protein EVS87_013990 ENOG4105W87 Cbs domain EVS87_013995 ENOG4105DGU Histone deacetylase EVS87_014000 ENOG4105ETE Transcriptional regulator (LacI family EVS87_014005 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase EVS87_014025 ENOG4105DFU Cell wall formation (By similarity) EVS87_014035 ENOG4108VDD TRNA binding domain protein EVS87_014040 ENOG4108NKM UPF0354 protein EVS87_014055 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ EVS87_014070 ENOG4105C6K Malic enzyme EVS87_014075 ENOG4105C8F Beta-lactamase domain protein EVS87_014080 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) EVS87_014090 ENOG4108V15 phosphotransferase enzyme family EVS87_014105 ENOG4107F58 2'-5' rna ligase EVS87_014110 ENOG4105C6T cysteine synthase EVS87_014115 ENOG4107XNU peptidase EVS87_014120 ENOG4107QSE Dipeptidase EVS87_014125 ENOG4105C7N Xanthine uracil vitamin C permease EVS87_014130 ENOG4105YW5 deoR family transcriptional regulator EVS87_014145 ENOG4105CBX hi0933 family EVS87_014155 ENOG4105C94 Transporter EVS87_014160 ENOG4106611 bacteriocin immunity EVS87_014170 ENOG41085GJ domain protein EVS87_014175 ENOG4105MU9 integral membrane protein EVS87_014180 ENOG4105DDC Oxidoreductase domain protein EVS87_014190 ENOG4105F5H Glycosyl Hydrolase Family 88 EVS87_014200 ENOG41075H3 AraC family transcriptional regulator EVS87_014205 ENOG4105KVH Transcriptional regulator EVS87_014210 ENOG4105F27 Major Facilitator EVS87_014215 ENOG4105CV8 reductase EVS87_014225 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component EVS87_014235 ENOG4105NTD Inherit from COG: Hydrolase EVS87_014240 ENOG4105C8T Leucyl-tRNA synthetase EVS87_014250 ENOG4105BZU Histidine kinase EVS87_014255 ENOG4106UBQ EVS87_014260 ENOG4107R34 abc transporter permease protein EVS87_014275 ENOG4105DVE abc transporter atp-binding protein EVS87_014280 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family EVS87_014300 ENOG4105N5T Radical SAM Protein EVS87_014310 ENOG4108N23 SpoOM-related protein EVS87_014320 ENOG4105E8V Alpha Beta Hydrolase Fold protein EVS87_014325 ENOG4108Z0R Transferase EVS87_014330 ENOG4105CAQ asparagine synthetase EVS87_014335 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EVS87_014355 ENOG4105EWK phytoene EVS87_014375 ENOG4105D2X ABC transporter substrate-binding protein EVS87_014385 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component EVS87_014395 ENOG4106FN3 tellurium resistance protein EVS87_014420 ENOG4108RMU ferritin dps family protein EVS87_014435 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) EVS87_014440 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) EVS87_014445 ENOG4108V2W Carbonate dehydratase EVS87_014450 ENOG4105DSE periplasmic solute binding protein EVS87_014455 ENOG4105NRA 50s ribosomal protein l31 type b EVS87_014485 ENOG4105DTQ mandelate racemase muconate lactonizing EVS87_014495 ENOG4108IPT Naphthoate synthase EVS87_014500 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) EVS87_014505 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) EVS87_014510 ENOG4105E4F Isochorismate synthase EVS87_014515 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EVS87_014525 ENOG4108606 TspO/MBR family EVS87_014650 ENOG4105N67 Proton-coupled thiamine transporter YuaJ EVS87_014660 ENOG4105VRR gCN5-related N-acetyltransferase EVS87_014670 ENOG4105CNI cell division protein FtsW EVS87_014680 ENOG4105DZ6 Band 7 protein EVS87_014690 ENOG4106DF1 EVS87_014695 ENOG4108JB8 alcohol dehydrogenase EVS87_014700 ENOG4105C26 Dehydrogenase EVS87_014705 ENOG4105TRT Transcriptional regulator EVS87_014720 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase EVS87_014735 ENOG41068G1 EVS87_014750 ENOG410906S phage-like element pbsx protein xkdt EVS87_014755 ENOG41066EA baseplate J family protein EVS87_014760 ENOG4105MFU Protein of unknown function (DUF2634) EVS87_014770 ENOG4105X7F EVS87_014775 ENOG4108WZM domain protein EVS87_014780 ENOG4108FKH Transglycosylase SLT domain EVS87_014780 ENOG4108FKH Transglycosylase SLT domain EVS87_014790 ENOG4105MTC XkdN-like protein EVS87_014800 ENOG4105FR7 XkdM protein, phage-like element PBSX EVS87_014805 ENOG4105PQS phage protein EVS87_014820 ENOG41060SN EVS87_014845 ENOG4108MDF Phage Portal Protein EVS87_014850 ENOG4105IG6 Phage terminase, large subunit EVS87_014870 ENOG4105QBX endodeoxyribonuclease RusA EVS87_014895 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) EVS87_014905 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EVS87_014920 ENOG4105EE0 oxidoreductase EVS87_014925 ENOG4108Z0Z intracellular protease Pfpi family EVS87_014930 ENOG4105C8Q Methyl-accepting chemotaxis EVS87_014935 ENOG4105C8Q Methyl-accepting chemotaxis EVS87_014940 ENOG4105C8Q Methyl-accepting chemotaxis EVS87_014945 ENOG4105C8Q Methyl-accepting chemotaxis EVS87_014960 ENOG4105EA8 2-Nitropropane dioxygenase EVS87_014965 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme EVS87_014970 ENOG4105C37 (CBS) domain EVS87_014985 ENOG4107PBV potassium channel EVS87_015000 ENOG4107QYV phosphohexose isomerase EVS87_015010 ENOG4107QW4 alcohol dehydrogenase EVS87_015015 ENOG4105WG9 Conserved Protein EVS87_015025 ENOG4105CHM Aminotransferase EVS87_015030 ENOG4108ZB6 transcriptional regulator AsnC family EVS87_015035 ENOG4108MUZ hydrolase EVS87_015045 ENOG4105C87 Aminotransferase class I and II EVS87_015050 ENOG4108HGU Histidine kinase EVS87_015055 ENOG4105Y38 Kinase-associated protein B EVS87_015070 ENOG4105BZ4 penicillin-binding protein EVS87_015075 ENOG4105KIR Thiol-disulfide oxidoreductase dcc EVS87_015090 ENOG4108MRH transcriptional regulatory protein EVS87_015095 ENOG4105DIH basic membrane EVS87_015100 ENOG4108JQ9 ABC transporter EVS87_015105 ENOG4105UIB (ABC) transporter EVS87_015130 ENOG4105D65 subunit l EVS87_015135 ENOG4105HC0 Na H antiporter EVS87_015140 ENOG4108ZE9 Monovalent cation H antiporter subunit C EVS87_015145 ENOG4108JPZ Monovalent cation H antiporter subunit D EVS87_015150 ENOG4105SC1 monovalent cation H antiporter subunit E EVS87_015160 ENOG4105KJM monovalent cation h antiporter subunit g EVS87_015165 ENOG4105KA0 thioesterase Superfamily protein EVS87_015175 ENOG4105BZU Histidine kinase EVS87_015200 ENOG4105D58 Diguanylate phosphodiesterase EVS87_015205 ENOG4105DAP Nicotinate phosphoribosyltransferase EVS87_015235 ENOG4105C02 permease EVS87_015255 ENOG410904N short-chain dehydrogenase reductase EVS87_015290 ENOG4108K8K Transcriptional regulator EVS87_015295 ENOG4105DCF alanine dehydrogenase EVS87_015310 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) EVS87_015320 ENOG41069ER domain protein EVS87_015330 ENOG4105CEP NADH dehydrogenase EVS87_015335 ENOG4105CAY ferredoxin--nadp reductase EVS87_015350 ENOG4107TXC Transcriptional regulator EVS87_015360 ENOG4108YX9 iron--sulfur cluster insertion protein erpA EVS87_015365 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) EVS87_015370 ENOG4105ZKE UPF0349 protein EVS87_015390 ENOG41083MR nifu domain-containing protein EVS87_015395 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein EVS87_015405 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) EVS87_015410 ENOG4105D6E homoserine dehydrogenase EVS87_015415 ENOG4105C5I Dehydrogenase EVS87_015425 ENOG4108W5N phosphatidylglycerophosphatase a EVS87_015430 ENOG4105D4U had-superfamily hydrolase, subfamily iia EVS87_015440 ENOG4105MMD transcriptional regulator EVS87_015445 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) EVS87_015455 ENOG4105FAA peptidase M23 EVS87_015470 ENOG4108YTE sporulation protein YunB EVS87_015475 ENOG4105KZD Domain of unknown function (DUF1805) EVS87_015480 ENOG4107R8B 5'-nucleotidase EVS87_015485 ENOG4105I3N Conserved Protein EVS87_015490 ENOG4105G9B Transcriptional regulator EVS87_015495 ENOG4105F0F Oxalate decarboxylase EVS87_015505 ENOG4105C5R Aminotransferase EVS87_015510 ENOG4108K8S endonuclease I EVS87_015520 ENOG4108IHU transport system permease protein EVS87_015525 ENOG4105DQ5 transport system permease protein EVS87_015530 ENOG4108MES Periplasmic binding protein EVS87_015550 ENOG4108SWU Histidine kinase EVS87_015555 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EVS87_015560 ENOG4105DHF Membrane EVS87_015570 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) EVS87_015580 ENOG4108IG5 Transcriptional regulator EVS87_015585 ENOG4105DIW FeS assembly protein SUFB EVS87_015590 ENOG4108UNV SUF system FeS assembly protein, NifU family EVS87_015595 ENOG4105C9B Cysteine desulfurase EVS87_015600 ENOG4105JRK feS assembly protein SufD EVS87_015605 ENOG4105C3K feS assembly ATPase SufC EVS87_015615 ENOG4105D01 (LipO)protein EVS87_015620 ENOG4108UMI ABC transporter, permease EVS87_015625 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EVS87_015650 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) EVS87_015655 ENOG41080E8 Transcriptional regulator, Spx MgsR family EVS87_015660 ENOG4105C1G acyl-Coa dehydrogenase EVS87_015665 ENOG4105CHU acetyl-coa acetyltransferase EVS87_015695 ENOG4105E0A ABC, transporter EVS87_015705 ENOG4105E1F short-chain dehydrogenase reductase EVS87_015715 ENOG4105C0H protease EVS87_015725 ENOG4105F3H Histidine kinase EVS87_015730 ENOG41067SE Tetr family transcriptional regulator EVS87_015735 ENOG4105C9Q fumarate hydratase class II EVS87_015765 ENOG4105WH1 Two component transcriptional regulator luxr family EVS87_015770 ENOG4105ENE Histidine kinase EVS87_015785 ENOG41087YS Phage shock protein A EVS87_015795 ENOG4108WBT adenosyltransferase EVS87_015800 ENOG4105E0A ABC, transporter EVS87_015805 ENOG4105EHG Permease protein EVS87_015810 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EVS87_015820 ENOG4105CTX dehydratase EVS87_015825 ENOG4107QZW Altronate oxidoreductase EVS87_015830 ENOG4107KJX Transcriptional regulator EVS87_015835 ENOG4105D2H Uronic isomerase EVS87_015845 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EVS87_015850 ENOG4105E0A ABC, transporter EVS87_015855 ENOG4105EHG Permease protein EVS87_015860 ENOG4105DQ5 transport system permease protein EVS87_015870 ENOG4105D5Q Arginine ornithine antiporter EVS87_015890 ENOG4107K5X Membrane-bound metal-dependent hydrolase EVS87_015895 ENOG4107QZ2 Sulfatase EVS87_015900 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EVS87_015905 ENOG4105E0C molybdate abc transporter EVS87_015920 ENOG4105EVU fructokinase EVS87_015925 ENOG4107SUZ Sodium/hydrogen exchanger family EVS87_015930 ENOG4105EN6 Membrane EVS87_015940 ENOG4107ZQN disulfide bond EVS87_015945 ENOG4105C59 p-type ATPase EVS87_015950 ENOG4105DIK (ABC) transporter EVS87_015955 ENOG4105CC5 ABC transporter EVS87_015960 ENOG4105DSE periplasmic solute binding protein EVS87_015965 ENOG4105IIP Membrane EVS87_015970 ENOG4105W1N transcriptional regulator EVS87_015985 ENOG4108IJ0 Aspartate ammonia-lyase EVS87_015995 ENOG4105C59 p-type ATPase EVS87_016000 ENOG410681U heavy metal transport detoxification protein EVS87_016005 ENOG4105VPX protein, conserved in bacteria EVS87_016015 ENOG4105BZU Histidine kinase EVS87_016035 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) EVS87_016040 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EVS87_016050 ENOG4105XZU Preprotein translocase, subunit SecG EVS87_016075 ENOG4105KVH Transcriptional regulator EVS87_016080 ENOG4105R40 Glycine betaine carnitine choline EVS87_016085 ENOG4108HQR Glycine betaine EVS87_016090 ENOG4105E90 ABC transporter EVS87_016095 ENOG4108IJ8 ABC transporter EVS87_016100 ENOG4107HG4 Transcriptional regulator EVS87_016105 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein EVS87_016115 ENOG4108W0I acetyltransferase EVS87_016145 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) EVS87_016155 ENOG4105CP7 Triose-phosphate isomerase EVS87_016160 ENOG4105BZA Phosphoglycerate kinase EVS87_016165 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EVS87_016180 ENOG4105C8Y Acetylornithine aminotransferase EVS87_016185 ENOG4108JUB Transcriptional regulator EVS87_016190 ENOG4105JXH GntR family transcriptional regulator EVS87_016195 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EVS87_016205 ENOG4107R73 Mate efflux family protein EVS87_016210 ENOG4108JQ7 (ABC) transporter EVS87_016215 ENOG4105C3U ABC transporter EVS87_016220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EVS87_016225 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EVS87_016230 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein EVS87_016235 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EVS87_016240 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family EVS87_016245 ENOG4105D3Q Sugar transferase EVS87_016260 ENOG4107QRS glycosyltransferase group 2 family protein EVS87_016265 ENOG41068W6 Capsular polysaccharide biosynthesis protein EVS87_016270 ENOG4108KMV Glycosyl transferase (Group 1 EVS87_016275 ENOG4105K64 Glycosyl transferase, family 2 EVS87_016280 ENOG4108PQP glycosyl transferase group 1 EVS87_016290 ENOG4108QV3 biosynthesis protein EVS87_016295 ENOG4105HTX biosynthesis protein EVS87_016310 ENOG4108V5C ABC transporter EVS87_016315 ENOG4105EHG Permease protein EVS87_016320 ENOG4105DQ5 transport system permease protein EVS87_016325 ENOG4108ZJ4 polysaccharide deacetylase EVS87_016360 ENOG4107R3N Filamentation induced by cAMP protein fic EVS87_016380 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) EVS87_016385 ENOG4108URH decarboxylase EVS87_016390 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain EVS87_016395 ENOG4105CHH sulfate transporter EVS87_016400 ENOG4108V2W Carbonate dehydratase EVS87_016405 ENOG4105C5I Dehydrogenase EVS87_016415 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase EVS87_016420 ENOG4105KRI phosphocarrier protein (HPr EVS87_016425 ENOG4105CIE May be required for sporulation (By similarity) EVS87_016430 ENOG4105CHW UPF0052 protein EVS87_016435 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) EVS87_016440 ENOG4108Z4K mutator MutT protein EVS87_016445 ENOG4105C3M thioredoxin reductase EVS87_016460 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EVS87_016465 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) EVS87_016470 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase EVS87_016475 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EVS87_016480 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EVS87_016485 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) EVS87_016490 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) EVS87_016495 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) EVS87_016510 ENOG4108RYK Nad-dependent epimerase dehydratase EVS87_016515 ENOG4108Z40 Transcriptional regulator EVS87_016520 ENOG4108S4C acetyltransferase EVS87_016525 ENOG4107XGZ Hydrolase EVS87_016530 ENOG4105HKU nucleoside recognition domain-containing protein EVS87_016535 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) EVS87_016540 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) EVS87_016545 ENOG4105CE4 GlcNAc 6-P deacetylase EVS87_016550 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) EVS87_016555 ENOG4105FDP GntR family transcriptional regulator EVS87_016560 ENOG41088CQ domain protein EVS87_016565 ENOG41086DT Membrane protein of unknown function EVS87_016570 ENOG41067S9 phage shock protein C, PspC EVS87_016575 ENOG4108PY7 EVS87_016595 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EVS87_016600 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) EVS87_016615 ENOG4105MKU Transcriptional regulator EVS87_016630 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EVS87_016635 ENOG4105BZU Histidine kinase EVS87_016640 ENOG4105EDW glycosyl transferase, family 39 EVS87_016645 ENOG4105CKK Glycosyl transferase, family 2 EVS87_016655 ENOG4108RCM Nitroreductase EVS87_016660 ENOG4105KVH Transcriptional regulator EVS87_016675 ENOG4105CN1 protease EVS87_016690 ENOG4105CRP Part of the ABC transporter FtsEX involved in EVS87_016695 ENOG4105CAK Cell division ATP-binding protein ftsE EVS87_016730 ENOG4105MS2 ribosomal subunit Interface protein EVS87_016735 ENOG4105C8Q Methyl-accepting chemotaxis EVS87_016750 ENOG4105MQ3 flagellar protein FliS EVS87_016755 ENOG4107RT6 flagellar hook-associated EVS87_016760 ENOG41083S7 flagellar protein FlaG EVS87_016765 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) EVS87_016770 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) EVS87_016775 ENOG4105MKD EVS87_016780 ENOG4105DTJ flagellar hook-associated protein EVS87_016785 ENOG4105E1Q flagellar hook-associated protein EVS87_016800 ENOG4105RU3 EVS87_016805 ENOG41081UC Inherit from COG: Competence protein EVS87_016825 ENOG4105WH1 Two component transcriptional regulator luxr family EVS87_016830 ENOG4105BZU Histidine kinase EVS87_016835 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EVS87_016840 ENOG4108KGH TRANSCRIPTIONal EVS87_016845 ENOG4105ESV Glycosyl transferase, family 4 EVS87_016850 ENOG4107EF8 Glycosyl transferase (Group 1 EVS87_016865 ENOG4105QZI O-Antigen Polymerase EVS87_016870 ENOG4105C1B dTDP-glucose 4-6-dehydratase EVS87_016875 ENOG4105C6Y Udp-glucose 6-dehydrogenase EVS87_016880 ENOG4107RA4 Glycosyl transferase (Group 1 EVS87_016885 ENOG4105PSV Polysaccharide Biosynthesis Protein EVS87_016890 ENOG4105D3Q Sugar transferase EVS87_016900 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EVS87_016905 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EVS87_016910 ENOG4105JFG SpoIID LytB domain protein EVS87_016920 ENOG4108KGH TRANSCRIPTIONal EVS87_016945 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EVS87_016950 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EVS87_016955 ENOG4105EY8 ABC transporter EVS87_016965 ENOG4107VDP teichoic acid biosynthesis EVS87_016970 ENOG4107SJB teichoic acid biosynthesis EVS87_016980 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase EVS87_016990 ENOG4107RZX Teichoic acid biosynthesis protein EVS87_017000 ENOG4105DG6 mannose-6-phosphate isomerase EVS87_017010 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component EVS87_017015 ENOG4108JP0 extracellular solute-binding protein family 1 EVS87_017020 ENOG4105WH1 Two component transcriptional regulator luxr family EVS87_017025 ENOG4105C2F Histidine kinase EVS87_017035 ENOG4105I4A GCN5-related N-acetyltransferase EVS87_017040 ENOG4108UHU Aldolase EVS87_017045 ENOG4105D7K pfkb domain protein EVS87_017050 ENOG4108M60 Transcriptional regulator EVS87_017055 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) EVS87_017060 ENOG4105CHR reductase EVS87_017075 ENOG4108NHD germination protein EVS87_017085 ENOG4107RGC Glycosyl transferase, family 2 EVS87_017090 ENOG4105C54 Major Facilitator superfamily EVS87_017095 ENOG4108KGH TRANSCRIPTIONal EVS87_017100 ENOG4105J7I hydrolase EVS87_017105 ENOG4105K4H Nlp p60 protein EVS87_017110 ENOG4105PNM synthesis protein EVS87_017120 ENOG4105N98 Capsule biosynthesis protein capB EVS87_017140 ENOG4105ETE Transcriptional regulator (LacI family EVS87_017145 ENOG4108RVA ribokinase EVS87_017150 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EVS87_017155 ENOG4105C2J ABC transporter EVS87_017160 ENOG4105CNN ABC, transporter EVS87_017165 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EVS87_017170 ENOG4107XC4 flavin reductase domain protein, FMN-binding EVS87_017175 ENOG4107RSM transcriptional regulator EVS87_017185 ENOG4107FQX Alpha-acetolactate decarboxylase EVS87_017195 ENOG4105CAH Chromate EVS87_017200 ENOG4105FGV Chromate EVS87_017205 ENOG4105C6Y Udp-glucose 6-dehydrogenase EVS87_017210 ENOG4105KBK Zinc finger, swim domain protein EVS87_017215 ENOG4105C0D helicase EVS87_017220 ENOG4105BZU Histidine kinase EVS87_017225 ENOG410667J hydrolase EVS87_017240 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) EVS87_017245 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) EVS87_017255 ENOG4105CGA flagellar basal-body rod protein FlgG EVS87_017265 ENOG4105DFF Rod shape-determining protein mreb EVS87_017270 ENOG4105MT0 Sporulation transcriptional regulator spoiiid EVS87_017275 ENOG4107MII Sugar-specific transcriptional regulator TrmB EVS87_017280 ENOG4105CZM Major Facilitator EVS87_017285 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EVS87_017290 ENOG41080V3 Major Facilitator superfamily EVS87_017295 ENOG4105EAB amino acid AbC transporter EVS87_017300 ENOG4105E5Q amino acid AbC transporter EVS87_017305 ENOG4105CDA abc transporter atp-binding protein EVS87_017310 ENOG4105BZU Histidine kinase EVS87_017320 ENOG4105FRN stage II sporulation protein EVS87_017325 ENOG4107TCE N-acetyltransferase EVS87_017370 ENOG4105WDJ 50S ribosomal protein L33 EVS87_017375 ENOG4105CKI cobalamin synthesis protein EVS87_017380 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) EVS87_017390 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) EVS87_017395 ENOG4105FCD Major Facilitator EVS87_017400 ENOG4108J2R molybdopterin oxidoreductase EVS87_017405 ENOG4108TF4 von Willebrand factor, type A EVS87_017420 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EVS87_017430 ENOG4106778 Protein of unknown function (DUF1146) EVS87_017440 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) EVS87_017445 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) EVS87_017450 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) EVS87_017455 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) EVS87_017475 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) EVS87_017485 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) EVS87_017490 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) EVS87_017495 ENOG4108UIC UPF0340 protein EVS87_017500 ENOG4108YZG isomerase EVS87_017505 ENOG4107WAU Protein tyrosine phosphatase EVS87_017515 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EVS87_017525 ENOG4108ZXQ stage ii sporulation protein r EVS87_017535 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EVS87_017540 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) EVS87_017550 ENOG4107TT2 Auxin Efflux Carrier EVS87_017555 ENOG4105C6K Malic enzyme EVS87_017560 ENOG4107104 thymidine kinase EVS87_017565 ENOG41082DI 50s ribosomal protein l31 EVS87_017570 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) EVS87_017575 ENOG4105CBT Fructose-1,6-bisphosphatase EVS87_017580 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) EVS87_017590 ENOG4105D2N Aldolase EVS87_017595 ENOG410812K response regulator receiver protein EVS87_017605 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) EVS87_017615 ENOG41081I9 integral membrane protein EVS87_017625 ENOG4105C1G acyl-Coa dehydrogenase EVS87_017630 ENOG4105C1G acyl-Coa dehydrogenase EVS87_017635 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EVS87_017645 ENOG4105DF6 Fe-S oxidoreductase EVS87_017665 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EVS87_017675 ENOG4105BZ1 (ABC) transporter EVS87_017680 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) EVS87_017695 ENOG4105C75 arginyL-tRNA synthetase EVS87_017700 ENOG410684U Domain of unknown function (DUF1934) EVS87_017710 ENOG4105CYW agmatinase EVS87_017715 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) EVS87_017720 ENOG4105BZ4 penicillin-binding protein EVS87_017725 ENOG4108XFG YwhD family EVS87_017730 ENOG4108Z4T Peptidase M50 EVS87_017735 ENOG41069HH 4-oxalocrotonate tautomerase EVS87_017750 ENOG4108KSA LysR family transcriptional regulator EVS87_017755 ENOG4108UZX fmn reductase EVS87_017760 ENOG4105DEN Luciferase family EVS87_017770 ENOG4108XSB acetyltransferase, (GNAT) family EVS87_017785 ENOG4105E5Q amino acid AbC transporter EVS87_017790 ENOG4105CDA abc transporter atp-binding protein EVS87_017800 ENOG4105DCI Phosphohydrolase EVS87_017805 ENOG4105QAT UPF0741 protein EVS87_017810 ENOG4108VCI transcription factor, rsfa family EVS87_017820 ENOG4107QZ7 Cellulose synthase catalytic subunit EVS87_017830 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) EVS87_017850 ENOG4107EV6 Inherit from COG: YD repeat protein EVS87_017880 ENOG4105JSC dimethylmenaquinone methyltransferase EVS87_017890 ENOG4108IJ2 phosphate acetyltransferase EVS87_017895 ENOG4107JTW chlorite dismutase EVS87_017900 ENOG4105F27 Major Facilitator EVS87_017910 ENOG4105FCW Major Facilitator superfamily EVS87_017915 ENOG41061WN bacilysin biosynthesis protein EVS87_017920 ENOG4106CHD Bacilysin biosynthesis protein bacB EVS87_017925 ENOG4105CHR reductase EVS87_017930 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase EVS87_017935 ENOG4105CHM Aminotransferase EVS87_017945 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase EVS87_017950 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase EVS87_017955 ENOG4105C1B dTDP-glucose 4-6-dehydratase EVS87_017960 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) EVS87_017965 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG EVS87_017970 ENOG4107TY6 Acylneuraminate cytidylyltransferase EVS87_017980 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD EVS87_017985 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EVS87_018030 ENOG4105C26 Dehydrogenase EVS87_018035 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) EVS87_018040 ENOG4108RJ9 Glycosyl transferase, family 2 EVS87_018050 ENOG4105DWF phosphomethylpyrimidine kinase EVS87_018070 ENOG4105C5Y PTS System EVS87_018085 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin EVS87_018095 ENOG4105DEN Luciferase family EVS87_018100 ENOG4108DBC nitroreductase EVS87_018115 ENOG41060D1 Quinol oxidase EVS87_018120 ENOG4105CCU oxidase (Subunit III) EVS87_018125 ENOG4105BZ9 Cytochrome C oxidase, subunit I EVS87_018130 ENOG4105E2S oxidase) subunit II EVS87_018145 ENOG4105CMR udp-glucose 4-epimerase EVS87_018150 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) EVS87_018165 ENOG4105WH5 Teichoic acid glycosylation protein EVS87_018200 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) EVS87_018205 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase EVS87_018210 ENOG4105CMU LysR family (Transcriptional regulator EVS87_018220 ENOG41067MG lrgb family EVS87_018225 ENOG4105DR4 Methyltransferase EVS87_018240 ENOG4105E5Q amino acid AbC transporter EVS87_018245 ENOG4107R0W ABC transporter EVS87_018265 ENOG4105CNN ABC, transporter EVS87_018270 ENOG4105C2J ABC transporter EVS87_018275 ENOG4108QGH periplasmic EVS87_018280 ENOG4108M26 parallel beta-helix repeat protein EVS87_018285 ENOG4105CM2 brancheD-chain amino acid aminotransferase EVS87_018300 ENOG4105F8D glycoside hydrolase family 4 EVS87_018305 ENOG4105VCP PTS System EVS87_018310 ENOG4105CK1 PTS System EVS87_018315 ENOG4105VZJ PTS System EVS87_018320 ENOG4105EMD TRANSCRIPTIONal EVS87_018335 ENOG4107R37 Glutamate dehydrogenase EVS87_018355 ENOG4108J20 pectate lyase EVS87_018360 ENOG4108JJ8 (ABC) transporter EVS87_018365 ENOG4108JJ9 ABC, transporter EVS87_018370 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EVS87_018375 ENOG4105C4M (Ubiquinol oxidase) subunit I EVS87_018385 ENOG4105DQ5 transport system permease protein EVS87_018390 ENOG4108HUF Transporter EVS87_018395 ENOG4105KFN sortase, SrtB family EVS87_018420 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) EVS87_018425 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) EVS87_018430 ENOG4105KVH Transcriptional regulator EVS87_018435 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase EVS87_018440 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) EVS87_018445 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EVS87_018450 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) EVS87_018455 ENOG4107BJW polysaccharide deacetylase EVS87_018460 ENOG4105VCP PTS System EVS87_018465 ENOG4105VZJ PTS System EVS87_018470 ENOG4105CS2 ec 3.2.1.21 EVS87_018475 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) EVS87_018480 ENOG4105CK1 PTS System EVS87_018485 ENOG4105EMD TRANSCRIPTIONal EVS87_018515 ENOG4108IJ0 Aspartate ammonia-lyase EVS87_018520 ENOG4105HDK L-asparaginase EVS87_018525 ENOG4108IMY Transcriptional regulator EVS87_018555 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) EVS87_018570 ENOG4106KNT transcriptional regulator EVS87_018575 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EVS87_018585 ENOG4105C6Z Gluconate EVS87_018600 ENOG4105C19 ABC transporter EVS87_018620 ENOG4105CS2 ec 3.2.1.21 EVS87_018625 ENOG4105C5Y PTS System EVS87_018630 ENOG4105CID antiterminator EVS87_018635 ENOG4108XI2 Domain of unknown function (DUF1963) EVS87_018645 ENOG4108W7F transporter, permease EVS87_018650 ENOG4108JJB ABC transporter EVS87_018655 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein EVS87_018660 ENOG4105ETU transcriptional activator (TenA EVS87_018685 ENOG4107G87 m6 family metalloprotease domain protein EVS87_018690 ENOG41067V3 Antibiotic biosynthesis monooxygenase EVS87_018695 ENOG4108TVJ Nitroreductase EVS87_018700 ENOG4105FS7 Transcriptional regulator EVS87_018705 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) EVS87_018710 ENOG4105D9N nucleoside EVS87_018715 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) EVS87_018720 ENOG4107RHR regulatoR EVS87_018730 ENOG4105EXC Acyl-transferase EVS87_018735 ENOG4105DXI Major Facilitator superfamily EVS87_018740 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EVS87_018745 ENOG4105HMZ Methyltransferase EVS87_018755 ENOG410667J hydrolase EVS87_018760 ENOG4105W1Y Transcriptional regulator EVS87_018765 ENOG4105EE0 oxidoreductase EVS87_018770 ENOG4105FKZ Methyl-accepting chemotaxis EVS87_018780 ENOG4105F1N DNA alkylation repair EVS87_018785 ENOG4105C6Z Gluconate EVS87_018790 ENOG4105CMG Carbohydrate kinase EVS87_018795 ENOG4106KNT transcriptional regulator EVS87_018835 ENOG4105DUM transcriptional regulator, lysR family EVS87_018845 ENOG4107FKK extracellular solute-binding protein family 1 EVS87_018855 ENOG4105EG2 ABC transporter, permease EVS87_018865 ENOG4105C4C beta-galactosidase EVS87_018870 ENOG4105D4T Citrate transporter EVS87_018880 ENOG4108TU7 Inherit from COG: (ABC) transporter EVS87_018885 ENOG4105CJ1 ABC, transporter EVS87_018890 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EVS87_018895 ENOG4105BZW Glycerate kinase EVS87_018900 ENOG4107QQ0 gntp family EVS87_018905 ENOG4107VHA regulatoR EVS87_018910 ENOG4105YA8 Transcriptional regulator EVS87_018915 ENOG4107Y80 Major Facilitator superfamily EVS87_018925 ENOG4105C19 ABC transporter EVS87_018940 ENOG4105CID antiterminator EVS87_018945 ENOG4105CS2 ec 3.2.1.21 EVS87_018950 ENOG4105C5Y PTS System EVS87_018975 ENOG4105M6F mutator MutT protein EVS87_018990 ENOG4105C85 amino acid EVS87_018995 ENOG4105ETE Transcriptional regulator (LacI family EVS87_019005 ENOG4105E2X shikimate dehydrogenase EVS87_019050 ENOG4105CS2 ec 3.2.1.21 EVS87_019060 ENOG4108S3Y transcriptional regulator EVS87_019070 ENOG4105JAB phenazine biosynthesis protein, phzf family EVS87_019075 ENOG41080UQ Transcriptional regulator EVS87_019110 ENOG4105BZU Histidine kinase EVS87_019120 ENOG4105EYF MMPL domain protein EVS87_019125 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EVS87_019150 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) EVS87_019155 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) EVS87_019165 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) EVS87_019175 ENOG4108V7D UPF0397 protein EVS87_019195 ENOG4105WQG acetyltransferase EVS87_019200 ENOG4105C0H protease EVS87_019205 ENOG4105Q2H domain protein EVS87_019220 ENOG4105BZU Histidine kinase EVS87_019225 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EVS87_019250 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EVS87_019265 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis EVS87_019270 ENOG4105ST3 Transcriptional regulator EVS87_019275 ENOG4106A3M Cytochrome p-450 EVS87_019280 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase EVS87_019285 ENOG4105CDU Replicative dna helicase EVS87_019290 ENOG4106K80 EVS87_019300 ENOG4105NIV Esterase EVS87_019305 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EVS87_019310 ENOG4105E4F Isochorismate synthase EVS87_019315 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EVS87_019320 ENOG4105WQI isochorismatase EVS87_019325 ENOG4105CEY Amp-dependent synthetase and ligase EVS87_019330 ENOG4105WQT MbtH domain protein EVS87_019335 ENOG410874W AraC family transcriptional regulator EVS87_019345 ENOG4108SA1 esterase EVS87_019355 ENOG4105DJ2 Major Facilitator Superfamily EVS87_019360 ENOG4105K9Q Binds to the 23S rRNA (By similarity) EVS87_019365 ENOG4105BZR domain protein EVS87_019370 ENOG4108XMW Membrane EVS87_019375 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase EVS87_019380 ENOG4108P49 AntiSigma factor EVS87_019385 ENOG4105JVQ RNA Polymerase EVS87_019400 ENOG4105CS1 NAD(P)H quinone oxidoreductase EVS87_019405 ENOG4105FBA Phospholipase Carboxylesterase EVS87_019410 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase EVS87_019415 ENOG4105E90 ABC transporter EVS87_019420 ENOG4108IJ8 ABC transporter EVS87_019425 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EVS87_019430 ENOG4108UUM single-stranded DNA-binding protein EVS87_019435 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) EVS87_019440 ENOG4105C3G gtp-binding protein EVS87_019445 ENOG4105VDK protein, conserved in bacteria EVS87_019465 ENOG4108ZDA Sporulation protein YyaC EVS87_019470 ENOG4105FA0 parb-like partition protein EVS87_019475 ENOG4107QJE Chromosome Partitioning Protein EVS87_019490 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) EVS87_019495 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) EVS87_019500 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) EVS87_019510 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins EVS87_019515 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) EVS87_019525 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) EVS87_019530 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EVS87_019535 ENOG410848D S4 domain protein YaaA EVS87_019540 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) EVS87_019550 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EVS87_019555 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EVS87_019590 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EVS87_019600 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EVS87_019605 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) EVS87_019610 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) EVS87_019615 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) EVS87_019620 ENOG4105FKZ Methyl-accepting chemotaxis EVS87_019630 ENOG4105ZMH deoxynucleoside kinase EVS87_019640 ENOG4105VRS hydrolase family 18 EVS87_019645 ENOG4105GTG Isochorismatase EVS87_019650 ENOG4108Z6B deaminase EVS87_019660 ENOG4105C6E dna polymerase iii EVS87_019665 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) EVS87_019670 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) EVS87_019680 ENOG41067KS pro-sigma K processing EVS87_019720 ENOG4105CDW Resistance protein EVS87_019725 ENOG4105CXN decarboxylase EVS87_019730 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) EVS87_019735 ENOG4105X0R protein from nitrogen regulatory protein P-II EVS87_019740 ENOG4105XVJ Protein of unknown function (DUF327) EVS87_019745 ENOG4105FA2 dna polymerase iii EVS87_019750 ENOG4105MA4 psp1 domain protein EVS87_019755 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) EVS87_019760 ENOG41060K3 Methyltransferase EVS87_019765 ENOG4105VC4 domain protein EVS87_019770 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EVS87_019775 ENOG4105KRN Transcriptional regulator, abrb family EVS87_019785 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) EVS87_019790 ENOG4105F8V Hydrolase, tatD family EVS87_019795 ENOG41069ER domain protein EVS87_019805 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) EVS87_019810 ENOG4105XFA sporulation peptidase YabG EVS87_019815 ENOG4105W42 Veg protein EVS87_019820 ENOG4105XEW small acid-soluble spore protein EVS87_019825 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EVS87_019830 ENOG4105DFT pur operon repressor EVS87_019835 ENOG4105KME endoribonuclease L-psp EVS87_019845 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EVS87_019850 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EVS87_019855 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) EVS87_019860 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) EVS87_019870 ENOG4108JA2 transcriptioN-repair coupling factor EVS87_019875 ENOG4108M14 stage v sporulation protein t EVS87_019885 ENOG4108IY2 MazG family EVS87_019890 ENOG41082I2 s4 domain protein EVS87_019895 ENOG4105VYY sporulation protein yabp EVS87_019910 ENOG41060GV RNA binding s1 domain protein EVS87_019940 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EVS87_019945 ENOG4108UGV hypoxanthine phosphoribosyltransferase EVS87_019950 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EVS87_019955 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) EVS87_019960 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) EVS87_019965 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase EVS87_019970 ENOG4105C6T cysteine synthase EVS87_019975 ENOG4105CRQ synthase (Component I) EVS87_019980 ENOG4105DDQ anthranilate synthase EVS87_019985 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 EVS87_019990 ENOG4105EEI dihydropteroate synthase EVS87_019995 ENOG4105KRF dihydroneopterin aldolase EVS87_020000 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EVS87_020010 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EVS87_020015 ENOG4105CRK lysyL-tRNA synthetase