locus-tag class description ID12_00010 ENOG4105N67 Proton-coupled thiamine transporter YuaJ ID12_00015 ENOG4105VRR gCN5-related N-acetyltransferase ID12_00025 ENOG4105CNI cell division protein FtsW ID12_00030 ENOG4105CNI cell division protein FtsW ID12_00035 ENOG4105DZ6 Band 7 protein ID12_00045 ENOG4106DF1 ID12_00050 ENOG4108JB8 alcohol dehydrogenase ID12_00055 ENOG4105C26 Dehydrogenase ID12_00060 ENOG4105TRT Transcriptional regulator ID12_00075 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase ID12_00100 ENOG41068G1 ID12_00130 ENOG410906S phage-like element pbsx protein xkdt ID12_00135 ENOG41066EA baseplate J family protein ID12_00140 ENOG4105MFU Protein of unknown function (DUF2634) ID12_00150 ENOG4105X7F ID12_00155 ENOG4108WZM domain protein ID12_00160 ENOG4108FKH Transglycosylase SLT domain ID12_00160 ENOG4108FKH Transglycosylase SLT domain ID12_00170 ENOG4105MTC XkdN-like protein ID12_00180 ENOG4105FR7 XkdM protein, phage-like element PBSX ID12_00185 ENOG4105PQS phage protein ID12_00200 ENOG41060SN ID12_00225 ENOG4108MDF Phage Portal Protein ID12_00230 ENOG4105IG6 Phage terminase, large subunit ID12_00250 ENOG4105QBX endodeoxyribonuclease RusA ID12_00290 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) ID12_00300 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ID12_00315 ENOG4105EE0 oxidoreductase ID12_00320 ENOG4108Z0Z intracellular protease Pfpi family ID12_00325 ENOG4105C8Q Methyl-accepting chemotaxis ID12_00330 ENOG4105C8Q Methyl-accepting chemotaxis ID12_00335 ENOG4105C8Q Methyl-accepting chemotaxis ID12_00340 ENOG4105C8Q Methyl-accepting chemotaxis ID12_00355 ENOG4105EA8 2-Nitropropane dioxygenase ID12_00360 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme ID12_00365 ENOG4105C37 (CBS) domain ID12_00380 ENOG4107PBV potassium channel ID12_00395 ENOG4107QYV phosphohexose isomerase ID12_00405 ENOG4107QW4 alcohol dehydrogenase ID12_00410 ENOG4105WG9 Conserved Protein ID12_00420 ENOG4105CHM Aminotransferase ID12_00425 ENOG4108ZB6 transcriptional regulator AsnC family ID12_00430 ENOG4108MUZ hydrolase ID12_00440 ENOG4105C87 Aminotransferase class I and II ID12_00445 ENOG4108HGU Histidine kinase ID12_00455 ENOG4105Y38 Kinase-associated protein B ID12_00470 ENOG4105BZ4 penicillin-binding protein ID12_00475 ENOG4105KIR Thiol-disulfide oxidoreductase dcc ID12_00490 ENOG4108MRH transcriptional regulatory protein ID12_00495 ENOG4105DIH basic membrane ID12_00500 ENOG4108JQ9 ABC transporter ID12_00505 ENOG4105UIB (ABC) transporter ID12_00530 ENOG4105D65 subunit l ID12_00535 ENOG4105HC0 Na H antiporter ID12_00540 ENOG4108ZE9 Monovalent cation H antiporter subunit C ID12_00545 ENOG4108JPZ Monovalent cation H antiporter subunit D ID12_00550 ENOG4105SC1 monovalent cation H antiporter subunit E ID12_00560 ENOG4105KJM monovalent cation h antiporter subunit g ID12_00565 ENOG4105KA0 thioesterase Superfamily protein ID12_00575 ENOG4105BZU Histidine kinase ID12_00600 ENOG4105D58 Diguanylate phosphodiesterase ID12_00605 ENOG4105DAP Nicotinate phosphoribosyltransferase ID12_00635 ENOG4105C02 permease ID12_00655 ENOG410904N short-chain dehydrogenase reductase ID12_00690 ENOG4108K8K Transcriptional regulator ID12_00695 ENOG4105DCF alanine dehydrogenase ID12_00710 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ID12_00720 ENOG41069ER domain protein ID12_00735 ENOG4105CEP NADH dehydrogenase ID12_00740 ENOG4105CAY ferredoxin--nadp reductase ID12_00755 ENOG4108YX9 iron--sulfur cluster insertion protein erpA ID12_00760 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) ID12_00765 ENOG4105ZKE UPF0349 protein ID12_00785 ENOG41083MR nifu domain-containing protein ID12_00790 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein ID12_00800 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) ID12_00805 ENOG4105D6E homoserine dehydrogenase ID12_00810 ENOG4105C5I Dehydrogenase ID12_00820 ENOG4108W5N phosphatidylglycerophosphatase a ID12_00825 ENOG4105D4U had-superfamily hydrolase, subfamily iia ID12_00835 ENOG4105MMD transcriptional regulator ID12_00840 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) ID12_00850 ENOG4105FAA peptidase M23 ID12_00865 ENOG4108YTE sporulation protein YunB ID12_00870 ENOG4105KZD Domain of unknown function (DUF1805) ID12_00875 ENOG4107R8B 5'-nucleotidase ID12_00880 ENOG4105I3N Conserved Protein ID12_00885 ENOG4105G9B Transcriptional regulator ID12_00890 ENOG4105F0F Oxalate decarboxylase ID12_00900 ENOG4105C5R Aminotransferase ID12_00905 ENOG4108K8S endonuclease I ID12_00920 ENOG4108IHU transport system permease protein ID12_00925 ENOG4105DQ5 transport system permease protein ID12_00930 ENOG4108MES Periplasmic binding protein ID12_00950 ENOG4108SWU Histidine kinase ID12_00955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ID12_00960 ENOG4105DHF Membrane ID12_00970 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) ID12_00990 ENOG4105DZR Type I site-specific deoxyribonuclease ID12_01000 ENOG4105DIW FeS assembly protein SUFB ID12_01005 ENOG4108UNV SUF system FeS assembly protein, NifU family ID12_01010 ENOG4105C9B Cysteine desulfurase ID12_01015 ENOG4105JRK feS assembly protein SufD ID12_01020 ENOG4105C3K feS assembly ATPase SufC ID12_01035 ENOG4105D01 (LipO)protein ID12_01040 ENOG4108UMI ABC transporter, permease ID12_01045 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ID12_01070 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) ID12_01075 ENOG41080E8 Transcriptional regulator, Spx MgsR family ID12_01080 ENOG4105C1G acyl-Coa dehydrogenase ID12_01085 ENOG4105CHU acetyl-coa acetyltransferase ID12_01115 ENOG4105E0A ABC, transporter ID12_01125 ENOG4105E1F short-chain dehydrogenase reductase ID12_01130 ENOG4105C0H protease ID12_01140 ENOG4105F3H Histidine kinase ID12_01150 ENOG41067SE Tetr family transcriptional regulator ID12_01155 ENOG4105C9Q fumarate hydratase class II ID12_01185 ENOG4105WH1 Two component transcriptional regulator luxr family ID12_01190 ENOG4105ENE Histidine kinase ID12_01205 ENOG41087YS Phage shock protein A ID12_01215 ENOG4108WBT adenosyltransferase ID12_01220 ENOG4105CHR reductase ID12_01225 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) ID12_01230 ENOG4107S2N Type III effector Hrp-dependent ID12_01235 ENOG4108JUA Transcriptional regulator ID12_01250 ENOG4105C0A alcohol dehydrogenase ID12_01255 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ID12_01260 ENOG4105E0A ABC, transporter ID12_01265 ENOG4105EHG Permease protein ID12_01270 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) ID12_01280 ENOG4105CTX dehydratase ID12_01285 ENOG4107QZW Altronate oxidoreductase ID12_01290 ENOG4107KJX Transcriptional regulator ID12_01295 ENOG4105D2H Uronic isomerase ID12_01305 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ID12_01310 ENOG4105E0A ABC, transporter ID12_01315 ENOG4105EHG Permease protein ID12_01320 ENOG4105DQ5 transport system permease protein ID12_01330 ENOG4105D5Q Arginine ornithine antiporter ID12_01345 ENOG4107K5X Membrane-bound metal-dependent hydrolase ID12_01350 ENOG4107QZ2 Sulfatase ID12_01355 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein ID12_01360 ENOG4105E0C molybdate abc transporter ID12_01370 ENOG4105EVU fructokinase ID12_01375 ENOG4107SUZ Sodium/hydrogen exchanger family ID12_01380 ENOG4105EN6 Membrane ID12_01390 ENOG4107ZQN disulfide bond ID12_01395 ENOG4105C59 p-type ATPase ID12_01400 ENOG4105DIK (ABC) transporter ID12_01405 ENOG4105CC5 ABC transporter ID12_01410 ENOG4105DSE periplasmic solute binding protein ID12_01415 ENOG4105IIP Membrane ID12_01420 ENOG4105W1N transcriptional regulator ID12_01435 ENOG4108IJ0 Aspartate ammonia-lyase ID12_01450 ENOG4105C59 p-type ATPase ID12_01455 ENOG410681U heavy metal transport detoxification protein ID12_01460 ENOG4105VPX protein, conserved in bacteria ID12_01470 ENOG4105BZU Histidine kinase ID12_01495 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) ID12_01500 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ID12_01510 ENOG4105XZU Preprotein translocase, subunit SecG ID12_01535 ENOG4105KVH Transcriptional regulator ID12_01540 ENOG4105R40 Glycine betaine carnitine choline ID12_01545 ENOG4108HQR Glycine betaine ID12_01550 ENOG4105E90 ABC transporter ID12_01555 ENOG4108IJ8 ABC transporter ID12_01560 ENOG4107HG4 Transcriptional regulator ID12_01565 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein ID12_01575 ENOG4108W0I acetyltransferase ID12_01605 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) ID12_01615 ENOG4105CP7 Triose-phosphate isomerase ID12_01620 ENOG4105BZA Phosphoglycerate kinase ID12_01625 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ID12_01640 ENOG4105C8Y Acetylornithine aminotransferase ID12_01645 ENOG4108JUB Transcriptional regulator ID12_01650 ENOG4105JXH GntR family transcriptional regulator ID12_01660 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ID12_01670 ENOG4107R73 Mate efflux family protein ID12_01675 ENOG4108JQ7 (ABC) transporter ID12_01680 ENOG4105C3U ABC transporter ID12_01685 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ID12_01690 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ID12_01695 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein ID12_01700 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ID12_01705 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family ID12_01710 ENOG4105D3Q Sugar transferase ID12_01725 ENOG4107QRS glycosyltransferase group 2 family protein ID12_01730 ENOG41068W6 Capsular polysaccharide biosynthesis protein ID12_01735 ENOG4108KMV Glycosyl transferase (Group 1 ID12_01740 ENOG4105K64 Glycosyl transferase, family 2 ID12_01745 ENOG4108PQP glycosyl transferase group 1 ID12_01755 ENOG4108QV3 biosynthesis protein ID12_01760 ENOG4105HTX biosynthesis protein ID12_01775 ENOG4108V5C ABC transporter ID12_01780 ENOG4105EHG Permease protein ID12_01785 ENOG4105DQ5 transport system permease protein ID12_01790 ENOG4108ZJ4 polysaccharide deacetylase ID12_01800 ENOG4108S9F abc transporter, atp-binding protein ID12_01815 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ID12_01820 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein ID12_01830 ENOG4108MES Periplasmic binding protein ID12_01850 ENOG4107R3N Filamentation induced by cAMP protein fic ID12_01865 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ID12_01870 ENOG4108URH decarboxylase ID12_01875 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain ID12_01880 ENOG4105CHH sulfate transporter ID12_01885 ENOG4108V2W Carbonate dehydratase ID12_01895 ENOG4105C5I Dehydrogenase ID12_01905 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase ID12_01910 ENOG4105KRI phosphocarrier protein (HPr ID12_01915 ENOG4105CIE May be required for sporulation (By similarity) ID12_01920 ENOG4105CHW UPF0052 protein ID12_01925 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) ID12_01930 ENOG4108Z4K mutator MutT protein ID12_01935 ENOG4105C3M thioredoxin reductase ID12_01950 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ID12_01955 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) ID12_01960 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ID12_01965 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) ID12_01970 ENOG4105ECC imidazole-glycerol-phosphate dehydratase ID12_01975 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ID12_01980 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) ID12_01985 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) ID12_02005 ENOG4108RYK Nad-dependent epimerase dehydratase ID12_02010 ENOG4108Z40 Transcriptional regulator ID12_02015 ENOG4108S4C acetyltransferase ID12_02020 ENOG4107XGZ Hydrolase ID12_02025 ENOG4105HKU nucleoside recognition domain-containing protein ID12_02035 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) ID12_02040 ENOG4105CE4 GlcNAc 6-P deacetylase ID12_02045 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) ID12_02050 ENOG4105FDP GntR family transcriptional regulator ID12_02055 ENOG41088CQ domain protein ID12_02060 ENOG41086DT Membrane protein of unknown function ID12_02065 ENOG41067S9 phage shock protein C, PspC ID12_02070 ENOG4108PY7 ID12_02085 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ID12_02090 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) ID12_02105 ENOG4105MKU Transcriptional regulator ID12_02120 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ID12_02125 ENOG4105BZU Histidine kinase ID12_02130 ENOG4105EDW glycosyl transferase, family 39 ID12_02135 ENOG4105CKK Glycosyl transferase, family 2 ID12_02145 ENOG4108RCM Nitroreductase ID12_02150 ENOG4105KVH Transcriptional regulator ID12_02165 ENOG4105CN1 protease ID12_02180 ENOG4105CRP Part of the ABC transporter FtsEX involved in ID12_02185 ENOG4105CAK Cell division ATP-binding protein ftsE ID12_02210 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) ID12_02220 ENOG4105MS2 ribosomal subunit Interface protein ID12_02225 ENOG4105C8Q Methyl-accepting chemotaxis ID12_02240 ENOG4105MQ3 flagellar protein FliS ID12_02245 ENOG4107RT6 flagellar hook-associated ID12_02250 ENOG41083S7 flagellar protein FlaG ID12_02255 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) ID12_02260 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) ID12_02265 ENOG4105MKD ID12_02270 ENOG4105DTJ flagellar hook-associated protein ID12_02275 ENOG4105E1Q flagellar hook-associated protein ID12_02290 ENOG4105RU3 ID12_02295 ENOG41081UC Inherit from COG: Competence protein ID12_02315 ENOG4105WH1 Two component transcriptional regulator luxr family ID12_02320 ENOG4105BZU Histidine kinase ID12_02325 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein ID12_02330 ENOG4108KGH TRANSCRIPTIONal ID12_02335 ENOG4105ESV Glycosyl transferase, family 4 ID12_02340 ENOG4107EF8 Glycosyl transferase (Group 1 ID12_02355 ENOG4105QZI O-Antigen Polymerase ID12_02360 ENOG4105C1B dTDP-glucose 4-6-dehydratase ID12_02365 ENOG4105C6Y Udp-glucose 6-dehydrogenase ID12_02370 ENOG4107RA4 Glycosyl transferase (Group 1 ID12_02375 ENOG4105PSV Polysaccharide Biosynthesis Protein ID12_02380 ENOG4105D3Q Sugar transferase ID12_02390 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ID12_02395 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ID12_02400 ENOG4105JFG SpoIID LytB domain protein ID12_02410 ENOG4108KGH TRANSCRIPTIONal ID12_02415 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase ID12_02420 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ID12_02425 ENOG4105EY8 ABC transporter ID12_02440 ENOG4107SJB teichoic acid biosynthesis ID12_02450 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase ID12_02460 ENOG4107RZX Teichoic acid biosynthesis protein ID12_02470 ENOG4105DG6 mannose-6-phosphate isomerase ID12_02480 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component ID12_02485 ENOG4108JP0 extracellular solute-binding protein family 1 ID12_02490 ENOG4105WH1 Two component transcriptional regulator luxr family ID12_02495 ENOG4105C2F Histidine kinase ID12_02505 ENOG4105I4A GCN5-related N-acetyltransferase ID12_02510 ENOG4108UHU Aldolase ID12_02515 ENOG4105D7K pfkb domain protein ID12_02520 ENOG4108M60 Transcriptional regulator ID12_02525 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) ID12_02530 ENOG4105CHR reductase ID12_02545 ENOG4108NHD germination protein ID12_02550 ENOG4107RGC Glycosyl transferase, family 2 ID12_02560 ENOG4105C54 Major Facilitator superfamily ID12_02565 ENOG4108KGH TRANSCRIPTIONal ID12_02570 ENOG4105J7I hydrolase ID12_02575 ENOG4105K4H Nlp p60 protein ID12_02585 ENOG4105PNM synthesis protein ID12_02595 ENOG4105N98 Capsule biosynthesis protein capB ID12_02615 ENOG4105ETE Transcriptional regulator (LacI family ID12_02620 ENOG4108RVA ribokinase ID12_02625 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) ID12_02630 ENOG4105C2J ABC transporter ID12_02635 ENOG4105CNN ABC, transporter ID12_02640 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ID12_02645 ENOG4107XC4 flavin reductase domain protein, FMN-binding ID12_02650 ENOG4107RSM transcriptional regulator ID12_02660 ENOG4107FQX Alpha-acetolactate decarboxylase ID12_02670 ENOG4105CAH Chromate ID12_02675 ENOG4105FGV Chromate ID12_02680 ENOG4105C6Y Udp-glucose 6-dehydrogenase ID12_02690 ENOG4105KBK Zinc finger, swim domain protein ID12_02695 ENOG4105C0D helicase ID12_02700 ENOG4105BZU Histidine kinase ID12_02705 ENOG410667J hydrolase ID12_02720 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) ID12_02725 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) ID12_02735 ENOG4105CGA flagellar basal-body rod protein FlgG ID12_02750 ENOG4105DFF Rod shape-determining protein mreb ID12_02755 ENOG4105MT0 Sporulation transcriptional regulator spoiiid ID12_02760 ENOG4107MII Sugar-specific transcriptional regulator TrmB ID12_02765 ENOG4105CZM Major Facilitator ID12_02770 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase ID12_02775 ENOG41080V3 Major Facilitator superfamily ID12_02780 ENOG4105EAB amino acid AbC transporter ID12_02785 ENOG4105E5Q amino acid AbC transporter ID12_02790 ENOG4105CDA abc transporter atp-binding protein ID12_02795 ENOG4105BZU Histidine kinase ID12_02805 ENOG4105FRN stage II sporulation protein ID12_02810 ENOG4107TCE N-acetyltransferase ID12_02845 ENOG4105WDJ 50S ribosomal protein L33 ID12_02850 ENOG4105CKI cobalamin synthesis protein ID12_02855 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ID12_02865 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ID12_02870 ENOG4105FCD Major Facilitator ID12_02875 ENOG4108J2R molybdopterin oxidoreductase ID12_02880 ENOG4108TF4 von Willebrand factor, type A ID12_02895 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ID12_02905 ENOG4106778 Protein of unknown function (DUF1146) ID12_02915 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) ID12_02920 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) ID12_02925 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) ID12_02930 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) ID12_02950 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) ID12_02965 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) ID12_02970 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ID12_02975 ENOG4108UIC UPF0340 protein ID12_02980 ENOG4108YZG isomerase ID12_02985 ENOG4107WAU Protein tyrosine phosphatase ID12_02995 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ID12_03005 ENOG4108ZXQ stage ii sporulation protein r ID12_03015 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ID12_03020 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) ID12_03030 ENOG4107TT2 Auxin Efflux Carrier ID12_03035 ENOG4105C6K Malic enzyme ID12_03040 ENOG4107104 thymidine kinase ID12_03045 ENOG41082DI 50s ribosomal protein l31 ID12_03050 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) ID12_03055 ENOG4105CBT Fructose-1,6-bisphosphatase ID12_03060 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ID12_03070 ENOG4105D2N Aldolase ID12_03075 ENOG410812K response regulator receiver protein ID12_03085 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) ID12_03095 ENOG41081I9 integral membrane protein ID12_03105 ENOG4105C1G acyl-Coa dehydrogenase ID12_03110 ENOG4105C1G acyl-Coa dehydrogenase ID12_03115 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ID12_03125 ENOG4105DF6 Fe-S oxidoreductase ID12_03145 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ID12_03155 ENOG4105BZ1 (ABC) transporter ID12_03160 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ID12_03175 ENOG4105C75 arginyL-tRNA synthetase ID12_03180 ENOG410684U Domain of unknown function (DUF1934) ID12_03190 ENOG4105CYW agmatinase ID12_03195 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) ID12_03200 ENOG4105BZ4 penicillin-binding protein ID12_03205 ENOG4108XFG YwhD family ID12_03210 ENOG4108Z4T Peptidase M50 ID12_03215 ENOG41069HH 4-oxalocrotonate tautomerase ID12_03230 ENOG4108KSA LysR family transcriptional regulator ID12_03235 ENOG4108UZX fmn reductase ID12_03240 ENOG4105DEN Luciferase family ID12_03250 ENOG4108XSB acetyltransferase, (GNAT) family ID12_03265 ENOG4105E5Q amino acid AbC transporter ID12_03270 ENOG4105CDA abc transporter atp-binding protein ID12_03280 ENOG4105DCI Phosphohydrolase ID12_03285 ENOG4105QAT UPF0741 protein ID12_03290 ENOG4108VCI transcription factor, rsfa family ID12_03300 ENOG4107QZ7 Cellulose synthase catalytic subunit ID12_03310 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) ID12_03375 ENOG4105JSC dimethylmenaquinone methyltransferase ID12_03385 ENOG4108IJ2 phosphate acetyltransferase ID12_03390 ENOG4107JTW chlorite dismutase ID12_03395 ENOG4105F27 Major Facilitator ID12_03405 ENOG4105FCW Major Facilitator superfamily ID12_03410 ENOG41061WN bacilysin biosynthesis protein ID12_03415 ENOG4106CHD Bacilysin biosynthesis protein bacB ID12_03420 ENOG4105CHR reductase ID12_03425 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase ID12_03430 ENOG4105CHM Aminotransferase ID12_03440 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase ID12_03445 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase ID12_03450 ENOG4105C1B dTDP-glucose 4-6-dehydratase ID12_03455 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) ID12_03460 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG ID12_03465 ENOG4107TY6 Acylneuraminate cytidylyltransferase ID12_03475 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD ID12_03480 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ID12_03525 ENOG4105C26 Dehydrogenase ID12_03530 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) ID12_03535 ENOG4108RJ9 Glycosyl transferase, family 2 ID12_03545 ENOG4105DWF phosphomethylpyrimidine kinase ID12_03565 ENOG4105C5Y PTS System ID12_03580 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin ID12_03590 ENOG4105DEN Luciferase family ID12_03595 ENOG4108DBC nitroreductase ID12_03610 ENOG41060D1 Quinol oxidase ID12_03615 ENOG4105CCU oxidase (Subunit III) ID12_03620 ENOG4105BZ9 Cytochrome C oxidase, subunit I ID12_03625 ENOG4105E2S oxidase) subunit II ID12_03640 ENOG4105CMR udp-glucose 4-epimerase ID12_03645 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) ID12_03660 ENOG4105WH5 Teichoic acid glycosylation protein ID12_03710 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) ID12_03715 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase ID12_03720 ENOG4105CMU LysR family (Transcriptional regulator ID12_03730 ENOG41067MG lrgb family ID12_03735 ENOG4105DR4 Methyltransferase ID12_03750 ENOG4105E5Q amino acid AbC transporter ID12_03755 ENOG4107R0W ABC transporter ID12_03780 ENOG4105CNN ABC, transporter ID12_03785 ENOG4105C2J ABC transporter ID12_03790 ENOG4108QGH periplasmic ID12_03795 ENOG4108M26 parallel beta-helix repeat protein ID12_03800 ENOG4105CM2 brancheD-chain amino acid aminotransferase ID12_03815 ENOG4105F8D glycoside hydrolase family 4 ID12_03820 ENOG4105VCP PTS System ID12_03825 ENOG4105CK1 PTS System ID12_03830 ENOG4105VZJ PTS System ID12_03835 ENOG4105EMD TRANSCRIPTIONal ID12_03855 ENOG4107R37 Glutamate dehydrogenase ID12_03875 ENOG4108J20 pectate lyase ID12_03880 ENOG4108JJ8 (ABC) transporter ID12_03885 ENOG4108JJ9 ABC, transporter ID12_03890 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ID12_03895 ENOG4105C4M (Ubiquinol oxidase) subunit I ID12_03900 ENOG4105E0A ABC, transporter ID12_03905 ENOG4105DQ5 transport system permease protein ID12_03910 ENOG4108HUF Transporter ID12_03915 ENOG4105KFN sortase, SrtB family ID12_03940 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) ID12_03945 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) ID12_03955 ENOG4105KVH Transcriptional regulator ID12_03960 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase ID12_03965 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ID12_03970 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ID12_03975 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) ID12_03985 ENOG4107BJW polysaccharide deacetylase ID12_03990 ENOG4105VCP PTS System ID12_03995 ENOG4105VZJ PTS System ID12_04000 ENOG4105CS2 ec 3.2.1.21 ID12_04005 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) ID12_04015 ENOG4105CK1 PTS System ID12_04020 ENOG4105EMD TRANSCRIPTIONal ID12_04045 ENOG4105DFD Na H antiporter ID12_04050 ENOG4108IJ0 Aspartate ammonia-lyase ID12_04055 ENOG4105HDK L-asparaginase ID12_04060 ENOG4108IMY Transcriptional regulator ID12_04090 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) ID12_04105 ENOG4106KNT transcriptional regulator ID12_04110 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ID12_04120 ENOG4105C6Z Gluconate ID12_04135 ENOG4105C19 ABC transporter ID12_04140 ENOG4105CS2 ec 3.2.1.21 ID12_04145 ENOG4105C5Y PTS System ID12_04150 ENOG4105CID antiterminator ID12_04155 ENOG4108XI2 Domain of unknown function (DUF1963) ID12_04165 ENOG4108W7F transporter, permease ID12_04170 ENOG4108JJB ABC transporter ID12_04175 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein ID12_04180 ENOG4105ETU transcriptional activator (TenA ID12_04210 ENOG4107G87 m6 family metalloprotease domain protein ID12_04215 ENOG41067V3 Antibiotic biosynthesis monooxygenase ID12_04220 ENOG4108TVJ Nitroreductase ID12_04225 ENOG4105FS7 Transcriptional regulator ID12_04235 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) ID12_04240 ENOG4105D9N nucleoside ID12_04245 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) ID12_04250 ENOG4107RHR regulatoR ID12_04260 ENOG4105EXC Acyl-transferase ID12_04265 ENOG4105DXI Major Facilitator superfamily ID12_04275 ENOG4105HMZ Methyltransferase ID12_04285 ENOG410667J hydrolase ID12_04290 ENOG4105W1Y Transcriptional regulator ID12_04295 ENOG4105EE0 oxidoreductase ID12_04300 ENOG4105FKZ Methyl-accepting chemotaxis ID12_04315 ENOG4105F1N DNA alkylation repair ID12_04320 ENOG4105C6Z Gluconate ID12_04325 ENOG4105CMG Carbohydrate kinase ID12_04330 ENOG4106KNT transcriptional regulator ID12_04370 ENOG4105DUM transcriptional regulator, lysR family ID12_04380 ENOG4107FKK extracellular solute-binding protein family 1 ID12_04390 ENOG4105EG2 ABC transporter, permease ID12_04400 ENOG4105C4C beta-galactosidase ID12_04405 ENOG4105D4T Citrate transporter ID12_04415 ENOG4108TU7 Inherit from COG: (ABC) transporter ID12_04420 ENOG4105CJ1 ABC, transporter ID12_04425 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA ID12_04430 ENOG4105BZW Glycerate kinase ID12_04435 ENOG4107QQ0 gntp family ID12_04440 ENOG4107VHA regulatoR ID12_04445 ENOG4105YA8 Transcriptional regulator ID12_04450 ENOG4107Y80 Major Facilitator superfamily ID12_04460 ENOG4105C19 ABC transporter ID12_04470 ENOG410780I phosphoprotein phosphatase activity ID12_04475 ENOG4105CID antiterminator ID12_04480 ENOG4105CS2 ec 3.2.1.21 ID12_04485 ENOG4105C5Y PTS System ID12_04510 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) ID12_04525 ENOG4105C85 amino acid ID12_04530 ENOG4105ETE Transcriptional regulator (LacI family ID12_04540 ENOG4105E2X shikimate dehydrogenase ID12_04585 ENOG4105CS2 ec 3.2.1.21 ID12_04590 ENOG4105C5Y PTS System ID12_04595 ENOG4108S3Y transcriptional regulator ID12_04610 ENOG4105JAB phenazine biosynthesis protein, phzf family ID12_04615 ENOG41080UQ Transcriptional regulator ID12_04635 ENOG4105DS0 Transcriptional regulator, Crp Fnr family ID12_04675 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) ID12_04685 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) ID12_04695 ENOG4108V7D UPF0397 protein ID12_04715 ENOG4105WQG acetyltransferase ID12_04720 ENOG4105C0H protease ID12_04725 ENOG4105Q2H domain protein ID12_04740 ENOG4105BZU Histidine kinase ID12_04745 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ID12_04770 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ID12_04785 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis ID12_04790 ENOG4105ST3 Transcriptional regulator ID12_04795 ENOG4106A3M Cytochrome p-450 ID12_04800 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase ID12_04805 ENOG4105CDU Replicative dna helicase ID12_04810 ENOG4106K80 ID12_04825 ENOG4105NIV Esterase ID12_04830 ENOG410874W AraC family transcriptional regulator ID12_04840 ENOG4108SA1 esterase ID12_04850 ENOG4105DJ2 Major Facilitator Superfamily ID12_04855 ENOG4105K9Q Binds to the 23S rRNA (By similarity) ID12_04860 ENOG4105BZR domain protein ID12_04865 ENOG4108XMW Membrane ID12_04870 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase ID12_04875 ENOG4108P49 AntiSigma factor ID12_04880 ENOG4105JVQ RNA Polymerase ID12_04890 ENOG4105CH6 catalase ID12_04895 ENOG4105CS1 NAD(P)H quinone oxidoreductase ID12_04900 ENOG4105FBA Phospholipase Carboxylesterase ID12_04905 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase ID12_04910 ENOG4105E90 ABC transporter ID12_04915 ENOG4108IJ8 ABC transporter ID12_04920 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) ID12_04925 ENOG4108UUM single-stranded DNA-binding protein ID12_04930 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) ID12_04935 ENOG4105C3G gtp-binding protein ID12_04940 ENOG4105VDK protein, conserved in bacteria ID12_04960 ENOG4108ZDA Sporulation protein YyaC ID12_04965 ENOG4105FA0 parb-like partition protein ID12_04970 ENOG4107QJE Chromosome Partitioning Protein ID12_04985 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) ID12_04990 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) ID12_04995 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) ID12_05005 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins ID12_05010 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) ID12_05020 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) ID12_05025 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ID12_05030 ENOG410848D S4 domain protein YaaA ID12_05035 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) ID12_05045 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ID12_05050 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ID12_05090 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ID12_05100 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ID12_05105 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) ID12_05110 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) ID12_05115 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) ID12_05120 ENOG4105FKZ Methyl-accepting chemotaxis ID12_05130 ENOG4105ZMH deoxynucleoside kinase ID12_05140 ENOG4105VRS hydrolase family 18 ID12_05145 ENOG4105GTG Isochorismatase ID12_05150 ENOG4108Z6B deaminase ID12_05155 ENOG4105C6E dna polymerase iii ID12_05160 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) ID12_05165 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) ID12_05175 ENOG41067KS pro-sigma K processing ID12_05215 ENOG4105CDW Resistance protein ID12_05220 ENOG4105CXN decarboxylase ID12_05225 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) ID12_05230 ENOG4105X0R protein from nitrogen regulatory protein P-II ID12_05235 ENOG4105XVJ Protein of unknown function (DUF327) ID12_05240 ENOG4105FA2 dna polymerase iii ID12_05245 ENOG4105MA4 psp1 domain protein ID12_05250 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) ID12_05255 ENOG41060K3 Methyltransferase ID12_05260 ENOG4105VC4 domain protein ID12_05265 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) ID12_05270 ENOG4105KRN Transcriptional regulator, abrb family ID12_05275 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) ID12_05280 ENOG4105F8V Hydrolase, tatD family ID12_05285 ENOG41069ER domain protein ID12_05295 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ID12_05300 ENOG4105XFA sporulation peptidase YabG ID12_05305 ENOG4105W42 Veg protein ID12_05310 ENOG4105XEW small acid-soluble spore protein ID12_05315 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) ID12_05320 ENOG4105DFT pur operon repressor ID12_05325 ENOG4105KME endoribonuclease L-psp ID12_05335 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ID12_05340 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ID12_05345 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) ID12_05350 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) ID12_05360 ENOG4108JA2 transcriptioN-repair coupling factor ID12_05365 ENOG4108M14 stage v sporulation protein t ID12_05375 ENOG4108IY2 MazG family ID12_05380 ENOG41082I2 s4 domain protein ID12_05385 ENOG4105VYY sporulation protein yabp ID12_05400 ENOG41060GV RNA binding s1 domain protein ID12_05435 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ID12_05440 ENOG4108UGV hypoxanthine phosphoribosyltransferase ID12_05445 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ID12_05450 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) ID12_05455 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) ID12_05460 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase ID12_05465 ENOG4105C6T cysteine synthase ID12_05470 ENOG4105CRQ synthase (Component I) ID12_05475 ENOG4105DDQ anthranilate synthase ID12_05480 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 ID12_05485 ENOG4105EEI dihydropteroate synthase ID12_05490 ENOG4105KRF dihydroneopterin aldolase ID12_05495 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ID12_05505 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ID12_05510 ENOG4105CRK lysyL-tRNA synthetase ID12_05595 ENOG4108Z0C Uvrb UvrC protein ID12_05600 ENOG41066A3 ATP guanido phosphotransferase ID12_05610 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ID12_05615 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) ID12_05620 ENOG4105CTP PilT protein domain protein ID12_05625 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) ID12_05630 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) ID12_05635 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) ID12_05640 ENOG4105D7W serine acetyltransferase ID12_05645 ENOG4105C8N cysteinyl-tRNA synthetase ID12_05650 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) ID12_05655 ENOG4105C2N RNA methyltransferase TrmH family group 3 ID12_05660 ENOG4105M0M Tetracycline resistance protein ID12_05675 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) ID12_05680 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) ID12_05685 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) ID12_05690 ENOG4108VZM 50s ribosomal protein L10 ID12_05695 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) ID12_05700 ENOG4107Y49 methyltransferase ID12_05705 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ID12_05710 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ID12_05715 ENOG4105XPM ribosomal protein ID12_05720 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) ID12_05725 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) ID12_05730 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ID12_05740 ENOG4107SKW Inherit from COG: Alpha beta hydrolase ID12_05745 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) ID12_05750 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) ID12_05755 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) ID12_05760 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) ID12_05765 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity ID12_05770 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ID12_05775 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) ID12_05780 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ID12_05785 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) ID12_05790 ENOG41082SA 50s ribosomal protein l29 ID12_05795 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal ID12_05800 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) ID12_05805 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) ID12_05810 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits ID12_05815 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ID12_05820 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) ID12_05825 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) ID12_05830 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ID12_05835 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ID12_05840 ENOG4105VPB 50S ribosomal protein L30 ID12_05845 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) ID12_05850 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ID12_05855 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) ID12_05860 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ID12_05865 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ID12_05875 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits ID12_05880 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) ID12_05885 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ID12_05890 ENOG4108ZT0 50S ribosomal protein l17 ID12_05895 ENOG4108JJB ABC transporter ID12_05900 ENOG4108JJB ABC transporter ID12_05905 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) ID12_05910 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) ID12_05915 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) ID12_05920 ENOG4108UJD 30S ribosomal protein S9 ID12_05955 ENOG4105D1F ATP-binding protein ID12_05970 ENOG4108NMV polysaccharide deacetylase ID12_06000 ENOG4105CHH sulfate transporter ID12_06010 ENOG4105EHZ conserved protein UCP016719 ID12_06015 ENOG4105D17 glycoside hydrolase, family 3 domain protein ID12_06035 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate ID12_06070 ENOG4105EMN RNA polymerase sigma factor ID12_06080 ENOG4105C8B TIGR00159 family ID12_06085 ENOG4107U5W ybbr family ID12_06090 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) ID12_06095 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ID12_06115 ENOG4105DA5 (ABC) transporter ID12_06125 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ID12_06155 ENOG410905X membrane-flanked domain protein ID12_06230 ENOG4105VZ8 Transcriptional regulator ID12_06240 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) ID12_06250 ENOG4105YA8 Transcriptional regulator ID12_06275 ENOG4107VXM glycerophosphoryl diester phosphodiesterase ID12_06280 ENOG4105CXY transporter ID12_06290 ENOG4105C7Z Conserved Protein ID12_06295 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ID12_06310 ENOG4105WAB arsR family transcriptional regulator ID12_06325 ENOG4105XTG Pfam:DUF156 ID12_06330 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase ID12_06340 ENOG4105VFE sira family ID12_06345 ENOG4107TPS domain protein ID12_06350 ENOG4105VFE sira family ID12_06355 ENOG41087NI Sulfite exporter TauE/SafE ID12_06365 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) ID12_06370 ENOG4108SUT Major Facilitator Superfamily ID12_06395 ENOG4105EWC Purine nucleoside phosphorylase ID12_06405 ENOG4107SCQ Iron-containing alcohol dehydrogenase ID12_06410 ENOG4105C72 UPF0176 protein ID12_06415 ENOG4107QTZ amino acid ID12_06425 ENOG4105CID antiterminator ID12_06430 ENOG4105C5Y PTS System ID12_06435 ENOG4105CS2 ec 3.2.1.21 ID12_06450 ENOG4105EMD TRANSCRIPTIONal ID12_06455 ENOG4105EVU fructokinase ID12_06460 ENOG4105C8I hydrolase, family 38 ID12_06465 ENOG4105DM4 PTS System ID12_06470 ENOG4108YRF PTS System ID12_06475 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein ID12_06480 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin ID12_06495 ENOG4108IQI permease ID12_06500 ENOG4108J5H Homocysteine s-methyltransferase ID12_06505 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) ID12_06525 ENOG4105C2C drug resistance transporter, Bcr CflA ID12_06545 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin ID12_06555 ENOG4105J7D transcriptional regulator ID12_06565 ENOG4105E2A Dehydrogenase ID12_06570 ENOG41067TZ transcriptional regulator, MarR family ID12_06580 ENOG4105CUB amino acid ID12_06590 ENOG4105D74 hydrolase ID12_06600 ENOG4105CSV Glutaminase ID12_06615 ENOG41060AI SEC-C motif ID12_06625 ENOG4107SET aldo keto reductase ID12_06635 ENOG4107Y7X LytTR ID12_06640 ENOG4108IUW ABC transporter ID12_06645 ENOG4108SDH ABC, transporter ID12_06670 ENOG4105H9W Short-chain dehydrogenase reductase Sdr ID12_06680 ENOG4105DEN Luciferase family ID12_06685 ENOG4108N0M stress protein ID12_06690 ENOG4106FN3 tellurium resistance protein ID12_06695 ENOG4106FN3 tellurium resistance protein ID12_06700 ENOG4107TS3 membrane protein, TerC ID12_06725 ENOG4108TTB tellurium resistance protein ID12_06735 ENOG4108IJ7 Glycine betaine ID12_06740 ENOG4107SQ8 Glycine betaine ID12_06770 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) ID12_06790 ENOG4105TRI Hydrolase ID12_06835 ENOG4105EIG urea carboxylase-associated protein 1 ID12_06840 ENOG4107RMH nh(3)-dependent nad( ) synthetase ID12_06875 ENOG4105FF2 Type I DHQase ID12_06880 ENOG4105C7K acetolactate synthase ID12_06890 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F ID12_06895 ENOG4105DJB Major Facilitator Superfamily ID12_06905 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region ID12_06910 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ID12_06915 ENOG41089UC methyltransferase, type 11 ID12_06920 ENOG4105C5Q Transcriptional regulator ID12_06925 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase ID12_06930 ENOG4105I82 acetyl xylan esterase ID12_06940 ENOG410756H nucleotidyltransferase ID12_06950 ENOG4105C26 Dehydrogenase ID12_06955 ENOG4107YHD transcriptional regulator ID12_06960 ENOG4107R5R arsenical pump membrane protein ID12_06965 ENOG4105E5Q amino acid AbC transporter ID12_06970 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein ID12_06980 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein ID12_06990 ENOG4108AQF aminoglycoside N(3)-acetyltransferase ID12_07000 ENOG4105C8Q Methyl-accepting chemotaxis ID12_07030 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ID12_07035 ENOG4105F38 ABC transporter, permease ID12_07045 ENOG4105CEY Amp-dependent synthetase and ligase ID12_07085 ENOG4108IUW ABC transporter ID12_07100 ENOG4105SX7 Transporter ID12_07115 ENOG41086D8 Transcriptional regulator ID12_07130 ENOG4105CDA abc transporter atp-binding protein ID12_07135 ENOG4105DRP amino acid AbC transporter ID12_07150 ENOG4108IQI permease ID12_07155 ENOG4105DUX Transporter ID12_07165 ENOG4105CPU Monooxygenase ID12_07170 ENOG4108XSB acetyltransferase, (GNAT) family ID12_07175 ENOG4105EAB amino acid AbC transporter ID12_07180 ENOG4108HW4 amino acid AbC transporter ID12_07190 ENOG4105CH2 amidohydrolase ID12_07195 ENOG4108PGP mmge prpd family protein ID12_07200 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ID12_07205 ENOG4105BZU Histidine kinase ID12_07215 ENOG4105CFH Aspartokinase ID12_07225 ENOG4105R8C Transcriptional regulator ID12_07235 ENOG4105YVS arsR family transcriptional regulator ID12_07245 ENOG4105EGI Transcriptional regulator ID12_07255 ENOG4108JPW Aminotransferase ID12_07260 ENOG4107QTZ amino acid ID12_07265 ENOG4105C26 Dehydrogenase ID12_07270 ENOG4105DYS nad(p)h dehydrogenase (quinone) ID12_07275 ENOG4105KTB nuclear export factor GLE1 ID12_07280 ENOG4108T5E Copper resistance protein ID12_07295 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase ID12_07300 ENOG4105C8Q Methyl-accepting chemotaxis ID12_07340 ENOG4105X3H Excalibur domain protein ID12_07350 ENOG4105E7W lamb ycsf family protein ID12_07355 ENOG4105C5A transporter ID12_07360 ENOG4105CFM UPF0317 protein ID12_07365 ENOG4105P4J Allophanate hydrolase, subunit 1 ID12_07375 ENOG4107258 Transcriptional regulator ID12_07380 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) ID12_07390 ENOG4105XJB lipolytic protein G-D-S-L family ID12_07400 ENOG4105ETD TRANSCRIPTIONal ID12_07405 ENOG4105HMZ Methyltransferase ID12_07410 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ID12_07420 ENOG410606W general stress protein ID12_07440 ENOG4105VCH membrane ID12_07445 ENOG4105DRR Transcriptional regulator, GntR family ID12_07460 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ID12_07465 ENOG4105C9U ATP-dependent DNA helicase RecQ ID12_07480 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) ID12_07485 ENOG4107R8N Glycosyl transferase, family 2 ID12_07495 ENOG4105C0X amino acid ID12_07550 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) ID12_07555 ENOG4107BMA Transglycosylase associated protein ID12_07560 ENOG4105EU9 ID12_07565 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit ID12_07570 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ID12_07575 ENOG4108MRH transcriptional regulatory protein ID12_07580 ENOG4107QJT sodium dicarboxylate symporter ID12_07585 ENOG4106F5Q Membrane ID12_07595 ENOG4105CJ1 ABC, transporter ID12_07615 ENOG4105SZ6 Thioredoxin ID12_07620 ENOG4105CPF Cell wall formation (By similarity) ID12_07625 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) ID12_07640 ENOG4105C1J atp-dependent rna helicase ID12_07645 ENOG410905X membrane-flanked domain protein ID12_07650 ENOG4105CKV Membrane ID12_07665 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein ID12_07670 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ID12_07680 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) ID12_07685 ENOG4107MMM Anti-sigma-factor antagonist ID12_07690 ENOG4105FUA antagonist ID12_07695 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase ID12_07700 ENOG4107SGM protein serine threonine phosphatase ID12_07705 ENOG4105WN5 stage II sporulation protein ID12_07710 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) ID12_07720 ENOG41064BQ Phosphatase ID12_07775 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase ID12_07800 ENOG4105VEQ Cold shock protein ID12_07805 ENOG4108VJ1 Transcriptional regulator (CarD family ID12_07810 ENOG4105DQ4 alcohol dehydrogenase ID12_07815 ENOG4105VUF Transcriptional regulator ID12_07830 ENOG4105C0R drug resistance transporter emrb qaca subfamily ID12_07850 ENOG4107GJV short-chain dehydrogenase reductase ID12_07860 ENOG4107RB3 L-asparaginase ID12_07910 ENOG4105VDT -acetyltransferase ID12_07915 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase ID12_07925 ENOG4105ST3 Transcriptional regulator ID12_07930 ENOG4105NAE bifunctional deaminase-reductase domain protein ID12_07935 ENOG41090MY MarR family Transcriptional regulator ID12_07940 ENOG4108TVJ Nitroreductase ID12_07960 ENOG4108JCI Transcriptional regulator ID12_07965 ENOG4108VP3 Lysine exporter protein (LysE YggA) ID12_07970 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) ID12_07980 ENOG4107ZBN O-methyltransferase ID12_07990 ENOG4108UMN azlc family ID12_08050 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) ID12_08055 ENOG4105K8N protein family UPF0079, ATPase ID12_08060 ENOG41072GX Peptidase M22 Glycoprotease ID12_08065 ENOG410801F ribosomal-protein-alanine acetyltransferase ID12_08070 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ID12_08075 ENOG4105C5H ABC transporter ID12_08080 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ID12_08085 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) ID12_08090 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) ID12_08095 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) ID12_08110 ENOG4108TYN CAAX amino terminal protease family protein ID12_08115 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) ID12_08120 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ID12_08125 ENOG4108U05 Transcriptional regulator ID12_08135 ENOG4108VXD carboxy-peptidase ID12_08175 ENOG4107STQ Multicopper oxidase ID12_08180 ENOG4105C85 amino acid ID12_08190 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ID12_08205 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) ID12_08220 ENOG4105KNA -acetyltransferase ID12_08235 ENOG4105JVQ RNA Polymerase ID12_08245 ENOG4108RWP Major Facilitator Superfamily protein ID12_08250 ENOG4105GZI Transcriptional regulator ID12_08255 ENOG4105C7N Xanthine uracil vitamin C permease ID12_08275 ENOG4108U5N UPF0316 protein ID12_08285 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ID12_08290 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit ID12_08295 ENOG4105C83 adenylosuccinate lyase ID12_08300 ENOG4105C8V SAICAR synthetase ID12_08305 ENOG4105VR9 phosphoribosylformylglycinamidine synthase ID12_08315 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii ID12_08325 ENOG4105CXB phosphoribosylaminoimidazole synthetase ID12_08330 ENOG4108V3E phosphoribosylglycinamide formyltransferase ID12_08335 ENOG4105DC1 bifunctional purine biosynthesis protein purh ID12_08340 ENOG4105C12 Phosphoribosylglycinamide synthetase ID12_08360 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ID12_08375 ENOG4107S4Y M20 DapE family protein YgeY ID12_08390 ENOG4105KGF protein, YerC YecD ID12_08400 ENOG4105CBC glutamate synthase ID12_08415 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) ID12_08420 ENOG4105C4R Atp-dependent dna helicase ID12_08425 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ID12_08440 ENOG4105CRN Aminoglycoside phosphotransferase ID12_08445 ENOG4105KT7 mgtC SapB transporter ID12_08450 ENOG4105CK7 Sodium proline symporter ID12_08455 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ID12_08460 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ID12_08465 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ID12_08470 ENOG4108IG5 Transcriptional regulator ID12_08480 ENOG4105DU0 nucleoside hydrolase ID12_08485 ENOG4105CBD Diacylglycerol kinase ID12_08490 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ID12_08495 ENOG4108JJB ABC transporter ID12_08520 ENOG41062ES Transcriptional regulator ID12_08525 ENOG4105C3M thioredoxin reductase ID12_08540 ENOG4105F8D glycoside hydrolase family 4 ID12_08545 ENOG4105HX0 Transcriptional regulator ID12_08570 ENOG4108R1P ID12_08580 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase ID12_08590 ENOG41090R9 glycosyltransferase ID12_08595 ENOG4107R51 Glycosyl transferase, family 2 ID12_08600 ENOG41090R9 glycosyltransferase ID12_08605 ENOG4105EU0 Major facilitator Superfamily ID12_08615 ENOG4107RVG penicillin-binding protein ID12_08620 ENOG4105C8P )-transporter ID12_08650 ENOG4105CUB amino acid ID12_08655 ENOG4107TVC Glycosyl transferase, family 2 ID12_08660 ENOG4105C5H ABC transporter ID12_08665 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) ID12_08670 ENOG4107SWG transcriptional regulator MERR family ID12_08675 ENOG4105DXB Major Facilitator superfamily ID12_08680 ENOG4105C5H ABC transporter ID12_08685 ENOG4105FDU atp-dependent rna helicase ID12_08690 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein ID12_08715 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ID12_08720 ENOG4105E6M Sulphatase-modifying factor protein ID12_08730 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ID12_08745 ENOG4108MRH transcriptional regulatory protein ID12_08770 ENOG4105PY6 Phenolic acid decarboxylase ID12_08775 ENOG4105U3E Transcriptional regulator ID12_08790 ENOG41084AG Acylphosphatase ID12_08795 ENOG4108RPX mosc domain containing protein ID12_08810 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) ID12_08820 ENOG4105NX3 Membrane ID12_08840 ENOG4105DY8 decarboxylase ID12_08845 ENOG4105C8Q Methyl-accepting chemotaxis ID12_08855 ENOG4105C5Y PTS System ID12_08860 ENOG4105CG3 alpha amylase, catalytic region ID12_08865 ENOG4107414 GntR family transcriptional regulator ID12_08875 ENOG4105CGH 5'-nucleotidase ID12_08880 ENOG4107RKG DJ-1/PfpI family ID12_08890 ENOG4105BZG amino acid carrier protein ID12_08895 ENOG4105KJF protein tyrosine phosphatase ID12_08905 ENOG4107U9T Pfam:Ribonuclease_BN ID12_08915 ENOG4108ISG Major Facilitator ID12_08925 ENOG4105UPD Calcium Proton ID12_08935 ENOG4105CDY transcriptional regulatory protein ID12_08945 ENOG4105D8X mechanosensitive ion channel ID12_08970 ENOG4105D7N magnesium and cobalt transport protein CorA ID12_08985 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ID12_09020 ENOG4107TXC Transcriptional regulator ID12_09025 ENOG4108RWP Major Facilitator Superfamily protein ID12_09040 ENOG4105C22 threonyL-tRNA synthetase ID12_09105 ENOG410839T multidrug resistance protein ID12_09125 ENOG4107TDE lipolytic protein G-D-S-L family ID12_09140 ENOG4108HUF Transporter ID12_09145 ENOG4105BZ1 (ABC) transporter ID12_09150 ENOG4105KK4 UPF0060 membrane protein ID12_09155 ENOG4105K6V RNA polymerase ID12_09180 ENOG4108YYS metal-dependent hydrolase (By similarity) ID12_09190 ENOG410834F Transcriptional regulator ID12_09215 ENOG4107Y03 Nitroreductase ID12_09230 ENOG4105ECP epimerase ID12_09235 ENOG4105KC9 Modulates RecA activity (By similarity) ID12_09260 ENOG4105CKK Glycosyl transferase, family 2 ID12_09265 ENOG4105EJV Membrane ID12_09270 ENOG4105MSY salicylate hydroxylase ID12_09285 ENOG4105F0F Oxalate decarboxylase ID12_09295 ENOG4106DF4 Sigma-70, region 4 ID12_09305 ENOG41067AE Membrane-bound metal-dependent hydrolase ID12_09310 ENOG4105CEN a g-specific adenine glycosylase ID12_09315 ENOG4106BXE ID12_09320 ENOG4105CAN Short-chain dehydrogenase reductase Sdr ID12_09335 ENOG4105EVI UPF0374 protein ID12_09340 ENOG4105BZ1 (ABC) transporter ID12_09345 ENOG4105C3U ABC transporter ID12_09350 ENOG4108JQ7 (ABC) transporter ID12_09355 ENOG4105DEF Extracellular solute-binding protein, family 5 ID12_09360 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ID12_09365 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ID12_09370 ENOG4107NBY Membrane ID12_09375 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ID12_09380 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ID12_09385 ENOG4105G5W regulator Fur family ID12_09535 ENOG4105E0M Sulfatase ID12_09555 ENOG4105E2Y ABC, transporter ID12_09560 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein ID12_09565 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component ID12_09570 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) ID12_09585 ENOG4105CJ1 ABC, transporter ID12_09620 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) ID12_09630 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ID12_09650 ENOG4105CYN Serine protein kinase ID12_09655 ENOG4106AKX UPF0229 protein ID12_09660 ENOG4105CW7 secretion protein, HlyD family ID12_09665 ENOG4105C0R drug resistance transporter emrb qaca subfamily ID12_09670 ENOG4105CS1 NAD(P)H quinone oxidoreductase ID12_09680 ENOG4105VEQ Cold shock protein ID12_09685 ENOG4105BZU Histidine kinase ID12_09715 ENOG4105BZU Histidine kinase ID12_09730 ENOG4108YBP pseudouridine synthase ID12_09745 ENOG4107YBY Hydrolase ID12_09750 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase ID12_09770 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR ID12_09775 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ID12_09780 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator ID12_09790 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ID12_09795 ENOG4105C6V Glycerol-3-phosphate dehydrogenase ID12_09805 ENOG4105BZU Histidine kinase ID12_09810 ENOG4105WH1 Two component transcriptional regulator luxr family ID12_09825 ENOG4105CH6 catalase ID12_09830 ENOG4105KPV Transcriptional regulator ID12_09835 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ID12_09840 ENOG4105ED1 spovr family ID12_09845 ENOG4105G6Z alkaline phosphatase ID12_09855 ENOG4105CUB amino acid ID12_09865 ENOG4105J37 ID12_09870 ENOG4108AEY RNA polymerase sigma factor ID12_09875 ENOG4105F6E Acyl-transferase ID12_09880 ENOG4105C37 (CBS) domain ID12_09890 ENOG4105C37 (CBS) domain ID12_09900 ENOG4106A8V Protein CrcB homolog ID12_09905 ENOG4105WMR Protein CrcB homolog ID12_09910 ENOG4108QXE glycerophosphoryl diester phosphodiesterase ID12_09920 ENOG4105D64 Mechanosensitive ion channel ID12_09925 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) ID12_09930 ENOG4107VMI polysaccharide deacetylase ID12_09935 ENOG4105F0I Aminotransferase ID12_09955 ENOG4105BZ1 (ABC) transporter ID12_09960 ENOG4105BZ1 (ABC) transporter ID12_10005 ENOG410839P ID12_10015 ENOG4108UH6 UPF0754 membrane protein ID12_10020 ENOG4105WZB UPF0342 protein ID12_10030 ENOG4105D4P Coproporphyrinogen iii oxidase ID12_10040 ENOG4107S91 Sodium hydrogen exchanger ID12_10045 ENOG4105NCW Trka-c domain protein ID12_10055 ENOG4105CGU Enoyl-CoA hydratase ID12_10065 ENOG4107VRP DNA repair exonuclease ID12_10070 ENOG4106D4I domain protein ID12_10085 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) ID12_10125 ENOG4105NBU tryptophan transport protein ID12_10130 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) ID12_10135 ENOG4105K59 histidine triad (HIT) protein ID12_10170 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation ID12_10175 ENOG4105BZ4 penicillin-binding protein ID12_10180 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) ID12_10185 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) ID12_10190 ENOG4105C1Q protoporphyrinogen oxidase ID12_10200 ENOG4105ECB domain protein ID12_10205 ENOG4105DER m42 family ID12_10220 ENOG4108RQ5 Beta-lactamase domain-containing protein ID12_10225 ENOG4105DF9 Lipoate-protein, ligase ID12_10230 ENOG4105CEY Amp-dependent synthetase and ligase ID12_10240 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 ID12_10250 ENOG4107TB6 phosphoglycerate mutase ID12_10255 ENOG4106YBV Methyl-accepting chemotaxis ID12_10275 ENOG4105XVF Competence transcription factor ID12_10290 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ID12_10295 ENOG4105C0R drug resistance transporter emrb qaca subfamily ID12_10300 ENOG41067XF inhibitor ID12_10305 ENOG4105DHS permease protein ID12_10310 ENOG4105CM4 permease protein ID12_10315 ENOG4108IPW abc transporter atp-binding protein ID12_10325 ENOG4108KGH TRANSCRIPTIONal ID12_10335 ENOG41060YP ID12_10350 ENOG4108KK1 membrane protein AbrB duplication ID12_10380 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation ID12_10390 ENOG4105EYH Exonuclease ID12_10450 ENOG4105ERH Fumarylacetoacetate hydrolase ID12_10455 ENOG4106BKT UPF0344 protein ID12_10465 ENOG4105CAQ asparagine synthetase ID12_10485 ENOG4105UQX Mate efflux family protein ID12_10490 ENOG4106HBX Transcriptional Regulator AraC Family ID12_10515 ENOG4105DY8 decarboxylase ID12_10560 ENOG4108VPT UPF0234 protein ID12_10565 ENOG4105QNR S1 RNA binding domain protein ID12_10570 ENOG4105DIH basic membrane ID12_10575 ENOG4105C8Q Methyl-accepting chemotaxis ID12_10580 ENOG4105EPR degv family ID12_10585 ENOG4107AYK membrAne ID12_10595 ENOG41073B9 ID12_10605 ENOG4108KP7 hydrolase ID12_10610 ENOG4108MXZ Esterase ID12_10615 ENOG4105VG1 fes assembly suf system protein ID12_10620 ENOG4105IQ5 FAD linked oxidase domain protein ID12_10630 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase ID12_10640 ENOG4105CAS nag kinase ID12_10645 ENOG4105C8Y Acetylornithine aminotransferase ID12_10650 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ID12_10660 ENOG4105DBV ornithine carbamoyltransferase ID12_10695 ENOG4107RMD Basic membrane lipoprotein ID12_10710 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ID12_10715 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ID12_10725 ENOG4105C3U ABC transporter ID12_10730 ENOG4108JQ7 (ABC) transporter ID12_10745 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ID12_10755 ENOG4105E6M Sulphatase-modifying factor protein ID12_10760 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) ID12_10790 ENOG4105C31 Tryptophanyl-tRNA synthetase ID12_10800 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ID12_10805 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ID12_10815 ENOG4108JQ7 (ABC) transporter ID12_10830 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) ID12_10835 ENOG4108ZCF integral membrane protein ID12_10840 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis ID12_10845 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ID12_10855 ENOG4105DPN Oligoendopeptidase f ID12_10865 ENOG4105T58 Dithiol-disulfide isomerase ID12_10870 ENOG4108Z18 K06886 hemoglobin ID12_10875 ENOG4105E4C Lytic transglycosylase catalytic ID12_10880 ENOG4105MIX Adenylate cyclase ID12_10885 ENOG4106EFP UPF0738 protein ID12_10895 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ID12_10900 ENOG4105EMS pseudouridine synthase ID12_10905 ENOG4107S1Q Phosphatase ID12_10915 ENOG4105ETU transcriptional activator (TenA ID12_10920 ENOG4108VEU Thiamine monophosphate synthase ID12_10935 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ID12_10940 ENOG4105D06 uba thif-type nad fad binding protein ID12_10945 ENOG4105DWF phosphomethylpyrimidine kinase ID12_10950 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH ID12_10955 ENOG4107A88 ID12_11010 ENOG4105ENA helicase ID12_11035 ENOG4105C28 cystathionine ID12_11040 ENOG4105C28 cystathionine ID12_11065 ENOG4105I03 Flagellin ID12_11090 ENOG4105E1F short-chain dehydrogenase reductase ID12_11110 ENOG4105DUM transcriptional regulator, lysR family ID12_11125 ENOG41068WN ID12_11130 ENOG4107V2S Transcriptional regulator ID12_11135 ENOG4105DJ2 Major Facilitator Superfamily ID12_11160 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ID12_11180 ENOG4105I03 Flagellin ID12_11185 ENOG4105I03 Flagellin ID12_11210 ENOG4105K7W phage-related replication protein ID12_11215 ENOG410635T phage-like element pbsx protein ID12_11225 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase ID12_11245 ENOG4105CJ3 phosphate transporter ID12_11250 ENOG4107GRR phosphate transport regulator ID12_11260 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ID12_11265 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein ID12_11270 ENOG4108I5D sulfate abc transporter ID12_11275 ENOG4105ECW sulfate abc transporter ID12_11290 ENOG4105DT3 PTS system, galactitol-specific IIc component ID12_11310 ENOG4107RUY (E1 component), alpha subunit ID12_11315 ENOG4105CPP Dehydrogenase, E1 component ID12_11320 ENOG4107QKR Dehydrogenase ID12_11330 ENOG41061TZ Short-chain dehydrogenase reductase Sdr ID12_11335 ENOG4105CHR reductase ID12_11340 ENOG4107RHR regulatoR ID12_11350 ENOG4107R7I amino acid ID12_11360 ENOG4105C0H protease ID12_11370 ENOG4108ME1 Peptidase M55 D-aminopeptidase ID12_11375 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ID12_11380 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ID12_11385 ENOG4105C3U ABC transporter ID12_11400 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ID12_11405 ENOG4105DTQ mandelate racemase muconate lactonizing ID12_11410 ENOG4107SN7 NLP P60 protein ID12_11415 ENOG4108JQ7 (ABC) transporter ID12_11420 ENOG4107TUM Amidinotransferase ID12_11425 ENOG4108S4H thioesterase Superfamily protein ID12_11430 ENOG4105K7K Transcriptional regulator ID12_11445 ENOG4108428 Inherit from COG: -acetyltransferase ID12_11450 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ID12_11455 ENOG410839T multidrug resistance protein ID12_11460 ENOG41080TC multidrug resistance protein ID12_11470 ENOG4105CIY formyltetrahydrofolate deformylase ID12_11475 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ID12_11480 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) ID12_11500 ENOG4105K56 Transcriptional regulator ID12_11505 ENOG4108ZHJ Organic hydroperoxide resistance protein ID12_11510 ENOG4107Y2X deaminase ID12_11515 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) ID12_11520 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin ID12_11535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ID12_11540 ENOG41062D9 Histidine kinase ID12_11550 ENOG4106849 propeptide, pepSY amd peptidase M4 ID12_11570 ENOG4105CJW magnesium transporter ID12_11590 ENOG4105V75 Transcriptional regulator ID12_11610 ENOG4105BZU Histidine kinase ID12_11615 ENOG4107T5V SNARE associated Golgi ID12_11620 ENOG4107TS3 membrane protein, TerC ID12_11625 ENOG4108WZW RNA polymerase sigma ID12_11635 ENOG410681C small acid-soluble spore protein ID12_11645 ENOG4105D0M Protease HtpX homolog ID12_11655 ENOG410900G Protein of unknown function (DUF421) ID12_11670 ENOG4108TGC Acyltransferase ID12_11675 ENOG4105BZU Histidine kinase ID12_11680 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ID12_11690 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) ID12_11695 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) ID12_11705 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate ID12_11710 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) ID12_11715 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) ID12_11720 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) ID12_11730 ENOG4105BZU Histidine kinase ID12_11735 ENOG41090MY MarR family Transcriptional regulator ID12_11740 ENOG4105ER2 Ompa motb domain protein ID12_11745 ENOG4105E14 MotA TolQ exbB proton channel ID12_11760 ENOG4108K88 Membrane ID12_11770 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) ID12_11775 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase ID12_11780 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) ID12_11785 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) ID12_11810 ENOG4105F0V Cell wall hydrolase ID12_11825 ENOG4105C59 p-type ATPase ID12_11830 ENOG4105DC7 peptidase M24 ID12_11845 ENOG4105CID antiterminator ID12_11855 ENOG4105KRI phosphocarrier protein (HPr ID12_11860 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) ID12_11870 ENOG4105F6S Spore photoproduct lyase ID12_11875 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer ID12_11880 ENOG4105CHR reductase ID12_11885 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ID12_11890 ENOG4105K4I Scp-like extracellular ID12_11900 ENOG4105BZU Histidine kinase ID12_11905 ENOG4105CHM Aminotransferase ID12_11920 ENOG41085PJ rdd domain containing protein ID12_11930 ENOG4107R88 Chemotaxis protein (CheV) ID12_11935 ENOG4105UIN ID12_11960 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein ID12_11970 ENOG4105K6S Short-chain dehydrogenase reductase Sdr ID12_11975 ENOG4105EPM Diguanylate phosphodiesterase ID12_11980 ENOG4105WEF catalase ID12_11985 ENOG4107IN1 Protein of unknown function (DUF1797) ID12_11990 ENOG4108XRC Protein of unknown function (DUF458) ID12_12025 ENOG4105NQC Flavodoxin ID12_12030 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) ID12_12040 ENOG4106AUC UPF0180 protein ID12_12045 ENOG4105D8X mechanosensitive ion channel ID12_12050 ENOG4105D3R alkyl hydroperoxide reductase ID12_12055 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ID12_12070 ENOG41080QG Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) ID12_12075 ENOG4105D06 uba thif-type nad fad binding protein ID12_12080 ENOG4105CVM Molybdenum cofactor synthesis domain protein ID12_12085 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein ID12_12090 ENOG4108ZAF Molybdopterin ID12_12095 ENOG41067WU Molybdopterin converting factor (Subunit 1) ID12_12110 ENOG4107X8C Efflux transporter RND family MFP subunit ID12_12115 ENOG4105C19 ABC transporter ID12_12120 ENOG4107RBB ABC transporter, permease ID12_12125 ENOG4105E98 transcriptional regulator DeoR family ID12_12130 ENOG4105DE4 1-phosphofructokinase ID12_12135 ENOG4105DM4 PTS System ID12_12150 ENOG4105C5H ABC transporter ID12_12185 ENOG4105BZU Histidine kinase ID12_12195 ENOG4107ZYR domain protein ID12_12200 ENOG4105CPN adenine deaminase ID12_12205 ENOG4105CN5 Metallo-Beta-Lactamase ID12_12215 ENOG4108X4Q Hydrolase ID12_12220 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ID12_12240 ENOG4105CPP Dehydrogenase, E1 component ID12_12245 ENOG4105C7S Dehydrogenase ID12_12250 ENOG4107QN2 dihydrolipoyl dehydrogenase ID12_12265 ENOG4105CXN decarboxylase ID12_12275 ENOG4108WQ8 UPF0637 protein ID12_12285 ENOG4105ECY inositol monophosphatase ID12_12320 ENOG4105CI3 gtp-binding protein typa ID12_12325 ENOG4105QA2 ID12_12340 ENOG4108IAB Phoh family ID12_12350 ENOG4105CSV Glutaminase ID12_12360 ENOG4105CNI cell division protein FtsW ID12_12365 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) ID12_12370 ENOG4105CVP deoxyribo-dipyrimidine photolyase ID12_12380 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) ID12_12390 ENOG4105BZ9 Cytochrome C oxidase, subunit I ID12_12395 ENOG4105CCU oxidase (Subunit III) ID12_12400 ENOG41064X9 cytochrome C oxidase subunit IV ID12_12415 ENOG41080XQ Signal transduction protein with cbs domains ID12_12420 ENOG4106UY4 Inherit from COG: Scp-like extracellular ID12_12445 ENOG4105WUC UPF0298 protein ID12_12450 ENOG4106H78 methyltransferase ID12_12455 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) ID12_12460 ENOG4105H20 Sporulation integral membrane protein YlbJ ID12_12465 ENOG4105D78 K07001 NTE family protein ID12_12470 ENOG41063PX domain protein ID12_12475 ENOG4105CDE UPF0348 protein ID12_12480 ENOG4105KNH Nucleic acid-binding protein ID12_12485 ENOG41067VY 50S ribosomal protein L32 ID12_12510 ENOG4108V6E Cell division protein mraZ ID12_12515 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ID12_12525 ENOG4105CJN penicillin-binding protein ID12_12530 ENOG4105CJN penicillin-binding protein ID12_12535 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ID12_12545 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) ID12_12550 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) ID12_12555 ENOG4105CNI cell division protein FtsW ID12_12560 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ID12_12565 ENOG4105D4A Cell wall formation (By similarity) ID12_12570 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) ID12_12575 ENOG4108R2U division initiation protein ID12_12585 ENOG4105K67 small basic protein ID12_12590 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) ID12_12595 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ID12_12610 ENOG4105FFI sigma-e processing peptidase spoiiga ID12_12615 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ID12_12625 ENOG4105DKT Transcriptional regulator ID12_12640 ENOG410787A Pts system, glucitol sorbitol-specific ID12_12645 ENOG4105DZY Pts system, glucitol sorbitol-specific ID12_12650 ENOG4105VI0 Pts system, glucitol sorbitol-specific ID12_12655 ENOG4105DKW ABC transporter ID12_12660 ENOG4105WR5 sporulation protein, YlmC YmxH family ID12_12665 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ID12_12670 ENOG4105DFA alanine racemase domain protein ID12_12675 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) ID12_12680 ENOG41067XK integral membrane protein ID12_12685 ENOG4105DBK s4 domain protein ID12_12695 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ID12_12705 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) ID12_12710 ENOG4105C34 Pseudouridine synthase ID12_12715 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) ID12_12725 ENOG4105CXT aspartate transcarbamylase ID12_12730 ENOG4105CD3 dihydroorotase ID12_12735 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ID12_12740 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain ID12_12745 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) ID12_12750 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) ID12_12755 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) ID12_12760 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) ID12_12770 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) ID12_12780 ENOG4107RIQ Sulfate adenylate transferase ID12_12785 ENOG4108WF4 Catalyzes the synthesis of activated sulfate (By similarity) ID12_12790 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ID12_12795 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein ID12_12800 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein ID12_12805 ENOG4105F23 Fibronectin-binding protein ID12_12815 ENOG4105DSJ YicC domain protein ID12_12820 ENOG4105KC4 UPF0296 protein ID12_12825 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) ID12_12835 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase ID12_12840 ENOG4105C25 Primosomal protein n' ID12_12845 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ID12_12850 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) ID12_12855 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ID12_12860 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs ID12_12865 ENOG4108ZF3 Phosphatase ID12_12870 ENOG4105D9P serine threonine protein kinase ID12_12875 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ID12_12880 ENOG4105DJV ribulose-phosphate 3-epimerase ID12_12885 ENOG4105FJ0 thiamine ID12_12895 ENOG4105VB9 50S ribosomal protein l28 ID12_12900 ENOG4108ZAA Alkaline-shock protein ID12_12905 ENOG4105DP4 dak2 domain fusion protein ylov ID12_12915 ENOG4105EJQ L-serine dehydratase ID12_12920 ENOG4105CB5 ATP-dependent DNA helicase recG ID12_12925 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) ID12_12930 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) ID12_12935 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase ID12_12940 ENOG4105CHR reductase ID12_12945 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ID12_12950 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) ID12_12955 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) ID12_12960 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ID12_12965 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) ID12_12975 ENOG4105K5M 30s ribosomal protein S16 ID12_12980 ENOG4108BW8 UPF0109 protein ID12_12990 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) ID12_12995 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) ID12_13000 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) ID12_13005 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) ID12_13010 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ID12_13020 ENOG4105VM1 flagellar ID12_13025 ENOG4105CMV Succinyl-CoA synthetase subunit beta ID12_13030 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha ID12_13035 ENOG4105C79 DNA protecting protein DprA ID12_13040 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ID12_13045 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) ID12_13050 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ID12_13055 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) ID12_13060 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) ID12_13070 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ID12_13075 ENOG4108ZC9 flagellar basal-body rod protein flgc ID12_13080 ENOG4105VQ0 flagellar hook-basal body complex protein fliE ID12_13085 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) ID12_13090 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ID12_13105 ENOG4106YF4 Flagellar biosynthesis chaperone ID12_13115 ENOG410696Y Flagellar hook-length control protein ID12_13120 ENOG410822I Flagellar hook capping protein ID12_13125 ENOG4108JQA flagellar ID12_13130 ENOG41068WV flagellar FlbD family protein ID12_13140 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ID12_13145 ENOG4105DD5 Flagellar motor switch protein ID12_13150 ENOG4107YTP response regulator receiver protein ID12_13160 ENOG4105CN7 Flagellar biosynthetic protein FliP ID12_13165 ENOG4105VS8 Flagellar biosynthetic protein fliq ID12_13170 ENOG4105D19 Role in flagellar biosynthesis (By similarity) ID12_13175 ENOG4105D00 flagellar biosynthetic protein flhB ID12_13180 ENOG4105D7B Flagellar biosynthesis protein flha ID12_13185 ENOG4105FZW flagellar biosynthesis regulator FlhF ID12_13195 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ID12_13200 ENOG4105CBS Chea signal transduction histidine kinase ID12_13205 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis ID12_13215 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) ID12_13220 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ID12_13230 ENOG4105CE9 30S ribosomal protein S2 ID12_13235 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) ID12_13245 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) ID12_13250 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ID12_13255 ENOG4105KNE Phosphatidate cytidylyltransferase ID12_13260 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) ID12_13265 ENOG4105DZP Membrane-associated zinc metalloprotease ID12_13270 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) ID12_13275 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) ID12_13285 ENOG4105CYP glycoside hydrolase, family ID12_13290 ENOG4105WJF ID12_13300 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) ID12_13305 ENOG4105CHV Transcription elongation factor NusA ID12_13310 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination ID12_13315 ENOG4105VHM ribosomal protein ID12_13320 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) ID12_13325 ENOG4105W7A Protein of unknown function (DUF503) ID12_13330 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) ID12_13335 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ID12_13340 ENOG4105DTN riboflavin biosynthesis protein ribF ID12_13345 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) ID12_13350 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) ID12_13360 ENOG4105C1V Peptidase, M16 ID12_13375 ENOG4105E35 Dipicolinate synthase subunit A ID12_13380 ENOG4108S0H Dipicolinic acid synthetase, b subunit ID12_13385 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ID12_13395 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ID12_13405 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit ID12_13415 ENOG4105CNU cell division protein FtsK ID12_13420 ENOG4105FDP GntR family transcriptional regulator ID12_13430 ENOG4105EYF MMPL domain protein ID12_13450 ENOG4105EYF MMPL domain protein ID12_13455 ENOG4108RKS Short-chain dehydrogenase reductase Sdr ID12_13460 ENOG4105XZV Protein of unknown function (DUF3243) ID12_13475 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase ID12_13480 ENOG4105CEV competence damage-inducible protein ID12_13485 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) ID12_13490 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) ID12_13495 ENOG4105D48 metallophosphoesterase ID12_13500 ENOG4105MCT stage V sporulation protein S ID12_13510 ENOG4105CPQ Dehydrogenase ID12_13515 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ID12_13525 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ID12_13540 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) ID12_13545 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) ID12_13570 ENOG4108VJ1 Transcriptional regulator (CarD family ID12_13575 ENOG4105K7W phage-related replication protein ID12_13585 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin ID12_13590 ENOG4105K7W phage-related replication protein ID12_13595 ENOG4108X3M OsmC Ohr family protein ID12_13625 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) ID12_13645 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) ID12_13650 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ID12_13655 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ID12_13660 ENOG4105U6W MutT NUDIX family protein ID12_13670 ENOG4106F1P AAA ATPase, central domain protein ID12_13680 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ID12_13685 ENOG4105CXI aluminum resistance protein ID12_13690 ENOG4105KV4 Transcriptional regulator ID12_13695 ENOG4105C5F glutamine synthetase ID12_13805 ENOG4108ZMX Domain of unknown function (DU1801) ID12_13825 ENOG410780I phosphoprotein phosphatase activity ID12_13840 ENOG4105XPP Protein of unknown function (DUF1275) ID12_13845 ENOG4105DQE DNA ligase ID12_13850 ENOG4105FDF Could be involved in DNA repair (By similarity) ID12_13855 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) ID12_13865 ENOG4108Z40 Transcriptional regulator ID12_13870 ENOG4105ECR NmrA family ID12_13880 ENOG4107R5T Cysteine-rich domain ID12_13885 ENOG4107QR9 Iron-sulfur cluster binding protein ID12_13890 ENOG41080R8 Conserved Protein ID12_13910 ENOG4108QY0 Membrane ID12_13915 ENOG41082JN Transcriptional regulator ID12_13920 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ID12_13925 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases ID12_13930 ENOG4105EDW glycosyl transferase, family 39 ID12_13935 ENOG4105WFK nuclease ID12_13940 ENOG4106SCS STAS domain ID12_13955 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ID12_13965 ENOG4108SVB resolvase ID12_13970 ENOG4105VPS UPF0291 protein ID12_13975 ENOG4105CV1 Transketolase (EC 2.2.1.1) ID12_13985 ENOG4105VXM UPF0154 protein ID12_13995 ENOG4107QIV Cytochrome c biogenesis protein ID12_14025 ENOG4108I0Z Aconitate hydratase ID12_14030 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ID12_14055 ENOG4105MI2 ID12_14060 ENOG4105W8X HesB YadR YfhF-family protein ID12_14065 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) ID12_14070 ENOG4105K4P CoA-binding domain protein ID12_14075 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ID12_14095 ENOG4106UW1 Major Facilitator superfamily ID12_14100 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ID12_14105 ENOG4108UW5 maltose o-acetyltransferase ID12_14110 ENOG4108UXE Protein tyrosine phosphatase ID12_14115 ENOG4107R5R arsenical pump membrane protein ID12_14120 ENOG41082YX Transcriptional regulator, arsr family ID12_14135 ENOG4107ZXU DSBA oxidoreductase ID12_14140 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) ID12_14150 ENOG4105ST3 Transcriptional regulator ID12_14155 ENOG4105DYS nad(p)h dehydrogenase (quinone) ID12_14160 ENOG4105KVH Transcriptional regulator ID12_14170 ENOG4105C6T cysteine synthase ID12_14175 ENOG4105KME endoribonuclease L-psp ID12_14190 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) ID12_14220 ENOG4105CS2 ec 3.2.1.21 ID12_14225 ENOG4105C5Y PTS System ID12_14245 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ID12_14255 ENOG4107SYN Glycosyl hydrolases family 43 ID12_14270 ENOG4105I1K ABC transporter ID12_14275 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component ID12_14295 ENOG4105UP7 3-epimerase ID12_14310 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia ID12_14320 ENOG4105KD7 acetyltransferase ID12_14325 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ID12_14370 ENOG4105DM4 PTS System ID12_14375 ENOG4105DM4 PTS System ID12_14380 ENOG4105DE4 1-phosphofructokinase ID12_14385 ENOG4105HX0 Transcriptional regulator ID12_14390 ENOG4107RZC phospholipase d ID12_14425 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ID12_14435 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ID12_14440 ENOG4107QX3 carboxylase ID12_14445 ENOG4105E39 Enoyl-CoA hydratase ID12_14455 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit ID12_14460 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ID12_14465 ENOG4105CEY Amp-dependent synthetase and ligase ID12_14470 ENOG4105C1G acyl-Coa dehydrogenase ID12_14475 ENOG4105F32 YngK protein ID12_14485 ENOG4105E98 transcriptional regulator DeoR family ID12_14490 ENOG41090U3 tautomerase ID12_14505 ENOG4105CQB FAD linked oxidase domain protein ID12_14510 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ID12_14520 ENOG4108B31 Spore germination protein ID12_14540 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ID12_14545 ENOG4107T5V SNARE associated Golgi ID12_14550 ENOG4105EXQ uroporphyrinogen iii synthase hem4 ID12_14560 ENOG4105DEN Luciferase family ID12_14580 ENOG4107QJQ Mate efflux family protein ID12_14585 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family ID12_14590 ENOG4105NBR Pectinesterase ID12_14595 ENOG4105H67 Protein of unknown function (DUF421) ID12_14600 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit ID12_14605 ENOG4108IFG nitrite reductase, (NAD(P)H) ID12_14610 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ID12_14625 ENOG4105BZ8 glutamate synthase ID12_14630 ENOG4105CBC glutamate synthase ID12_14635 ENOG4105C5Q Transcriptional regulator ID12_14645 ENOG4105BZ1 (ABC) transporter ID12_14650 ENOG41090E6 transcriptional regulator MERR family ID12_14655 ENOG4108UYN gCN5-related N-acetyltransferase ID12_14660 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) ID12_14665 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ID12_14670 ENOG4105II7 pyrroline-5-carboxylate reductase ID12_14680 ENOG4108J2R molybdopterin oxidoreductase ID12_14690 ENOG4105CMG Carbohydrate kinase ID12_14700 ENOG4105E2R ROK family ID12_14710 ENOG4105CT4 transporter ID12_14715 ENOG4108Z7R Chaperone CsaA ID12_14725 ENOG4105FVX ID12_14745 ENOG4108W8B Beta-lactamase domain protein ID12_14755 ENOG4105D29 Helix-turn-helix type 11 domain protein ID12_14770 ENOG4105KTU Transcriptional regulator, arsr family ID12_14775 ENOG4105CUB amino acid ID12_14785 ENOG4105CR4 methylisocitrate lyase ID12_14790 ENOG4105DXD 2-methylcitrate dehydratase ID12_14800 ENOG4108SJC Membrane ID12_14810 ENOG41069ER domain protein ID12_14815 ENOG4105C9U ATP-dependent DNA helicase RecQ ID12_14820 ENOG4105SCY DNAK suppressor ID12_14845 ENOG4105C26 Dehydrogenase ID12_14850 ENOG4105EWU Squalene--hopene cyclase ID12_14855 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ID12_14860 ENOG4105C09 Bile acid ID12_14865 ENOG4105C7S Dehydrogenase ID12_14870 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ID12_14875 ENOG4107T89 von Willebrand factor, type A ID12_14880 ENOG4105GMT ATPase associated with various cellular activities aaa_5 ID12_14890 ENOG4105K4H Nlp p60 protein ID12_14925 ENOG4105FR1 rard protein ID12_14955 ENOG4105E1V na solute symporter ID12_14975 ENOG4108VXD carboxy-peptidase ID12_14980 ENOG4105D3A purine nucleoside phosphorylase DeoD-type ID12_14985 ENOG4106Z5R ID12_14990 ENOG410841Q phosphoesterase PA-phosphatase related protein ID12_15010 ENOG4105VSD UPF0346 protein ID12_15020 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein ID12_15025 ENOG4108JUB Transcriptional regulator ID12_15055 ENOG4105C5E polysaccharide biosynthesis protein ID12_15060 ENOG4105E0X reductase ID12_15065 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) ID12_15090 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) ID12_15095 ENOG41090WU lipolytic protein G-D-S-L family ID12_15100 ENOG4108KF3 Electron transport protein SCO1 SenC ID12_15115 ENOG4105C7B Threonine dehydratase ID12_15125 ENOG4108UT2 hemolysin iii ID12_15135 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) ID12_15140 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) ID12_15160 ENOG4107YX5 Pfam:DUF548 ID12_15165 ENOG4108Y6J UPF0403 protein ID12_15170 ENOG4105C01 Dihydroxy-acid dehydratase ID12_15185 ENOG4108V06 Glutathione peroxidase ID12_15190 ENOG4105CKU formyltetrahydrofolate synthetase ID12_15195 ENOG4105CVG Homoserine O-transsuccinylase ID12_15200 ENOG4108QBV Monogalactosyldiacylglycerol synthase ID12_15235 ENOG41081VK Ribonuclease ID12_15260 ENOG410890F Dynamin family ID12_15270 ENOG41065KQ synthase ID12_15280 ENOG4107VMI polysaccharide deacetylase ID12_15285 ENOG4105C2W permease ID12_15295 ENOG4105CTD carboxy-peptidase ID12_15300 ENOG4105DVT helicase ID12_15310 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) ID12_15315 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) ID12_15320 ENOG4108UKS UPF0398 protein ID12_15330 ENOG4107X2U Inherit from COG: Exonuclease-like protein ID12_15335 ENOG4108I5C dEAD DEAH box helicase ID12_15340 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ID12_15380 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) ID12_15385 ENOG4105BZ4 penicillin-binding protein ID12_15395 ENOG4105CSM endonuclease III ID12_15420 ENOG4105DVT helicase ID12_15425 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) ID12_15430 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) ID12_15435 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) ID12_15445 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate ID12_15450 ENOG4105CPK Glycosyl transferase (Group 1 ID12_15455 ENOG4105FJR Lmbe family ID12_15460 ENOG4108Z5K methylglyoxal synthase ID12_15465 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) ID12_15470 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase ID12_15475 ENOG4108JYZ YitT family ID12_15495 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ID12_15510 ENOG4108SXZ UPF0302 protein ID12_15515 ENOG41068YB TPR repeat-containing protein ID12_15520 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase ID12_15530 ENOG4105CIH Imidazole acetol-phosphate transaminase ID12_15535 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) ID12_15540 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) ID12_15545 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase ID12_15550 ENOG4105DK0 Indole-3-glycerol phosphate synthase ID12_15555 ENOG4108I0Q anthranilate phosphoribosyltransferase ID12_15565 ENOG4105KHN chorismate mutase ID12_15570 ENOG4105D49 3-dehydroquinate synthase ID12_15575 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase ID12_15580 ENOG4105BZU Histidine kinase ID12_15585 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) ID12_15590 ENOG4105EAH synthase ID12_15595 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ID12_15600 ENOG4105XXQ heptaprenyl diphosphate synthase component I ID12_15610 ENOG4105EUJ GTP cyclohydrolase i ID12_15615 ENOG4105K70 DNA-binding protein ID12_15620 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) ID12_15635 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ID12_15640 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) ID12_15645 ENOG41065D1 ID12_15650 ENOG4105S2F ID12_15670 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ID12_15675 ENOG4105CAT Cytidine monophosphate kinase ID12_15690 ENOG4105MSI germination protein ypeb ID12_15700 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) ID12_15705 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase ID12_15720 ENOG4107RGJ metallophosphoesterase ID12_15735 ENOG4105I7S Abortive infection protein ID12_15740 ENOG4105C9U ATP-dependent DNA helicase RecQ ID12_15745 ENOG4105T7X ID12_15755 ENOG4108SAX Membrane ID12_15760 ENOG4108JQ1 Dehydrogenase ID12_15780 ENOG4105BZU Histidine kinase ID12_15785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ID12_15790 ENOG4105CRE cytochrome C ID12_15795 ENOG4107TWT Cytochrome c biogenesis protein ID12_15805 ENOG4105FE9 pseudouridine synthase ID12_15815 ENOG4108JIC nucleoside recognition domain protein ID12_15820 ENOG4105DZ1 carboxypeptidase ID12_15830 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) ID12_15835 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) ID12_15855 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ID12_15865 ENOG4108R6K riboflavin synthase, subunit alpha ID12_15890 ENOG4107ZE5 PPIases accelerate the folding of proteins ID12_15895 ENOG4105PTM secreted protein ID12_15900 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ID12_15910 ENOG4105G6R Stage v sporulation protein ae ID12_15920 ENOG4105CZ3 stage V sporulation protein ad ID12_15925 ENOG41090VF Stage v sporulation protein ac ID12_15940 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ID12_15945 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) ID12_15950 ENOG41082AN stage II sporulation protein ID12_15955 ENOG4105DZ1 carboxypeptidase ID12_15960 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) ID12_15965 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) ID12_15970 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ID12_15980 ENOG4105I3K Ferric uptake regulator, Fur family ID12_15985 ENOG4105MZ9 stage II sporulation protein m ID12_16000 ENOG4107YB6 acetyltransferase, (GNAT) family ID12_16010 ENOG4108YZ4 nudix hydrolase ID12_16015 ENOG4105CPC Aldo Keto reductase ID12_16040 ENOG4106HZJ ID12_16045 ENOG4108YQE rare lipoprotein a ID12_16050 ENOG4105RHY Pfam:UPF0157 ID12_16055 ENOG4108XET gCN5-related N-acetyltransferase ID12_16065 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ID12_16075 ENOG4105E5W Transporter ID12_16085 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase ID12_16095 ENOG4108IXY short-chain dehydrogenase reductase ID12_16100 ENOG41069FQ Metallo-beta-lactamase superfamily ID12_16110 ENOG4105II7 pyrroline-5-carboxylate reductase ID12_16125 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ID12_16135 ENOG4105XT2 Transcriptional regulator ID12_16140 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) ID12_16145 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase ID12_16150 ENOG4108TZY GntR Family Transcriptional Regulator ID12_16155 ENOG4105CS2 ec 3.2.1.21 ID12_16160 ENOG4105CK1 PTS System ID12_16165 ENOG4105VCP PTS System ID12_16170 ENOG4105VZJ PTS System ID12_16180 ENOG4105H9W Short-chain dehydrogenase reductase Sdr ID12_16185 ENOG4105CSC Glucose uptake protein ID12_16190 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) ID12_16195 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ID12_16205 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) ID12_16210 ENOG4108V3W Chemotaxis protein, CheW ID12_16215 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) ID12_16220 ENOG4108HNZ carboxyl transferase ID12_16225 ENOG4108ZVT methylmalonyl-coA epimerase ID12_16235 ENOG4108VZI ErfK ybiS ycfS ynhG family protein ID12_16240 ENOG4108QEG Membrane ID12_16245 ENOG4105CDA abc transporter atp-binding protein ID12_16250 ENOG4105E5Q amino acid AbC transporter ID12_16255 ENOG4108HW3 (ABC) transporter ID12_16260 ENOG4108Y6J UPF0403 protein ID12_16265 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) ID12_16275 ENOG4105C7S Dehydrogenase ID12_16280 ENOG4105CPP Dehydrogenase, E1 component ID12_16295 ENOG4105CKM Branched-chain carboxylic acid kinase ID12_16300 ENOG4107RDP Dehydrogenase ID12_16315 ENOG4108JUB Transcriptional regulator ID12_16320 ENOG4106CCJ Protein of unknown function (DUF2627) ID12_16325 ENOG4108QXE glycerophosphoryl diester phosphodiesterase ID12_16340 ENOG4107QQR Sporulation ID12_16345 ENOG4105S1Z Stage IV sporulation protein B ID12_16350 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ID12_16355 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) ID12_16360 ENOG4105DX0 Hemolysin A ID12_16365 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) ID12_16370 ENOG4105CTB Polyprenyl synthetase ID12_16375 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ID12_16380 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ID12_16385 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) ID12_16390 ENOG4105M7K Involved in the transcription termination process (By similarity) ID12_16395 ENOG4108ZSR alkaline shock protein ID12_16400 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ID12_16420 ENOG410644B Stage III sporulation protein af ID12_16430 ENOG4105KQ4 Stage iii sporulation protein ad ID12_16435 ENOG4108CQH stage III sporulation protein AC ID12_16440 ENOG4105KR5 Stage iii sporulation protein ID12_16445 ENOG4105CD2 stage iii sporulation protein aa ID12_16455 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ID12_16460 ENOG4105DC7 peptidase M24 ID12_16465 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) ID12_16475 ENOG4105CBJ Metal-dependent enzyme ID12_16490 ENOG4105KST dependent repressor ID12_16495 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) ID12_16500 ENOG4105WZW rhodanese family ID12_16505 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor ID12_16515 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) ID12_16520 ENOG4105C0D helicase ID12_16545 ENOG4105VFR signal peptidase ID12_16585 ENOG4106855 Competence protein ID12_16625 ENOG4105C5X domain protein ID12_16650 ENOG4105E0M Sulfatase ID12_16665 ENOG4107ZXI Rhomboid family ID12_16680 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase ID12_16685 ENOG4105WDJ 50S ribosomal protein L33 ID12_16700 ENOG41068DG YceG-like family ID12_16705 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ID12_16710 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ID12_16715 ENOG4105E2Z phosphate ABC transporter (Permease ID12_16720 ENOG4105C8U phosphate abc transporter ID12_16725 ENOG4105CVA phosphate ID12_16730 ENOG4107RF6 penicillin-binding protein ID12_16740 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ID12_16745 ENOG4105SXS Protein of unknown function (DUF456) ID12_16755 ENOG4105D9U N-acetyltransferase ID12_16765 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) ID12_16770 ENOG41063Y9 ID12_16775 ENOG4108U5J '-nucleotidase ID12_16780 ENOG41066F8 ROK family ID12_16785 ENOG4105N80 Ferric uptake regulator, Fur family ID12_16790 ENOG4105FAV ABC, transporter ID12_16795 ENOG4105FDK ABC transporter ID12_16800 ENOG4108JYZ YitT family ID12_16805 ENOG41069ZM Protein of unknown function (DUF2624) ID12_16810 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) ID12_16825 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) ID12_16830 ENOG4105EGD dinuclear metal center protein, YbgI family ID12_16845 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ID12_16850 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ID12_16855 ENOG4108UPT UPF0178 protein ID12_16860 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) ID12_16870 ENOG4105C38 Glycyl-tRNA synthetase beta subunit ID12_16875 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit ID12_16880 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) ID12_16890 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) ID12_16895 ENOG4105KG3 cytidine deaminase ID12_16900 ENOG4107YR5 Diacylglycerol kinase ID12_16905 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) ID12_16910 ENOG4105CTJ Metal Dependent Phosphohydrolase ID12_16915 ENOG4105C9A Phoh family ID12_16920 ENOG4105EI1 sporulation protein yqfd ID12_16925 ENOG41068P3 sporulation protein YqfC ID12_16935 ENOG4105DI5 UPF0365 protein ID12_16940 ENOG4105F7J membrane-bound serine protease ID12_16945 ENOG4105KTH gatB Yqey ID12_16960 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ID12_16965 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) ID12_16970 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) ID12_16975 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ID12_16985 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ ID12_16990 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) ID12_16995 ENOG4105CSA Coproporphyrinogen iii oxidase ID12_17000 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) ID12_17010 ENOG4108ZRV stage ii sporulation protein p ID12_17025 ENOG4105TQK DNA polymerase iii, delta' subunit ID12_17035 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 ID12_17040 ENOG4108UK2 deaminase ID12_17045 ENOG4105KQC Competence protein ID12_17055 ENOG4108D32 Methyltransferase ID12_17065 ENOG4108WF2 Metal Dependent Phosphohydrolase ID12_17070 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) ID12_17075 ENOG410812S Rna-binding protein ID12_17080 ENOG4105E2X shikimate dehydrogenase ID12_17085 ENOG4105CQW ribosome biogenesis GTPase YqeH ID12_17090 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase ID12_17120 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ID12_17145 ENOG4108ZJ4 polysaccharide deacetylase ID12_17180 ENOG4108IJ3 abc transporter atp-binding protein ID12_17200 ENOG4107QNK )-transporter ID12_17210 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) ID12_17225 ENOG4105CMD Transcriptional regulator, GntR family ID12_17235 ENOG4105NTK Transcriptional repressor Mpra ID12_17245 ENOG41080HJ 6-phospho 3-hexuloisomerase ID12_17250 ENOG4108VA3 3-hexulose-6-phosphate synthase ID12_17255 ENOG4105KVH Transcriptional regulator ID12_17325 ENOG4108HWY Beta-lactamase ID12_17330 ENOG4105FDT acyl-CoA dehydrogenase ID12_17350 ENOG4105E5Q amino acid AbC transporter ID12_17355 ENOG4105WEF catalase ID12_17375 ENOG4107EXU Short-chain dehydrogenase reductase Sdr ID12_17390 ENOG4107V2S Transcriptional regulator ID12_17395 ENOG4108KYE ABC-2 type transporter ID12_17400 ENOG41090VJ ABC-2 type transporter ID12_17405 ENOG4105CJ1 ABC, transporter ID12_17410 ENOG4105E2A Dehydrogenase ID12_17435 ENOG4105C28 cystathionine ID12_17445 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) ID12_17450 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) ID12_17465 ENOG4107XRG penicillin-binding protein ID12_17470 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ID12_17475 ENOG4107S03 uridine kinase ID12_17480 ENOG4105CFP Peptidase U32 ID12_17485 ENOG4105XYU peptidase (U32 family) ID12_17490 ENOG4108VQJ O-methyltransferase ID12_17495 ENOG4105HHA aminodeoxychorismate lyase ID12_17505 ENOG4107F3J Amp-dependent synthetase and ligase ID12_17510 ENOG4107ZYJ bioY protein ID12_17515 ENOG4105VPH UPF0473 protein ID12_17520 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) ID12_17525 ENOG4105VBH UPF0297 protein ID12_17535 ENOG4105C02 permease ID12_17540 ENOG4105CDA abc transporter atp-binding protein ID12_17545 ENOG4105CT1 (ABC) transporter ID12_17550 ENOG4105EAD ABC transporter ID12_17555 ENOG4105DRP amino acid AbC transporter ID12_17565 ENOG41060CR ID12_17575 ENOG4105C7H Helicase, RecD TraA family ID12_17585 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) ID12_17590 ENOG4105C3J Cysteine desulfurase ID12_17600 ENOG4105D1H recombination factor protein RarA ID12_17605 ENOG4105CUZ uba thif-type nad fad binding protein ID12_17610 ENOG4105C9M aspartyl-trna synthetase ID12_17615 ENOG4105CUT histidyl-tRNA synthetase ID12_17625 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ID12_17630 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) ID12_17635 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ID12_17640 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) ID12_17645 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) ID12_17650 ENOG41067VP Protein of unknown function (DUF1049) ID12_17655 ENOG4105NCW Trka-c domain protein ID12_17660 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ID12_17670 ENOG4105CKP Polysaccharide Biosynthesis Protein ID12_17675 ENOG4108QG2 Membrane ID12_17680 ENOG4105NAP ID12_17685 ENOG4105VIE preprotein translocase, subunit YajC ID12_17690 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) ID12_17695 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) ID12_17700 ENOG41061AI Protein of unknown function (DUF2905) ID12_17705 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) ID12_17710 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) ID12_17735 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) ID12_17750 ENOG4106678 morphogenetic protein associated with SpoVID ID12_17755 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) ID12_17760 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase ID12_17765 ENOG4108IYU L-aspartate oxidase ID12_17780 ENOG4105CQC Prephenate dehydratase ID12_17790 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control ID12_17800 ENOG4105K46 50S ribosomal protein l27 ID12_17805 ENOG4105X36 (ribosomal) protein ID12_17810 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) ID12_17825 ENOG4107QMS site-determining protein ID12_17830 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) ID12_17835 ENOG4105YHC Rod shape-determining protein MreD ID12_17840 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) ID12_17845 ENOG4105DFF Rod shape-determining protein mreb ID12_17850 ENOG4105W5Q DNA repair protein (RadC ID12_17855 ENOG4108Z03 MAF-like protein ID12_17865 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) ID12_17870 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ID12_17875 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) ID12_17885 ENOG4106AR7 Spore coat protein ID12_17890 ENOG41068KH stage VI sporulation protein D ID12_17895 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ID12_17900 ENOG4105D52 delta-aminolevulinic acid dehydratase ID12_17910 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) ID12_17920 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) ID12_17930 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) ID12_17935 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) ID12_17940 ENOG4108IUQ atp-dependent protease ID12_17945 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) ID12_17950 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation ID12_17960 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ID12_17965 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ID12_17970 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ID12_17975 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ID12_17980 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ID12_17985 ENOG4108ZP8 Acetolactate synthase small subunit ID12_17990 ENOG4105C7K acetolactate synthase ID12_17995 ENOG4105CM2 brancheD-chain amino acid aminotransferase ID12_18005 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) ID12_18015 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD ID12_18025 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein ID12_18030 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) ID12_18080 ENOG4105M59 Phosphodiesterase, mj0936 family ID12_18085 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ID12_18090 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) ID12_18095 ENOG4108XJQ germination protein ID12_18100 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) ID12_18105 ENOG41067TZ transcriptional regulator, MarR family ID12_18110 ENOG4105PFC Transcriptional regulator ID12_18120 ENOG4108KAM Transcriptional regulator ID12_18125 ENOG4105C7F AcnD-accessory protein PrpF ID12_18130 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase ID12_18140 ENOG4105E33 succinate dehydrogenase ID12_18150 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit ID12_18160 ENOG4105CFH Aspartokinase ID12_18165 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) ID12_18170 ENOG4105K63 Thioredoxin ID12_18175 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) ID12_18180 ENOG4105C10 Electron transfer flavoprotein ID12_18185 ENOG4105BZJ Electron transfer flavoprotein ID12_18190 ENOG41060WC Enoyl-CoA hydratase ID12_18195 ENOG4107Z3H Transcriptional regulator, TetR family ID12_18200 ENOG4105CEY Amp-dependent synthetase and ligase ID12_18215 ENOG4105C98 muts2 protein ID12_18220 ENOG4105DCG PHP domain protein ID12_18230 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) ID12_18235 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ID12_18240 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ID12_18245 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) ID12_18250 ENOG4108RWN rrna methyltransferase ID12_18255 ENOG41067MF small acid-soluble spore protein ID12_18265 ENOG4105CN9 Peptidase m42 family protein ID12_18275 ENOG410696E Membrane ID12_18280 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ID12_18285 ENOG4105VJV 50s ribosomal protein L35 ID12_18290 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) ID12_18305 ENOG4105U0R haloacid dehalogenase-like hydrolase ID12_18310 ENOG4107SDU Methyl-accepting chemotaxis ID12_18315 ENOG4105C22 threonyL-tRNA synthetase ID12_18320 ENOG4108TDW sporulation protein YtxC ID12_18340 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) ID12_18350 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) ID12_18355 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ID12_18360 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ID12_18370 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) ID12_18375 ENOG4105C2M dna polymerase I ID12_18380 ENOG4105BZU Histidine kinase ID12_18385 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ID12_18390 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) ID12_18395 ENOG4108HMX isocitrate dehydrogenase (NADP) ID12_18400 ENOG4105BZN citrate synthase ID12_18405 ENOG4107CWS Protein of unknown function (DUF441) ID12_18410 ENOG4108REF Sporulation integral membrane protein ytvi ID12_18415 ENOG4105FS0 cytoplasmic membrane protein ID12_18420 ENOG4105CA9 Pyruvate kinase ID12_18425 ENOG4105CTQ phosphohexokinase ID12_18435 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) ID12_18440 ENOG4105C6K Malic enzyme ID12_18445 ENOG4105C0B DNA polymerase III (alpha subunit) ID12_18450 ENOG4105VV2 ID12_18460 ENOG4106EVM ID12_18465 ENOG4105SFS phosphoesterase RecJ domain protein ID12_18485 ENOG4105E8R UPF0173 metal-dependent hydrolase ID12_18500 ENOG4105CH7 arginosuccinase ID12_18505 ENOG4105CDH Citrulline--aspartate ligase ID12_18510 ENOG4105EPU Molybdenum cofactor synthesis domain protein ID12_18515 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ID12_18525 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) ID12_18530 ENOG4105KBJ sporulation protein ytfj ID12_18540 ENOG4105VK3 rdd domain containing protein ID12_18545 ENOG4105D07 Signal peptide peptidase, SppA ID12_18550 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ID12_18555 ENOG4105C1J atp-dependent rna helicase ID12_18560 ENOG4105ECK Fatty Acid Desaturase ID12_18570 ENOG4108ZGX Histidine kinase ID12_18575 ENOG4108S01 response regulator ID12_18585 ENOG4105CJZ response regulator ID12_18590 ENOG4105EWM Histidine kinase ID12_18595 ENOG4105CNI cell division protein FtsW ID12_18605 ENOG4105C19 ABC transporter ID12_18615 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) ID12_18620 ENOG4108X0B nad(p)h dehydrogenase (quinone) ID12_18640 ENOG4108ZUB Lysine exporter protein (Lyse ygga) ID12_18645 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ID12_18655 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) ID12_18685 ENOG4105U5Y Transcriptional regulator ID12_18700 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ID12_18720 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold ID12_18725 ENOG4105KAC Antibiotic biosynthesis monooxygenase ID12_18730 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ID12_18740 ENOG4105F1V Acetoin utilization protein ID12_18745 ENOG4105W87 Cbs domain ID12_18750 ENOG4105DGU Histone deacetylase ID12_18755 ENOG4105ETE Transcriptional regulator (LacI family ID12_18760 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase ID12_18780 ENOG4105DFU Cell wall formation (By similarity) ID12_18790 ENOG4108VDD TRNA binding domain protein ID12_18795 ENOG4108NKM UPF0354 protein ID12_18810 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ ID12_18825 ENOG4105C6K Malic enzyme ID12_18830 ENOG4105C8F Beta-lactamase domain protein ID12_18835 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) ID12_18845 ENOG4108V15 phosphotransferase enzyme family ID12_18860 ENOG4107F58 2'-5' rna ligase ID12_18865 ENOG4105C6T cysteine synthase ID12_18870 ENOG4107UIE peptidase ID12_18875 ENOG4107QSE Dipeptidase ID12_18880 ENOG4105C7N Xanthine uracil vitamin C permease ID12_18885 ENOG4105YW5 deoR family transcriptional regulator ID12_18900 ENOG4105CBX hi0933 family ID12_18910 ENOG4105C94 Transporter ID12_18915 ENOG4106611 bacteriocin immunity ID12_18925 ENOG41085GJ domain protein ID12_18930 ENOG4105MU9 integral membrane protein ID12_18935 ENOG4105DDC Oxidoreductase domain protein ID12_18945 ENOG4105F5H Glycosyl Hydrolase Family 88 ID12_18955 ENOG41075H3 AraC family transcriptional regulator ID12_18960 ENOG4105KVH Transcriptional regulator ID12_18965 ENOG4105F27 Major Facilitator ID12_18970 ENOG4105CV8 reductase ID12_18980 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component ID12_18995 ENOG4105NTD Inherit from COG: Hydrolase ID12_19000 ENOG4105C8T Leucyl-tRNA synthetase ID12_19015 ENOG4105BZU Histidine kinase ID12_19020 ENOG4106UBQ ID12_19025 ENOG4107R34 abc transporter permease protein ID12_19030 ENOG4105C19 ABC transporter ID12_19040 ENOG4105DVE abc transporter atp-binding protein ID12_19045 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family ID12_19060 ENOG4105N5T Radical SAM Protein ID12_19070 ENOG4108N23 SpoOM-related protein ID12_19080 ENOG4105E8V Alpha Beta Hydrolase Fold protein ID12_19085 ENOG4108Z0R Transferase ID12_19090 ENOG4105CAQ asparagine synthetase ID12_19095 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP ID12_19115 ENOG4105EWK phytoene ID12_19135 ENOG4105D2X ABC transporter substrate-binding protein ID12_19145 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component ID12_19155 ENOG4106FN3 tellurium resistance protein ID12_19180 ENOG4108RMU ferritin dps family protein ID12_19195 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) ID12_19200 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) ID12_19205 ENOG4108V2W Carbonate dehydratase ID12_19210 ENOG4105DSE periplasmic solute binding protein ID12_19215 ENOG4105NRA 50s ribosomal protein l31 type b ID12_19240 ENOG4105DTQ mandelate racemase muconate lactonizing ID12_19250 ENOG4108IPT Naphthoate synthase ID12_19255 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) ID12_19260 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) ID12_19265 ENOG4105E4F Isochorismate synthase ID12_19270 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase ID12_19280 ENOG4108606 TspO/MBR family