locus-tag	class	description
KIV12_00010	COG1301	dicarboxylic acid transport
KIV12_00015	COG0628	permease
KIV12_00020	COG1301	dicarboxylic acid transport
KIV12_00025	COG4565	transcriptional regulatory protein
KIV12_00030	COG3290	protein histidine kinase activity
KIV12_00035	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KIV12_00040	COG2217	Heavy metal translocating P-type atpase
KIV12_00045	COG2261	transglycosylase associated protein
KIV12_00050	COG1914	H( )-stimulated, divalent metal cation uptake system
KIV12_00055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KIV12_00075	COG5444	nuclease activity
KIV12_00080	COG0028	Belongs to the TPP enzyme family
KIV12_00085	COG0531	amino acid
KIV12_00095	COG1215	transferase activity, transferring glycosyl groups
KIV12_00100	COG5298	Protein conserved in bacteria
KIV12_00105	COG3706	GGDEF domain
KIV12_00110	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KIV12_00115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KIV12_00115	COG0551	DNA topoisomerase type I activity
KIV12_00120	COG0473	3-isopropylmalate dehydrogenase activity
KIV12_00125	COG0697	spore germination
KIV12_00130	COG1917	Cupin 2, conserved barrel domain protein
KIV12_00130	COG2207	Transcriptional regulator
KIV12_00135	COG1802	Transcriptional regulator
KIV12_00140	COG2814	Major facilitator Superfamily
KIV12_00160	COG3871	stress protein (general stress protein 26)
KIV12_00165	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_00170	COG2226	methyltransferase
KIV12_00175	COG3711	transcriptional antiterminator
KIV12_00185	COG2755	lipolytic protein G-D-S-L family
KIV12_00190	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KIV12_00195	COG1414	Transcriptional regulator
KIV12_00200	COG1984	allophanate hydrolase subunit 2
KIV12_00205	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KIV12_00210	COG4336	lyase activity
KIV12_00215	COG1914	H( )-stimulated, divalent metal cation uptake system
KIV12_00220	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KIV12_00225	COG0457	Tetratricopeptide repeat
KIV12_00255	COG0561	phosphatase activity
KIV12_00265	COG0346	lactoylglutathione lyase activity
KIV12_00300	COG0840	transmembrane signaling receptor activity
KIV12_00305	COG0246	Mannitol dehydrogenase
KIV12_00310	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KIV12_00315	COG2213	PTS system mannitol-specific
KIV12_00320	COG1276	copper resistance
KIV12_00320	COG2372	response to copper ion
KIV12_00325	COG4549	nuclear export factor GLE1
KIV12_00330	COG2249	NAD(P)H dehydrogenase (quinone) activity
KIV12_00335	COG1012	belongs to the aldehyde dehydrogenase family
KIV12_00340	COG0531	amino acid
KIV12_00345	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KIV12_00350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KIV12_00355	COG0583	DNA-binding transcription factor activity
KIV12_00365	COG0640	Transcriptional regulator
KIV12_00375	COG1309	transcriptional regulator
KIV12_00380	COG2814	Major facilitator Superfamily
KIV12_00385	COG0527	aspartate kinase activity
KIV12_00390	COG1366	Belongs to the anti-sigma-factor antagonist family
KIV12_00395	COG3850	Histidine kinase
KIV12_00395	COG5002	protein histidine kinase activity
KIV12_00400	COG0745	RESPONSE REGULATOR receiver
KIV12_00420	COG2079	MmgE PrpD family protein
KIV12_00425	COG1473	amidohydrolase
KIV12_00430	COG1126	abc transporter atp-binding protein
KIV12_00435	COG0765	amino acid transport
KIV12_00440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KIV12_00445	COG0456	acetyltransferase
KIV12_00450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KIV12_00455	COG5434	Belongs to the glycosyl hydrolase 28 family
KIV12_00460	COG3104	oligopeptide transport
KIV12_00465	COG0833	amino acid
KIV12_00470	COG0412	Dienelactone hydrolase
KIV12_00475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KIV12_00480	COG0765	amino acid transport
KIV12_00485	COG1126	abc transporter atp-binding protein
KIV12_00490	COG2002	toxin-antitoxin pair type II binding
KIV12_00500	COG0737	Belongs to the 5'-nucleotidase family
KIV12_00505	COG2364	Membrane
KIV12_00515	COG2207	Transcriptional regulator
KIV12_00515	COG3708	Transcriptional regulator
KIV12_00525	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KIV12_00530	COG0697	spore germination
KIV12_00540	COG4555	ABC transporter
KIV12_00545	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KIV12_00560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KIV12_00565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KIV12_00570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KIV12_00580	COG1176	ABC-type spermidine putrescine transport system, permease component I
KIV12_00585	COG3842	ATPase activity
KIV12_00605	COG3209	COG3209 Rhs family protein
KIV12_00610	COG3290	protein histidine kinase activity
KIV12_00610	COG0840	transmembrane signaling receptor activity
KIV12_00620	COG2746	aminoglycoside 3-N-acetyltransferase activity
KIV12_00625	COG1522	sequence-specific DNA binding
KIV12_00630	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KIV12_00640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KIV12_00645	COG0765	amino acid transport
KIV12_00650	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KIV12_00655	COG2508	Transcriptional regulator
KIV12_00660	COG1012	belongs to the aldehyde dehydrogenase family
KIV12_00665	COG0506	proline dehydrogenase activity
KIV12_00670	COG3541	Predicted nucleotidyltransferase
KIV12_00680	COG3458	cephalosporin-C deacetylase activity
KIV12_00685	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KIV12_00690	COG0583	DNA-binding transcription factor activity
KIV12_00695	COG2226	methyltransferase
KIV12_00700	COG0477	Major facilitator Superfamily
KIV12_00710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KIV12_00715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KIV12_00730	COG2271	Major facilitator Superfamily
KIV12_00735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KIV12_00745	COG0028	Belongs to the TPP enzyme family
KIV12_00750	COG0710	3-dehydroquinate dehydratase activity
KIV12_00755	COG1012	belongs to the aldehyde dehydrogenase family
KIV12_00770	COG0457	Tetratricopeptide repeat
KIV12_00785	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KIV12_00790	COG3665	Urea carboxylase-associated protein
KIV12_00795	COG1113	amino acid transport
KIV12_00800	COG3403	YqcI/YcgG family
KIV12_00815	COG1280	lysine exporter protein (LysE YggA)
KIV12_00820	COG0738	Major facilitator superfamily
KIV12_00825	COG0673	inositol 2-dehydrogenase activity
KIV12_00830	COG0561	phosphatase activity
KIV12_00835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KIV12_00840	COG1609	Transcriptional regulator
KIV12_00845	COG1620	l-lactate permease
KIV12_00850	COG0039	L-malate dehydrogenase activity
KIV12_00855	COG1288	antiporter activity
KIV12_00860	COG1473	amidohydrolase
KIV12_00875	COG2113	Glycine betaine
KIV12_00880	COG4176	ABC-type proline glycine betaine transport system permease component
KIV12_00885	COG0517	IMP dehydrogenase activity
KIV12_00885	COG4175	Glycine betaine
KIV12_00890	COG3853	Toxic anion resistance protein (TelA)
KIV12_00920	COG0861	Integral membrane protein TerC family
KIV12_00925	COG2310	stress, protein
KIV12_00930	COG2310	stress, protein
KIV12_00935	COG2310	stress, protein
KIV12_00940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KIV12_00950	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_00955	COG3773	Cell wall hydrolase
KIV12_00970	COG1668	transmembrane transport
KIV12_00975	COG4555	ABC transporter
KIV12_00980	COG3279	Response regulator of the LytR AlgR family
KIV12_00985	COG3290	protein histidine kinase activity
KIV12_00990	COG0667	Aldo Keto reductase
KIV12_01000	COG1405	negative regulation of cell septum assembly
KIV12_01000	COG3012	SEC-C Motif Domain Protein
KIV12_01005	COG0784	Response regulator, receiver
KIV12_01010	COG4191	Histidine kinase
KIV12_01015	COG2066	Belongs to the glutaminase family
KIV12_01020	COG1115	amino acid carrier protein
KIV12_01025	COG0596	Alpha beta hydrolase
KIV12_01035	COG0531	amino acid
KIV12_01040	COG0318	PFAM AMP-dependent synthetase and ligase
KIV12_01045	COG1846	Transcriptional regulator
KIV12_01050	COG1063	alcohol dehydrogenase
KIV12_01055	COG1917	Cupin 2, conserved barrel domain protein
KIV12_01060	COG1309	transcriptional regulator
KIV12_01070	COG1404	Belongs to the peptidase S8 family
KIV12_01085	COG0456	acetyltransferase
KIV12_01090	COG2814	Major facilitator Superfamily
KIV12_01110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KIV12_01115	COG2040	homocysteine
KIV12_01120	COG0833	amino acid
KIV12_01135	COG1404	Belongs to the peptidase S8 family
KIV12_01140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KIV12_01140	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KIV12_01145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KIV12_01150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KIV12_01155	COG0383	alpha-mannosidase activity
KIV12_01160	COG1940	carbohydrate kinase activity
KIV12_01165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KIV12_01165	COG3711	transcriptional antiterminator
KIV12_01185	COG2723	6-phospho-beta-galactosidase activity
KIV12_01190	COG1263	PTS System
KIV12_01190	COG2190	(PTS) system
KIV12_01190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KIV12_01195	COG3711	transcriptional antiterminator
KIV12_01205	COG0531	amino acid
KIV12_01210	COG1054	Belongs to the UPF0176 family
KIV12_01215	COG0371	Dehydrogenase
KIV12_01220	COG0656	L-ascorbic acid biosynthetic process
KIV12_01230	COG1683	Conserved Protein
KIV12_01235	COG1846	Transcriptional regulator
KIV12_01250	COG2814	Major facilitator Superfamily
KIV12_01255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KIV12_01265	COG0730	response to heat
KIV12_01270	COG0425	Belongs to the sulfur carrier protein TusA family
KIV12_01275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KIV12_01275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KIV12_01280	COG0425	Belongs to the sulfur carrier protein TusA family
KIV12_01280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KIV12_01290	COG2210	Belongs to the sulfur carrier protein TusA family
KIV12_01295	COG1937	Protein conserved in bacteria
KIV12_01310	COG0640	Transcriptional regulator
KIV12_01330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KIV12_01340	COG1331	Highly conserved protein containing a thioredoxin domain
KIV12_01350	COG2271	Major facilitator Superfamily
KIV12_01355	COG0584	glycerophosphoryl diester phosphodiesterase
KIV12_01360	COG1113	amino acid transport
KIV12_01375	COG1309	transcriptional regulator
KIV12_01380	COG2207	Transcriptional regulator
KIV12_01395	COG1476	TRANSCRIPTIONal
KIV12_01415	COG2311	Membrane
KIV12_01430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIV12_01435	COG1413	lyase activity
KIV12_01445	COG1131	(ABC) transporter
KIV12_01450	COG1266	CAAX protease self-immunity
KIV12_01455	COG0535	radical SAM domain protein
KIV12_01470	COG1695	Transcriptional regulator
KIV12_01480	COG1136	(ABC) transporter
KIV12_01480	COG0577	efflux transmembrane transporter activity
KIV12_01490	COG1131	(ABC) transporter
KIV12_01510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KIV12_01520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KIV12_01525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KIV12_01530	COG4856	YbbR-like protein
KIV12_01535	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KIV12_01540	COG5662	AntiSigma factor
KIV12_01545	COG1595	DNA-templated transcription, initiation
KIV12_01580	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KIV12_01585	COG1737	Transcriptional regulator
KIV12_01590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KIV12_01590	COG1263	PTS System
KIV12_01595	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KIV12_01600	COG1472	Belongs to the glycosyl hydrolase 3 family
KIV12_01605	COG3876	Protein conserved in bacteria
KIV12_01610	COG0385	Bile acid
KIV12_01615	COG0659	secondary active sulfate transmembrane transporter activity
KIV12_01645	COG0726	polysaccharide deacetylase
KIV12_01650	COG2194	sulfuric ester hydrolase activity
KIV12_01660	COG0489	protein tyrosine kinase activity
KIV12_01665	COG0860	N-Acetylmuramoyl-L-alanine amidase
KIV12_01690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KIV12_01695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KIV12_01700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KIV12_01705	COG0101	tRNA pseudouridine synthase activity
KIV12_01710	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KIV12_01715	COG1122	ATPase activity
KIV12_01720	COG1122	ATPase activity
KIV12_01725	COG0203	ribosomal protein L17
KIV12_01730	COG0202	RNA polymerase activity
KIV12_01735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KIV12_01740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KIV12_01745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KIV12_01750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KIV12_01755	COG0024	Methionine aminopeptidase
KIV12_01760	COG0563	adenylate kinase activity
KIV12_01765	COG0201	protein transport
KIV12_01770	COG0200	Binds to the 23S rRNA
KIV12_01775	COG1841	ribosomal large subunit assembly
KIV12_01780	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KIV12_01785	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KIV12_01790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KIV12_01795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KIV12_01800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KIV12_01805	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KIV12_01810	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KIV12_01815	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KIV12_01820	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KIV12_01825	COG0255	Belongs to the universal ribosomal protein uL29 family
KIV12_01830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KIV12_01835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KIV12_01840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KIV12_01845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KIV12_01850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KIV12_01855	COG0089	rRNA binding
KIV12_01860	COG0088	Forms part of the polypeptide exit tunnel
KIV12_01865	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KIV12_01875	COG0596	Alpha beta hydrolase
KIV12_01880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KIV12_01885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KIV12_01890	COG0049	tRNA binding
KIV12_01895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KIV12_01900	COG1358	cellular component organization or biogenesis
KIV12_01905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
KIV12_01910	COG0085	RNA polymerase activity
KIV12_01915	COG2813	Specifically methylates the guanine in position
KIV12_01920	COG0222	ribosome binding
KIV12_01925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KIV12_01930	COG0081	regulation of translation
KIV12_01940	COG0250	Participates in transcription elongation, termination and antitermination
KIV12_01945	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KIV12_01950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KIV12_01955	COG1595	DNA-templated transcription, initiation
KIV12_01960	COG3688	RNA-binding protein containing a PIN domain
KIV12_01965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KIV12_01970	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KIV12_01975	COG0215	cysteine-tRNA ligase activity
KIV12_01980	COG1045	serine acetyltransferase
KIV12_01985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KIV12_01990	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KIV12_01995	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KIV12_02000	COG4956	integral membrane protein (PIN domain superfamily)
KIV12_02005	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
KIV12_02010	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KIV12_02015	COG0542	response to heat
KIV12_02020	COG3869	Catalyzes the specific phosphorylation of arginine residues in
KIV12_02025	COG3880	PFAM UvrB UvrC protein
KIV12_02030	COG4463	regulation of RNA biosynthetic process
KIV12_02110	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KIV12_02115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KIV12_02120	COG1396	sequence-specific DNA binding
KIV12_02125	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KIV12_02130	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KIV12_02135	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KIV12_02140	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KIV12_02145	COG0512	Glutamine amidotransferase of anthranilate synthase
KIV12_02150	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KIV12_02155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KIV12_02160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KIV12_02165	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KIV12_02170	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KIV12_02175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KIV12_02180	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KIV12_02185	COG0037	tRNA processing
KIV12_02190	COG0515	serine threonine protein kinase
KIV12_02195	COG2304	oxidoreductase activity
KIV12_02200	COG2208	phosphoserine phosphatase activity
KIV12_02215	COG1098	S1 RNA binding domain
KIV12_02220	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KIV12_02235	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KIV12_02240	COG3956	TIGRFAM MazG family protein
KIV12_02245	COG2244	polysaccharide biosynthetic process
KIV12_02250	COG2002	toxin-antitoxin pair type II binding
KIV12_02255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KIV12_02265	COG0193	aminoacyl-tRNA hydrolase activity
KIV12_02270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KIV12_02275	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KIV12_02285	COG2088	sporulation resulting in formation of a cellular spore
KIV12_02290	COG0251	oxidation-reduction process
KIV12_02295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KIV12_02300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KIV12_02310	COG4466	Protein conserved in bacteria
KIV12_02320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KIV12_02325	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KIV12_02330	COG3583	domain protein
KIV12_02330	COG3584	3D domain protein
KIV12_02335	COG0084	hydrolase, TatD family'
KIV12_02340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KIV12_02340	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KIV12_02345	COG2002	toxin-antitoxin pair type II binding
KIV12_02350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KIV12_02355	COG2827	Endonuclease containing a URI domain
KIV12_02360	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KIV12_02365	COG4467	Involved in initiation control of chromosome replication
KIV12_02370	COG1774	PSP1 C-terminal conserved region
KIV12_02375	COG0470	DNA polymerase III
KIV12_02380	COG1728	Protein conserved in bacteria
KIV12_02385	COG3870	Protein conserved in bacteria
KIV12_02390	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KIV12_02395	COG1982	Orn Lys Arg decarboxylase major
KIV12_02400	COG3853	Toxic anion resistance protein (TelA)
KIV12_02405	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
KIV12_02450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KIV12_02455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KIV12_02460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KIV12_02470	COG0590	tRNA wobble adenosine to inosine editing
KIV12_02475	COG1335	isochorismatase
KIV12_02480	COG3858	chitin binding
KIV12_02480	COG1388	LysM domain
KIV12_02485	COG1428	Deoxynucleoside kinase
KIV12_02490	COG1428	Deoxynucleoside kinase
KIV12_02500	COG0840	transmembrane signaling receptor activity
KIV12_02505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KIV12_02510	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KIV12_02515	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KIV12_02520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KIV12_02525	COG1686	Belongs to the peptidase S11 family
KIV12_02530	COG0516	GMP reductase activity
KIV12_02530	COG0517	IMP dehydrogenase activity
KIV12_02565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KIV12_02570	COG0187	DNA topoisomerase II activity
KIV12_02580	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KIV12_02585	COG2501	S4 domain
KIV12_02590	COG0592	DNA-directed DNA polymerase activity
KIV12_02595	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KIV12_02600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KIV12_02605	COG0594	ribonuclease P activity
KIV12_02610	COG0706	membrane insertase activity
KIV12_02615	COG1847	R3H domain protein
KIV12_02620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KIV12_02625	COG0445	tRNA wobble uridine modification
KIV12_02630	COG0357	Ribosomal RNA small subunit methyltransferase G
KIV12_02635	COG1475	DNA binding
KIV12_02645	COG1192	Involved in chromosome partitioning
KIV12_02650	COG1475	DNA binding
KIV12_02660	COG3949	Membrane
KIV12_02675	COG4481	Protein conserved in bacteria
KIV12_02680	COG0012	GTP binding
KIV12_02685	COG0360	Binds together with S18 to 16S ribosomal RNA
KIV12_02690	COG0629	single-stranded DNA binding
KIV12_02695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KIV12_02700	COG1125	glycine betaine transport
KIV12_02700	COG0517	IMP dehydrogenase activity
KIV12_02705	COG1174	glycine betaine transport
KIV12_02710	COG0346	lactoylglutathione lyase activity
KIV12_02715	COG0400	carboxylic ester hydrolase activity
KIV12_02720	COG0655	NAD(P)H dehydrogenase (quinone) activity
KIV12_02725	COG0753	catalase activity
KIV12_02735	COG1595	DNA-templated transcription, initiation
KIV12_02745	COG1227	inorganic diphosphatase activity
KIV12_02750	COG4241	membrane
KIV12_02755	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KIV12_02760	COG0359	binds to the 23S rRNA
KIV12_02765	COG2807	transmembrane transport
KIV12_02770	COG3093	addiction module antidote protein HigA
KIV12_02775	COG2819	hydrolase of the alpha beta superfamily
KIV12_02780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KIV12_02785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KIV12_02785	COG2207	Transcriptional regulator
KIV12_02790	COG3251	PFAM MbtH domain protein
KIV12_02795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KIV12_02800	COG1535	isochorismatase
KIV12_02800	COG3433	isochorismatase activity
KIV12_02805	COG1021	2,3-dihydroxybenzoate-AMP ligase
KIV12_02810	COG1169	isochorismate synthase
KIV12_02815	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_02820	COG2819	hydrolase of the alpha beta superfamily
KIV12_02835	COG0305	Participates in initiation and elongation during chromosome replication
KIV12_02840	COG0346	lactoylglutathione lyase activity
KIV12_02845	COG2124	cytochrome p450
KIV12_02850	COG1309	transcriptional regulator
KIV12_02855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KIV12_02860	COG2311	Membrane
KIV12_02870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KIV12_02895	COG0745	RESPONSE REGULATOR receiver
KIV12_02900	COG5002	protein histidine kinase activity
KIV12_02905	COG4863	YycH protein
KIV12_02910	COG4853	Protein conserved in bacteria
KIV12_02915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KIV12_02920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIV12_02925	COG0456	acetyltransferase
KIV12_02945	COG4720	Psort location CytoplasmicMembrane, score
KIV12_02955	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KIV12_02965	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KIV12_03000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KIV12_03005	COG2409	Drug exporters of the RND superfamily
KIV12_03015	COG3850	Histidine kinase
KIV12_03015	COG5002	protein histidine kinase activity
KIV12_03030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KIV12_03050	COG0583	DNA-binding transcription factor activity
KIV12_03055	COG0384	phenazine biosynthesis protein PhzF
KIV12_03065	COG2188	Transcriptional regulator
KIV12_03075	COG2723	6-phospho-beta-galactosidase activity
KIV12_03100	COG5444	nuclease activity
KIV12_03115	COG2814	Major facilitator Superfamily
KIV12_03120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KIV12_03125	COG2814	Major facilitator Superfamily
KIV12_03130	COG1609	Transcriptional regulator
KIV12_03135	COG1113	amino acid transport
KIV12_03150	COG0494	nUDIX hydrolase
KIV12_03175	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KIV12_03175	COG2190	(PTS) system
KIV12_03175	COG1263	PTS System
KIV12_03180	COG2723	6-phospho-beta-galactosidase activity
KIV12_03185	COG3711	transcriptional antiterminator
KIV12_03190	COG0457	Tetratricopeptide repeat
KIV12_03195	COG1136	(ABC) transporter
KIV12_03205	COG2814	Major facilitator Superfamily
KIV12_03210	COG1309	transcriptional regulator
KIV12_03215	COG3835	regulator
KIV12_03220	COG2610	gluconate transmembrane transporter activity
KIV12_03225	COG1929	Belongs to the glycerate kinase type-1 family
KIV12_03230	COG2824	Alkylphosphonate utilization operon protein PhnA
KIV12_03235	COG1131	(ABC) transporter
KIV12_03240	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KIV12_03250	COG2851	Citrate transporter
KIV12_03255	COG1874	Beta-galactosidase
KIV12_03265	COG3833	ABC-type maltose transport systems, permease component
KIV12_03270	COG1175	transmembrane transport
KIV12_03275	COG2182	Extracellular solute-binding protein
KIV12_03280	COG1609	Transcriptional regulator
KIV12_03285	COG0583	DNA-binding transcription factor activity
KIV12_03290	COG3594	Acyltransferase
KIV12_03330	COG1737	Transcriptional regulator
KIV12_03335	COG1070	Carbohydrate kinase
KIV12_03345	COG4335	DNA alkylation repair
KIV12_03350	COG1113	amino acid transport
KIV12_03355	COG0840	transmembrane signaling receptor activity
KIV12_03360	COG0673	inositol 2-dehydrogenase activity
KIV12_03365	COG0789	Transcriptional regulator
KIV12_03370	COG0561	phosphatase activity
KIV12_03380	COG2226	methyltransferase
KIV12_03390	COG0477	Major facilitator Superfamily
KIV12_03395	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KIV12_03395	COG2755	lipolytic protein G-D-S-L family
KIV12_03405	COG2390	Transcriptional regulator
KIV12_03410	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KIV12_03415	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KIV12_03420	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KIV12_03425	COG1846	Transcriptional regulator
KIV12_03430	COG0778	Nitroreductase
KIV12_03435	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KIV12_03470	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KIV12_03475	COG4721	ABC-type cobalt transport system, permease component
KIV12_03480	COG1122	ATPase activity
KIV12_03485	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KIV12_03495	COG3878	Protein conserved in bacteria
KIV12_03500	COG3711	transcriptional antiterminator
KIV12_03505	COG2190	(PTS) system
KIV12_03505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KIV12_03505	COG1263	PTS System
KIV12_03510	COG2723	6-phospho-beta-galactosidase activity
KIV12_03530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KIV12_03535	COG2610	gluconate transmembrane transporter activity
KIV12_03545	COG2084	Dehydrogenase
KIV12_03550	COG1737	Transcriptional regulator
KIV12_03565	COG2195	Cleaves the N-terminal amino acid of tripeptides
KIV12_03570	COG4842	Belongs to the WXG100 family
KIV12_03595	COG1396	sequence-specific DNA binding
KIV12_03600	COG0252	asparaginase activity
KIV12_03605	COG1027	Aspartate ammonia-lyase
KIV12_03610	COG1757	Na H antiporter
KIV12_03635	COG3711	transcriptional antiterminator
KIV12_03635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KIV12_03640	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KIV12_03645	COG1312	Catalyzes the dehydration of D-mannonate
KIV12_03650	COG2723	6-phospho-beta-galactosidase activity
KIV12_03655	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KIV12_03660	COG1447	Phosphotransferase system cellobiose-specific component IIA
KIV12_03665	COG0726	polysaccharide deacetylase
KIV12_03675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KIV12_03675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KIV12_03680	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KIV12_03680	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KIV12_03685	COG2514	catechol 2,3-dioxygenase activity
KIV12_03690	COG1733	regulation of RNA biosynthetic process
KIV12_03695	COG5386	Cell surface protein
KIV12_03700	COG5386	Cell surface protein
KIV12_03725	COG4509	Sortase family
KIV12_03730	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KIV12_03735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KIV12_03745	COG1271	oxidase subunit
KIV12_03750	COG1294	oxidase, subunit
KIV12_03755	COG4988	ABC transporter
KIV12_03760	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KIV12_03770	COG1595	DNA-templated transcription, initiation
KIV12_03785	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KIV12_03800	COG3711	transcriptional antiterminator
KIV12_03800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KIV12_03805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KIV12_03810	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KIV12_03815	COG1447	Phosphotransferase system cellobiose-specific component IIA
KIV12_03820	COG1486	melibiose metabolic process
KIV12_03830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KIV12_03835	COG3420	alginic acid biosynthetic process
KIV12_03845	COG1129	ABC transporter
KIV12_03850	COG1172	Belongs to the binding-protein-dependent transport system permease family
KIV12_03855	COG2357	RelA SpoT domain protein
KIV12_03865	COG0457	Tetratricopeptide repeat
KIV12_03870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KIV12_03875	COG0765	amino acid transport
KIV12_03885	COG0346	lactoylglutathione lyase activity
KIV12_03890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KIV12_03895	COG1346	cytolysis
KIV12_03900	COG1380	Effector of murein hydrolase LrgA
KIV12_03905	COG0583	DNA-binding transcription factor activity
KIV12_03910	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KIV12_03915	COG0352	thiamine-phosphate diphosphorylase activity
KIV12_03930	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KIV12_03935	COG3162	membrane
KIV12_03945	COG4106	trans-aconitate 2-methyltransferase activity
KIV12_03955	COG2246	polysaccharide biosynthetic process
KIV12_03970	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KIV12_03975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KIV12_03980	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KIV12_03990	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KIV12_03995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KIV12_04000	COG1845	cytochrome c oxidase, subunit III
KIV12_04005	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KIV12_04015	COG0772	Belongs to the SEDS family
KIV12_04020	COG0778	Nitroreductase
KIV12_04025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KIV12_04035	COG1404	Belongs to the peptidase S8 family
KIV12_04045	COG3711	transcriptional antiterminator
KIV12_04050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KIV12_04050	COG1263	PTS System
KIV12_04055	COG1621	beta-fructofuranosidase activity
KIV12_04070	COG0351	phosphomethylpyrimidine kinase
KIV12_04080	COG1216	Glycosyl transferase, family 2
KIV12_04085	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KIV12_04090	COG1012	belongs to the aldehyde dehydrogenase family
KIV12_04100	COG2233	PERMEase
KIV12_04105	COG2363	Small membrane protein
KIV12_04125	COG0463	Glycosyl transferase, family 2
KIV12_04130	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KIV12_04135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KIV12_04140	COG0456	acetyltransferase
KIV12_04145	COG2089	acid synthase
KIV12_04150	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
KIV12_04155	COG3980	spore coat polysaccharide biosynthesis protein
KIV12_04160	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KIV12_04165	COG1088	dTDP-glucose 4,6-dehydratase activity
KIV12_04170	COG1091	dTDP-4-dehydrorhamnose reductase activity
KIV12_04175	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
KIV12_04180	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_04185	COG0436	Aminotransferase
KIV12_04190	COG0151	Belongs to the GarS family
KIV12_04195	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_04200	COG1917	Cupin 2, conserved barrel domain protein
KIV12_04205	COG0077	Prephenate dehydratase
KIV12_04210	COG2814	Major facilitator Superfamily
KIV12_04215	COG1522	sequence-specific DNA binding
KIV12_04220	COG2814	Major facilitator Superfamily
KIV12_04230	COG0280	phosphate acetyltransferase
KIV12_04245	COG5444	nuclease activity
KIV12_04295	COG4844	belongs to the
KIV12_04300	COG1078	dGTPase activity
KIV12_04305	COG3465	dGTPase activity
KIV12_04310	COG1126	abc transporter atp-binding protein
KIV12_04315	COG0765	amino acid transport
KIV12_04325	COG0765	amino acid transport
KIV12_04330	COG0454	-acetyltransferase
KIV12_04335	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KIV12_04340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KIV12_04345	COG0431	NADPH-dependent FMN reductase
KIV12_04350	COG0583	DNA-binding transcription factor activity
KIV12_04355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KIV12_04370	COG1942	4-Oxalocrotonate Tautomerase
KIV12_04375	COG1994	Peptidase M50
KIV12_04385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KIV12_04390	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KIV12_04395	COG0010	Belongs to the arginase family
KIV12_04405	COG4506	Protein conserved in bacteria
KIV12_04410	COG0018	arginyl-trna synthetase
KIV12_04415	COG1619	proteins homologs of microcin C7 resistance protein MccF
KIV12_04420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KIV12_04425	COG1132	(ABC) transporter
KIV12_04430	COG1619	proteins homologs of microcin C7 resistance protein MccF
KIV12_04440	COG4294	response to UV
KIV12_04445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KIV12_04450	COG0247	lactate metabolic process
KIV12_04450	COG2181	nitrate reductase activity
KIV12_04455	COG0183	Belongs to the thiolase family
KIV12_04460	COG1250	3-hydroxyacyl-CoA dehydrogenase
KIV12_04465	COG1960	acyl-CoA dehydrogenase activity
KIV12_04470	COG1960	acyl-CoA dehydrogenase activity
KIV12_04485	COG3343	RNA polymerase activity
KIV12_04490	COG0504	CTP synthase activity
KIV12_04495	COG4821	SIS domain
KIV12_04500	COG2204	response regulator
KIV12_04505	COG0191	fructose-bisphosphate aldolase activity
KIV12_04510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KIV12_04515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KIV12_04520	COG1494	fructose-1,6-bisphosphatase
KIV12_04525	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KIV12_04530	COG0254	rRNA binding
KIV12_04535	COG1435	thymidine kinase activity
KIV12_04540	COG0281	malic enzyme
KIV12_04545	COG0679	Auxin Efflux Carrier
KIV12_04550	COG0789	Transcriptional regulator
KIV12_04555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KIV12_04560	COG2890	protein-(glutamine-N5) methyltransferase activity
KIV12_04575	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KIV12_04580	COG0009	L-threonylcarbamoyladenylate synthase
KIV12_04585	COG1971	Probably functions as a manganese efflux pump
KIV12_04590	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KIV12_04595	COG0698	ribose 5-phosphate isomerase
KIV12_04600	COG4475	Protein of unknown function (DUF436)
KIV12_04605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KIV12_04610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KIV12_04620	COG0356	it plays a direct role in the translocation of protons across the membrane
KIV12_04625	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KIV12_04630	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KIV12_04635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KIV12_04640	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KIV12_04645	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
KIV12_04650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KIV12_04655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KIV12_04665	COG4836	Membrane
KIV12_04675	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KIV12_04680	COG2385	sporulation resulting in formation of a cellular spore
KIV12_04685	COG2304	oxidoreductase activity
KIV12_04690	COG2304	oxidoreductase activity
KIV12_04700	COG2223	nitrite transmembrane transporter activity
KIV12_04705	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KIV12_04710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KIV12_04715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KIV12_04720	COG0523	cobalamin synthesis protein
KIV12_04725	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KIV12_04760	COG1247	-acetyltransferase
KIV12_04765	COG0739	heme binding
KIV12_04770	COG0347	Belongs to the P(II) protein family
KIV12_04775	COG0004	ammonium transporteR
KIV12_04780	COG1126	abc transporter atp-binding protein
KIV12_04785	COG0765	amino acid transport
KIV12_04790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KIV12_04795	COG0477	Major facilitator Superfamily
KIV12_04800	COG0671	phosphoesterase, PA-phosphatase related
KIV12_04805	COG2814	Major facilitator Superfamily
KIV12_04810	COG1846	Transcriptional regulator
KIV12_04815	COG1609	Transcriptional regulator
KIV12_04820	COG1077	Cell shape determining protein MreB Mrl
KIV12_04825	COG4786	Flagellar basal body rod
KIV12_04830	COG4786	Flagellar basal body rod
KIV12_04835	COG0457	Tetratricopeptide repeat
KIV12_04840	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KIV12_04845	COG1970	mechanosensitive ion channel activity
KIV12_04860	COG0561	phosphatase activity
KIV12_04865	COG2202	Pas domain
KIV12_04865	COG1366	Belongs to the anti-sigma-factor antagonist family
KIV12_04870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KIV12_04875	COG4715	Zinc finger, swim domain protein
KIV12_04885	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KIV12_04890	COG2059	Chromate
KIV12_04895	COG2059	Chromate
KIV12_04900	COG1522	sequence-specific DNA binding
KIV12_04905	COG3527	Alpha-acetolactate decarboxylase
KIV12_04910	COG0028	Belongs to the TPP enzyme family
KIV12_04915	COG0583	DNA-binding transcription factor activity
KIV12_04920	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KIV12_04925	COG1879	ABC-type sugar transport system periplasmic component
KIV12_04930	COG1172	Belongs to the binding-protein-dependent transport system permease family
KIV12_04935	COG1129	ABC transporter
KIV12_04940	COG1869	D-ribose catabolic process
KIV12_04945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KIV12_04950	COG1609	Transcriptional regulator
KIV12_04965	COG0697	spore germination
KIV12_04970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KIV12_04980	COG2843	Capsule synthesis protein
KIV12_04990	COG0791	NLP P60 protein
KIV12_04995	COG0561	phosphatase activity
KIV12_05000	COG1316	TRANSCRIPTIONal
KIV12_05005	COG2814	Major facilitator Superfamily
KIV12_05020	COG0814	amino acid
KIV12_05025	COG0697	spore germination
KIV12_05030	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_05035	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
KIV12_05040	COG1609	Transcriptional regulator
KIV12_05045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KIV12_05050	COG0800	Aldolase
KIV12_05055	COG0454	-acetyltransferase
KIV12_05065	COG2972	Histidine kinase
KIV12_05070	COG2197	response regulator
KIV12_05075	COG1653	transport
KIV12_05080	COG1175	transmembrane transport
KIV12_05090	COG1482	cell wall glycoprotein biosynthetic process
KIV12_05095	COG4193	domain, Protein
KIV12_05100	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KIV12_05105	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KIV12_05110	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KIV12_05115	COG1682	transport, permease protein
KIV12_05120	COG1134	teichoic acid transport
KIV12_05125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KIV12_05130	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KIV12_05155	COG1316	TRANSCRIPTIONal
KIV12_05165	COG2247	cell wall binding repeat
KIV12_05165	COG2385	sporulation resulting in formation of a cellular spore
KIV12_05170	COG0860	N-Acetylmuramoyl-L-alanine amidase
KIV12_05170	COG2247	cell wall binding repeat
KIV12_05175	COG2247	cell wall binding repeat
KIV12_05175	COG0860	N-Acetylmuramoyl-L-alanine amidase
KIV12_05190	COG2244	polysaccharide biosynthetic process
KIV12_05195	COG0297	glycogen (starch) synthase activity
KIV12_05195	COG0438	transferase activity, transferring glycosyl groups
KIV12_05200	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KIV12_05205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KIV12_05210	COG3307	-O-antigen
KIV12_05215	COG3206	protein involved in exopolysaccharide biosynthesis
KIV12_05220	COG1215	transferase activity, transferring glycosyl groups
KIV12_05225	COG0438	transferase activity, transferring glycosyl groups
KIV12_05230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KIV12_05235	COG1316	TRANSCRIPTIONal
KIV12_05240	COG1739	Uncharacterized protein family UPF0029
KIV12_05245	COG4585	Histidine kinase
KIV12_05255	COG1307	EDD domain protein, DegV family
KIV12_05260	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KIV12_05270	COG1040	competence protein
KIV12_05285	COG3418	PFAM FlgN family protein
KIV12_05290	COG1256	bacterial-type flagellum assembly
KIV12_05290	COG4786	Flagellar basal body rod
KIV12_05295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KIV12_05305	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
KIV12_05310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KIV12_05315	COG1334	flagellar protein FlaG
KIV12_05320	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KIV12_05325	COG1516	flagellar protein fliS
KIV12_05340	COG0840	transmembrane signaling receptor activity
KIV12_05345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KIV12_05350	COG0653	protein targeting
KIV12_05370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KIV12_05375	COG2010	Cytochrome c
KIV12_05380	COG2884	Cell division ATP-binding protein ftsE
KIV12_05385	COG2177	Part of the ABC transporter FtsEX involved in
KIV12_05390	COG0791	NLP P60 protein
KIV12_05390	COG3883	PFAM NLP P60 protein
KIV12_05395	COG0730	response to heat
KIV12_05400	COG0793	Belongs to the peptidase S41A family
KIV12_05400	COG3409	Peptidoglycan-binding domain 1 protein
KIV12_05410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIV12_05415	COG1733	regulation of RNA biosynthetic process
KIV12_05420	COG0778	Nitroreductase
KIV12_05425	COG1113	amino acid transport
KIV12_05430	COG0463	Glycosyl transferase, family 2
KIV12_05435	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KIV12_05440	COG5002	protein histidine kinase activity
KIV12_05445	COG0745	RESPONSE REGULATOR receiver
KIV12_05455	COG2814	Major facilitator Superfamily
KIV12_05460	COG1309	transcriptional regulator
KIV12_05465	COG0574	Belongs to the PEP-utilizing enzyme family
KIV12_05465	COG3848	Pyruvate phosphate dikinase
KIV12_05470	COG4897	Protein conserved in bacteria
KIV12_05480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KIV12_05495	COG3595	metallopeptidase activity
KIV12_05500	COG1983	PspC domain protein
KIV12_05505	COG1950	PFAM Membrane protein of
KIV12_05510	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KIV12_05515	COG2188	Transcriptional regulator
KIV12_05520	COG0363	glucosamine-6-phosphate deaminase activity
KIV12_05525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KIV12_05530	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
KIV12_05535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KIV12_05540	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KIV12_05545	COG0546	phosphoglycolate phosphatase activity
KIV12_05550	COG0110	maltose O-acetyltransferase activity
KIV12_05555	COG1959	2 iron, 2 sulfur cluster binding
KIV12_05560	COG2910	NAD(P)H-binding
KIV12_05570	COG4990	cell redox homeostasis
KIV12_05575	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KIV12_05580	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KIV12_05585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KIV12_05590	COG0131	Imidazoleglycerol-phosphate dehydratase
KIV12_05595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KIV12_05600	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KIV12_05605	COG0107	imidazoleglycerol-phosphate synthase activity
KIV12_05610	COG0140	phosphoribosyl-ATP diphosphatase activity
KIV12_05610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KIV12_05615	COG0457	Tetratricopeptide repeat
KIV12_05620	COG3883	PFAM NLP P60 protein
KIV12_05620	COG0791	NLP P60 protein
KIV12_05625	COG0492	ferredoxin-NADP+ reductase activity
KIV12_05630	COG1051	belongs to the nudix hydrolase family
KIV12_05635	COG1660	Displays ATPase and GTPase activities
KIV12_05640	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KIV12_05645	COG1481	regulation of sporulation
KIV12_05650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KIV12_05655	COG2162	N-hydroxyarylamine O-acetyltransferase activity
KIV12_05665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KIV12_05670	COG0288	reversible hydration of carbon dioxide
KIV12_05675	COG0659	secondary active sulfate transmembrane transporter activity
KIV12_05680	COG1694	Mazg nucleotide pyrophosphohydrolase
KIV12_05685	COG1611	Belongs to the LOG family
KIV12_05690	COG0740	serine-type endopeptidase activity
KIV12_05730	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KIV12_05735	COG1819	glycosyl
KIV12_05740	COG0488	(ABC) transporter
KIV12_05745	COG0726	polysaccharide deacetylase
KIV12_05750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KIV12_05755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KIV12_05760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KIV12_05770	COG1396	sequence-specific DNA binding
KIV12_05775	COG3944	biosynthesis protein
KIV12_05780	COG0489	protein tyrosine kinase activity
KIV12_05785	COG1086	Polysaccharide biosynthesis protein
KIV12_05790	COG0438	transferase activity, transferring glycosyl groups
KIV12_05795	COG1215	transferase activity, transferring glycosyl groups
KIV12_05800	COG0438	transferase activity, transferring glycosyl groups
KIV12_05810	COG1216	Glycosyl transferase, family 2
KIV12_05815	COG5039	Polysaccharide pyruvyl transferase
KIV12_05820	COG2244	polysaccharide biosynthetic process
KIV12_05825	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KIV12_05830	COG0110	maltose O-acetyltransferase activity
KIV12_05835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KIV12_05840	COG0747	negative chemotaxis
KIV12_05845	COG0601	transmembrane transport
KIV12_05850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIV12_05855	COG0444	Belongs to the ABC transporter superfamily
KIV12_05860	COG4608	Belongs to the ABC transporter superfamily
KIV12_05865	COG0534	Mate efflux family protein
KIV12_05875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KIV12_05880	COG2186	Transcriptional regulator
KIV12_05885	COG3829	transcription factor binding
KIV12_05890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KIV12_05895	COG0833	amino acid
KIV12_05900	COG2390	Transcriptional regulator
KIV12_05905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KIV12_05910	COG0126	phosphoglycerate kinase activity
KIV12_05915	COG0149	triose-phosphate isomerase activity
KIV12_05920	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KIV12_05925	COG0148	phosphopyruvate hydratase activity
KIV12_05935	COG1131	(ABC) transporter
KIV12_05955	COG0456	acetyltransferase
KIV12_05965	COG2095	MarC family integral membrane protein
KIV12_05970	COG1510	regulation of RNA biosynthetic process
KIV12_05975	COG1125	glycine betaine transport
KIV12_05975	COG0517	IMP dehydrogenase activity
KIV12_05980	COG1174	glycine betaine transport
KIV12_05985	COG1732	Glycine betaine
KIV12_05990	COG1174	glycine betaine transport
KIV12_05995	COG1733	regulation of RNA biosynthetic process
KIV12_06000	COG1396	sequence-specific DNA binding
KIV12_06005	COG1396	sequence-specific DNA binding
KIV12_06010	COG1476	TRANSCRIPTIONal
KIV12_06015	COG2002	toxin-antitoxin pair type II binding
KIV12_06020	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KIV12_06025	COG1647	Serine aminopeptidase, S33
KIV12_06030	COG0557	exoribonuclease II activity
KIV12_06035	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KIV12_06065	COG1937	Protein conserved in bacteria
KIV12_06070	COG2608	mercury ion transmembrane transporter activity
KIV12_06075	COG2217	Heavy metal translocating P-type atpase
KIV12_06090	COG1027	Aspartate ammonia-lyase
KIV12_06095	COG4191	Histidine kinase
KIV12_06100	COG0784	Response regulator, receiver
KIV12_06105	COG3226	Transcriptional regulator
KIV12_06115	COG0803	Belongs to the bacterial solute-binding protein 9 family
KIV12_06120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KIV12_06125	COG1121	(ABC) transporter
KIV12_06130	COG2217	Heavy metal translocating P-type atpase
KIV12_06135	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KIV12_06140	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KIV12_06145	COG2860	membrane
KIV12_06150	COG0025	NhaP-type Na H and K H
KIV12_06155	COG1940	carbohydrate kinase activity
KIV12_06160	COG0656	L-ascorbic acid biosynthetic process
KIV12_06165	COG4149	molybdate abc transporter
KIV12_06170	COG0725	ABC transporter, periplasmic molybdate-binding protein
KIV12_06175	COG1368	sulfuric ester hydrolase activity
KIV12_06180	COG1988	membrane-bound metal-dependent
KIV12_06195	COG0531	amino acid
KIV12_06200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KIV12_06205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KIV12_06210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KIV12_06215	COG1120	ATPase activity
KIV12_06220	COG0745	RESPONSE REGULATOR receiver
KIV12_06225	COG2205	protein histidine kinase activity
KIV12_06230	COG1904	glucuronate isomerase
KIV12_06235	COG1609	Transcriptional regulator
KIV12_06240	COG0246	Mannitol dehydrogenase
KIV12_06245	COG2721	sulfolactate sulfo-lyase activity
KIV12_06255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KIV12_06260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KIV12_06265	COG1120	ATPase activity
KIV12_06270	COG2096	Adenosyltransferase
KIV12_06275	COG4758	membrane
KIV12_06280	COG1842	Phage shock protein A
KIV12_06290	COG4758	membrane
KIV12_06295	COG4585	Histidine kinase
KIV12_06300	COG2197	response regulator
KIV12_06315	COG0814	amino acid
KIV12_06320	COG0697	spore germination
KIV12_06330	COG0114	fumarate hydratase activity
KIV12_06335	COG1309	transcriptional regulator
KIV12_06345	COG2770	Histidine kinase
KIV12_06345	COG2205	protein histidine kinase activity
KIV12_06350	COG0745	RESPONSE REGULATOR receiver
KIV12_06355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIV12_06360	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_06370	COG1120	ATPase activity
KIV12_06380	COG5577	PFAM Coat F domain
KIV12_06395	COG1024	Enoyl-CoA hydratase
KIV12_06395	COG1250	3-hydroxyacyl-CoA dehydrogenase
KIV12_06400	COG0183	Belongs to the thiolase family
KIV12_06405	COG1960	acyl-CoA dehydrogenase activity
KIV12_06410	COG1393	Belongs to the ArsC family
KIV12_06415	COG0509	glycine decarboxylation via glycine cleavage system
KIV12_06425	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KIV12_06430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIV12_06440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KIV12_06445	COG2011	ABC-type metal ion transport system permease component
KIV12_06450	COG1464	Belongs to the NlpA lipoprotein family
KIV12_06455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KIV12_06465	COG0396	ATPase activity
KIV12_06470	COG0719	Fe-S assembly protein
KIV12_06475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KIV12_06480	COG0822	iron-sulfur transferase activity
KIV12_06485	COG0719	Fe-S assembly protein
KIV12_06490	COG1309	transcriptional regulator
KIV12_06495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KIV12_06500	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KIV12_06510	COG2311	Membrane
KIV12_06515	COG0745	RESPONSE REGULATOR receiver
KIV12_06520	COG5002	protein histidine kinase activity
KIV12_06520	COG0642	Histidine kinase
KIV12_06530	COG0561	phosphatase activity
KIV12_06545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KIV12_06550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KIV12_06555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KIV12_06570	COG2356	endonuclease I
KIV12_06575	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KIV12_06580	COG2814	Major facilitator Superfamily
KIV12_06585	COG2140	Oxalate decarboxylase
KIV12_06590	COG2508	Transcriptional regulator
KIV12_06595	COG1801	Protein of unknown function DUF72
KIV12_06600	COG0737	Belongs to the 5'-nucleotidase family
KIV12_06605	COG3377	Domain of unknown function (DUF1805)
KIV12_06625	COG0739	heme binding
KIV12_06630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KIV12_06640	COG4470	Protein conserved in bacteria
KIV12_06645	COG2445	Protein of unknown function DUF86
KIV12_06650	COG0647	UMP catabolic process
KIV12_06655	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KIV12_06660	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KIV12_06665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KIV12_06670	COG0460	homoserine dehydrogenase
KIV12_06675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KIV12_06680	COG0083	homoserine kinase activity
KIV12_06685	COG0823	Involved in the tonB-independent uptake of proteins
KIV12_06685	COG1506	peptidase
KIV12_06685	COG4946	Tricorn protease homolog
KIV12_06690	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KIV12_06695	COG4837	Protein of unknown function (DUF1462)
KIV12_06705	COG1252	NADH dehydrogenase
KIV12_06710	COG4844	belongs to the
KIV12_06715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KIV12_06720	COG0316	Belongs to the HesB IscA family
KIV12_06725	COG5504	Zn-dependent protease
KIV12_06730	COG0789	Transcriptional regulator
KIV12_06745	COG0492	ferredoxin-NADP+ reductase activity
KIV12_06750	COG1252	NADH dehydrogenase
KIV12_06765	COG3584	3D domain protein
KIV12_06770	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KIV12_06775	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KIV12_06780	COG2056	Na+-H+ antiporter family
KIV12_06785	COG1268	BioY protein
KIV12_06790	COG0686	Belongs to the AlaDH PNT family
KIV12_06795	COG2508	Transcriptional regulator
KIV12_06795	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KIV12_06800	COG4842	Belongs to the WXG100 family
KIV12_06805	COG5417	Belongs to the EsaB family
KIV12_06810	COG4499	WXG100 protein secretion system (Wss), protein YukC
KIV12_06815	COG0433	COG0433 Predicted ATPase
KIV12_06815	COG1674	ftsk spoiiie
KIV12_06820	COG1511	domain protein
KIV12_06830	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_06835	COG1418	mRNA catabolic process
KIV12_06850	COG0628	permease
KIV12_06870	COG5506	Protein of unknown function (DUF1694)
KIV12_06875	COG1335	isochorismatase
KIV12_06880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KIV12_06885	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KIV12_06900	COG0142	geranyltranstransferase activity
KIV12_06910	COG4585	Histidine kinase
KIV12_06915	COG2197	response regulator
KIV12_06920	COG2050	protein possibly involved in aromatic compounds catabolism
KIV12_06925	COG1320	monovalent cation:proton antiporter activity
KIV12_06930	COG2212	antiporter activity
KIV12_06935	COG1863	multisubunit Na H antiporter MnhE subunit
KIV12_06940	COG0651	ATP synthesis coupled electron transport
KIV12_06945	COG1006	Multisubunit Na H antiporter MnhC subunit
KIV12_06950	COG2111	Na H antiporter
KIV12_06955	COG2111	Na H antiporter
KIV12_06955	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KIV12_06965	COG3493	citrate carrier protein
KIV12_06970	COG1079	Belongs to the binding-protein-dependent transport system permease family
KIV12_06975	COG4603	Belongs to the binding-protein-dependent transport system permease family
KIV12_06980	COG3845	ABC transporter
KIV12_06985	COG1744	ABC transporter substrate-binding protein PnrA-like
KIV12_06990	COG4565	transcriptional regulatory protein
KIV12_06995	COG3290	protein histidine kinase activity
KIV12_07005	COG3011	Protein conserved in bacteria
KIV12_07010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KIV12_07015	COG2814	Major facilitator Superfamily
KIV12_07020	COG5018	Exonuclease
KIV12_07035	COG2205	protein histidine kinase activity
KIV12_07040	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KIV12_07050	COG2267	carboxylic ester hydrolase activity
KIV12_07055	COG1522	sequence-specific DNA binding
KIV12_07060	COG0436	Aminotransferase
KIV12_07065	COG1098	S1 RNA binding domain
KIV12_07070	COG2155	Conserved Protein
KIV12_07075	COG1979	alcohol dehydrogenase
KIV12_07080	COG1979	alcohol dehydrogenase
KIV12_07085	COG0166	Belongs to the GPI family
KIV12_07100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KIV12_07110	COG2738	Putative neutral zinc metallopeptidase
KIV12_07115	COG1253	flavin adenine dinucleotide binding
KIV12_07120	COG0432	Pfam Uncharacterised protein family UPF0047
KIV12_07125	COG2070	2-Nitropropane dioxygenase
KIV12_07140	COG0840	transmembrane signaling receptor activity
KIV12_07145	COG0840	transmembrane signaling receptor activity
KIV12_07150	COG0840	transmembrane signaling receptor activity
KIV12_07155	COG0840	transmembrane signaling receptor activity
KIV12_07160	COG0693	protein deglycase activity
KIV12_07165	COG0673	inositol 2-dehydrogenase activity
KIV12_07175	COG0628	permease
KIV12_07190	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KIV12_07200	COG1396	sequence-specific DNA binding
KIV12_07220	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
KIV12_07230	COG1595	DNA-templated transcription, initiation
KIV12_07235	COG5484	DNA packaging
KIV12_07240	COG1783	phage Terminase large subunit
KIV12_07245	COG5518	Phage portal protein
KIV12_07250	COG0338	D12 class N6 adenine-specific DNA methyltransferase
KIV12_07255	COG4653	Phage capsid family
KIV12_07310	COG3953	SLT domain
KIV12_07310	COG5280	Phage tail tape measure protein TP901
KIV12_07310	COG3953	SLT domain
KIV12_07310	COG5280	Phage tail tape measure protein TP901
KIV12_07315	COG1652	LysM domain
KIV12_07320	COG4193	domain, Protein
KIV12_07330	COG3628	GPW Gp25 family protein
KIV12_07335	COG3299	homolog of phage Mu protein gp47
KIV12_07340	COG3778	Protein conserved in bacteria
KIV12_07375	COG3409	Peptidoglycan-binding domain 1 protein
KIV12_07375	COG5632	N-Acetylmuramoyl-L-alanine amidase
KIV12_07390	COG1510	regulation of RNA biosynthetic process
KIV12_07395	COG1012	belongs to the aldehyde dehydrogenase family
KIV12_07400	COG1454	alcohol dehydrogenase
KIV12_07405	COG2318	DinB family
KIV12_07410	COG1585	Membrane protein implicated in regulation of membrane protease activity
KIV12_07415	COG2268	Band 7 protein
KIV12_07420	COG0772	Belongs to the SEDS family
KIV12_07425	COG0772	Belongs to the SEDS family
KIV12_07430	COG3339	Conserved Protein
KIV12_07435	COG1247	-acetyltransferase
KIV12_07440	COG3859	Proton-coupled thiamine transporter YuaJ
KIV12_07565	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
KIV12_07570	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KIV12_07575	COG1575	Belongs to the MenA family. Type 1 subfamily
KIV12_07580	COG1169	isochorismate synthase
KIV12_07585	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
KIV12_07590	COG0596	Alpha beta hydrolase
KIV12_07595	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KIV12_07600	COG0318	PFAM AMP-dependent synthetase and ligase
KIV12_07605	COG4948	Mandelate Racemase Muconate Lactonizing
KIV12_07620	COG1294	oxidase, subunit
KIV12_07625	COG1271	oxidase subunit
KIV12_07635	COG3443	Belongs to the bacterial solute-binding protein 9 family
KIV12_07635	COG0803	Belongs to the bacterial solute-binding protein 9 family
KIV12_07640	COG0288	reversible hydration of carbon dioxide
KIV12_07645	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KIV12_07650	COG1854	S-ribosylhomocysteine lyase activity
KIV12_07665	COG0783	Belongs to the Dps family
KIV12_07675	COG4824	toxin secretion phage lysis holin
KIV12_07695	COG0494	nUDIX hydrolase
KIV12_07700	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KIV12_07705	COG1116	anion transmembrane transporter activity
KIV12_07710	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KIV12_07730	COG1233	COG1233 Phytoene dehydrogenase and related
KIV12_07735	COG1506	peptidase
KIV12_07745	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KIV12_07750	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KIV12_07755	COG0367	asparagine synthase
KIV12_07760	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KIV12_07765	COG2267	carboxylic ester hydrolase activity
KIV12_07775	COG4326	sporulation control protein
KIV12_07780	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KIV12_07785	COG1242	4 iron, 4 sulfur cluster binding
KIV12_07805	COG1725	Transcriptional regulator
KIV12_07810	COG1131	(ABC) transporter
KIV12_07820	COG1136	(ABC) transporter
KIV12_07825	COG0577	efflux transmembrane transporter activity
KIV12_07830	COG2433	Pfam Transposase IS66
KIV12_07835	COG2202	Pas domain
KIV12_07835	COG1366	Belongs to the anti-sigma-factor antagonist family
KIV12_07845	COG0495	leucyl-tRNA aminoacylation
KIV12_07850	COG1073	alpha beta
KIV12_07855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KIV12_07860	COG0395	ABC-type sugar transport system, permease component
KIV12_07865	COG1653	transport
KIV12_07870	COG0656	L-ascorbic acid biosynthetic process
KIV12_07875	COG2814	Major facilitator Superfamily
KIV12_07880	COG1733	regulation of RNA biosynthetic process
KIV12_07885	COG2207	Transcriptional regulator
KIV12_07890	COG4209	transmembrane transport
KIV12_07895	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
KIV12_07900	COG1653	transport
KIV12_07905	COG0673	inositol 2-dehydrogenase activity
KIV12_07910	COG5578	integral membrane protein
KIV12_07915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KIV12_07925	COG3196	Protein conserved in bacteria
KIV12_07930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KIV12_07940	COG2081	HI0933 family
KIV12_07945	COG2244	polysaccharide biosynthetic process
KIV12_07950	COG1187	pseudouridine synthase activity
KIV12_07955	COG1349	DNA-binding transcription factor activity
KIV12_07960	COG2252	PERMEase
KIV12_07965	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KIV12_07970	COG3340	Belongs to the peptidase S51 family
KIV12_07975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KIV12_07980	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KIV12_07990	COG1597	lipid kinase activity
KIV12_07995	COG0510	thiamine kinase activity
KIV12_08005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KIV12_08010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KIV12_08015	COG0281	malic enzyme
KIV12_08020	COG5584	Small secreted protein
KIV12_08025	COG1363	Peptidase, m42
KIV12_08040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIV12_08045	COG4848	Belongs to the UPF0354 family
KIV12_08050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KIV12_08055	COG1674	ftsk spoiiie
KIV12_08060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KIV12_08065	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
KIV12_08070	COG4980	gas vesicle protein
KIV12_08075	COG3118	belongs to the thioredoxin family
KIV12_08080	COG1605	Chorismate mutase
KIV12_08080	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KIV12_08085	COG1609	Transcriptional regulator
KIV12_08090	COG0123	including yeast histone deacetylase and acetoin utilization protein
KIV12_08095	COG0517	IMP dehydrogenase activity
KIV12_08100	COG0454	-acetyltransferase
KIV12_08105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KIV12_08110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KIV12_08115	COG2329	Antibiotic biosynthesis monooxygenase
KIV12_08120	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KIV12_08130	COG1335	isochorismatase
KIV12_08140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KIV12_08145	COG1956	GAF domain-containing protein
KIV12_08150	COG1309	transcriptional regulator
KIV12_08155	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KIV12_08160	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
KIV12_08165	COG1114	Component of the transport system for branched-chain amino acids
KIV12_08170	COG1114	Component of the transport system for branched-chain amino acids
KIV12_08175	COG1104	cysteine desulfurase activity
KIV12_08180	COG0301	tRNA thio-modification
KIV12_08190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KIV12_08195	COG1279	arginine transmembrane transporter activity
KIV12_08215	COG2249	NAD(P)H dehydrogenase (quinone) activity
KIV12_08220	COG0402	S-adenosylhomocysteine deaminase activity
KIV12_08225	COG0577	efflux transmembrane transporter activity
KIV12_08230	COG1136	(ABC) transporter
KIV12_08235	COG2205	protein histidine kinase activity
KIV12_08240	COG0745	RESPONSE REGULATOR receiver
KIV12_08245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KIV12_08250	COG2197	response regulator
KIV12_08255	COG4585	Histidine kinase
KIV12_08260	COG3239	Fatty acid desaturase
KIV12_08270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KIV12_08275	COG0616	signal peptide processing
KIV12_08280	COG1714	RDD family
KIV12_08290	COG3874	Sporulation protein YtfJ
KIV12_08295	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KIV12_08300	COG0827	DNA restriction-modification system
KIV12_08305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KIV12_08310	COG0521	Mo-molybdopterin cofactor biosynthetic process
KIV12_08315	COG0137	argininosuccinate synthase activity
KIV12_08320	COG0165	Argininosuccinate lyase
KIV12_08330	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_08335	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KIV12_08340	COG4109	DRTGG domain
KIV12_08350	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KIV12_08370	COG0587	DNA-directed DNA polymerase activity
KIV12_08375	COG0281	malic enzyme
KIV12_08380	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KIV12_08385	COG0825	malonyl-CoA metabolic process
KIV12_08390	COG0205	6-phosphofructokinase activity
KIV12_08400	COG3030	protein affecting phage T7 exclusion by the F plasmid
KIV12_08405	COG0628	permease
KIV12_08410	COG2707	UPF0756 membrane protein
KIV12_08415	COG0372	Belongs to the citrate synthase family
KIV12_08420	COG0538	isocitrate dehydrogenase activity
KIV12_08425	COG0039	L-malate dehydrogenase activity
KIV12_08430	COG0745	RESPONSE REGULATOR receiver
KIV12_08435	COG5002	protein histidine kinase activity
KIV12_08440	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KIV12_08440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KIV12_08445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KIV12_08450	COG1971	Probably functions as a manganese efflux pump
KIV12_08455	COG0237	dephospho-CoA kinase activity
KIV12_08460	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KIV12_08465	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KIV12_08475	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KIV12_08480	COG3611	Membrane attachment protein
KIV12_08485	COG1484	DNA-dependent DNA replication
KIV12_08490	COG0398	Pfam SNARE associated Golgi protein
KIV12_08500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KIV12_08510	COG1011	Hydrolase
KIV12_08515	COG3275	phosphorelay sensor kinase activity
KIV12_08520	COG3279	Response regulator of the LytR AlgR family
KIV12_08530	COG1346	cytolysis
KIV12_08535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KIV12_08540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KIV12_08545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KIV12_08550	COG3326	Membrane
KIV12_08560	COG1363	Peptidase, m42
KIV12_08565	COG1966	Carbon starvation protein
KIV12_08575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KIV12_08580	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KIV12_08585	COG0072	phenylalanine-tRNA ligase activity
KIV12_08585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KIV12_08590	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KIV12_08595	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KIV12_08600	COG1286	toxin biosynthetic process
KIV12_08605	COG1796	DNA polymerase
KIV12_08605	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KIV12_08610	COG1193	negative regulation of DNA recombination
KIV12_08615	COG3766	membrane
KIV12_08625	COG0318	PFAM AMP-dependent synthetase and ligase
KIV12_08630	COG1309	transcriptional regulator
KIV12_08635	COG1024	Enoyl-CoA hydratase
KIV12_08640	COG2086	electron transfer activity
KIV12_08645	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KIV12_08650	COG3534	alpha-L-arabinofuranosidase
KIV12_08655	COG3118	belongs to the thioredoxin family
KIV12_08660	COG0322	excinuclease ABC activity
KIV12_08665	COG0527	aspartate kinase activity
KIV12_08675	COG0601	transmembrane transport
KIV12_08680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIV12_08690	COG1719	4-vinyl reductase, 4VR
KIV12_08695	COG2009	succinate dehydrogenase
KIV12_08700	COG1053	succinate dehydrogenase
KIV12_08705	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KIV12_08710	COG0824	Thioesterase
KIV12_08720	COG2828	Protein conserved in bacteria
KIV12_08725	COG0583	DNA-binding transcription factor activity
KIV12_08730	COG2851	Citrate transporter
KIV12_08735	COG2197	response regulator
KIV12_08740	COG1846	Transcriptional regulator
KIV12_08745	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KIV12_08750	COG5401	PFAM Sporulation and spore germination
KIV12_08755	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
KIV12_08760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KIV12_08765	COG0622	Phosphoesterase
KIV12_08810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KIV12_08815	COG1696	Membrane protein involved in D-alanine export
KIV12_08820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KIV12_08825	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KIV12_08830	COG3339	Conserved Protein
KIV12_08835	COG2706	6-phosphogluconolactonase activity
KIV12_08840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KIV12_08845	COG0028	Belongs to the TPP enzyme family
KIV12_08850	COG0440	acetolactate synthase activity
KIV12_08855	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KIV12_08860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KIV12_08865	COG0473	3-isopropylmalate dehydrogenase activity
KIV12_08870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KIV12_08875	COG0066	3-isopropylmalate dehydratase activity
KIV12_08880	COG1477	protein flavinylation
KIV12_08880	COG0457	Tetratricopeptide repeat
KIV12_08885	COG0544	peptidyl-prolyl cis-trans isomerase activity
KIV12_08890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KIV12_08895	COG0470	DNA polymerase III
KIV12_08895	COG1067	ATP-dependent peptidase activity
KIV12_08900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KIV12_08905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KIV12_08915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KIV12_08920	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KIV12_08925	COG0181	hydroxymethylbilane synthase activity
KIV12_08930	COG1587	Uroporphyrinogen-III synthase
KIV12_08935	COG0113	porphobilinogen synthase activity
KIV12_08940	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KIV12_08945	COG1388	LysM domain
KIV12_08950	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KIV12_08960	COG0525	valine-tRNA ligase activity
KIV12_08965	COG0285	dihydrofolate synthase activity
KIV12_08970	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KIV12_08980	COG0424	maF-like protein
KIV12_08985	COG2003	Belongs to the UPF0758 family
KIV12_08990	COG1077	Cell shape determining protein MreB Mrl
KIV12_09000	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KIV12_09005	COG0850	regulation of cytokinetic process
KIV12_09010	COG2894	cell division
KIV12_09015	COG0739	heme binding
KIV12_09020	COG1994	Peptidase M50
KIV12_09025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KIV12_09030	COG2868	ribosomal protein
KIV12_09035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KIV12_09040	COG3290	protein histidine kinase activity
KIV12_09045	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KIV12_09050	COG4492	Belongs to the UPF0735 family
KIV12_09055	COG0077	Prephenate dehydratase
KIV12_09060	COG1827	regulation of RNA biosynthetic process
KIV12_09065	COG1104	cysteine desulfurase activity
KIV12_09070	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KIV12_09075	COG0157	Belongs to the NadC ModD family
KIV12_09080	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KIV12_09085	COG1388	LysM domain
KIV12_09100	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KIV12_09115	COG2112	serine threonine protein kinase
KIV12_09125	COG0632	four-way junction helicase activity
KIV12_09130	COG2255	four-way junction helicase activity
KIV12_09140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KIV12_09145	COG0343	queuine tRNA-ribosyltransferase activity
KIV12_09150	COG1862	Preprotein translocase
KIV12_09160	COG2323	membrane
KIV12_09165	COG2244	polysaccharide biosynthetic process
KIV12_09175	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KIV12_09175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KIV12_09180	COG0490	domain, Protein
KIV12_09185	COG5416	Lipopolysaccharide assembly protein A domain
KIV12_09190	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KIV12_09190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KIV12_09195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KIV12_09200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KIV12_09205	COG1490	D-aminoacyl-tRNA deacylase activity
KIV12_09210	COG0860	N-Acetylmuramoyl-L-alanine amidase
KIV12_09210	COG3103	Sh3 type 3 domain protein
KIV12_09210	COG4991	sh3 domain protein
KIV12_09220	COG0124	histidyl-tRNA synthetase
KIV12_09235	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KIV12_09240	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KIV12_09245	COG1959	2 iron, 2 sulfur cluster binding
KIV12_09250	COG1104	cysteine desulfurase activity
KIV12_09255	COG0482	sulfurtransferase activity
KIV12_09260	COG0457	Tetratricopeptide repeat
KIV12_09265	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KIV12_09270	COG3881	PFAM PRC-barrel domain
KIV12_09285	COG0765	amino acid transport
KIV12_09290	COG0765	amino acid transport
KIV12_09295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KIV12_09300	COG1126	abc transporter atp-binding protein
KIV12_09305	COG0628	permease
KIV12_09310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KIV12_09315	COG4472	Bacterial protein of unknown function (DUF965)
KIV12_09320	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KIV12_09325	COG3906	Belongs to the UPF0473 family
KIV12_09330	COG1268	BioY protein
KIV12_09335	COG0318	PFAM AMP-dependent synthetase and ligase
KIV12_09340	COG0183	Belongs to the thiolase family
KIV12_09345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KIV12_09350	COG4122	O-methyltransferase activity
KIV12_09355	COG0826	peptidase U32
KIV12_09360	COG0826	peptidase U32
KIV12_09365	COG0572	uridine kinase
KIV12_09370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KIV12_09375	COG0768	penicillin binding
KIV12_09390	COG2226	methyltransferase
KIV12_09395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KIV12_09400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KIV12_09405	COG0626	cystathionine gamma-synthase activity
KIV12_09430	COG2226	methyltransferase
KIV12_09435	COG1063	alcohol dehydrogenase
KIV12_09445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KIV12_09450	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_09475	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KIV12_09480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KIV12_09495	COG1088	dTDP-glucose 4,6-dehydratase activity
KIV12_09500	COG1091	dTDP-4-dehydrorhamnose reductase activity
KIV12_09505	COG1131	(ABC) transporter
KIV12_09510	COG0842	Transport permease protein
KIV12_09510	COG1511	domain protein
KIV12_09515	COG0842	Transport permease protein
KIV12_09530	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_09540	COG1063	alcohol dehydrogenase
KIV12_09545	COG3546	catalase activity
KIV12_09555	COG0765	amino acid transport
KIV12_09560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KIV12_09565	COG1126	abc transporter atp-binding protein
KIV12_09570	COG1960	acyl-CoA dehydrogenase activity
KIV12_09575	COG2602	Beta-lactamase
KIV12_09580	COG3209	COG3209 Rhs family protein
KIV12_09600	COG0657	acetylesterase activity
KIV12_09605	COG1733	regulation of RNA biosynthetic process
KIV12_09610	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KIV12_09615	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KIV12_09625	COG1846	Transcriptional regulator
KIV12_09650	COG2160	L-arabinose isomerase activity
KIV12_09675	COG1131	(ABC) transporter
KIV12_09710	COG0726	polysaccharide deacetylase
KIV12_09730	COG3959	Transketolase, thiamine diphosphate binding domain
KIV12_09735	COG3958	Transketolase
KIV12_09740	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_09755	COG2186	Transcriptional regulator
KIV12_09765	COG0457	Tetratricopeptide repeat
KIV12_09775	COG2755	lipolytic protein G-D-S-L family
KIV12_09790	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KIV12_09795	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KIV12_09800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KIV12_09805	COG1534	Rna-binding protein
KIV12_09810	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KIV12_09815	COG1713	HD superfamily hydrolase involved in NAD metabolism
KIV12_09820	COG0799	negative regulation of ribosome biogenesis
KIV12_09825	COG2226	methyltransferase
KIV12_09830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KIV12_09835	COG1555	photosystem II stabilization
KIV12_09835	COG1596	polysaccharide export
KIV12_09840	COG2131	deaminase
KIV12_09845	COG0658	competence protein
KIV12_09845	COG2333	competence protein COMEC
KIV12_09855	COG1466	dna polymerase III delta subunit
KIV12_09860	COG0268	Binds directly to 16S ribosomal RNA
KIV12_09865	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
KIV12_09870	COG0860	N-Acetylmuramoyl-L-alanine amidase
KIV12_09880	COG0481	GTPase activity
KIV12_09885	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KIV12_09890	COG1420	regulation of RNA biosynthetic process
KIV12_09895	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KIV12_09900	COG0443	Heat shock 70 kDa protein
KIV12_09905	COG0484	heat shock protein binding
KIV12_09910	COG2264	protein methyltransferase activity
KIV12_09915	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KIV12_09920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KIV12_09925	COG1283	sodium-dependent phosphate transmembrane transporter activity
KIV12_09935	COG1610	YqeY-like protein
KIV12_09940	COG1030	water channel activity
KIV12_09945	COG4864	UPF0365 protein
KIV12_09960	COG0561	phosphatase activity
KIV12_09965	COG1702	phosphate starvation-inducible protein PhoH
KIV12_09970	COG1480	7TM receptor with intracellular HD hydrolase
KIV12_09975	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KIV12_09980	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KIV12_09985	COG0295	cytidine deaminase activity
KIV12_09990	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KIV12_10000	COG1381	Involved in DNA repair and RecF pathway recombination
KIV12_10005	COG0752	glycyl-tRNA synthetase alpha subunit
KIV12_10010	COG0751	glycine-tRNA ligase activity
KIV12_10015	COG0517	IMP dehydrogenase activity
KIV12_10020	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
KIV12_10025	COG1671	Belongs to the UPF0178 family
KIV12_10030	COG0358	DNA primase activity
KIV12_10035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KIV12_10040	COG2010	Cytochrome c
KIV12_10045	COG2384	SAM-dependent methyltransferase
KIV12_10050	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KIV12_10055	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KIV12_10065	COG0513	Belongs to the DEAD box helicase family
KIV12_10080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KIV12_10085	COG1121	(ABC) transporter
KIV12_10090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KIV12_10095	COG0735	belongs to the Fur family
KIV12_10100	COG1940	carbohydrate kinase activity
KIV12_10105	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
KIV12_10110	COG4709	membrane
KIV12_10115	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KIV12_10120	COG1388	LysM domain
KIV12_10125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KIV12_10130	COG5521	maltodextrose utilization protein MalA
KIV12_10135	COG2839	Protein conserved in bacteria
KIV12_10140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KIV12_10145	COG0477	Major facilitator Superfamily
KIV12_10150	COG0768	penicillin binding
KIV12_10155	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KIV12_10160	COG0573	inorganic phosphate transmembrane transporter activity
KIV12_10165	COG0581	inorganic phosphate transmembrane transporter activity
KIV12_10170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KIV12_10175	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KIV12_10180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KIV12_10190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KIV12_10195	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KIV12_10210	COG0457	Tetratricopeptide repeat
KIV12_10210	COG0705	Rhomboid family
KIV12_10215	COG4483	Protein conserved in bacteria
KIV12_10220	COG1940	carbohydrate kinase activity
KIV12_10225	COG1368	sulfuric ester hydrolase activity
KIV12_10230	COG2866	Carboxypeptidase
KIV12_10235	COG2814	Major facilitator Superfamily
KIV12_10240	COG0011	TIGRFAM Protein of
KIV12_10250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KIV12_10260	COG1393	Belongs to the ArsC family
KIV12_10270	COG1366	Belongs to the anti-sigma-factor antagonist family
KIV12_10275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KIV12_10280	COG1459	type II secretion system
KIV12_10285	COG4537	Required for transformation and DNA binding
KIV12_10290	COG4970	Tfp pilus assembly protein FimT
KIV12_10325	COG0681	Belongs to the peptidase S26 family
KIV12_10350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KIV12_10355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KIV12_10360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KIV12_10365	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KIV12_10370	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KIV12_10375	COG0095	Lipoate-protein ligase
KIV12_10380	COG1321	iron dependent repressor
KIV12_10385	COG1752	Esterase of the alpha-beta hydrolase superfamily
KIV12_10395	COG3872	metal-dependent enzyme
KIV12_10405	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KIV12_10410	COG0006	proline dipeptidase activity
KIV12_10415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KIV12_10425	COG3854	ATPases associated with a variety of cellular activities
KIV12_10465	COG0511	ligase activity, forming carbon-carbon bonds
KIV12_10470	COG0439	Biotin carboxylase
KIV12_10475	COG1302	Protein conserved in bacteria
KIV12_10480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KIV12_10485	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KIV12_10490	COG1570	exodeoxyribonuclease VII activity
KIV12_10495	COG1722	exodeoxyribonuclease VII activity
KIV12_10500	COG0142	geranyltranstransferase activity
KIV12_10505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KIV12_10510	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KIV12_10515	COG1438	arginine binding
KIV12_10520	COG0497	DNA recombination
KIV12_10525	COG0750	zinc metalloprotease
KIV12_10530	COG0745	RESPONSE REGULATOR receiver
KIV12_10535	COG0457	Tetratricopeptide repeat
KIV12_10540	COG0584	glycerophosphoryl diester phosphodiesterase
KIV12_10550	COG3829	transcription factor binding
KIV12_10550	COG3290	protein histidine kinase activity
KIV12_10555	COG0280	phosphate acetyltransferase
KIV12_10560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KIV12_10565	COG3426	butyrate kinase activity
KIV12_10570	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KIV12_10575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KIV12_10580	COG0022	dehydrogenase e1 component
KIV12_10585	COG0508	dehydrogenase complex catalyzes the overall conversion of
KIV12_10595	COG1597	lipid kinase activity
KIV12_10605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KIV12_10610	COG0765	amino acid transport
KIV12_10615	COG1126	abc transporter atp-binding protein
KIV12_10620	COG4129	membrane
KIV12_10625	COG1376	ErfK ybiS ycfS ynhG family protein
KIV12_10635	COG0346	lactoylglutathione lyase activity
KIV12_10640	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KIV12_10645	COG2195	Cleaves the N-terminal amino acid of tripeptides
KIV12_10650	COG0835	chemotaxis
KIV12_10655	COG0706	membrane insertase activity
KIV12_10665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KIV12_10670	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KIV12_10680	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_10685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KIV12_10690	COG1447	Phosphotransferase system cellobiose-specific component IIA
KIV12_10695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KIV12_10700	COG2723	6-phospho-beta-galactosidase activity
KIV12_10705	COG2188	Transcriptional regulator
KIV12_10710	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KIV12_10720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KIV12_10725	COG0596	Alpha beta hydrolase
KIV12_10730	COG1902	pentaerythritol trinitrate reductase activity
KIV12_10735	COG4187	Peptidase family M20/M25/M40
KIV12_10745	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KIV12_10750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KIV12_10755	COG0300	oxidoreductase activity
KIV12_10765	COG0446	pyridine nucleotide-disulphide oxidoreductase
KIV12_10770	COG1072	(Pantothenic acid kinase))
KIV12_10775	COG2211	Major facilitator Superfamily
KIV12_10785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KIV12_10795	COG0456	acetyltransferase
KIV12_10800	COG0456	acetyltransferase
KIV12_10800	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KIV12_10805	COG4305	rare lipoprotein A
KIV12_10810	COG4918	Iron-sulphur cluster biosynthesis
KIV12_10820	COG0457	Tetratricopeptide repeat
KIV12_10825	COG1073	alpha beta
KIV12_10835	COG0667	Aldo Keto reductase
KIV12_10840	COG0494	nUDIX hydrolase
KIV12_10845	COG1379	DNA repair
KIV12_10850	COG2153	protein acetylation
KIV12_10860	COG1404	Belongs to the peptidase S8 family
KIV12_10865	COG1300	Membrane
KIV12_10870	COG0735	belongs to the Fur family
KIV12_10880	COG4974	Belongs to the 'phage' integrase family
KIV12_10885	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KIV12_10890	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KIV12_10895	COG1686	Belongs to the peptidase S11 family
KIV12_10905	COG2172	sigma factor antagonist activity
KIV12_10910	COG1191	sigma factor activity
KIV12_10930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KIV12_10945	COG0697	spore germination
KIV12_10950	COG0019	diaminopimelate decarboxylase activity
KIV12_10955	COG4086	secreted protein
KIV12_10960	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KIV12_10985	COG0307	riboflavin synthase, alpha
KIV12_10990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KIV12_10990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KIV12_10995	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KIV12_11000	COG0456	acetyltransferase
KIV12_11005	COG1547	Domain of unknown function (DUF309)
KIV12_11015	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KIV12_11020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KIV12_11030	COG1686	Belongs to the peptidase S11 family
KIV12_11035	COG2715	membrane protein required for spore maturation
KIV12_11040	COG0700	Nucleoside recognition
KIV12_11045	COG1187	pseudouridine synthase activity
KIV12_11050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIV12_11055	COG1333	cytochrome c biogenesis protein
KIV12_11060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KIV12_11065	COG0745	RESPONSE REGULATOR receiver
KIV12_11070	COG5002	protein histidine kinase activity
KIV12_11075	COG1595	DNA-templated transcription, initiation
KIV12_11090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KIV12_11095	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KIV12_11100	COG1141	Ferredoxin
KIV12_11105	COG4955	Helix-turn-helix domain
KIV12_11110	COG0514	ATP-dependent DNA helicase (RecQ)
KIV12_11115	COG1266	CAAX protease self-immunity
KIV12_11120	COG1388	LysM domain
KIV12_11130	COG1408	metallophosphoesterase
KIV12_11135	COG4862	establishment of competence for transformation
KIV12_11140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KIV12_11145	COG0492	ferredoxin-NADP+ reductase activity
KIV12_11150	COG2339	peptidase activity
KIV12_11155	COG3773	Cell wall hydrolase
KIV12_11155	COG3409	Peptidoglycan-binding domain 1 protein
KIV12_11160	COG2959	enzyme of heme biosynthesis
KIV12_11165	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
KIV12_11175	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KIV12_11180	COG0539	negative regulation of cytoplasmic translation
KIV12_11185	COG1304	FMN binding
KIV12_11210	COG1160	GTP binding
KIV12_11215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KIV12_11230	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KIV12_11235	COG0776	regulation of translation
KIV12_11240	COG0302	gtp cyclohydrolase
KIV12_11250	COG0142	geranyltranstransferase activity
KIV12_11255	COG2226	methyltransferase
KIV12_11260	COG0142	geranyltranstransferase activity
KIV12_11265	COG0105	UTP biosynthetic process
KIV12_11270	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KIV12_11275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KIV12_11280	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KIV12_11285	COG4401	Chorismate mutase type I
KIV12_11295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KIV12_11300	COG0134	indole-3-glycerol-phosphate synthase activity
KIV12_11310	COG0133	tryptophan synthase activity
KIV12_11315	COG0159	tryptophan synthase activity
KIV12_11320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KIV12_11325	COG0287	Prephenate dehydrogenase
KIV12_11330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KIV12_11335	COG0457	Tetratricopeptide repeat
KIV12_11340	COG5582	Belongs to the UPF0302 family
KIV12_11350	COG0723	plastoquinol--plastocyanin reductase activity
KIV12_11355	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KIV12_11360	COG2010	Cytochrome c
KIV12_11360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KIV12_11365	COG4347	Protein of unknown function (DUF1405)
KIV12_11375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KIV12_11380	COG1694	Mazg nucleotide pyrophosphohydrolase
KIV12_11385	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KIV12_11390	COG1803	Methylglyoxal synthase
KIV12_11395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KIV12_11400	COG0438	transferase activity, transferring glycosyl groups
KIV12_11405	COG0617	tRNA 3'-terminal CCA addition
KIV12_11415	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KIV12_11420	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KIV12_11425	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KIV12_11430	COG1199	ATP-dependent helicase activity
KIV12_11430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KIV12_11440	COG5353	protein conserved in bacteria
KIV12_11445	COG0017	Asparaginyl-tRNA synthetase
KIV12_11450	COG3935	DnaD domain protein
KIV12_11455	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KIV12_11465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KIV12_11465	COG4499	WXG100 protein secretion system (Wss), protein YukC
KIV12_11470	COG3331	DNA recombination
KIV12_11500	COG0071	Belongs to the small heat shock protein (HSP20) family
KIV12_11505	COG2190	(PTS) system
KIV12_11510	COG1902	pentaerythritol trinitrate reductase activity
KIV12_11515	COG1111	helicase
KIV12_11515	COG1205	dead DEAH box helicase
KIV12_11520	COG3359	exonuclease
KIV12_11530	COG4474	Belongs to the UPF0398 family
KIV12_11535	COG3599	regulation of cell shape
KIV12_11545	COG0116	Belongs to the methyltransferase superfamily
KIV12_11555	COG1199	ATP-dependent helicase activity
KIV12_11560	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KIV12_11565	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KIV12_11570	COG2233	PERMEase
KIV12_11575	COG0726	polysaccharide deacetylase
KIV12_11580	COG3424	synthase
KIV12_11585	COG1755	Isoprenylcysteine carboxyl methyltransferase
KIV12_11595	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KIV12_11605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KIV12_11615	COG0328	RNA-DNA hybrid ribonuclease activity
KIV12_11620	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KIV12_11625	COG0328	RNA-DNA hybrid ribonuclease activity
KIV12_11640	COG1278	Cold shock
KIV12_11650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KIV12_11655	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KIV12_11660	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KIV12_11665	COG0386	Belongs to the glutathione peroxidase family
KIV12_11670	COG1418	mRNA catabolic process
KIV12_11675	COG1413	lyase activity
KIV12_11680	COG0129	dihydroxy-acid dehydratase activity
KIV12_11690	COG2136	Putative SAM-dependent methyltransferase
KIV12_11690	COG2521	methyltransferase
KIV12_11700	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KIV12_11705	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KIV12_11710	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KIV12_11715	COG0204	Acyl-transferase
KIV12_11720	COG1272	protein, Hemolysin III
KIV12_11725	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KIV12_11730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KIV12_11745	COG1999	signal sequence binding
KIV12_11750	COG2755	lipolytic protein G-D-S-L family
KIV12_11755	COG4698	Protein conserved in bacteria
KIV12_11775	COG1846	Transcriptional regulator
KIV12_11780	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KIV12_11785	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KIV12_11790	COG1086	Polysaccharide biosynthesis protein
KIV12_11800	COG4641	Protein conserved in bacteria
KIV12_11815	COG0463	Glycosyl transferase, family 2
KIV12_11820	COG3829	transcription factor binding
KIV12_11825	COG1509	lysine 2,3-aminomutase activity
KIV12_11835	COG4479	Belongs to the UPF0346 family
KIV12_11855	COG0671	phosphoesterase, PA-phosphatase related
KIV12_11865	COG0813	purine-nucleoside phosphorylase activity
KIV12_11870	COG1876	peptidase activity
KIV12_11880	COG2226	methyltransferase
KIV12_11885	COG0793	Belongs to the peptidase S41A family
KIV12_11885	COG3409	Peptidoglycan-binding domain 1 protein
KIV12_11890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KIV12_11900	COG0778	Nitroreductase
KIV12_11905	COG1733	regulation of RNA biosynthetic process
KIV12_11920	COG2962	Rard protein
KIV12_11930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KIV12_11935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KIV12_11940	COG0534	Mate efflux family protein
KIV12_11945	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KIV12_11950	COG0791	NLP P60 protein
KIV12_11950	COG1388	LysM domain
KIV12_11955	COG2032	superoxide dismutase activity
KIV12_11960	COG0714	Associated with various cellular activities
KIV12_11965	COG4548	von Willebrand factor, type A
KIV12_11970	COG0567	Dehydrogenase, E1 component
KIV12_11975	COG0508	dehydrogenase complex catalyzes the overall conversion of
KIV12_11980	COG0385	Bile acid
KIV12_11985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KIV12_11990	COG1657	PFAM Prenyltransferase squalene oxidase
KIV12_12000	COG1012	belongs to the aldehyde dehydrogenase family
KIV12_12025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KIV12_12035	COG0514	ATP-dependent DNA helicase (RecQ)
KIV12_12040	COG3584	3D domain protein
KIV12_12040	COG1388	LysM domain
KIV12_12050	COG2322	membrane
KIV12_12055	COG0372	Belongs to the citrate synthase family
KIV12_12060	COG2079	MmgE PrpD family protein
KIV12_12065	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KIV12_12070	COG0741	lytic transglycosylase activity
KIV12_12075	COG0531	amino acid
KIV12_12080	COG0640	Transcriptional regulator
KIV12_12090	COG2378	regulation of single-species biofilm formation
KIV12_12095	COG3708	Transcriptional regulator
KIV12_12100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KIV12_12105	COG1309	transcriptional regulator
KIV12_12125	COG1994	Peptidase M50
KIV12_12130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KIV12_12135	COG2211	Major facilitator Superfamily
KIV12_12145	COG1940	carbohydrate kinase activity
KIV12_12150	COG2115	Belongs to the xylose isomerase family
KIV12_12155	COG1070	Carbohydrate kinase
KIV12_12165	COG0243	molybdopterin cofactor binding
KIV12_12175	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KIV12_12180	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KIV12_12185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KIV12_12190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KIV12_12200	COG0454	-acetyltransferase
KIV12_12205	COG4978	Transcriptional regulator
KIV12_12205	COG0789	Transcriptional regulator
KIV12_12210	COG1132	(ABC) transporter
KIV12_12220	COG0583	DNA-binding transcription factor activity
KIV12_12225	COG0067	glutamate synthase
KIV12_12225	COG0070	glutamate synthase
KIV12_12225	COG0069	glutamate synthase activity
KIV12_12230	COG0493	'glutamate synthase
KIV12_12235	COG2223	nitrite transmembrane transporter activity
KIV12_12240	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KIV12_12245	COG0243	molybdopterin cofactor binding
KIV12_12250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KIV12_12255	COG2146	nitrite reductase [NAD(P)H] activity
KIV12_12260	COG2323	membrane
KIV12_12265	COG4677	pectinesterase activity
KIV12_12270	COG2027	D-alanyl-D-alanine carboxypeptidase
KIV12_12275	COG0534	Mate efflux family protein
KIV12_12295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KIV12_12305	COG1587	Uroporphyrinogen-III synthase
KIV12_12310	COG0586	Pfam SNARE associated Golgi protein
KIV12_12315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KIV12_12320	COG2246	polysaccharide biosynthetic process
KIV12_12325	COG0166	Belongs to the GPI family
KIV12_12345	COG0247	lactate metabolic process
KIV12_12350	COG0277	FAD linked oxidase domain protein
KIV12_12355	COG3835	regulator
KIV12_12365	COG1942	4-Oxalocrotonate Tautomerase
KIV12_12370	COG1349	DNA-binding transcription factor activity
KIV12_12380	COG1649	PFAM Uncharacterised BCR, COG1649
KIV12_12385	COG1960	acyl-CoA dehydrogenase activity
KIV12_12390	COG0318	PFAM AMP-dependent synthetase and ligase
KIV12_12395	COG0439	Biotin carboxylase
KIV12_12400	COG0511	ligase activity, forming carbon-carbon bonds
KIV12_12405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KIV12_12410	COG1024	Enoyl-CoA hydratase
KIV12_12415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KIV12_12420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KIV12_12425	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KIV12_12430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KIV12_12460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KIV12_12470	COG1105	Belongs to the carbohydrate kinase PfkB family
KIV12_12475	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KIV12_12475	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KIV12_12475	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KIV12_12480	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KIV12_12480	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KIV12_12480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KIV12_12490	COG2814	Major facilitator Superfamily
KIV12_12495	COG1846	Transcriptional regulator
KIV12_12500	COG5444	nuclease activity
KIV12_12515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KIV12_12530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KIV12_12535	COG1609	Transcriptional regulator
KIV12_12540	COG1653	transport
KIV12_12545	COG1175	transmembrane transport
KIV12_12550	COG0395	ABC-type sugar transport system, permease component
KIV12_12555	COG1486	melibiose metabolic process
KIV12_12560	COG1012	belongs to the aldehyde dehydrogenase family
KIV12_12565	COG3507	Belongs to the glycosyl hydrolase 43 family
KIV12_12575	COG0745	RESPONSE REGULATOR receiver
KIV12_12580	COG2205	protein histidine kinase activity
KIV12_12590	COG0789	Transcriptional regulator
KIV12_12595	COG0657	acetylesterase activity
KIV12_12635	COG0251	oxidation-reduction process
KIV12_12640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KIV12_12650	COG1733	regulation of RNA biosynthetic process
KIV12_12655	COG2249	NAD(P)H dehydrogenase (quinone) activity
KIV12_12660	COG1309	transcriptional regulator
KIV12_12670	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KIV12_12675	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KIV12_12685	COG0110	maltose O-acetyltransferase activity
KIV12_12690	COG0473	3-isopropylmalate dehydrogenase activity
KIV12_12695	COG0738	Major facilitator superfamily
KIV12_12705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KIV12_12710	COG0187	DNA topoisomerase II activity
KIV12_12715	COG1832	CoA-binding protein
KIV12_12720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KIV12_12725	COG4841	protein insertion into membrane
KIV12_12735	COG0824	Thioesterase
KIV12_12755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIV12_12760	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KIV12_12775	COG0071	Belongs to the small heat shock protein (HSP20) family
KIV12_12785	COG4846	Membrane protein involved in cytochrome C biogenesis
KIV12_12790	COG0785	Cytochrome C biogenesis protein
KIV12_12800	COG3763	UPF0154 protein
KIV12_12810	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KIV12_12815	COG4224	UPF0291 protein
KIV12_12820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KIV12_12825	COG1388	LysM domain
KIV12_12830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KIV12_12845	COG1366	Belongs to the anti-sigma-factor antagonist family
KIV12_12850	COG3209	COG3209 Rhs family protein
KIV12_12855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KIV12_12860	COG3591	Belongs to the peptidase S1B family
KIV12_12865	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KIV12_12865	COG2124	cytochrome p450
KIV12_12870	COG1309	transcriptional regulator
KIV12_12875	COG2323	membrane
KIV12_12895	COG1556	Lactate utilization protein
KIV12_12900	COG1139	Iron-sulfur cluster binding protein
KIV12_12905	COG0247	lactate metabolic process
KIV12_12915	COG0702	epimerase
KIV12_12920	COG1959	2 iron, 2 sulfur cluster binding
KIV12_12930	COG4876	unkown
KIV12_12935	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KIV12_12940	COG1793	dna ligase
KIV12_12940	COG3285	dna ligase
KIV12_12945	COG3619	membrane
KIV12_12955	COG0457	Tetratricopeptide repeat
KIV12_12960	COG5646	InterPro IPR014922
KIV12_13000	COG5444	nuclease activity
KIV12_13010	COG5444	nuclease activity
KIV12_13025	COG0457	Tetratricopeptide repeat
KIV12_13050	COG0860	N-Acetylmuramoyl-L-alanine amidase
KIV12_13055	COG4824	toxin secretion phage lysis holin
KIV12_13090	COG1705	Flagellar rod assembly protein muramidase FlgJ
KIV12_13165	COG1802	Transcriptional regulator
KIV12_13165	COG4626	Terminase
KIV12_13270	COG3645	SOS response
KIV12_13270	COG3646	Phage regulatory protein
KIV12_13290	COG4974	Belongs to the 'phage' integrase family
KIV12_13295	COG0174	glutamine synthetase
KIV12_13300	COG0789	Transcriptional regulator
KIV12_13305	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KIV12_13310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KIV12_13315	COG0464	growth
KIV12_13325	COG4112	unkown
KIV12_13330	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KIV12_13335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KIV12_13340	COG1780	Probably involved in ribonucleotide reductase function
KIV12_13355	COG1923	regulation of RNA biosynthetic process
KIV12_13360	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KIV12_13385	COG2076	Multidrug Resistance protein
KIV12_13390	COG1764	response to oxidative stress
KIV12_13395	COG4195	phage-related replication protein
KIV12_13400	COG1404	Belongs to the peptidase S8 family
KIV12_13405	COG0457	Tetratricopeptide repeat
KIV12_13410	COG4195	phage-related replication protein
KIV12_13415	COG1329	Transcriptional regulator
KIV12_13435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KIV12_13440	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KIV12_13450	COG4550	Control of competence regulator ComK, YlbF/YmcA
KIV12_13455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KIV12_13460	COG0156	8-amino-7-oxononanoate synthase activity
KIV12_13465	COG1063	alcohol dehydrogenase
KIV12_13470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KIV12_13475	COG2359	stage V sporulation protein S
KIV12_13480	COG1692	metallophosphoesterase
KIV12_13485	COG1418	mRNA catabolic process
KIV12_13490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
KIV12_13495	COG1058	Belongs to the CinA family
KIV12_13495	COG1546	Belongs to the CinA family
KIV12_13500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KIV12_13505	COG1426	Protein conserved in bacteria
KIV12_13520	COG0300	oxidoreductase activity
KIV12_13525	COG1033	growth of symbiont in host cell
KIV12_13525	COG2409	Drug exporters of the RND superfamily
KIV12_13535	COG0612	Peptidase, M16
KIV12_13540	COG0612	Peptidase, M16
KIV12_13545	COG2409	Drug exporters of the RND superfamily
KIV12_13545	COG1033	growth of symbiont in host cell
KIV12_13550	COG2814	Major facilitator Superfamily
KIV12_13555	COG2188	Transcriptional regulator
KIV12_13560	COG1674	ftsk spoiiie
KIV12_13560	COG4980	gas vesicle protein
KIV12_13570	COG0740	serine-type endopeptidase activity
KIV12_13575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KIV12_13585	COG0527	aspartate kinase activity
KIV12_13590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KIV12_13595	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KIV12_13600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KIV12_13605	COG1873	PFAM PRC-barrel domain
KIV12_13615	COG0612	Peptidase, M16
KIV12_13620	COG0726	polysaccharide deacetylase
KIV12_13625	COG1185	polyribonucleotide nucleotidyltransferase activity
KIV12_13630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KIV12_13635	COG0196	riboflavin kinase activity
KIV12_13640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KIV12_13645	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KIV12_13650	COG1550	Protein conserved in bacteria
KIV12_13655	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KIV12_13660	COG1358	cellular component organization or biogenesis
KIV12_13665	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KIV12_13670	COG0195	Participates in both transcription termination and antitermination
KIV12_13675	COG0779	Required for maturation of 30S ribosomal subunits
KIV12_13685	COG3693	PFAM glycoside hydrolase, family 10
KIV12_13700	COG2176	DNA-directed DNA polymerase activity
KIV12_13705	COG0442	prolyl-tRNA aminoacylation
KIV12_13710	COG0750	zinc metalloprotease
KIV12_13715	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KIV12_13720	COG4589	Belongs to the CDS family
KIV12_13725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KIV12_13730	COG0233	cytoplasmic translational termination
KIV12_13735	COG0528	UMP kinase activity
KIV12_13740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KIV12_13755	COG1191	sigma factor activity
KIV12_13765	COG1776	CheC inhibitor of MCP methylation
KIV12_13770	COG0835	chemotaxis
KIV12_13775	COG0643	Histidine kinase
KIV12_13775	COG2198	Histidine kinase
KIV12_13780	COG2201	protein-glutamate methylesterase activity
KIV12_13785	COG0455	bacterial-type flagellum organization
KIV12_13790	COG1419	protein localization to endoplasmic reticulum
KIV12_13795	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KIV12_13800	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KIV12_13805	COG1684	flagellar biosynthetic protein fliR
KIV12_13810	COG1987	bacterial-type flagellum assembly
KIV12_13815	COG1338	Plays a role in the flagellum-specific transport system
KIV12_13820	COG3190	flagellar
KIV12_13825	COG2201	protein-glutamate methylesterase activity
KIV12_13830	COG1776	CheC inhibitor of MCP methylation
KIV12_13830	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KIV12_13835	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KIV12_13840	COG1580	Controls the rotational direction of flagella during chemotaxis
KIV12_13845	COG1582	Flagellar protein (FlbD)
KIV12_13850	COG4786	Flagellar basal body rod
KIV12_13855	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KIV12_13860	COG3144	bacterial-type flagellum assembly
KIV12_13865	COG3334	PFAM MgtE intracellular
KIV12_13870	COG2882	bacterial-type flagellum organization
KIV12_13875	COG1157	protein secretion by the type III secretion system
KIV12_13880	COG1317	bacterial-type flagellum organization
KIV12_13885	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KIV12_13890	COG1766	The M ring may be actively involved in energy transduction
KIV12_13895	COG1677	Flagellar hook-basal body complex protein FliE
KIV12_13900	COG1558	bacterial-type flagellum-dependent cell motility
KIV12_13905	COG1815	bacterial-type flagellum-dependent cell motility
KIV12_13910	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KIV12_13915	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KIV12_13920	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KIV12_13925	COG4974	Belongs to the 'phage' integrase family
KIV12_13930	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KIV12_13935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KIV12_13940	COG0758	DNA mediated transformation
KIV12_13945	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KIV12_13950	COG0045	succinate-CoA ligase (ADP-forming) activity
KIV12_13955	COG2257	FlhB HrpN YscU SpaS Family
KIV12_13965	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KIV12_13970	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KIV12_13975	COG0335	large ribosomal subunit rRNA binding
KIV12_13980	COG0336	Belongs to the RNA methyltransferase TrmD family
KIV12_13985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KIV12_13995	COG1837	Belongs to the UPF0109 family
KIV12_14000	COG0228	four-way junction DNA binding
KIV12_14005	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KIV12_14010	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
KIV12_14015	COG0552	protein localization to endoplasmic reticulum
KIV12_14020	COG1196	nuclear chromosome segregation
KIV12_14030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KIV12_14035	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_14040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KIV12_14045	COG0416	fatty acid biosynthetic process
KIV12_14050	COG1349	DNA-binding transcription factor activity
KIV12_14055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KIV12_14060	COG1760	l-serine dehydratase
KIV12_14065	COG1760	l-serine dehydratase
KIV12_14070	COG1461	Dihydroxyacetone kinase
KIV12_14075	COG1302	Protein conserved in bacteria
KIV12_14080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KIV12_14090	COG1564	THIamine pyrophosphokinase
KIV12_14095	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KIV12_14100	COG1162	GTPase activity
KIV12_14105	COG0515	serine threonine protein kinase
KIV12_14105	COG2815	serine threonine protein kinase
KIV12_14110	COG0631	protein serine/threonine phosphatase activity
KIV12_14115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KIV12_14120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KIV12_14120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KIV12_14125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
KIV12_14130	COG0242	peptide deformylase activity
KIV12_14135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KIV12_14140	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KIV12_14145	COG1758	RNA polymerase activity
KIV12_14150	COG0194	GDP metabolic process
KIV12_14155	COG2052	Domain of unknown function (DUF370)
KIV12_14160	COG1561	YicC-like family, N-terminal region
KIV12_14165	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KIV12_14175	COG1648	precorrin-2 dehydrogenase activity
KIV12_14180	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
KIV12_14185	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KIV12_14190	COG0529	Catalyzes the synthesis of activated sulfate
KIV12_14195	COG2046	Belongs to the sulfate adenylyltransferase family
KIV12_14200	COG0306	phosphate transporter
KIV12_14205	COG0175	sulfate reduction
KIV12_14215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KIV12_14220	COG0284	orotidine-5'-phosphate decarboxylase activity
KIV12_14225	COG0167	dihydroorotate dehydrogenase activity
KIV12_14230	COG0543	2 iron, 2 sulfur cluster binding
KIV12_14235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KIV12_14240	COG0505	Belongs to the CarA family
KIV12_14245	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KIV12_14250	COG0540	Belongs to the ATCase OTCase family
KIV12_14255	COG2233	PERMEase
KIV12_14260	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
KIV12_14265	COG0564	pseudouridine synthase activity
KIV12_14270	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KIV12_14275	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KIV12_14280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KIV12_14285	COG3599	regulation of cell shape
KIV12_14290	COG2302	S4 RNA-binding domain
KIV12_14295	COG0762	integral membrane protein
KIV12_14300	COG1799	cell septum assembly
KIV12_14305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KIV12_14310	COG1496	oxidoreductase activity
KIV12_14315	COG1873	PFAM PRC-barrel domain
KIV12_14320	COG1119	ATPase activity
KIV12_14330	COG3732	PTS system glucitol sorbitol-specific
KIV12_14335	COG3730	PTS system glucitol sorbitol-specific
KIV12_14350	COG2390	Transcriptional regulator
KIV12_14355	COG1191	sigma factor activity
KIV12_14360	COG1191	sigma factor activity
KIV12_14370	COG1404	Belongs to the peptidase S8 family
KIV12_14370	COG4412	M6 family metalloprotease domain protein
KIV12_14375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KIV12_14380	COG0849	cell division
KIV12_14385	COG3856	small basic protein
KIV12_14390	COG3879	Bacterial protein of unknown function (DUF881)
KIV12_14395	COG3879	Bacterial protein of unknown function (DUF881)
KIV12_14400	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KIV12_14405	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KIV12_14410	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KIV12_14415	COG0772	Belongs to the SEDS family
KIV12_14420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KIV12_14425	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KIV12_14430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KIV12_14435	COG0768	penicillin binding
KIV12_14440	COG0768	penicillin binding
KIV12_14445	COG4839	cell division protein FtsL
KIV12_14450	COG0275	rRNA processing
KIV12_14455	COG2001	Belongs to the MraZ family
KIV12_14460	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
KIV12_14465	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KIV12_14470	COG0454	-acetyltransferase
KIV12_14480	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KIV12_14485	COG1399	metal-binding, possibly nucleic acid-binding protein
KIV12_14495	COG3480	Lon protease (S16) C-terminal proteolytic domain
KIV12_14500	COG1752	Esterase of the alpha-beta hydrolase superfamily
KIV12_14505	COG3314	Sporulation integral membrane protein YlbJ
KIV12_14510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KIV12_14515	COG0742	ribosomal rna small subunit methyltransferase
KIV12_14520	COG4471	UPF0298 protein
KIV12_14525	COG3679	Belongs to the UPF0342 family
KIV12_14545	COG2340	Cysteine-rich secretory protein family
KIV12_14550	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KIV12_14560	COG3336	cytochrome c oxidase
KIV12_14565	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KIV12_14570	COG1845	cytochrome c oxidase, subunit III
KIV12_14575	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KIV12_14580	COG2010	Cytochrome c
KIV12_14580	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KIV12_14585	COG0109	protoheme IX farnesyltransferase activity
KIV12_14590	COG1612	heme a metabolic process
KIV12_14595	COG0415	Belongs to the DNA photolyase family
KIV12_14600	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KIV12_14605	COG0772	Belongs to the SEDS family
KIV12_14610	COG4838	Belongs to the UPF0358 family
KIV12_14615	COG2066	Belongs to the glutaminase family
KIV12_14620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KIV12_14625	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KIV12_14635	COG4896	Protein conserved in bacteria
KIV12_14645	COG1217	gtp-binding protein TYPA
KIV12_14665	COG1595	DNA-templated transcription, initiation
KIV12_14680	COG0483	inositol monophosphate 1-phosphatase activity
KIV12_14690	COG4493	Belongs to the UPF0637 family
KIV12_14695	COG4476	Belongs to the UPF0223 family
KIV12_14700	COG1982	Orn Lys Arg decarboxylase major
KIV12_14710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIV12_14715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KIV12_14720	COG0508	dehydrogenase complex catalyzes the overall conversion of
KIV12_14725	COG0022	dehydrogenase e1 component
KIV12_14730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KIV12_14745	COG0242	peptide deformylase activity
KIV12_14750	COG0561	phosphatase activity
KIV12_14755	COG5503	Protein of unknown function (DUF1447)
KIV12_14760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KIV12_14765	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KIV12_14770	COG0569	domain protein
KIV12_14775	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
KIV12_14775	COG2105	PFAM AIG2 family protein
KIV12_14780	COG3852	Histidine kinase
KIV12_14785	COG2002	toxin-antitoxin pair type II binding
KIV12_14790	COG1077	Cell shape determining protein MreB Mrl
KIV12_14800	COG2309	aminopeptidase activity
KIV12_14810	COG0488	(ABC) transporter
KIV12_14825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KIV12_14825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KIV12_14825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KIV12_14830	COG1105	Belongs to the carbohydrate kinase PfkB family
KIV12_14835	COG1349	DNA-binding transcription factor activity
KIV12_14840	COG0577	efflux transmembrane transporter activity
KIV12_14845	COG1136	(ABC) transporter
KIV12_14850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KIV12_14865	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KIV12_14870	COG0314	molybdopterin synthase activity
KIV12_14875	COG1763	Mo-molybdopterin cofactor biosynthetic process
KIV12_14880	COG0303	'Molybdopterin
KIV12_14885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KIV12_14890	COG0746	molybdenum cofactor guanylyltransferase activity
KIV12_14905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIV12_14910	COG0450	alkyl hydroperoxide reductase
KIV12_14915	COG0668	transmembrane transport
KIV12_14925	COG1473	amidohydrolase
KIV12_14930	COG2171	N-acyltransferase activity
KIV12_14935	COG0716	FMN binding
KIV12_14945	COG0716	FMN binding
KIV12_14955	COG0583	DNA-binding transcription factor activity
KIV12_14960	COG0517	IMP dehydrogenase activity
KIV12_14970	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
KIV12_14975	COG4703	Protein of unknown function (DUF1797)
KIV12_14980	COG3546	catalase activity
KIV12_14985	COG2200	EAL domain
KIV12_14990	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_14995	COG1408	metallophosphoesterase
KIV12_15000	COG1376	ErfK ybiS ycfS ynhG family protein
KIV12_15005	COG2814	Major facilitator Superfamily
KIV12_15025	COG0784	Response regulator, receiver
KIV12_15025	COG0835	chemotaxis
KIV12_15035	COG1714	RDD family
KIV12_15045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KIV12_15050	COG0436	Aminotransferase
KIV12_15055	COG4191	Histidine kinase
KIV12_15060	COG0768	penicillin binding
KIV12_15065	COG2340	Cysteine-rich secretory protein family
KIV12_15070	COG2084	Dehydrogenase
KIV12_15080	COG0840	transmembrane signaling receptor activity
KIV12_15085	COG1533	DNA photolyase activity
KIV12_15095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KIV12_15100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KIV12_15105	COG1263	PTS System
KIV12_15105	COG2190	(PTS) system
KIV12_15105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KIV12_15110	COG3711	transcriptional antiterminator
KIV12_15115	COG1609	Transcriptional regulator
KIV12_15120	COG0006	proline dipeptidase activity
KIV12_15125	COG2217	Heavy metal translocating P-type atpase
KIV12_15130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIV12_15135	COG2244	polysaccharide biosynthetic process
KIV12_15140	COG3773	Cell wall hydrolase
KIV12_15150	COG4873	Protein conserved in bacteria
KIV12_15160	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KIV12_15165	COG0602	queuosine metabolic process
KIV12_15170	COG0720	synthase
KIV12_15175	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KIV12_15180	COG3949	Membrane
KIV12_15185	COG0542	response to heat
KIV12_15195	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KIV12_15200	COG1360	Flagellar Motor Protein
KIV12_15205	COG1846	Transcriptional regulator
KIV12_15210	COG3852	Histidine kinase
KIV12_15220	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KIV12_15225	COG0235	Class ii aldolase
KIV12_15230	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
KIV12_15235	COG1850	ribulose-bisphosphate carboxylase activity
KIV12_15240	COG0436	Aminotransferase
KIV12_15245	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
KIV12_15250	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KIV12_15255	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KIV12_15260	COG5002	protein histidine kinase activity
KIV12_15265	COG3594	Acyltransferase
KIV12_15280	COG2323	membrane
KIV12_15285	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KIV12_15290	COG0501	Belongs to the peptidase M48B family
KIV12_15310	COG1191	sigma factor activity
KIV12_15315	COG0861	Integral membrane protein TerC family
KIV12_15320	COG0586	Pfam SNARE associated Golgi protein
KIV12_15325	COG5001	Diguanylate cyclase
KIV12_15325	COG3300	MHYT domain
KIV12_15330	COG1846	Transcriptional regulator
KIV12_15345	COG0789	Transcriptional regulator
KIV12_15355	COG0583	DNA-binding transcription factor activity
KIV12_15365	COG2239	Acts as a magnesium transporter
KIV12_15375	COG3212	peptidase
KIV12_15380	COG3212	peptidase
KIV12_15385	COG5002	protein histidine kinase activity
KIV12_15385	COG3850	Histidine kinase
KIV12_15390	COG0745	RESPONSE REGULATOR receiver
KIV12_15405	COG1404	Belongs to the peptidase S8 family
KIV12_15410	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KIV12_15415	COG0590	tRNA wobble adenosine to inosine editing
KIV12_15420	COG1764	response to oxidative stress
KIV12_15425	COG1846	Transcriptional regulator
KIV12_15430	COG1764	response to oxidative stress
KIV12_15440	COG0457	Tetratricopeptide repeat
KIV12_15445	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KIV12_15450	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KIV12_15455	COG0788	formyltetrahydrofolate deformylase activity
KIV12_15465	COG2076	Multidrug Resistance protein
KIV12_15470	COG2076	Multidrug Resistance protein
KIV12_15480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KIV12_15495	COG1695	Transcriptional regulator
KIV12_15500	COG1607	acyl-coa hydrolase
KIV12_15505	COG1834	amidinotransferase
KIV12_15510	COG4608	Belongs to the ABC transporter superfamily
KIV12_15515	COG0791	NLP P60 protein
KIV12_15520	COG4948	Mandelate Racemase Muconate Lactonizing
KIV12_15525	COG1619	proteins homologs of microcin C7 resistance protein MccF
KIV12_15530	COG4166	transmembrane transport
KIV12_15535	COG0444	Belongs to the ABC transporter superfamily
KIV12_15540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIV12_15545	COG0601	transmembrane transport
KIV12_15550	COG2362	D-Aminopeptidase
KIV12_15555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KIV12_15560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KIV12_15565	COG0346	lactoylglutathione lyase activity
KIV12_15570	COG0531	amino acid
KIV12_15580	COG2390	Transcriptional regulator
KIV12_15585	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_15590	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_15595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KIV12_15600	COG0508	dehydrogenase complex catalyzes the overall conversion of
KIV12_15605	COG0508	dehydrogenase complex catalyzes the overall conversion of
KIV12_15605	COG0022	dehydrogenase e1 component
KIV12_15610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KIV12_15615	COG1063	alcohol dehydrogenase
KIV12_15630	COG3775	system Galactitol-specific IIC component
KIV12_15640	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
KIV12_15645	COG4208	sulfate ABC transporter
KIV12_15655	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
KIV12_15660	COG0405	Gamma-glutamyltransferase
KIV12_15670	COG1392	Phosphate transport regulator
KIV12_15675	COG0306	phosphate transporter
KIV12_15690	COG3409	Peptidoglycan-binding domain 1 protein
KIV12_15690	COG5632	N-Acetylmuramoyl-L-alanine amidase
KIV12_15695	COG2856	Zn peptidase
KIV12_15700	COG4195	phage-related replication protein
KIV12_15720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KIV12_15725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KIV12_15735	COG1309	transcriptional regulator
KIV12_15745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KIV12_15775	COG2807	transmembrane transport
KIV12_15780	COG0583	DNA-binding transcription factor activity
KIV12_15800	COG0583	DNA-binding transcription factor activity
KIV12_15815	COG0457	Tetratricopeptide repeat
KIV12_15835	COG0825	malonyl-CoA metabolic process
KIV12_15860	COG0626	cystathionine gamma-synthase activity
KIV12_15865	COG0626	cystathionine gamma-synthase activity
KIV12_15870	COG2382	esterase
KIV12_15875	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KIV12_15880	COG2153	protein acetylation
KIV12_15890	COG0210	DNA helicase
KIV12_15945	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KIV12_15950	COG0351	phosphomethylpyrimidine kinase
KIV12_15955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KIV12_15960	COG2022	thiamine diphosphate biosynthetic process
KIV12_15965	COG2104	thiamine diphosphate biosynthetic process
KIV12_15975	COG0352	thiamine-phosphate diphosphorylase activity
KIV12_15980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KIV12_15985	COG0475	glutathione-regulated potassium exporter activity
KIV12_15985	COG0569	domain protein
KIV12_15990	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KIV12_15995	COG0564	pseudouridine synthase activity
KIV12_16000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KIV12_16005	COG2357	RelA SpoT domain protein
KIV12_16015	COG4116	CYTH
KIV12_16020	COG0741	lytic transglycosylase activity
KIV12_16025	COG2346	COG2346, Truncated hemoglobins
KIV12_16030	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KIV12_16040	COG1164	Oligoendopeptidase f
KIV12_16050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KIV12_16055	COG4862	establishment of competence for transformation
KIV12_16060	COG0861	Integral membrane protein TerC family
KIV12_16065	COG1393	Belongs to the ArsC family
KIV12_16070	COG0456	acetyltransferase
KIV12_16080	COG4608	Belongs to the ABC transporter superfamily
KIV12_16085	COG0444	Belongs to the ABC transporter superfamily
KIV12_16090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIV12_16095	COG0601	transmembrane transport
KIV12_16100	COG4166	transmembrane transport
KIV12_16110	COG0180	Tryptophanyl-tRNA synthetase
KIV12_16140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KIV12_16145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIV12_16150	COG0601	transmembrane transport
KIV12_16160	COG4608	Belongs to the ABC transporter superfamily
KIV12_16165	COG0444	Belongs to the ABC transporter superfamily
KIV12_16170	COG5504	Zn-dependent protease
KIV12_16175	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KIV12_16180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KIV12_16195	COG1744	ABC transporter substrate-binding protein PnrA-like
KIV12_16205	COG2267	carboxylic ester hydrolase activity
KIV12_16215	COG2814	Major facilitator Superfamily
KIV12_16225	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KIV12_16230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KIV12_16235	COG0505	Belongs to the CarA family
KIV12_16240	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KIV12_16245	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KIV12_16250	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KIV12_16255	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KIV12_16260	COG2271	Major facilitator Superfamily
KIV12_16265	COG0277	FAD linked oxidase domain protein
KIV12_16270	COG2151	metal-sulfur cluster biosynthetic enzyme
KIV12_16275	COG1073	alpha beta
KIV12_16280	COG0561	phosphatase activity
KIV12_16300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KIV12_16305	COG1307	EDD domain protein, DegV family
KIV12_16310	COG0840	transmembrane signaling receptor activity
KIV12_16315	COG1744	ABC transporter substrate-binding protein PnrA-like
KIV12_16320	COG2996	Protein conserved in bacteria
KIV12_16325	COG1666	GTP binding
KIV12_16330	COG0646	methionine synthase
KIV12_16330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KIV12_16335	COG0646	methionine synthase
KIV12_16335	COG1410	methionine synthase
KIV12_16370	COG0076	glutamate decarboxylase activity
KIV12_16395	COG1917	Cupin 2, conserved barrel domain protein
KIV12_16395	COG2207	Transcriptional regulator
KIV12_16400	COG0534	Mate efflux family protein
KIV12_16405	COG1562	ergosterol biosynthetic process
KIV12_16420	COG0367	asparagine synthase
KIV12_16435	COG0179	Fumarylacetoacetate (FAA) hydrolase
KIV12_16440	COG5337	Spore coat protein CotH
KIV12_16480	COG1403	HNH endonuclease
KIV12_16485	COG0419	ATPase involved in DNA repair
KIV12_16490	COG0420	3'-5' exonuclease activity
KIV12_16495	COG1074	ATP-dependent DNA helicase activity
KIV12_16500	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
KIV12_16505	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KIV12_16510	COG2259	Doxx family
KIV12_16525	COG3180	Ammonia monooxygenase
KIV12_16530	COG0681	Belongs to the peptidase S26 family
KIV12_16535	COG0398	Pfam SNARE associated Golgi protein
KIV12_16550	COG1316	TRANSCRIPTIONal
KIV12_16555	COG4607	ABC-type enterochelin transport system periplasmic component
KIV12_16560	COG4604	ABC transporter, ATP-binding protein
KIV12_16565	COG4605	iron ion homeostasis
KIV12_16570	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KIV12_16575	COG2732	(Barnase) inhibitor
KIV12_16580	COG2814	Major facilitator Superfamily
KIV12_16585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KIV12_16600	COG4903	ComK protein
KIV12_16610	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_16615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KIV12_16615	COG0723	plastoquinol--plastocyanin reductase activity
KIV12_16620	COG0840	transmembrane signaling receptor activity
KIV12_16625	COG0406	alpha-ribazole phosphatase activity
KIV12_16630	COG1404	Belongs to the peptidase S8 family
KIV12_16635	COG0501	Belongs to the peptidase M48B family
KIV12_16645	COG0318	PFAM AMP-dependent synthetase and ligase
KIV12_16650	COG0095	Lipoate-protein ligase
KIV12_16655	COG1234	tRNA 3'-trailer cleavage
KIV12_16665	COG1301	dicarboxylic acid transport
KIV12_16670	COG1363	Peptidase, m42
KIV12_16675	COG1511	domain protein
KIV12_16680	COG1309	transcriptional regulator
KIV12_16685	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KIV12_16690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KIV12_16695	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KIV12_16700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KIV12_16705	COG2329	Antibiotic biosynthesis monooxygenase
KIV12_16715	COG1473	amidohydrolase
KIV12_16725	COG4473	ABC transporter
KIV12_16730	COG1131	(ABC) transporter
KIV12_16735	COG0537	adenosine 5'-monophosphoramidase activity
KIV12_16740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KIV12_16755	COG4980	gas vesicle protein
KIV12_16760	COG1846	Transcriptional regulator
KIV12_16785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KIV12_16795	COG3481	metal-dependent phosphohydrolase, HD sub domain
KIV12_16800	COG4717	serine-type aminopeptidase activity
KIV12_16805	COG0420	3'-5' exonuclease activity
KIV12_16815	COG1024	Enoyl-CoA hydratase
KIV12_16825	COG0490	domain, Protein
KIV12_16830	COG0475	glutathione-regulated potassium exporter activity
KIV12_16840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KIV12_16845	COG0561	phosphatase activity
KIV12_16850	COG3679	Belongs to the UPF0342 family
KIV12_16855	COG4399	Belongs to the UPF0754 family
KIV12_16860	COG0189	ligase activity
KIV12_16865	COG0189	ligase activity
KIV12_16875	COG2508	Transcriptional regulator
KIV12_16880	COG3842	ATPase activity
KIV12_16890	COG0702	epimerase
KIV12_16895	COG1132	(ABC) transporter
KIV12_16900	COG1132	(ABC) transporter
KIV12_16905	COG0589	response to stress
KIV12_16910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KIV12_16915	COG0726	polysaccharide deacetylase
KIV12_16920	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KIV12_16925	COG0668	transmembrane transport
KIV12_16935	COG0584	glycerophosphoryl diester phosphodiesterase
KIV12_16940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KIV12_16955	COG1253	flavin adenine dinucleotide binding
KIV12_16960	COG0789	Transcriptional regulator
KIV12_16965	COG1253	flavin adenine dinucleotide binding
KIV12_16970	COG0204	Acyl-transferase
KIV12_16975	COG1595	DNA-templated transcription, initiation
KIV12_16990	COG0791	NLP P60 protein
KIV12_16990	COG1388	LysM domain
KIV12_17000	COG2719	SpoVR family
KIV12_17005	COG1017	nitric oxide dioxygenase activity
KIV12_17005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KIV12_17010	COG1959	2 iron, 2 sulfur cluster binding
KIV12_17015	COG0753	catalase activity
KIV12_17030	COG2197	response regulator
KIV12_17035	COG2203	Gaf domain
KIV12_17035	COG4585	Histidine kinase
KIV12_17040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KIV12_17045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KIV12_17050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KIV12_17055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KIV12_17060	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KIV12_17065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KIV12_17070	COG3835	regulator
KIV12_17090	COG3153	acetyltransferase
KIV12_17090	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KIV12_17095	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KIV12_17105	COG0564	pseudouridine synthase activity
KIV12_17110	COG3764	Sortase (surface protein transpeptidase)
KIV12_17115	COG1525	nuclease
KIV12_17115	COG4085	toxin activity
KIV12_17115	COG0737	Belongs to the 5'-nucleotidase family
KIV12_17120	COG5002	protein histidine kinase activity
KIV12_17125	COG5577	PFAM Coat F domain
KIV12_17150	COG3706	GGDEF domain
KIV12_17155	COG1278	Cold shock
KIV12_17165	COG0655	NAD(P)H dehydrogenase (quinone) activity
KIV12_17170	COG2814	Major facilitator Superfamily
KIV12_17175	COG1566	PFAM secretion protein HlyD family protein
KIV12_17180	COG2718	Belongs to the UPF0229 family
KIV12_17185	COG2766	serine protein kinase
KIV12_17190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KIV12_17200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KIV12_17205	COG3382	B3 4 domain protein
KIV12_17235	COG1131	(ABC) transporter
KIV12_17250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KIV12_17255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KIV12_17260	COG1116	anion transmembrane transporter activity
KIV12_17270	COG2873	o-acetylhomoserine
KIV12_17275	COG0681	Belongs to the peptidase S26 family
KIV12_17280	COG1368	sulfuric ester hydrolase activity
KIV12_17440	COG0735	belongs to the Fur family
KIV12_17445	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KIV12_17450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KIV12_17455	COG4129	membrane
KIV12_17460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KIV12_17465	COG0601	transmembrane transport
KIV12_17470	COG0747	negative chemotaxis
KIV12_17475	COG4608	Belongs to the ABC transporter superfamily
KIV12_17480	COG0444	Belongs to the ABC transporter superfamily
KIV12_17485	COG1132	(ABC) transporter
KIV12_17490	COG3557	Belongs to the UPF0374 family
KIV12_17505	COG1028	Short-chain dehydrogenase reductase Sdr
KIV12_17515	COG1194	a g-specific adenine glycosylase
KIV12_17520	COG1988	membrane-bound metal-dependent
KIV12_17530	COG1191	sigma factor activity
KIV12_17540	COG2140	Oxalate decarboxylase
KIV12_17555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KIV12_17560	COG4485	Bacterial membrane protein, YfhO
KIV12_17565	COG0463	Glycosyl transferase, family 2
KIV12_17590	COG2137	regulation of response to DNA damage stimulus
KIV12_17595	COG1090	epimerase
KIV12_17610	COG0778	Nitroreductase
KIV12_17630	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KIV12_17630	COG0392	lysyltransferase activity
KIV12_17635	COG1846	Transcriptional regulator
KIV12_17645	COG2318	DinB family
KIV12_17665	COG1595	DNA-templated transcription, initiation
KIV12_17670	COG1742	UPF0060 membrane protein
KIV12_17675	COG1132	(ABC) transporter
KIV12_17680	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KIV12_17685	COG2169	Transcriptional regulator
KIV12_17690	COG0492	ferredoxin-NADP+ reductase activity
KIV12_17695	COG2755	lipolytic protein G-D-S-L family
KIV12_17700	COG4637	Psort location Cytoplasmic, score
KIV12_17710	COG1309	transcriptional regulator
KIV12_17715	COG2076	Multidrug Resistance protein
KIV12_17720	COG2076	Multidrug Resistance protein
KIV12_17765	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KIV12_17780	COG2814	Major facilitator Superfamily
KIV12_17785	COG0789	Transcriptional regulator
KIV12_17815	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KIV12_17820	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KIV12_17830	COG0598	Magnesium transport protein CorA
KIV12_17840	COG0726	polysaccharide deacetylase
KIV12_17850	COG0535	radical SAM domain protein
KIV12_17855	COG0668	transmembrane transport
KIV12_17860	COG0217	transcriptional regulatory protein
KIV12_17870	COG0387	Pfam Sodium calcium exchanger
KIV12_17880	COG0477	Major facilitator Superfamily
KIV12_17885	COG1295	ribonuclease BN
KIV12_17890	COG4980	gas vesicle protein
KIV12_17895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KIV12_17900	COG1115	amino acid carrier protein
KIV12_17905	COG4840	Belongs to the UPF0435 family
KIV12_17910	COG0693	protein deglycase activity
KIV12_17915	COG0737	Belongs to the 5'-nucleotidase family
KIV12_17925	COG2188	Transcriptional regulator
KIV12_17930	COG0366	Alpha amylase catalytic
KIV12_17935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KIV12_17935	COG1263	PTS System
KIV12_17945	COG0840	transmembrane signaling receptor activity
KIV12_17950	COG0076	glutamate decarboxylase activity
KIV12_17955	COG1368	sulfuric ester hydrolase activity
KIV12_17970	COG3739	integral membrane protein
KIV12_17975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KIV12_17975	COG1263	PTS System
KIV12_17980	COG0024	Methionine aminopeptidase
KIV12_17995	COG2258	MOSC domain
KIV12_18000	COG1254	Belongs to the acylphosphatase family
KIV12_18010	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KIV12_18015	COG1695	Transcriptional regulator
KIV12_18020	COG3479	Phenolic acid decarboxylase
KIV12_18030	COG2851	Citrate transporter
KIV12_18035	COG3181	Tripartite tricarboxylate transporter family receptor
KIV12_18040	COG4565	transcriptional regulatory protein
KIV12_18045	COG3290	protein histidine kinase activity
KIV12_18055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KIV12_18055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KIV12_18065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
KIV12_18070	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KIV12_18070	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KIV12_18090	COG2130	NADP-dependent
KIV12_18095	COG0513	Belongs to the DEAD box helicase family
KIV12_18100	COG0488	(ABC) transporter
KIV12_18105	COG2814	Major facilitator Superfamily
KIV12_18110	COG0789	Transcriptional regulator
KIV12_18115	COG1469	GTP cyclohydrolase I activity
KIV12_18120	COG0488	(ABC) transporter
KIV12_18125	COG0463	Glycosyl transferase, family 2
KIV12_18125	COG0457	Tetratricopeptide repeat
KIV12_18130	COG0531	amino acid
KIV12_18145	COG0071	Belongs to the small heat shock protein (HSP20) family
KIV12_18160	COG0471	metal ion transport
KIV12_18170	COG2223	nitrite transmembrane transporter activity
KIV12_18175	COG1442	glycosyl transferase family 8
KIV12_18180	COG1216	Glycosyl transferase, family 2
KIV12_18185	COG1442	glycosyl transferase family 8
KIV12_18190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KIV12_18195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KIV12_18235	COG1486	melibiose metabolic process
KIV12_18250	COG0492	ferredoxin-NADP+ reductase activity
KIV12_18255	COG1959	2 iron, 2 sulfur cluster binding
KIV12_18270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KIV12_18295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KIV12_18300	COG1597	lipid kinase activity
KIV12_18305	COG1957	nucleoside hydrolase
KIV12_18310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KIV12_18315	COG1309	transcriptional regulator
KIV12_18320	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KIV12_18325	COG0154	amidase activity
KIV12_18330	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KIV12_18335	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KIV12_18340	COG1285	pathogenesis
KIV12_18345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KIV12_18350	COG4851	CamS sex pheromone cAM373 precursor
KIV12_18355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KIV12_18360	COG0210	DNA helicase
KIV12_18365	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
KIV12_18380	COG0069	glutamate synthase activity
KIV12_18390	COG4496	protein, YerC YecD
KIV12_18395	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KIV12_18405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KIV12_18410	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KIV12_18415	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KIV12_18420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KIV12_18440	COG0151	Belongs to the GarS family
KIV12_18445	COG0138	bifunctional purine biosynthesis protein purh
KIV12_18450	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KIV12_18455	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KIV12_18460	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KIV12_18465	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KIV12_18470	COG0047	phosphoribosylformylglycinamidine synthase activity
KIV12_18475	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KIV12_18480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KIV12_18485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KIV12_18490	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KIV12_18495	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KIV12_18505	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
KIV12_18510	COG3064	Membrane
KIV12_18515	COG5583	Uncharacterized small protein (DUF2292)
KIV12_18525	COG2252	PERMEase
KIV12_18530	COG0583	DNA-binding transcription factor activity
KIV12_18535	COG2814	Major facilitator Superfamily
KIV12_18545	COG1595	DNA-templated transcription, initiation
KIV12_18580	COG0519	Catalyzes the synthesis of GMP from XMP
KIV12_18580	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KIV12_18585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KIV12_18590	COG2207	Transcriptional regulator
KIV12_18590	COG1609	Transcriptional regulator
KIV12_18595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KIV12_18600	COG0519	Catalyzes the synthesis of GMP from XMP
KIV12_18600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KIV12_18605	COG1305	Transglutaminase-like
KIV12_18610	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KIV12_18615	COG0714	Associated with various cellular activities
KIV12_18620	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KIV12_18625	COG1113	amino acid transport
KIV12_18630	COG2132	Multicopper oxidase
KIV12_18640	COG0823	Involved in the tonB-independent uptake of proteins
KIV12_18645	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KIV12_18685	COG0459	protein refolding
KIV12_18690	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KIV12_18695	COG1266	CAAX protease self-immunity
KIV12_18710	COG0805	protein transport
KIV12_18715	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KIV12_18720	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KIV12_18725	COG0315	cyclic pyranopterin monophosphate synthase activity
KIV12_18730	COG0488	(ABC) transporter
KIV12_18735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KIV12_18740	COG0456	acetyltransferase
KIV12_18745	COG1214	PFAM Peptidase M22, glycoprotease
KIV12_18750	COG0802	atpase or kinase
KIV12_18755	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KIV12_18795	COG1301	dicarboxylic acid transport
KIV12_18805	COG0697	spore germination
KIV12_18810	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
KIV12_18820	COG4122	O-methyltransferase activity
KIV12_18830	COG0456	acetyltransferase
KIV12_18840	COG1396	sequence-specific DNA binding
KIV12_18855	COG0778	Nitroreductase
KIV12_18860	COG1846	Transcriptional regulator
KIV12_18865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KIV12_18870	COG1309	transcriptional regulator
KIV12_18915	COG2197	response regulator
KIV12_18920	COG4585	Histidine kinase
KIV12_18925	COG2409	Drug exporters of the RND superfamily
KIV12_18930	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
KIV12_18935	COG2814	Major facilitator Superfamily
KIV12_18950	COG2267	carboxylic ester hydrolase activity
KIV12_18955	COG0252	asparaginase activity
KIV12_18965	COG4221	oxidoreductase activity
KIV12_18975	COG0657	acetylesterase activity
KIV12_18980	COG0477	Major facilitator Superfamily
KIV12_18995	COG0789	Transcriptional regulator
KIV12_19000	COG1064	alcohol dehydrogenase
KIV12_19005	COG1329	Transcriptional regulator
KIV12_19010	COG1278	Cold shock
KIV12_19015	COG0456	acetyltransferase
KIV12_19015	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KIV12_19035	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
KIV12_19075	COG3284	Transcriptional regulator
KIV12_19080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KIV12_19085	COG0508	dehydrogenase complex catalyzes the overall conversion of
KIV12_19090	COG0022	dehydrogenase e1 component
KIV12_19095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KIV12_19100	COG3091	SprT-like family
KIV12_19110	COG2183	response to ionizing radiation
KIV12_19115	COG2208	phosphoserine phosphatase activity
KIV12_19120	COG1191	sigma factor activity
KIV12_19125	COG2172	sigma factor antagonist activity
KIV12_19130	COG1366	Belongs to the anti-sigma-factor antagonist family
KIV12_19135	COG2208	phosphoserine phosphatase activity
KIV12_19140	COG2172	sigma factor antagonist activity
KIV12_19145	COG1366	Belongs to the anti-sigma-factor antagonist family
KIV12_19150	COG1366	Belongs to the anti-sigma-factor antagonist family
KIV12_19155	COG2337	Toxic component of a toxin-antitoxin (TA) module
KIV12_19160	COG0864	Transcriptional regulator
KIV12_19165	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KIV12_19170	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KIV12_19175	COG0736	holo-[acyl-carrier-protein] synthase activity
KIV12_19180	COG0705	Rhomboid family
KIV12_19185	COG3428	Bacterial PH domain
KIV12_19190	COG3402	PFAM membrane-flanked domain
KIV12_19195	COG0513	Belongs to the DEAD box helicase family
KIV12_19210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KIV12_19215	COG1181	Belongs to the D-alanine--D-alanine ligase family
KIV12_19220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KIV12_19235	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component