locus-tag class description CSE15_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CSE15_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CSE15_00015 ENOG410848D S4 domain protein YaaA CSE15_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CSE15_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CSE15_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CSE15_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CSE15_00080 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CSE15_00085 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) CSE15_00090 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) CSE15_00095 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CSE15_00100 ENOG4105FKZ Methyl-accepting chemotaxis CSE15_00110 ENOG4105ZMH deoxynucleoside kinase CSE15_00120 ENOG4105VRS hydrolase family 18 CSE15_00125 ENOG4105GTG Isochorismatase CSE15_00130 ENOG4108Z6B deaminase CSE15_00140 ENOG4105C6E dna polymerase iii CSE15_00145 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CSE15_00150 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CSE15_00160 ENOG41067KS pro-sigma K processing CSE15_00200 ENOG4105CDW Resistance protein CSE15_00205 ENOG4105CXN decarboxylase CSE15_00210 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CSE15_00215 ENOG4105X0R protein from nitrogen regulatory protein P-II CSE15_00220 ENOG4105XVJ Protein of unknown function (DUF327) CSE15_00225 ENOG4105FA2 dna polymerase iii CSE15_00230 ENOG4105MA4 psp1 domain protein CSE15_00235 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) CSE15_00240 ENOG41060K3 Methyltransferase CSE15_00245 ENOG4105VC4 domain protein CSE15_00250 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CSE15_00255 ENOG4105KRN Transcriptional regulator, abrb family CSE15_00265 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CSE15_00270 ENOG4105F8V Hydrolase, tatD family CSE15_00275 ENOG41069ER domain protein CSE15_00285 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CSE15_00290 ENOG4105XFA sporulation peptidase YabG CSE15_00295 ENOG4105W42 Veg protein CSE15_00300 ENOG4105XEW small acid-soluble spore protein CSE15_00305 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CSE15_00310 ENOG4105DFT pur operon repressor CSE15_00315 ENOG4105KME endoribonuclease L-psp CSE15_00325 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CSE15_00330 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CSE15_00335 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CSE15_00340 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CSE15_00350 ENOG4108JA2 transcriptioN-repair coupling factor CSE15_00355 ENOG4108M14 stage v sporulation protein t CSE15_00365 ENOG4108IY2 MazG family CSE15_00370 ENOG41082I2 s4 domain protein CSE15_00375 ENOG4105VYY sporulation protein yabp CSE15_00390 ENOG41060GV RNA binding s1 domain protein CSE15_00420 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CSE15_00425 ENOG4108UGV hypoxanthine phosphoribosyltransferase CSE15_00430 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CSE15_00435 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) CSE15_00440 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) CSE15_00445 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase CSE15_00450 ENOG4105C6T cysteine synthase CSE15_00455 ENOG4105CRQ synthase (Component I) CSE15_00460 ENOG4105DDQ anthranilate synthase CSE15_00465 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CSE15_00470 ENOG4105EEI dihydropteroate synthase CSE15_00475 ENOG4105KRF dihydroneopterin aldolase CSE15_00480 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CSE15_00490 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CSE15_00495 ENOG4105CRK lysyL-tRNA synthetase CSE15_00580 ENOG4108Z0C Uvrb UvrC protein CSE15_00585 ENOG41066A3 ATP guanido phosphotransferase CSE15_00595 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CSE15_00600 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) CSE15_00605 ENOG4105CTP PilT protein domain protein CSE15_00610 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CSE15_00615 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CSE15_00620 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CSE15_00625 ENOG4105D7W serine acetyltransferase CSE15_00630 ENOG4105C8N cysteinyl-tRNA synthetase CSE15_00635 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) CSE15_00640 ENOG4105C2N RNA methyltransferase TrmH family group 3 CSE15_00645 ENOG4105M0M Tetracycline resistance protein CSE15_00665 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CSE15_00670 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CSE15_00675 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) CSE15_00680 ENOG4108VZM 50s ribosomal protein L10 CSE15_00685 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CSE15_00690 ENOG4107Y49 methyltransferase CSE15_00695 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CSE15_00700 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CSE15_00705 ENOG4105XPM ribosomal protein CSE15_00710 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CSE15_00715 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CSE15_00720 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CSE15_00730 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CSE15_00735 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CSE15_00740 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CSE15_00745 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CSE15_00750 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CSE15_00755 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CSE15_00760 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CSE15_00765 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CSE15_00770 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CSE15_00775 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CSE15_00780 ENOG41082SA 50s ribosomal protein l29 CSE15_00785 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CSE15_00790 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CSE15_00795 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) CSE15_00800 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CSE15_00805 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CSE15_00810 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CSE15_00815 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CSE15_00820 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CSE15_00825 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CSE15_00830 ENOG4105VPB 50S ribosomal protein L30 CSE15_00835 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CSE15_00840 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CSE15_00845 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CSE15_00850 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CSE15_00860 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CSE15_00870 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CSE15_00875 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CSE15_00880 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CSE15_00885 ENOG4108ZT0 50S ribosomal protein l17 CSE15_00890 ENOG4108JJB ABC transporter CSE15_00895 ENOG4108JJB ABC transporter CSE15_00900 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CSE15_00905 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CSE15_00910 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CSE15_00915 ENOG4108UJD 30S ribosomal protein S9 CSE15_00965 ENOG4108UJD 30S ribosomal protein S9 CSE15_01000 ENOG4105D1F ATP-binding protein CSE15_01015 ENOG4108NMV polysaccharide deacetylase CSE15_01045 ENOG4105I03 Flagellin CSE15_01050 ENOG4105CHH sulfate transporter CSE15_01060 ENOG4105EHZ conserved protein UCP016719 CSE15_01065 ENOG4105D17 glycoside hydrolase, family 3 domain protein CSE15_01085 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CSE15_01120 ENOG4105EMN RNA polymerase sigma factor CSE15_01130 ENOG4105C8B TIGR00159 family CSE15_01135 ENOG4107U5W ybbr family CSE15_01140 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CSE15_01145 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CSE15_01160 ENOG4105DA5 (ABC) transporter CSE15_01170 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) CSE15_01175 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CSE15_01180 ENOG4105U3E Transcriptional regulator CSE15_01190 ENOG4108WUZ (ABC) transporter CSE15_01235 ENOG4105VZ8 Transcriptional regulator CSE15_01245 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) CSE15_01255 ENOG4105YA8 Transcriptional regulator CSE15_01275 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CSE15_01280 ENOG4105CXY transporter CSE15_01295 ENOG4105C7Z Conserved Protein CSE15_01315 ENOG4105C7Z Conserved Protein CSE15_01325 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CSE15_01345 ENOG4105WAB arsR family transcriptional regulator CSE15_01360 ENOG4105XTG Pfam:DUF156 CSE15_01365 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CSE15_01375 ENOG4105VFE sira family CSE15_01380 ENOG4107TPS domain protein CSE15_01385 ENOG4105VFE sira family CSE15_01390 ENOG41087NI Sulfite exporter TauE/SafE CSE15_01395 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) CSE15_01400 ENOG4108SUT Major Facilitator Superfamily CSE15_01425 ENOG4105EWC Purine nucleoside phosphorylase CSE15_01445 ENOG4107SCQ Iron-containing alcohol dehydrogenase CSE15_01450 ENOG4105C72 UPF0176 protein CSE15_01455 ENOG4107QTZ amino acid CSE15_01465 ENOG4105CID antiterminator CSE15_01470 ENOG4105C5Y PTS System CSE15_01475 ENOG4105CS2 ec 3.2.1.21 CSE15_01490 ENOG4105EMD TRANSCRIPTIONal CSE15_01495 ENOG4105EVU fructokinase CSE15_01500 ENOG4105C8I hydrolase, family 38 CSE15_01505 ENOG4105DM4 PTS System CSE15_01510 ENOG4108YRF PTS System CSE15_01515 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein CSE15_01520 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CSE15_01535 ENOG4108IQI permease CSE15_01540 ENOG4108J5H Homocysteine s-methyltransferase CSE15_01545 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CSE15_01560 ENOG4105C2C drug resistance transporter, Bcr CflA CSE15_01580 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin CSE15_01590 ENOG4105J7D transcriptional regulator CSE15_01600 ENOG4105E2A Dehydrogenase CSE15_01605 ENOG41067TZ transcriptional regulator, MarR family CSE15_01615 ENOG4105CUB amino acid CSE15_01630 ENOG4105D74 hydrolase CSE15_01640 ENOG4105CSV Glutaminase CSE15_01655 ENOG41060AI SEC-C motif CSE15_01665 ENOG4105WH1 Two component transcriptional regulator luxr family CSE15_01670 ENOG4105BZU Histidine kinase CSE15_01680 ENOG4107SET aldo keto reductase CSE15_01690 ENOG4107Y7X LytTR CSE15_01695 ENOG4108IUW ABC transporter CSE15_01700 ENOG4108SDH ABC, transporter CSE15_01725 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CSE15_01740 ENOG4108N0M stress protein CSE15_01745 ENOG4106FN3 tellurium resistance protein CSE15_01750 ENOG4106FN3 tellurium resistance protein CSE15_01755 ENOG4107TS3 membrane protein, TerC CSE15_01780 ENOG4108TTB tellurium resistance protein CSE15_01790 ENOG4108IJ7 Glycine betaine CSE15_01795 ENOG4107SQ8 Glycine betaine CSE15_01825 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CSE15_01845 ENOG4105TRI Hydrolase CSE15_01885 ENOG4105EIG urea carboxylase-associated protein 1 CSE15_01890 ENOG4107RMH nh(3)-dependent nad( ) synthetase CSE15_01905 ENOG4105FF2 Type I DHQase CSE15_01910 ENOG4105C7K acetolactate synthase CSE15_01920 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F CSE15_01925 ENOG4105DJB Major Facilitator Superfamily CSE15_01935 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region CSE15_01940 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CSE15_01945 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CSE15_01955 ENOG41079KZ Major Facilitator Superfamily CSE15_01960 ENOG41089UC methyltransferase, type 11 CSE15_01965 ENOG4105C5Q Transcriptional regulator CSE15_01970 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CSE15_01975 ENOG4105I82 acetyl xylan esterase CSE15_01985 ENOG410756H nucleotidyltransferase CSE15_01995 ENOG4105C26 Dehydrogenase CSE15_02000 ENOG4107YHD transcriptional regulator CSE15_02015 ENOG4105E5Q amino acid AbC transporter CSE15_02020 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein CSE15_02030 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein CSE15_02040 ENOG4108AQF aminoglycoside N(3)-acetyltransferase CSE15_02050 ENOG4105C8Q Methyl-accepting chemotaxis CSE15_02080 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CSE15_02085 ENOG4105F38 ABC transporter, permease CSE15_02095 ENOG4105CEY Amp-dependent synthetase and ligase CSE15_02125 ENOG4108IUW ABC transporter CSE15_02135 ENOG4105SX7 Transporter CSE15_02150 ENOG41086D8 Transcriptional regulator CSE15_02165 ENOG4105CDA abc transporter atp-binding protein CSE15_02170 ENOG4105DRP amino acid AbC transporter CSE15_02185 ENOG4108IQI permease CSE15_02190 ENOG4105DUX Transporter CSE15_02200 ENOG4105CPU Monooxygenase CSE15_02205 ENOG4108XSB acetyltransferase, (GNAT) family CSE15_02210 ENOG4105EAB amino acid AbC transporter CSE15_02215 ENOG4108HW4 amino acid AbC transporter CSE15_02225 ENOG4105CH2 amidohydrolase CSE15_02230 ENOG4108PGP mmge prpd family protein CSE15_02260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSE15_02265 ENOG4105BZU Histidine kinase CSE15_02275 ENOG4105CFH Aspartokinase CSE15_02285 ENOG4105R8C Transcriptional regulator CSE15_02295 ENOG4105YVS arsR family transcriptional regulator CSE15_02305 ENOG4105EGI Transcriptional regulator CSE15_02315 ENOG4108JPW Aminotransferase CSE15_02320 ENOG4107QTZ amino acid CSE15_02325 ENOG4105C26 Dehydrogenase CSE15_02330 ENOG4105DYS nad(p)h dehydrogenase (quinone) CSE15_02335 ENOG4105KTB nuclear export factor GLE1 CSE15_02340 ENOG4108T5E Copper resistance protein CSE15_02355 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase CSE15_02360 ENOG4105C8Q Methyl-accepting chemotaxis CSE15_02400 ENOG4105X3H Excalibur domain protein CSE15_02410 ENOG4105E7W lamb ycsf family protein CSE15_02415 ENOG4105C5A transporter CSE15_02420 ENOG4105CFM UPF0317 protein CSE15_02425 ENOG4105P4J Allophanate hydrolase, subunit 1 CSE15_02435 ENOG4107258 Transcriptional regulator CSE15_02440 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CSE15_02445 ENOG4105XJB lipolytic protein G-D-S-L family CSE15_02455 ENOG4105ETD TRANSCRIPTIONal CSE15_02460 ENOG4105HMZ Methyltransferase CSE15_02465 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CSE15_02470 ENOG410606W general stress protein CSE15_02495 ENOG4105VCH membrane CSE15_02500 ENOG4105DRR Transcriptional regulator, GntR family CSE15_02505 ENOG4106AXJ AraC family transcriptional regulator CSE15_02510 ENOG410631K Membrane CSE15_02515 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CSE15_02520 ENOG4105C9U ATP-dependent DNA helicase RecQ CSE15_02535 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) CSE15_02540 ENOG4107R8N Glycosyl transferase, family 2 CSE15_02585 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CSE15_02590 ENOG4107BMA Transglycosylase associated protein CSE15_02595 ENOG4105EU9 CSE15_02600 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CSE15_02605 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CSE15_02610 ENOG4108MRH transcriptional regulatory protein CSE15_02615 ENOG4107QJT sodium dicarboxylate symporter CSE15_02620 ENOG4106F5Q Membrane CSE15_02630 ENOG4105CJ1 ABC, transporter CSE15_02650 ENOG4105SZ6 Thioredoxin CSE15_02655 ENOG4105CPF Cell wall formation (By similarity) CSE15_02660 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CSE15_02675 ENOG4105C1J atp-dependent rna helicase CSE15_02680 ENOG410905X membrane-flanked domain protein CSE15_02685 ENOG4105CKV Membrane CSE15_02700 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CSE15_02705 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CSE15_02715 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CSE15_02720 ENOG4107MMM Anti-sigma-factor antagonist CSE15_02725 ENOG4105FUA antagonist CSE15_02730 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase CSE15_02735 ENOG4107SGM protein serine threonine phosphatase CSE15_02740 ENOG4105WN5 stage II sporulation protein CSE15_02745 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CSE15_02755 ENOG41064BQ Phosphatase CSE15_02775 ENOG4107RUY (E1 component), alpha subunit CSE15_02785 ENOG4107QKR Dehydrogenase CSE15_02795 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CSE15_02840 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase CSE15_02860 ENOG4105RHY Pfam:UPF0157 CSE15_02865 ENOG4105VEQ Cold shock protein CSE15_02870 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CSE15_02880 ENOG4105DQ4 alcohol dehydrogenase CSE15_02885 ENOG4105VUF Transcriptional regulator CSE15_02895 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CSE15_02920 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSE15_02935 ENOG4107GJV short-chain dehydrogenase reductase CSE15_02945 ENOG4107RB3 L-asparaginase CSE15_02950 ENOG4106HB6 Alpha beta hydrolase CSE15_02985 ENOG4105Z7P Acetyltransferase (GNAT) family CSE15_03000 ENOG4105VDT -acetyltransferase CSE15_03005 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase CSE15_03015 ENOG4105ST3 Transcriptional regulator CSE15_03020 ENOG4105NAE bifunctional deaminase-reductase domain protein CSE15_03025 ENOG41090MY MarR family Transcriptional regulator CSE15_03030 ENOG4108TVJ Nitroreductase CSE15_03045 ENOG4108JCI Transcriptional regulator CSE15_03050 ENOG4108VP3 Lysine exporter protein (LysE YggA) CSE15_03055 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) CSE15_03075 ENOG4108UMN azlc family CSE15_03130 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CSE15_03135 ENOG4105K8N protein family UPF0079, ATPase CSE15_03140 ENOG41072GX Peptidase M22 Glycoprotease CSE15_03145 ENOG410801F ribosomal-protein-alanine acetyltransferase CSE15_03150 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CSE15_03160 ENOG4105C5H ABC transporter CSE15_03165 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CSE15_03170 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) CSE15_03175 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CSE15_03180 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CSE15_03195 ENOG4108TYN CAAX amino terminal protease family protein CSE15_03200 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CSE15_03205 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CSE15_03210 ENOG4108U05 Transcriptional regulator CSE15_03220 ENOG4108VXD carboxy-peptidase CSE15_03260 ENOG4107STQ Multicopper oxidase CSE15_03265 ENOG4105C85 amino acid CSE15_03275 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CSE15_03290 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CSE15_03295 ENOG4108UIN ybak prolyl-trna synthetase associated region CSE15_03305 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CSE15_03325 ENOG4105KNA -acetyltransferase CSE15_03340 ENOG4105JVQ RNA Polymerase CSE15_03350 ENOG4108RWP Major Facilitator Superfamily protein CSE15_03355 ENOG4105GZI Transcriptional regulator CSE15_03360 ENOG4105C7N Xanthine uracil vitamin C permease CSE15_03375 ENOG4108U5N UPF0316 protein CSE15_03385 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CSE15_03390 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CSE15_03395 ENOG4105C83 adenylosuccinate lyase CSE15_03400 ENOG4105C8V SAICAR synthetase CSE15_03405 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CSE15_03415 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CSE15_03425 ENOG4105CXB phosphoribosylaminoimidazole synthetase CSE15_03430 ENOG4108V3E phosphoribosylglycinamide formyltransferase CSE15_03435 ENOG4105DC1 bifunctional purine biosynthesis protein purh CSE15_03440 ENOG4105C12 Phosphoribosylglycinamide synthetase CSE15_03460 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CSE15_03475 ENOG4107S4Y M20 DapE family protein YgeY CSE15_03490 ENOG4105KGF protein, YerC YecD CSE15_03500 ENOG4105CBC glutamate synthase CSE15_03515 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) CSE15_03520 ENOG4105C4R Atp-dependent dna helicase CSE15_03525 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CSE15_03540 ENOG4105CRN Aminoglycoside phosphotransferase CSE15_03545 ENOG4105KT7 mgtC SapB transporter CSE15_03550 ENOG4105CK7 Sodium proline symporter CSE15_03555 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CSE15_03560 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CSE15_03565 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CSE15_03570 ENOG4108IG5 Transcriptional regulator CSE15_03580 ENOG4105DU0 nucleoside hydrolase CSE15_03585 ENOG4105CBD Diacylglycerol kinase CSE15_03590 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CSE15_03610 ENOG41062ES Transcriptional regulator CSE15_03615 ENOG4105C3M thioredoxin reductase CSE15_03630 ENOG4105F8D glycoside hydrolase family 4 CSE15_03635 ENOG4105HX0 Transcriptional regulator CSE15_03660 ENOG4108R1P CSE15_03670 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CSE15_03680 ENOG41090R9 glycosyltransferase CSE15_03685 ENOG4107R51 Glycosyl transferase, family 2 CSE15_03690 ENOG41090R9 glycosyltransferase CSE15_03695 ENOG4105EU0 Major facilitator Superfamily CSE15_03700 ENOG4107RVG penicillin-binding protein CSE15_03705 ENOG4105C8P )-transporter CSE15_03735 ENOG4105CUB amino acid CSE15_03740 ENOG4107TVC Glycosyl transferase, family 2 CSE15_03745 ENOG4105C5H ABC transporter CSE15_03750 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) CSE15_03755 ENOG4107SWG transcriptional regulator MERR family CSE15_03760 ENOG4105DXB Major Facilitator superfamily CSE15_03765 ENOG4105C5H ABC transporter CSE15_03770 ENOG4105FDU atp-dependent rna helicase CSE15_03775 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CSE15_03795 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CSE15_03800 ENOG4105E6M Sulphatase-modifying factor protein CSE15_03810 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CSE15_03825 ENOG4108MRH transcriptional regulatory protein CSE15_03845 ENOG4105PY6 Phenolic acid decarboxylase CSE15_03850 ENOG4105U3E Transcriptional regulator CSE15_03865 ENOG41084AG Acylphosphatase CSE15_03870 ENOG4108RPX mosc domain containing protein CSE15_03885 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) CSE15_03895 ENOG4105NX3 Membrane CSE15_03915 ENOG4105DY8 decarboxylase CSE15_03920 ENOG4105C8Q Methyl-accepting chemotaxis CSE15_03930 ENOG4105C5Y PTS System CSE15_03935 ENOG4105CG3 alpha amylase, catalytic region CSE15_03940 ENOG4107414 GntR family transcriptional regulator CSE15_03950 ENOG4105CGH 5'-nucleotidase CSE15_03955 ENOG4107RKG DJ-1/PfpI family CSE15_03975 ENOG4105KJF protein tyrosine phosphatase CSE15_03985 ENOG4107U9T Pfam:Ribonuclease_BN CSE15_03990 ENOG4108Z9I -acetyltransferase CSE15_03995 ENOG4108ISG Major Facilitator CSE15_04005 ENOG4105UPD Calcium Proton CSE15_04020 ENOG4105CDY transcriptional regulatory protein CSE15_04030 ENOG4105D8X mechanosensitive ion channel CSE15_04055 ENOG4105D7N magnesium and cobalt transport protein CorA CSE15_04070 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CSE15_04085 ENOG4107V2S Transcriptional regulator CSE15_04090 ENOG4105MDS 4-oxalocrotonate tautomerase CSE15_04095 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase CSE15_04100 ENOG4107TXC Transcriptional regulator CSE15_04120 ENOG4105C22 threonyL-tRNA synthetase CSE15_04175 ENOG410839T multidrug resistance protein CSE15_04195 ENOG4107TDE lipolytic protein G-D-S-L family CSE15_04210 ENOG4108HUF Transporter CSE15_04215 ENOG4105BZ1 (ABC) transporter CSE15_04220 ENOG4105KK4 UPF0060 membrane protein CSE15_04225 ENOG4105K6V RNA polymerase CSE15_04245 ENOG4108YYS metal-dependent hydrolase (By similarity) CSE15_04255 ENOG410834F Transcriptional regulator CSE15_04280 ENOG4107Y03 Nitroreductase CSE15_04295 ENOG4105ECP epimerase CSE15_04300 ENOG4105KC9 Modulates RecA activity (By similarity) CSE15_04325 ENOG4105CKK Glycosyl transferase, family 2 CSE15_04330 ENOG4105EJV Membrane CSE15_04335 ENOG4105MSY salicylate hydroxylase CSE15_04350 ENOG4105F0F Oxalate decarboxylase CSE15_04360 ENOG4106DF4 Sigma-70, region 4 CSE15_04370 ENOG41067AE Membrane-bound metal-dependent hydrolase CSE15_04375 ENOG4105CEN a g-specific adenine glycosylase CSE15_04380 ENOG4106BXE CSE15_04385 ENOG4105CAN Short-chain dehydrogenase reductase Sdr CSE15_04400 ENOG4105EVI UPF0374 protein CSE15_04410 ENOG4105C3U ABC transporter CSE15_04415 ENOG4108JQ7 (ABC) transporter CSE15_04420 ENOG4105DEF Extracellular solute-binding protein, family 5 CSE15_04425 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSE15_04430 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSE15_04435 ENOG4107NBY Membrane CSE15_04440 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CSE15_04445 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CSE15_04450 ENOG4105G5W regulator Fur family CSE15_04600 ENOG4105E0M Sulfatase CSE15_04620 ENOG4105E2Y ABC, transporter CSE15_04625 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein CSE15_04630 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CSE15_04635 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CSE15_04645 ENOG4105CJ1 ABC, transporter CSE15_04680 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CSE15_04690 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CSE15_04695 ENOG4105CYN Serine protein kinase CSE15_04700 ENOG4106AKX UPF0229 protein CSE15_04705 ENOG4105CW7 secretion protein, HlyD family CSE15_04710 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSE15_04715 ENOG4105CS1 NAD(P)H quinone oxidoreductase CSE15_04725 ENOG4105VEQ Cold shock protein CSE15_04735 ENOG4105BZU Histidine kinase CSE15_04765 ENOG4105BZU Histidine kinase CSE15_04780 ENOG4108YBP pseudouridine synthase CSE15_04790 ENOG4107YBY Hydrolase CSE15_04795 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CSE15_04815 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR CSE15_04820 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CSE15_04825 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CSE15_04835 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CSE15_04840 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CSE15_04850 ENOG4105BZU Histidine kinase CSE15_04855 ENOG4105WH1 Two component transcriptional regulator luxr family CSE15_04870 ENOG4105CH6 catalase CSE15_04875 ENOG4105KPV Transcriptional regulator CSE15_04880 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CSE15_04890 ENOG4105G6Z alkaline phosphatase CSE15_04900 ENOG4105CUB amino acid CSE15_04910 ENOG4105J37 CSE15_04915 ENOG4108AEY RNA polymerase sigma factor CSE15_04920 ENOG4105F6E Acyl-transferase CSE15_04925 ENOG4105C37 (CBS) domain CSE15_04935 ENOG4105C37 (CBS) domain CSE15_04945 ENOG4106A8V Protein CrcB homolog CSE15_04950 ENOG4105WMR Protein CrcB homolog CSE15_04955 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CSE15_04965 ENOG4105D64 Mechanosensitive ion channel CSE15_04970 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CSE15_04975 ENOG4107VMI polysaccharide deacetylase CSE15_04980 ENOG4105F0I Aminotransferase CSE15_04990 ENOG4105BZ1 (ABC) transporter CSE15_04995 ENOG4105BZ1 (ABC) transporter CSE15_05025 ENOG410839P CSE15_05035 ENOG4108UH6 UPF0754 membrane protein CSE15_05040 ENOG4105WZB UPF0342 protein CSE15_05050 ENOG4105D4P Coproporphyrinogen iii oxidase CSE15_05060 ENOG4107S91 Sodium hydrogen exchanger CSE15_05065 ENOG4105NCW Trka-c domain protein CSE15_05075 ENOG4105CGU Enoyl-CoA hydratase CSE15_05085 ENOG4107VRP DNA repair exonuclease CSE15_05090 ENOG4106D4I domain protein CSE15_05105 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CSE15_05150 ENOG4105NBU tryptophan transport protein CSE15_05155 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CSE15_05160 ENOG4105K59 histidine triad (HIT) protein CSE15_05190 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CSE15_05195 ENOG4105BZ4 penicillin-binding protein CSE15_05200 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CSE15_05205 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CSE15_05210 ENOG4105C1Q protoporphyrinogen oxidase CSE15_05220 ENOG4105ECB domain protein CSE15_05230 ENOG4105DER m42 family CSE15_05240 ENOG4106AXD CSE15_05245 ENOG4108RQ5 Beta-lactamase domain-containing protein CSE15_05250 ENOG4105DF9 Lipoate-protein, ligase CSE15_05255 ENOG4105CEY Amp-dependent synthetase and ligase CSE15_05270 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CSE15_05275 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CSE15_05280 ENOG4107TB6 phosphoglycerate mutase CSE15_05285 ENOG4106YBV Methyl-accepting chemotaxis CSE15_05305 ENOG4105XVF Competence transcription factor CSE15_05325 ENOG4105C0R drug resistance transporter emrb qaca subfamily CSE15_05330 ENOG41067XF inhibitor CSE15_05335 ENOG4105DHS permease protein CSE15_05340 ENOG4105CM4 permease protein CSE15_05345 ENOG4108IPW abc transporter atp-binding protein CSE15_05355 ENOG4108KGH TRANSCRIPTIONal CSE15_05365 ENOG41060YP CSE15_05380 ENOG4108KK1 membrane protein AbrB duplication CSE15_05420 ENOG4105EYH Exonuclease CSE15_05480 ENOG4105ERH Fumarylacetoacetate hydrolase CSE15_05485 ENOG4106BKT UPF0344 protein CSE15_05495 ENOG4105CAQ asparagine synthetase CSE15_05520 ENOG4105UQX Mate efflux family protein CSE15_05525 ENOG4106HBX Transcriptional Regulator AraC Family CSE15_05550 ENOG4105DY8 decarboxylase CSE15_05595 ENOG4108VPT UPF0234 protein CSE15_05600 ENOG4105QNR S1 RNA binding domain protein CSE15_05610 ENOG4105DIH basic membrane CSE15_05615 ENOG4105C8Q Methyl-accepting chemotaxis CSE15_05620 ENOG4105EPR degv family CSE15_05625 ENOG4107AYK membrAne CSE15_05635 ENOG41073B9 CSE15_05645 ENOG4108KP7 hydrolase CSE15_05650 ENOG4108MXZ Esterase CSE15_05655 ENOG4105VG1 fes assembly suf system protein CSE15_05660 ENOG4105IQ5 FAD linked oxidase domain protein CSE15_05670 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CSE15_05680 ENOG4105CAS nag kinase CSE15_05685 ENOG4105C8Y Acetylornithine aminotransferase CSE15_05690 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CSE15_05700 ENOG4105DBV ornithine carbamoyltransferase CSE15_05730 ENOG4107RMD Basic membrane lipoprotein CSE15_05745 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CSE15_05750 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CSE15_05760 ENOG4105C3U ABC transporter CSE15_05765 ENOG4108JQ7 (ABC) transporter CSE15_05780 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSE15_05790 ENOG4105C31 Tryptophanyl-tRNA synthetase CSE15_05795 ENOG4108J59 Extracellular solute-binding protein, family 5 CSE15_05800 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSE15_05805 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSE15_05815 ENOG4108JQ7 (ABC) transporter CSE15_05830 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) CSE15_05835 ENOG4108ZCF integral membrane protein CSE15_05840 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis CSE15_05845 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CSE15_05855 ENOG4105DPN Oligoendopeptidase f CSE15_05865 ENOG4105T58 Dithiol-disulfide isomerase CSE15_05870 ENOG4108Z18 K06886 hemoglobin CSE15_05875 ENOG4105E4C Lytic transglycosylase catalytic CSE15_05880 ENOG4105MIX Adenylate cyclase CSE15_05885 ENOG4106EFP UPF0738 protein CSE15_05895 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CSE15_05900 ENOG4105EMS pseudouridine synthase CSE15_05905 ENOG4107S1Q Phosphatase CSE15_05915 ENOG4105ETU transcriptional activator (TenA CSE15_05920 ENOG4108VEU Thiamine monophosphate synthase CSE15_05935 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CSE15_05940 ENOG4105D06 uba thif-type nad fad binding protein CSE15_05945 ENOG4105DWF phosphomethylpyrimidine kinase CSE15_05950 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CSE15_05955 ENOG4107A88 CSE15_06030 ENOG4105C28 cystathionine CSE15_06035 ENOG4105C28 cystathionine CSE15_06095 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CSE15_06115 ENOG4105DJ2 Major Facilitator Superfamily CSE15_06165 ENOG4105DUM transcriptional regulator, lysR family CSE15_06185 ENOG4107V2S Transcriptional regulator CSE15_06190 ENOG4105DJ2 Major Facilitator Superfamily CSE15_06225 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CSE15_06235 ENOG4105PF9 Transcriptional regulator CSE15_06245 ENOG4105I03 Flagellin CSE15_06250 ENOG4105I03 Flagellin CSE15_06270 ENOG4105K7W phage-related replication protein CSE15_06275 ENOG410635T phage-like element pbsx protein CSE15_06280 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CSE15_06295 ENOG4105CJ3 phosphate transporter CSE15_06300 ENOG4107GRR phosphate transport regulator CSE15_06310 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CSE15_06315 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein CSE15_06320 ENOG4108I5D sulfate abc transporter CSE15_06325 ENOG4105ECW sulfate abc transporter CSE15_06330 ENOG4108IJ6 ABC transporter CSE15_06340 ENOG4105DT3 PTS system, galactitol-specific IIc component CSE15_06360 ENOG4107RUY (E1 component), alpha subunit CSE15_06365 ENOG4105CPP Dehydrogenase, E1 component CSE15_06370 ENOG4107QKR Dehydrogenase CSE15_06380 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CSE15_06385 ENOG4105CHR reductase CSE15_06390 ENOG4107RHR regulatoR CSE15_06400 ENOG4107R7I amino acid CSE15_06410 ENOG4105C0H protease CSE15_06420 ENOG4108ME1 Peptidase M55 D-aminopeptidase CSE15_06425 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSE15_06430 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSE15_06435 ENOG4105C3U ABC transporter CSE15_06450 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CSE15_06455 ENOG4105DTQ mandelate racemase muconate lactonizing CSE15_06460 ENOG4107SN7 NLP P60 protein CSE15_06465 ENOG4108JQ7 (ABC) transporter CSE15_06470 ENOG4107TUM Amidinotransferase CSE15_06475 ENOG4108S4H thioesterase Superfamily protein CSE15_06480 ENOG4105K7K Transcriptional regulator CSE15_06495 ENOG4108428 Inherit from COG: -acetyltransferase CSE15_06500 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CSE15_06505 ENOG410839T multidrug resistance protein CSE15_06510 ENOG41080TC multidrug resistance protein CSE15_06520 ENOG4105CIY formyltetrahydrofolate deformylase CSE15_06525 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CSE15_06530 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CSE15_06550 ENOG4105K56 Transcriptional regulator CSE15_06555 ENOG4108ZHJ Organic hydroperoxide resistance protein CSE15_06560 ENOG4107Y2X deaminase CSE15_06565 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CSE15_06570 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CSE15_06585 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSE15_06590 ENOG41062D9 Histidine kinase CSE15_06600 ENOG4106849 propeptide, pepSY amd peptidase M4 CSE15_06610 ENOG4105CJW magnesium transporter CSE15_06630 ENOG4105V75 Transcriptional regulator CSE15_06655 ENOG4105BZU Histidine kinase CSE15_06660 ENOG4107T5V SNARE associated Golgi CSE15_06665 ENOG4107TS3 membrane protein, TerC CSE15_06670 ENOG4108WZW RNA polymerase sigma CSE15_06680 ENOG410681C small acid-soluble spore protein CSE15_06690 ENOG4105D0M Protease HtpX homolog CSE15_06700 ENOG410900G Protein of unknown function (DUF421) CSE15_06715 ENOG4108TGC Acyltransferase CSE15_06720 ENOG4105BZU Histidine kinase CSE15_06725 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CSE15_06730 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CSE15_06735 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CSE15_06745 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate CSE15_06750 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) CSE15_06755 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CSE15_06760 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CSE15_06775 ENOG41090MY MarR family Transcriptional regulator CSE15_06780 ENOG4105ER2 Ompa motb domain protein CSE15_06785 ENOG4105E14 MotA TolQ exbB proton channel CSE15_06795 ENOG4108K88 Membrane CSE15_06800 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CSE15_06805 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase CSE15_06810 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CSE15_06815 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CSE15_06840 ENOG4105F0V Cell wall hydrolase CSE15_06855 ENOG4105C59 p-type ATPase CSE15_06860 ENOG4105DC7 peptidase M24 CSE15_06870 ENOG4105CID antiterminator CSE15_06880 ENOG4105KRI phosphocarrier protein (HPr CSE15_06885 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CSE15_06895 ENOG4105F6S Spore photoproduct lyase CSE15_06900 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CSE15_06905 ENOG4105CHR reductase CSE15_06910 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CSE15_06915 ENOG4105K4I Scp-like extracellular CSE15_06925 ENOG4105BZU Histidine kinase CSE15_06930 ENOG4105CHM Aminotransferase CSE15_06940 ENOG41085PJ rdd domain containing protein CSE15_06950 ENOG4107R88 Chemotaxis protein (CheV) CSE15_06955 ENOG4105UIN CSE15_06960 ENOG4108MCI Transcriptional regulator, ARAC family CSE15_06965 ENOG4108UZ3 Transporter CSE15_06985 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein CSE15_06995 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CSE15_07000 ENOG4105EPM Diguanylate phosphodiesterase CSE15_07005 ENOG4105WEF catalase CSE15_07010 ENOG4107IN1 Protein of unknown function (DUF1797) CSE15_07015 ENOG4108XRC Protein of unknown function (DUF458) CSE15_07050 ENOG4105NQC Flavodoxin CSE15_07055 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) CSE15_07065 ENOG4106AUC UPF0180 protein CSE15_07070 ENOG4105D8X mechanosensitive ion channel CSE15_07075 ENOG4105D3R alkyl hydroperoxide reductase CSE15_07080 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CSE15_07095 ENOG41080QG Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CSE15_07105 ENOG4105CVM Molybdenum cofactor synthesis domain protein CSE15_07115 ENOG4108ZAF Molybdopterin CSE15_07120 ENOG41067WU Molybdopterin converting factor (Subunit 1) CSE15_07135 ENOG4107X8C Efflux transporter RND family MFP subunit CSE15_07140 ENOG4105C19 ABC transporter CSE15_07145 ENOG4107RBB ABC transporter, permease CSE15_07150 ENOG4105E98 transcriptional regulator DeoR family CSE15_07155 ENOG4105DE4 1-phosphofructokinase CSE15_07160 ENOG4105DM4 PTS System CSE15_07175 ENOG4105C5H ABC transporter CSE15_07200 ENOG4105BZU Histidine kinase CSE15_07210 ENOG4107ZYR domain protein CSE15_07215 ENOG4105CPN adenine deaminase CSE15_07220 ENOG4105CN5 Metallo-Beta-Lactamase CSE15_07230 ENOG4108X4Q Hydrolase CSE15_07235 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CSE15_07255 ENOG4105CPP Dehydrogenase, E1 component CSE15_07260 ENOG4105C7S Dehydrogenase CSE15_07265 ENOG4107QN2 dihydrolipoyl dehydrogenase CSE15_07280 ENOG4105CXN decarboxylase CSE15_07290 ENOG4108WQ8 UPF0637 protein CSE15_07300 ENOG4105ECY inositol monophosphatase CSE15_07335 ENOG4105CI3 gtp-binding protein typa CSE15_07340 ENOG4105QA2 CSE15_07355 ENOG4108IAB Phoh family CSE15_07375 ENOG4105CNI cell division protein FtsW CSE15_07380 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CSE15_07385 ENOG4105CVP deoxyribo-dipyrimidine photolyase CSE15_07395 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CSE15_07405 ENOG4105BZ9 Cytochrome C oxidase, subunit I CSE15_07410 ENOG4105CCU oxidase (Subunit III) CSE15_07415 ENOG41064X9 cytochrome C oxidase subunit IV CSE15_07430 ENOG41080XQ Signal transduction protein with cbs domains CSE15_07435 ENOG4106UY4 Inherit from COG: Scp-like extracellular CSE15_07460 ENOG4105WUC UPF0298 protein CSE15_07465 ENOG4106H78 methyltransferase CSE15_07470 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CSE15_07475 ENOG4105H20 Sporulation integral membrane protein YlbJ CSE15_07480 ENOG4105D78 K07001 NTE family protein CSE15_07485 ENOG41063PX domain protein CSE15_07490 ENOG4105CDE UPF0348 protein CSE15_07495 ENOG4105KNH Nucleic acid-binding protein CSE15_07500 ENOG41067VY 50S ribosomal protein L32 CSE15_07525 ENOG4108V6E Cell division protein mraZ CSE15_07530 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CSE15_07540 ENOG4105CJN penicillin-binding protein CSE15_07550 ENOG4105CJN penicillin-binding protein CSE15_07555 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CSE15_07560 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CSE15_07565 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CSE15_07570 ENOG4105CNI cell division protein FtsW CSE15_07575 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CSE15_07580 ENOG4105D4A Cell wall formation (By similarity) CSE15_07585 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) CSE15_07590 ENOG4108R2U division initiation protein CSE15_07600 ENOG4105K67 small basic protein CSE15_07605 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CSE15_07610 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CSE15_07620 ENOG4105FFI sigma-e processing peptidase spoiiga CSE15_07625 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSE15_07635 ENOG4105DKT Transcriptional regulator CSE15_07650 ENOG410787A Pts system, glucitol sorbitol-specific CSE15_07655 ENOG4105DZY Pts system, glucitol sorbitol-specific CSE15_07660 ENOG4105VI0 Pts system, glucitol sorbitol-specific CSE15_07665 ENOG4105DKW ABC transporter CSE15_07670 ENOG4105WR5 sporulation protein, YlmC YmxH family CSE15_07675 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CSE15_07680 ENOG4105DFA alanine racemase domain protein CSE15_07685 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CSE15_07690 ENOG41067XK integral membrane protein CSE15_07695 ENOG4105DBK s4 domain protein CSE15_07705 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CSE15_07715 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CSE15_07720 ENOG4105C34 Pseudouridine synthase CSE15_07725 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CSE15_07735 ENOG4105CXT aspartate transcarbamylase CSE15_07740 ENOG4105CD3 dihydroorotase CSE15_07745 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CSE15_07750 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CSE15_07755 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CSE15_07760 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) CSE15_07765 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CSE15_07770 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CSE15_07780 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CSE15_07790 ENOG4107RIQ Sulfate adenylate transferase CSE15_07795 ENOG4108WF4 Catalyzes the synthesis of activated sulfate (By similarity) CSE15_07800 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CSE15_07805 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CSE15_07810 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CSE15_07815 ENOG4105F23 Fibronectin-binding protein CSE15_07825 ENOG4105DSJ YicC domain protein CSE15_07830 ENOG4105KC4 UPF0296 protein CSE15_07835 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CSE15_07845 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CSE15_07850 ENOG4105C25 Primosomal protein n' CSE15_07855 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CSE15_07860 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CSE15_07865 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CSE15_07870 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CSE15_07875 ENOG4108ZF3 Phosphatase CSE15_07880 ENOG4105D9P serine threonine protein kinase CSE15_07885 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CSE15_07890 ENOG4105DJV ribulose-phosphate 3-epimerase CSE15_07895 ENOG4105FJ0 thiamine CSE15_07905 ENOG4105VB9 50S ribosomal protein l28 CSE15_07910 ENOG4108ZAA Alkaline-shock protein CSE15_07915 ENOG4105DP4 dak2 domain fusion protein ylov CSE15_07925 ENOG4105EJQ L-serine dehydratase CSE15_07930 ENOG4105CB5 ATP-dependent DNA helicase recG CSE15_07935 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) CSE15_07940 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CSE15_07945 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CSE15_07950 ENOG4105CHR reductase CSE15_07955 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CSE15_07960 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CSE15_07965 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CSE15_07970 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CSE15_07980 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) CSE15_07990 ENOG4105K5M 30s ribosomal protein S16 CSE15_07995 ENOG4108BW8 UPF0109 protein CSE15_08005 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CSE15_08010 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CSE15_08015 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CSE15_08020 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CSE15_08025 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CSE15_08035 ENOG4105VM1 flagellar CSE15_08040 ENOG4105CMV Succinyl-CoA synthetase subunit beta CSE15_08045 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CSE15_08050 ENOG4105C79 DNA protecting protein DprA CSE15_08055 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CSE15_08060 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) CSE15_08065 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CSE15_08070 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CSE15_08075 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CSE15_08085 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CSE15_08090 ENOG4108ZC9 flagellar basal-body rod protein flgc CSE15_08095 ENOG4105VQ0 flagellar hook-basal body complex protein fliE CSE15_08100 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CSE15_08105 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CSE15_08120 ENOG4106YF4 Flagellar biosynthesis chaperone CSE15_08130 ENOG410696Y Flagellar hook-length control protein CSE15_08135 ENOG410822I Flagellar hook capping protein CSE15_08140 ENOG4108JQA flagellar CSE15_08145 ENOG41068WV flagellar FlbD family protein CSE15_08155 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CSE15_08160 ENOG4105DD5 Flagellar motor switch protein CSE15_08165 ENOG4107YTP response regulator receiver protein CSE15_08175 ENOG4105CN7 Flagellar biosynthetic protein FliP CSE15_08180 ENOG4105VS8 Flagellar biosynthetic protein fliq CSE15_08185 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CSE15_08190 ENOG4105D00 flagellar biosynthetic protein flhB CSE15_08195 ENOG4105D7B Flagellar biosynthesis protein flha CSE15_08210 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) CSE15_08215 ENOG4105CBS Chea signal transduction histidine kinase CSE15_08220 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis CSE15_08230 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) CSE15_08235 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSE15_08245 ENOG4105CE9 30S ribosomal protein S2 CSE15_08250 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CSE15_08260 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CSE15_08265 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CSE15_08270 ENOG4105KNE Phosphatidate cytidylyltransferase CSE15_08275 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) CSE15_08280 ENOG4105DZP Membrane-associated zinc metalloprotease CSE15_08285 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CSE15_08305 ENOG4105WJF CSE15_08320 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) CSE15_08325 ENOG4105CHV Transcription elongation factor NusA CSE15_08330 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CSE15_08335 ENOG4105VHM ribosomal protein CSE15_08340 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CSE15_08345 ENOG4105W7A Protein of unknown function (DUF503) CSE15_08350 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CSE15_08355 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CSE15_08360 ENOG4105DTN riboflavin biosynthesis protein ribF CSE15_08365 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CSE15_08370 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CSE15_08380 ENOG4105C1V Peptidase, M16 CSE15_08395 ENOG4105E35 Dipicolinate synthase subunit A CSE15_08400 ENOG4108S0H Dipicolinic acid synthetase, b subunit CSE15_08405 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CSE15_08415 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CSE15_08425 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CSE15_08435 ENOG4105CNU cell division protein FtsK CSE15_08440 ENOG4105FDP GntR family transcriptional regulator CSE15_08450 ENOG4105EYF MMPL domain protein CSE15_08470 ENOG4105EYF MMPL domain protein CSE15_08475 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CSE15_08480 ENOG4105XZV Protein of unknown function (DUF3243) CSE15_08495 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CSE15_08500 ENOG4105CEV competence damage-inducible protein CSE15_08505 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CSE15_08510 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) CSE15_08515 ENOG4105D48 metallophosphoesterase CSE15_08520 ENOG4105MCT stage V sporulation protein S CSE15_08530 ENOG4105CPQ Dehydrogenase CSE15_08535 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CSE15_08540 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CSE15_08555 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CSE15_08580 ENOG4108VJ1 Transcriptional regulator (CarD family CSE15_08585 ENOG4105K7W phage-related replication protein CSE15_08595 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CSE15_08600 ENOG4105K7W phage-related replication protein CSE15_08605 ENOG4108X3M OsmC Ohr family protein CSE15_08610 ENOG410814C multidrug resistance protein CSE15_08635 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CSE15_08655 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CSE15_08660 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CSE15_08665 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CSE15_08670 ENOG4105U6W MutT NUDIX family protein CSE15_08680 ENOG4106F1P AAA ATPase, central domain protein CSE15_08685 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CSE15_08690 ENOG4105CXI aluminum resistance protein CSE15_08695 ENOG4105KV4 Transcriptional regulator CSE15_08700 ENOG4105C5F glutamine synthetase CSE15_08720 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) CSE15_08725 ENOG410780I phosphoprotein phosphatase activity CSE15_08770 ENOG4108ZMX Domain of unknown function (DU1801) CSE15_08790 ENOG410780I phosphoprotein phosphatase activity CSE15_08800 ENOG4105XPP Protein of unknown function (DUF1275) CSE15_08805 ENOG4105DQE DNA ligase CSE15_08810 ENOG4105FDF Could be involved in DNA repair (By similarity) CSE15_08815 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) CSE15_08825 ENOG4108Z40 Transcriptional regulator CSE15_08830 ENOG4105ECR NmrA family CSE15_08840 ENOG4107R5T Cysteine-rich domain CSE15_08845 ENOG4107QR9 Iron-sulfur cluster binding protein CSE15_08850 ENOG41080R8 Conserved Protein CSE15_08875 ENOG4108QY0 Membrane CSE15_08880 ENOG41082JN Transcriptional regulator CSE15_08885 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CSE15_08890 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases CSE15_08895 ENOG4105EDW glycosyl transferase, family 39 CSE15_08900 ENOG4105WFK nuclease CSE15_08905 ENOG4106SCS STAS domain CSE15_08930 ENOG4108SVB resolvase CSE15_08935 ENOG4105VPS UPF0291 protein CSE15_08940 ENOG4105CV1 Transketolase (EC 2.2.1.1) CSE15_08950 ENOG4105VXM UPF0154 protein CSE15_08960 ENOG4107QIV Cytochrome c biogenesis protein CSE15_08990 ENOG4108I0Z Aconitate hydratase CSE15_08995 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CSE15_09020 ENOG4105MI2 CSE15_09025 ENOG4105W8X HesB YadR YfhF-family protein CSE15_09030 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CSE15_09035 ENOG4105K4P CoA-binding domain protein CSE15_09040 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CSE15_09055 ENOG4106UW1 Major Facilitator superfamily CSE15_09060 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CSE15_09065 ENOG4108UW5 maltose o-acetyltransferase CSE15_09070 ENOG4108UXE Protein tyrosine phosphatase CSE15_09080 ENOG41082YX Transcriptional regulator, arsr family CSE15_09095 ENOG4107ZXU DSBA oxidoreductase CSE15_09100 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CSE15_09110 ENOG4105ST3 Transcriptional regulator CSE15_09115 ENOG4105DYS nad(p)h dehydrogenase (quinone) CSE15_09120 ENOG4105KVH Transcriptional regulator CSE15_09125 ENOG4105C6T cysteine synthase CSE15_09130 ENOG4105KME endoribonuclease L-psp CSE15_09145 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) CSE15_09175 ENOG4108Z6Z Transcriptional regulator CSE15_09180 ENOG4105CS2 ec 3.2.1.21 CSE15_09205 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CSE15_09215 ENOG4107SYN Glycosyl hydrolases family 43 CSE15_09230 ENOG4105I1K ABC transporter CSE15_09235 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CSE15_09265 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia CSE15_09275 ENOG4105KD7 acetyltransferase CSE15_09280 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CSE15_09325 ENOG4105DM4 PTS System CSE15_09330 ENOG4105DM4 PTS System CSE15_09335 ENOG4105DE4 1-phosphofructokinase CSE15_09340 ENOG4105HX0 Transcriptional regulator CSE15_09345 ENOG4107RZC phospholipase d CSE15_09370 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CSE15_09385 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CSE15_09390 ENOG4107QX3 carboxylase CSE15_09395 ENOG4105E39 Enoyl-CoA hydratase CSE15_09400 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CSE15_09405 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CSE15_09410 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CSE15_09415 ENOG4105CEY Amp-dependent synthetase and ligase CSE15_09420 ENOG4105C1G acyl-Coa dehydrogenase CSE15_09425 ENOG4105F32 YngK protein CSE15_09435 ENOG4105E98 transcriptional regulator DeoR family CSE15_09440 ENOG41090U3 tautomerase CSE15_09455 ENOG4105CQB FAD linked oxidase domain protein CSE15_09460 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CSE15_09470 ENOG4108B31 Spore germination protein CSE15_09490 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CSE15_09495 ENOG4107T5V SNARE associated Golgi CSE15_09500 ENOG4105EXQ uroporphyrinogen iii synthase hem4 CSE15_09525 ENOG4107QJQ Mate efflux family protein CSE15_09530 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family CSE15_09535 ENOG4105NBR Pectinesterase CSE15_09540 ENOG4105H67 Protein of unknown function (DUF421) CSE15_09545 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CSE15_09550 ENOG4108IFG nitrite reductase, (NAD(P)H) CSE15_09555 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CSE15_09570 ENOG4105BZ8 glutamate synthase CSE15_09575 ENOG4105CBC glutamate synthase CSE15_09580 ENOG4105C5Q Transcriptional regulator CSE15_09595 ENOG41090E6 transcriptional regulator MERR family CSE15_09600 ENOG4108UYN gCN5-related N-acetyltransferase CSE15_09605 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) CSE15_09610 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CSE15_09615 ENOG4105II7 pyrroline-5-carboxylate reductase CSE15_09625 ENOG4108J2R molybdopterin oxidoreductase CSE15_09635 ENOG4105CMG Carbohydrate kinase CSE15_09645 ENOG4105E2R ROK family CSE15_09655 ENOG4105CT4 transporter CSE15_09660 ENOG4108Z7R Chaperone CsaA CSE15_09670 ENOG4105FVX CSE15_09690 ENOG4108W8B Beta-lactamase domain protein CSE15_09700 ENOG4105D29 Helix-turn-helix type 11 domain protein CSE15_09710 ENOG4105KTU Transcriptional regulator, arsr family CSE15_09715 ENOG4105CUB amino acid CSE15_09725 ENOG4105CR4 methylisocitrate lyase CSE15_09730 ENOG4105DXD 2-methylcitrate dehydratase CSE15_09750 ENOG41069ER domain protein CSE15_09755 ENOG4105C9U ATP-dependent DNA helicase RecQ CSE15_09765 ENOG4105SCY DNAK suppressor CSE15_09790 ENOG4105C26 Dehydrogenase CSE15_09800 ENOG4105EWU Squalene--hopene cyclase CSE15_09805 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CSE15_09810 ENOG4105C09 Bile acid CSE15_09820 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CSE15_09825 ENOG4107T89 von Willebrand factor, type A CSE15_09830 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CSE15_09840 ENOG4105K4H Nlp p60 protein CSE15_09850 ENOG4107QMU Mate efflux family protein CSE15_09870 ENOG4105FR1 rard protein CSE15_09900 ENOG4105E1V na solute symporter CSE15_09925 ENOG4108VXD carboxy-peptidase CSE15_09930 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CSE15_09935 ENOG4106Z5R CSE15_09940 ENOG410841Q phosphoesterase PA-phosphatase related protein CSE15_09955 ENOG4105VSD UPF0346 protein CSE15_09965 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CSE15_09970 ENOG4108JUB Transcriptional regulator CSE15_10000 ENOG4105C5E polysaccharide biosynthesis protein CSE15_10005 ENOG4105E0X reductase CSE15_10010 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CSE15_10040 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) CSE15_10045 ENOG41090WU lipolytic protein G-D-S-L family CSE15_10050 ENOG4108KF3 Electron transport protein SCO1 SenC CSE15_10065 ENOG4105C7B Threonine dehydratase CSE15_10075 ENOG4108UT2 hemolysin iii CSE15_10085 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CSE15_10090 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CSE15_10105 ENOG4107YX5 Pfam:DUF548 CSE15_10110 ENOG4108Y6J UPF0403 protein CSE15_10115 ENOG4105C01 Dihydroxy-acid dehydratase CSE15_10130 ENOG4108V06 Glutathione peroxidase CSE15_10135 ENOG4105CKU formyltetrahydrofolate synthetase CSE15_10145 ENOG4108QBV Monogalactosyldiacylglycerol synthase CSE15_10180 ENOG41081VK Ribonuclease CSE15_10200 ENOG410890F Dynamin family CSE15_10210 ENOG41065KQ synthase CSE15_10215 ENOG4105RHY Pfam:UPF0157 CSE15_10220 ENOG4107VMI polysaccharide deacetylase CSE15_10225 ENOG4105C2W permease CSE15_10240 ENOG4105CTD carboxy-peptidase CSE15_10245 ENOG4105DVT helicase CSE15_10255 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CSE15_10265 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) CSE15_10270 ENOG4108UKS UPF0398 protein CSE15_10285 ENOG4108I5C dEAD DEAH box helicase CSE15_10290 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CSE15_10330 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) CSE15_10335 ENOG4105BZ4 penicillin-binding protein CSE15_10345 ENOG4105CSM endonuclease III CSE15_10370 ENOG4105YAC CSE15_10375 ENOG4105DVT helicase CSE15_10380 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CSE15_10385 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CSE15_10390 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CSE15_10400 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CSE15_10405 ENOG4105CPK Glycosyl transferase (Group 1 CSE15_10410 ENOG4105FJR Lmbe family CSE15_10415 ENOG4108Z5K methylglyoxal synthase CSE15_10420 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CSE15_10425 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CSE15_10430 ENOG4108JYZ YitT family CSE15_10450 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CSE15_10465 ENOG4108SXZ UPF0302 protein CSE15_10470 ENOG41068YB TPR repeat-containing protein CSE15_10475 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CSE15_10485 ENOG4105CIH Imidazole acetol-phosphate transaminase CSE15_10490 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) CSE15_10495 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CSE15_10500 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase CSE15_10505 ENOG4105DK0 Indole-3-glycerol phosphate synthase CSE15_10510 ENOG4108I0Q anthranilate phosphoribosyltransferase CSE15_10520 ENOG4105KHN chorismate mutase CSE15_10525 ENOG4105D49 3-dehydroquinate synthase CSE15_10530 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CSE15_10535 ENOG4105BZU Histidine kinase CSE15_10540 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CSE15_10545 ENOG4105EAH synthase CSE15_10550 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CSE15_10555 ENOG4105XXQ heptaprenyl diphosphate synthase component I CSE15_10565 ENOG4105EUJ GTP cyclohydrolase i CSE15_10570 ENOG4105K70 DNA-binding protein CSE15_10580 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CSE15_10595 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CSE15_10600 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CSE15_10605 ENOG41065D1 CSE15_10610 ENOG4105S2F CSE15_10635 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CSE15_10640 ENOG4105CAT Cytidine monophosphate kinase CSE15_10655 ENOG4105MSI germination protein ypeb CSE15_10665 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) CSE15_10670 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CSE15_10685 ENOG4107RGJ metallophosphoesterase CSE15_10700 ENOG4105I7S Abortive infection protein CSE15_10705 ENOG4105C9U ATP-dependent DNA helicase RecQ CSE15_10710 ENOG4105T7X CSE15_10720 ENOG4108SAX Membrane CSE15_10725 ENOG4108JQ1 Dehydrogenase CSE15_10745 ENOG4105BZU Histidine kinase CSE15_10750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSE15_10755 ENOG4105CRE cytochrome C CSE15_10760 ENOG4107TWT Cytochrome c biogenesis protein CSE15_10770 ENOG4105FE9 pseudouridine synthase CSE15_10780 ENOG4108JIC nucleoside recognition domain protein CSE15_10785 ENOG4105DZ1 carboxypeptidase CSE15_10795 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CSE15_10800 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CSE15_10820 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CSE15_10825 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CSE15_10830 ENOG4108R6K riboflavin synthase, subunit alpha CSE15_10860 ENOG4107ZE5 PPIases accelerate the folding of proteins CSE15_10865 ENOG4105PTM secreted protein CSE15_10870 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CSE15_10880 ENOG4105G6R Stage v sporulation protein ae CSE15_10890 ENOG4105CZ3 stage V sporulation protein ad CSE15_10895 ENOG41090VF Stage v sporulation protein ac CSE15_10910 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSE15_10915 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CSE15_10920 ENOG41082AN stage II sporulation protein CSE15_10925 ENOG4105DZ1 carboxypeptidase CSE15_10930 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) CSE15_10935 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CSE15_10940 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CSE15_10950 ENOG4105I3K Ferric uptake regulator, Fur family CSE15_10955 ENOG4105MZ9 stage II sporulation protein m CSE15_10970 ENOG4107YB6 acetyltransferase, (GNAT) family CSE15_10980 ENOG4108YZ4 nudix hydrolase CSE15_10985 ENOG4105CPC Aldo Keto reductase CSE15_11010 ENOG4106HZJ CSE15_11015 ENOG4108YQE rare lipoprotein a CSE15_11020 ENOG4105RHY Pfam:UPF0157 CSE15_11025 ENOG4108XET gCN5-related N-acetyltransferase CSE15_11035 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CSE15_11045 ENOG4105E5W Transporter CSE15_11055 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase CSE15_11065 ENOG4108IXY short-chain dehydrogenase reductase CSE15_11070 ENOG41069FQ Metallo-beta-lactamase superfamily CSE15_11075 ENOG4105II7 pyrroline-5-carboxylate reductase CSE15_11090 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CSE15_11100 ENOG4105XT2 Transcriptional regulator CSE15_11105 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CSE15_11110 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CSE15_11115 ENOG4108TZY GntR Family Transcriptional Regulator CSE15_11120 ENOG4105CS2 ec 3.2.1.21 CSE15_11125 ENOG4105CK1 PTS System CSE15_11130 ENOG4105VCP PTS System CSE15_11135 ENOG4105VZJ PTS System CSE15_11145 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CSE15_11150 ENOG4105CSC Glucose uptake protein CSE15_11155 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CSE15_11160 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CSE15_11170 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) CSE15_11175 ENOG4108V3W Chemotaxis protein, CheW CSE15_11180 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CSE15_11185 ENOG4108HNZ carboxyl transferase CSE15_11190 ENOG4108ZVT methylmalonyl-coA epimerase CSE15_11195 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CSE15_11200 ENOG4108QEG Membrane CSE15_11205 ENOG4105CDA abc transporter atp-binding protein CSE15_11210 ENOG4105E5Q amino acid AbC transporter CSE15_11215 ENOG4108HW3 (ABC) transporter CSE15_11220 ENOG4108Y6J UPF0403 protein CSE15_11225 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CSE15_11235 ENOG4105C7S Dehydrogenase CSE15_11240 ENOG4105CPP Dehydrogenase, E1 component CSE15_11255 ENOG4105CKM Branched-chain carboxylic acid kinase CSE15_11260 ENOG4107RDP Dehydrogenase CSE15_11270 ENOG4108JUB Transcriptional regulator CSE15_11280 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CSE15_11290 ENOG4107QQR Sporulation CSE15_11295 ENOG4105S1Z Stage IV sporulation protein B CSE15_11300 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CSE15_11305 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CSE15_11315 ENOG4105DX0 Hemolysin A CSE15_11320 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CSE15_11325 ENOG4105CTB Polyprenyl synthetase CSE15_11330 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CSE15_11335 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CSE15_11340 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CSE15_11345 ENOG4105M7K Involved in the transcription termination process (By similarity) CSE15_11350 ENOG4108ZSR alkaline shock protein CSE15_11355 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CSE15_11375 ENOG410644B Stage III sporulation protein af CSE15_11385 ENOG4105KQ4 Stage iii sporulation protein ad CSE15_11390 ENOG4108CQH stage III sporulation protein AC CSE15_11395 ENOG4105KR5 Stage iii sporulation protein CSE15_11400 ENOG4105CD2 stage iii sporulation protein aa CSE15_11410 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CSE15_11415 ENOG4105DC7 peptidase M24 CSE15_11420 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CSE15_11430 ENOG4105CBJ Metal-dependent enzyme CSE15_11450 ENOG4105KST dependent repressor CSE15_11455 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CSE15_11460 ENOG4105WZW rhodanese family CSE15_11475 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CSE15_11480 ENOG4105C0D helicase CSE15_11505 ENOG4105VFR signal peptidase CSE15_11545 ENOG4106855 Competence protein CSE15_11580 ENOG4105C5X domain protein CSE15_11610 ENOG4105E0M Sulfatase CSE15_11625 ENOG4107ZXI Rhomboid family CSE15_11640 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CSE15_11645 ENOG4105WDJ 50S ribosomal protein L33 CSE15_11660 ENOG41068DG YceG-like family CSE15_11670 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CSE15_11675 ENOG4105E2Z phosphate ABC transporter (Permease CSE15_11680 ENOG4105C8U phosphate abc transporter CSE15_11685 ENOG4105CVA phosphate CSE15_11690 ENOG4107RF6 penicillin-binding protein CSE15_11700 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CSE15_11705 ENOG4105SXS Protein of unknown function (DUF456) CSE15_11715 ENOG4105D9U N-acetyltransferase CSE15_11725 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CSE15_11730 ENOG41063Y9 CSE15_11735 ENOG4108U5J '-nucleotidase CSE15_11745 ENOG41066F8 ROK family CSE15_11750 ENOG4105N80 Ferric uptake regulator, Fur family CSE15_11755 ENOG4105FAV ABC, transporter CSE15_11760 ENOG4105FDK ABC transporter CSE15_11765 ENOG4108JYZ YitT family CSE15_11770 ENOG41069ZM Protein of unknown function (DUF2624) CSE15_11775 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CSE15_11790 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CSE15_11795 ENOG4105EGD dinuclear metal center protein, YbgI family CSE15_11810 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSE15_11815 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CSE15_11820 ENOG4108UPT UPF0178 protein CSE15_11825 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) CSE15_11835 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CSE15_11840 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit CSE15_11845 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) CSE15_11855 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CSE15_11860 ENOG4105KG3 cytidine deaminase CSE15_11865 ENOG4107YR5 Diacylglycerol kinase CSE15_11870 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CSE15_11875 ENOG4105CTJ Metal Dependent Phosphohydrolase CSE15_11880 ENOG4105C9A Phoh family CSE15_11885 ENOG4105EI1 sporulation protein yqfd CSE15_11890 ENOG41068P3 sporulation protein YqfC CSE15_11900 ENOG4105DI5 UPF0365 protein CSE15_11905 ENOG4105F7J membrane-bound serine protease CSE15_11910 ENOG4105KTH gatB Yqey CSE15_11925 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CSE15_11930 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CSE15_11935 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CSE15_11940 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CSE15_11950 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CSE15_11955 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CSE15_11960 ENOG4105CSA Coproporphyrinogen iii oxidase CSE15_11965 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CSE15_11975 ENOG4108ZRV stage ii sporulation protein p CSE15_11990 ENOG4105TQK DNA polymerase iii, delta' subunit CSE15_12000 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CSE15_12005 ENOG4108UK2 deaminase CSE15_12020 ENOG4108D32 Methyltransferase CSE15_12030 ENOG4108WF2 Metal Dependent Phosphohydrolase CSE15_12035 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CSE15_12040 ENOG410812S Rna-binding protein CSE15_12045 ENOG4105E2X shikimate dehydrogenase CSE15_12050 ENOG4105CQW ribosome biogenesis GTPase YqeH CSE15_12055 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CSE15_12080 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSE15_12095 ENOG4107YCY Transcriptional regulator CSE15_12110 ENOG4108IUS Transketolase CSE15_12115 ENOG4108HHA Transketolase CSE15_12140 ENOG4108ZJ4 polysaccharide deacetylase CSE15_12175 ENOG4105CJ1 ABC, transporter CSE15_12200 ENOG4107QNK )-transporter CSE15_12205 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) CSE15_12220 ENOG4105CMD Transcriptional regulator, GntR family CSE15_12230 ENOG4105NTK Transcriptional repressor Mpra CSE15_12240 ENOG41080HJ 6-phospho 3-hexuloisomerase CSE15_12245 ENOG4108VA3 3-hexulose-6-phosphate synthase CSE15_12250 ENOG4105KVH Transcriptional regulator CSE15_12285 ENOG4108HWY Beta-lactamase CSE15_12310 ENOG4105E5Q amino acid AbC transporter CSE15_12315 ENOG4105WEF catalase CSE15_12330 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CSE15_12345 ENOG4107V2S Transcriptional regulator CSE15_12350 ENOG4108KYE ABC-2 type transporter CSE15_12355 ENOG41090VJ ABC-2 type transporter CSE15_12360 ENOG4105CJ1 ABC, transporter CSE15_12365 ENOG4105E2A Dehydrogenase CSE15_12390 ENOG4105C28 cystathionine CSE15_12400 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) CSE15_12405 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) CSE15_12420 ENOG4107XRG penicillin-binding protein CSE15_12425 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CSE15_12430 ENOG4107S03 uridine kinase CSE15_12435 ENOG4105CFP Peptidase U32 CSE15_12440 ENOG4105XYU peptidase (U32 family) CSE15_12445 ENOG4108VQJ O-methyltransferase CSE15_12450 ENOG4105HHA aminodeoxychorismate lyase CSE15_12460 ENOG4107F3J Amp-dependent synthetase and ligase CSE15_12465 ENOG4107ZYJ bioY protein CSE15_12475 ENOG4105VPH UPF0473 protein CSE15_12480 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CSE15_12485 ENOG4105VBH UPF0297 protein CSE15_12495 ENOG4105C02 permease CSE15_12500 ENOG4105CDA abc transporter atp-binding protein CSE15_12505 ENOG4105CT1 (ABC) transporter CSE15_12510 ENOG4105EAD ABC transporter CSE15_12515 ENOG4105DRP amino acid AbC transporter CSE15_12525 ENOG41060CR CSE15_12535 ENOG4105C7H Helicase, RecD TraA family CSE15_12545 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CSE15_12550 ENOG4105C3J Cysteine desulfurase CSE15_12560 ENOG4105D1H recombination factor protein RarA CSE15_12565 ENOG4105CUZ uba thif-type nad fad binding protein CSE15_12575 ENOG4105C9M aspartyl-trna synthetase CSE15_12580 ENOG4105CUT histidyl-tRNA synthetase CSE15_12585 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CSE15_12590 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CSE15_12595 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CSE15_12600 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CSE15_12605 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CSE15_12610 ENOG41067VP Protein of unknown function (DUF1049) CSE15_12615 ENOG4105NCW Trka-c domain protein CSE15_12620 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CSE15_12630 ENOG4105CKP Polysaccharide Biosynthesis Protein CSE15_12635 ENOG4108QG2 Membrane CSE15_12640 ENOG4105NAP CSE15_12645 ENOG4105VIE preprotein translocase, subunit YajC CSE15_12650 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CSE15_12655 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CSE15_12660 ENOG41061AI Protein of unknown function (DUF2905) CSE15_12665 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CSE15_12670 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CSE15_12705 ENOG4106678 morphogenetic protein associated with SpoVID CSE15_12710 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CSE15_12715 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CSE15_12720 ENOG4108IYU L-aspartate oxidase CSE15_12735 ENOG4105CQC Prephenate dehydratase CSE15_12745 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CSE15_12755 ENOG4105K46 50S ribosomal protein l27 CSE15_12760 ENOG4105X36 (ribosomal) protein CSE15_12765 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CSE15_12780 ENOG4107QMS site-determining protein CSE15_12790 ENOG4105YHC Rod shape-determining protein MreD CSE15_12795 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CSE15_12800 ENOG4105DFF Rod shape-determining protein mreb CSE15_12805 ENOG4105W5Q DNA repair protein (RadC CSE15_12810 ENOG4108Z03 MAF-like protein CSE15_12825 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CSE15_12830 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CSE15_12840 ENOG4106AR7 Spore coat protein CSE15_12845 ENOG41068KH stage VI sporulation protein D CSE15_12855 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CSE15_12860 ENOG4105D52 delta-aminolevulinic acid dehydratase CSE15_12870 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CSE15_12880 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CSE15_12890 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CSE15_12895 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CSE15_12900 ENOG4108IUQ atp-dependent protease CSE15_12905 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CSE15_12910 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CSE15_12920 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CSE15_12925 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CSE15_12930 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CSE15_12935 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CSE15_12940 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CSE15_12945 ENOG4108ZP8 Acetolactate synthase small subunit CSE15_12950 ENOG4105C7K acetolactate synthase CSE15_12955 ENOG4105CM2 brancheD-chain amino acid aminotransferase CSE15_12960 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CSE15_12975 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CSE15_12985 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CSE15_12990 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) CSE15_13030 ENOG4105M59 Phosphodiesterase, mj0936 family CSE15_13035 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CSE15_13040 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CSE15_13045 ENOG4108XJQ germination protein CSE15_13050 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CSE15_13055 ENOG41067TZ transcriptional regulator, MarR family CSE15_13060 ENOG4105PFC Transcriptional regulator CSE15_13070 ENOG4108KAM Transcriptional regulator CSE15_13075 ENOG4105C7F AcnD-accessory protein PrpF CSE15_13080 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CSE15_13090 ENOG4105E33 succinate dehydrogenase CSE15_13100 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CSE15_13110 ENOG4105CFH Aspartokinase CSE15_13115 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CSE15_13120 ENOG4105K63 Thioredoxin CSE15_13125 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) CSE15_13130 ENOG4105C10 Electron transfer flavoprotein CSE15_13135 ENOG4105BZJ Electron transfer flavoprotein CSE15_13140 ENOG41060WC Enoyl-CoA hydratase CSE15_13145 ENOG4107Z3H Transcriptional regulator, TetR family CSE15_13150 ENOG4105CEY Amp-dependent synthetase and ligase CSE15_13165 ENOG4105C98 muts2 protein CSE15_13170 ENOG4105DCG PHP domain protein CSE15_13180 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) CSE15_13185 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CSE15_13190 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CSE15_13195 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CSE15_13200 ENOG4108RWN rrna methyltransferase CSE15_13205 ENOG41067MF small acid-soluble spore protein CSE15_13215 ENOG4105CN9 Peptidase m42 family protein CSE15_13225 ENOG410696E Membrane CSE15_13230 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CSE15_13235 ENOG4105VJV 50s ribosomal protein L35 CSE15_13240 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CSE15_13250 ENOG4105U0R haloacid dehalogenase-like hydrolase CSE15_13255 ENOG4107SDU Methyl-accepting chemotaxis CSE15_13260 ENOG4105C22 threonyL-tRNA synthetase CSE15_13265 ENOG4108TDW sporulation protein YtxC CSE15_13285 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CSE15_13295 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CSE15_13300 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CSE15_13305 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CSE15_13315 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CSE15_13320 ENOG4105C2M dna polymerase I CSE15_13325 ENOG4105BZU Histidine kinase CSE15_13330 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CSE15_13340 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CSE15_13345 ENOG4108HMX isocitrate dehydrogenase (NADP) CSE15_13350 ENOG4105BZN citrate synthase CSE15_13355 ENOG4107CWS Protein of unknown function (DUF441) CSE15_13360 ENOG4108REF Sporulation integral membrane protein ytvi CSE15_13365 ENOG4105FS0 cytoplasmic membrane protein CSE15_13370 ENOG4105CA9 Pyruvate kinase CSE15_13375 ENOG4105CTQ phosphohexokinase CSE15_13385 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CSE15_13390 ENOG4105C6K Malic enzyme CSE15_13395 ENOG4105C0B DNA polymerase III (alpha subunit) CSE15_13400 ENOG4105VV2 CSE15_13410 ENOG4106EVM CSE15_13415 ENOG4105SFS phosphoesterase RecJ domain protein CSE15_13430 ENOG4105E8R UPF0173 metal-dependent hydrolase CSE15_13445 ENOG4105CH7 arginosuccinase CSE15_13450 ENOG4105CDH Citrulline--aspartate ligase CSE15_13455 ENOG4105EPU Molybdenum cofactor synthesis domain protein CSE15_13460 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CSE15_13470 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CSE15_13485 ENOG4105VK3 rdd domain containing protein CSE15_13490 ENOG4105D07 Signal peptide peptidase, SppA CSE15_13495 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CSE15_13500 ENOG4105C1J atp-dependent rna helicase CSE15_13505 ENOG4105ECK Fatty Acid Desaturase CSE15_13510 ENOG4108ZGX Histidine kinase CSE15_13515 ENOG4108S01 response regulator CSE15_13525 ENOG4105CJZ response regulator CSE15_13530 ENOG4105EWM Histidine kinase CSE15_13535 ENOG4105CNI cell division protein FtsW CSE15_13545 ENOG4105C19 ABC transporter CSE15_13555 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) CSE15_13560 ENOG4108X0B nad(p)h dehydrogenase (quinone) CSE15_13580 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CSE15_13585 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CSE15_13595 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) CSE15_13625 ENOG4105U5Y Transcriptional regulator CSE15_13635 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CSE15_13655 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold CSE15_13660 ENOG4105KAC Antibiotic biosynthesis monooxygenase CSE15_13665 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CSE15_13675 ENOG4105F1V Acetoin utilization protein CSE15_13680 ENOG4105W87 Cbs domain CSE15_13685 ENOG4105DGU Histone deacetylase CSE15_13690 ENOG4105ETE Transcriptional regulator (LacI family CSE15_13695 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CSE15_13715 ENOG4105DFU Cell wall formation (By similarity) CSE15_13725 ENOG4108VDD TRNA binding domain protein CSE15_13730 ENOG4108NKM UPF0354 protein CSE15_13745 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ CSE15_13760 ENOG4105C6K Malic enzyme CSE15_13765 ENOG4105C8F Beta-lactamase domain protein CSE15_13770 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CSE15_13780 ENOG4108V15 phosphotransferase enzyme family CSE15_13795 ENOG4107F58 2'-5' rna ligase CSE15_13800 ENOG4105C6T cysteine synthase CSE15_13805 ENOG4107UIE peptidase CSE15_13815 ENOG4105C7N Xanthine uracil vitamin C permease CSE15_13820 ENOG4105YW5 deoR family transcriptional regulator CSE15_13835 ENOG4105CBX hi0933 family CSE15_13845 ENOG4105C94 Transporter CSE15_13850 ENOG4106611 bacteriocin immunity CSE15_13860 ENOG41085GJ domain protein CSE15_13865 ENOG4105MU9 integral membrane protein CSE15_13870 ENOG4105DDC Oxidoreductase domain protein CSE15_13880 ENOG4105F5H Glycosyl Hydrolase Family 88 CSE15_13890 ENOG41075H3 AraC family transcriptional regulator CSE15_13895 ENOG4105KVH Transcriptional regulator CSE15_13900 ENOG4105F27 Major Facilitator CSE15_13905 ENOG4105CV8 reductase CSE15_13915 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CSE15_13925 ENOG4105NTD Inherit from COG: Hydrolase CSE15_13930 ENOG4105C8T Leucyl-tRNA synthetase CSE15_13940 ENOG4105BZU Histidine kinase CSE15_13945 ENOG4106UBQ CSE15_13950 ENOG4107R34 abc transporter permease protein CSE15_13955 ENOG4105C19 ABC transporter CSE15_13965 ENOG4105DVE abc transporter atp-binding protein CSE15_13970 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CSE15_13995 ENOG4108N23 SpoOM-related protein CSE15_14005 ENOG4105E8V Alpha Beta Hydrolase Fold protein CSE15_14010 ENOG4108Z0R Transferase CSE15_14015 ENOG4105CAQ asparagine synthetase CSE15_14020 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CSE15_14040 ENOG4105EWK phytoene CSE15_14060 ENOG4105D2X ABC transporter substrate-binding protein CSE15_14070 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CSE15_14080 ENOG4106FN3 tellurium resistance protein CSE15_14105 ENOG4108RMU ferritin dps family protein CSE15_14120 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) CSE15_14125 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CSE15_14130 ENOG4108V2W Carbonate dehydratase CSE15_14135 ENOG4105DSE periplasmic solute binding protein CSE15_14140 ENOG4105NRA 50s ribosomal protein l31 type b CSE15_14170 ENOG4105DTQ mandelate racemase muconate lactonizing CSE15_14180 ENOG4108IPT Naphthoate synthase CSE15_14185 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CSE15_14190 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CSE15_14195 ENOG4105E4F Isochorismate synthase CSE15_14200 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CSE15_14210 ENOG4108606 TspO/MBR family CSE15_14335 ENOG4105N67 Proton-coupled thiamine transporter YuaJ CSE15_14345 ENOG4105VRR gCN5-related N-acetyltransferase CSE15_14355 ENOG4105CNI cell division protein FtsW CSE15_14360 ENOG4105CNI cell division protein FtsW CSE15_14365 ENOG4105DZ6 Band 7 protein CSE15_14375 ENOG4106DF1 CSE15_14380 ENOG4108JB8 alcohol dehydrogenase CSE15_14385 ENOG4105C26 Dehydrogenase CSE15_14390 ENOG4105TRT Transcriptional regulator CSE15_14430 ENOG41068G1 CSE15_14445 ENOG410906S phage-like element pbsx protein xkdt CSE15_14450 ENOG41066EA baseplate J family protein CSE15_14455 ENOG4105MFU Protein of unknown function (DUF2634) CSE15_14465 ENOG4105X7F CSE15_14470 ENOG4108WZM domain protein CSE15_14475 ENOG4108FKH Transglycosylase SLT domain CSE15_14485 ENOG4105MTC XkdN-like protein CSE15_14495 ENOG4105FR7 XkdM protein, phage-like element PBSX CSE15_14500 ENOG4105PQS phage protein CSE15_14515 ENOG41060SN CSE15_14545 ENOG4105IG6 Phage terminase, large subunit CSE15_14565 ENOG4105QBX endodeoxyribonuclease RusA CSE15_14590 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CSE15_14600 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CSE15_14615 ENOG4105EE0 oxidoreductase CSE15_14620 ENOG4108Z0Z intracellular protease Pfpi family CSE15_14625 ENOG4105C8Q Methyl-accepting chemotaxis CSE15_14630 ENOG4105C8Q Methyl-accepting chemotaxis CSE15_14635 ENOG4105C8Q Methyl-accepting chemotaxis CSE15_14640 ENOG4105C8Q Methyl-accepting chemotaxis CSE15_14660 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme CSE15_14665 ENOG4105C37 (CBS) domain CSE15_14680 ENOG4107PBV potassium channel CSE15_14695 ENOG4107QYV phosphohexose isomerase CSE15_14705 ENOG4107QW4 alcohol dehydrogenase CSE15_14710 ENOG4105WG9 Conserved Protein CSE15_14720 ENOG4105CHM Aminotransferase CSE15_14725 ENOG4108ZB6 transcriptional regulator AsnC family CSE15_14740 ENOG4105C87 Aminotransferase class I and II CSE15_14745 ENOG4108HGU Histidine kinase CSE15_14750 ENOG4105Y38 Kinase-associated protein B CSE15_14765 ENOG4105BZ4 penicillin-binding protein CSE15_14770 ENOG4105KIR Thiol-disulfide oxidoreductase dcc CSE15_14785 ENOG4108MRH transcriptional regulatory protein CSE15_14790 ENOG4105DIH basic membrane CSE15_14795 ENOG4108JQ9 ABC transporter CSE15_14800 ENOG4105UIB (ABC) transporter CSE15_14820 ENOG4105D65 subunit l CSE15_14825 ENOG4105HC0 Na H antiporter CSE15_14830 ENOG4108ZE9 Monovalent cation H antiporter subunit C CSE15_14835 ENOG4108JPZ Monovalent cation H antiporter subunit D CSE15_14840 ENOG4105SC1 monovalent cation H antiporter subunit E CSE15_14850 ENOG4105KJM monovalent cation h antiporter subunit g CSE15_14855 ENOG4105KA0 thioesterase Superfamily protein CSE15_14865 ENOG4105BZU Histidine kinase CSE15_14890 ENOG4105D58 Diguanylate phosphodiesterase CSE15_14895 ENOG4105DAP Nicotinate phosphoribosyltransferase CSE15_14925 ENOG4105C02 permease CSE15_14945 ENOG410904N short-chain dehydrogenase reductase CSE15_14980 ENOG4108K8K Transcriptional regulator CSE15_14985 ENOG4105DCF alanine dehydrogenase CSE15_15000 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CSE15_15010 ENOG41069ER domain protein CSE15_15020 ENOG4105CEP NADH dehydrogenase CSE15_15025 ENOG4105CAY ferredoxin--nadp reductase CSE15_15050 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CSE15_15055 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CSE15_15060 ENOG4105ZKE UPF0349 protein CSE15_15080 ENOG41083MR nifu domain-containing protein CSE15_15085 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein CSE15_15095 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) CSE15_15100 ENOG4105D6E homoserine dehydrogenase CSE15_15105 ENOG4105C5I Dehydrogenase CSE15_15115 ENOG4108W5N phosphatidylglycerophosphatase a CSE15_15120 ENOG4105D4U had-superfamily hydrolase, subfamily iia CSE15_15130 ENOG4105MMD transcriptional regulator CSE15_15135 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CSE15_15145 ENOG4105FAA peptidase M23 CSE15_15160 ENOG4108YTE sporulation protein YunB CSE15_15165 ENOG4105KZD Domain of unknown function (DUF1805) CSE15_15170 ENOG4107R8B 5'-nucleotidase CSE15_15175 ENOG4105I3N Conserved Protein CSE15_15180 ENOG4105G9B Transcriptional regulator CSE15_15185 ENOG4105F0F Oxalate decarboxylase CSE15_15195 ENOG4105C5R Aminotransferase CSE15_15200 ENOG4108K8S endonuclease I CSE15_15210 ENOG4108IHU transport system permease protein CSE15_15215 ENOG4105DQ5 transport system permease protein CSE15_15220 ENOG4108MES Periplasmic binding protein CSE15_15245 ENOG4108SWU Histidine kinase CSE15_15250 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CSE15_15255 ENOG4105DHF Membrane CSE15_15265 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CSE15_15275 ENOG4108IG5 Transcriptional regulator CSE15_15280 ENOG4105DIW FeS assembly protein SUFB CSE15_15285 ENOG4108UNV SUF system FeS assembly protein, NifU family CSE15_15290 ENOG4105C9B Cysteine desulfurase CSE15_15295 ENOG4105JRK feS assembly protein SufD CSE15_15300 ENOG4105C3K feS assembly ATPase SufC CSE15_15310 ENOG4105D01 (LipO)protein CSE15_15315 ENOG4108UMI ABC transporter, permease CSE15_15320 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CSE15_15345 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CSE15_15350 ENOG41080E8 Transcriptional regulator, Spx MgsR family CSE15_15355 ENOG4105C1G acyl-Coa dehydrogenase CSE15_15360 ENOG4105CHU acetyl-coa acetyltransferase CSE15_15390 ENOG4105E0A ABC, transporter CSE15_15400 ENOG4105E1F short-chain dehydrogenase reductase CSE15_15405 ENOG4105C0H protease CSE15_15415 ENOG4105F3H Histidine kinase CSE15_15425 ENOG41067SE Tetr family transcriptional regulator CSE15_15430 ENOG4105C9Q fumarate hydratase class II CSE15_15460 ENOG4105WH1 Two component transcriptional regulator luxr family CSE15_15465 ENOG4105ENE Histidine kinase CSE15_15480 ENOG41087YS Phage shock protein A CSE15_15490 ENOG4108WBT adenosyltransferase CSE15_15495 ENOG4105CHR reductase CSE15_15500 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) CSE15_15505 ENOG4107S2N Type III effector Hrp-dependent CSE15_15530 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CSE15_15535 ENOG4105E0A ABC, transporter CSE15_15540 ENOG4105EHG Permease protein CSE15_15545 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CSE15_15560 ENOG4107QZW Altronate oxidoreductase CSE15_15565 ENOG4107KJX Transcriptional regulator CSE15_15570 ENOG4105D2H Uronic isomerase CSE15_15580 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CSE15_15585 ENOG4105E0A ABC, transporter CSE15_15590 ENOG4105EHG Permease protein CSE15_15595 ENOG4105DQ5 transport system permease protein CSE15_15605 ENOG4105D5Q Arginine ornithine antiporter CSE15_15625 ENOG4107K5X Membrane-bound metal-dependent hydrolase CSE15_15630 ENOG4107QZ2 Sulfatase CSE15_15635 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CSE15_15640 ENOG4105E0C molybdate abc transporter CSE15_15650 ENOG4105EVU fructokinase CSE15_15655 ENOG4107SUZ Sodium/hydrogen exchanger family CSE15_15660 ENOG4105EN6 Membrane CSE15_15670 ENOG4107ZQN disulfide bond CSE15_15675 ENOG4105C59 p-type ATPase CSE15_15680 ENOG4105DIK (ABC) transporter CSE15_15685 ENOG4105CC5 ABC transporter CSE15_15690 ENOG4105DSE periplasmic solute binding protein CSE15_15695 ENOG4105IIP Membrane CSE15_15700 ENOG4105W1N transcriptional regulator CSE15_15720 ENOG4108IJ0 Aspartate ammonia-lyase CSE15_15735 ENOG4105C59 p-type ATPase CSE15_15740 ENOG410681U heavy metal transport detoxification protein CSE15_15745 ENOG4105VPX protein, conserved in bacteria CSE15_15755 ENOG4105BZU Histidine kinase CSE15_15765 ENOG4107SJB teichoic acid biosynthesis CSE15_15775 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CSE15_15780 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CSE15_15790 ENOG4105XZU Preprotein translocase, subunit SecG CSE15_15815 ENOG4105KVH Transcriptional regulator CSE15_15820 ENOG4105R40 Glycine betaine carnitine choline CSE15_15825 ENOG4108HQR Glycine betaine CSE15_15830 ENOG4105E90 ABC transporter CSE15_15835 ENOG4108IJ8 ABC transporter CSE15_15840 ENOG4107HG4 Transcriptional regulator CSE15_15845 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein CSE15_15855 ENOG4108W0I acetyltransferase CSE15_15885 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CSE15_15895 ENOG4105CP7 Triose-phosphate isomerase CSE15_15900 ENOG4105BZA Phosphoglycerate kinase CSE15_15905 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CSE15_15920 ENOG4105C8Y Acetylornithine aminotransferase CSE15_15925 ENOG4108JUB Transcriptional regulator CSE15_15930 ENOG4105JXH GntR family transcriptional regulator CSE15_15935 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CSE15_15945 ENOG4107R73 Mate efflux family protein CSE15_15950 ENOG4108JQ7 (ABC) transporter CSE15_15960 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CSE15_15965 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSE15_15970 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CSE15_15975 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CSE15_15980 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family CSE15_15985 ENOG4105D3Q Sugar transferase CSE15_16000 ENOG4107QRS glycosyltransferase group 2 family protein CSE15_16005 ENOG41068W6 Capsular polysaccharide biosynthesis protein CSE15_16010 ENOG4108KMV Glycosyl transferase (Group 1 CSE15_16015 ENOG4105K64 Glycosyl transferase, family 2 CSE15_16020 ENOG4108PQP glycosyl transferase group 1 CSE15_16030 ENOG4108QV3 biosynthesis protein CSE15_16035 ENOG4105HTX biosynthesis protein CSE15_16050 ENOG4108V5C ABC transporter CSE15_16055 ENOG4105EHG Permease protein CSE15_16060 ENOG4105DQ5 transport system permease protein CSE15_16065 ENOG4108ZJ4 polysaccharide deacetylase CSE15_16090 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CSE15_16095 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CSE15_16145 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CSE15_16185 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CSE15_16355 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) CSE15_16370 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CSE15_16380 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CSE15_16390 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CSE15_16395 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CSE15_16415 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) CSE15_16565 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CSE15_16570 ENOG4108URH decarboxylase CSE15_16575 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain CSE15_16585 ENOG4105CHH sulfate transporter CSE15_16590 ENOG4108V2W Carbonate dehydratase CSE15_16595 ENOG4105C5I Dehydrogenase CSE15_16605 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CSE15_16610 ENOG4105KRI phosphocarrier protein (HPr CSE15_16615 ENOG4105CIE May be required for sporulation (By similarity) CSE15_16620 ENOG4105CHW UPF0052 protein CSE15_16625 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CSE15_16630 ENOG4108Z4K mutator MutT protein CSE15_16635 ENOG4105C3M thioredoxin reductase CSE15_16650 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CSE15_16655 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CSE15_16660 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CSE15_16665 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CSE15_16670 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CSE15_16675 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CSE15_16680 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CSE15_16685 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) CSE15_16710 ENOG4108RYK Nad-dependent epimerase dehydratase CSE15_16715 ENOG4108Z40 Transcriptional regulator CSE15_16720 ENOG4108S4C acetyltransferase CSE15_16725 ENOG4107XGZ Hydrolase CSE15_16730 ENOG4105HKU nucleoside recognition domain-containing protein CSE15_16740 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) CSE15_16745 ENOG4105CE4 GlcNAc 6-P deacetylase CSE15_16750 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CSE15_16755 ENOG4105FDP GntR family transcriptional regulator CSE15_16760 ENOG41088CQ domain protein CSE15_16765 ENOG41086DT Membrane protein of unknown function CSE15_16770 ENOG41067S9 phage shock protein C, PspC CSE15_16775 ENOG4108PY7 CSE15_16790 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CSE15_16795 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CSE15_16815 ENOG4105MKU Transcriptional regulator CSE15_16830 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSE15_16835 ENOG4105BZU Histidine kinase CSE15_16840 ENOG4105EDW glycosyl transferase, family 39 CSE15_16845 ENOG4105CKK Glycosyl transferase, family 2 CSE15_16855 ENOG4108RCM Nitroreductase CSE15_16860 ENOG4105KVH Transcriptional regulator CSE15_16875 ENOG4105CN1 protease CSE15_16890 ENOG4105CRP Part of the ABC transporter FtsEX involved in CSE15_16895 ENOG4105CAK Cell division ATP-binding protein ftsE CSE15_16935 ENOG4105MS2 ribosomal subunit Interface protein CSE15_16940 ENOG4105C8Q Methyl-accepting chemotaxis CSE15_16955 ENOG4105MQ3 flagellar protein FliS CSE15_16960 ENOG4107RT6 flagellar hook-associated CSE15_16965 ENOG41083S7 flagellar protein FlaG CSE15_16970 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) CSE15_16975 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) CSE15_16980 ENOG4105MKD CSE15_16985 ENOG4105DTJ flagellar hook-associated protein CSE15_16990 ENOG4105E1Q flagellar hook-associated protein CSE15_17005 ENOG4105RU3 CSE15_17010 ENOG41081UC Inherit from COG: Competence protein CSE15_17030 ENOG4105WH1 Two component transcriptional regulator luxr family CSE15_17035 ENOG4105BZU Histidine kinase CSE15_17040 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CSE15_17045 ENOG4108KGH TRANSCRIPTIONal CSE15_17050 ENOG4105ESV Glycosyl transferase, family 4 CSE15_17055 ENOG4107EF8 Glycosyl transferase (Group 1 CSE15_17070 ENOG4105QZI O-Antigen Polymerase CSE15_17075 ENOG4105C1B dTDP-glucose 4-6-dehydratase CSE15_17080 ENOG4105C6Y Udp-glucose 6-dehydrogenase CSE15_17085 ENOG4107RA4 Glycosyl transferase (Group 1 CSE15_17090 ENOG4105PSV Polysaccharide Biosynthesis Protein CSE15_17095 ENOG4105D3Q Sugar transferase CSE15_17105 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CSE15_17110 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CSE15_17115 ENOG4105JFG SpoIID LytB domain protein CSE15_17125 ENOG4108KGH TRANSCRIPTIONal CSE15_17150 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CSE15_17155 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CSE15_17160 ENOG4105EY8 ABC transporter CSE15_17180 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase CSE15_17190 ENOG4107RZX Teichoic acid biosynthesis protein CSE15_17200 ENOG4105DG6 mannose-6-phosphate isomerase CSE15_17210 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CSE15_17215 ENOG4108JP0 extracellular solute-binding protein family 1 CSE15_17220 ENOG4105WH1 Two component transcriptional regulator luxr family CSE15_17235 ENOG4105I4A GCN5-related N-acetyltransferase CSE15_17240 ENOG4108UHU Aldolase CSE15_17245 ENOG4105D7K pfkb domain protein CSE15_17250 ENOG4108M60 Transcriptional regulator CSE15_17255 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) CSE15_17260 ENOG4105CHR reductase CSE15_17275 ENOG4108NHD germination protein CSE15_17285 ENOG4107RGC Glycosyl transferase, family 2 CSE15_17290 ENOG4105C54 Major Facilitator superfamily CSE15_17295 ENOG4108KGH TRANSCRIPTIONal CSE15_17300 ENOG4105J7I hydrolase CSE15_17305 ENOG4105K4H Nlp p60 protein CSE15_17315 ENOG4105PNM synthesis protein CSE15_17325 ENOG4105N98 Capsule biosynthesis protein capB CSE15_17345 ENOG4105ETE Transcriptional regulator (LacI family CSE15_17350 ENOG4108RVA ribokinase CSE15_17355 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) CSE15_17360 ENOG4105C2J ABC transporter CSE15_17365 ENOG4105CNN ABC, transporter CSE15_17370 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CSE15_17375 ENOG4107XC4 flavin reductase domain protein, FMN-binding CSE15_17380 ENOG4107RSM transcriptional regulator CSE15_17390 ENOG4107FQX Alpha-acetolactate decarboxylase CSE15_17400 ENOG4105CAH Chromate CSE15_17405 ENOG4105FGV Chromate CSE15_17410 ENOG4105C6Y Udp-glucose 6-dehydrogenase CSE15_17420 ENOG4105KBK Zinc finger, swim domain protein CSE15_17425 ENOG4105C0D helicase CSE15_17430 ENOG4105BZU Histidine kinase CSE15_17435 ENOG410667J hydrolase CSE15_17455 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CSE15_17465 ENOG4105CGA flagellar basal-body rod protein FlgG CSE15_17475 ENOG4105DFF Rod shape-determining protein mreb CSE15_17480 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CSE15_17485 ENOG4107MII Sugar-specific transcriptional regulator TrmB CSE15_17490 ENOG4105CZM Major Facilitator CSE15_17495 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CSE15_17500 ENOG41080V3 Major Facilitator superfamily CSE15_17505 ENOG4105EAB amino acid AbC transporter CSE15_17510 ENOG4105E5Q amino acid AbC transporter CSE15_17515 ENOG4105CDA abc transporter atp-binding protein CSE15_17525 ENOG4105BZU Histidine kinase CSE15_17535 ENOG4105FRN stage II sporulation protein CSE15_17540 ENOG4107TCE N-acetyltransferase CSE15_17580 ENOG4105WDJ 50S ribosomal protein L33 CSE15_17585 ENOG4105CKI cobalamin synthesis protein CSE15_17590 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CSE15_17600 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CSE15_17605 ENOG4105FCD Major Facilitator CSE15_17610 ENOG4108J2R molybdopterin oxidoreductase CSE15_17615 ENOG4108TF4 von Willebrand factor, type A CSE15_17630 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CSE15_17640 ENOG4106778 Protein of unknown function (DUF1146) CSE15_17650 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CSE15_17655 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CSE15_17660 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CSE15_17665 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CSE15_17685 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) CSE15_17695 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CSE15_17700 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CSE15_17705 ENOG4108UIC UPF0340 protein CSE15_17710 ENOG4108YZG isomerase CSE15_17715 ENOG4107WAU Protein tyrosine phosphatase CSE15_17725 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CSE15_17735 ENOG4108ZXQ stage ii sporulation protein r CSE15_17745 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CSE15_17750 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CSE15_17760 ENOG4107TT2 Auxin Efflux Carrier CSE15_17765 ENOG4105C6K Malic enzyme CSE15_17770 ENOG4107104 thymidine kinase CSE15_17775 ENOG41082DI 50s ribosomal protein l31 CSE15_17780 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CSE15_17785 ENOG4105CBT Fructose-1,6-bisphosphatase CSE15_17790 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CSE15_17800 ENOG4105D2N Aldolase CSE15_17805 ENOG410812K response regulator receiver protein CSE15_17815 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CSE15_17825 ENOG41081I9 integral membrane protein CSE15_17835 ENOG4105C1G acyl-Coa dehydrogenase CSE15_17840 ENOG4105C1G acyl-Coa dehydrogenase CSE15_17845 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CSE15_17855 ENOG4105DF6 Fe-S oxidoreductase CSE15_17885 ENOG4105BZ1 (ABC) transporter CSE15_17890 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CSE15_17905 ENOG4105C75 arginyL-tRNA synthetase CSE15_17910 ENOG410684U Domain of unknown function (DUF1934) CSE15_17920 ENOG4105CYW agmatinase CSE15_17925 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CSE15_17930 ENOG4105BZ4 penicillin-binding protein CSE15_17935 ENOG4108XFG YwhD family CSE15_17940 ENOG4108Z4T Peptidase M50 CSE15_17945 ENOG41069HH 4-oxalocrotonate tautomerase CSE15_17960 ENOG4108KSA LysR family transcriptional regulator CSE15_17965 ENOG4108UZX fmn reductase CSE15_17970 ENOG4105DEN Luciferase family CSE15_17980 ENOG4108XSB acetyltransferase, (GNAT) family CSE15_17995 ENOG4105E5Q amino acid AbC transporter CSE15_18000 ENOG4105CDA abc transporter atp-binding protein CSE15_18010 ENOG4105DCI Phosphohydrolase CSE15_18015 ENOG4105QAT UPF0741 protein CSE15_18020 ENOG4108VCI transcription factor, rsfa family CSE15_18030 ENOG4107QZ7 Cellulose synthase catalytic subunit CSE15_18040 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CSE15_18075 ENOG4107EV6 Inherit from COG: YD repeat protein CSE15_18105 ENOG4105JSC dimethylmenaquinone methyltransferase CSE15_18115 ENOG4108IJ2 phosphate acetyltransferase CSE15_18120 ENOG4107JTW chlorite dismutase CSE15_18125 ENOG4105F27 Major Facilitator CSE15_18135 ENOG4105FCW Major Facilitator superfamily CSE15_18140 ENOG41061WN bacilysin biosynthesis protein CSE15_18150 ENOG4105CHR reductase CSE15_18160 ENOG4105CHM Aminotransferase CSE15_18170 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase CSE15_18175 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CSE15_18180 ENOG4105C1B dTDP-glucose 4-6-dehydratase CSE15_18185 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CSE15_18190 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG CSE15_18195 ENOG4107TY6 Acylneuraminate cytidylyltransferase CSE15_18205 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD CSE15_18210 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CSE15_18255 ENOG4105C26 Dehydrogenase CSE15_18260 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CSE15_18265 ENOG4108RJ9 Glycosyl transferase, family 2 CSE15_18275 ENOG4105DWF phosphomethylpyrimidine kinase CSE15_18295 ENOG4105C5Y PTS System CSE15_18310 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CSE15_18320 ENOG4105DEN Luciferase family CSE15_18325 ENOG4108DBC nitroreductase CSE15_18340 ENOG41060D1 Quinol oxidase CSE15_18345 ENOG4105CCU oxidase (Subunit III) CSE15_18350 ENOG4105BZ9 Cytochrome C oxidase, subunit I CSE15_18355 ENOG4105E2S oxidase) subunit II CSE15_18370 ENOG4105CMR udp-glucose 4-epimerase CSE15_18375 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CSE15_18390 ENOG4105WH5 Teichoic acid glycosylation protein CSE15_18430 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CSE15_18435 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase CSE15_18440 ENOG4105CMU LysR family (Transcriptional regulator CSE15_18450 ENOG41067MG lrgb family CSE15_18455 ENOG4105DR4 Methyltransferase CSE15_18470 ENOG4105E5Q amino acid AbC transporter CSE15_18475 ENOG4107R0W ABC transporter CSE15_18490 ENOG4105CNN ABC, transporter CSE15_18495 ENOG4105C2J ABC transporter CSE15_18500 ENOG4108QGH periplasmic CSE15_18505 ENOG4108M26 parallel beta-helix repeat protein CSE15_18510 ENOG4105CM2 brancheD-chain amino acid aminotransferase CSE15_18525 ENOG4105F8D glycoside hydrolase family 4 CSE15_18530 ENOG4105VCP PTS System CSE15_18535 ENOG4105CK1 PTS System CSE15_18540 ENOG4105VZJ PTS System CSE15_18545 ENOG4105EMD TRANSCRIPTIONal CSE15_18560 ENOG4107R37 Glutamate dehydrogenase CSE15_18580 ENOG4108J20 pectate lyase CSE15_18585 ENOG4108JJ8 (ABC) transporter CSE15_18590 ENOG4108JJ9 ABC, transporter CSE15_18600 ENOG4105C4M (Ubiquinol oxidase) subunit I CSE15_18605 ENOG4105E0A ABC, transporter CSE15_18610 ENOG4105DQ5 transport system permease protein CSE15_18615 ENOG4108HUF Transporter CSE15_18620 ENOG4105KFN sortase, SrtB family CSE15_18645 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) CSE15_18650 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) CSE15_18655 ENOG4105KVH Transcriptional regulator CSE15_18660 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CSE15_18665 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CSE15_18670 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CSE15_18680 ENOG4107BJW polysaccharide deacetylase CSE15_18685 ENOG4105VCP PTS System CSE15_18690 ENOG4105VZJ PTS System CSE15_18695 ENOG4105CS2 ec 3.2.1.21 CSE15_18700 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CSE15_18705 ENOG4105CK1 PTS System CSE15_18710 ENOG4105EMD TRANSCRIPTIONal CSE15_18735 ENOG4105DFD Na H antiporter CSE15_18740 ENOG4108IJ0 Aspartate ammonia-lyase CSE15_18745 ENOG4105HDK L-asparaginase CSE15_18750 ENOG4108IMY Transcriptional regulator CSE15_18780 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CSE15_18795 ENOG4106KNT transcriptional regulator CSE15_18800 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CSE15_18810 ENOG4105C6Z Gluconate CSE15_18820 ENOG4105CS2 ec 3.2.1.21 CSE15_18825 ENOG4105C5Y PTS System CSE15_18830 ENOG4105CID antiterminator CSE15_18835 ENOG4108XI2 Domain of unknown function (DUF1963) CSE15_18845 ENOG4108W7F transporter, permease CSE15_18850 ENOG4108JJB ABC transporter CSE15_18855 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein CSE15_18860 ENOG4105ETU transcriptional activator (TenA CSE15_18885 ENOG4107G87 m6 family metalloprotease domain protein CSE15_18890 ENOG41067V3 Antibiotic biosynthesis monooxygenase CSE15_18895 ENOG4108TVJ Nitroreductase CSE15_18900 ENOG4105FS7 Transcriptional regulator CSE15_18905 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CSE15_18910 ENOG4105D9N nucleoside CSE15_18915 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CSE15_18920 ENOG4107RHR regulatoR CSE15_18930 ENOG4105EXC Acyl-transferase CSE15_18935 ENOG4105DXI Major Facilitator superfamily CSE15_18940 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CSE15_18945 ENOG4105HMZ Methyltransferase CSE15_18955 ENOG410667J hydrolase CSE15_18960 ENOG4105W1Y Transcriptional regulator CSE15_18965 ENOG4105EE0 oxidoreductase CSE15_18970 ENOG4105FKZ Methyl-accepting chemotaxis CSE15_18980 ENOG4105F1N DNA alkylation repair CSE15_18985 ENOG4105C6Z Gluconate CSE15_18990 ENOG4105CMG Carbohydrate kinase CSE15_18995 ENOG4106KNT transcriptional regulator CSE15_19035 ENOG4105DUM transcriptional regulator, lysR family CSE15_19045 ENOG4107FKK extracellular solute-binding protein family 1 CSE15_19055 ENOG4105EG2 ABC transporter, permease CSE15_19065 ENOG4105C4C beta-galactosidase CSE15_19070 ENOG4105D4T Citrate transporter CSE15_19080 ENOG4108TU7 Inherit from COG: (ABC) transporter CSE15_19085 ENOG4105CJ1 ABC, transporter CSE15_19095 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CSE15_19105 ENOG4105BZW Glycerate kinase CSE15_19110 ENOG4107QQ0 gntp family CSE15_19115 ENOG4107VHA regulatoR CSE15_19120 ENOG4105YA8 Transcriptional regulator CSE15_19125 ENOG4107Y80 Major Facilitator superfamily CSE15_19135 ENOG4105C19 ABC transporter CSE15_19145 ENOG410780I phosphoprotein phosphatase activity CSE15_19150 ENOG4105CID antiterminator CSE15_19155 ENOG4105CS2 ec 3.2.1.21 CSE15_19160 ENOG4105C5Y PTS System CSE15_19185 ENOG4105M6F mutator MutT protein CSE15_19200 ENOG4105C85 amino acid CSE15_19205 ENOG4105ETE Transcriptional regulator (LacI family CSE15_19220 ENOG4105E2X shikimate dehydrogenase CSE15_19265 ENOG4105CS2 ec 3.2.1.21 CSE15_19270 ENOG4105C5Y PTS System CSE15_19275 ENOG4108S3Y transcriptional regulator CSE15_19285 ENOG4105JAB phenazine biosynthesis protein, phzf family CSE15_19290 ENOG41080UQ Transcriptional regulator CSE15_19310 ENOG4105DS0 Transcriptional regulator, Crp Fnr family CSE15_19320 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CSE15_19345 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CSE15_19360 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CSE15_19370 ENOG4108V7D UPF0397 protein CSE15_19390 ENOG4105WQG acetyltransferase CSE15_19395 ENOG4105C0H protease CSE15_19400 ENOG4105Q2H domain protein CSE15_19415 ENOG4105BZU Histidine kinase CSE15_19420 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CSE15_19445 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CSE15_19460 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CSE15_19465 ENOG4105ST3 Transcriptional regulator CSE15_19470 ENOG4106A3M Cytochrome p-450 CSE15_19475 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase CSE15_19480 ENOG4105CDU Replicative dna helicase CSE15_19485 ENOG4106K80 CSE15_19490 ENOG4106K80 CSE15_19500 ENOG4105NIV Esterase CSE15_19505 ENOG410874W AraC family transcriptional regulator CSE15_19515 ENOG4108SA1 esterase CSE15_19525 ENOG4105DJ2 Major Facilitator Superfamily CSE15_19530 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CSE15_19535 ENOG4105BZR domain protein CSE15_19540 ENOG4108XMW Membrane CSE15_19545 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase CSE15_19550 ENOG4108P49 AntiSigma factor CSE15_19555 ENOG4105JVQ RNA Polymerase CSE15_19565 ENOG4105CH6 catalase CSE15_19570 ENOG4105CS1 NAD(P)H quinone oxidoreductase CSE15_19575 ENOG4105FBA Phospholipase Carboxylesterase CSE15_19580 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CSE15_19585 ENOG4105E90 ABC transporter CSE15_19590 ENOG4108IJ8 ABC transporter CSE15_19595 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CSE15_19600 ENOG4108UUM single-stranded DNA-binding protein CSE15_19605 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CSE15_19610 ENOG4105C3G gtp-binding protein CSE15_19615 ENOG4105VDK protein, conserved in bacteria CSE15_19635 ENOG4108ZDA Sporulation protein YyaC CSE15_19640 ENOG4105FA0 parb-like partition protein CSE15_19645 ENOG4107QJE Chromosome Partitioning Protein CSE15_19660 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CSE15_19665 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CSE15_19670 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CSE15_19680 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CSE15_19685 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)